4A04


Conserved Protein Domain Family
T-box_TBX1_10-like

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cd20187: T-box_TBX1_10-like 
Click on image for an interactive view with Cn3D
DNA-binding domain of T-box transcription factor 1 and 10, and related T-box proteifactors
This subfamily includes TBX1 and TBX10. TBX1 is a T-box transcription factor which plays an important role in heart development and has been implicated in DiGeorge or 22q11.2 deletion syndrome. This syndrome is associated with various types of cardiac outflow tract (OFT) and vascular defects. Wnt5a is regulated by TBX1 in the second heart field (SHF). TBX1 is required to maintain the integrity of extracellular matrix-cell interactions in the SHF and this interaction is critical for cardiac (OFT) development. TBX10 is a putative T-box transcription factor. Diseases associated with TBX10 include Isolated Cleft Lip and Cleft Lip/cleft lip with or without cleft palate. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.
Statistics
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PSSM-Id: 410313
Aligned: 20 rows
Threshold Bit Score: 350.186
Created: 8-Mar-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA binding
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:two TBX1 T-box monomers dimerize upon DNA binding; they appear to bind as non-associating monomers, the T-box dimer is kept in register by the DNA
  • Structure:4A04; Homo sapiens TBX1 monomer binds DNA, contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                              #     ##                                #                 
4A04_A        15 GVSVQLEMKALWDEFNQLGTEMIVTKaGRRMFPTFQVKLFGMDPmADYMLLMDFVPvDDKRYRYAFHSSSWLVAGKADPa 94  human
NP_511085    195 QAIVVLETKALWDQFHAQGTEMIITKtGRRMFPTFQVRIGGLDPhATYICMMDFVPmDDKRYRYAFHNSCWVVAGKADPi 274 fruit fly
XP_013413512 146 HVTSDLEMRQLWREFDELGTEMIVTKaGRRMFPTFQVRLFGLDPmSDYMLVMDFIPcDDKRYRYSFHTSSWVVASKADPh 225 Lingula anatina
EFX85047       6 GVNASLEMKALWDEFNELGTEMIVTKaGRRMFPTLQVRLFGLDAnSDYMLMMDFVPvDDKRYRYAFHSSSWVVAGKSDPn 85  common water flea
AGG11863     192 AVEAKLEMKSLWDEFNDLGTEMIVTKaGRRMFPTFQVKVFGLDVnSEYILMMDFTPvDDKRYRYAFHTSSWSVAGKADAa 271 vase tunicate
NP_001310757  98 NINGTLETKSLWDEFNELGTEMIVTKaGRRMFPTFQVKLYGMDPmADYILMMDFVPvDDKRYRYAFHSSSWVVAGKADPn 177 common house sp...
ACY92663      48 YVEVQLEMKGLWDEFHVLGTEMIVTKsGRRMFPTFQVKIRGMDPmAEYILMMDFVPvDSKRYRYAFHSSSWLVAGQGDPe 127 Saccoglossus ko...
SJX71985     112 HVRVELEMKSLWDEFHSLGTEMIVTKaGRRMFPTFQVRLYGLEPsAKHILMMDFVPvDDKRYRYAFHSSKWLVAGKADPs 191 starlet sea ane...
PIK50615     197 TVEARLEMKPLWDEFHSLGTEMIVTKaGRRMFPTFQVKMSGMDPmAEYILLMDFVPvDDKRYRYAFHSSSWLVAGKADPe 276 Japanese sea cu...
KRX49515      46 NVQLNLEMHDLWIQFSQLGTEMIVTKsGRRMFPTLQISITGMDPkRLYNVMVDFVPlERKRYRYSYHRSSWIVAGPSDPe 125 Trichinella mur...
Feature 1                                    #  #            ##                                  
4A04_A        95 tPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVDprkds----ekyaeENFKTFV 170 human
NP_511085    275 sPPRIHVHPDSPAVGSNWMKQIVSFDKLKLTNNQLDENGHIILNSMHRYQPRFHLVYLPpknasl--denehsSHFRTFI 352 fruit fly
XP_013413512 226 mPGRIHVHPDSPAKGAQWMKQVVSFDKLKLTNNLMDENGHIILNSMHKFQPRFHVIYVNpkaed-----vsqcQTYKTFV 300 Lingula anatina
EFX85047      86 sPPRIHVHPDSPAKGSQWTKQVVSFDKLKLTNNQLDDNGHIILNSMHRYQPRFHVVYINqrted-----asqtENFRTFI 160 common water flea
AGG11863     272 mPPRIHVHPDSPAKGGHWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRFQPRFHVVLVDnshds----vqraeENFKTFV 347 vase tunicate
NP_001310757 178 mPPRMHLHPDSPAKGTQWMKQVISFDKLKLTNNQMDDNGHIILNSMHRYQPRFHVVYVNpkged-----asqtQNFKTFV 252 common house sp...
ACY92663     128 mPGRIHVHPDSPARGSIWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVHVSgrkdp----enapeRDFNTFL 203 Saccoglossus ko...
SJX71985     192 vPGRVHIHPDSPCTGAQWMKQIVSFDKLKLTNNLMDDNGHIILNSMHKYQPRFHVILEDpdrsstaslhevskDHIRTFI 271 starlet sea ane...
PIK50615     277 mPGRIHVHPDSPARGALWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVHVSgrkdf----ddapeRDFKTFF 352 Japanese sea cu...
KRX49515     126 lPPRVHFHPDSPALGSHWMRQVVNFDKLKITNNQMDPNGYIVLNSMHQYQPRIHVSMMNkcsfe-----deayETMKTFI 200 Trichinella mur...
Feature 1                 ###             #  ##  #######  
4A04_A       171 FEETRFTAVTAYQN--------HRITQLKIASNPFAKGFRD 203 human
NP_511085    353 FPETSFTAVTAYQN--------QRVTQLKISSNPFAKGFRD 385 fruit fly
XP_013413512 301 FIETKFTAVTAYQN--------HRITQLKIASNPFAKGFRD 333 Lingula anatina
EFX85047     161 FPETKFTAVTAYQN--------HRITQLKIASNPFAKGFRD 193 common water flea
AGG11863     348 FDETKFTAVTAYQN--------HRITQLKIQSNPFAKGFRD 380 vase tunicate
NP_001310757 253 FAETKFTAVTAYQN--------HRITQLKIASNPFAKGFRD 285 common house spider
ACY92663     204 FSETQFTAVTAYQN--------HRITQLKIASNPFAKGFRD 236 Saccoglossus kowalevskii
SJX71985     272 FPETQFMAVTAYQN--------HMITQLKIASNPFAKGFRE 304 starlet sea anemone
PIK50615     353 FSETQFTAVTAYQN--------HRITQLKIASNPFAKGFRE 385 Japanese sea cucumber
KRX49515     201 FPETVFMAVTAYQNqraitvkhFQITNLKIASNPFAKGFRD 241 Trichinella murrelli

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