NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|157830968|pdb|1EMN|A]
View 

Chain A, FIBRILLIN

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 10640301)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

CATH:  2.10.25.10
Gene Ontology:  GO:0005515|GO:0005509
PubMed:  3282918|2288911|7606779

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
4-34 1.05e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.05e-05
                          10        20        30
                  ....*....|....*....|....*....|..
1EMN_A          4 DMDECKEPDVCKHG-QCINTDGSYRCECPFGY 34
Cdd:smart00179  1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
43-77 1.10e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.10e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
1EMN_A         43 DTDECSVGNPCGNG-TCKNVIGGFECTCEEGFEPGP 77
Cdd:smart00179  1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGR 36
 
Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
4-34 1.05e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.05e-05
                          10        20        30
                  ....*....|....*....|....*....|..
1EMN_A          4 DMDECKEPDVCKHG-QCINTDGSYRCECPFGY 34
Cdd:smart00179  1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
43-77 1.10e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.10e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
1EMN_A         43 DTDECSVGNPCGNG-TCKNVIGGFECTCEEGFEPGP 77
Cdd:smart00179  1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGR 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4-36 1.80e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.80e-05
                       10        20        30
               ....*....|....*....|....*....|....
1EMN_A       4 DMDECKEPDVCK-HGQCINTDGSYRCECPFGYIL 36
Cdd:cd00054  1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 43-74 6.69e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.69e-05
                       10        20        30
               ....*....|....*....|....*....|...
1EMN_A      43 DTDECSVGNPCGN-GTCKNVIGGFECTCEEGFE 74
Cdd:cd00054  1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
 
Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
4-34 1.05e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.05e-05
                          10        20        30
                  ....*....|....*....|....*....|..
1EMN_A          4 DMDECKEPDVCKHG-QCINTDGSYRCECPFGY 34
Cdd:smart00179  1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
43-77 1.10e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.10e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
1EMN_A         43 DTDECSVGNPCGNG-TCKNVIGGFECTCEEGFEPGP 77
Cdd:smart00179  1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGR 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4-36 1.80e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.80e-05
                       10        20        30
               ....*....|....*....|....*....|....
1EMN_A       4 DMDECKEPDVCK-HGQCINTDGSYRCECPFGYIL 36
Cdd:cd00054  1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 43-74 6.69e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.69e-05
                       10        20        30
               ....*....|....*....|....*....|...
1EMN_A      43 DTDECSVGNPCGN-GTCKNVIGGFECTCEEGFE 74
Cdd:cd00054  1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF smart00181
Epidermal growth factor-like domain;
7-39 4.05e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 34.41  E-value: 4.05e-04
                          10        20        30
                  ....*....|....*....|....*....|...
1EMN_A          7 ECKEPDVCKHGQCINTDGSYRCECPFGYILAGN 39
Cdd:smart00181  1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
EGF smart00181
Epidermal growth factor-like domain;
46-74 1.25e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 33.26  E-value: 1.25e-03
                          10        20
                  ....*....|....*....|....*....
1EMN_A         46 ECSVGNPCGNGTCKNVIGGFECTCEEGFE 74
Cdd:smart00181  1 ECASGGPCSNGTCINTPGSYTCSCPPGYT 29
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 3-40 7.68e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 33.13  E-value: 7.68e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
1EMN_A        3 VDMDECKE-PDVCKHGqCINTDGSYRCECPFGYILAGNE 40
Cdd:cd01475 185 VVPDLCATlSHVCQQV-CISTPGSYLCACTEGYALLEDN 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH