Conserved Protein Domain Family
Dapper

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pfam15268: Dapper 
Dapper
This is a family of signalling proteins. They act in a diverse range of signaling pathways and have a range of binding partners. They act as homo- and heterodimers.
Statistics
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PSSM-Id: 464605
Aligned: 26 rows
Threshold Bit Score: 611.724
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007238563  25 ERLQAALAGLQELHHLREKQSDMVRWALrlDreqpasspAVNPRDSD---------------------SS--------SE 75 
XP_007484975  24 ERLHAALAGLQELQVLRDKQQALVSGALamQpaapppppPPPQSEPQppvprppwlphllpsvlpagdSH--------SK 95 
NP_001100934  19 ARLRAALAGLQELQGLRATQQARVRGALglHpa---------------------------------pgPR--------GQ 57 
XP_003792465  20 ARLRAALAGLHELQGLRATQQARVRGALamQhppgpappPG---------------------------PR--------GQ 64 
XP_001083736  20 ARLRAAFAGLQELQGLRATQQERVRGALalQpppapaapCGPHG------------------------PH--------GP 67 
XP_006638824  31 ERLQAALAGVQELHLLKERQSGMVQWALqmArekpalvpHPDAGDPG---------------------GS--------TD 81 
2_pfamImport   1 ERLQAALAGLQELRLLKDRQGDMVSWALgvDreepvssvQAGPEDPDm--------------------MG--------VE 52 
XP_017827047  20 ARLRAALAGLLELQGLRAAQQERVRDALalQpppapaapTAPWG------------------------PH--------GH 67  white-tufted-ea...
XP_005321496  20 ARLRAALAGLHELRGLRAAQQARVQGALamQ-------------------------------------PApagprgpsGQ 62  thirteen-lined ...
XP_006011471  24 QRLQAALAGLQELQLLRERQGGVVQEALrmQgdspkqtgEEGIGD-----------------------GY--------LE 72  coelacanth
XP_007238563  76 EQRLEATLTALKQQLTRLRRQDVGLKTHLQQLDQQISELKLDVCKASAEHLESDSRPSSGFYELSDGGLGSLSNSCTSLY 155
XP_007484975  96 EHRLEATLTALKEQLSRLRRQDVGLKTHLDQLDQQISELKLDVNKTSSENLDSDSRPSSGFYDLSDGGSCSLSNSCTSVY 175
NP_001100934  58 ELRLEAALAALREQLSRLRRQDAGLKTHLDQLDQQISELQLDVSRSPCEALDSDSRPSSGFYELSDAGSCSLSTSCASVC 137
XP_003792465  65 ELRLEAALAALQEQLSRLRQQDAGLKTHLDQLDQQISQLQLDVGAPPGEALDSDSRPSSGFYELSDGGSCSLSTSCASVC 144
XP_001083736  68 EQQLEAALAALQEQLSRLRQQDIGLKTHLDQLDLQISKLQLDVGTASGEALDSDSRPSSGFYEMSDGGSCSLSTSCASVC 147
XP_006638824  82 EQRLEATLAALKEQLSRLRRQDVGLKSHLQQLDQQISELKLDMSKASSEHLESDSRPSSGFYDLSDGGSVSLSNSCTSVY 161
2_pfamImport  53 EQRLEATLTALKQQLSRLRKQDVGLKTHLQQLDQQINELKLDVNKATTDQLESDSRPSSGFYELSDGGSCSLSNSCTSVY 132
XP_017827047  68 EQQLEAALAAVQEQLSQLRQQDIGLKTHLDQLDLQISKLQLDLGTTSGEALDSDSRPSSGFYELSDGGSCSLSTSCASVC 147 white-tufted-ea...
XP_005321496  63 ELRLEAALAALQEQLSQLRRQDTGLQTHLDQLDQQISELQLGVHRSSVEVPDSDSRPSSGFYELSDVGSCSLSTSCASVC 142 thirteen-lined ...
XP_006011471  73 EQRLEATLAALKEQLFRLKRQDIGLKSHLQQLDQQISELKLDVNKVSTEHLESDSRPSSGFYELSDGGSCSLSNSCTSVY 152 coelacanth
XP_007238563 156 SECLsSSSQASLLPLSSLPsaphavllpAQAEVSRRRSADestaqpdaprgpgvrlgssg-----irttsvsserarqrp 230
XP_007484975 176 SESI-SSSHSSLLPGIQTPkv------rlSIFDYRPKSADettvhsahlqpqripvsegcwikgspesegetlakfkprp 248
NP_001100934 138 SDRL-SPSLGSWLPVLQPSks------rsGMGDWRPRSADettvpawspqrtedsrllhg-----aedtgrlrgmfrprp 205
XP_003792465 145 SDCV-SPSLVSLLPAAQPPkp------rpCMGDWRPRSADeisvpawrpeatedgsrplss----aggtglpqgmfrprp 213
XP_001083736 148 SDHI-SPSLGSLLPMAQAPka------rpSMGDWRPRSVDettvpawrpqateegtrprgs----menagqpwgtfwprp 216
XP_006638824 162 SECL-SSSQSSLLPSCQHSpp-----------gtRPQSADeitvqgsasqrggvrmgsrir---tstdppasstrarprp 226
2_pfamImport 133 SECL-SSSQTS-LLHPSSPansq-vtppSRVDGCRRRSADesssqphppratglhlgssr-----irantagaehkrprp 204
XP_017827047 148 SDRI-SPSLGSLLPVAQAPka------rpSMGDWRPRSVDetavpawrpqateegaklpds----lreagqpsgtfwsrp 216 white-tufted-ea...
XP_005321496 143 SDRL-SPSLGSLLPAV--Smv------rpNMGDWRPRSADettvpawrpqpikesgrllds----ggdpgqprgmfrprp 209 thirteen-lined ...
XP_006011471 153 SECM-SSSLNSIPPHSQQPrs------kvSLLEYRPRSADettvrtaniqqqgiyrrlacqi-rtsadvpgnhakfrqrp 224 coelacanth
XP_007238563 231 vstgdLDRVINPGFGYCKPV-DMKTSAVCRnlc---npTLDTKFQSNLVSRNGMEVYRYPSPLHAVALQSPIFSLSGDQE 306
XP_007484975 249 vstgdLERIVPADGGLQKTItDPKSVSPLChgteilfhVVDPKYQSDLVSKSGNDIYPYPSPLHAVALQSPLFSLTRET- 327
NP_001100934 206 vstgdLERVLPADTGLQNAGtDASS--LLCqgieipahALDPKYQRDLVARGGQEVYPYPSPLHAVALQSPLFALPKEA- 282
XP_003792465 214 vstgdLDRAQPADTGLQSASaDPQTPSILSqgtdapphMLDPQYQRDLVSQGGREVYPYPSPLHAVALQSPLFALAKES- 292
XP_001083736 217 vstgdLDRALLADTGLQKASaDAELLGLLCqgvdiplhMPDPKYRQDLVSQGGREMYPYPSPLHAVALQSPLFALAKET- 295
XP_006638824 227 vstgdLDRMVLPGLGFYKAP-DTKAVPSLShginikqtAIDPRYQSNLVSRNGSDVYQYPSPLHAVALQSPIFSLSGET- 304
2_pfamImport 205 vstgdLDAVLAQGVSYFKPM-DPRKPLLGPslk---tsKVDPKFQSNLVSRTGAEVYPYPSPLHAVALQSPIFSVGGDPT 280
XP_017827047 217 vstgdLDRALTADMGLQKAGpDPELLRLLCqgadtplhMLDPKYRQDLVSQGGREVYPYPSPLHAVALQSPLFALTKET- 295 white-tufted-ea...
XP_005321496 210 vstgdLERVLPVDLGLRRVDqEATSPSHLCqgmdvpspKLDPKYQRDLVSRGGREVYLYPSPLHAVALQSPLFALTQET- 288 thirteen-lined ...
XP_006011471 225 vstgdLERMALPGAGFQKFS-NLKSVLSLYngsdlqirTVDPKYQSDLVSKNGGDIYLYPSPLHAVALQSPLFCLA-EDS 302 coelacanth
XP_007238563 307 TPAGSEAQENPVEVGLmedtlsKQDLSASRPV----------GYIVKLVQRSSGKMNLQRELSTEKLYTSCSDTqgpgli 376
XP_007484975 328 --LETNNHLPLSKPSLnmsgpsLIR----TKPivev--pppgGYIDKLLQLTRDRGKYTGGSVS-ERGSVKGSL------ 392
NP_001100934 283 --PCFDIYSPPEEPPLvpadqnGTQPEPEPEPtrel--gsaeAYIHRLLRLRGQELPLREVGQE---------------- 342
XP_003792465 293 --PQGDGPPPLRKSIQgpenlcTVQ----TGLvlea--aparAYIDRLLSLRSHGTPTRSSVGE---------------- 348
XP_001083736 296 --PQSGGPSYPRKTPLgpaglnTIQ----TGPvleagpararAYIDRLLHLWGRETPAKGSGGE---------------- 353
XP_006638824 305 --ATAQGSQTDTVAGAtvsscvSSKTSFESRPd---------GYIYKLLQHKKNRETLQPEGCCQ--------------- 358
2_pfamImport 281 IPGLLEGQGPGTGSsda---rqRAQMGYETLTq---------TYIDRLLVRSLNKASSNIGPEDVQTHSDCQKNlaevvp 348
XP_017827047 296 --LQGGGPSSPRKAPLgpaavsTVQ----TRLvleagpararAYIDRLLCLWGRETPAKGSEGE---------------- 353 white-tufted-ea...
XP_005321496 289 --PPLDSRLPPRSPLLgardlsTTP----ARPvlea--gpagAYIDRLLRLRSQEAASRGPGGE---------------- 344 thirteen-lined ...
XP_006011471 303 SNTENNHLMSDTGRPNtaskliVATPLFETRPs---------GYINKLLQLNKCKvnkqpdvnirg-------------- 359 coelacanth
XP_007238563 377 gsraqvgnygpvtvaevqgglQQKTLYLENPVDsGKYSPARTSGQEQMISCPQ---MISDGFEESKPVCQFRC-PtgAMN 452
XP_007484975 393 ---------------------PPSQQRLSITSGiSGLRGNSDSQLEKQVSSPEsrqAKVGRSQREVP-----DaNsmKLQ 446
NP_001100934 343 ---------------------QGG---DAAAFPqKSCGQRSDGMGQLEKPACG---ADWGGMKPSRG-----AaKdsLRQ 390
XP_003792465 349 ---------------------QSPLRREVSPSRqEQGDQRMDNEGQLQKSVLGpgrG---------------AsGgfPQQ 392
XP_001083736 354 ---------------------QGPLRHAASPSPqRQGGWSTDGGGRL--LVFApgrEDEGGPAQSRGa------GrgPQQ 404
XP_006638824 359 ---------------------VDRAQPLLSCHNgVFSLSTAVTKVNCRAMLKSqgdQSLSQ-----------GqPniKQQ 406
2_pfamImport 349 ----------------vipvvPQRDKSAVQPHSvQTTS-SVLDNSQRRFCMPYahhESAENANVKQPMKAPEpsf----- 406
XP_017827047 354 ---------------------QGPRRCAASPSPqKQGGWSADGGDQLKKLVFApgrEDEGGPAQRRG-----AsRcgPQQ 407 white-tufted-ea...
XP_005321496 345 ---------------------QGPPGHEASPSPkKPDAQRLDSGGQPAKLVCSpgrGDLGVAAQSRA-----SsRdgLGQ 398 thirteen-lined ...
XP_006011471 360 ----------feknqptvtlqKDTPIQNIGPVKiNNDRQSSMQNESTrn------sRDVGKIPAVPA-----KnEkaKQQ 418 coelacanth
XP_007238563 453 HRPGVLmgpt-----fkvREKTEDQKQSTLFHHNknnkDDF------------------------------KATATVSKP 497
XP_007484975 447 EAREACld--------teQPASQQSLESMATNTSfp-eEVSpasavqee---------------pggiglkQDTASCSQM 502
NP_001100934 391 QGPVSLvg--------teTLSSPLKEETIPWNPCvrgdNTV-------------------------------SSSPASQI 431
XP_003792465 393 QGPTPPvgaqqvvskwpgHPSGLPEEEPRPLNHCvlgeTPV-------------------------------STPPCSKP 441
XP_001083736 405 QGSMPLeg--------pqHPGNLPEEGSKPSNSCvlreTMA-------------------------------WPSPSLKA 445
XP_006638824 407 EVKTVs-----------eEKVAIVNYRQETVNCAqtakVFHhredlkachspldadqrvsvlveankcperVQKGEGNSC 475
2_pfamImport 407 ---------------rysYPAMSTDCT-EGATISslgkKDKpkgefasv--------------lksnsenqCVDKPESRP 456
XP_017827047 408 QGPVSLeg--------pqHPGSLPEEGSQPSNHCilreTVA-------------------------------GPSPSSQA 448 white-tufted-ea...
XP_005321496 399 QEPAPLlh--------tqSPRHPREKGPEPWNLCafgeTSV-------------------------------GPSPCPQA 439 thirteen-lined ...
XP_006011471 419 GANYlg----------nsTPSSNFREEQKITSDCcplkSNArglasve------------------dvrnytGKSSGPHL 470 coelacanth
XP_007238563 498 SES------------RLSLISSSNDENRSSDGShqrtgqsEFVHAQFVPAGSQRVKV----------------------- 542
XP_007484975 503 YQShln-------maPQRSNAKVILPPRKVGKKgtslvtgEFVHAQFVPGEAHLMRL----------------------- 552
NP_001100934 432 QQPy-----------TDCGQGPVLSPSRVLGPEspplapvPFAYTSSTTNETSPLRL----------------------- 477
XP_003792465 442 WQPps---------aDSCGQGRVVSPSRRVDQScp------qASGAFPARKAPSTRL----------------------- 483
XP_001083736 446 QQTpp---------aQDCGRGNVISPSRMLDKSpsp-asgHFAHPSFAAS------L----------------------- 486
XP_006638824 476 PDHscvdtlceaalsRKALNRKHSSTSSLEKKShealpqsEFVHAKFVPAGSLQVKV----------------------- 532
2_pfamImport 457 QDRsgq------kqkMAMGHSSSTEas------------pDFVHAEFVPAGSQRVKV----------------------- 495
XP_017827047 449 QSTpp---------aQDCGRDNMLP-SRRLDESppp-ssgYFTHLPFAASRPSPPWP----------------------- 494 white-tufted-ea...
XP_005321496 440 QQPhg--------drSPGISSSSGS----VDCGspprapgHLVHPPCTASEASRMGL----------------------- 484 thirteen-lined ...
XP_006011471 471 qs------------yLSGTQLDILLPSTALPTKls-------------kKQTRTGSVrrvrevlsktefvhakfvpaesh 525 coelacanth
XP_007238563 543 ----HQDEKKTKAVKlrkRGNEK-PPG-KKHQQRHSLRELEK----------DRGCHVKIRGETRDTKQISGRl------ 600
XP_007484975 553 ----KGSNPKAKAMKakrRNSDKvLRL---GKQQPLLAERPR----------GMHVASRLPAEWNPSPRFHGGknlvrr- 614
NP_001100934 478 ----RMGSPQNKAMKvkrRVSEKvPRL---GKQLPPQPEKQR----------GIHAA--WSTELDPSSRPPQGglnrr-- 536
XP_003792465 484 ----DTGQLKAKVAKvkrRSSDRaLRF---GKQMPPAPDRHL----------GVHSAPWLPPEWAPSPWTQETsglrr-- 544
XP_001083736 487 ----KMGPPKSKAEKikrRPTDKvLRF---ARQPPLLLERPE----------GAHAAPQPSLEWDPAHWSPGRgglprr- 548
XP_006638824 533 ----RQAGKKTKAVKlkrRSSEK-LRTvKQ-----LPCENLK----------IPLVSGGLSAETAPFNKHSGGravyke- 591
2_pfamImport 496 ----RQADRKTKAVKlrrKISEK-PRA-MRQQHGYSSGEKAR----------EA----SGGSKGEQRRSGKGKvtqkft- 554
XP_017827047 495 ----KMGPPKSKTEKikrRLTDKvLRF---AGQPSIRLQRPE----------GTQAAPQLSLEWDPAHWPLGRgvlqrr- 556 white-tufted-ea...
XP_005321496 485 ----KTGHPKTKPVKvrrKASDKmPRL---GNQAPLLPERPWgvhaapqrspEC----------GPTHRPQEGglrrr-- 545 thirteen-lined ...
XP_006011471 526 qikiRQAGSKTKAVKlrrRNSEK-GRT-----MKPLPCEKPR----------EISNSTRLTAQ-----RVHPSkssagkg 584 coelacanth
XP_007238563 601 --------rEARVRSCSESSLLGPGNPCAssstttnAHLqssqpqqrsskprktsqvpdLGNssSVCQSRRKPNSRKWPS 672
XP_007484975 615 ----ptfvgEVTGRSCSESSLFPVQFLTPkvvsrpeLYPasahpl--------ysfeaaQLNl-VASGGARKKQ-RKWQS 680
NP_001100934 537 ----ptlarEPPGRSCSESTLYPVPLLVPlvvtqreSYPassqal-------------fpmetaLLSSAARRKQ-RRWQS 598
XP_003792465 545 ----saparEAPGRSCSESTLYPAPFLLPllvaprqGCGaapali--------------plgavPVSRVARRRQ-RQWQS 605
XP_001083736 549 ----ptlawEAPGRSCSESTLYPMPVLVPvavapqeGHQtsaqal-------------fpfeaaLLTSVARRKH-RRWQS 610
XP_006638824 592 ----hncvgEVAGRSCSQSSLYPA--HLRqtqqvpkFGPstthrll------------lpeprvSVDTSKKRQT-RKWQS 652
2_pfamImport 555 ----acpseEQRQGSGSESSHSSPG-LVYthkvhpkPHPipavtkask---nrrppsldHAQ--ASEHRKKRQGG----S 620
XP_017827047 557 ----palawECLGAPLPSLPSTPCPSSSPcgg-paeSQRtsahal-------------fpleatLLTSVARRKH-GRWQS 617 white-tufted-ea...
XP_005321496 546 ----pglagVAPGRSCSESTLYPVPFFVPllvaqreSYRapsqal-------------ssletaPLCAAARRKQ-RRWQS 607 thirteen-lined ...
XP_006011471 585 lirrptyagETEGRSCSESTLYFMEYRQPqytdrpePHKtsvnrl--------------qsseaACAGITKKKQ-RKWQS 649 coelacanth
XP_007238563 673 ASEIQLPPHPlqthhqrsrea-pthrlaglcpQKPgMRPhsghwggvphpiqppfssssssyfnnmnlRY-------PPA 744
XP_007484975 681 TVEISAKTHLtsfstdpslalprppgrragilRTVsSRS-----------------------------RS-------KIP 724
NP_001100934 599 TMEISAKSRSvsrpgpnlgpp-kspakrtggpR---AQS-----------------------------RP-------SLA 638
XP_003792465 606 SVEISARAHPahclepspgip-gpsawragstR---AWG-----------------------------RP-------TQA 645
XP_001083736 611 TMEISARARLascpesnlgpp-rpvarraggpQ---ARG-----------------------------RP-------LLV 650
XP_006638824 653 VVEISTKPSLapfpnsrptgh-lqvlrkagmmRSTsLRHrpsq---------------------ygvpRH-------PHP 703
2_pfamImport 621 DVEMFQGSSFqhyrskgpq-----apgsmhmvRs--VKSgqwvapprsfqih----vpshsflhnlnaRY-------PPA 682
XP_017827047 618 TVDISARARMagypesnlgps-rpmarrvggpQ---ARG-----------------------------RP-------TLI 657 white-tufted-ea...
XP_005321496 608 TMEISAEAHLasaqepslgps-rsparragglQ---AQG-----------------------------RP-------TLA 647 thirteen-lined ...
XP_006011471 650 AVEISVKAHQpsfpssvrpgfm----------------------------------hpkqhvrkasvlRTvslkthqAHY 695 coelacanth
XP_007238563 745 P--ACTRYPPRCeSEfSEYSAECASLFHSTIAESSEGE-LSDFTANRFGDSESSQGSRTASd--SDSSLSLDEEDIleee 819
XP_007484975 725 ShnTY----AKSeSDhSEYSAECASLFHSTIVETSEDD-VSDYTANCFGDSESGDSDSDGAcrsSESSLTLDYEEAv--- 796
NP_001100934 639 RqdAC----ARSeSDpSEHSAECASLFHSTIAETSEDEeASDHTANRFGD-ESSSNDSEDCaqsSRRGLAIGSAEAa--- 710
XP_003792465 646 RedTC----TRSeSDpSEQSVDCASPPHSTVAETSGDE-ASDHTVNCFGDRESSGSDSEGGvqsRGRSSALDRGVSr--- 717
XP_001083736 651 RqdAQ----TRSnSEpSKHSAECDPRFPSVIPETSEGE-SSDHTTNRFGDHESSSSDEEGSaqsRDCDLALGYVAAg--- 722
XP_006638824 704 NsySC----LLSeSEvSEYSAECASLFHSTIAESSEGE-LSDFTANRFGDSESSESSSDGS---SDSSLSLNSEDMe--- 772
2_pfamImport 683 PfhMSNHYPPRCe---SEYSAECASLFHSTIAESSEGE-MSDNTTNRFGDSESSQSFQSFSd--SDSSLSIDEDDQvdsr 756
XP_017827047 658 RqdAH----TRSdSEpSKHSAECDLRFPSVIPETSEGE-ASEHTTSRFADHESGSSDGEGSaqsRDCGLALGHTAAg--- 729 white-tufted-ea...
XP_005321496 648 RqdAC----SRSqSDsAECSAECASLLQSTIAESSEEA-ASDHTANRFGDGESSSSDSEDCfqsHSRRLGVDVAAAr--- 719 thirteen-lined ...
XP_006011471 696 RhsAYIRSSARSdSDqSEYSAECASLFHSTIVETSEDE-RSDYTTNRFGDSESSESDSDAT---SDSSLTLDYDDTd--- 768 coelacanth
XP_007238563 820 edeGDLVWAEAAV----GPTAAGLSLQNQHpPRPEPVACRIKASRALKKKIRRFQPASLKVMTLV 880
XP_007484975 797 --gSELIWPKAIV----QQPVKGQAASKPS-HHPVPKICRIKASKALKKKIRRFQPASLKVMTMV 854
NP_001100934 711 --qGGWAWPPVPLqqvsRAPGGTRPSLPPV-----PKLCRIKASKALKKKIRRFQPAALKVMTMV 768
XP_003792465 718 --rGQRARLQM------GPPVGSRPPLPPV-----PKLSRVKASRALKRRIRRFQPSSLKVITLV 769
XP_001083736 723 --hTELTWTQEVP-------VSSGPLLSPV-----PKLCRIKASKALKKKIRRFQPTALKVMTMV 773
XP_006638824 773 --dGELVWAQSTV----GPTAAGLPLS----SRPEPPACRIKASKALKKKIRRFQPAALKVMTMV 827
2_pfamImport 757 gedRDLVWAEAAL----GPAAAG--LRQL--PRPEPSACRIKASRALKKKIRRFQPASLKVMTLV 813
XP_017827047 730 --hVELAWPQAAP-------VSSRPLLSPV-----PKLCRIKASKALKKKIRRFQPTSLKVMTMV 780 white-tufted-ear marmoset
XP_005321496 720 --rGELAWPQAVPqqppRAPVGARPPLPPV-----PKLCRIKASRALKKKIRRFQPAALKVMTMV 777 thirteen-lined ground squirrel
XP_006011471 769 --aSEFVWPEASSqpaaSSQPAAASVAPSKqAHTEPKLCRIKASKALKKKIRKFQPASLKVMTMV 831 coelacanth
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