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Conserved domains on  [gi|238537747|pdb|3D1N|N]
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Chain N, POU domain, class 6, transcription factor 1

Protein Classification

POU family transcription factor( domain architecture ID 11036637)

POU (Pit-Oct-Unc) family transcription factor binds specific DNA sequences to direct gene expression programs, playing a role in orchestrating embryonic development and directing cellular fate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pou super family cl22952
Pou domain - N-terminal to homeobox domain;
1-72 1.29e-35

Pou domain - N-terminal to homeobox domain;


The actual alignment was detected with superfamily member smart00352:

Pssm-ID: 473999  Cd Length: 75  Bit Score: 117.92  E-value: 1.29e-35
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
3D1N_N           1 IN*EEIREFAKNFKIRRLSLGLTQTQVGQA*TATEGPAYSQSAISRFEKLDITPKSAQKLKPVLEKWLNEAE 72
Cdd:smart00352   4 TDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Homeodomain pfam00046
Homeodomain;
94-150 8.28e-17

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 69.45  E-value: 8.28e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
3D1N_N         94 RKRRTSFTPQAIEALNAYFEKNPLPTGQEITE*AKELNYDREVVRVWFSNRRQTLKN 150
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
1-72 1.29e-35

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 117.92  E-value: 1.29e-35
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
3D1N_N           1 IN*EEIREFAKNFKIRRLSLGLTQTQVGQA*TATEGPAYSQSAISRFEKLDITPKSAQKLKPVLEKWLNEAE 72
Cdd:smart00352   4 TDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
1-72 1.22e-33

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 112.75  E-value: 1.22e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
3D1N_N          1 IN*EEIREFAKNFKIRRLSLGLTQTQVGQA*TATEGPAYSQSAISRFEKLDITPKSAQKLKPVLEKWLNEAE 72
Cdd:pfam00157   1 LNLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
94-150 8.28e-17

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 69.45  E-value: 8.28e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
3D1N_N         94 RKRRTSFTPQAIEALNAYFEKNPLPTGQEITE*AKELNYDREVVRVWFSNRRQTLKN 150
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 93-149 4.61e-15

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 64.96  E-value: 4.61e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
3D1N_N          93 KRKRRTSFTPQAIEALNAYFEKNPLPTGQEITE*AKELNYDREVVRVWFSNRRQTLK 149
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 94-151 2.61e-13

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 60.72  E-value: 2.61e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
3D1N_N       94 RKRRTSFTPQAIEALNAYFEKNPLPTGQEITE*AKELNYDREVVRVWFSNRRQTLKNT 151
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
41-149 2.60e-06

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 44.35  E-value: 2.60e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3D1N_N       41 QSAISRFEKLDItpKSAQKLKPvlEKWLNEAElrNQEGQQNL*EFVGGEPSKKRKRRTSfTPQAIEALNAYFEKNPLPTG 120
Cdd:COG5576   6 MQPLSALESQRM--PQIRTIKT--TKNKREVE--AADSEMKLERKQDGSSPPKSKRRRT-TDEQLMVLEREFEINPYPSS 78

                        90       100
                ....*....|....*....|....*....
3D1N_N      121 QEITE*AKELNYDREVVRVWFSNRRQTLK 149
Cdd:COG5576  79 ITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
1-72 1.29e-35

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 117.92  E-value: 1.29e-35
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
3D1N_N           1 IN*EEIREFAKNFKIRRLSLGLTQTQVGQA*TATEGPAYSQSAISRFEKLDITPKSAQKLKPVLEKWLNEAE 72
Cdd:smart00352   4 TDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
1-72 1.22e-33

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 112.75  E-value: 1.22e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
3D1N_N          1 IN*EEIREFAKNFKIRRLSLGLTQTQVGQA*TATEGPAYSQSAISRFEKLDITPKSAQKLKPVLEKWLNEAE 72
Cdd:pfam00157   1 LNLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
94-150 8.28e-17

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 69.45  E-value: 8.28e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
3D1N_N         94 RKRRTSFTPQAIEALNAYFEKNPLPTGQEITE*AKELNYDREVVRVWFSNRRQTLKN 150
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 93-149 4.61e-15

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 64.96  E-value: 4.61e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
3D1N_N          93 KRKRRTSFTPQAIEALNAYFEKNPLPTGQEITE*AKELNYDREVVRVWFSNRRQTLK 149
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 94-151 2.61e-13

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 60.72  E-value: 2.61e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
3D1N_N       94 RKRRTSFTPQAIEALNAYFEKNPLPTGQEITE*AKELNYDREVVRVWFSNRRQTLKNT 151
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
41-149 2.60e-06

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 44.35  E-value: 2.60e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3D1N_N       41 QSAISRFEKLDItpKSAQKLKPvlEKWLNEAElrNQEGQQNL*EFVGGEPSKKRKRRTSfTPQAIEALNAYFEKNPLPTG 120
Cdd:COG5576   6 MQPLSALESQRM--PQIRTIKT--TKNKREVE--AADSEMKLERKQDGSSPPKSKRRRT-TDEQLMVLEREFEINPYPSS 78

                        90       100
                ....*....|....*....|....*....
3D1N_N      121 QEITE*AKELNYDREVVRVWFSNRRQTLK 149
Cdd:COG5576  79 ITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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