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Conserved domains on  [gi|3319006|pdb|1A7B|B]
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Chain B, CD2

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 10146415)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 2-96 6.97e-27

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


:

Pssm-ID: 409431  Cd Length: 98  Bit Score: 94.34  E-value: 6.97e-27
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1A7B_B       2 DSGTVWGALGHGINLNIPNFQmtDDIDEVRWERGSTLVAEFK--RKPFL---KSGAFEILAN-GDLKIKNLTRDDSGTYN 75
Cdd:cd05775  1 SSGEVYGALGGNVTLTISSLQ--DDIDEIKWKKTKDKIVEWEnnIGPTYfgsFKDRVLLDKEsGSLTIKNLTKEDSGTYE 78

                       90       100
               ....*....|....*....|.
1A7B_B      76 VTVYSTNGtRILDKALDLRIL 96
Cdd:cd05775 79 LEITSTNG-KVLSSKFTLEVL 98
 
Name Accession Description Interval E-value
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 2-96 6.97e-27

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 94.34  E-value: 6.97e-27
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1A7B_B       2 DSGTVWGALGHGINLNIPNFQmtDDIDEVRWERGSTLVAEFK--RKPFL---KSGAFEILAN-GDLKIKNLTRDDSGTYN 75
Cdd:cd05775  1 SSGEVYGALGGNVTLTISSLQ--DDIDEIKWKKTKDKIVEWEnnIGPTYfgsFKDRVLLDKEsGSLTIKNLTKEDSGTYE 78

                       90       100
               ....*....|....*....|.
1A7B_B      76 VTVYSTNGtRILDKALDLRIL 96
Cdd:cd05775 79 LEITSTNG-KVLSSKFTLEVL 98
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 3-96 6.22e-13

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 59.39  E-value: 6.22e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1A7B_B          3 SGTVWGALGHGINLNIP-NFQMTDDIDEVRWERG------STLVAEFKRK--PFLKSGAFEILA-----NGDLKIKNLTR 68
Cdd:pfam07686   3 PREVTVALGGSVTLPCTySSSMSEASTSVYWYRQppgkgpTFLIAYYSNGseEGVKKGRFSGRGdpsngDGSLTIQNLTL 82

                          90       100
                  ....*....|....*....|....*...
1A7B_B         69 DDSGTYNVTVYsTNGTRILDKALDLRIL 96
Cdd:pfam07686  83 SDSGTYTCAVI-PSGEGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 29-84 4.90e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 33.25  E-value: 4.90e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
1A7B_B         29 EVRWERGstlvaefKRKPFLKSGAFEILANGD---LKIKNLTRDDSGTYNVTVYSTNGT 84
Cdd:smart00410 25 EVTWYKQ-------GGKLLAESGRFSVSRSGStstLTISNVTPEDSGTYTCAATNSSGS 76
 
Name Accession Description Interval E-value
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 2-96 6.97e-27

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 94.34  E-value: 6.97e-27
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1A7B_B       2 DSGTVWGALGHGINLNIPNFQmtDDIDEVRWERGSTLVAEFK--RKPFL---KSGAFEILAN-GDLKIKNLTRDDSGTYN 75
Cdd:cd05775  1 SSGEVYGALGGNVTLTISSLQ--DDIDEIKWKKTKDKIVEWEnnIGPTYfgsFKDRVLLDKEsGSLTIKNLTKEDSGTYE 78

                       90       100
               ....*....|....*....|.
1A7B_B      76 VTVYSTNGtRILDKALDLRIL 96
Cdd:cd05775 79 LEITSTNG-KVLSSKFTLEVL 98
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 3-96 6.22e-13

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 59.39  E-value: 6.22e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1A7B_B          3 SGTVWGALGHGINLNIP-NFQMTDDIDEVRWERG------STLVAEFKRK--PFLKSGAFEILA-----NGDLKIKNLTR 68
Cdd:pfam07686   3 PREVTVALGGSVTLPCTySSSMSEASTSVYWYRQppgkgpTFLIAYYSNGseEGVKKGRFSGRGdpsngDGSLTIQNLTL 82

                          90       100
                  ....*....|....*....|....*...
1A7B_B         69 DDSGTYNVTVYsTNGTRILDKALDLRIL 96
Cdd:pfam07686  83 SDSGTYTCAVI-PSGEGVFGKGTRLTVL 109
Ig5_Contactin cd04969
Fifth immunoglobulin (Ig) domain of contactin; The members here are composed of the fifth ...
 30-82 1.64e-03

Fifth immunoglobulin (Ig) domain of contactin; The members here are composed of the fifth immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma.


Pssm-ID: 409358 [Multi-domain]  Cd Length: 89  Bit Score: 34.36  E-value: 1.64e-03
                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|...
1A7B_B      30 VRWERGSTLVAEFKRkpflksgaFEILANGDLKIKNLTRDDSGTYnvTVYSTN 82
Cdd:cd04969 34 ISWSKGTELLTNSSR--------ICILPDGSLKIKNVTKSDEGKY--TCFAVN 76
IgI_2_MuSK cd20968
agrin-responsive second immunoglobulin-like domains (Ig2) of the Muscle-specific kinase (MuSK) ...
 18-84 2.54e-03

agrin-responsive second immunoglobulin-like domains (Ig2) of the Muscle-specific kinase (MuSK) ectodomain; a member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin-like (Ig) domains of the Muscle-specific kinase (MuSK) ectodomain. MuSK is a receptor tyrosine kinase specifically expressed in skeletal muscle, where it plays a central role in the formation and maintenance of the neuromuscular junction (NMJ). MuSK is activated by agrin, a neuron-derived heparan sulfate proteoglycan. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the MuSK lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409560 [Multi-domain]  Cd Length: 88  Bit Score: 34.14  E-value: 2.54e-03
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....*..
1A7B_B      18 IPNFQMTDDIDEVRWERGSTLVAEFKRkpflksgaFEILANGDLKIKNLTRDDSGTYNVTVYSTNGT 84
Cdd:cd20968 19 LPCTTMGNPKPSVSWIKGDDLIKENNR--------IAVLESGSLRIHNVQKEDAGQYRCVAKNSLGI 77
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 29-74 3.34e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 33.46  E-value: 3.34e-03
                       10        20        30        40
               ....*....|....*....|....*....|....*....|....*.
1A7B_B      29 EVRWERGSTLVAEFKRKPFlksgaFEILANGDLKIKNLTRDDSGTY 74
Cdd:cd00096 14 TITWYKNGKPLPPSSRDSR-----RSELGNGTLTISNVTLEDSGTY 54
IgV_CEACAM_like cd05741
Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...
 6-85 4.38e-03

Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and related domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface. This family corresponds to the D1 Ig-like domain. Also belonging to this group is the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84-like family. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. SLAM family proteins are organized as an extracellular domain with having two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409403  Cd Length: 102  Bit Score: 33.65  E-value: 4.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1A7B_B        6 VWGALGHGINLNIPNFQMTDDidEVRWERGSTL-----VAEFKRK---PFLK---SGAFEILANGDLKIKNLTRDDSGTY 74
Cdd:cd05741   5 FYGAEGKNVLLLVPNLQTPLK--SVSWYKGKQVsrndeIAEYENSsdeFRAGsafSGREYIYTNGSLLIQNITLSDTGFY 82

                        90
                ....*....|.
1A7B_B       75 NVTVYSTNGTR 85
Cdd:cd05741  83 TLESTNIGGKT 93
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 29-84 4.90e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 33.25  E-value: 4.90e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
1A7B_B         29 EVRWERGstlvaefKRKPFLKSGAFEILANGD---LKIKNLTRDDSGTYNVTVYSTNGT 84
Cdd:smart00410 25 EVTWYKQ-------GGKLLAESGRFSVSRSGStstLTISNVTPEDSGTYTCAATNSSGS 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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