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Conserved domains on  [gi|346651978|pdb|3RAC|A]
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Chain A, Histidine-tRNA ligase

Protein Classification

ATP phosphoribosyltransferase regulatory subunit( domain architecture ID 11211362)

ATP phosphoribosyltransferase regulatory subunit is required for the first step of histidine biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tRNA-synt_His pfam13393
Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP ...
 28-359 8.08e-90

Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP phosphoribosyltransferase regulatory subunits.


:

Pssm-ID: 433170 [Multi-domain]  Cd Length: 309  Bit Score: 272.54  E-value: 8.08e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A         28 GMQDGYPDFAKRRRAVETRLLSFVEDAGYEPVTSGLFEYVDTLLRArSPESSRDWIRLFDGGGDAVALRPEMTPSIARMA 107
Cdd:pfam13393   1 GIRDLLPPEARRIEELRRRLLDLFRSWGYELVMPPLLEYLDSLLTG-TGADLDQTFKLVDQSGRLLGLRADITPQVARID 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        108 APRVAAGRtPIRWCYCERVYRRTDDpaslswASGKAAESTQVGIERIGEeASVDVDMDVLRLLHEASAAAGVRHHRIVVS 187
Cdd:pfam13393  80 AHRLNRPG-PLRLCYAGSVLRTRPK------GLGRSREPLQVGAELIGH-AGIEADAEIISLLLEALAAAGVPGVTLDLG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        188 HARLVPRLLDALGISASLSRAFLACLTSGNYVQFRELWQLHAAkdvdllanlltwSPAERDAAKRSREAS--DRELEALL 265
Cdd:pfam13393 152 HVGLVRALLEAAGLSEALEEALRAALQRKDAAELAELAAEAGL------------PPALRRALLALPDLYggPEVLDEAR 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        266 RDAVDPRAAADVRDAWRYLCRLAEALHDSglasDVVTFDLALHRELDYYTGLVFEMFAPGVGAPIAQGGRYDELLAQFGA 345
Cdd:pfam13393 220 AALPGLPALQEALDELEALAALLEALGDG----VRLTFDLAELRGYEYYTGIVFAAYAPGVGEPLARGGRYDDLGAAFGR 295

                         330
                  ....*....|....
3RAC_A        346 GAPAVGFAFEVERV 359
Cdd:pfam13393 296 ARPATGFSLDLEAL 309
 
Name Accession Description Interval E-value
tRNA-synt_His pfam13393
Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP ...
 28-359 8.08e-90

Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP phosphoribosyltransferase regulatory subunits.


Pssm-ID: 433170 [Multi-domain]  Cd Length: 309  Bit Score: 272.54  E-value: 8.08e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A         28 GMQDGYPDFAKRRRAVETRLLSFVEDAGYEPVTSGLFEYVDTLLRArSPESSRDWIRLFDGGGDAVALRPEMTPSIARMA 107
Cdd:pfam13393   1 GIRDLLPPEARRIEELRRRLLDLFRSWGYELVMPPLLEYLDSLLTG-TGADLDQTFKLVDQSGRLLGLRADITPQVARID 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        108 APRVAAGRtPIRWCYCERVYRRTDDpaslswASGKAAESTQVGIERIGEeASVDVDMDVLRLLHEASAAAGVRHHRIVVS 187
Cdd:pfam13393  80 AHRLNRPG-PLRLCYAGSVLRTRPK------GLGRSREPLQVGAELIGH-AGIEADAEIISLLLEALAAAGVPGVTLDLG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        188 HARLVPRLLDALGISASLSRAFLACLTSGNYVQFRELWQLHAAkdvdllanlltwSPAERDAAKRSREAS--DRELEALL 265
Cdd:pfam13393 152 HVGLVRALLEAAGLSEALEEALRAALQRKDAAELAELAAEAGL------------PPALRRALLALPDLYggPEVLDEAR 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        266 RDAVDPRAAADVRDAWRYLCRLAEALHDSglasDVVTFDLALHRELDYYTGLVFEMFAPGVGAPIAQGGRYDELLAQFGA 345
Cdd:pfam13393 220 AALPGLPALQEALDELEALAALLEALGDG----VRLTFDLAELRGYEYYTGIVFAAYAPGVGEPLARGGRYDDLGAAFGR 295

                         330
                  ....*....|....
3RAC_A        346 GAPAVGFAFEVERV 359
Cdd:pfam13393 296 ARPATGFSLDLEAL 309
HisZ COG3705
ATP phosphoribosyltransferase regulatory subunit HisZ [Amino acid transport and metabolism];
33-366 1.33e-76

ATP phosphoribosyltransferase regulatory subunit HisZ [Amino acid transport and metabolism];


Pssm-ID: 442919 [Multi-domain]  Cd Length: 312  Bit Score: 238.92  E-value: 1.33e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       33 YPDFAKRRRAVETRLLSFVEDAGYEPVTSGLFEYVDTLLRARSPESSRDWIRLFDGGGDAVALRPEMTPSIARMAAPRVA 112
Cdd:COG3705   1 LPEEAARKEELRRRLLDVFRSWGYELVEPPLLEYLDSLLTGSGADLDLQTFKLVDQLGRTLGLRPDMTPQVARIAATRLA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A      113 AGRTPIRWCYCERVYRRTDDPAslswasGKAAESTQVGIERIGEeASVDVDMDVLRLLHEASAAAGVRHHRIVVSHARLV 192
Cdd:COG3705  81 NRPGPLRLCYAGNVFRTRPSGL------GRSREFLQAGAELIGH-AGLEADAEVIALALEALKAAGLEDFTLDLGHVGLF 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A      193 PRLLDALGISASLSRAFLACLTSGNYVQFRELwqlhaakdvdllANLLTWSPAERDAAKR------SREASDReLEALLR 266
Cdd:COG3705 154 RALLEALGLSEEQREELRRALARKDAVELEEL------------LAELGLSEELAEALLAlpelygGEEVLAR-ARALLL 220

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A      267 DAvdpraaaDVRDAWRYLCRLAEALHDSGLASDVvTFDLALHRELDYYTGLVFEMFAPGVGAPIAQGGRYDELLAQFGAG 346
Cdd:COG3705 221 DA-------AIRAALDELEALAEALAARGPDVRL-TFDLSELRGYDYYTGIVFEAYAPGVGDPLARGGRYDGLLAAFGRA 292

                       330       340
                ....*....|....*....|
3RAC_A      347 APAVGFAFEVERVMAVLEAQ 366
Cdd:COG3705 293 RPATGFSLDLDRLLRALPAA 312
hisZ PRK12292
ATP phosphoribosyltransferase regulatory subunit; Provisional
 26-368 9.18e-70

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 237043 [Multi-domain]  Cd Length: 391  Bit Score: 223.97  E-value: 9.18e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        26 PPGMQDGYPDFAKRRRAVETRLLSFVEDAGYEPVTSGLFEYVDTLLRARSPESSRDWIRLFD-GGGDAVALRPEMTPSIA 104
Cdd:PRK12292   6 PEGIRDLLPEEARKIEEIRRRLLDLFRRWGYEEVITPTLEYLDTLLAGGGAILDLRTFKLVDqLSGRTLGLRPDMTAQIA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       105 RMAAPRVAAGRTPIRWCYCERVYRRTDDpaslswASGKAAESTQVGIERIGEeASVDVDMDVLRLLHEASAAAGVRHHRI 184
Cdd:PRK12292  86 RIAATRLANRPGPLRLCYAGNVFRAQER------GLGRSREFLQSGVELIGD-AGLEADAEVILLLLEALKALGLPNFTL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       185 VVSHARLVPRLLDALGISASLSRAFLACLTSGNYVQFRELWQLHAAKDVDLLANLLtwspaerdaakRSReaSDRE-LEA 263
Cdd:PRK12292 159 DLGHVGLFRALLEAAGLSEELEEVLRRALANKDYVALEELVLDLSEELRDALLALP-----------RLR--GGREvLEE 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       264 LLRDAVDPRAAADVRDawryLCRLAEALHDSGLASDVvTFDLALHRELDYYTGLVFEMFAPGVGAPIAQGGRYDELLAQF 343
Cdd:PRK12292 226 ARKLLPSLPIKRALDE----LEALAEALEKYGYGIPL-SLDLGLLRHLDYYTGIVFEGYVDGVGNPIASGGRYDDLLGRF 300

                        330       340
                 ....*....|....*....|....*
3RAC_A       344 GAGAPAVGFAFEVERVMAVLEAQEE 368
Cdd:PRK12292 301 GRARPATGFSLDLDRLLELQLELPV 325
hisZ_biosyn_reg TIGR00443
ATP phosphoribosyltransferase, regulatory subunit; Apparant second copies of histidyl-tRNA ...
 34-364 1.11e-67

ATP phosphoribosyltransferase, regulatory subunit; Apparant second copies of histidyl-tRNA synthetase, found in Bacillus subtilis, Synechocystis sp., Aquifex aeolicus, and others, are in fact a regulatory subunit of ATP phosphoribosyltransferase, and usually encoded by a gene adjacent to that encoding the catalytic subunit. [Amino acid biosynthesis, Histidine family]


Pssm-ID: 273081 [Multi-domain]  Cd Length: 313  Bit Score: 215.94  E-value: 1.11e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A         34 PDFAKRRRAVETRLLSFVEDAGYEPVTSGLFEYVDTLLrARSPESSRDWIRLFDGGGDAVALRPEMTPSIARMAAPRVAA 113
Cdd:TIGR00443   5 PEEAARKEEIERQLQDVFRSWGYQEIITPTLEYLDTLS-AGSGILNEDLFKLFDQLGRVLGLRPDMTAPIARLVSTRLRD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        114 GRTPIRWCYCERVYRRTDDPAslswasGKAAESTQVGIERIGEeASVDVDMDVLRLLHEASAAAGVRHHRIVVSHARLVP 193
Cdd:TIGR00443  84 RPLPLRLCYAGNVFRTNESGG------GRSREFTQAGVELIGA-GGPAADAEVIALLIEALKALGLKDFKIELGHVGLVR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        194 RLLDALGISASLSRAFLACLTSGNYVQFRELWQlHAAKDVDLLANLLTWSpaerdaakrsREASDRE--LEALLRDAVDP 271
Cdd:TIGR00443 157 ALLEEAGLPEEAREALREALARKDLVALEELVA-ELGLSPEVRERLLALP----------RLRGDGEevLEEARALAGSE 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        272 RAAAdvrdAWRYLCRLAEALHDSGLaSDVVTFDLALHRELDYYTGLVFEMFAPGVGAPIAQGGRYDELLAQFGAGAPAVG 351
Cdd:TIGR00443 226 TAEA----ALDELEAVLELLEARGV-EEYISLDLGLVRGYHYYTGLIFEGYAPGLGAPLAGGGRYDELLGRFGRPLPATG 300

                         330
                  ....*....|...
3RAC_A        352 FAFEVERVMAVLE 364
Cdd:TIGR00443 301 FALNLERLLEALT 313
HisRS-like_core cd00773
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. ...
 37-364 6.62e-54

Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. This domain is also found at the C-terminus of eukaryotic GCN2 protein kinase and at the N-terminus of the ATP phosphoribosyltransferase accessory subunit, HisZ. HisZ along with HisG catalyze the first reaction in histidine biosynthesis. HisZ is found only in a subset of bacteria and differs from HisRS in lacking a C-terminal anti-codon binding domain.


Pssm-ID: 238396 [Multi-domain]  Cd Length: 261  Bit Score: 178.57  E-value: 6.62e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       37 AKRRRAVETRLLSFVEDAGYEPVTSGLFEYVDTLLRARSPESSRDWIRLFDGGGDAVALRPEMTPSIARMAAPRVAAGRT 116
Cdd:cd00773   2 AALRRYIEDTLREVFERYGYEEIDTPVFEYTELFLRKSGDEVSKEMYRFKDKGGRDLALRPDLTAPVARAVAENLLSLPL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A      117 PIRWCYCERVYRRtDDPaslswASGKAAESTQVGIERIGEEaSVDVDMDVLRLLHEASAAAGVRHHRIVVSHARLVPRLL 196
Cdd:cd00773  82 PLKLYYIGPVFRY-ERP-----QKGRYREFYQVGVEIIGSD-SPLADAEVIALAVEILEALGLKDFQIKINHRGILDGIA 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A      197 DALGisaslsraflacltsgnyvqfrelwqlhaakdvdllanlltwspaerdaakrsreaSDRELEALLRDAVDPRAAAD 276
Cdd:cd00773 155 GLLE--------------------------------------------------------DREEYIERLIDKLDKEALAH 178

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A      277 VRDAWRYLCRLAealhdsglASDVVTFDLALHRELDYYTGLVFEMFAPGVGA--PIAQGGRYDELLAQFGAGA-PAVGFA 353
Cdd:cd00773 179 LEKLLDYLEALG--------VDIKYSIDLSLVRGLDYYTGIVFEAVADGLGAqgSIAGGGRYDGLLEEFGGEDvPAVGFA 250

                       330
                ....*....|.
3RAC_A      354 FEVERVMAVLE 364
Cdd:cd00773 251 IGLERLLLALE 261
 
Name Accession Description Interval E-value
tRNA-synt_His pfam13393
Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP ...
 28-359 8.08e-90

Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP phosphoribosyltransferase regulatory subunits.


Pssm-ID: 433170 [Multi-domain]  Cd Length: 309  Bit Score: 272.54  E-value: 8.08e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A         28 GMQDGYPDFAKRRRAVETRLLSFVEDAGYEPVTSGLFEYVDTLLRArSPESSRDWIRLFDGGGDAVALRPEMTPSIARMA 107
Cdd:pfam13393   1 GIRDLLPPEARRIEELRRRLLDLFRSWGYELVMPPLLEYLDSLLTG-TGADLDQTFKLVDQSGRLLGLRADITPQVARID 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        108 APRVAAGRtPIRWCYCERVYRRTDDpaslswASGKAAESTQVGIERIGEeASVDVDMDVLRLLHEASAAAGVRHHRIVVS 187
Cdd:pfam13393  80 AHRLNRPG-PLRLCYAGSVLRTRPK------GLGRSREPLQVGAELIGH-AGIEADAEIISLLLEALAAAGVPGVTLDLG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        188 HARLVPRLLDALGISASLSRAFLACLTSGNYVQFRELWQLHAAkdvdllanlltwSPAERDAAKRSREAS--DRELEALL 265
Cdd:pfam13393 152 HVGLVRALLEAAGLSEALEEALRAALQRKDAAELAELAAEAGL------------PPALRRALLALPDLYggPEVLDEAR 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        266 RDAVDPRAAADVRDAWRYLCRLAEALHDSglasDVVTFDLALHRELDYYTGLVFEMFAPGVGAPIAQGGRYDELLAQFGA 345
Cdd:pfam13393 220 AALPGLPALQEALDELEALAALLEALGDG----VRLTFDLAELRGYEYYTGIVFAAYAPGVGEPLARGGRYDDLGAAFGR 295

                         330
                  ....*....|....
3RAC_A        346 GAPAVGFAFEVERV 359
Cdd:pfam13393 296 ARPATGFSLDLEAL 309
HisZ COG3705
ATP phosphoribosyltransferase regulatory subunit HisZ [Amino acid transport and metabolism];
33-366 1.33e-76

ATP phosphoribosyltransferase regulatory subunit HisZ [Amino acid transport and metabolism];


Pssm-ID: 442919 [Multi-domain]  Cd Length: 312  Bit Score: 238.92  E-value: 1.33e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       33 YPDFAKRRRAVETRLLSFVEDAGYEPVTSGLFEYVDTLLRARSPESSRDWIRLFDGGGDAVALRPEMTPSIARMAAPRVA 112
Cdd:COG3705   1 LPEEAARKEELRRRLLDVFRSWGYELVEPPLLEYLDSLLTGSGADLDLQTFKLVDQLGRTLGLRPDMTPQVARIAATRLA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A      113 AGRTPIRWCYCERVYRRTDDPAslswasGKAAESTQVGIERIGEeASVDVDMDVLRLLHEASAAAGVRHHRIVVSHARLV 192
Cdd:COG3705  81 NRPGPLRLCYAGNVFRTRPSGL------GRSREFLQAGAELIGH-AGLEADAEVIALALEALKAAGLEDFTLDLGHVGLF 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A      193 PRLLDALGISASLSRAFLACLTSGNYVQFRELwqlhaakdvdllANLLTWSPAERDAAKR------SREASDReLEALLR 266
Cdd:COG3705 154 RALLEALGLSEEQREELRRALARKDAVELEEL------------LAELGLSEELAEALLAlpelygGEEVLAR-ARALLL 220

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A      267 DAvdpraaaDVRDAWRYLCRLAEALHDSGLASDVvTFDLALHRELDYYTGLVFEMFAPGVGAPIAQGGRYDELLAQFGAG 346
Cdd:COG3705 221 DA-------AIRAALDELEALAEALAARGPDVRL-TFDLSELRGYDYYTGIVFEAYAPGVGDPLARGGRYDGLLAAFGRA 292

                       330       340
                ....*....|....*....|
3RAC_A      347 APAVGFAFEVERVMAVLEAQ 366
Cdd:COG3705 293 RPATGFSLDLDRLLRALPAA 312
hisZ PRK12292
ATP phosphoribosyltransferase regulatory subunit; Provisional
 26-368 9.18e-70

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 237043 [Multi-domain]  Cd Length: 391  Bit Score: 223.97  E-value: 9.18e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        26 PPGMQDGYPDFAKRRRAVETRLLSFVEDAGYEPVTSGLFEYVDTLLRARSPESSRDWIRLFD-GGGDAVALRPEMTPSIA 104
Cdd:PRK12292   6 PEGIRDLLPEEARKIEEIRRRLLDLFRRWGYEEVITPTLEYLDTLLAGGGAILDLRTFKLVDqLSGRTLGLRPDMTAQIA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       105 RMAAPRVAAGRTPIRWCYCERVYRRTDDpaslswASGKAAESTQVGIERIGEeASVDVDMDVLRLLHEASAAAGVRHHRI 184
Cdd:PRK12292  86 RIAATRLANRPGPLRLCYAGNVFRAQER------GLGRSREFLQSGVELIGD-AGLEADAEVILLLLEALKALGLPNFTL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       185 VVSHARLVPRLLDALGISASLSRAFLACLTSGNYVQFRELWQLHAAKDVDLLANLLtwspaerdaakRSReaSDRE-LEA 263
Cdd:PRK12292 159 DLGHVGLFRALLEAAGLSEELEEVLRRALANKDYVALEELVLDLSEELRDALLALP-----------RLR--GGREvLEE 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       264 LLRDAVDPRAAADVRDawryLCRLAEALHDSGLASDVvTFDLALHRELDYYTGLVFEMFAPGVGAPIAQGGRYDELLAQF 343
Cdd:PRK12292 226 ARKLLPSLPIKRALDE----LEALAEALEKYGYGIPL-SLDLGLLRHLDYYTGIVFEGYVDGVGNPIASGGRYDDLLGRF 300

                        330       340
                 ....*....|....*....|....*
3RAC_A       344 GAGAPAVGFAFEVERVMAVLEAQEE 368
Cdd:PRK12292 301 GRARPATGFSLDLDRLLELQLELPV 325
hisZ_biosyn_reg TIGR00443
ATP phosphoribosyltransferase, regulatory subunit; Apparant second copies of histidyl-tRNA ...
 34-364 1.11e-67

ATP phosphoribosyltransferase, regulatory subunit; Apparant second copies of histidyl-tRNA synthetase, found in Bacillus subtilis, Synechocystis sp., Aquifex aeolicus, and others, are in fact a regulatory subunit of ATP phosphoribosyltransferase, and usually encoded by a gene adjacent to that encoding the catalytic subunit. [Amino acid biosynthesis, Histidine family]


Pssm-ID: 273081 [Multi-domain]  Cd Length: 313  Bit Score: 215.94  E-value: 1.11e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A         34 PDFAKRRRAVETRLLSFVEDAGYEPVTSGLFEYVDTLLrARSPESSRDWIRLFDGGGDAVALRPEMTPSIARMAAPRVAA 113
Cdd:TIGR00443   5 PEEAARKEEIERQLQDVFRSWGYQEIITPTLEYLDTLS-AGSGILNEDLFKLFDQLGRVLGLRPDMTAPIARLVSTRLRD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        114 GRTPIRWCYCERVYRRTDDPAslswasGKAAESTQVGIERIGEeASVDVDMDVLRLLHEASAAAGVRHHRIVVSHARLVP 193
Cdd:TIGR00443  84 RPLPLRLCYAGNVFRTNESGG------GRSREFTQAGVELIGA-GGPAADAEVIALLIEALKALGLKDFKIELGHVGLVR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        194 RLLDALGISASLSRAFLACLTSGNYVQFRELWQlHAAKDVDLLANLLTWSpaerdaakrsREASDRE--LEALLRDAVDP 271
Cdd:TIGR00443 157 ALLEEAGLPEEAREALREALARKDLVALEELVA-ELGLSPEVRERLLALP----------RLRGDGEevLEEARALAGSE 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        272 RAAAdvrdAWRYLCRLAEALHDSGLaSDVVTFDLALHRELDYYTGLVFEMFAPGVGAPIAQGGRYDELLAQFGAGAPAVG 351
Cdd:TIGR00443 226 TAEA----ALDELEAVLELLEARGV-EEYISLDLGLVRGYHYYTGLIFEGYAPGLGAPLAGGGRYDELLGRFGRPLPATG 300

                         330
                  ....*....|...
3RAC_A        352 FAFEVERVMAVLE 364
Cdd:TIGR00443 301 FALNLERLLEALT 313
HisRS-like_core cd00773
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. ...
 37-364 6.62e-54

Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. This domain is also found at the C-terminus of eukaryotic GCN2 protein kinase and at the N-terminus of the ATP phosphoribosyltransferase accessory subunit, HisZ. HisZ along with HisG catalyze the first reaction in histidine biosynthesis. HisZ is found only in a subset of bacteria and differs from HisRS in lacking a C-terminal anti-codon binding domain.


Pssm-ID: 238396 [Multi-domain]  Cd Length: 261  Bit Score: 178.57  E-value: 6.62e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       37 AKRRRAVETRLLSFVEDAGYEPVTSGLFEYVDTLLRARSPESSRDWIRLFDGGGDAVALRPEMTPSIARMAAPRVAAGRT 116
Cdd:cd00773   2 AALRRYIEDTLREVFERYGYEEIDTPVFEYTELFLRKSGDEVSKEMYRFKDKGGRDLALRPDLTAPVARAVAENLLSLPL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A      117 PIRWCYCERVYRRtDDPaslswASGKAAESTQVGIERIGEEaSVDVDMDVLRLLHEASAAAGVRHHRIVVSHARLVPRLL 196
Cdd:cd00773  82 PLKLYYIGPVFRY-ERP-----QKGRYREFYQVGVEIIGSD-SPLADAEVIALAVEILEALGLKDFQIKINHRGILDGIA 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A      197 DALGisaslsraflacltsgnyvqfrelwqlhaakdvdllanlltwspaerdaakrsreaSDRELEALLRDAVDPRAAAD 276
Cdd:cd00773 155 GLLE--------------------------------------------------------DREEYIERLIDKLDKEALAH 178

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A      277 VRDAWRYLCRLAealhdsglASDVVTFDLALHRELDYYTGLVFEMFAPGVGA--PIAQGGRYDELLAQFGAGA-PAVGFA 353
Cdd:cd00773 179 LEKLLDYLEALG--------VDIKYSIDLSLVRGLDYYTGIVFEAVADGLGAqgSIAGGGRYDGLLEEFGGEDvPAVGFA 250

                       330
                ....*....|.
3RAC_A      354 FEVERVMAVLE 364
Cdd:cd00773 251 IGLERLLLALE 261
HisS COG0124
Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Histidyl-tRNA ...
 25-367 4.08e-43

Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Histidyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439894 [Multi-domain]  Cd Length: 422  Bit Score: 154.89  E-value: 4.08e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       25 RPPGMQDGYPDFAKRRRAVETRLLSFVEDAGYEPVTSGLFEYVDTLLRArspeSSRDWI-----RLFDGGGDAVALRPEM 99
Cdd:COG0124   6 APRGTRDILPEESAKWQYVEDTIREVFERYGFQEIRTPIFEYTELFARK----IGEDIVekemyTFEDRGGRSLTLRPEG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A      100 TPSIARMAAPRVAAGRTPIRWCYCERVYRRtDDPASlswasGKAAESTQVGIERIGEeASVDVDMDVLRLLHEASAAAGV 179
Cdd:COG0124  82 TAPVARAVAEHGNELPFPFKLYYIGPVFRY-ERPQK-----GRYRQFHQFGVEVIGS-DSPLADAEVIALAADLLKALGL 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A      180 RHHRIVVSHarlvprlldaLGISASLSRAFLACLTSGNYVQFRElwQLHAAKDVDLLANLLtwspaeRDAAkRSREASDR 259
Cdd:COG0124 155 KDFTLEINS----------RGLPEERAEALLRYLDKLDKIGHED--VLDEDSQRRLETNPL------RAIL-DSKGPDCQ 215

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A      260 ELEALLRDAVDPRAAADVRDaWRYLCRLAEALhdsGLAsdvVTFDLALHRELDYYTGLVFEMFAPGVGAP--IAQGGRYD 337
Cdd:COG0124 216 EVLADAPKLLDYLGEEGLAH-FEEVLELLDAL---GIP---YVIDPRLVRGLDYYTGTVFEIVTDGLGAQgsVCGGGRYD 288

                       330       340       350
                ....*....|....*....|....*....|.
3RAC_A      338 ELLAQFG-AGAPAVGFAFEVERVMAVLEAQE 367
Cdd:COG0124 289 GLVEQLGgPPTPAVGFAIGLERLLLLLEELG 319
hisS TIGR00442
histidyl-tRNA synthetase; This model finds a histidyl-tRNA synthetase in every completed ...
 25-367 5.23e-39

histidyl-tRNA synthetase; This model finds a histidyl-tRNA synthetase in every completed genome. Apparent second copies from Bacillus subtilis, Synechocystis sp., and Aquifex aeolicus are slightly shorter, more closely related to each other than to other hisS proteins, and actually serve as regulatory subunits for an enzyme of histidine biosynthesis. They were excluded from the seed alignment and score much lower than do single copy histidyl-tRNA synthetases of other genomes not included in the seed alignment. These putative second copies of HisS score below the trusted cutoff. The regulatory protein kinase GCN2 of Saccharomyces cerevisiae (YDR283c), and related proteins from other species designated eIF-2 alpha kinase, have a domain closely related to histidyl-tRNA synthetase that may serve to detect and respond to uncharged tRNA(his), an indicator of amino acid starvation; these regulatory proteins are not orthologous and so score below the noise cutoff. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273080 [Multi-domain]  Cd Length: 404  Bit Score: 143.39  E-value: 5.23e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A         25 RPPGMQDGYPDFAKRRRAVETRLLSFVEDAGYEPVTSGLFEYVDTLLRARSPESsrDWI-----RLFDGGGDAVALRPEM 99
Cdd:TIGR00442   2 KPRGTRDFLPEEMIKWQYIEETIREVFERYGFKEIRTPIFEYTELFKRKVGEET--DIVskemyTFKDKGGRSLTLRPEG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        100 TPSIARMAAPRVAAGRTPIRWCYCERVYRRtDDPASlswasGKAAESTQVGIERIGEEaSVDVDMDVLRLLHEASAAAGV 179
Cdd:TIGR00442  80 TAPVARAVIENKLLLPKPFKLYYIGPMFRY-ERPQK-----GRYRQFHQFGVEVIGSD-SPLADAEIIALAADILKELGL 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        180 RHHRIVVSHarlvprlldaLGISASLSRAFLACLtsgNYVQfrelwQLHAAKDVDLLANLLTwSPAERDAAKRSREASDR 259
Cdd:TIGR00442 153 KDFTLEINS----------LGILEGRLEYREALI---RYLD-----KHKDKLGEDSVRRLEK-NPLRILDSKNEKIQELL 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        260 ELEALLRDAVDPRAAADVRDawryLCRLAEALhdsglasDV-VTFDLALHRELDYYTGLVFEMFAPGVGAP--IAQGGRY 336
Cdd:TIGR00442 214 KNAPKILDFLCEESRAHFEE----LKELLDAL-------GIpYKIDPSLVRGLDYYTGTVFEFVTDDLGAQgsICGGGRY 282

                         330       340       350
                  ....*....|....*....|....*....|..
3RAC_A        337 DELLAQF-GAGAPAVGFAFEVERVMAVLEAQE 367
Cdd:TIGR00442 283 DGLVEELgGPPTPAVGFAIGIERLILLLEELG 314
PRK12421 PRK12421
ATP phosphoribosyltransferase regulatory subunit; Provisional
 26-371 9.22e-34

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 237098  Cd Length: 392  Bit Score: 128.93  E-value: 9.22e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        26 PPGMQDGYPDFAKRRRAVETRLLSFVEDAGYEPVTSGLFEYVDTLLRARSPESSRDWIRLFDG-GGDAVALRPEMTPSIA 104
Cdd:PRK12421  10 PDGVADVLPEEAQKIERLRRRLLDLFASRGYQLVMPPLIEYLESLLTGAGQDLKLQTFKLIDQlSGRLMGVRADITPQVA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       105 RMAApRVAAGRTPIRWCYCERVYRRTddPASLSwasgKAAESTQVGIERIGEeASVDVDMDVLRLLHEASAAAGVRHHRI 184
Cdd:PRK12421  90 RIDA-HLLNREGVARLCYAGSVLHTL--PQGLF----GSRTPLQLGAELYGH-AGIEADLEIIRLMLGLLRNAGVPALHL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       185 VVSHARLVPRLLDALGISASlsraflacltsgnyvQFRELWQLHAAKDVD----LLANLLTWSPAERDAAKRSREASDre 260
Cdd:PRK12421 162 DLGHVGIFRRLAELAGLSPE---------------EEEELFDLLQRKALPelaeVCQNLGVGSDLRRMFYALARLNGG-- 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       261 LEALLRDA-VDPRAAADVRDAWRYLCRLAEALHDSGLASDVvTFDLALHRELDYYTGLVFEMFAPGVGAPIAQGGRYDEL 339
Cdd:PRK12421 225 LEALDRALsVLALQDAAIRQALDELKTLAAHLKNRWPELPV-SIDLAELRGYHYHTGLVFAAYIPGRGQALARGGRYDGI 303

                        330       340       350
                 ....*....|....*....|....*....|..
3RAC_A       340 LAQFGAGAPAVGFAFEVERVMAVLEAQEEGEG 371
Cdd:PRK12421 304 GEAFGRARPATGFSMDLKELLALQFLEEEAGA 335
hisZ PRK12295
ATP phosphoribosyltransferase regulatory subunit; Provisional
 39-365 1.43e-28

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 183413 [Multi-domain]  Cd Length: 373  Bit Score: 114.26  E-value: 1.43e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        39 RRRAVETRLLSFVEDAGYEPVTSGLFEYVDTLLRaRSPESSRDWIRLF-DGGGDAVALRPEMTPSIARMAapRVAAGRTP 117
Cdd:PRK12295   6 ASAAAAEALLASFEAAGAVRVDPPILQPAEPFLD-LSGEDIRRRIFVTsDENGEELCLRPDFTIPVCRRH--IATAGGEP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       118 IRWCYCERVYRRtddpaslswASGKAAESTQVGIERIGEEASVDVDMDVLRLLHEASAAAGVRHHRIVVSHARLVPRLLD 197
Cdd:PRK12295  83 ARYAYLGEVFRQ---------RRDRASEFLQAGIESFGRADPAAADAEVLALALEALAALGPGDLEVRLGDVGLFAALVD 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       198 ALGIS----ASLSRAF---------LACLTSGNYVQF-RELWQLHAAKDVDLLANLLTW-------------SPAE---- 246
Cdd:PRK12295 154 ALGLPpgwkRRLLRHFgrprsldalLARLAGPRVDPLdEHAGVLAALADEAAARALVEDlmsiagispvggrSPAEiarr 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       247 -------RDAAKRSREASDReLEALLRDAVDPRAAA------------DVRDAWRYLCRLAEALHDSGLASDVVTFDLAL 307
Cdd:PRK12295 234 llekaalAAAARLPAEALAV-LERFLAISGPPDAALaalralaadaglDLDAALDRFEARLAALAARGIDLERLRFSASF 312

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
3RAC_A       308 HRELDYYTGLVFEMFAPGVG-APIAQGGRYDELLAQFGAGA--PAVGFAFEVERVMAVLEA 365
Cdd:PRK12295 313 GRPLDYYTGFVFEIRAAGNGdPPLAGGGRYDGLLTRLGAGEpiPAVGFSIWLDRLAALGGA 373
PLN02972 PLN02972
Histidyl-tRNA synthetase
 25-368 5.49e-21

Histidyl-tRNA synthetase


Pssm-ID: 215525 [Multi-domain]  Cd Length: 763  Bit Score: 94.57  E-value: 5.49e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        25 RPPGMQDGYPDFAKRRRAVETRLLSFVEDA----GYEPVTSGLFEYVDTLLrARSPESSRDWIRLFDGGGDAVALRPEMT 100
Cdd:PLN02972 325 RLPKIPKGTRDFAKEQMAIREKAFSIITSVfkrhGATALDTPVFELRETLM-GKYGEDSKLIYDLADQGGELCSLRYDLT 403

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       101 PSIARMAAprvAAGRTPIRWCYCERVYRRtDDPASlswasGKAAESTQVGIERIGEEASVDVDMDVLRLLHEASAAAGVR 180
Cdd:PLN02972 404 VPFARYVA---MNGITSFKRYQIAKVYRR-DNPSK-----GRYREFYQCDFDIAGVYEPMGPDFEIIKVLTELLDELDIG 474

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       181 HHRIVVSHARLVPRLLDALGISASLSRAFLACLTSGNYVQFRELWQLH------AAKDVDLLANLLtwspaerdaakRSR 254
Cdd:PLN02972 475 TYEVKLNHRKLLDGMLEICGVPPEKFRTICSSIDKLDKQSFEQVKKEMveekglSNETADKIGNFV-----------KER 543

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       255 EASDRELEALLRDAVDPRAAADVRDAWRYLCRLAEALHDSGlASDVVTFDLALHRELDYYTGLVFEMFAPG--VGApIAQ 332
Cdd:PLN02972 544 GPPLELLSKLRQEGSEFLGNASSRAALDELEIMFKALEKSK-AIGKIVFDLSLARGLDYYTGVIYEAVFKGaqVGS-IAA 621

                        330       340       350
                 ....*....|....*....|....*....|....*..
3RAC_A       333 GGRYDELLAQFGAG-APAVGFAFEVERVMAVLEAQEE 368
Cdd:PLN02972 622 GGRYDNLVGMFSGKqVPAVGVSLGIERVFAIMEQQEE 658
PLN02530 PLN02530
histidine-tRNA ligase
 26-354 3.21e-14

histidine-tRNA ligase


Pssm-ID: 178145 [Multi-domain]  Cd Length: 487  Bit Score: 73.62  E-value: 3.21e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        26 PPGMQDGYP-DFAKRR------RAVeTRLLSFVE-DAgyePVTSGlfeyvDTLLRARSPESSRDWIRLF-DGGGDAVALR 96
Cdd:PLN02530  73 PKGTRDFPPeDMRLRNwlfdhfREV-SRLFGFEEvDA---PVLES-----EELYIRKAGEEITDQLYNFeDKGGRRVALR 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        97 PEMTPSIARMAAPRVAAGRTPIRWC---YCERVYRRTddpaslswaSGKAAESTQ-----VGIERIGEEA---------- 158
Cdd:PLN02530 144 PELTPSLARLVLQKGKSLSLPLKWFaigQCWRYERMT---------RGRRREHYQwnmdiIGVPGVEAEAellaaivtff 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       159 ------SVDVDMDV--LRLLHEASAAAGVRHHR-----IVVSHARLVPR-----LLDALGISASLSRAFLACLTsgnyvq 220
Cdd:PLN02530 215 krvgitSSDVGIKVssRKVLQAVLKSYGIPEESfapvcVIVDKLEKLPReeiekELDTLGVSEEAIEGILDVLS------ 288

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       221 frelwqlhaAKDVDllanlltwspaerdaakrsreasdrELEALLRDAVDprAAADVRDawryLCRLAEALhdsGLAsDV 300
Cdd:PLN02530 289 ---------LKSLD-------------------------DLEALLGADSE--AVADLKQ----LFSLAEAY---GYQ-DW 324

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
3RAC_A       301 VTFDLALHRELDYYTGLVFEMF-APGVGAPIAQGGRYDELLAQFGA-GAPAVGFAF 354
Cdd:PLN02530 325 LVFDASVVRGLAYYTGIVFEGFdRAGKLRAICGGGRYDRLLSTFGGeDTPACGFGF 380
PRK12420 PRK12420
histidyl-tRNA synthetase; Provisional
 28-368 7.69e-11

histidyl-tRNA synthetase; Provisional


Pssm-ID: 237097 [Multi-domain]  Cd Length: 423  Bit Score: 63.21  E-value: 7.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        28 GMQDGYPDFAKRRRAVETRLLSFVEDAGYEPVTSGLFEYVDTLLR--ARSPESSRDWIRLFDGGGDAVALRPEMTPSIAR 105
Cdd:PRK12420   9 GTKDYLPEEQVLRNKIKRALEDVFERYGCKPLETPTLNMYELMSSkyGGGDEILKEIYTLTDQGKRDLALRYDLTIPFAK 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       106 MAA--PRVaagRTPIRWCYCERVYRrtDDPASLswasGKAAESTQVGIERIGEEaSVDVDMDVLRLLHEASAAAGVRHHr 183
Cdd:PRK12420  89 VVAmnPNI---RLPFKRYEIGKVFR--DGPIKQ----GRFREFIQCDVDIVGVE-SVMAEAELMSMAFELFRRLNLEVT- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       184 IVVSHARLVPRLLDALGISASLSRAFLACLTS----GNYVQFRELwqLHAAKDVDLLANLLTWSPAERDAA-KRSREASD 258
Cdd:PRK12420 158 IQYNNRKLLNGILQAIGIPTELTSDVILSLDKiekiGIDGVRKDL--LERGISEEMADTICNTVLSCLQLSiADFKEAFN 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       259 RELEAllrdavdpRAAADVRDAWRYLCRLaealhdsGLaSDVVTFDLALHRELDYYTGLVFEMFAPG--VGAPIAQGGRY 336
Cdd:PRK12420 236 NPLVA--------EGVNELQQLQQYLIAL-------GI-NENCIFNPFLARGLTMYTGTVYEIFLKDgsITSSIGSGGRY 299

                        330       340       350
                 ....*....|....*....|....*....|....*
3RAC_A       337 DELLAQF---GAGAPAVGFAFEVERVMAVLEAQEE 368
Cdd:PRK12420 300 DNIIGAFrgdDMNYPTVGISFGLDVIYTALSQKET 334
syh CHL00201
histidine-tRNA synthetase; Provisional
 28-364 9.17e-06

histidine-tRNA synthetase; Provisional


Pssm-ID: 164576 [Multi-domain]  Cd Length: 430  Bit Score: 47.20  E-value: 9.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        28 GMQDGYPDFAKRRRAVETRLLSFVEDAGYEPVTSGLFEYVDTLLRARSPES---SRDWIRLFDGGGDAVALRPEMTPSIA 104
Cdd:CHL00201   9 GTKDILPDEINYWQFIHDKALTLLSLANYSEIRTPIFENSSLYDRGIGETTdivNKEMYRFTDRSNRDITLRPEGTAGIV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       105 R-MAAPRVAAGRTPIRWCYCERVYRrTDDPASlswasGKAAESTQVGIERIGeeaSVDVDMDVlRLLHEASAaagvrhhr 183
Cdd:CHL00201  89 RaFIENKMDYHSNLQRLWYSGPMFR-YERPQS-----GRQRQFHQLGIEFIG---SIDARADT-EVIHLAMQ-------- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       184 iVVSHARLVPRLLDALGISASLSRaflacltSGNYVQFRE-LWQLHAAKDVDLlANLLTWSPAERDAAKRSREASDRELE 262
Cdd:CHL00201 151 -IFNELQVKNLILDINSIGKLEDR-------QSYQLKLVEyLSQYQDDLDTDS-QNRLYSNPIRILDSKNLKTQEILDGA 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       263 ALLRDAVDPRAAADVRDAWRYLCRLAealhdsglasdvVTFDL--ALHRELDYYTGLVFEM--FAPGVGAPIAQGGRYDE 338
Cdd:CHL00201 222 PKISDFLSLESTEHFYDVCTYLNLLN------------IPYKInyKLVRGLDYYNDTAFEIktLSSNGQDTICGGGRYDS 289

                        330       340
                 ....*....|....*....|....*..
3RAC_A       339 LLAQFGAGA-PAVGFAFEVERVMAVLE 364
Cdd:CHL00201 290 LIHQLGGPKtPAVGCAIGLERLLLIAK 316
hisZ PRK12293
ATP phosphoribosyltransferase regulatory subunit; Provisional
 37-353 7.84e-04

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 183411  Cd Length: 281  Bit Score: 40.75  E-value: 7.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A        37 AKRRRAVETRLLSFVEDAGYEPVTSGLFEYvdtlLRARSPESSRDWIRLFDGGGDAVALRPEMTPSIARMAAPRVAAGRT 116
Cdd:PRK12293  19 AKLKREIENVASEILYENGFEEIVTPFFSY----HQHQSIADEKELIRFSDEKNHQISLRADSTLDVVRIVTKRLGRSTE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       117 PIRWCYCERVYRRtddPASlswasgkaaESTQVGIERIGEEASVDVDMDVLRLLHEASAAAGVRhhrivVSHARlVPRLL 196
Cdd:PRK12293  95 HKKWFYIQPVFRY---PSN---------EIYQIGAELIGEEDLSEILNIAAEIFEELELEPILQ-----ISNIK-IPKLV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RAC_A       197 dalgisASLSRAFLACLTSGNYVQFRelwqlhaAKDVDLLANLLtwspaerdaakrsREASDRELEALLrdavdPRAAAD 276
Cdd:PRK12293 157 ------AEILGLDIEVFKKGQIEKLL-------AQNVPWLNKLV-------------RIKTLEDLDEVI-----ELVPDE 205

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
3RAC_A       277 VRDAWRYLCRLAEalhdsGLASDVVTFDLALHRELDYYTGLVFEMFAPgvGAPIAQGGRYDellaqfGAGAPAVGFA 353
Cdd:PRK12293 206 IKEELEKLKELAE-----SIKYENLVIAPLYYAKMRYYDDLFFRFFDG--NSTLASGGNYE------IDGISSSGFA 269
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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