Conserved Protein Domain Family
Xrn1_D3
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pfam18194: Xrn1_D3 
Exoribonuclease 1 Domain-3
This domain is found in 5' to 3' exoribonuclease 1 (XRN1) present in Kluyveromyces lactis. XRN1 is involved in transcription, RNA metabolism, and RNA interference. This domain, known as D3, is the third of four domains located far from the active site. These four domains may help to stabilize the N-terminal segment of Xrn1 for catalysis.
Links
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Statistics
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PSSM-Id: 465674
Aligned: 114 rows
Threshold Bit Score: 64.0406
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
KND00627     1078 ASSKLNEIKEWLKEAgVKDFERVSLDTRALTKNVIKDIEER-VDEVYKRIgdVKIKAVTVKNVPRPAVLKPAHA 1150
SMN18519     1139 SVKILDQVKAWLKHV-TENFVTVSLESDSLTKASIAEVENYiIANVAAIE--QQSETKQLAKVPRDAVLNPRDS 1209
XP_003956435 1093 AMKKLQEIKDWLKFS-EENFVIVSNESDSLTKGSIRAVEDF-IEVHSSGR--ENSETKQLTKVPRDAILNPRVS 1162
CCK71177     1095 AMERLDEIKKWNKFV-TENFVIVSLESDSLTKGSIVAVEKY-VLQHSSEL--AQFEMKNLAKVPREAILNPRVS 1164
XP_003675771 1091 A-KFLDEIKKWLKFV-TEKFVVVSIESDSLTKSSIGIVEEF-VQEYTRKS--YPTEKKQLANVPRQAILNPRTS 1159
CCD26129     1090 TSKMLDQIKAWVKFA-TEKFVVVSIESDSLTKSSIIAVEEV-IQHYSMLP--LHPEKKQLANVPRQAILSPRSS 1159
EJT44395     1087 AMNSLDGVKQWLKYV-SSKFIAVSLESDSLTKTSIAAVEEH-IMKYAANI--GGHERKQLAKVPRKAVLNPRSS 1156
XP_003648470 1085 ATKILEAVAAYVGDL-RSQFIMVSLESDSLTKASIHAVETE-IQRFVQLE--DRTEKRQLAKVPREAVLDPNRS 1154
Q75AG4       1086 ASAMLASITAFIKDA-RQSFVIVPLESDSLTKASIQAVEKE-IMRIADLP--DQSEKRQLAKVPREAILDPRQS 1155 Eremothecium gossypii
OEJ83867     1090 TKELVSSVKKWLSDV-KADFVTVQNESDALSKSAISQIEDYaIKHVATEK--LNTETKKLSKVPTDAILVPQQS 1160
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