6I1D,2I7T


Conserved Protein Domain Family
RMMBL
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pfam07521: RMMBL (this model, PSSM-Id:377862 is obsolete and has been replaced by 462191)
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Zn-dependent metallo-hydrolase RNA specificity domain
The metallo-beta-lactamase fold contains five sequence motifs. The first four motifs are found in pfam00753 and are common to all metallo-beta-lactamases. This, the fifth motif, appears to be specific to Zn-dependent metallohydrolases such as ribonuclease J 2 which are involved in the processing of mRNA. This domain adds essential structural elements to the CASP-domain and is unique to RNA/DNA-processing nucleases, showing that they are pre-mRNA 3'-end-processing endonucleases.
Links
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Statistics
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PSSM-Id: 377862
Aligned: 99 rows
Threshold Bit Score: 42.9856
Created: 4-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6I1D_A          393 TIPRRCQ-VEEIS-FAAHVDFQENLEFIEKISAPNIILVHGEANPMGRLKSALlsnfaslkG-----------TDN-E-- 456  Saccharomyc...
jgi:Glov_0021   353 KDEVRPGvRYVYAhTSGHAPVEDLQRLVKAVKPRQLVPVHTEFPADYEF--YF--------------------------- 403  Geobacter l...
Q72BD6          353 DPRVSFHeIH----TSGHAFRQDLKRYANAINPKLLVPIHTEKK--QDYAKHF--------------------QP----- 401  Desulfovibr...
jgi:OSTLU_12108 496 EINIRAT-IITVD-FEGKADGKSVRTLITQAAPRRVVLVHGDAKETKTLKDAL--------T-----------AGLpG-- 552  Ostreococcu...
Q55BS1          550 RLPINCK-IQTID-YEGCSDGRSIKAIIQQIAPTKLVLIRGSEQQSQSIENYV--------Ke---------nIRT-K-- 607  Dictyosteli...
CBY19228        544 QVSIRCS-IEFIN-FEGRVDGESQLQLLSTIKPKELILIRTKEKYKEKLFKDI--------Ks----------RVQ-G-- 600  Oikopleura ...
Q2GQR7          706 TVSVQLR-IAFVD-FSGLHDKRSLNMLIPLIQPRKLILVAGAEEETLALAADC--------KkllsaqlasgsSQS-A-- 772  Chaetomium ...
Q9P2I0          528 SIEIKAR-VTYID-YEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAECC--------Ra---------fGGK-D-- 585  human
Q7QC68          528 PIEVNAQ-VQFID-FEGRSDGESLLKILSQLRPRRVVVVRGSPANTSHIAEHC--------------------QQNiG-- 583  Anopheles g...
O17403          562 RVEVSCR-IEFIE-YEGISDGESTKKLLAGLLPRQIIVVHGSRDDTRDLVAYF--------------------ADS-Gfd 618  Caenorhabdi...

6I1D_A          457 VHVFN-P 462  Saccharomyces cerevisiae S288C
jgi:Glov_0021   404 GNCLM-V 409  Geobacter lovleyi SZ
Q72BD6          402 IQVKA-V 407  Desulfovibrio vulgaris str. Hildenborough
jgi:OSTLU_12108 553 VQIDA-P 558  Ostreococcus lucimarinus CCE9901
Q55BS1          608 -GIYI-P 612  Dictyostelium discoideum
CBY19228        601 IRIHM-P 606  Oikopleura dioica
Q2GQR7          773 IDVFT-P 778  Chaetomium globosum CBS 148.51
Q9P2I0          586 IKVYM-P 591  human
Q7QC68          584 ARVFT-P 589  Anopheles gambiae str. PEST
O17403          619 TTMLKaP 625  Caenorhabditis elegans
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