2W96


Conserved Protein Domain Family
CYCLIN_CCND1_rpt1

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cd20573: CYCLIN_CCND1_rpt1 
Click on image for an interactive view with Cn3D
first cyclin box found in G1/S-specific cyclin-D1 (CCND1)
CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.
Statistics
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PSSM-Id: 410276
Aligned: 7 rows
Threshold Bit Score: 283.794
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
CDK interfaceD-type cyclin
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:CDK interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ## ##  #                #  ##                                                
2W96_A         3 HQLLCCEVETIRRAypDANLLNDRVLRAMLKAEETCAPSvSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAM 82  human
1705781        3 HQLQCCEVETIRRAylDANLLNDRVLQTMLKAEETCSPSvSYFKCVQKEILPYMRKIVATWMLEVCEEQKCEEEVFPLAM 82  chicken
Q90459         3 HQLFCCEVDTIRRAyqDSNLLNDRVLQTMLKAEENYLPSpNYFKCVQKEIVPKMRKIVATWMLEVCEEQKCEEEVFPLAM 82  zebrafish
P50755         1 MELLCCEVDTIGRAhlDRNLITDRVLQTMLKAEETSCPSmSYFKCVQKEILPNMRKIVATWMLEVCEEQKCEEEVFPLAM 80  African clawed ...
P24385         3 HQLLCCEVETIRRAypDANLLNDRVLRAMLKAEETCAPSvSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAM 82  human
AFK11583       3 HQLLCYEVETIRRAykDPNLLNDRVLQTMLRTEENCLPSlSYFKCVQKEILPSMRKIVATWMLEVCEEQKCEEEVFPLAM 82  elephant shark
XP_005996284   3 NQLLCCEVETIRRAyhDPNLLNDRVLKTMLKAEENSPPSvSYFKCVQKEILPYMRKMVATWMLEVCEEQKCEEEVFPLAM 82  coelacanth
Feature 1                                 #   ## #  # ##                #  ##   #  ###
2W96_A        83 NYLDRFLSLEPvKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWN 151 human
1705781       83 NYLDRFLSFEPlKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPDELLQMELLLVNKLKWN 151 chicken
Q90459        83 NYLDRFLSVEPtKKTRLQLLGATCMFLASKMKETVPLTAEKLCIYTDNSVRPGELLQMELLALNKLKWD 151 zebrafish
P50755        81 NYLDRFLSVEPlRKSWLQLLGATCMFLASKMKETIPLTAEKLCIYTDNSIRPDELLIMELRVLNKLKWD 149 African clawed frog
P24385        83 NYLDRFLSLEPvKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWN 151 human
AFK11583      83 NYLDRYLSIELtKKTHLQLLGATCMFLASKMKETIPLTAEKLCIYTDNSIKPEELLQMELLVLNKLKWD 151 elephant shark
XP_005996284  83 NYLDRFLSVEPiKKNRLQLLGATCMFLSSKMKETIPLTAEKLCIYTEHSIRAEELLQMELLVLSKLKWD 151 coelacanth

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