3T6G


Conserved Protein Domain Family
CAS_C

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pfam12026: CAS_C 
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Crk-Associated Substrate C-terminal domain
This is a C-terminal domain found in CAS family members. The CAS (Crk-Associated Substrate) protein family is a group of scaffolding proteins that play important modulatory roles in both normal and pathological cell growth regulation. They contain an N-terminal Src homology 3 (SH3) domain pfam00018 and a substrate domain (SD). The SD contains a large number of YxxP motifs, which when phosphorylated by Src-family kinases provide canonical binding sites for proteins containing SH2 domains such as Crk, Crk-L, CRKII presumed domain is functionally uncharacterized.
Statistics
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PSSM-Id: 463437
Aligned: 35 rows
Threshold Bit Score: 189.904
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3T6G_B        11 ENSEGGWMEDYDY-----VH----------LQGKe-----EFEKTQKELLe------------------------kGSIT 46 
XP_004918780 645 PLPRQKTVDDSDY-----VH----------LQKKe-----EFERAKAIFShqqlenkiqt------eekrkgwitpESLI 698
5_pfamImport   1 ETTKENVTEDCEY-----VQ----------LQAQkiisgkEVSKKSTDLKpkvflilktmaykesqsfisvlakiqRNMV 65 
XP_023394560 614 KQETLQLAPNAEFklkkcIQ----------LPQRe-----NESYQRSTPFnkqre-----------------ndhfPELV 661
A5GFW5       591 KEEPVQWTPNAEFklarrIQ----------LPQKe-----GESYQRKAPFqkqra-----------------seqpPELI 638 pig
EFB30235     596 ELAKC-------------IQ----------LPQRe-----IESYQRSAPFskqke-----------------sehsPELL 630
8_pfamImport   1 NISKENVIEDCDY-----VQ----------LQKKs-----KFSAQEKSLRt------------------------kEHFW 36 
AAI46253     371 EYEGIPVAEEYDY-----VH----------LKGMd-----KVQEARPPDKaspgd-----------------peqlEREP 413
XP_013221179 592 KEETIQLSP----------NaeftckkgiqLPQRe-----VESYQKRAPFnkare-----------------nyhsPEVL 639 thirteen-lined ...
XP_005010473 668 QKTKDDDIEDCEY-----VQ----------LQVLps--------------------------------------skKNVI 694 mallard
3T6G_B        47 RQGKSQLELQQlkqf---erleQEVSRP-----IDhDLAN--WTPAQ---------------------PlapgrtgGLgP 95 
XP_004918780 699 SGSEKQEKKDE-----------LPTIK---------EPSS--PTPKQdvahsp----------espkkF-------NL-- 737
5_pfamImport  66 RMEECSVE----------------------------QVLP--STKKNavrsqq--------------------------- 88 
XP_023394560 662 KKNKTNVCGQKlpnleekekhiSKQRVDknkdlRTkNPST--LLPQPlslqn------------pekkI-------HL-- 718
A5GFW5       639 EKNKTNACG-----------------Q---------NPGS--LIPRPlsqqn------------pekrI-------HL-- 669 pig
EFB30235     631 KKNGTIIR--------------------------EpNPSS--LIPQPlsqqn------------pekrF-------HL-- 661
8_pfamImport  37 AFLKYPMC------------------------------HP--QVSQDyqkvpialsmpqkndkkkwktS-------ASkP 77 
AAI46253     414 PEQQEALS-------------------Pg----ES---------------------------------L-------VLpT 430
XP_013221179 640 KKNGTSAPe---------------------------QNPGclVAQPLtqqn-------------pgrkV-------HL-- 670 thirteen-lined ...
XP_005010473 695 QSKQEPAKk-----------------------------------------------------------I-------AL-- 706 mallard
3T6G_B        96 SDRQLL---------LFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVR 166
XP_004918780 738 ------------------SEHSCLYFGALQKAIGVFNNSLSNNQPPEIFITHGKLIIMVGQKLV---DSVCQDVKSSEVR 796
5_pfamImport  89 ----------dsakkIVVPEQCRLCFGALHKAIAVFNNSLSSNQPPEVFISHSKLIIMVGQKIV---DCLCQEAQLREAR 155
XP_023394560 719 ------------------SEHCRLYFGALFKAISVFTSSLSNSQPPENFITQSKLIIVIGQKLV---DTLCKETQERDAR 777
A5GFW5       670 ------------------SEHCRLYFGALLKAIGVLNGSLSNRQPPETFITQSKLIIMVGQKLV---DTLCKETQERDFR 728 pig
EFB30235     662 ------------------SEHCRLYFGALFKAIGVFNSSLSNSQPPEIFITQSKLVIMVGQKLV---DTLCKETQERDVR 720
8_pfamImport  78 SETHGIptkkdvpskVHYSEHCKLYFGALHKALSVFKNSLSNNQPPEVFISHSKLVIMVGQKLV---DTLCREVQGKDIQ 154
AAI46253     431 GDLQLL---------HFYAGQCQGHYSTLQAAVAALMSSTQAKQPPHLFVPHGKRALVAAHRLVFVGDTLGRLAASAPLR 501
XP_013221179 671 ------------------SEHCRLYFGALFKAISVFHSSLSNSQPPEIFITQSKLVIMVGQKLV---DTLCKETQEKDVR 729 thirteen-lined ...
XP_005010473 707 ------------------PEHCRLCFSALQKAIAVFNNSLSNNQPPEVFISHSKLIIMVGQKIV---DSLCQETQERDAR 765 mallard
3T6G_B       167 SQVTHYSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVERVKELGHSTQQFRRVL 221
XP_004918780 797 NDVLFKSSELCGLLKNLALATKTAAIQYPNPAALRDMETRMDELLKHTQIFRAMA 851
5_pfamImport 156 SDILHSSSRFCSLLKNLALATKNAAIQYPNADAMRELQNKSDELHKYAQQFRAML 210
XP_023394560 778 NEILGCSSHLCSLLKNLALATKDAVLQYPSPEALRHLQAEAETLERHTRQLRQAL 832
A5GFW5       729 NEILCGSSHLCSLLRNLALATKHAVLEYPSPAALGHLQAEARKLEQHTQQFRGTL 783 pig
EFB30235     721 NEILCGSSHLCSLLKSLALATKQAVLKYPSPAALGHLQTEAQKLEQHTRQFRGTL 775
8_pfamImport 155 NDVLYSSSQLCSLLKNLALSTKKAAVQYPNPTAVQELQDRVQELSQHAEQFRSLL 209
AAI46253     502 AQVGAAGTALGQALRATVLAIKGAALGYPSSPAAEEMAQCVADLAGQALQFTTLL 556
XP_013221179 730 NEILCSSSHLCGLLKDLALATKNAVLKYPSPAALGHLQAEAKKLENHTRQFRGTL 784 thirteen-lined ground squirrel
XP_005010473 766 NDILHSSSRFCSLLKNLALATKNAAIQYPNADAMKELQNQNDELYKYTQQFRAMM 820 mallard
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