Conserved Protein Domain Family
Bile_Hydr_Trans
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pfam04775: Bile_Hydr_Trans 
Acyl-CoA thioester hydrolase/BAAT N-terminal region
This family consists of the amino termini of acyl-CoA thioester hydrolase and bile acid-CoA:amino acid N-acetyltransferase (BAAT). This region is not thought to contain the active site of either enzyme. Thioesterase isoforms have been identified in peroxisomes, cytoplasm and mitochondria, where they are thought to have distinct functions in lipid metabolism. For example, in peroxisomes, the hydrolase acts on bile-CoA esters.
Links
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Statistics
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PSSM-Id: 461422
Aligned: 132 rows
Threshold Bit Score: 68.4138
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
jgi:Spiaf_0764        32 DEKIILSIHGSESGEKVEVQFQTAD---------NNGDL-WQSRATFSANENGIVDFGSAAPQSGSYSGVDPM--GMFWS 99 
WP_013487962          13 DEPLQLHMDGLKPNETITLTLKMKY---------E--QVmWTSTTTTAADDNGKLS-------IGSADGKSNIlsELLWK 74  Evansel...
WP_013371072          13 DEKIDFCVTGLPPEDKMKITASMHFpw-------aVSEK-YQSFAWFTADSNGSVDLSKHKPDSGTYDYIDSM--GLIAS 82  Paeniba...
goetting:Cspa_c38000  13 TEKIDIKVLELMPNSKVKITLKAELpw-------cSGEE-YSSYGVFISNEKGEVDLDLIEPIEGTYKAKDSM--GLIYS 82 
Q187S7                13 DERLKIMVSDLIPNTKLKISVKMEFpw-------cKGEE-FSSYGVFCSNEKGEVDLDLVEPIEGTYKADNCM--GLIYS 82  Clostri...
zhongguo:DGo_CA0537   18 SRRFFLRAWALPPKTEVTVGTAAPD---------RHGAC-WQAEATYRTTAAGALDLSAQPALTGRFRGVDPA--GPIWS 85 
Q8DV73                15 DSPFELIIERLPPCCQVKVRLDLDHyyninapmnLSSQApWQAEALFYSDDKGILDLSE----SNPYHNLSIM--ELFFK 88  Strepto...
XP_003116013          12 AETVKISASKLTPFQGYKFH-LRLN---------HEGKL-LRSYCVIKSDKDGTIDLSRDAPVRGTYHEVDSM--GLFRT 78 
XP_002635796          12 TEKLKISASGLTPFSNYKLE-LRLH---------SDNGI-LRSYCILKSDEHGKIDLPSAKPIRGTYLDADPM--GLFLT 78 
EFO95048              12 AEKVHISASGLNPFQCYKFQ-LRLN---------YKHGT-LQSYCVIQSDKDGKINLVKDKPIRGTYHEADPM--GLFLS 78 

jgi:Spiaf_0764       100 MEPIEDNH------QTITYQPPeSGME-VDISVQ-SESGARGRATISRSVGEHSIQIDWVSE 153
WP_013487962          75 MHPQSKQQh----kSLFNEDISqLTLH-IDIEAE--ESQRKEARTITRMFKEDYVHEEQLPD 129 Evansella cellulosilytica
WP_013371072          83 L-----QKinseggNIAHNISIdGSLF-IDIVCE--NGQDRECIRLERMFKLPEVKRHQITD 136 Paenibacillus polymyxa
goetting:Cspa_c38000  83 L-----KKtrtvgkNIAENISIdKPMI-MHMIFE--TSDEKKELELKRIFKTDDVIVKNICE 136
Q187S7                83 L-----EKsktegkNFAENISIdKPII-MNMIFE--TSIERKEVELKRIFKSEDITTKYISD 136 Clostridioides difficile 630
zhongguo:DGo_CA0537   86 LRPRPDHTp-----AFFEAPEAgVTLT-VRLSAG---ERVLEETTVRRLTHSPDLHETPVRE 138
Q8DV73                89 SQPIVCKKak---lSQQLESIPlNPFYdLKISIF-KGHSLLGETSVRRYYQLPSISCLDLNF 146 Streptococcus mutans
XP_003116013          79 VELTDDVTl-----GTYVSNPMaTPFF-YKLQLIsESEEIIDEVNMKKRWTHPSVIQVDIVQ 134
XP_002635796          79 LERTDDVPf-----GDMVRNPDaVPFF-YTLRLLsESEKLLDEVNLKKRWLHPSVTEIEVKQ 134
EFO95048              79 VQFTDELSf-----GHLVMNENaEPFF-YTLRLIsESEEILDEVNMKKHWTHPLVTQIAVSQ 134
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