Conserved Protein Domain Family
ADP_ribosyl_GH
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pfam03747: ADP_ribosyl_GH (this model, PSSM-Id:377122 is obsolete and has been replaced by 461037)
ADP-ribosylglycohydrolase
This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.
Links
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Statistics
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PSSM-Id: 377122
Aligned: 774 rows
Threshold Bit Score: 37.9874
Created: 19-Jun-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EFC47136             59 GALFGVTWGDVIGCPVEGWRQE--EIEELFGDENmlklfdfktiiekrndgslklqnitkdgidflfpsddlissklktl 136 Naegleri...
jgi:Mboo_0067         1 --MLGAAVGDALGMPNESTMPG--LTKMRYGFRK---------------------------------------------- 30  Methanor...
jgi:Memar_0150        7 GCLLGAAIGDALGMARESTPPDfqRLHEGYRRAW---------------------------------------------- 40  Methanoc...
EJG06009              7 GCMLGAAIGDALGMPGE-SAAM--NLSHMYQGYR---------------------------------------------- 37  Methanof...
jgi:HY04AAS1_0374     7 GIVLGSAIGDAIGKSFEDLDIY--QVEEFYKDLPit-------------------------------------------- 40  Hydrogen...
O66816               11 GAVLGAAVGDALGKSVEDITEE--EVFEFYGDRI---------------------------------------------- 42  Aquifex ...
BAI68954              8 GTLLGAALGDAIGKCVEDITKE--EVYDFYGSRVeg-------------------------------------------- 41  Hydrogen...
jgi:Thal_1377        11 GTLLGGAIGDALGKDVEDLTEE--EVRDLYGGRI---------------------------------------------- 42  Thermocr...
jcvi:cds.PERMA_1427   7 GALVGAAVGDSMGMCVEEIPFD--EVILHYGDKItn-------------------------------------------- 40  Persepho...
jgi:SYO3AOP1_1600     7 GTLLGAAIGDSLGMMVEELPVD--EVIEFYGEPVkd-------------------------------------------- 40  Sulfurih...

EFC47136            137 stesdekknkrkKSPFESFLSRCRFPGIH----SDDTQQGMALINSIVQYCEL-NPsGKYFGEiWGEWLVRgfetcscky 211 Naegleri...
jgi:Mboo_0067        31 --------------AYKGHPNDGLSPGQY----TDDTQIMILVATLLAD-GKY-ND-ERYGLAlKELYAR---------- 79  Methanor...
jgi:Memar_0150       41 ----------------RGHPNTGLKPGQF----TDDTQMMLLVAEMLAD-DTY-SE-SAYAAAlARMYMN---------- 87  Methanoc...
EJG06009             38 -------------RAWKWHPNAHLEPGQY----TDDTQIMLLVAGLIAS-GNY-SE-ERYAADlARLCME---------- 87  Methanof...
jgi:HY04AAS1_0374    41 ----------nfVEPHPSSPAFFQKPNEP----SDETNVSRLLIESILESNKL-DI-YNYFDKlKA-WAF---------- 93  Hydrogen...
O66816               43 -------------RDFVTPHPSSPAYGQLpeetSDETTIFRLLLESLVEKKAL-DV-RDFLNRlME-WYD---------- 96  Aquifex ...
BAI68954             42 -----------fVEPHPLSPSYGSHPEEI----SDETKITLILLESVVDKKAI-DP-QDFYKRlIL-WRE---------- 93  Hydrogen...
jgi:Thal_1377        43 ------------------ENYVGPNPGET----SDETTISLLLLESILSRKRI-DP-YDFFQRlYS-WRLQ--------- 88  Thermocr...
jcvi:cds.PERMA_1427  41 -----------iCEPHPASPASYLKAGET----SSEFEIVKIVAQSLSEKKIL-DI-KDIIERyIQ-WEE---------- 92  Persepho...
jgi:SYO3AOP1_1600    41 -----------lLIPHPSSPSYFLRPGEN----TSEFEIIKLIVEAIVE-RKFiDT-KYIIEKyIQ-WLE---------- 92  Sulfurih...

EFC47136            212 pmksgqveeigrGVQAFRDYGANSSKAFTNLKK--NIPAHEAGSS-SSGIGGIMRGAIAtAVFSLFshesDDEKAIQMIE 288 Naegleri...
jgi:Mboo_0067        80 --------------EVLRFPDGSISAACDHMIS--GQ-ATSCGVK-STTAGCLPASLPF-ALVYP-----DIHEATGRAV 135 Methanor...
jgi:Memar_0150       88 --------------EELRFPDGAVDAACRHLLLssGK----PGGVsSDTAGCTGIAVPF-GLLYG-----DPIDVTERVV 143 Methanoc...
EJG06009             88 --------------GDLRFPDGSVMSACEHLLTc-GI--EKSGVS-SDTSGCIPLAVPF-ALRYS-----DAVERSGRLV 143 Methanof...
jgi:HY04AAS1_0374    94 ------------DETTHRYPDPFILKAIYNLSN--NI---IEGLR-FSSVEGILRVIAT-SMLHFE----NEALSDEAAK 150 Hydrogen...
O66816               97 ------------REEMHRYPDPMLLTAIDLLSR--GINPSTHGLT-SFSVEGILRSVAL-GLYHYY----NPELAAEGSK 156 Aquifex ...
BAI68954             94 ------------DEKSHRYPDPALLTALDLLSS--GISLEEAGFS-SASVEGILRCIVV-GLFHFY----NPLLASEGAR 153 Hydrogen...
jgi:Thal_1377        89 -------------EEKHRYPDPALLTAIDLLSA--GVSLTEAGFY-SCSVEGILRCTVV-GLYHFN----SPYVAAEGGR 147 Thermocr...
jcvi:cds.PERMA_1427  93 ------------KEELHSYVDPYFLLAIDALKN--GREIERg----GSSIEGALPAIPL-GMYHYT----NPVLAVEGTK 149 Persepho...
jgi:SYO3AOP1_1600    93 ------------KDQVHTYIDPTFLLAIESIKE--GTEPPLTg---SAIDHSLVAI-PA-GMYYYK----DPYQASEVAK 149 Sulfurih...

EFC47136            289 KFSfeqnLTTHATIEGAATCFATSLCAYMFLKLGQERAIEWIldnladrvkkaedkwwnnsrittereeqekeekkpkkk 368 Naegleri...
jgi:Mboo_0067       136 RAC----SITHTHPAAHAAVSTFVTLVYSAIHGHADPVEKALaqaqnedevlggkihn---------------------- 189 Methanor...
jgi:Memar_0150      144 QAC----SVTHTHPGAHAGAVTVAMLVHHAVRGRSDALELAEkhagledvalgnkird---------------------- 197 Methanoc...
EJG06009            144 KAC----SVTHTNPVAHAGAVTVAALLASAVHGEREPFAAAVrcaaaedpelgrrigr---------------------- 197 Methanof...
jgi:HY04AAS1_0374   151 LVT----MLTHRSDEALDGAILFNRFLVKSIKNDESLETLENriellkelkscvksfytkk------------------- 207 Hydrogen...
O66816              157 VVS----LLTHRSDVISDASAILGALIAHLVRGDFYLEDFREklrlietlkdyakeekhkk------------------- 213 Aquifex ...
BAI68954            154 LVS----IMTHRSPEVYDASAVLAVMISNLIRDAYHLDNLDErvklleelklfvkhdrhkt------------------- 210 Hydrogen...
jgi:Thal_1377       148 LVS----LITHRSKEIYDTSAMLSAFVSYLVSQDSCSLSWEEalsllheiksfarypqhak------------------- 204 Thermocr...
jcvi:cds.PERMA_1427 150 AVV----MLTHRNEIVIDAASVIAVAIGELLQGKFYLEDEYPyfikllktfvqkdetkfy-------------------- 205 Persepho...
jgi:SYO3AOP1_1600   150 ALT----IITSRNEIVLDVSSALAVAIGELIQSRFYLEDEYEyfikllekfvhksetkky-------------------- 205 Sulfurih...

EFC47136            369 ayvpnanqvvnktpenelkwkiyktlpsvnaasevlqelfviiktlratekentllvelrnkisdlarvykpekknmRAH 448 Naegleri...
jgi:Mboo_0067       190 --------------------------------------------------------------aielekegietdtaiLKI 207 Methanor...
jgi:Memar_0150      198 --------------------------------------------------------------avrlanegislesalSVI 215 Methanoc...
EJG06009            198 --------------------------------------------------------------algleqegislegalPSI 215 Methanof...
jgi:HY04AAS1_0374   208 ----------------------------------------------------------mldilidaleegyskekaiVNI 229 Hydrogen...
O66816              214 ----------------------------------------------------------ildrvaellmesadletaiNTL 235 Aquifex ...
BAI68954            211 ----------------------------------------------------------yldrvaellqegadleraiNTL 232 Hydrogen...
jgi:Thal_1377       205 ----------------------------------------------------------vidrvvdllsegadledaiKTL 226 Thermocr...
jcvi:cds.PERMA_1427 206 -----------------------------------------------------------ldrvealikrdasyeeavNEL 226 Persepho...
jgi:SYO3AOP1_1600   206 -----------------------------------------------------------lhkvldllkkeadyetaiNEL 226 Sulfurih...

EFC47136            449 VNQGFCLLAGMHAIACILLpenpeiifhyhkstpEtptpsydsadifnnfPNLLLRSTVT----LGYDTDTIGAILGYLL 524 Naegleri...
jgi:Mboo_0067       208 GNDVSLYQTLPISFFLIRRy-------------qR---------------PADLLTVAAY----VGGNTDTIGFLCGAYL 255 Methanor...
jgi:Memar_0150      216 GNDVTVYQTVPLAFFLINRi-------------kD---------------VTALLTTAAH----VGGNTDTIALICGAYA 263 Methanoc...
EJG06009            216 GSDVSIYQTVPIAFFLMGRy-------------sD---------------PANLLYVAAN----IGGNTDTIAFICGAYI 263 Methanof...
jgi:HY04AAS1_0374   230 GNGNFVLESLGLSLYYFLTegid-------ypfdA---------------FVSAINSYWE----FGGDTDAIGFITGALL 283 Hydrogen...
O66816              236 GNGTFAFEAFPLALYIFLSnv------------eN---------------PEEALFQAVNsygeFGGDTDAIGFLVGAML 288 Aquifex ...
BAI68954            233 GNSTYVFESLPLSLFIFLSni------------dE---------------PMKALWDAVNsygdFGGDTDAIGYLVGAYL 285 Hydrogen...
jgi:Thal_1377       227 GNSTHVLEAFPLSLFIFVRri------------gE---------------PLEALYDAVNcygpFGGDTDAVGYLVGSYL 279 Thermocr...
jcvi:cds.PERMA_1427 227 GNGSYALEALSQALFIFLKtp------------eN---------------TENVIIHAVNsygnYGGDTDSIGLIAGAFA 279 Persepho...
jgi:SYO3AOP1_1600   227 GNGSYCLESFSQALFIFLKtp------------sD---------------VETTIIKAANsygyYGGDTDSISLIAGAFA 279 Sulfurih...

EFC47136            525 GSRFGTSWIPLQ 536 Naegleria gruberi
jgi:Mboo_0067       256 GASKGAGAIPAD 267 Methanoregula boonei 6A8
jgi:Memar_0150      264 GAVYGRSALPPD 275 Methanoculleus marisnigri JR1
EJG06009            264 GAKFGVSALPPD 275 Methanofollis liminatans DSM 4140
jgi:HY04AAS1_0374   284 GAYHGYEFLPED 295 Hydrogenobaculum sp. Y04AAS1
O66816              289 GAYYGEEAIPYH 300 Aquifex aeolicus
BAI68954            286 GAYLGQEIFPLD 297 Hydrogenobacter thermophilus TK-6
jgi:Thal_1377       280 GALHGDEIFPRH 291 Thermocrinis albus DSM 14484
jcvi:cds.PERMA_1427 280 GAYNSEESIPSR 291 Persephonella marina EX-H1
jgi:SYO3AOP1_1600   280 GAYNGEEQIPER 291 Sulfurihydrogenibium sp. YO3AOP1
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