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Conserved domains on  [gi|230206|pdb|1OVO|B]
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Chain B, OVOMUCOID THIRD DOMAIN

Protein Classification

Kazal-type serine protease inhibitor family protein( domain architecture ID 10441216)

Kazal-type serine protease inhibitor family protein may function as a serine protease inhibitor

CATH:  3.30.60.30
Gene Ontology:  GO:0004867|GO:0005576
PubMed:  19995574|12051857
SCOP:  4003413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Kazal_1 pfam00050
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
 8-56 7.29e-18

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides. Alignment also includes a single domain from transporters in the OATP/PGT family.


:

Pssm-ID: 395004  Cd Length: 49  Bit Score: 68.47  E-value: 7.29e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
1OVO_B         8 CSEYPKPACPKDYRPVCGSDNKTYSNKCNFCNAVVESNGTLTLNHFGKC 56
Cdd:pfam00050  1 CSDYPSGACPRIYDPVCGTDGKTYSNECLFCAENGKRGTNLHKVHDGEC 49
 
Name Accession Description Interval E-value
Kazal_1 pfam00050
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
 8-56 7.29e-18

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides. Alignment also includes a single domain from transporters in the OATP/PGT family.


Pssm-ID: 395004  Cd Length: 49  Bit Score: 68.47  E-value: 7.29e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
1OVO_B         8 CSEYPKPACPKDYRPVCGSDNKTYSNKCNFCNAVVESNGTLTLNHFGKC 56
Cdd:pfam00050  1 CSDYPSGACPRIYDPVCGTDGKTYSNECLFCAENGKRGTNLHKVHDGEC 49
KAZAL smart00280
Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...
 7-56 2.46e-13

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.


Pssm-ID: 197624  Cd Length: 46  Bit Score: 56.92  E-value: 2.46e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
1OVO_B          7 DCSEypkpACPKDYRPVCGSDNKTYSNKCNFCNAVVESNGTLTLNHFGKC 56
Cdd:smart00280  1 DCPE----ACPREYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46
KAZAL_PSTI cd01327
Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the ...
 13-56 3.40e-10

Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the superfamily of kazal-type proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238648  Cd Length: 45  Bit Score: 48.82  E-value: 3.40e-10
                       10        20        30        40
               ....*....|....*....|....*....|....*....|....
1OVO_B      13 KPACPKDYRPVCGSDNKTYSNKCNFCNAVVESNGTLTLNHFGKC 56
Cdd:cd01327  2 VFGCPKDYDPVCGTDGVTYSNECLLCAENLKRQTNIRIKHDGEC 45
 
Name Accession Description Interval E-value
Kazal_1 pfam00050
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
 8-56 7.29e-18

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides. Alignment also includes a single domain from transporters in the OATP/PGT family.


Pssm-ID: 395004  Cd Length: 49  Bit Score: 68.47  E-value: 7.29e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
1OVO_B         8 CSEYPKPACPKDYRPVCGSDNKTYSNKCNFCNAVVESNGTLTLNHFGKC 56
Cdd:pfam00050  1 CSDYPSGACPRIYDPVCGTDGKTYSNECLFCAENGKRGTNLHKVHDGEC 49
KAZAL smart00280
Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...
 7-56 2.46e-13

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.


Pssm-ID: 197624  Cd Length: 46  Bit Score: 56.92  E-value: 2.46e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
1OVO_B          7 DCSEypkpACPKDYRPVCGSDNKTYSNKCNFCNAVVESNGTLTLNHFGKC 56
Cdd:smart00280  1 DCPE----ACPREYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46
KAZAL_PSTI cd01327
Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the ...
 13-56 3.40e-10

Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the superfamily of kazal-type proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238648  Cd Length: 45  Bit Score: 48.82  E-value: 3.40e-10
                       10        20        30        40
               ....*....|....*....|....*....|....*....|....
1OVO_B      13 KPACPKDYRPVCGSDNKTYSNKCNFCNAVVESNGTLTLNHFGKC 56
Cdd:cd01327  2 VFGCPKDYDPVCGTDGVTYSNECLLCAENLKRQTNIRIKHDGEC 45
KAZAL_FS cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...
 16-56 3.82e-10

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD.


Pssm-ID: 238052 [Multi-domain]  Cd Length: 41  Bit Score: 48.81  E-value: 3.82e-10
                       10        20        30        40
               ....*....|....*....|....*....|....*....|.
1OVO_B      16 CPKDYRPVCGSDNKTYSNKCNFCNAVVESNGTLTLNHFGKC 56
Cdd:cd00104  1 CPKEYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 5-56 4.69e-03

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 32.60  E-value: 4.69e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
1OVO_B        5 SVDCSeypkpaCPKD-YRPVCGSDNKTYSNKCnF--CNAVVESNGTLTlnhFGKC 56
Cdd:cd17336 313 NSDCN------CSDSsFSPVCGSDGITYFSPC-HagCTSSDAGNGTKT---YSNC 357
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
 15-53 6.10e-03

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 30.92  E-value: 6.10e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
1OVO_B        15 ACPKD-YRPVCGSDNKTYSNKCNFCNAVVESNGTLTLNHF 53
Cdd:pfam07648  5 QCPKTeYEPVCGSDGVTYPSPCALCAAGCKLGKEVKEEKV 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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