Conserved Protein Domain Family
RB_B

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pfam01857: RB_B 
Retinoblastoma-associated protein B domain
The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B domain. The B domain has a cyclin fold.
Statistics
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PSSM-Id: 460363
Aligned: 74 rows
Threshold Bit Score: 118.821
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFX76662                       739 SLSLFFRKFYHLASVRLQDLCNRL---ELYEe----DLRKK---------------------IWTCFEFSVMKHSDLMQD 790 
Q54FX2                         889 FIQNFIKKVSTLIIAKCRKLIHAM---GLSS-----DYVVQ---------------------IYQVMIKILIDETLLFKN 939  Dictyostelium discoideum...
CBI21251                       331 GIKLLFEKVAKLAAVRINHLTLRL---KPLQ-----PIREI---------------------VYGLFHRILNQKTALCFN 381 
EEF49309                       363 AINVLFSKMAKLGAIRTQSIAERL---KLSK-----QFREK---------------------VYFLFQQILNQRTTLFFN 413 
EEH52586                      1035 SLRIFFAKVMRLSARRLADLCDRL---SLPS-----SLTQQ---------------------AYSLVEHALYDNTSLLYN 1085
XP_001421627                   745 ALRMFFAKVMHLAARRLGDLASRL---NLST-----DVTRD---------------------IYALIEHVVYEQTNLVYN 795 
EDP08606                       814 LLFEFLRKVLKLTSFRLALLCENF---DFSPle-gpEVNSK---------------------VYEAIEHALYKQTHLFYN 868 
XP_002954473                   774 FCCKVRKQVLKLAAFRLAVLCDNF---DFSPlq-rlDVNTKv-------------------wVYQTIEHALFFQTHLFYN 830 
EFN55837                       548 AVNKFLRRVLKLAAIRLADLLSRLdthPADPhvllaEVRRRqgaglglakaglglahsggiaAFTLAQHVAFEQTWLLYG 627 
WGS:AAGF:cds.TTHERM_00439030A  589 AIEKFFRRVLHQCAYTINQVCSAL---KLND-----KISEA---------------------VWRIMKHILANQSDILLG 639 
EFX76662                       791 RHLDQILMCAVYVICKVT------GRDKNFTDIMRCYRTQPHASSHVYRSVLLCTkarrgsaseeDdeaatgstvkvngd 864 
Q54FX2                         940 REIDVLLICSIYAICKVN------SKNITFKAIID----KSCISAKVYKEVYIGNdennnnnnnnNnnnnnnnnnnnnni 1009 Dictyostelium discoideum...
CBI21251                       382 RHVDQIILCCFYIIVKDS------KLELTFKEIKDSYVKQPQHGPQVVSHVFVNRspahg-------------------- 435 
EEF49309                       414 RHMDQIVLCCFYGLAKMS------GVNLTFKQIYDNYMKQPQCRSQIFWSV---Sgnhe--------------------- 463 
EEH52586                      1086 RHLDQIILCAVYGTCKVNkdgalkGKTVPFRDIIYHYQKQPQCREEVFWTVVMSQsdp---------------------- 1143
XP_001421627                   796 RHIDQIILVSVYGVCKASag--isSNSLQFKDIIYQYSKQPQSSEEIFWAVVLEQndp---------------------- 851 
EDP08606                       869 RHIDQIMLSTLYGYCKVHk-----LSQVSFREIIAQYRKQPQAQQSIFRSVVIDQvlp---------------------- 921 
XP_002954473                   831 RHIDQIILSALYGFCKVHr-----LAQVSFREIIAHYRKQPQAQPSIFRSVVVEQsnpsl-------------------- 885 
EFN55837                       628 RHLDQALLCCLYSVCKLHq-----LGQASFKAIIAAYKQQAQAQADTFKSVSMRPrehtt-------------------- 682 
WGS:AAGF:cds.TTHERM_00439030A  640 RHIDQLVICSIYIMCKLF------KSETIFKQILNKYE-ELNSHNKAMMRELIYAmp----------------------- 689 
EFX76662                       865 ekkaetngekalppvrssstlpfpqpsscpptptglagtsssfEYEDRGDLILFYNTVYVRRLQ 928 
Q54FX2                        1010 ------------------------------nnnnnnnennnnnNNPVKGDIILFYNKIFLTKMD 1043 Dictyosteliu...
CBI21251                       436 ----------------------------------------ngknREDHIDIVAFYNEIFLWAVK 459 
EEF49309                       464 ------------------------------------------rnggQYAEMITFYNRIFLPSVK 485 
EEH52586                      1144 -----------------------------------------eleVITQGDIIAFYNKVFVPAVK 1166
XP_001421627                   852 -----------------------------------------eleVVNRGDIISFYNKVFVGRVK 874 
EDP08606                       922 -----------------------------------------tlqIQSRADIIGFYNAVFVPAMR 944 
XP_002954473                   886 ----------------------------------------qvgqVGRRADIIAFYNQVFVPCMK 909 
EFN55837                       683 ---------------------------------------lhqlhPTATADIITFYNQAGGAGQA 707 
WGS:AAGF:cds.TTHERM_00439030A  690 ------------------------------------------iaPNKLDTIVSYYNNVYLGFVK 711 
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