Conserved Protein Domain Family
DUF4592
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pfam15262: DUF4592 (this model, PSSM-Id:405859 is obsolete and has been replaced by 464602)
Domain of unknown function (DUF4592)
This protein family is a domain of unknown function, which lies to the N-terminus of the protein. This domain family is found in eukaryotes, and is typically between 114 and 130 amino acids in length. There are two completely conserved residues (L and A) that may be functionally important. In humans, the gene that encodes this protein lies in the position, chromosome 2 open reading frame 55.
Links
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Statistics
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PSSM-Id: 405859
Aligned: 21 rows
Threshold Bit Score: 54.0936
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Download Cn3D
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_005037640  128 PTMKLGP----------PPPFgLHAKRTDDAGTSS-EDDGLPRSPPEMSLLHESLISGMRTR---------FSD------ 181  Collared flyc...
XP_015201228   44 HNIKFGQ----------KPTS-TSFRRSDAAEGSS-DDEDVPRSPLKVVAQIEAEPVDTEMK---------DSA------ 96   spotted gar
XP_020957017   19 KNIKFGQ----------HPPSaIPMKKADSGEPRF-EEHPFLTCPVESVPEQALVLVDTESK---------PSE------ 72   pig
XP_017202756   38 KNIKFGQ----------RPANaLPVRKADGGEASL-EEGPLLPRPMETQTPWDVVLSDTENK---------AGH------ 91   rabbit
XP_010708422   45 KNIKFGQ----------PPQMtISGRTMGEANASV-EEDMFLGSLMEIDSQQDTVLSESGNK---------SAD------ 98   turkey
ELK18871      127 SKITEIPplrlcqpgisPFYI-KSDTISKDFEEISvDDDESPKTPQKKLLPQNILM------------------------ 181  black flying fox
XP_016153505  115 KNIKFGQ----------PPQMtVSARTMGEANASA-EDDALLSSPMETETQQDTVISDCSNK---------STD------ 168  collared flyc...
XP_025758974   19 QGIKFGQ----------RP---PSLRRSEGDEGSS-DEEEVPRSPLKVLAQVEAEPLRTEPK------------------ 66   Nile tilapia
TWW57596      128 QGIKFGQ----------RP---PSLRKSEEDEGST-DEDEAPQSPLKVLAQVEPEPSNTESKvygtqqvepHST------ 187  sansaifugu
XP_004911258   45 GNIHFGL----------RPDS-IPRKRMQGLGASTgEMDTSHISPMEIg-----gEQDKGPQ---------QKAatmvtg 99   tropical claw...

XP_005037640  182 SHKHLSSLSLAGTGSEEEEQITLg-----SSSRSRSTDgqlftrhgstSTESPRt--STDSTISPTaNFDTPPELSAFLD 254  Collared flyc...
XP_015201228   97 DLPKNGHTTEASTRTSEVKQ--------------DTPV----------KSPRQRravLASGTIESI-NLDAVPRSASRLD 151  spotted gar
XP_020957017   73 TPGTPSPLNLPAARSEMEEK--------------AAPV----------KPSRPKrlfSSAGTIESV-NLDAIPLAIARLD 127  pig
XP_017202756   92 TPGSPGAVNPPGGGSDMEEK--------------VAPV----------KPSRPKrhfSSAGTIESV-NLDAIPLAIARLD 146  rabbit
XP_010708422   99 TPDLLRPMNLPGTG-QMEEK--------------VTPV----------KSSRPKrqfSCSGTIETI-NLDAVPQAVVRLD 152  turkey
ELK18871      182 ----LKKSSLEPSSGPVHSQPYTafamltSPSSTQLPI-----------------------------GFSTPATTQGYLD 228  black flying fox
XP_016153505  169 TPDFLRKMNFLGPGHEMEEK--------------VTPV----------KSARPKrqfSCSGTIETI-NLDSVPQALARLD 223  collared flyc...
XP_025758974   67 ----------------QVQGGQP-------FGPHSPPV----------KSPRSKrvlPLTGTIESI-NLDAVPQSVPRLD 112  Nile tilapia
TWW57596      188 PVKS-----------PRTKC--------------ALPP---------------------TGTIESI-NLDALPQSAPRLD 220  sansaifugu
XP_004911258  100 SPSSFSSMNNIELEHKTEEK--------------VTPV----------KPSRSKrpfAVSGTIESI-NLDAVPRSVDRLD 154  tropical claw...

XP_005037640  255 NSAAKHKLLIKPRNQRFSR 273  Collared flycatcher
XP_015201228  152 NTAAKHKLAIKPKNQRASK 170  spotted gar
XP_020957017  128 NSAAKHKLSVKPKNQRVSR 146  pig
XP_017202756  147 NSAAKHKLAVKPKNQRVSK 165  rabbit
XP_010708422  153 NSAAKHKLSVKPKKQRMSR 171  turkey
ELK18871      229 SSGAPHMMVLNPQNQKKNl 247  black flying fox
XP_016153505  224 NSAAKHKLSVKPKKQRMSR 242  collared flycatcher
XP_025758974  113 NAAAKHKLSVKPKNQRVSR 131  Nile tilapia
TWW57596      221 NAAAKHKLSVKPKNQRISR 239  sansaifugu
XP_004911258  155 NTFAKHKLSVKPKNQRVSK 173  tropical clawed frog
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