|
Name |
Accession |
Description |
Interval |
E-value |
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
8-818 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 1201.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 8 PNFPKLEEEVLAFWKREKIFQKSVENRKGGPRYTVYEGPPTANGLPHVGHAQARSYKDLFPRYKTMRGYYAPRRAGWDTH 87
Cdd:COG0060 16 ANLPKREPEILKFWEENDIYEKSREARAGRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDCH 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 88 GLPVELEVEKKLGlKSKREIEAYGIERFNQACRESVFTYEKEWEAFTERIAYWVDLEDAYATLEPTYIESIWWSLKNLFD 167
Cdd:COG0060 96 GLPIELKVEKELG-IKKKDIEKVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPEYEESIWWALKKLYE 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 168 RGLLYRDHKVVPYCPRCGTPLSSHEValGYKEIQDPSVYVRFPLKEPKKL-GLEKASLLIWTTTPWTLPGNVAAAVHPEY 246
Cdd:COG0060 175 KGLLYKGLKPVPWCPRCGTALAEAEV--EYKDVTSPSIYVKFPVKDEKALlLLEDAYLVIWTTTPWTLPANLAVAVHPDI 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 247 TYAAFQV-GDEALILEEGLGRKLLG----EGTQVLKTFPGKALEGLPYTPPYP--QALEKGYFVVLADYVSQEDGTGIVH 319
Cdd:COG0060 253 DYVLVEVtGGERLILAEALVEAVLKelgiEDYEVLATFKGAELEGLRYEHPFYyvVGYDRAHPVILGDYVTTEDGTGIVH 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 320 QAPAFGAEDLETARVYGLPLLKTVDEEGKLL--VEPFKGLYFREANRAILRDLRGRGLLFKEESYLHSYPHCWRCSTPLM 397
Cdd:COG0060 333 TAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTeeAPLFAGLFVKDANPAIIEDLKERGALLAREKITHSYPHCWRCKTPLI 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 398 YYATESWFIKNTLFKDELIRNNQEIHWVPPHiKEGRYGEWLKNLVDWALSRNRYWGTPLPIWVCQACGK----EEAIGSF 473
Cdd:COG0060 413 YRATPQWFISMDKLRDRALEAIEKVNWIPEW-GEGRFGNMLENRPDWCISRQRYWGVPIPIWVCEDCGElhrtEEVIGSV 491
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 474 QELKARATKPLPEPFDPHRPYVDQVELACACGGTMRRVPYVIDVWYDSGAMPFASLhypfEHEEvfRESFPADFIAEGID 553
Cdd:COG0060 492 AELLEEEGADAWFELDLHRPFLDETLKCPKCGGTMRRVPDVLDVWFDSGSMHFAVL----ENRE--ELHFPADFYLEGSD 565
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 554 QTRGWFNSLHQLGVMLFGSIAFKNVICHGLILDEKGQKMSKSKGNVVDPWDIIRKFGADALRWYIYvSAPPEADRRFGPN 633
Cdd:COG0060 566 QTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKYGADILRLWVA-SSDYWGDLRFSDE 644
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 634 LVREtVRDYFLTLWNVYSFFVtyANLDRPD-LKNPPPPEKRPEMDRWLLARMQDLIQRVTEALEAYDPTTSARALRDFVV 712
Cdd:COG0060 645 ILKE-VRDVYRRLRNTYRFLL--ANLDDFDpAEDAVPYEDLPELDRWILSRLNELIKEVTEAYDNYDFHRAYRALHNFCV 721
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 713 EDLSQWYVRRNRRRFWKNE-DALDREAAYATLYEALVLVATLAAPFTPFLAEVLWQNLVRsvrlEAKESVHLADWPEADP 791
Cdd:COG0060 722 EDLSNWYLDISKDRLYTEAaDSLDRRAAQTTLYEVLETLVRLLAPILPFTAEEIWQNLPG----EAEESVHLADWPEVDE 797
|
810 820 830
....*....|....*....|....*....|.
1JZQ_A 792 ALADEALVAQMRAVLKVVDLAR----AARAK 818
Cdd:COG0060 798 ELIDEELEAKWDLVREVRSAVLkaleAARKE 828
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
8-816 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 1005.75 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 8 PNFPKLEEEVLAFWKREKIFQKSVENRKGGPRYTVYEGPPTANGLPHVGHAQARSYKDLFPRYKTMRGYYAPRRAGWDTH 87
Cdd:TIGR00392 6 GNLSKREEKILAFWQENDIFEKVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPGWDTH 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 88 GLPVELEVEKKLGLKSKREIEAYGIERFNQACRESVFTYEKEWEAFTERIAYWVDLEDAYATLEPTYIESIWWSLKNLFD 167
Cdd:TIGR00392 86 GLPIEHKVEKKLGISGKKEISSLEIEEFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFKEAHE 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 168 RGLLYRDHKVVPYCPRCGTPLSSHEVAL--GYKEIQDPSVYVRFPLKEPKKLGLEK--ASLLIWTTTPWTLPGNVAAAVH 243
Cdd:TIGR00392 166 KGLLYRGLKPVYWSPRCRTALAEAEVEYkeNYKDVKDPSIYVKFPVKKDKKTYLKVklSSLLIWTTTPWTLPSNLAIAVH 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 244 PEYTYAAFQVG--DEALILEEGLGRKL---LGEGTQVLKTFPGKALEGLPYTPPYP----QALEKGYFVVLADYVSQEDG 314
Cdd:TIGR00392 246 PDFEYALVQDNtkVEYFILAKKLVEKLynkAGSDYEIIKTFKGSDLEGLEYEHPLYdfvsQLKEGAPVVIGGDHVTTEDG 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 315 TGIVHQAPAFGAEDLETARVYGLPLLKTVDEEGK--LLVEPFKGLYFR-------EANRAILRDLRGRGLLFKEESYLHS 385
Cdd:TIGR00392 326 TGIVHTAPGHGEEDYEIGKKYGLEVLSPVDEKGVytEGVNDFQGRFVKdadkdiiKANKIIIEQLKDKGLLLKAEKITHS 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 386 YPHCWRCSTPLMYYATESWFIKNTLFKDELIRNNQEIHWVPPHIkEGRYGEWLKNLVDWALSRNRYWGTPLPIWVCQACG 465
Cdd:TIGR00392 406 YPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWG-EGRFGNWLENRPDWCISRQRYWGIPIPIWYCEDTG 484
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 466 KEEAIGSFQELKARATKPLPEPF--DPHRPYVDQVELACACGGTMRRVPYVIDVWYDSGAMPFASLHYPFEHEEvFRESF 543
Cdd:TIGR00392 485 EPIVVGSIEELIELIELKGIDAWfeDLHRDFLDKITLKSGDGGEYRRVPDVLDVWFDSGSMPYASIHYPFENEK-FKEVF 563
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 544 PADFIAEGIDQTRGWFNSLHQLGVMLFGSIAFKNVICHGLILDEKGQKMSKSKGNVVDPWDIIRKFGADALRWYIyVSAP 623
Cdd:TIGR00392 564 PADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVINKYGADILRLYV-ASSD 642
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 624 PEADRRFGPNLVRETVRDYFLTLWNVYSFFVTYANLDR-PDLKNPPPPEKRPEMDRWLLARMQDLIQRVTEALEAYDPTT 702
Cdd:TIGR00392 643 PWEDLRFSDEILKQVVEKYRKIRWNTYRFLLTYANLDKfDPLFNSVAVEKFPEEDRWILSRLNSLVEEVNEALEKYNFHK 722
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 703 SARALRDFVVEDLSQWYVRRNRRRFWKNEDALDREAAYATLYEALVLVATLAAPFTPFLAEVLWQNLvrsVRLEAKESVH 782
Cdd:TIGR00392 723 VLRALQDFIVEELSNWYIRIIRDRLYCEAKDNDKRAAQTTLYYALLTLVRLLAPFLPHTAEEIYQNL---PGGEEEESVH 799
|
810 820 830
....*....|....*....|....*....|....
1JZQ_A 783 LADWPEADPALADEALVAQMRAVLKVVDLARAAR 816
Cdd:TIGR00392 800 LNLWPEVDEEFIDEALEANMAIVREIVEAFLALR 833
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
4-818 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 780.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 4 EVGEP---NFPKLEEEVLAFWKREKIFQKSVENRKGGPRYTVYEGPPTANGLPHVGHAQARSYKDLFPRYKTMRGYYAPR 80
Cdd:PLN02882 1 EVCEGkdfSFPKQEEKILSLWSEIDAFKTQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 81 RAGWDTHGLPVELEVEKKLGLKSKREIEAYGIERFNQACRESVFTYEKEWEAFTERIAYWVDLEDAYATLEPTYIESIWW 160
Cdd:PLN02882 81 RFGWDCHGLPVEYEIDKKLGIKRRDDVLKMGIDKYNEECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWW 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 161 SLKNLFDRGLLYRDHKVVPYCPRCGTPLSSHEVALGYKEIQDPSVYVRFPLkepkkLG-LEKASLLIWTTTPWTLPGNVA 239
Cdd:PLN02882 161 VFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAGLNYKDVSDPAVMVSFPI-----VGdPDNASFVAWTTTPWTLPSNLA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 240 AAVHPEYTYAafQVGDEA----LILEE---------------GLGRKLLGEGTQVLKTFPGKALEGLPYTP--PYPQALE 298
Cdd:PLN02882 236 LCVNPNFTYV--KVRNKYtgkvYIVAEsrlsalptakpkskkGSKPENAAEGYEVLAKVPGSSLVGKKYEPlfDYFSEFS 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 299 KGYFVVLAD-YVSQEDGTGIVHQAPAFGAEDLetaRV--------YGLPLLKTVDEEGKL--LVEPFKGLYFREANRAIL 367
Cdd:PLN02882 314 DTAFRVVADdYVTDDSGTGVVHCAPAFGEDDY---RVclangiieKGGNLPVPVDDDGCFteKVTDFSGRYVKDADKDII 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 368 RDLRGRGLLFKEESYLHSYPHCWRCSTPLMYYATESWFIKNTLFKDELIRNNQEIHWVPPHIKEGRYGEWLKNLVDWALS 447
Cdd:PLN02882 391 AAIKAKGRLVKSGSITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDYVKEKRFHNWLENARDWAVS 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 448 RNRYWGTPLPIWVCQACGKEEAIGSFQELKARATKPLpepFDPHRPYVDQVELACACG---GTMRRVPYVIDVWYDSGAM 524
Cdd:PLN02882 471 RSRFWGTPLPIWISDDGEEVVVIGSIAELEKLSGVKV---TDLHRHFIDHITIPSSRGpefGVLRRVDDVFDCWFESGSM 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 525 PFASLHYPFEHEEVFRESFPADFIAEGIDQTRGWFNSLHQLGVMLFGSIAFKNVICHGLILDEKGQKMSKSKGNVVDPWD 604
Cdd:PLN02882 548 PYAYIHYPFENKELFEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNE 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 605 IIRKFGADALRWYIYVSAPPEADR-RFGPNLVRETVRDYFLTLWNVYSFFVTyaNLDRPDLK-----NPPPPEKRPE--- 675
Cdd:PLN02882 628 VIDKYGADALRLYLINSPVVRAEPlRFKEEGVFGVVKDVFLPWYNAYRFLVQ--NAKRLEVEggapfVPLDLAKLQNsan 705
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 676 -MDRWLLARMQDLIQRVTEALEAYDPTTSARALRDFvVEDLSQWYVRRNRRRFWKNEDALDREAAYATLYEALVLVATLA 754
Cdd:PLN02882 706 vLDRWINSATQSLVKFVREEMGAYRLYTVVPYLVKF-IDNLTNIYVRFNRKRLKGRTGEEDCRTALSTLYNVLLTSCKVM 784
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....
1JZQ_A 755 APFTPFLAEVLWQNLvRSVRLEAKESVHLADWPEADPALADEALVAQMRAVLKVVDLARAARAK 818
Cdd:PLN02882 785 APFTPFFTEVLYQNL-RKVLPGSEESIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRER 847
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
17-630 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 624.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 17 VLAFWKREKIFQKSVENRKGGPRYTVYEGPPTANGLPHVGHAQARSYKDLFPRYKTMRGYYAPRRAGWDTHGLPVELEVE 96
Cdd:pfam00133 2 IYEFWDEQGYFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVVE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 97 KKLGLKSKREIEAYGIERFNQACRESVFTYEKEWEAFTERIAYWVDLEDAYATLEPTYIESIWWSLKNLFDRGLLYRDHK 176
Cdd:pfam00133 82 KKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGKK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 177 VVPYCPRCGTPLSSHEVAlgYKEIQDPSVYVRFPLKEPkklglEKASLLIWTTTPWTLPGNVAAAVHPEYTYAafqVGDE 256
Cdd:pfam00133 162 LVNWSPALNTALSNLEVE--YKDVKGPSIHVAFPLADD-----EGASLVIWTTTPWTLPGNTAVAVNPEFDYV---ITGE 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 257 ALILEEGLGRKL--LGEGTQVLKTFPGKALEGLPYTPPYpqaLEKGYFVVLADYVSQEDGTGIVHQAPAFGAEDLETARV 334
Cdd:pfam00133 232 GYILAEALLKSLykKGTDKKILEDFRGKELEGKEAIHPF---VNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQR 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 335 YGLPLLKTVDEEGKLL--VEPFKGLYFREANRAILRDLRGRGLLFKEESYLHSYPHCWRCSTPLMYYATESWFIKNTLFK 412
Cdd:pfam00133 309 HNLEVINPVDDDGTFTeeAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELA 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 413 DELIRNNQEIHWVpPHIKEGRYGEWLKNLVDWALSRNRYWGTPLPIWVCQACGKEEAIGSFQELKARATKPLPEPFDPHR 492
Cdd:pfam00133 389 DQALEAVEKVQFV-PKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELVAGRFEEEGSIKWLHR 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 493 PYVDQVELAcacGGTMRRVPYVIDVWYDSGAMPFASLHYPFEHEEVFRESFPADFIAEGIDQTRGWFNSLHQLGVMLFGS 572
Cdd:pfam00133 468 EAKDKLGYG---KGTLEQDEDVLDTWFSSGSWPFSTLGWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTGS 544
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*...
1JZQ_A 573 IAFKNVICHGLILDEKGQKMSKSKGNVVDPWDIIRKFGADALRWYIyVSAPPEADRRF 630
Cdd:pfam00133 545 VPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWL-ANSDYGRDINL 601
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
2-821 |
0e+00 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 590.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 2 FKEVGE-PNFPKLEEEVLAFWKREKIFQKSVENRKGGPRYTVYEGPPTANGLPHVGHAQARSYKDLFPRYKTMRGYYAPR 80
Cdd:PTZ00427 65 FTGVSEnPNIVEEEEKVLKYWKSIDAFNTSNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVER 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 81 RAGWDTHGLPVELEVEKKLGLKSKREIEAYGIERFNQACRESVFTYEKEWEAFTERIAYWVDLEDAYATLEPTYIESIWW 160
Cdd:PTZ00427 145 KFGWDCHGLPIEYEIEKENNINKKEDILKMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWW 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 161 SLKNLFDRGLLYRDHKVVPYCPRCGTPLSSHEVALGYKEIQDPSVYVRF-------------PLKEPKKLGLEKAS---- 223
Cdd:PTZ00427 225 VFSELYKNNYVYKSFKVMPYSCKCNTPISNFELNLNYKDTPDPSIIISFvlcsdfpkveeecNIEEDKQLLGEKYSvlyn 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 224 ------------------------LLIWTTTPWTLPGNVAAAVHPEYTY---------AAFQVGDEAL--ILEEglgRKL 268
Cdd:PTZ00427 305 nkrensnngnnnstnnvcyaqhseILAWTTTPWTLPSNLALCVNEHFTYlrihhvksnRVVIVGECRLewIMKE---LKW 381
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 269 LGEGTQVLKTFPGKALEGLPYTPPYPQALEK------GYFVVLADYVSQEDGTGIVHQAPAFGAEDLETARVYGLpllkt 342
Cdd:PTZ00427 382 NVEDLKIVNRFKGKELKGLRYKPLFTNFYEKynfkerAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGV----- 456
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 343 VDEEGKLLVEPF-------------KGLYFREANRAILRDLRGRGLLFKEESYLHSYPHCWRCSTPLMYYATESWFIKNT 409
Cdd:PTZ00427 457 IDPEKNIFIDPLdangyftneveevQNLYIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVS 536
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 410 LFKDELIRNNQEIHWVPPHIKEGRYGEWLKNLVDWALSRNRYWGTPLPIW--------VCQacgkeEAIGSFQELKArat 481
Cdd:PTZ00427 537 NSTNELVKNNETTYWIPAHIKEKKFHNWIKDAKDWCISRNRYWGTPIPIWadekmetvICV-----ESIKHLEELSG--- 608
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 482 kpLPEPFDPHRPYVDQVELACACGGT---MRRVPYVIDVWYDSGAMPFASLHYPFEHE-EVFRESFPADFIAEGIDQTRG 557
Cdd:PTZ00427 609 --VKNINDLHRHFIDHIEIKNPKGKTypkLKRIPEVFDCWFESGSMPYAKVHYPFSTEkEDFHKIFPADFIAEGLDQTRG 686
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 558 WFNSLHQLGVMLFGSIAFKNVICHGLILDEKGQKMSKSKGNVVDPWDIIRKFGADALRWYIYVSAPPEADR-RFGPNLVR 636
Cdd:PTZ00427 687 WFYTLLVISTLLFDKAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLINSVAVRAENlKFQEKGVN 766
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 637 ETVRDYFLTLWNVYSFF---VT-YANLDRPD-LKNPPPPEKRPE-MDRWLLARMQDLIQRVTEALEAYDPTTSARALRDF 710
Cdd:PTZ00427 767 EVVKSFILPFYHSFRFFsqeVTrYECLNKKQfLFNTDYIYKNDNiMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQF 846
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 711 vVEDLSQWYVRRNRRRFWKNEDALDREAAYATLYEALVLVATLAAPFTPFLAEVLWQNLVRSV----------------- 773
Cdd:PTZ00427 847 -IENLTNWYIRLNRDRMRGSLGEENCLQSLCTTYRTLHLFTVLMAPFTPFITEYIYQQLRRVKstnehnennetgntkeg 925
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*
1JZQ_A 774 ---RLEAKESVHLADWPEADP--ALADE--ALVAQMRAVLKvvdLARAARAKSGV 821
Cdd:PTZ00427 926 dlnRGVIHKSVHFIMLPQVDEkyIIDYEiiELIEKMKDVIL---LGRVLRERRKV 977
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
38-630 |
5.94e-146 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 432.43 E-value: 5.94e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 38 PRYTVYEGPPTANGLPHVGHAQARSYKDLFPRYKTMRGYYAPRRAGWDTHGLPVELEVEKKLGLKSKREIEAYGIERFNQ 117
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAEFNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 118 ACRESVFTYEKEWEAFTERIAYWVDLEDayatleptyiesiwwslknlfdrgllyrdhkvvpycprcgtplsshevalgy 197
Cdd:cd00818 81 KCREFALRYVDEQEEQFQRLGVWVDWEN---------------------------------------------------- 108
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 198 keiqdpsvyvrfplkepkklglekaslliwtttpwtlpgnvaaavhpeytyaafqvgdealileeglgrkllgegtqvlk 277
Cdd:cd00818 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 278 tfpgkaleglPYTPPYPQALEKGYFVvladyvsqedgtgivhqapafgaedletarvyglpllktvdeegkllvepFKGL 357
Cdd:cd00818 109 ----------PYKTMDPEYMESVWWV--------------------------------------------------FKQL 128
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 358 YfreanrailrdlrGRGLLFKEESYLHsyphcWrcstPLMYYATESWFIKNTLFKDELIRNNQEIHWVPPHIKEgRYGEW 437
Cdd:cd00818 129 H-------------EKGLLYRGYKVVP-----W----PLIYRATPQWFIRVTKIKDRLLEANDKVNWIPEWVKN-RFGNW 185
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 438 LKNLVDWALSRNRYWGTPLPIWVCQACGKEeaigsfqelkaratkplpepfdphrpyvdqvelacacggTMRRVPYVIDV 517
Cdd:cd00818 186 LENRRDWCISRQRYWGTPIPVWYCEDCGEV---------------------------------------LVRRVPDVLDV 226
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 518 WYDSGAMPFASLHYPFEHEEvFRESFPADFIAEGIDQTRGWFNSLHQLGVMLFGSIAFKNVICHGLILDEKGQKMSKSKG 597
Cdd:cd00818 227 WFDSGSMPYAQLHYPFENED-FEELFPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLG 305
|
570 580 590
....*....|....*....|....*....|...
1JZQ_A 598 NVVDPWDIIRKFGADALRWYIYVSAPPEADRRF 630
Cdd:cd00818 306 NYVDPQEVVDKYGADALRLWVASSDVYAEDLRF 338
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
7-821 |
1.94e-145 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 447.72 E-value: 1.94e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 7 EPNFPKLEEEVLAFWKREKIFQKSVENRKggPRYTVYEGPPTANGLPHVGHAQARSYKDLFPRYKTMRGY--YAPRraGW 84
Cdd:PRK13208 9 KYDPEELEEKWQKIWEEEGTYKFDPDERK--PVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYnvFFPQ--GW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 85 DTHGLPVELEVEKKLGLKsKREIEAygiERFNQACRESVFTYEKEWEAFTERIAYWVDLEDAYATLEPTYIESIWWSLKN 164
Cdd:PRK13208 85 DDNGLPTERKVEKYYGIR-KDDISR---EEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 165 LFDRGLLYRDHKVVPYCPRCGTPLSSHEValGYKEIQDPSVYVRFPLKEPKKLglekaslLIWTTTPWTLPGNVAAAVHP 244
Cdd:PRK13208 161 LYKKGLIYRAEAPVLWCPRCETAIAQAEV--EYREREGKLNYIKFPVEDGEEI-------EIATTRPELLPACVAVVVHP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 245 EytyaafqvgDEALileeglgRKLLGegtqvlKTFpgkaleglpYTPPYpqalekGYFV-VLAD-YVSQEDGTGIVhQAP 322
Cdd:PRK13208 232 D---------DERY-------KHLVG------KTA---------IVPLF------GVEVpILADpLVDPDFGTGAV-MIC 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 323 AFGAE-DLETARVYGLPLLKTVDEEGKLLVE--PFKGLYFREANRAILRDLRGRGLLFKEESYLHSYPHCWRCSTPLMYY 399
Cdd:PRK13208 274 TFGDKtDVTWWRELNLPTRIIIDEDGRMTEAagKLAGLTIEEARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEIL 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 400 ATESWFIKNTLFKDELIRNNQEIHWVPPHIKEgRYGEWLKNL-VDWALSRNRYWGTPLPIWVCQACGKEEaigsfqelka 478
Cdd:PRK13208 354 VTRQWFIKVLDLKEELLERGKEINWYPEHMRV-RLENWIEGLnWDWCISRQRYFGTPIPVWYCKDCGHPI---------- 422
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 479 ratkpLPEPFD-PHRPYVDQ--VELACACG-GTMRRVPYVIDVWYDSGAMPFASLHYPFEhEEVFRESFPADFIAEGIDQ 554
Cdd:PRK13208 423 -----LPDEEDlPVDPTKDEppGYKCPQCGsPGFEGETDVMDTWATSSITPLIVTGWERD-EDLFEKVFPMDLRPQGHDI 496
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 555 TRGW-FNSL---HQLgvmlFGSIAFKNVICHGLILDEKGQKMSKSKGNVVDPWDIIRKFGADALRWYIyVSAPPEADRRF 630
Cdd:PRK13208 497 IRTWlFYTIlraYLL----TGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLEKYGADAVRYWA-ASARLGSDTPF 571
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 631 GPNLVRETVRdyFLT-LWNVYSFFVTYAnldrPDLKNPPPPEKRPeMDRWLLARMQDLIQRVTEALEAYDPTTSARALRD 709
Cdd:PRK13208 572 DEKQVKIGRR--LLTkLWNASRFVLHFS----ADPEPDKAEVLEP-LDRWILAKLAKVVEKATEALENYDFAKALEEIES 644
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 710 FVVEDLSQWYVRRNRRRFWKNEDALDREAAYATLYEALVLVATLAAPFTPFLAEVLWQNLvrsvrleAKESVHLADWPEA 789
Cdd:PRK13208 645 FFWHVFCDDYLELVKSRAYGEDEEEEQKSARYTLYTVLDTLLRLLAPFLPFITEEVWSWL-------YGGSVHRASWPEP 717
|
810 820 830
....*....|....*....|....*....|..
1JZQ_A 790 DPALADEALVAQMRAVLKVVDLARAARAKSGV 821
Cdd:PRK13208 718 DEELIDEEDEELGELAKEILSAVRKYKSEAGL 749
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
9-813 |
5.81e-136 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 428.04 E-value: 5.81e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 9 NFPKLEEEVLAFWKREKIFQKSVENRKGGPrYTVYEGPPTANGLPHVGHAQARSYKDLFPRYKTMRGY---YAPrraGWD 85
Cdd:PLN02843 4 NSVTREPEIQKLWEENQVYKRVSDRNNGES-FTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKkvhYVP---GWD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 86 THGLPVELEVEKKLGLKSKREIEAygIERFNQACRESVFTYEKEWEAFtERIAYWVDLEDAYATLEPTYIESIWWSLKNL 165
Cdd:PLN02843 80 CHGLPIELKVLQSLDQEARKELTP--IKLRAKAAKFAKKTVDTQRESF-KRYGVWGDWENPYLTLDPEYEAAQIEVFGQM 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 166 FDRGLLYRDHKVVPYCPRCGTPLSshEVALGYKEIQ-DPSVYVRFPLKEPKKLG-------LEKASLLIWTTTPWTLPGN 237
Cdd:PLN02843 157 FLNGYIYRGRKPVHWSPSSRTALA--EAELEYPEGHvSKSIYVAFPVVSPSETSpeeleefLPGLSLAIWTTTPWTMPAN 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 238 VAAAVHPEYTYAAFQV----GDE-----------ALILEEGLGRKLL-------------GEGTQVLKTFPGKALEGLPY 289
Cdd:PLN02843 235 AAVAVNDKLQYSVVEVqsfsEDEstsggnkkkrpGNVLKEQQKLFLIvatdlvpaleakwGVKLVVLKTFPGSDLEGCRY 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 290 TPP-YPQaleKGYFVVLADYVSQEDGTGIVHQAPAFGAEDLETARVYGLPLLKTVDEEGKLLVE--PFKGL-YFREANRA 365
Cdd:PLN02843 315 IHPlYNR---ESPVVIGGDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEagQFSGLsVLGEGNAA 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 366 ILRDLRGRGLLFKEESYLHSYPHCWRCSTPLMYYATESWFIKNTLFKDELIRNNQEIHWVPPHiKEGRYGEWLKNLVDWA 445
Cdd:PLN02843 392 VVEALDEAGSLLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIPAQ-GENRIRAMVSGRSDWC 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 446 LSRNRYWGTPLPIWVCQACGK----EEAIGSFQELKAR----------ATKPLPEpfdphrPYVDQVElacacggTMRRV 511
Cdd:PLN02843 471 ISRQRTWGVPIPVFYHVETKEplmnEETIAHVKSIVAQkgsdawwymdVEDLLPE------KYRDKAS-------DYEKG 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 512 PYVIDVWYDSG---AMPFASlhypfeheevfRE--SFPADFIAEGIDQTRGWFNSLHQLGVMLFGSIAFKNVICHGLILD 586
Cdd:PLN02843 538 TDTMDVWFDSGsswAGVLGS-----------REglSYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLD 606
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 587 EKGQKMSKSKGNVVDPWDIIR---------KFGADALRWYIyVSAPPEADRRFGPNLVRETVrDYFLTLWNVYSFFVtyA 657
Cdd:PLN02843 607 EKGFKMSKSLGNVVDPRLVIEggknqkqepAYGADVLRLWV-ASVDYTGDVLIGPQILKQMS-DIYRKLRGTLRYLL--G 682
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 658 NLDRPDLKNPPPPEKRPEMDRWLLARMQDLIQRVTEALEAYDPTTSARALRDFVVEDLSQWYVRRNRRRFWKNE-DALDR 736
Cdd:PLN02843 683 NLHDWKPDNAVPYEDLPSIDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLYVGGtTSFTR 762
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 737 EAAYATLYEALVLVATLAAPFTPFLAEVLWQNLVRSVRLEAKESVHLADWPEADPA---LADE-----ALVAQMR-AVLK 807
Cdd:PLN02843 763 RSCQTVLAAHLLSLLRAIAPILPHLAEDAWQNLPFQEDGSAAESVFEAGWPTPNEEwlsFPAEdvdfwSLLLEVRdEVNK 842
|
....*.
1JZQ_A 808 VVDLAR 813
Cdd:PLN02843 843 VLESAR 848
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
9-821 |
5.34e-134 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 419.85 E-value: 5.34e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 9 NFPKLEEEVLAFWKREKIFQKSVEnrKGGPRYTVYEGPPTANGLPHVGHAQARSYKDLFPRYKTMRGYYAPRRAGWDTHG 88
Cdd:TIGR00422 6 DPHEVEKKWYKKWEKSGFFKPDGN--SNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 89 LPVELEVEKKLGLKSKREiEAYGIERFNQAC----RESVFTYEKEWEafteRIAYWVDLEDAYATLEPTYIESIWWSLKN 164
Cdd:TIGR00422 84 IATQVKVEKKLGAEGKTK-HDLGREEFREKIwewkEESGGTIKNQIK----RLGASLDWSRERFTMDEGLSKAVKEAFVR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 165 LFDRGLLYRDHKVVPYCPRCGTPLSSHEVAlgYKEIQDPSVYVRFPLKepkklGLEKASLLIWTTTPWTLPGNVAAAVHP 244
Cdd:TIGR00422 159 LYEKGLIYRGEYLVNWDPKLNTAISDIEVE--YKEVKGKLYYIRYPLA-----NGSKDYLVVATTRPETMFGDTAVAVHP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 245 EytyaafqvgDEALileeglgrkllgegtqvlKTFPGKALEgLPYTP---PypqalekgyfvVLAD-YVSQEDGTGIVHQ 320
Cdd:TIGR00422 232 E---------DERY------------------KHLIGKKVI-LPLTGrkiP-----------IIADeYVDMEFGTGAVKV 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 321 APAFGAEDLETARVYGLPLLKTVDEEGKLLVE--PFKGLYFREANRAILRDLRGRGLLFKEESYLHSYPHCWRCSTPLMY 398
Cdd:TIGR00422 273 TPAHDFNDYEWGKRHNLEFINILDEDGLLNENagKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEP 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 399 YATESWFIKNTLFKDELIR--NNQEIHWVPPHIkEGRYGEWLKNLVDWALSRNRYWGTPLPIWVCQACGkeEAIGSFQEl 476
Cdd:TIGR00422 353 LLSKQWFVKVEKLADKALEaaEEGEIKFVPKRM-EKRYLNWLRNIKDWCISRQLIWGHRIPVWYCKECG--EVYVAKEE- 428
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 477 karatkplPEPFDPHRPYVDQvelacacggTMRRVPYVIDVWYDSGAMPFASLHYPfEHEEVFRESFPADFIAEGIDQTR 556
Cdd:TIGR00422 429 --------PLPDDKTNTGPSV---------ELEQDTDVLDTWFSSSLWPFSTLGWP-DETKDLKKFYPTDLLVTGYDIIF 490
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 557 GW-----FNSLHQLGvmlfgSIAFKNVICHGLILDEKGQKMSKSKGNVVDPWDIIRKFGADALRWYIYVSAPPEADRRFG 631
Cdd:TIGR00422 491 FWvarmiFRSLALTG-----QVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASLVTPGDDINFD 565
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 632 PNLVrETVRDYFLTLWNVYSFFVTyaNLDRPDLKNPPPPEKRPeMDRWLLARMQDLIQRVTEALEAYDPTTSARALRDFV 711
Cdd:TIGR00422 566 WKRV-ESARNFLNKLWNASRFVLM--NLSDDLELSGGEEKLSL-ADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFI 641
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 712 VEDLSQWYVRRNRRRFWkNEDALDREAAYATLYEALVLVATLAAPFTPFLAEVLWQNLVrsvrlEAKESVHLADWPEADP 791
Cdd:TIGR00422 642 WNDFCDWYIELVKYRLY-NGNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFK-----EGADSIMLQSYPVVDA 715
|
810 820 830
....*....|....*....|....*....|
1JZQ_A 792 ALADEALVAQMRAVLKVVDLARAARAKSGV 821
Cdd:TIGR00422 716 EFVDEEAEKAFELLKEIIVSIRNLKAESNI 745
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
12-821 |
4.59e-92 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 312.31 E-value: 4.59e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 12 KLEEEVLAFWKREKIFQKSvENRKGGPRYTVYEGPPTANGLPHVGHAQARSYKDLFPRYKTMRGYYAPRRAGWDTHGLPV 91
Cdd:PRK14900 23 EVEARWYPFWQERGYFHGD-EHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIAT 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 92 ELEVEKKLGLKSKREIEAYGIERFnqacRESVFtyekEW-EAFTERIAYW-------VDLEDAYATLEPTYIESIWWSLK 163
Cdd:PRK14900 102 QMIVEKELKKTEKKSRHDLGREAF----LERVW----AWkEQYGSRIGEQhkalgasLDWQRERFTMDEGLSRAVREVFV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 164 NLFDRGLLYRDHKVVPYCPRCGTPLSSHEVAlgYKEIQDPSVY-VRFPLKEPKKlglekaSLLIWTTTPWTLPGNVAAAV 242
Cdd:PRK14900 174 RLHEEGLIYREKKLINWCPDCRTALSDLEVE--HEEAHQGELWsFAYPLADGSG------EIVVATTRPETMLGDTAVAV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 243 HPEytyaafqvgDE---ALIleeglGRKLLGEGTQvlKTFPgkaleglpytppypqalekgyFVVLADYVSQEDGTGIVH 319
Cdd:PRK14900 246 HPL---------DPrymALH-----GKKVRHPITG--RTFP---------------------IVADAILVDPKFGTGAVK 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 320 QAPAFGAEDLETARVYGLPLLKTVDEEGKLLVE--PFKGLYFREANRAILRDLRGRGLLFKEESYLHSYPHCWRCSTPLM 397
Cdd:PRK14900 289 VTPAHDFNDFEVGKRHGLEMITVIGPDGRMTAEagPLAGLDRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILE 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 398 YYATESWFIK-NTLFKDELIRNNQEIHWVPPHIKEGRYGEWLKNLVDWALSRNRYWGTPLPIWVCQACgkeeaigsfQEL 476
Cdd:PRK14900 369 PLLSDQWYVRiEPLARPAIEAVEQGRTRFIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPAWYCPDG---------HVT 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 477 KARATkplPEpfdphrpyvdqvelACA-CGG-TMRRVPYVIDVWYDSGAMPFASLHYPfEHEEVFRESFPADFIAEGIDQ 554
Cdd:PRK14900 440 VARET---PE--------------ACStCGKaELRQDEDVLDTWFSSGLWPFSTMGWP-EQTDTLRTFYPTSVMETGHDI 501
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 555 TRGWFNSLHQLGVMLFGSIAFKNVICHGLILDEKGQKMSKSKGNVVDPWDIIRKFGADALRWYIYVSAPPEADRRFGPNL 634
Cdd:PRK14900 502 IFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTLAALTAQGRDIKLAKER 581
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 635 VrETVRDYFLTLWNVYSFfvTYANLDRPDLKNPPPPEK-RPEMDRWLLARMQDLIQRVTEALEAYDPTTSARALRDFVVE 713
Cdd:PRK14900 582 I-EGYRAFANKLWNASRF--ALMNLSGYQERGEDPARLaRTPADRWILARLQRAVNETVEALEAFRFNDAANAVYAFVWH 658
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 714 DLSQWYVRRNRRRFWkNEDALDREAAYATLYEALVLVATLAAPFTPFLAEVLWQNLVRSVRLEA-KESVHLADWPEadPA 792
Cdd:PRK14900 659 ELCDWYIELAKEALA-SEDPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLRAQVGASAwADSVLAAEYPR--KG 735
|
810 820
....*....|....*....|....*....
1JZQ_A 793 LADEALVAQMRAVLKVVDLARAARAKSGV 821
Cdd:PRK14900 736 EADEAAEAAFRPVLGIIDAVRNIRGEMGI 764
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
14-821 |
8.44e-90 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 302.41 E-value: 8.44e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 14 EEEVLAFWKREKIFQKSVENRKggpRYTVYEGPPTANGLPHVGHA-----QarsykDLFPRYKTMRGY---YAPrraGWD 85
Cdd:PRK05729 15 EAKWYQKWEEKGYFKPDDNSKK---PFSIVIPPPNVTGSLHMGHAlnntlQ-----DILIRYKRMQGYntlWLP---GTD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 86 THGLPVELEVEKKL---GlKSKREIeayGIERFnqacresvftYEKEWE-------AFTE---RIAYWVDLEDAYATLEP 152
Cdd:PRK05729 84 HAGIATQMVVERQLaaeG-KSRHDL---GREKF----------LEKVWEwkeesggTITNqlrRLGASCDWSRERFTMDE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 153 TYIESIWWSLKNLFDRGLLYRDHKVVPYCPRCGTPLSSHEVAlgYKEIQDPSVYVRFPLKEPKKlglekaSLLIWTTTPW 232
Cdd:PRK05729 150 GLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVE--YKEVKGKLWHIRYPLADGSD------YLVVATTRPE 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 233 TLPGNVAAAVHPEytyaafqvgDE---ALIleeglGRKLLgegtqvlktfpgkalegLPYT----PpypqalekgyfvVL 305
Cdd:PRK05729 222 TMLGDTAVAVNPE---------DErykHLI-----GKTVI-----------------LPLVgreiP------------II 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 306 AD-YVSQEDGTGIVHQAPAFGAEDLETARVYGLPLLKTVDEEGKL--LVEPFKGLYFREANRAILRDLRGRGLLFKEESY 382
Cdd:PRK05729 259 ADeYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTIneNPGEYQGLDRFEARKAIVADLEELGLLVKIEPH 338
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 383 LHSYPHCWRCSTPLMYYATESWFIKNTLFKDELIR--NNQEIHWVPPHIkEGRYGEWLKNLVDWALSRNRYWGTPLPIWV 460
Cdd:PRK05729 339 THSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEavENGEIKFVPERW-EKTYFHWMENIQDWCISRQLWWGHRIPAWY 417
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 461 CQAcGKEeaigsfqelkaratkplpepfdphrpYVDQVELACACGGTMRRVPYVIDVWYDSGAMPFASLHYPfEHEEVFR 540
Cdd:PRK05729 418 DED-GEV--------------------------YVGREEPEAREKALLTQDEDVLDTWFSSALWPFSTLGWP-EKTEDLK 469
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 541 ESFPADFIAEGID-----QTRGWFNSLHqlgvmLFGSIAFKNVICHGLILDEKGQKMSKSKGNVVDPWDIIRKFGADALR 615
Cdd:PRK05729 470 RFYPTSVLVTGFDiiffwVARMIMMGLH-----FTGQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALR 544
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 616 WYIYVSAPPEADRRFGPNLVrETVRDyFLT-LWNVySFFVtYANLDRPDLKNPPPPEKRPEMDRWLLARMQDLIQRVTEA 694
Cdd:PRK05729 545 FTLAALASPGRDIRFDEERV-EGYRN-FANkLWNA-SRFV-LMNLEGADVGELPDPEELSLADRWILSRLNRTVAEVTEA 620
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 695 LEAYDPTTSARALRDFVVEDLSQWYVRRNRRRFWKNEdaldREAAYATLYEALVLVATLAAPFTPFLAEVLWQNLvrsVR 774
Cdd:PRK05729 621 LDKYRFDEAARALYEFIWNEFCDWYLELAKPVLQEAA----KRATRATLAYVLEQILRLLHPFMPFITEELWQKL---AP 693
|
810 820 830 840
....*....|....*....|....*....|....*....|....*..
1JZQ_A 775 LEAKESVHLADWPEADPALaDEALVAQMRAVLKVVDLARAARAKSGV 821
Cdd:PRK05729 694 LGIEESIMLAPWPEADEAI-DEAAEAEFEWLKELITAIRNIRAEMNI 739
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
14-821 |
1.97e-89 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 301.59 E-value: 1.97e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 14 EEEVLAFWKREKIFQKSVEnrKGGPRYTVYEGPPTANGLPHVGHA-----QarsykDLFPRYKTMRGYYA---PrraGWD 85
Cdd:COG0525 13 EAKWYQYWEENGYFKADPD--SDKEPFTIVIPPPNVTGSLHMGHAlnntlQ-----DILIRYKRMQGYNTlwqP---GTD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 86 tH-GLPVELEVEKKL---GlKSKREIeayGierfnqacREsvftyekeweAFTERIAYW------------------VDL 143
Cdd:COG0525 83 -HaGIATQAVVERQLaeeG-KSRHDL---G--------RE----------KFLERVWEWkeesggtitnqlrrlgasCDW 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 144 EDAYATLEPTYIESIWWSLKNLFDRGLLYRDHKVVPYCPRCGTPLSSHEVAlgYKEIQDPSVYVRFPLKEPKKlglekaS 223
Cdd:COG0525 140 SRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVE--HEEVKGHLWHIRYPLADGSG------Y 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 224 LLIWTTTPWTLPGNVAAAVHPEytyaafqvgDE---ALIleeglGRKLLgegtqvlktfpgkalegLPYT----Ppypqa 296
Cdd:COG0525 212 IVVATTRPETMLGDTAVAVHPE---------DErykHLI-----GKTVI-----------------LPLVgreiP----- 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 297 lekgyfvVLAD-YVSQEDGTGIVHQAPAFGAEDLETARVYGLPLLKTVDEEGKL--LVEPFKGLYFREANRAILRDLRGR 373
Cdd:COG0525 256 -------IIADeYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGTIneNAGKYRGLDRFEARKAIVADLEEL 328
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 374 GLLFKEESYLHSYPHCWRCSTPLMYYATESWFIKNTLFKDELIR--NNQEIHWVPPHIkEGRYGEWLKNLVDWALSRNRY 451
Cdd:COG0525 329 GLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEavEDGEIKFVPERW-EKTYFHWMENIRDWCISRQLW 407
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 452 WGTPLPIWVCQA----CGKEEaigsfqelkaratkplPEpfdphrpyvdqvelACA-CGGT-MRRVPYVIDVWYDSGAMP 525
Cdd:COG0525 408 WGHRIPAWYCPDgevyVARTE----------------PE--------------ACAkAGSVnLTQDEDVLDTWFSSALWP 457
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 526 FASLHYPFEHEEvFRESFPAD----------FiaegidqtrgW-----FNSLHQLGvmlfgSIAFKNVICHGLILDEKGQ 590
Cdd:COG0525 458 FSTLGWPEKTED-LKYFYPTSvlvtgfdiifF----------WvarmiMMGLHFTG-----EVPFKDVYIHGLVRDEQGR 521
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 591 KMSKSKGNVVDPWDIIRKFGADALRWYIYVSAPPEADRRFGPNLVrETVRDyFLT-LWNVySFFVTyANLDRPDLKNPPP 669
Cdd:COG0525 522 KMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIKFDEERV-EGYRN-FANkLWNA-SRFVL-MNLEGFDPGLDPD 597
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 670 PEKRPEMDRWLLARMQDLIQRVTEALEAYDPTTSARALRDFVVEDLSQWYVRRNRRRFWkNEDALDREAAYATLYEALVL 749
Cdd:COG0525 598 PEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVWNEFCDWYLELAKPRLY-GGDEAAKRETRATLVYVLEQ 676
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
1JZQ_A 750 VATLAAPFTPFLAEVLWQNLvrsVRLEAKESVHLADWPEADPALADEALVAQMRAVLKVVDLARAARAKSGV 821
Cdd:COG0525 677 ILRLLHPFMPFITEEIWQKL---PPRKEGESIMLAPWPEADEELIDEEAEAEFEWLKEVISAIRNIRAEMNI 745
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
630-813 |
5.00e-86 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 270.96 E-value: 5.00e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 630 FGPNLVRETVRDYFLTLWNVYSFFVTYANLDRPDLKNP-PPPEKRPEMDRWLLARMQDLIQRVTEALEAYDPTTSARALR 708
Cdd:cd07961 1 FSEKGVREVVRKVLLPLWNAYRFFVTYANLDGFDPGKDdDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 709 DFVVEdLSQWYVRRNRRRFWKNEDALDREAAYATLYEALVLVATLAAPFTPFLAEVLWQNLVRSVRlEAKESVHLADWPE 788
Cdd:cd07961 81 EFIDE-LTNWYIRRNRKRFWGEEGDDDKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRRELG-DAPESVHLLDWPE 158
|
170 180
....*....|....*....|....*
1JZQ_A 789 ADPALADEALVAQMRAVLKVVDLAR 813
Cdd:cd07961 159 VDESLIDEELEEAMELVREIVELGR 183
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
399-630 |
1.68e-77 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 253.50 E-value: 1.68e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 399 YATESWFIKNTLFKDELIRNNQEIHWVPPHIKEgRYGEWLKNLVDWALSRNRYWGTPLPiwvcqacgkeeaigsfqelka 478
Cdd:cd00668 137 RITEQWFFDMPKFKEKLLKALRRGKIVPEHVKN-RMEAWLESLLDWAISRQRYWGTPLP--------------------- 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 479 ratkplpepfdphrpyvdqvelacacggtmrrvPYVIDVWYDSGAMPFASLHYPFEHEEvFRESFPADFIAEGIDQTRGW 558
Cdd:cd00668 195 ---------------------------------EDVFDVWFDSGIGPLGSLGYPEEKEW-FKDSYPADWHLIGKDILRGW 240
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
1JZQ_A 559 FNSLHQLGVMLFGSIAFKNVICHGLILDEKGQKMSKSKGNVVDPWDIIRKFGADALRWYIYVSAPPEADRRF 630
Cdd:cd00668 241 ANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVEKYGADALRYYLTSLAPYGDDIRL 312
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
14-788 |
2.78e-67 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 241.38 E-value: 2.78e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 14 EEEVLAFWKREKIFQKSVEnrKGGPRYTVYEGPPTANGLPHVGHAQARSYKDLFPRYKTMRGYYAPRRAGWDTHGLPVEL 93
Cdd:PLN02943 66 EERIYNWWESQGYFKPNFD--RGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQL 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 94 EVEKKLGLKSKREIEaYGIERFNQACRESVFTYEKEWEAFTERIAYWVDLEDAYATLEPTYIESIWWSLKNLFDRGLLYR 173
Cdd:PLN02943 144 VVEKMLASEGIKRTD-LGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQ 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 174 DHKVVPYCPRCGTPLSSHEVAlgYKEIQDPSVYVRFPLKepkklGLEKASLLIWTTTPWTLPGNVAAAVHPEYTYAAFQV 253
Cdd:PLN02943 223 GSYMVNWSPNLQTAVSDLEVE--YSEEPGTLYYIKYRVA-----GGSEDFLTIATTRPETLFGDVAIAVNPEDDRYSKYI 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 254 GDEALILEEGlGRkllgegtqvlktfpgkaleglpYTPpypqalekgyfvVLAD-YVSQEDGTGIVHQAPAFGAEDLETA 332
Cdd:PLN02943 296 GKMAIVPMTY-GR----------------------HVP------------IIADrYVDKDFGTGVLKISPGHDHNDYLLA 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 333 RVYGLPLLKTVDEEGKLlvEPFKGLYFREANRAILRDLRGRGLLFKEESYLHSYPHCWRCSTPLMYYATESWFIKNTLFK 412
Cdd:PLN02943 341 RKLGLPILNVMNKDGTL--NEVAGLYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLA 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 413 DELIR--NNQEIHWVPPHIkEGRYGEWLKNLVDWALSRNRYWGTPLPIW--VCQACGKEEAIGSFQE---LKARATkplp 485
Cdd:PLN02943 419 EKALKavENGELTIIPERF-EKIYNHWLSNIKDWCISRQLWWGHRIPVWyiVGKDCEEDYIVARSAEealEKAREK---- 493
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 486 epfdphrpYVDQVELAcacggtmrRVPYVIDVWYDSGAMPFASLHYPFEHEEVFRESFPADFIAEGIDQTRGWFNSLHQL 565
Cdd:PLN02943 494 --------YGKDVEIY--------QDPDVLDTWFSSALWPFSTLGWPDVSAEDFKKFYPTTVLETGHDILFFWVARMVMM 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 566 GVMLFGSIAFKNVICHGLILDEKGQKMSKSKGNVVDPWDIIRKFGADALRWYIyvsAPPEADRRFGPNLVRETVRDYFLT 645
Cdd:PLN02943 558 GIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTL---ALGTAGQDLNLSTERLTSNKAFTN 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 646 -LWNVYSFFV----------TYANLDRPDLKNPPPPEKRPEMDRWLLARMQDLIQRVTEALEAYDPTTSARALRDFVVED 714
Cdd:PLN02943 635 kLWNAGKFVLqnlpsqsdtsAWEHILACKFDKEESLLSLPLPECWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFFWSD 714
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
1JZQ_A 715 LSQWYVRRNRRRFWKNEDALDREAAYATLYEALVLVATLAAPFTPFLAEVLWQNLVrsvrlEAKESVHLADWPE 788
Cdd:PLN02943 715 FADWYIEASKTRLYHSGDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQALP-----YRKEALIVSPWPQ 783
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
11-821 |
3.39e-67 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 241.45 E-value: 3.39e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 11 PK-LEEEVLAFWKREKIFQKS--VENRKGGPRYTVYEGPPTANGLPHVGHAQARSYKDLFPRYKTMRGY---YAPrraGW 84
Cdd:PTZ00419 30 PKeVESGWYEWWEKSGFFKPAedAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDetlWVP---GT 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 85 DTHGLPVELEVEKKLGLKSKREIEAYGIERFnqacresvftYEKEWEaFTE-----------RIAYWVDLEDAYATLEPT 153
Cdd:PTZ00419 107 DHAGIATQVVVEKKLMKEENKTRHDLGREEF----------LKKVWE-WKDkhgnnicnqlrRLGSSLDWSREVFTMDEQ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 154 YIESIWWSLKNLFDRGLLYRDHKVVPYCPRCGTPLSSHEVAlgYKEIQDPS----------------VYVRFPLKEPkkl 217
Cdd:PTZ00419 176 RSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVE--FEEIEKPTkitipgydkkvevgvlWHFAYPLEDS--- 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 218 glEKASLLIWTTTPWTLPGNVAAAVHPEytyaafqvgDEalileeglgRkllgegtqvLKTFPGKALEGlPYTPPypqal 297
Cdd:PTZ00419 251 --GQEEIVVATTRIETMLGDVAVAVHPK---------DE---------R---------YKKLHGKELIH-PFIPD----- 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 298 EKgyFVVLAD--YVSQEDGTGIVHQAPAFGAEDLETARVYGLPLLKTVDEEGKLLVE--PFKGLYFREANRAILRDLRGR 373
Cdd:PTZ00419 296 RK--IPIIADdeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFTLDGKINENggEFAGMHRFDCRRKIEEELKEM 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 374 GLLFKEESYLHSYPHCWRCSTPLMYYATESWFIKNTLFKDELIRN--NQEIHWVPPHiKEGRYGEWLKNLVDWALSRNRY 451
Cdd:PTZ00419 374 GLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKRAVEAvrNGELKIIPSS-HENVWYHWLENIQDWCISRQLW 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 452 WGTPLPIWVCQACGKEEAIG---------SFQELKARATKPLPEPfdphrpyvdqvelacACGGTMRRVPYVIDVWYDSG 522
Cdd:PTZ00419 453 WGHRIPAYRVISKGPETDPSdeepwvvarSEEEALEKAKKKFGLS---------------EEDFELEQDEDVLDTWFSSG 517
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 523 AMPFASLHYPFEHEEvFRESFPADFIAEGIDQTRGWFNSLHQLGVMLFGSIAFKNVICHGLILDEKGQKMSKSKGNVVDP 602
Cdd:PTZ00419 518 LFPFSTLGWPDQTDD-LQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNVIDP 596
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 603 WDIIRKFGADALRWYIYVSAPPE----------------------ADR-RFG----------PNL-VRETV--RDYFLTL 646
Cdd:PTZ00419 597 LEVIEGISLQDLNQKLYEGNLPEkeikraielqkkefpngipecgTDAlRFGllaytqqgrnINLdINRVVgyRHFCNKL 676
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 647 WNVYSFFVTYANLDRPDLK----NPPPPEKRPEMDRWLLARMQDLIQRVTEALEAYDPTTSARALRDFVVEDLSQWYVRR 722
Cdd:PTZ00419 677 WNAVKFALMKLLKDFNLPNstlfKPNNVESLPWEDKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFWLYELCDVYLEL 756
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 723 NRRRFWKNEDALDREAAYATLYEALVLVATLAAPFTPFLAEVLWQNLVRSVRLEakESVHLADWPEADPALADEALVAQM 802
Cdd:PTZ00419 757 IKPRLSKQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPNYLRKS--ESISIAKYPQPNPGWNNEALDEEM 834
|
890
....*....|....*....
1JZQ_A 803 RAVLKVVDLARAARAKSGV 821
Cdd:PTZ00419 835 KIIMSIVKSIRSLIATLGI 853
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
38-630 |
2.19e-58 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 204.02 E-value: 2.19e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 38 PRYTVYEGPPTANGLPHVGHAQARSYKDLFPRYKTMRGYYAPRRAGWDTHGLPVELEVEKKLGLKSKREIEaYGIERFNQ 117
Cdd:cd00817 1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKTRHD-LGREEFLE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 118 ACRESVFTYEKEWEAFTERIAYWVDLEDAYATLEPTYIESIWWSLKNLFDRGLLYRDHKVVPYCPRCGTPLSshevalgy 197
Cdd:cd00817 80 KCWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAIS-------- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 198 keiqdpsvyvrfplkepkklglekaslliwtttpwtlpgnvaaavhpeytyaafqvgdealileeglgrkllgegtqvlk 277
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 278 tfpgkaleglpytppypqalekgyfvvladyvsqedgtgivhqapafgaeDLEtarvyglpllktVDEEGKLLVEPfkgl 357
Cdd:cd00817 152 --------------------------------------------------DIE------------VCSRSGDVIEP---- 165
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 358 yfreanrailrdlrgrgllfkeesylhsyphcwrcstplmyYATESWFIKNTLFKDELIR--NNQEIHWVPPHIKEgRYG 435
Cdd:cd00817 166 -----------------------------------------LLKPQWFVKVKDLAKKALEavKEGDIKFVPERMEK-RYE 203
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 436 EWLKNLVDWALSRNRYWGTPLPIWVCQACGKEEAIGSFqelkaratkplPEPFDPHRPyvdqvELACACGG-TMRRVPYV 514
Cdd:cd00817 204 NWLENIRDWCISRQLWWGHRIPAWYCKDGGHWVVAREE-----------DEAIDKAAP-----EACVPCGGeELKQDEDV 267
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 515 IDVWYDSGAMPFASLHYPfEHEEVFRESFPADFIAEGIDQTRGWFNSLHQLGVMLFGSIAFKNVICHGLILDEKGQKMSK 594
Cdd:cd00817 268 LDTWFSSSLWPFSTLGWP-EETKDLKKFYPTSLLVTGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSK 346
|
570 580 590
....*....|....*....|....*....|....*.
1JZQ_A 595 SKGNVVDPWDIIRKFGADALRWYIYVSAPPEADRRF 630
Cdd:cd00817 347 SLGNVIDPLDVIDGYGADALRFTLASAATQGRDINL 382
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
39-178 |
6.45e-57 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 197.64 E-value: 6.45e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 39 RYTVYEGPPTANGLPHVGHAQARSYKDLFPRYKTMRGYYAPRRAGWDTHGLPVELEVEKKLGLKSKREIeaygIERFNQA 118
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIW----IEEFRED 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 119 CRESVFTYEKEWEAFTERIAYWVDLEDAYATLEPTYIESIWWSLKNLFDRGLLYRDHKVV 178
Cdd:cd00668 77 PKEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPV 136
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
13-818 |
5.27e-44 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 172.01 E-value: 5.27e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 13 LEEEVLAFWKREKIFQKSVENRKggPRYTVYEGPPTANGLPHVGHAQARSYKDLFPRYKTMRGYYAPRRAGWDTHGLPVE 92
Cdd:PLN02381 105 VEKSWYAWWEKSGYFGADAKSSK--PPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIATQ 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 93 LEVEKKLGLKSKREIEAYGIERFnqacRESVFTYEKEWEAFT----ERIAYWVDLEDAYATLEPTYIESIWWSLKNLFDR 168
Cdd:PLN02381 183 VVVEKKLMRERHLTRHDIGREEF----VSEVWKWKDEYGGTIlnqlRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKE 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 169 GLLYRDHKVVPYCPRCGTPLSSHEVAL------------GYKEIQDPSVYVRF--PLKEpkklGLekASLLIWTTTPWTL 234
Cdd:PLN02381 259 GLIYRDIRLVNWDCTLRTAISDVEVDYidikertllkvpGYDKPVEFGVLTSFayPLEG----GL--GEIVVATTRIETM 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 235 PGNVAAAVHPEytyaafqvgDEalileeglgRKLLGEGTQVLKTFPGKALEglpytppypqalekgyFVVLADYVSQEDG 314
Cdd:PLN02381 333 LGDTAIAIHPD---------DE---------RYKHLHGKFAVHPFNGRKLP----------------IICDAILVDPNFG 378
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 315 TGIVHQAPAFGAEDLETARVYGLPLLKTVDEEGKLLV---EPFKGLYFREANRAILRDLRGRGLLFKEESYLHSYPHCWR 391
Cdd:PLN02381 379 TGAVKITPAHDPNDFEVGKRHNLEFINIFTDDGKINSnggSEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSR 458
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 392 CSTPLMYYATESWFIK-NTLFKDEL----IRNNQEIHWVPPHIkEGRYGEWLKNLVDWALSRNRYWGTPLPIW-VCQACG 465
Cdd:PLN02381 459 TNDVVEPMIKPQWFVNcSSMAKQALdaaiDGENKKLEFIPKQY-LAEWKRWLENIRDWCISRQLWWGHRIPAWyVTLEDD 537
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 466 KEEAIGSF----------QELKARATKPLP-EPFDphrpyvdqvelacacggtMRRVPYVIDVWYDSGAMPFASLHYPFE 534
Cdd:PLN02381 538 QLKELGSYndhwvvarneSDALLEASQKFPgKKFE------------------LSQDPDVLDTWFSSGLFPLSVLGWPDD 599
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 535 HEEvFRESFPADFIAEGIDQTRGWFNSLHQLGVMLFGSIAFKNVICHGLILDEKGQKMSKSKGNVVDPWDII-------- 606
Cdd:PLN02381 600 TDD-LKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVIngislegl 678
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 607 ----------------------RKF-------GADALRWYIyVSAPPEADRrfgPNLVRETV---RDYFLTLWNVYSFFV 654
Cdd:PLN02381 679 hkrleegnldpkelvvakegqkKDFpngiaecGTDALRFAL-VSYTAQSDK---INLDILRVvgyRQWCNKLWNAVRFAM 754
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 655 TYANLDRpdlkNPP---PPEKRPEMDRWLLARMQDLIQRVTEALEAYDPTTSARALR--------DFVVEDLSQWYVRRN 723
Cdd:PLN02381 755 SKLGDDY----TPPatlSVETMPFSCKWILSVLNKAISKTVSSLDAYEFSDAASTVYswwqyqfcDVFIEAIKPYFAGDN 830
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 724 RrrfwknEDALDREAAYATLYEALVLVATLAAPFTPFLAEVLWQNLVRSVRLEAKESVHLADWPEADPALADEALVAQMR 803
Cdd:PLN02381 831 P------EFASERAAAQDTLWICLDTGLRLLHPFMPFVTEELWQRLPQPKDHTRKDSIMISEYPSAVEAWTNEKVEYEMD 904
|
890
....*....|....*
1JZQ_A 804 AVLKVVDLARAARAK 818
Cdd:PLN02381 905 LVLSTVKCLRSLRAE 919
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
53-810 |
1.76e-40 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 160.80 E-value: 1.76e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 53 PHVGHAqaRSY--KDLFPRYKTMRGYYAPRRAGWDTHGLPVeLEVEKKLGLKSKREIEAYG---------IERFNQAcrE 121
Cdd:PRK12300 1 LHVGHG--RTYtiGDVIARYKRMRGYNVLFPMAFHVTGTPI-LGIAERIARGDPETIELYKslygipeeeLEKFKDP--E 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 122 SVFTY-EKEWEAFTERIAYWVDLEDAYATLEPTYIESIWWSLKNLFDRGLLYRDHKVVPYCPRCGTPLSSHEVALGY-KE 199
Cdd:PRK12300 76 YIVEYfSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDGEePE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 200 IQDPSVyVRFPlkepkklGLEKASLLIWTTTPWTLPGNVAAAVHPEYTYAAFQVGDEALILEEGLGRKLL--GEGTQVLK 277
Cdd:PRK12300 156 IVEYTL-IKFE-------ESEDLILPAATLRPETIFGVTNLWVNPDATYVKAEVDGEKWIVSKEAAEKLSfqDRDVEIIE 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 278 TFPGKALEGL----PYT----PPYPqalekgyfvvlADYVSQEDGTGIVHQAPA------FGAEDL----ETARVYGLPL 339
Cdd:PRK12300 228 EIKGSELIGKkvknPVTgkevPILP-----------ADFVDPDNGTGVVMSVPAhapydyVALRDLkknkELLDVIEPIP 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 340 LKTVDEEGKLL--------------------------------------VEPFKGLYFREANRAILRDLRGRGLLFK--E 379
Cdd:PRK12300 297 LIEVEGYGEFPakevveklgiksqedpeleeatkevyraefhkgvlkenTGEYAGKPVREAREKITKDLIEKGIADImyE 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 380 ESYLHSYphCwRCSTPLMYYATE-SWFIK--NTLFKD---ELIrNNQEIhwVPPHIKE--GRYGEWLKnlvDWALSRNRY 451
Cdd:PRK12300 377 FSNRPVY--C-RCGTECVVKVVKdQWFIDysDPEWKElahKAL-DNMEI--IPEEYRKefENTIDWLK---DRACARRRG 447
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 452 WGTPLPiWvcqacGKEEAIGSF----------------QELKARATKPLPEPFDphrpYV-----DQVELACACGG---- 506
Cdd:PRK12300 448 LGTRLP-W-----DEEWIIESLsdstiymayytiahkiREYGIKPEQLTPEFFD----YVflgkgDPEEVSKKTGIpkei 517
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 507 --TMRR-VPYvidvWY--DS--GAMPFASLH---YPFEHEEVFRESF-PAdfiaegidqtrgwfnslhqlGVMLFGsiaf 575
Cdd:PRK12300 518 leEMREeFLY----WYpvDWrhSGKDLIPNHltfFIFNHVAIFPEEKwPR--------------------GIVVNG---- 569
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 576 knvichgLILDEkGQKMSKSKGNVVDPWDIIRKFGADALRWYIYVSAPPEADRRFGPNLVRETVRdyflTLWNVYSFFVT 655
Cdd:PRK12300 570 -------FVLLE-GKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQDADWREKEVESVRR----QLERFYELAKE 637
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 656 YANLDRPDLKNPPppekrpemDRWLLARMQDLIQRVTEALEAYDpttsaraLRDFVVE-------DLSqWYVRRNrrrfw 728
Cdd:PRK12300 638 LIEIGGEEELRFI--------DKWLLSRLNRIIKETTEAMESFQ-------TRDAVQEafyellnDLR-WYLRRV----- 696
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 729 knedaldREAAYATLYEALVLVATLAAPFTPFLAEVLWQnlvrsvRLEAKESVHLADWPEADPALADEALVAQMRAVLKV 808
Cdd:PRK12300 697 -------GEANNKVLREVLEIWIRLLAPFTPHLAEELWH------KLGGEGFVSLEKWPEPDESKIDEEAELAEEYVKRL 763
|
..
1JZQ_A 809 VD 810
Cdd:PRK12300 764 IE 765
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
304-815 |
5.75e-36 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 146.35 E-value: 5.75e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 304 VLADYvsqedGTGIVHQAPAFGAEDLETARVYGLPLLKTVD---------------EEGKLLV-EPFKGLYFREANRAIL 367
Cdd:COG0495 328 VLMDY-----GTGAVMAVPAHDQRDFEFAKKYGLPIKQVIApedgddpdileeaytGDGVLINsGEFDGLDSEEAKEAII 402
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 368 RDLRGRGLlfkeesylhsyphcwrcstplmyyateswfikntlfkdelirnnqeihwvpphikegryGEWLKN--LVDWA 445
Cdd:COG0495 403 EWLEEKGL-----------------------------------------------------------GKRKVNyrLRDWL 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 446 LSRNRYWGTPLPIWVCQACGkeeaigsfqelkaraTKPLPE---P--------FDP-------HRPyvDQVELAC-ACGG 506
Cdd:COG0495 424 ISRQRYWGEPIPIIHCEDCG---------------VVPVPEdqlPvelpedvdFDPtggsplaRAP--EWVNVTCpKCGG 486
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 507 TMRRVPYVIDVWYDSG--AMPFASLHY---PFEHEEVfRESFPADFIAEGIDQT-------RGWFNSLHQLGVMlfgSIA 574
Cdd:COG0495 487 PARRETDTMDTFVDSSwyYLRYTDPHNdeaPFDPEAA-NYWLPVDQYIGGIEHAilhllyaRFFTKVLRDLGLV---SFD 562
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 575 --FKNVICHGLILD--------EKGQKMSKSKGNVVDPWDIIRKFGADALRWYIYVSAPPEAD-----------RRFgpn 633
Cdd:COG0495 563 epFKRLLTQGMVLEvgkdgvviGGIEKMSKSKGNVVDPDEIIEKYGADTLRLFEMFAGPPERDlewsdsgvegaYRF--- 639
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 634 LVRetvrdyfltlwnVYSFFVTYANLDRPDLKNPPPPEKrpEMDRwllaRMQDLIQRVTEALEAYDPTTSARALRDFV-- 711
Cdd:COG0495 640 LNR------------VWRLVVDEAEALKLDVADLSEADK--ELRR----ALHKTIKKVTEDIERLRFNTAIAALMELVna 701
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 712 VEDLSQwyvrrnrrrFWKNEDALDREAAyatlyEALVLvatLAAPFTPFLAEVLWQnlvrsvRLEAKESVHLADWPEADP 791
Cdd:COG0495 702 LYKAKD---------SGEADRAVLREAL-----ETLVL---LLAPFAPHIAEELWE------RLGHEGSVADAPWPEADE 758
|
570 580 590
....*....|....*....|....*....|..
1JZQ_A 792 AL--ADEA-LVAQ----MRAVLKV-VDLARAA 815
Cdd:COG0495 759 AAlvEDEVtIVVQvngkVRGKIEVpADASKEE 790
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
677-821 |
3.15e-33 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 124.82 E-value: 3.15e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 677 DRWLLARMQDLIQRVTEALEAYDPTTSARALRDFVVEDLSQWYVRRNRRRFWKNEDAldrEAAYATLYEALVLVATLAAP 756
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPD---SRAQTTLYEVLETLLRLLAP 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
1JZQ_A 757 FTPFLAEVLWQNlvrsvrleakESVHLADWPEaDPALADEALVAQMRAVLKVVDLARAARAKSGV 821
Cdd:pfam08264 78 FMPFITEELWQK----------ESIHLAPWPE-DAELEEAELEEAFELRQEIVQAIRKLRSELKI 131
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
632-758 |
1.47e-31 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 119.15 E-value: 1.47e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 632 PNLVRETvRDYFLTLWNVYSFFVTYANLDRPDLKNppppEKRPEMDRWLLARMQDLIQRVTEALEAYDPTTSARALRDFV 711
Cdd:cd07375 1 EERLKQA-RAFLNRLYRLLSFFRKALGGTQPKWDN----ELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFT 75
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
1JZQ_A 712 VEDlsQWYVRRNRRRFWKNEdalDREAAYATLYEALVLVATLAAPFT 758
Cdd:cd07375 76 NEL--NWYLDELKPALQTEE---LREAVLAVLRAALVVLTKLLAPFT 117
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
10-799 |
2.35e-30 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 128.79 E-value: 2.35e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 10 FPKLEEEVLAFWKREKIFQKSVENRKGGPRYTVYEG-P-PTANGLpHVGHAQARSYKDLFPRYKTMRGYYAPRRAGWDTH 87
Cdd:PLN02563 82 FHEIEPKWQRYWEENRTFRTPDDVDTSKPKFYVLDMfPyPSGAGL-HVGHPEGYTATDILARYKRMQGYNVLHPMGWDAF 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 88 GLPVE---LEVEKKLGLKSKREieaygIERFNQACRESVFTYekeweafteriaywvDLEDAYATLEPTYIESIWWSLKN 164
Cdd:PLN02563 161 GLPAEqyaIETGTHPKITTLKN-----IARFRSQLKSLGFSY---------------DWDREISTTEPEYYKWTQWIFLQ 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 165 LFDRGLLYRDHKVVPYCPRCGTPLSSHEVALGYKEIQDPSVyVRFPLKE---------------------P--------- 214
Cdd:PLN02563 221 LLKRGLAYQAEVPVNWCPALGTVLANEEVVDGLSERGGHPV-IRKPMRQwmlkitayadrlledlddldwPesikemqrn 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 215 ---KKLGLE-------------KASLLIWTTTPWTLPGNVAAAVHPEYTYAAFQVGDE--ALILE--EGLGRKLLGEGTQ 274
Cdd:PLN02563 300 wigRSEGAEldfsvldgegkerDEKITVYTTRPDTLFGATYLVVAPEHPLLSSLTTAEqkEAVEEyvDAASRKSDLERTE 379
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 275 VLKTFPGKALEGLPYTPPYPQALEkgyfVVLADYVSQEDGTGIVHQAPAFGAEDLETARVYGLPLlktvdeegKLLVEPF 354
Cdd:PLN02563 380 LQKEKTGVFTGSYAINPATGEAIP----IWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPI--------KWVVKPA 447
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 355 KGlyfreanrailrDLRGRGLLFKEESylhsyphcwrcstpLMYYATESWFIKNTLFKDEliRNNQEIHWVpphiKEGRY 434
Cdd:PLN02563 448 DG------------NEDDAEKAYTGEG--------------VIVNSSSSGLDINGLSSKE--AAKKVIEWL----EETGN 495
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 435 GEWLKN--LVDWALSRNRYWGTPLPIWVCQACGKEEAIgSFQELKARatkpLPE---------PFDPHRPYVDQVELACA 503
Cdd:PLN02563 496 GKKKVNykLRDWLFARQRYWGEPIPVVFLEDSGEPVPV-PESDLPLT----LPElddftptgtGEPPLAKAVSWVNTVDP 570
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 504 CGGT-MRRVPYVIDVWYDSGAMPFASLHYPFEHE----EVFRESFPADFIAEGIDQ-------TRGWFNSLHQLGVMLFG 571
Cdd:PLN02563 571 SSGKpARRETNTMPQWAGSCWYYLRFMDPKNSNAlvdkEKEKYWMPVDLYVGGAEHavlhllyARFWHKVLYDIGVVSTK 650
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 572 SiAFKNVICHGLILDE------------------------------------------------------KGQKMSKSKG 597
Cdd:PLN02563 651 E-PFQCLVNQGMILGEveytafkdsdgeyvsadtadrlgelqqekipeekviksgdsfvlkddpsirliaRAHKMSKSRG 729
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 598 NVVDPWDIIRKFGADALRWYIYVSAPPEADRRFGPNLVRETVRdyFLTlwNVYSFFVTYANLDRPDLKNPPPPEKrpEMD 677
Cdd:PLN02563 730 NVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWSTSGVEGVHR--FLG--RTWRLVVGAPLPDGSFRDGTVVTDE--EPS 803
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 678 RWLLARMQDLIQRVTEALEAYDPTTSARALRDFVvedlsqwyvrrNRRRFWKNedaLDREAAyatlyEALVLvatLAAPF 757
Cdd:PLN02563 804 LEQLRLLHKCIAKVTEEIESTRFNTAISAMMEFT-----------NAAYKWDK---VPREAI-----EPFVL---LLSPY 861
|
890 900 910 920
....*....|....*....|....*....|....*....|..
1JZQ_A 758 TPFLAEVLWQnlvrsvRLEAKESVHLADWPEADPALADEALV 799
Cdd:PLN02563 862 APHLAEELWF------RLGHSNSLAYEPWPEANPSYLVDDTV 897
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
643-769 |
6.38e-24 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 98.01 E-value: 6.38e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 643 FLT-LWNVYSFFVTyaNLDRPDLKNPPPPEKRPeMDRWLLARMQDLIQRVTEALEAYDPTTSARALRDFVVEDLSQWYVR 721
Cdd:cd07962 12 FCNkLWNAARFVLM--NLEDDDEPEEDPESLSL-ADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFWNDFCDWYLE 88
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
1JZQ_A 722 RNRRRFWkNEDALDREAAYATLYEALVLVATLAAPFTPFLAEVLWQNL 769
Cdd:cd07962 89 LVKPRLY-GEDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
665-810 |
1.10e-23 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 98.75 E-value: 1.10e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 665 KNPPPPEKRPEMDRWLLARMQDLIQRVTEALEAYDPTTSARALRDFVVEDLSQWY--VRRNRRRFWKnEDALDREAAYAT 742
Cdd:cd07960 34 KDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCTVDLSAFYldIIKDRLYCDA-KDSLERRSAQTV 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
1JZQ_A 743 LYEALVLVATLAAPFTPFLAEVLWQNLVRSvrlEAKESVHLADWPEADPALADEALVAQMRAVLKVVD 810
Cdd:cd07960 113 LYHILDALLKLLAPILPFTAEEVWEHLPGE---KKEESVFLEDWPELPEEWKDEELEEKWEKLLALRD 177
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
387-769 |
5.62e-21 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 97.26 E-value: 5.62e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 387 PHCWRCSTPLMYYATESWFIKNTLFKD---ELIRNNQEihWVPPhikEGRYGE---WLKN-LVDWALSRNRY-WGTPLPi 458
Cdd:PRK11893 142 YRCPPTGAPVEWVEEESYFFRLSKYQDkllELYEANPD--FIQP---ASRRNEvisFVKSgLKDLSISRTNFdWGIPVP- 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 459 wvcqacgkeeaigsfqelkaratkplpepFDP-HRPYVdqvelacacggtmrrvpyvidvWYDSGAMPFASLHYPFEHEE 537
Cdd:PRK11893 216 -----------------------------GDPkHVIYV----------------------WFDALTNYLTALGYPDDEEL 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 538 V---FRESFPAD--FIaeGIDQTR----GWFNSLHQLGVMLFgsiafKNVICHGLILDEkGQKMSKSKGNVVDPWDIIRK 608
Cdd:PRK11893 245 LaelFNKYWPADvhLI--GKDILRfhavYWPAFLMAAGLPLP-----KRVFAHGFLTLD-GEKMSKSLGNVIDPFDLVDE 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 609 FGADALRWYIYVSAPPEADRRFgpnlvretVRDYFLTLWNvySFFV-TYANL-DR---PDLKN----PPPPEKRPEMDRW 679
Cdd:PRK11893 317 YGVDAVRYFLLREIPFGQDGDF--------SREAFINRIN--ADLAnDLGNLaQRtlsMIAKNfdgkVPEPGALTEADEA 386
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 680 LLARMQDLIQRVTEALEAYDPTTSARALRDfVVEDLSQWYvrrNRRRFW---KNEDALDREAAYaTLYEALVLVATLAAP 756
Cdd:PRK11893 387 LLEAAAALLERVRAAMDNLAFDKALEAILA-LVRAANKYI---DEQAPWslaKTDPERLATVLY-TLLEVLRGIAVLLQP 461
|
410
....*....|...
1JZQ_A 757 FTPFLAEVLWQNL 769
Cdd:PRK11893 462 VMPELAAKILDQL 474
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
387-769 |
5.74e-21 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 97.49 E-value: 5.74e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 387 PHCWRCSTPLMYYATESWFIKNTLFKDEL---IRNNqeihwvpPHIKEGRYGE---WLKN-LVDWALSRNRYWGTPLP-- 457
Cdd:COG0143 169 PRSAISGAPPELREEEHYFFRLSKYQDRLlewIEEN-------PDIQPEVRNEvlsWLKEgLQDLSISRDFDWGIPVPgd 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 458 ------IWVcqacgkeEA----IGSFQELKARatKPLPEPFDphrpyvdqvelacacggtmrrvpyviDVWYDSGAmpfA 527
Cdd:COG0143 242 pgkvfyVWF-------DAligyISATKGYADD--RGLPEDFE--------------------------KYWPAPDT---E 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 528 SLHY------PFeHEeVFresFPAdfiaegidqtrgwfnslhqlgvMLFGS--IAFKNVICHGLILDEkGQKMSKSKGNV 599
Cdd:COG0143 284 LVHFigkdiiRF-HA-II---WPA----------------------MLMAAglPLPKKVFAHGFLTVE-GEKMSKSRGNV 335
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 600 VDPWDIIRKFGADALRWYIYVSAPPEADRRFGP----------------NLVRETVrdyfltlwnvySFFVTYANldrpd 663
Cdd:COG0143 336 IDPDDLLDRYGPDALRYYLLREVPFGQDGDFSWedfvarvnsdlandlgNLASRTL-----------SMIHKYFD----- 399
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 664 lKNPPPPEKRPEMDRWLLARMQDLIQRVTEALEAYDPTTSARALRDFvvedlsqwyVRRNRRRF-----WKNEDALDREA 738
Cdd:COG0143 400 -GKVPEPGELTEADEELLAEAEAALEEVAEAMEAFEFRKALEEIMAL---------ARAANKYIdetapWKLAKDEDPER 469
|
410 420 430
....*....|....*....|....*....|....
1JZQ_A 739 AYATLY---EALVLVATLAAPFTPFLAEVLWQNL 769
Cdd:COG0143 470 LATVLYtllEALRILAILLKPFLPETAEKILEQL 503
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
360-630 |
1.29e-18 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 87.59 E-value: 1.29e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 360 REANRAILRDLRGRGLLFKEEsylHSYPHCWRCSTPLMYY-ATESWFIKNTLFKDEL---IRNNQEIHWVPPHIKEGRyg 435
Cdd:cd00814 98 KEIVQEFFKKLYENGYIYEGE---YEGLYCVSCERFLPEWrEEEHYFFRLSKFQDRLlewLEKNPDFIWPENARNEVL-- 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 436 EWLKN-LVDWALSR-NRYWGTPLPiwvcqacgkeeaigsfqelkaratkplpepFDPhrpyvDQVelacacggtmrrvpy 513
Cdd:cd00814 173 SWLKEgLKDLSITRdLFDWGIPVP------------------------------LDP-----GKV--------------- 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 514 vIDVWYDSgamPF---ASLHYPFEH---EEVFRESFPAD--FIaeGIDQTRG----WFNSLHQLGVMLFgsiafKNVICH 581
Cdd:cd00814 203 -IYVWFDA---LIgyiSATGYYNEEwgnSWWWKDGWPELvhFI--GKDIIRFhaiyWPAMLLGAGLPLP-----TRIVAH 271
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
1JZQ_A 582 GLILDEkGQKMSKSKGNVVDPWDIIRKFGADALRWYIYVSAPPEADRRF 630
Cdd:cd00814 272 GYLTVE-GKKMSKSRGNVVDPDDLLERYGADALRYYLLRERPEGKDSDF 319
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
387-639 |
3.79e-18 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 88.59 E-value: 3.79e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 387 PHCWRCSTPLMYYATESWFIKNTLFKDEL---IRNNQEIHWVPPHIKEgRYGEWLKN-LVDWALSR-NRYWGTPLPiwvc 461
Cdd:TIGR00398 167 PRCKICGAKPELRDSEHYFFRLSAFEKELeewIRKNPESGSPASNVKN-KAQNWLKGgLKDLAITRdLVYWGIPVP---- 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 462 qacgkeeaigsfqelkaratkplpepFDPHRpyvdqvelacacggtmrrvpyVIDVWYDSgamPF---ASLHYPFEHEEV 538
Cdd:TIGR00398 242 --------------------------NDPNK---------------------VVYVWFDA---LIgyiSSLGILSGDTED 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 539 FRESFPADFIAE-----GIDQTRG----WFNSLHQLGVMLFgsiafKNVICHGLILDEkGQKMSKSKGNVVDPWDIIRKF 609
Cdd:TIGR00398 272 WKKWWNNDEDAElihfiGKDIVRFhtiyWPAMLMGLGLPLP-----TQVFSHGYLTVE-GGKMSKSLGNVVDPSDLLARF 345
|
250 260 270
....*....|....*....|....*....|
1JZQ_A 610 GADALRWYIYVSAPPEADRRFGPNLVRETV 639
Cdd:TIGR00398 346 GADILRYYLLKERPLGKDGDFSWEDFVERV 375
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
404-627 |
7.10e-18 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 85.38 E-value: 7.10e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 404 WFIK--NTLFKDELIRNNQEIHWVPPHIKEGrygewLKNLVDwaLSRNRYWGTPLPI-WVcqacgkeeaIGSFQE---LK 477
Cdd:cd00812 132 WFLKysETEWKEKLLKDLEKLDGWPEEVRAM-----QENWIG--CSRQRYWGTPIPWtDT---------MESLSDstwYY 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 478 ARATkplpepfDPHRPYVDQVELACAcggtMRRVP---YVIDvWYDSGAmPFASLH---YPFEHEEVFRESFPADFiaeg 551
Cdd:cd00812 196 ARYT-------DAHNLEQPYEGDLEF----DREEFeywYPVD-IYIGGK-EHAPNHllySRFNHKALFDEGLVTDE---- 258
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
1JZQ_A 552 idqtrgWFnslhqlgvmlfgsiafKNVICHGLILDEkGQKMSKSKGNVVDPWDIIRKFGADALRWYIYVSAPPEAD 627
Cdd:cd00812 259 ------PP----------------KGLIVQGMVLLE-GEKMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPDAD 311
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
513-769 |
2.15e-16 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 83.70 E-value: 2.15e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 513 YVIDVWYDsgampfA------SLHYPFEHEEVFRESFPADFIAEGIDQTRgwFNS------LHQLGVMLFgsiafKNVIC 580
Cdd:PRK12267 223 HVVYVWID------AllnyitALGYGSDDDELFKKFWPADVHLVGKDILR--FHAiywpimLMALGLPLP-----KKVFA 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 581 HGLILdEKGQKMSKSKGNVVDPWDIIRKFGADALRWYIYVSAPPEADRRFGP----------------NLVRETVrdyfl 644
Cdd:PRK12267 290 HGWWL-MKDGKMSKSKGNVVDPEELVDRYGLDALRYYLLREVPFGSDGDFSPealverinsdlandlgNLLNRTV----- 363
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 645 TLWNVYSFFVTyanldrpdlknpPPPEKRPEMDRWLLARMQDLIQRVTEALEAYDPTtsaRALrdfvvEDLsqW-YVRRN 723
Cdd:PRK12267 364 AMINKYFDGEI------------PAPGNVTEFDEELIALAEETLKNYEELMEELQFS---RAL-----EEV--WkLISRA 421
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
1JZQ_A 724 RRRF-----W---KNEDALDR-EAAYATLYEALVLVATLAAPFTPFLAEVLWQNL 769
Cdd:PRK12267 422 NKYIdetapWvlaKDEGKKERlATVMYHLAESLRKVAVLLSPFMPETSKKIFEQL 476
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
387-630 |
4.39e-14 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 75.02 E-value: 4.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 387 PHCWRCSTPLMYYATESWFIKNTLFKDELIrnnqeiHWVPPHIKEGRYG------EWLKN-LVDWALSRNRYWGTPLPiw 459
Cdd:pfam09334 167 PKCVICGTTPEVKETEHYFFDLSKFQDKLR------EWIEENNPEWPENvknmvlEWLKEgLKDRAISRDLDWGIPVP-- 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 460 vcQACGKeeaigsfqelkaratkplpepfdphrpyvdqvelacacggtmrrvpyVIDVWYDSGAMPFASLHYPFEHEEVF 539
Cdd:pfam09334 239 --GAEGK-----------------------------------------------VFYVWLDAPIGYISATKELSGNEEKW 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 540 RESFPAD-------FIaeGIDQTRgwFNSLHQLGVMLFGSIAF-KNVICHGLILDEkGQKMSKSKGNVVDPWDIIRKFGA 611
Cdd:pfam09334 270 KEWWPNDpdtelvhFI--GKDIIY--FHTIFWPAMLLGAGYRLpTTVFAHGYLTYE-GGKMSKSRGNVVWPSEALDRFPP 344
|
250
....*....|....*....
1JZQ_A 612 DALRWYIYVSAPPEADRRF 630
Cdd:pfam09334 345 DALRYYLARNRPETKDTDF 363
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
577-766 |
2.62e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 60.94 E-value: 2.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 577 NVICHG-LILDekGQKMSKSKGNVVDPWDIIRKFGADALRWYIYVSAPpeadrrfgpnlvrETVRDYFLT---------- 645
Cdd:PRK00133 316 NVFAHGfLTVE--GAKMSKSRGTFIWARTYLDHLDPDYLRYYLAAKLP-------------ETIDDLDFNwedfqqrvns 380
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 646 -LWNVYSFFV------TYANLD-RPDLKnppppekrpEMDRWLLARMQDLIQRVTEALEAYDpttSARALRDFVveDLSQ 717
Cdd:PRK00133 381 eLVGKVVNFAsrtagfINKRFDgKLPDA---------LADPELLEEFEAAAEKIAEAYEARE---FRKALREIM--ALAD 446
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
1JZQ_A 718 W---YVRRNRRrfWKNEDAlDREAAYATLYEALVLVATLA---APFTPFLAEVLW 766
Cdd:PRK00133 447 FankYVDDNEP--WKLAKQ-DGERLQAVCSVGLNLFRALAiylKPVLPELAERAE 498
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
47-181 |
1.43e-07 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 54.18 E-value: 1.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 47 PTANGLPHVGHAQARSYKDLFPRYKTMRGYYAPRRAGWDTHGLPvelevekklglkskreIEAYGIERfNQACRESVFTY 126
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLP----------------AENAAIKI-GRDPEDWTEYN 71
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
1JZQ_A 127 EKEWEAFTERIAYWVDLEDAYATLEPTYIESIWWSLKNLFDRGLLYRDHKVVPYC 181
Cdd:cd00812 72 IKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC 126
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
47-189 |
1.49e-07 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 54.07 E-value: 1.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 47 PTANGLPHVGHaqARSY--KDLFPRYKTMRGYYAPRRAGWDTHGLPVELEVEkKLGLkSKREIeaygIERFNQAcresvf 124
Cdd:cd00814 9 PYVNGVPHLGH--LYGTvlADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAE-EEGV-TPQEL----CDKYHEI------ 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
1JZQ_A 125 tYEKEWEAFteRIAYwvdleDAYA-TLEPTYIESIWWSLKNLFDRGLLYRDHKVVPYCPRCGTPLS 189
Cdd:cd00814 75 -FKDLFKWL--NISF-----DYFIrTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP 132
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
663-769 |
3.48e-07 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 49.51 E-value: 3.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 663 DLKNPPPPEKRPemDRWLLARMQDLIQRVTEALEAYDpTTSA--RALRDFvVEDLsQWYvrRNRRRFWKNEDALDReaay 740
Cdd:cd07959 25 ETEGELEELTFI--DRWLLSRLNRLIKETTEAYENMQ-FREAlkEGLYEL-QNDL-DWY--RERGGAGMNKDLLRR---- 93
|
90 100
....*....|....*....|....*....
1JZQ_A 741 atLYEALVLvatLAAPFTPFLAEVLWQNL 769
Cdd:cd07959 94 --FIEVWTR---LLAPFAPHLAEEIWHEL 117
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
667-769 |
3.92e-07 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 49.80 E-value: 3.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 667 PPPPEKRPEMDRWLLARMQDLIQRVTEALEAYDPttsARALRdfVVEDLSQW---YVrrNRRRFWKNEDALDREAAYATL 743
Cdd:cd07957 28 VPEFGGLTEEDEELLEEAEELLEEVAEAMEELEF---RKALE--EIMELARAankYI--DETAPWKLAKEEDPERLATVL 100
|
90 100
....*....|....*....|....*....
1JZQ_A 744 Y---EALVLVATLAAPFTPFLAEVLWQNL 769
Cdd:cd07957 101 YvllELLRILAILLSPFMPETAEKILDQL 129
|
|
| lysK |
PRK00750 |
lysyl-tRNA synthetase; Reviewed |
583-643 |
1.10e-05 |
|
lysyl-tRNA synthetase; Reviewed
Pssm-ID: 234829 [Multi-domain] Cd Length: 510 Bit Score: 48.65 E-value: 1.10e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
1JZQ_A 583 LILDEKGQKMSKSKGNVVDPWDIIRKFGADALRWYIYVSAPPEADRRFG--PNLVRE---TVRDYF 643
Cdd:PRK00750 272 LFLDKKGEKISKSKGNVITIEDWLEYAPPESLRLFMFARPKPAKRLDFDviPKLVDEydrFERKYF 337
|
|
| tRNA-synt_1f |
pfam01921 |
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from ... |
583-646 |
1.71e-05 |
|
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from prokaryotes.
Pssm-ID: 396483 Cd Length: 357 Bit Score: 48.03 E-value: 1.71e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
1JZQ_A 583 LILDEKGQKMSKSKGNVVDPWDIIRKFGADALRWYIYvSAPPEADRRFG----PNLVRE---TVRDYFLTL 646
Cdd:pfam01921 271 LILLKGGGKMSSSKGNVITPEDWLEYAPPESLRFLMF-RTKPKKAKDLDfdviPRLVDEydrLERIYFAKQ 340
|
|
| LysS |
COG1384 |
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA ... |
583-643 |
4.25e-05 |
|
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA synthetase, class I is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440994 [Multi-domain] Cd Length: 525 Bit Score: 47.11 E-value: 4.25e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
1JZQ_A 583 LILDEKGQKMSKSKGNVVDPWDIIRKFGADALRWYIYvsAPPEADRRFGPNLVRETVRDYF 643
Cdd:COG1384 279 LFLDENGEKISKSKGNGLTVEEWLEYAEPESLRYFMF--RKPKKAKDLDFDVIPKLVDEYD 337
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
557-617 |
6.65e-05 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 46.63 E-value: 6.65e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
1JZQ_A 557 GWFNSLHQLG--VMLFGSIAF------------KNVICHGLiLDEKGQKMSKSKGNVVDPWDIIRKFGADALRWY 617
Cdd:PLN02224 319 GWPASLHLIGkdILRFHAVYWpamlmsaglelpKMVFGHGF-LTKDGMKMGKSLGNTLEPFELVQKFGPDAVRYF 392
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
588-619 |
1.06e-04 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 44.11 E-value: 1.06e-04
10 20 30
....*....|....*....|....*....|..
1JZQ_A 588 KGQKMSKSKGNVVDPWDIIRKFGADALRWYIY 619
Cdd:cd00672 171 DGEKMSKSLGNFITVRDALKKYDPEVLRLALL 202
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
589-618 |
3.75e-04 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 43.94 E-value: 3.75e-04
10 20 30
....*....|....*....|....*....|
1JZQ_A 589 GQKMSKSKGNVVDPWDIIRKFGADALRWYI 618
Cdd:COG0215 263 GEKMSKSLGNFFTVRDLLKKYDPEVLRFFL 292
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
649-769 |
3.75e-04 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 40.67 E-value: 3.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 649 VYSFFVTYANldrpDLKNPPPPEKRPEMDRWLLARMQDLIQRVTEALEAYDPTTSARALRDFVVEdLSQWyvrrnrrrfw 728
Cdd:cd07958 16 VWRLVTELAE----ALAAPAAAAELSEEDKELRRKLHKTIKKVTEDIERLRFNTAIAALMELVNA-LYKY---------- 80
|
90 100 110 120
....*....|....*....|....*....|....*....|.
1JZQ_A 729 KNEDALDReaayATLYEALVLVATLAAPFTPFLAEVLWQNL 769
Cdd:cd07958 81 KKKDAQHA----AVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| TyrRS_core |
cd00805 |
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) ... |
551-624 |
1.02e-03 |
|
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) catalytic core domain. TyrRS is a homodimer which attaches Tyr to the appropriate tRNA. TyrRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formationof the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173902 [Multi-domain] Cd Length: 269 Bit Score: 41.82 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JZQ_A 551 GIDQtrgWFNslHQLGVMLFGSIAFKNVIC--HGLILDEKGQKMSKSKGNVV------DPWDIIRKF----GADALRWYI 618
Cdd:cd00805 158 GSDQ---RGN--ITLGRDLIRKLGYKKVVGltTPLLTGLDGGKMSKSEGNAIwdpvldSPYDVYQKIrnafDPDVLEFLK 232
|
....*.
1JZQ_A 619 YVSAPP 624
Cdd:cd00805 233 LFTFLD 238
|
|
| LysRS_core_class_I |
cd00674 |
catalytic core domain of class I lysyl tRNA synthetase; Class I lysyl tRNA synthetase (LysRS) ... |
579-636 |
1.99e-03 |
|
catalytic core domain of class I lysyl tRNA synthetase; Class I lysyl tRNA synthetase (LysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The class I LysRS is found only in archaea and some bacteria and has evolved separately from class II LysRS, as the two do not share structural or sequence similarity.
Pssm-ID: 173900 [Multi-domain] Cd Length: 353 Bit Score: 41.16 E-value: 1.99e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
1JZQ_A 579 ICHGLILDEKGQKMSKSKGNVVDPWDIIRKFGADALRWYIYVSAPPEADRRFGPNLVR 636
Cdd:cd00674 263 VMYEFIGLKGGGKMSSSKGNVITPSDWLEVAPPEVLRYLYARRKNPEKHIGFDLDILR 320
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
588-619 |
5.39e-03 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 39.66 E-value: 5.39e-03
10 20 30
....*....|....*....|....*....|..
1JZQ_A 588 KGQKMSKSKGNVVDPWDIIRKFGADALRWYIY 619
Cdd:pfam01406 250 DGEKMSKSLGNFFTIRDVLKRYDPEILRYFLL 281
|
|
| |
