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Conserved domains on  [gi|71042326|pdb|1ZIW|A]
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Chain A, Toll-like receptor 3

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
10-283 4.77e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 4.77e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       10 DCSHLKLTQVPDDLP--TNITVLNLTHNQLRRLPAAnFTRYSQLTSLDVGFNTISKLEPELcQKLPMLKVLNLQHNELSQ 87
Cdd:COG4886 119 DLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQITD 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       88 LSDkTFAFCTNLTELHLMSNSIQKIkNNPFVKQKNLITLDLSHNGLSStkLGTQVQLENLQELLLSNNKIQALKSEeldi 167
Cdd:COG4886 197 LPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTD--LPELGNLTNLEELDLSNNQLTDLPPL---- 268

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      168 FANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKW 247
Cdd:COG4886 269 ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLA 348

                       250       260       270
                ....*....|....*....|....*....|....*.
1ZIW_A      248 TNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNN 283
Cdd:COG4886 349 LLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLAL 384
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 328-514 2.61e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 2.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      328 LKCLEHLNMEDNDIPGIKSnmFTGLINLKYLSL-SNSFTSLRTLtnETFVSLAHsplhiLNLTKNKISKIESdaFSWLGH 406
Cdd:cd21340   1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLyDNKITKIENL--EFLTNLTH-----LYLQNNQIEKIEN--LENLVN 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      407 LEVLDLGLNEIgQELTGQEwrGLENIFEIYLSY------NKYLQLTRNSFALVPSLQRLMLRRVALknvdSSPSPFQPLR 480
Cdd:cd21340  70 LKKLYLGGNRI-SVVEGLE--NLTNLEELHIENqrlppgEKLTFDPRSLAALSNSLRVLNISGNNI----DSLEPLAPLR 142

                       170       180       190
                ....*....|....*....|....*....|....*.
1ZIW_A      481 NLTILDLS--NNNIANINDDMLEGLEKLEILDLQHN 514
Cdd:cd21340 143 NLEQLDASnnQISDLEELLDLLSSWPSLRELDLTGN 178
LRRCT smart00082
Leucine rich repeat C-terminal domain;
619-671 3.71e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.04  E-value: 3.71e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
1ZIW_A         619 NPFDCTCEsIAWFVNWINET-HTNIPElssHYLCNTPPHYHGfPVRLFDTSS--CK 671
Cdd:smart00082   1 NPFICDCE-LRWLLRWLQANeHLQDPV---DLRCASPSSLRG-PLLELLHSEfkCP 51
LRR_8 pfam13855
Leucine rich repeat;
536-596 2.52e-06

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 2.52e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
1ZIW_A        536 SHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLI 596
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 super family cl38440
Leucine rich repeat;
272-341 3.93e-03

Leucine rich repeat;


The actual alignment was detected with superfamily member pfam13855:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 3.93e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A        272 PQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSftkqsislaSLPKIDDFSFQWLKCLEHLNMEDNDI 341
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN---------LLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
10-283 4.77e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 4.77e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       10 DCSHLKLTQVPDDLP--TNITVLNLTHNQLRRLPAAnFTRYSQLTSLDVGFNTISKLEPELcQKLPMLKVLNLQHNELSQ 87
Cdd:COG4886 119 DLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQITD 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       88 LSDkTFAFCTNLTELHLMSNSIQKIkNNPFVKQKNLITLDLSHNGLSStkLGTQVQLENLQELLLSNNKIQALKSEeldi 167
Cdd:COG4886 197 LPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTD--LPELGNLTNLEELDLSNNQLTDLPPL---- 268

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      168 FANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKW 247
Cdd:COG4886 269 ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLA 348

                       250       260       270
                ....*....|....*....|....*....|....*.
1ZIW_A      248 TNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNN 283
Cdd:COG4886 349 LLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLAL 384
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 46-516 5.29e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 66.02  E-value: 5.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A        46 TRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELS-QLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKqkNLI 124
Cdd:PLN00113  66 NNSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIP--NLE 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       125 TLDLSHNGLSStklgtqvqlenlqelllsnnKIQAlkseelDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNN 204
Cdd:PLN00113 144 TLDLSNNMLSG--------------------EIPN------DIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLAS 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       205 VQLgpslTEKLCLELANT-SIRNLSLSNSQLSTTSNTTFLGLkwTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNN 283
Cdd:PLN00113 198 NQL----VGQIPRELGQMkSLKWIYLGYNNLSGEIPYEIGGL--TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNK 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       284 IQHLFSHSLHGLFNVRYLNLKRSFTKQSIslaslPKIddfsFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSL-SN 362
Cdd:PLN00113 272 LSGPIPPSIFSLQKLISLDLSDNSLSGEI-----PEL----VIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLwSN 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       363 SFTSlrtltnETFVSLA-HSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQE--------------------L 421
Cdd:PLN00113 343 KFSG------EIPKNLGkHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEipkslgacrslrrvrlqdnsF 416

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       422 TG---QEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVA-------------LKNVDSS--------PSPFQ 477
Cdd:PLN00113 417 SGelpSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKffgglpdsfgskrLENLDLSrnqfsgavPRKLG 496

                        490       500       510
                 ....*....|....*....|....*....|....*....
1ZIW_A       478 PLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNL 516
Cdd:PLN00113 497 SLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 328-514 2.61e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 2.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      328 LKCLEHLNMEDNDIPGIKSnmFTGLINLKYLSL-SNSFTSLRTLtnETFVSLAHsplhiLNLTKNKISKIESdaFSWLGH 406
Cdd:cd21340   1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLyDNKITKIENL--EFLTNLTH-----LYLQNNQIEKIEN--LENLVN 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      407 LEVLDLGLNEIgQELTGQEwrGLENIFEIYLSY------NKYLQLTRNSFALVPSLQRLMLRRVALknvdSSPSPFQPLR 480
Cdd:cd21340  70 LKKLYLGGNRI-SVVEGLE--NLTNLEELHIENqrlppgEKLTFDPRSLAALSNSLRVLNISGNNI----DSLEPLAPLR 142

                       170       180       190
                ....*....|....*....|....*....|....*.
1ZIW_A      481 NLTILDLS--NNNIANINDDMLEGLEKLEILDLQHN 514
Cdd:cd21340 143 NLEQLDASnnQISDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
248-303 3.21e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.21e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
1ZIW_A        248 TNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNL 303
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDL 56
LRRCT smart00082
Leucine rich repeat C-terminal domain;
619-671 3.71e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.04  E-value: 3.71e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
1ZIW_A         619 NPFDCTCEsIAWFVNWINET-HTNIPElssHYLCNTPPHYHGfPVRLFDTSS--CK 671
Cdd:smart00082   1 NPFICDCE-LRWLLRWLQANeHLQDPV---DLRCASPSSLRG-PLLELLHSEfkCP 51
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 11-181 4.55e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.33  E-value: 4.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       11 CSHLKLTQVPD-DLPTNITVLNLTHNQLRRLPaaNFTRYSQLTSLDVGFNTISKLEPElcQKLPMLKVLNLQHNELSQLS 89
Cdd:cd21340   9 LNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENL--ENLVNLKKLYLGGNRISVVE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       90 DktFAFCTNLTELHLMSNSIQKikNNPFVK--------QKNLITLDLSHNGLSStkLGTQVQLENLQELLLSNNKIQALK 161
Cdd:cd21340  85 G--LENLTNLEELHIENQRLPP--GEKLTFdprslaalSNSLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLE 158

                       170       180
                ....*....|....*....|
1ZIW_A      162 SEELDIFANSSLKKLELSSN 181
Cdd:cd21340 159 ELLDLLSSWPSLRELDLTGN 178
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 590-662 1.10e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.39  E-value: 1.10e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
1ZIW_A         590 NLQKNLITSVEKKVFGPAFrNLTELDMRFNPFDCTCeSIAWFVNWINETHTNI--PELSshyLCNTPPHYHGFPV 662
Cdd:TIGR00864    1 DISNNKISTIEEGICANLC-NLSEIDLSGNPFECDC-GLARLPRWAEEKGVKVrqPEAA---LCAGPGALAGQPL 70
LRR_8 pfam13855
Leucine rich repeat;
536-596 2.52e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 2.52e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
1ZIW_A        536 SHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLI 596
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
383-441 2.70e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 2.70e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
1ZIW_A        383 LHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIgQELTGQEWRGLENIFEIYLSYNK 441
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGAFSGLPSLRYLDLSGNR 60
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 505-621 6.15e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.89  E-value: 6.15e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      505 KLEILDLQHNNL----ARLWKHAnpggpiyfLKGLSHLHILNLESNGFDEIPV----EVFKDLFELKIIDLGLNNLNTLP 576
Cdd:cd00116 166 DLKELNLANNGIgdagIRALAEG--------LKANCNLEVLDLNNNGLTDEGAsalaETLASLKSLEVLNLGDNNLTDAG 237

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
1ZIW_A      577 ASVFNNQV-----SLKSLNLQKNLITSVEKKVFG---PAFRNLTELDMRFNPF 621
Cdd:cd00116 238 AAALASALlspniSLLTLSLSCNDITDDGAKDLAevlAEKESLLELDLRGNKF 290
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 190-524 3.46e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 3.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       190 CFHAIGRLFGLFLNnvqLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNT--TFLGLKWTN---LTMLDLSYNNLNVVG 264
Cdd:PLN00113   9 CPYLIFMLFFLFLN---FSMLHAEELELLLSFKSSINDPLKYLSNWNSSADvcLWQGITCNNssrVVSIDLSGKNISGKI 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       265 NDSFAWLPQLEYFFLEYNNIQHLFSHSLHGL-FNVRYLNLKRSFTKQSISLASLPkiddfsfqwlkCLEHLNMEDNdipg 343
Cdd:PLN00113  86 SSAIFRLPYIQTINLSNNQLSGPIPDDIFTTsSSLRYLNLSNNNFTGSIPRGSIP-----------NLETLDLSNN---- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       344 iksnMFTGLINLKYlslsNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAF-----SWLGHLEVLD---LGLN 415
Cdd:PLN00113 151 ----MLSGEIPNDI----GSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvgqipRELGQMKSLKwiyLGYN 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       416 EIGQELTgQEWRGLENIFEIYLSYN----------------KYLQLTRNSFA-----LVPSLQRLmlrrVALKNVDSSPS 474
Cdd:PLN00113 223 NLSGEIP-YEIGGLTSLNHLDLVYNnltgpipsslgnlknlQYLFLYQNKLSgpippSIFSLQKL----ISLDLSDNSLS 297

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       475 PFQP-----LRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNL-----ARLWKHAN 524
Cdd:PLN00113 298 GEIPelviqLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFsgeipKNLGKHNN 357
LRR_8 pfam13855
Leucine rich repeat;
272-341 3.93e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 3.93e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A        272 PQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSftkqsislaSLPKIDDFSFQWLKCLEHLNMEDNDI 341
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN---------LLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
2-28 4.28e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 35.37  E-value: 4.28e-03
                           10        20
                   ....*....|....*....|....*..
1ZIW_A           2 CTVSHEVADCSHLKLTQVPDDLPTNIT 28
Cdd:smart00013   6 CNCSGTAVDCSGRGLTEVPLDLPPDTT 32
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
10-283 4.77e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 4.77e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       10 DCSHLKLTQVPDDLP--TNITVLNLTHNQLRRLPAAnFTRYSQLTSLDVGFNTISKLEPELcQKLPMLKVLNLQHNELSQ 87
Cdd:COG4886 119 DLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQITD 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       88 LSDkTFAFCTNLTELHLMSNSIQKIkNNPFVKQKNLITLDLSHNGLSStkLGTQVQLENLQELLLSNNKIQALKSEeldi 167
Cdd:COG4886 197 LPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTD--LPELGNLTNLEELDLSNNQLTDLPPL---- 268

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      168 FANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKW 247
Cdd:COG4886 269 ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLA 348

                       250       260       270
                ....*....|....*....|....*....|....*.
1ZIW_A      248 TNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNN 283
Cdd:COG4886 349 LLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLAL 384
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
10-270 1.24e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.35  E-value: 1.24e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       10 DCSHLKLTQVPDDLP--TNITVLNLTHNQLRRLPAAnFTRYSQLTSLDVGFNTISKLEPELCQkLPMLKVLNLQHNELSQ 87
Cdd:COG4886 142 DLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTD 219

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       88 LSDkTFAFCTNLTELHLMSNSIQKIKNnpFVKQKNLITLDLSHNGLSStkLGTQVQLENLQELLLSNNKIQALKSEELDI 167
Cdd:COG4886 220 LPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTD--LPPLANLTNLKTLDLSNNQLTDLKLKELEL 294

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      168 FANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKW 247
Cdd:COG4886 295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374

                       250       260
                ....*....|....*....|...
1ZIW_A      248 TNLTMLDLSYNNLNVVGNDSFAW 270
Cdd:COG4886 375 LEATLLTLALLLLTLLLLLLTTT 397
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
25-389 3.67e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 3.67e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       25 TNITVLNLTHNQLRRLPAAnFTRYSQLTSLDVGFNTISKLEPELcQKLPMLKVLNLQHNELSQLSDkTFAFCTNLTELHL 104
Cdd:COG4886 113 TNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDL 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      105 MSNSIQKIKNnPFVKQKNLITLDLSHNGLSStklgtqvqlenlqelllsnnkiqalksEELDIFANSSLKKLELSSNQIK 184
Cdd:COG4886 190 SNNQITDLPE-PLGNLTNLEELDLSGNQLTD---------------------------LPEPLANLTNLETLDLSNNQLT 241

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      185 EFspgcfhaigrlfglflnnvqlgPSLTEklclelaNTSIRNLSLSNSQLSTTSNTtflgLKWTNLTMLDLSYNNLNVVG 264
Cdd:COG4886 242 DL----------------------PELGN-------LTNLEELDLSNNQLTDLPPL----ANLTNLKTLDLSNNQLTDLK 288

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      265 NDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGI 344
Cdd:COG4886 289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLT 368

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
1ZIW_A      345 KSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLT 389
Cdd:COG4886 369 LGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 46-516 5.29e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 66.02  E-value: 5.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A        46 TRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELS-QLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKqkNLI 124
Cdd:PLN00113  66 NNSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIP--NLE 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       125 TLDLSHNGLSStklgtqvqlenlqelllsnnKIQAlkseelDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNN 204
Cdd:PLN00113 144 TLDLSNNMLSG--------------------EIPN------DIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLAS 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       205 VQLgpslTEKLCLELANT-SIRNLSLSNSQLSTTSNTTFLGLkwTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNN 283
Cdd:PLN00113 198 NQL----VGQIPRELGQMkSLKWIYLGYNNLSGEIPYEIGGL--TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNK 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       284 IQHLFSHSLHGLFNVRYLNLKRSFTKQSIslaslPKIddfsFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSL-SN 362
Cdd:PLN00113 272 LSGPIPPSIFSLQKLISLDLSDNSLSGEI-----PEL----VIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLwSN 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       363 SFTSlrtltnETFVSLA-HSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQE--------------------L 421
Cdd:PLN00113 343 KFSG------EIPKNLGkHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEipkslgacrslrrvrlqdnsF 416

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       422 TG---QEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVA-------------LKNVDSS--------PSPFQ 477
Cdd:PLN00113 417 SGelpSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKffgglpdsfgskrLENLDLSrnqfsgavPRKLG 496

                        490       500       510
                 ....*....|....*....|....*....|....*....
1ZIW_A       478 PLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNL 516
Cdd:PLN00113 497 SLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
10-261 1.06e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.18  E-value: 1.06e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       10 DCSHLKLTQVPDDLP--TNITVLNLTHNQLRRLPAAnFTRYSQLTSLDVGFNTISKLEPELcQKLPMLKVLNLQHNELSQ 87
Cdd:COG4886 165 DLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTD 242

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       88 LSDktFAFCTNLTELHLMSNSIQKIKnnPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDI 167
Cdd:COG4886 243 LPE--LGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      168 FANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKW 247
Cdd:COG4886 319 LLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398

                       250
                ....*....|....
1ZIW_A      248 TNLTMLDLSYNNLN 261
Cdd:COG4886 399 GVLLLTLALLDAVN 412
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 328-514 2.61e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 2.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      328 LKCLEHLNMEDNDIPGIKSnmFTGLINLKYLSL-SNSFTSLRTLtnETFVSLAHsplhiLNLTKNKISKIESdaFSWLGH 406
Cdd:cd21340   1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLyDNKITKIENL--EFLTNLTH-----LYLQNNQIEKIEN--LENLVN 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      407 LEVLDLGLNEIgQELTGQEwrGLENIFEIYLSY------NKYLQLTRNSFALVPSLQRLMLRRVALknvdSSPSPFQPLR 480
Cdd:cd21340  70 LKKLYLGGNRI-SVVEGLE--NLTNLEELHIENqrlppgEKLTFDPRSLAALSNSLRVLNISGNNI----DSLEPLAPLR 142

                       170       180       190
                ....*....|....*....|....*....|....*.
1ZIW_A      481 NLTILDLS--NNNIANINDDMLEGLEKLEILDLQHN 514
Cdd:cd21340 143 NLEQLDASnnQISDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
248-303 3.21e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.21e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
1ZIW_A        248 TNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNL 303
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDL 56
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-446 4.99e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.71  E-value: 4.99e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       72 LPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELL 151
Cdd:COG4886   8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      152 LSNNKIQALKSEELDIFAN------SSLKKLELSSNQIKEFSPgcfhAIGRLfglflnnvqlgpslteklclelanTSIR 225
Cdd:COG4886  88 GLTDLGDLTNLTELDLSGNeelsnlTNLESLDLSGNQLTDLPE----ELANL------------------------TNLK 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      226 NLSLSNSQLstTSNTTFLGlKWTNLTMLDLSYNNLNVVGnDSFAWLPQLEYFFLEYNNIQHLfSHSLHGLFNVRYLNLKR 305
Cdd:COG4886 140 ELDLSNNQL--TDLPEPLG-NLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSG 214

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      306 S-FTKQSISLASLPKiddfsfqwlkcLEHLNMEDNDIPGIKSnmFTGLINLKYLSLSN----SFTSLRTLTNETFVSLAH 380
Cdd:COG4886 215 NqLTDLPEPLANLTN-----------LETLDLSNNQLTDLPE--LGNLTNLEELDLSNnqltDLPPLANLTNLKTLDLSN 281

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
1ZIW_A      381 SPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLT 446
Cdd:COG4886 282 NQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLL 347
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
258-640 8.21e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 8.21e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      258 NNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNME 337
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      338 DNDIPGIKSNMFTGLINLKYLSLSNSfTSLRTLTNetfvslahspLHILNLTKNKISKIEsDAFSWLGHLEVLDLGLNEI 417
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGN-EELSNLTN----------LESLDLSGNQLTDLP-EELANLTNLKELDLSNNQL 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      418 GQelTGQEWRGLENIFEIYLSYNKYLQLTrNSFALVPSLQRLMLRRVALKNVdssPSPFQPLRNLTILDLSNNNIANIND 497
Cdd:COG4886 149 TD--LPEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPE 222

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      498 DmLEGLEKLEILDLQHNNLARLwkhanpggpiYFLKGLSHLHILNLESNGFDEIPVEvfKDLFELKIIDLGLNNLNTLPA 577
Cdd:COG4886 223 P-LANLTNLETLDLSNNQLTDL----------PELGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKL 289

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|...
1ZIW_A      578 SVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHT 640
Cdd:COG4886 290 KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTL 352
LRR_8 pfam13855
Leucine rich repeat;
222-284 8.38e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 8.38e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
1ZIW_A        222 TSIRNLSLSNSQLSTTSNTTFLGLKwtNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNI 284
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLS--NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
49-109 2.46e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.46e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
1ZIW_A         49 SQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSI 109
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
14-183 3.70e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 3.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A        14 LKLTQVPDDLPTNITVLNLTHNQLRRLPA---AN----FTRYSQLTSLDVGF-NTISKLE------PELCQKLP-MLKVL 78
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPEnlqGNiktlYANSNQLTSIPATLpDTIQEMElsinriTELPERLPsALQSL 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A        79 NLQHNELSQLSD------KTFAFCTN------------LTELHLMSNSIQKIknnPFVKQKNLITLDLSHNGLSSTKlgt 140
Cdd:PRK15370 268 DLFHNKISCLPEnlpeelRYLSVYDNsirtlpahlpsgITHLNVQSNSLTAL---PETLPPGLKTLEAGENALTSLP--- 341

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
1ZIW_A       141 QVQLENLQELLLSNNKIQALKS------EELDIFAN----------SSLKKLELSSNQI 183
Cdd:PRK15370 342 ASLPPELQVLDVSKNQITVLPEtlpptiTTLDVSRNaltnlpenlpAALQIMQASRNNL 400
LRRCT smart00082
Leucine rich repeat C-terminal domain;
619-671 3.71e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.04  E-value: 3.71e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
1ZIW_A         619 NPFDCTCEsIAWFVNWINET-HTNIPElssHYLCNTPPHYHGfPVRLFDTSS--CK 671
Cdd:smart00082   1 NPFICDCE-LRWLLRWLQANeHLQDPV---DLRCASPSSLRG-PLLELLHSEfkCP 51
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 11-181 4.55e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.33  E-value: 4.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       11 CSHLKLTQVPD-DLPTNITVLNLTHNQLRRLPaaNFTRYSQLTSLDVGFNTISKLEPElcQKLPMLKVLNLQHNELSQLS 89
Cdd:cd21340   9 LNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENL--ENLVNLKKLYLGGNRISVVE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       90 DktFAFCTNLTELHLMSNSIQKikNNPFVK--------QKNLITLDLSHNGLSStkLGTQVQLENLQELLLSNNKIQALK 161
Cdd:cd21340  85 G--LENLTNLEELHIENQRLPP--GEKLTFdprslaalSNSLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLE 158

                       170       180
                ....*....|....*....|
1ZIW_A      162 SEELDIFANSSLKKLELSSN 181
Cdd:cd21340 159 ELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
25-85 7.99e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 7.99e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
1ZIW_A         25 TNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNEL 85
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 590-662 1.10e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.39  E-value: 1.10e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
1ZIW_A         590 NLQKNLITSVEKKVFGPAFrNLTELDMRFNPFDCTCeSIAWFVNWINETHTNI--PELSshyLCNTPPHYHGFPV 662
Cdd:TIGR00864    1 DISNNKISTIEEGICANLC-NLSEIDLSGNPFECDC-GLARLPRWAEEKGVKVrqPEAA---LCAGPGALAGQPL 70
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
197-596 1.33e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.09  E-value: 1.33e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      197 LFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEY 276
Cdd:COG4886  21 LTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTE 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      277 FFLEYNNiqhlfshSLHGLFNVRYLNLKRSftkqsiSLASLPKiddfSFQWLKCLEHLNMEDNDIPGIKSNmFTGLINLK 356
Cdd:COG4886 101 LDLSGNE-------ELSNLTNLESLDLSGN------QLTDLPE----ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      357 YLSLSNsfTSLRTLTNEtFVSLAHspLHILNLTKNKISKIeSDAFSWLGHLEVLDLGLNEIGQEltGQEWRGLENIFEIY 436
Cdd:COG4886 163 SLDLSN--NQLTDLPEE-LGNLTN--LKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL--PEPLANLTNLETLD 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      437 LSYNKYLQLTrnSFALVPSLQRLMLRRvalkNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNL 516
Cdd:COG4886 235 LSNNQLTDLP--ELGNLTNLEELDLSN----NQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      517 ARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLI 596
Cdd:COG4886 309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLT 388
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-375 1.70e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.09  E-value: 1.70e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       51 LTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNElsqlsdkTFAFCTNLTELHLMSNSIQKIKNNpFVKQKNLITLDLSH 130
Cdd:COG4886  74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSN 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      131 NGLSStkLGTQVQLENLQEL-LLSNNKIQALKSEeldIFANSSLKKLELSSNQIKEFsPGCFHAIGRLFGLFLNNVQLgp 209
Cdd:COG4886 146 NQLTD--LPEPLGNLTNLKSlDLSNNQLTDLPEE---LGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQL-- 217

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      210 sltEKLCLELAN-TSIRNLSLSNSQLSTTSNTTFLglkwTNLTMLDLSYNNLNVVgnDSFAWLPQLEYFFLEYNNIQHLF 288
Cdd:COG4886 218 ---TDLPEPLANlTNLETLDLSNNQLTDLPELGNL----TNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLK 288

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      289 SHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLR 368
Cdd:COG4886 289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLT 368


                ....*..
1ZIW_A      369 TLTNETF 375
Cdd:COG4886 369 LGLLGLL 375
LRR_8 pfam13855
Leucine rich repeat;
536-596 2.52e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 2.52e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
1ZIW_A        536 SHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLI 596
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
383-441 2.70e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 2.70e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
1ZIW_A        383 LHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIgQELTGQEWRGLENIFEIYLSYNK 441
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGAFSGLPSLRYLDLSGNR 60
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 505-621 6.15e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.89  E-value: 6.15e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      505 KLEILDLQHNNL----ARLWKHAnpggpiyfLKGLSHLHILNLESNGFDEIPV----EVFKDLFELKIIDLGLNNLNTLP 576
Cdd:cd00116 166 DLKELNLANNGIgdagIRALAEG--------LKANCNLEVLDLNNNGLTDEGAsalaETLASLKSLEVLNLGDNNLTDAG 237

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
1ZIW_A      577 ASVFNNQV-----SLKSLNLQKNLITSVEKKVFG---PAFRNLTELDMRFNPF 621
Cdd:cd00116 238 AAALASALlspniSLLTLSLSCNDITDDGAKDLAevlAEKESLLELDLRGNKF 290
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
10-135 9.35e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 9.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A        10 DCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAAnftRYSQLTSLDVGFNTISKLePElcqKLPM-LKVLNLQHNELSQL 88
Cdd:PRK15370 268 DLFHNKISCLPENLPEELRYLSVYDNSIRTLPAH---LPSGITHLNVQSNSLTAL-PE---TLPPgLKTLEAGENALTSL 340

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
1ZIW_A        89 SDKTfafctnLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSS 135
Cdd:PRK15370 341 PASL------PPELQVLDVSKNQITVLPETLPPTITTLDVSRNALTN 381
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-284 1.78e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.31  E-value: 1.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A        29 VLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPE-LCQKLPMLKVLnLQHNELSQLSDKTFAFCTNLTELHLMSN 107
Cdd:PLN00113 336 VLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEgLCSSGNLFKLI-LFSNSLEGEIPKSLGACRSLRRVRLQDN 414

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       108 SIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIqalkSEEL-DIFANSSLKKLELSSNQIKEF 186
Cdd:PLN00113 415 SFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKF----FGGLpDSFGSKRLENLDLSRNQFSGA 490

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       187 SPGCFHAIGRLFGLFLNNVQLGPSLTEKLclelanTSIRNLslsnsqlsttsnttflglkwtnlTMLDLSYNNLNVVGND 266
Cdd:PLN00113 491 VPRKLGSLSELMQLKLSENKLSGEIPDEL------SSCKKL-----------------------VSLDLSHNQLSGQIPA 541

                        250
                 ....*....|....*...
1ZIW_A       267 SFAWLPQLEYFFLEYNNI 284
Cdd:PLN00113 542 SFSEMPVLSQLDLSQNQL 559
LRR_8 pfam13855
Leucine rich repeat;
75-133 1.81e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 1.81e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
1ZIW_A         75 LKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGL 133
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
431-654 2.22e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.77  E-value: 2.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       431 NIFEIYLSYNkylQLTRNSFALVPSLQRLMLRRVALKNV-DSSPSPFQPLrnltilDLSNNNIANINDDMLEGLEKLEIL 509
Cdd:PRK15370 221 NIKTLYANSN---QLTSIPATLPDTIQEMELSINRITELpERLPSALQSL------DLFHNKISCLPENLPEELRYLSVY 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       510 DlqhNNLARLwkhanpggPIYFLKGLSHlhiLNLESNGFDEIPVEVFKDlfeLKIIDLGLNNLNTLPASVfnnQVSLKSL 589
Cdd:PRK15370 292 D---NSIRTL--------PAHLPSGITH---LNVQSNSLTALPETLPPG---LKTLEAGENALTSLPASL---PPELQVL 351

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
1ZIW_A       590 NLQKNLITsVEKKVFGPafrNLTELDMRFNPFDCTCESIAWFVNWINETHTN---IPELSSHYLCNTP 654
Cdd:PRK15370 352 DVSKNQIT-VLPETLPP---TITTLDVSRNALTNLPENLPAALQIMQASRNNlvrLPESLPHFRGEGP 415
LRR_8 pfam13855
Leucine rich repeat;
561-621 3.26e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 3.26e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
1ZIW_A        561 ELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPaFRNLTELDMRFNPF 621
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG-LPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 24-135 3.36e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.63  E-value: 3.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       24 PTNITVLNLTHNQLR----RLPAANFTRYSQLTSLDVGFNTIS-----KLEPELcQKLPMLKVLNLQHNELS----QLSD 90
Cdd:COG5238 263 NTTVETLYLSGNQIGaegaIALAKALQGNTTLTSLDLSVNRIGdegaiALAEGL-QGNKTLHTLNLAYNGIGaqgaIALA 341

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
1ZIW_A       91 KTFAFCTNLTELHLMSNSI---------QKIKNNPfvkqkNLITLDLSHNGLSS 135
Cdd:COG5238 342 KALQENTTLHSLDLSDNQIgdegaialaKYLEGNT-----TLRELNLGKNNIGK 390
LRR_8 pfam13855
Leucine rich repeat;
454-516 4.97e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 4.97e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
1ZIW_A        454 PSLQRLMLRRVALKNVDssPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNL 516
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD--DGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 18-86 5.12e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.27  E-value: 5.12e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
1ZIW_A        18 QVPDDLPT--NITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELS 86
Cdd:PLN03150 433 FIPNDISKlrHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 22-134 1.27e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A        22 DLPTnITVLNLTHNQ-LRRLPaaNFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLT 100
Cdd:PLN00113 450 DMPS-LQMLSLARNKfFGGLP--DSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLV 526

                         90       100       110
                 ....*....|....*....|....*....|....
1ZIW_A       101 ELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLS 134
Cdd:PLN00113 527 SLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLS 560
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 2-24 3.02e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 35.68  E-value: 3.02e-03
                          10        20
                  ....*....|....*....|...
1ZIW_A          2 CTVSHEVADCSHLKLTQVPDDLP 24
Cdd:pfam01462   6 CHCSATVVNCSDRGLTAVPRDLP 28
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 190-524 3.46e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 3.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       190 CFHAIGRLFGLFLNnvqLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNT--TFLGLKWTN---LTMLDLSYNNLNVVG 264
Cdd:PLN00113   9 CPYLIFMLFFLFLN---FSMLHAEELELLLSFKSSINDPLKYLSNWNSSADvcLWQGITCNNssrVVSIDLSGKNISGKI 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       265 NDSFAWLPQLEYFFLEYNNIQHLFSHSLHGL-FNVRYLNLKRSFTKQSISLASLPkiddfsfqwlkCLEHLNMEDNdipg 343
Cdd:PLN00113  86 SSAIFRLPYIQTINLSNNQLSGPIPDDIFTTsSSLRYLNLSNNNFTGSIPRGSIP-----------NLETLDLSNN---- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       344 iksnMFTGLINLKYlslsNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAF-----SWLGHLEVLD---LGLN 415
Cdd:PLN00113 151 ----MLSGEIPNDI----GSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvgqipRELGQMKSLKwiyLGYN 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       416 EIGQELTgQEWRGLENIFEIYLSYN----------------KYLQLTRNSFA-----LVPSLQRLmlrrVALKNVDSSPS 474
Cdd:PLN00113 223 NLSGEIP-YEIGGLTSLNHLDLVYNnltgpipsslgnlknlQYLFLYQNKLSgpippSIFSLQKL----ISLDLSDNSLS 297

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       475 PFQP-----LRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNL-----ARLWKHAN 524
Cdd:PLN00113 298 GEIPelviqLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFsgeipKNLGKHNN 357
LRR_8 pfam13855
Leucine rich repeat;
354-417 3.85e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 3.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
1ZIW_A        354 NLKYLSLSNSftSLRTLTNETFVSLAHspLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEI 417
Cdd:pfam13855   2 NLRSLDLSNN--RLTSLDDGAFKGLSN--LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
272-341 3.93e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 3.93e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A        272 PQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSftkqsislaSLPKIDDFSFQWLKCLEHLNMEDNDI 341
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN---------LLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
2-28 4.28e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 35.37  E-value: 4.28e-03
                           10        20
                   ....*....|....*....|....*..
1ZIW_A           2 CTVSHEVADCSHLKLTQVPDDLPTNIT 28
Cdd:smart00013   6 CNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRR_8 pfam13855
Leucine rich repeat;
97-135 6.88e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 6.88e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
1ZIW_A         97 TNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSS 135
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT 39
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 25-258 7.63e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 7.63e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A       25 TNITVLNLTHNQLRRLPaaNFTRYSQLTSLDVGFNTISKLEPelCQKLPMLKVLNLQHNELSQLSDktFAFCTNLTELHL 104
Cdd:cd21340   2 KRITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIW_A      105 MSNSIQKIKNnpFVKQKNLITLDLSHNGLSSTklgtqvqlenlqelllsnnkiQALKSEELDIFANS-SLKKLELSSNQI 183
Cdd:cd21340  76 GGNRISVVEG--LENLTNLEELHIENQRLPPG---------------------EKLTFDPRSLAALSnSLRVLNISGNNI 132

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
1ZIW_A      184 kefspgcfhaigrlfglflnnvqlgPSLTEKLCLelanTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYN 258
Cdd:cd21340 133 -------------------------DSLEPLAPL----RNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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