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Conserved domains on  [gi|291463371|pdb|2KUA|A]
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Chain A, Bcl-2-like protein 10

Protein Classification

bcl-2 family protein( domain architecture ID 10646640)

bcl-2 family protein similar to Homo sapiens apoptosis regulators, Bcl-2 and BAX

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BCL smart00337
BCL (B-Cell lymphoma); contains BH1, BH2 regions; (BH1, BH2, (BH3 (one helix only)) and not ...
 47-156 2.10e-21

BCL (B-Cell lymphoma); contains BH1, BH2 regions; (BH1, BH2, (BH3 (one helix only)) and not BH4(one helix only)). Involved in apoptosis regulation


:

Pssm-ID: 214626  Cd Length: 100  Bit Score: 83.14  E-value: 2.10e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2KUA_A          47 LRSVTRQIQQEHQEFFSSFCESR----GNRLELVKQMADKLLSkDQDFSWSQLVMLLAFAGTLMNQGPYmavKQKRDLGN 122
Cdd:smart00337   1 LRRVGDELNKRYERAFSSFSAQLhvtpGTAIELFGEVATELFS-DGNINWGRVVALLSFGGALAVKLVQ---KEDPDLVS 76

                           90       100       110
                   ....*....|....*....|....*....|....
2KUA_A         123 RVIVTrdcclIVNFLYNLLmgrrhRARLEALGGW 156
Cdd:smart00337  77 RLASW-----LSEFLRETL-----RSWIRENGGW 100
 
Name Accession Description Interval E-value
BCL smart00337
BCL (B-Cell lymphoma); contains BH1, BH2 regions; (BH1, BH2, (BH3 (one helix only)) and not ...
 47-156 2.10e-21

BCL (B-Cell lymphoma); contains BH1, BH2 regions; (BH1, BH2, (BH3 (one helix only)) and not BH4(one helix only)). Involved in apoptosis regulation


Pssm-ID: 214626  Cd Length: 100  Bit Score: 83.14  E-value: 2.10e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2KUA_A          47 LRSVTRQIQQEHQEFFSSFCESR----GNRLELVKQMADKLLSkDQDFSWSQLVMLLAFAGTLMNQGPYmavKQKRDLGN 122
Cdd:smart00337   1 LRRVGDELNKRYERAFSSFSAQLhvtpGTAIELFGEVATELFS-DGNINWGRVVALLSFGGALAVKLVQ---KEDPDLVS 76

                           90       100       110
                   ....*....|....*....|....*....|....
2KUA_A         123 RVIVTrdcclIVNFLYNLLmgrrhRARLEALGGW 156
Cdd:smart00337  77 RLASW-----LSEFLRETL-----RSWIRENGGW 100
Bcl-2_like cd06845
Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This ...
 14-162 7.12e-19

Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane segment. Some homologous proteins, which are not included in this model, may miss either the BH4 (Bax, Bak) or the BH2 (Bcl-X(S)) region, and some appear to only share the BH3 region (Bik, Bim, Bad, Bid, Egl-1). This family is involved in the regulation of the outer mitochondrial membrane's permeability and in promoting or preventing the release of apoptogenic factors, which in turn may trigger apoptosis by activating caspases. Bcl-2 and the closely related Bcl-X(L) are anti-apoptotic key regulators of programmed cell death. They are assumed to function via heterodimeric protein-protein interactions, binding pro-apoptotic proteins such as Bad (BCL2-antagonist of cell death), Bid, and Bim, by specifically interacting with their BH3 regions. Interfering with this heterodimeric interaction via small-molecule inhibitors may prove effective in targeting various cancers. This family also includes the Caenorhabditis elegans Bcl-2 homolog CED-9, which binds to CED-4, the C. Elegans homolog of mammalian Apaf-1. Apaf-1, however, does not seem to be inhibited by Bcl-2 directly.


Pssm-ID: 132900 [Multi-domain]  Cd Length: 144  Bit Score: 78.14  E-value: 7.12e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2KUA_A       14 HERTRRLLSDYIFFCAREPDTPEPPPT-----SVEAALLRSVTRQIQQEHQEFFSSFCE----SRGNRLELVKQMADKLL 84
Cdd:cd06845   1 DEITRRLARDYLRYRLGEPETPNSPLPsgsppSEVAETLRRVGDELEEKHRRLFENMCRqlniSPDNAYEVFQEVARELF 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
2KUA_A       85 SkDQDFSWSQLVMLLAFAGTLmnqgpymAVKQKRdLGNRVIVTRDCCLIVNFLynllmgRRHRAR-LEALGGWDGFCRF 162
Cdd:cd06845  81 E-DGGINWGRIVALFAFGGRL-------AVKCVE-QGLPELVRSIAEWTSDFL------EENLADwIQENGGWDGFVEF 144
Bcl-2 pfam00452
Apoptosis regulator proteins, Bcl-2 family;
47-156 1.41e-10

Apoptosis regulator proteins, Bcl-2 family;


Pssm-ID: 459816  Cd Length: 101  Bit Score: 55.34  E-value: 1.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2KUA_A         47 LRSVTRQIQQEHQEFFSSFCE-----SRGNRLELVKQMADKLLSkDQDFSWSQLVMLLAFAGTLmnqgpymAVKQKRDLg 121
Cdd:pfam00452   1 LRRLGDELERKHPELFQNMLNqllltPEDTAYELFREVADELFS-DGVINWGRVVALFAFAGAL-------AVKLVRQG- 71

                          90       100       110
                  ....*....|....*....|....*....|....*
2KUA_A        122 nrviVTRDCCLIVNFLYNLLMGrRHRARLEALGGW 156
Cdd:pfam00452  72 ----HPELVRRLAEWLVDYLEE-RLADWIIQQGGW 101
 
Name Accession Description Interval E-value
BCL smart00337
BCL (B-Cell lymphoma); contains BH1, BH2 regions; (BH1, BH2, (BH3 (one helix only)) and not ...
 47-156 2.10e-21

BCL (B-Cell lymphoma); contains BH1, BH2 regions; (BH1, BH2, (BH3 (one helix only)) and not BH4(one helix only)). Involved in apoptosis regulation


Pssm-ID: 214626  Cd Length: 100  Bit Score: 83.14  E-value: 2.10e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2KUA_A          47 LRSVTRQIQQEHQEFFSSFCESR----GNRLELVKQMADKLLSkDQDFSWSQLVMLLAFAGTLMNQGPYmavKQKRDLGN 122
Cdd:smart00337   1 LRRVGDELNKRYERAFSSFSAQLhvtpGTAIELFGEVATELFS-DGNINWGRVVALLSFGGALAVKLVQ---KEDPDLVS 76

                           90       100       110
                   ....*....|....*....|....*....|....
2KUA_A         123 RVIVTrdcclIVNFLYNLLmgrrhRARLEALGGW 156
Cdd:smart00337  77 RLASW-----LSEFLRETL-----RSWIRENGGW 100
Bcl-2_like cd06845
Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This ...
 14-162 7.12e-19

Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane segment. Some homologous proteins, which are not included in this model, may miss either the BH4 (Bax, Bak) or the BH2 (Bcl-X(S)) region, and some appear to only share the BH3 region (Bik, Bim, Bad, Bid, Egl-1). This family is involved in the regulation of the outer mitochondrial membrane's permeability and in promoting or preventing the release of apoptogenic factors, which in turn may trigger apoptosis by activating caspases. Bcl-2 and the closely related Bcl-X(L) are anti-apoptotic key regulators of programmed cell death. They are assumed to function via heterodimeric protein-protein interactions, binding pro-apoptotic proteins such as Bad (BCL2-antagonist of cell death), Bid, and Bim, by specifically interacting with their BH3 regions. Interfering with this heterodimeric interaction via small-molecule inhibitors may prove effective in targeting various cancers. This family also includes the Caenorhabditis elegans Bcl-2 homolog CED-9, which binds to CED-4, the C. Elegans homolog of mammalian Apaf-1. Apaf-1, however, does not seem to be inhibited by Bcl-2 directly.


Pssm-ID: 132900 [Multi-domain]  Cd Length: 144  Bit Score: 78.14  E-value: 7.12e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2KUA_A       14 HERTRRLLSDYIFFCAREPDTPEPPPT-----SVEAALLRSVTRQIQQEHQEFFSSFCE----SRGNRLELVKQMADKLL 84
Cdd:cd06845   1 DEITRRLARDYLRYRLGEPETPNSPLPsgsppSEVAETLRRVGDELEEKHRRLFENMCRqlniSPDNAYEVFQEVARELF 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
2KUA_A       85 SkDQDFSWSQLVMLLAFAGTLmnqgpymAVKQKRdLGNRVIVTRDCCLIVNFLynllmgRRHRAR-LEALGGWDGFCRF 162
Cdd:cd06845  81 E-DGGINWGRIVALFAFGGRL-------AVKCVE-QGLPELVRSIAEWTSDFL------EENLADwIQENGGWDGFVEF 144
Bcl-2 pfam00452
Apoptosis regulator proteins, Bcl-2 family;
47-156 1.41e-10

Apoptosis regulator proteins, Bcl-2 family;


Pssm-ID: 459816  Cd Length: 101  Bit Score: 55.34  E-value: 1.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2KUA_A         47 LRSVTRQIQQEHQEFFSSFCE-----SRGNRLELVKQMADKLLSkDQDFSWSQLVMLLAFAGTLmnqgpymAVKQKRDLg 121
Cdd:pfam00452   1 LRRLGDELERKHPELFQNMLNqllltPEDTAYELFREVADELFS-DGVINWGRVVALFAFAGAL-------AVKLVRQG- 71

                          90       100       110
                  ....*....|....*....|....*....|....*
2KUA_A        122 nrviVTRDCCLIVNFLYNLLMGrRHRARLEALGGW 156
Cdd:pfam00452  72 ----HPELVRRLAEWLVDYLEE-RLADWIIQQGGW 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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