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Conserved domains on  [gi|315113405|pdb|3LE1|B]
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Chain B, Phosphotransferase system, HPr-related proteins

Protein Classification

HPr family phosphocarrier protein( domain architecture ID 10788234)

HPr family phosphocarrier protein is part of a phosphoenolpyruvate-dependent phosphotransferase (PTS)-like system that catalyzes the phosphorylation of incoming substrates with their concomitant translocation across the cell membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
 1-88 5.45e-49

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


:

Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 149.48  E-value: 5.45e-49
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LE1_B       1 MKEVTIEIKNKTGLHARPAALFVQTASKFSSQIWVEKDNKKVNAKSIMGIMSLGVSQGNVVKLSAEGDDEEEAIKALVDL 80
Cdd:COG1925  1 MLEREVTIVNKLGLHARPAAKLVQLASKFDSEITVEKGGKEVNAKSIMGLMSLGAKKGDEVTITAEGPDAEEALDALAAL 80


               ....*...
3LE1_B      81 IESKFGEE 88
Cdd:COG1925 81 IESGFGEE 88
 
Name Accession Description Interval E-value
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
 1-88 5.45e-49

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 149.48  E-value: 5.45e-49
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LE1_B       1 MKEVTIEIKNKTGLHARPAALFVQTASKFSSQIWVEKDNKKVNAKSIMGIMSLGVSQGNVVKLSAEGDDEEEAIKALVDL 80
Cdd:COG1925  1 MLEREVTIVNKLGLHARPAAKLVQLASKFDSEITVEKGGKEVNAKSIMGLMSLGAKKGDEVTITAEGPDAEEALDALAAL 80


               ....*...
3LE1_B      81 IESKFGEE 88
Cdd:COG1925 81 IESGFGEE 88
PTS-HPr pfam00381
PTS HPr component phosphorylation site;
5-82 1.10e-42

PTS HPr component phosphorylation site;


Pssm-ID: 459792 [Multi-domain]  Cd Length: 79  Bit Score: 133.28  E-value: 1.10e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
3LE1_B         5 TIEIKNKTGLHARPAALFVQTASKFSSQIWVEKDNKKVNAKSIMGIMSLGVSQGNVVKLSAEGDDEEEAIKALVDLIE 82
Cdd:pfam00381  2 TVTITNPLGLHARPAALLVQLASKFDSDITLEKGGKKVNAKSIMGLMSLGAKQGDEITISAEGEDEEEALEALAALLE 79
PTS-HPr_like cd00367
Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of ...
 5-81 2.80e-37

Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate is transferred to HPr by enzyme I (EI). Phospho-HPr then transfers the phosphoryl group to one of several sugar-specific phosphoprotein intermediates. The conserved histidine in the N-terminus of HPr serves as an acceptor for the phosphoryl group of EI. In addition to the phosphotransferase proteins HPr and E1, this family also includes the closely related Carbon Catabolite Repressor (CCR) proteins which use the same phosphorylation mechanism and interact with transcriptional regulators to control expression of genes coding for utilization of less favored carbon sources.


Pssm-ID: 238217 [Multi-domain]  Cd Length: 77  Bit Score: 119.54  E-value: 2.80e-37
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
3LE1_B       5 TIEIKNKTGLHARPAALFVQTASKFSSQIWVEKDNKKVNAKSIMGIMSLGVSQGNVVKLSAEGDDEEEAIKALVDLI 81
Cdd:cd00367  1 TVTITNPLGLHARPAALLVQLASKFKSDITLRKGGRKANAKSILGLMSLGAKQGDEITLSAEGEDAEEALEALAELL 77
PTS_HPr_family TIGR01003
Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains ...
 1-82 4.25e-36

Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains of proteins) which function in phosphoryl transfer system (PTS) systems. They include energy-coupling components which catalyze sugar uptake via a group translocation mechanism. The functions of most of these proteins are not known, but they presumably function in PTS-related regulatory capacities. All seed members are stand-alone HPr proteins, although the model also recognizes HPr domains of PTS fusion proteins. This family includes the related NPr protein. [Signal transduction, PTS]


Pssm-ID: 273389 [Multi-domain]  Cd Length: 82  Bit Score: 116.98  E-value: 4.25e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LE1_B         1 MKEVTIEIKNKTGLHARPAALFVQTASKFSSQIWVEKDNKKVNAKSIMGIMSLGVSQGNVVKLSAEGDDEEEAIKALVDL 80
Cdd:TIGR01003  1 MLSKEVTIINKVGLHARPAAILVKLASGFDSEITLTKNGKEVNAKSIMGIMMLGAGQGTEVTVSADGEDEAEALEALAKL 80


                 ..
3LE1_B        81 IE 82
Cdd:TIGR01003 81 FE 82
PRK13782 PRK13782
HPr family phosphocarrier protein;
1-82 3.68e-34

HPr family phosphocarrier protein;


Pssm-ID: 172320 [Multi-domain]  Cd Length: 82  Bit Score: 112.18  E-value: 3.68e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LE1_B        1 MKEVTIEIKNKTGLHARPAALFVQTASKFSSQIWVEKDNKKVNAKSIMGIMSLGVSQGNVVKLSAEGDDEEEAIKALVDL 80
Cdd:PRK13782  1 MVQKRVEVSLKTGLQARPAALFVQEANRFHADIFIEKDGKKVNAKSIMGLMSLAIGTGSMITIITEGSDEEEALEALAAY 80


                ..
3LE1_B       81 IE 82
Cdd:PRK13782 81 VQ 82
PTS-HPr_Halo NF041319
phosphocarrier protein HPr;
3-83 5.84e-22

phosphocarrier protein HPr;


Pssm-ID: 469216 [Multi-domain]  Cd Length: 87  Bit Score: 81.19  E-value: 5.84e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LE1_B        3 EVTIEIKNKTGLHARPAALFVQTASKFSSQIWV---EKDNKKVNAKSIMGIMSLGVSQGNVVKLSAEGDDEEEAIKALVD 79
Cdd:NF041319  2 ERTVTVVPEAGLHARPASKFVETANEFDAEVTVgraDDDGDLVNAASMLAVTGLGVRHGEDVRLVAEGDDAEAALDALEA 81


                ....
3LE1_B       80 LIES 83
Cdd:NF041319 82 VLST 85
 
Name Accession Description Interval E-value
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
 1-88 5.45e-49

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 149.48  E-value: 5.45e-49
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LE1_B       1 MKEVTIEIKNKTGLHARPAALFVQTASKFSSQIWVEKDNKKVNAKSIMGIMSLGVSQGNVVKLSAEGDDEEEAIKALVDL 80
Cdd:COG1925  1 MLEREVTIVNKLGLHARPAAKLVQLASKFDSEITVEKGGKEVNAKSIMGLMSLGAKKGDEVTITAEGPDAEEALDALAAL 80


               ....*...
3LE1_B      81 IESKFGEE 88
Cdd:COG1925 81 IESGFGEE 88
PTS-HPr pfam00381
PTS HPr component phosphorylation site;
5-82 1.10e-42

PTS HPr component phosphorylation site;


Pssm-ID: 459792 [Multi-domain]  Cd Length: 79  Bit Score: 133.28  E-value: 1.10e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
3LE1_B         5 TIEIKNKTGLHARPAALFVQTASKFSSQIWVEKDNKKVNAKSIMGIMSLGVSQGNVVKLSAEGDDEEEAIKALVDLIE 82
Cdd:pfam00381  2 TVTITNPLGLHARPAALLVQLASKFDSDITLEKGGKKVNAKSIMGLMSLGAKQGDEITISAEGEDEEEALEALAALLE 79
PTS-HPr_like cd00367
Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of ...
 5-81 2.80e-37

Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate is transferred to HPr by enzyme I (EI). Phospho-HPr then transfers the phosphoryl group to one of several sugar-specific phosphoprotein intermediates. The conserved histidine in the N-terminus of HPr serves as an acceptor for the phosphoryl group of EI. In addition to the phosphotransferase proteins HPr and E1, this family also includes the closely related Carbon Catabolite Repressor (CCR) proteins which use the same phosphorylation mechanism and interact with transcriptional regulators to control expression of genes coding for utilization of less favored carbon sources.


Pssm-ID: 238217 [Multi-domain]  Cd Length: 77  Bit Score: 119.54  E-value: 2.80e-37
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
3LE1_B       5 TIEIKNKTGLHARPAALFVQTASKFSSQIWVEKDNKKVNAKSIMGIMSLGVSQGNVVKLSAEGDDEEEAIKALVDLI 81
Cdd:cd00367  1 TVTITNPLGLHARPAALLVQLASKFKSDITLRKGGRKANAKSILGLMSLGAKQGDEITLSAEGEDAEEALEALAELL 77
PTS_HPr_family TIGR01003
Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains ...
 1-82 4.25e-36

Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains of proteins) which function in phosphoryl transfer system (PTS) systems. They include energy-coupling components which catalyze sugar uptake via a group translocation mechanism. The functions of most of these proteins are not known, but they presumably function in PTS-related regulatory capacities. All seed members are stand-alone HPr proteins, although the model also recognizes HPr domains of PTS fusion proteins. This family includes the related NPr protein. [Signal transduction, PTS]


Pssm-ID: 273389 [Multi-domain]  Cd Length: 82  Bit Score: 116.98  E-value: 4.25e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LE1_B         1 MKEVTIEIKNKTGLHARPAALFVQTASKFSSQIWVEKDNKKVNAKSIMGIMSLGVSQGNVVKLSAEGDDEEEAIKALVDL 80
Cdd:TIGR01003  1 MLSKEVTIINKVGLHARPAAILVKLASGFDSEITLTKNGKEVNAKSIMGIMMLGAGQGTEVTVSADGEDEAEALEALAKL 80


                 ..
3LE1_B        81 IE 82
Cdd:TIGR01003 81 FE 82
PRK13782 PRK13782
HPr family phosphocarrier protein;
1-82 3.68e-34

HPr family phosphocarrier protein;


Pssm-ID: 172320 [Multi-domain]  Cd Length: 82  Bit Score: 112.18  E-value: 3.68e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LE1_B        1 MKEVTIEIKNKTGLHARPAALFVQTASKFSSQIWVEKDNKKVNAKSIMGIMSLGVSQGNVVKLSAEGDDEEEAIKALVDL 80
Cdd:PRK13782  1 MVQKRVEVSLKTGLQARPAALFVQEANRFHADIFIEKDGKKVNAKSIMGLMSLAIGTGSMITIITEGSDEEEALEALAAY 80


                ..
3LE1_B       81 IE 82
Cdd:PRK13782 81 VQ 82
PRK13780 PRK13780
phosphocarrier protein HPr; Provisional
 1-83 1.63e-30

phosphocarrier protein HPr; Provisional


Pssm-ID: 237503 [Multi-domain]  Cd Length: 88  Bit Score: 102.85  E-value: 1.63e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LE1_B        1 MKEVTIEIKNKTGLHARPAALFVQTASKFSSQIWVEKDNKKVNAKSIMGIMSLGVSQGNVVKLSAEGDDEEEAIKALVDL 80
Cdd:PRK13780  1 MASKDFHITAETGIHARPATLLVQTASKFDSDITLEYNGKSVNLKSIMGVMSLGVGQGADITISAEGADAADAIAAIEET 80


                ...
3LE1_B       81 IES 83
Cdd:PRK13780 81 MKK 83
PRK11109 PRK11109
fused PTS fructose transporter subunit IIA/HPr protein;
8-87 3.39e-23

fused PTS fructose transporter subunit IIA/HPr protein;


Pssm-ID: 236849 [Multi-domain]  Cd Length: 375  Bit Score: 90.39  E-value: 3.39e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LE1_B         8 IKNKTGLHARPAALFVQTASKFSSQIWVEK---DNKKVNAKSIMGIMSLGVSQGNVVKLSAEGDDEEEAIKALVDLIESK 84
Cdd:PRK11109 292 IRNEHGLHARPGAMLVNTIKQFNSEITVTNldgTGKPANGRSLMKVVALGVKKGHRLRFTAQGEDAEQALKAIGEAIAAG 371


                 ...
3LE1_B        85 FGE 87
Cdd:PRK11109 372 LGE 374
PTS-HPr_Halo NF041319
phosphocarrier protein HPr;
3-83 5.84e-22

phosphocarrier protein HPr;


Pssm-ID: 469216 [Multi-domain]  Cd Length: 87  Bit Score: 81.19  E-value: 5.84e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LE1_B        3 EVTIEIKNKTGLHARPAALFVQTASKFSSQIWV---EKDNKKVNAKSIMGIMSLGVSQGNVVKLSAEGDDEEEAIKALVD 79
Cdd:NF041319  2 ERTVTVVPEAGLHARPASKFVETANEFDAEVTVgraDDDGDLVNAASMLAVTGLGVRHGEDVRLVAEGDDAEAALDALEA 81


                ....
3LE1_B       80 LIES 83
Cdd:NF041319 82 VLST 85
PRK10850 PRK10850
phosphocarrier protein Hpr;
2-82 1.30e-20

phosphocarrier protein Hpr;


Pssm-ID: 182777 [Multi-domain]  Cd Length: 85  Bit Score: 77.86  E-value: 1.30e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LE1_B        2 KEVTIEIKNktGLHARPAALFVQTASKFSSQIWVEKDNKKVNAKSIMGIMSLGVSQGNVVKLSAEGDDEEEAIKALVDLI 81
Cdd:PRK10850  4 QEVTITAPN--GLHTRPAAQFVKEAKGFTSEITVTSNGKSASAKSLFKLQTLGLTQGTVVTISAEGEDEQKAVEHLVKLM 81


                .
3LE1_B       82 E 82
Cdd:PRK10850 82 A 82
PRK11377 PRK11377
dihydroxyacetone kinase subunit M; Provisional
 2-87 8.77e-19

dihydroxyacetone kinase subunit M; Provisional


Pssm-ID: 183108 [Multi-domain]  Cd Length: 473  Bit Score: 78.64  E-value: 8.77e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LE1_B         2 KEVTIEIKNKTGLHARPAALFVQTASKFSSQIWVEKDNKKVNAKSIMGIMSLGVSQGNVVKLSAEGDDEEEAIKALVDLI 81
Cdd:PRK11377 156 RSLSVVIKNRNGLHVRPASRLVYTLSTFNADMLLEKNGKCVTPESLNQIALLQVRYNDTLRLIAKGPEAEEALIAFRQLA 235


                 ....*.
3LE1_B        82 ESKFGE 87
Cdd:PRK11377 236 EDNFGE 241
PRK13779 PRK13779
bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional
 5-87 1.22e-18

bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional


Pssm-ID: 237502 [Multi-domain]  Cd Length: 503  Bit Score: 78.38  E-value: 1.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LE1_B         5 TIEIKNKTGLHARPAALFVQTASKFSSQIWVE---KDNKKVNAKSIMGIMSLGVSQGNVVKLSAEGDDEEEAIKALVDLI 81
Cdd:PRK13779 294 TFTIRNEHGLHARPSANLVNEVKKFTAKITVEnltRGSAPVSAKSLMKIVALGVTQGHRLRFVAEGEDAQQAIEALAKAI 373


                 ....*.
3LE1_B        82 ESKFGE 87
Cdd:PRK13779 374 AEGLGE 379
PRK13779 PRK13779
bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional
 3-87 1.00e-14

bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional


Pssm-ID: 237502 [Multi-domain]  Cd Length: 503  Bit Score: 67.21  E-value: 1.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LE1_B         3 EVTIEIKNKTGLHARPAALFVQTASKFSSQIWVE---KDNKKVNAKSIMGIMSLGVSQGNVVKLSAEGDDEEEAIKALVD 79
Cdd:PRK13779 416 EGVFVIKNEHGLHARPSAVLVNEVKKYNASVAVQnldRNTQLVSAKSLMKIVALGVVKGHRLRFVATGEEAQQAIDGIGA 495


                 ....*...
3LE1_B        80 LIESKFGE 87
Cdd:PRK13779 496 AIAAGLGE 503
PRK10897 PRK10897
PTS phosphocarrier protein NPr;
5-88 8.30e-14

PTS phosphocarrier protein NPr;


Pssm-ID: 182819 [Multi-domain]  Cd Length: 90  Bit Score: 60.61  E-value: 8.30e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LE1_B        5 TIEIKNKTGLHARPAALFVQTASKFSSQIWVEKD-NKKVNAKSIMGIMSLGVSQGNVVKLSAEGDDEEEAIKALVDLIES 83
Cdd:PRK10897  6 TVEIKNKLGMHARPAMKLFELVQGFDAEVLLRNDeGTEAEANSVIALLMLDSAKGRQIEVEATGPQEEEALAAVIALFNS 85


                ....*
3LE1_B       84 KFGEE 88
Cdd:PRK10897 86 GFDED 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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