Conserved Protein Domain Family
DUF5601
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pfam18151: DUF5601 (this model, PSSM-Id:407982 is obsolete and has been replaced by 465668)
Domain of unknown function (DUF5601)
This domain is found in the catalytic core RABEX-5 present in Homo sapiens. RABEX, also known as Rab GTPase exchange factors, regulate endocytic trafficking through activation of the Rab families RAB5, RAB21 and RAB22. The domain is helical in nature.
Links
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Statistics
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PSSM-Id: 407982
Aligned: 35 rows
Threshold Bit Score: 55.2896
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
OWR43127      144 RECRVFVHRF--IwdvinsSY--VMSVDELSERVQRYYQQFIKYTDNSPHLVSAEPE-LKERLIDFVEKHAMTYLH 214  Danaus plexippus ...
XP_006114374 1246 KKIREFIQDF--Q------RL--TA-ADDKTAQVEDFLQFLYGAMAQDVIWQNASEE-QLQDAQLAIERSVMNRIF 1309 Chinese soft-shel...
XP_001635426  122 KEINTFINGF--R------SN--CPTPDEKCRFVEQFLEKLYTELDQDEVWLGASDD-HREEGYIAIERDIMGRIY 186  starlet sea anemone
KXN72567      172 KYLESFVRKF--D------QL--SSSVSQQVKMVNEFSQFILSKMLQTEVWHDVDDS-QLDFLREGVEQYLMNRLH 236  Conidiobolus coro...
XP_009269717   41 KYTLSFLSGF--E------KR--DFTSTQQVKLISDFLSFIAAEMRKSNQFD------DLDLALDSIDKLIHIKLY 100  Wallemia ichthyop...
XP_020069498   36 RYIKSFLKNF--T------QR--SFTVDEQVKIFDDFEEFIFARMAEYEPFSTMDEV-SFENAKAGVEKLVMTKLF 100  Cyberlindnera jad...
XP_013935928  223 KYLRSFLTQF--S------QR--TWTVDEQVKLIKDFEAFLYDKLLQYYPFNTIQDElELDNCKEGLEKLVLTRLY 288  Ogataea parapolym...
CCE78196      344 RYIRSFLISF--N------KQshTFTSVQKVKIINDFKTFMNEKFNLYEPFASMDDV-DLENSREGLEKLIMNRLY 410  Millerozyma farin...
P54787         80 KYTKSFLRNFlaQ------RL--LWTVSEEIKLISDFKTFIYDKFTLYEPFRSLDNS-KMRNAKEGMEKLIMGKLY 146  Saccharomyces cer...
XP_001750916  350 KPIRDFIGRF--T------QP--VHNPDEAVQPIRDFLDKINHDLANHELWRDATDA-DLEYGYEGMEKYIMSKLY 414  Monosiga brevicol...
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