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Conserved domains on  [gi|295789461|pdb|3LJB|A]
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Chain A, Interferon-induced GTP-binding protein Mx1

Protein Classification

dynamin-like GTPase family protein( domain architecture ID 10470547)

dynamin-like GTPase family protein similar to Mycobacterium tuberculosis isoniazid-induced proteins IniA and IniC, and to Saccharomyces cerevisiae mitofusin FZO1, an essential transmembrane GTPase that mediates mitochondrial fusion

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Dynamin_M pfam01031
Dynamin central region; This is the stalk region which lies between the GTPase domain, see ...
1-181 2.02e-58

Dynamin central region; This is the stalk region which lies between the GTPase domain, see pfam00350, and the pleckstrin homology (PH) domain, see pfam00169. This region dimerizes in a cross-like fashion forming a dynamin dimer in which the two G-domains are oriented in opposite directions.


:

Pssm-ID: 460033  Cd Length: 287  Bit Score: 187.73  E-value: 2.02e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LJB_A          1 EDENEKMFFLIDKVNAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGREL 80
Cdd:pfam01031 106 SDPAEKGKFLLQLITKFNQDFKNLIDGESEISTNELSGGARIRYIFNEIFPKSLEKIDPLENLSDEEIRTAIRNSRGIRL 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LJB_A         81 PGFVNYRTFETIVKQQIKALEEPAVDMLhtvtDMVRLAFTDVSIK---NFEEFFNLHRTAKSKIEDIRAEQEREGEKLIR 157
Cdd:pfam01031 186 PLFVPEKAFELLVKQQIKRLEEPALKCV----ELVYEELERIIHKctpELKRFPNLRERIKEVVEDLLRERLEPTEKMIR 261
                         170       180
                  ....*....|....*....|....*
3LJB_A        158 LHFQMEQ-IVYCQDQVYRGALQKVR 181
Cdd:pfam01031 262 SLIEMELaYINTNHPDFIGGLNAVR 286
GED smart00302
Dynamin GTPase effector domain;
206-271 1.43e-20

Dynamin GTPase effector domain;


:

Pssm-ID: 128597  Cd Length: 92  Bit Score: 83.44  E-value: 1.43e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
3LJB_A         206 DSSMEEIFQHLMAYHQEASKRISSHIPLIIQFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERSDT 271
Cdd:smart00302   3 DSELEEIKSLVKSYFTIVSKTLADQVPKAIMYLLVNESKDSLQNELLALLYKEELLDELLEEDPEI 68
 
Name Accession Description Interval E-value
Dynamin_M pfam01031
Dynamin central region; This is the stalk region which lies between the GTPase domain, see ...
1-181 2.02e-58

Dynamin central region; This is the stalk region which lies between the GTPase domain, see pfam00350, and the pleckstrin homology (PH) domain, see pfam00169. This region dimerizes in a cross-like fashion forming a dynamin dimer in which the two G-domains are oriented in opposite directions.


Pssm-ID: 460033  Cd Length: 287  Bit Score: 187.73  E-value: 2.02e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LJB_A          1 EDENEKMFFLIDKVNAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGREL 80
Cdd:pfam01031 106 SDPAEKGKFLLQLITKFNQDFKNLIDGESEISTNELSGGARIRYIFNEIFPKSLEKIDPLENLSDEEIRTAIRNSRGIRL 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LJB_A         81 PGFVNYRTFETIVKQQIKALEEPAVDMLhtvtDMVRLAFTDVSIK---NFEEFFNLHRTAKSKIEDIRAEQEREGEKLIR 157
Cdd:pfam01031 186 PLFVPEKAFELLVKQQIKRLEEPALKCV----ELVYEELERIIHKctpELKRFPNLRERIKEVVEDLLRERLEPTEKMIR 261
                         170       180
                  ....*....|....*....|....*
3LJB_A        158 LHFQMEQ-IVYCQDQVYRGALQKVR 181
Cdd:pfam01031 262 SLIEMELaYINTNHPDFIGGLNAVR 286
GED smart00302
Dynamin GTPase effector domain;
206-271 1.43e-20

Dynamin GTPase effector domain;


Pssm-ID: 128597  Cd Length: 92  Bit Score: 83.44  E-value: 1.43e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
3LJB_A         206 DSSMEEIFQHLMAYHQEASKRISSHIPLIIQFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERSDT 271
Cdd:smart00302   3 DSELEEIKSLVKSYFTIVSKTLADQVPKAIMYLLVNESKDSLQNELLALLYKEELLDELLEEDPEI 68
GED pfam02212
Dynamin GTPase effector domain;
206-271 4.85e-20

Dynamin GTPase effector domain;


Pssm-ID: 460495  Cd Length: 91  Bit Score: 82.17  E-value: 4.85e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
3LJB_A        206 DSSMEEIFQHLMAYHQEASKRISSHIPLIIQFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERSDT 271
Cdd:pfam02212   2 ESETEEIRSLINSYFNIVRKTIADQIPKAIMHFLVNESKESLQKELLQKLYKSELLDELLKEDPEI 67
 
Name Accession Description Interval E-value
Dynamin_M pfam01031
Dynamin central region; This is the stalk region which lies between the GTPase domain, see ...
1-181 2.02e-58

Dynamin central region; This is the stalk region which lies between the GTPase domain, see pfam00350, and the pleckstrin homology (PH) domain, see pfam00169. This region dimerizes in a cross-like fashion forming a dynamin dimer in which the two G-domains are oriented in opposite directions.


Pssm-ID: 460033  Cd Length: 287  Bit Score: 187.73  E-value: 2.02e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LJB_A          1 EDENEKMFFLIDKVNAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGREL 80
Cdd:pfam01031 106 SDPAEKGKFLLQLITKFNQDFKNLIDGESEISTNELSGGARIRYIFNEIFPKSLEKIDPLENLSDEEIRTAIRNSRGIRL 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LJB_A         81 PGFVNYRTFETIVKQQIKALEEPAVDMLhtvtDMVRLAFTDVSIK---NFEEFFNLHRTAKSKIEDIRAEQEREGEKLIR 157
Cdd:pfam01031 186 PLFVPEKAFELLVKQQIKRLEEPALKCV----ELVYEELERIIHKctpELKRFPNLRERIKEVVEDLLRERLEPTEKMIR 261
                         170       180
                  ....*....|....*....|....*
3LJB_A        158 LHFQMEQ-IVYCQDQVYRGALQKVR 181
Cdd:pfam01031 262 SLIEMELaYINTNHPDFIGGLNAVR 286
GED smart00302
Dynamin GTPase effector domain;
206-271 1.43e-20

Dynamin GTPase effector domain;


Pssm-ID: 128597  Cd Length: 92  Bit Score: 83.44  E-value: 1.43e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
3LJB_A         206 DSSMEEIFQHLMAYHQEASKRISSHIPLIIQFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERSDT 271
Cdd:smart00302   3 DSELEEIKSLVKSYFTIVSKTLADQVPKAIMYLLVNESKDSLQNELLALLYKEELLDELLEEDPEI 68
GED pfam02212
Dynamin GTPase effector domain;
206-271 4.85e-20

Dynamin GTPase effector domain;


Pssm-ID: 460495  Cd Length: 91  Bit Score: 82.17  E-value: 4.85e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
3LJB_A        206 DSSMEEIFQHLMAYHQEASKRISSHIPLIIQFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERSDT 271
Cdd:pfam02212   2 ESETEEIRSLINSYFNIVRKTIADQIPKAIMHFLVNESKESLQKELLQKLYKSELLDELLKEDPEI 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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