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Conserved domains on  [gi|390980892|pdb|3V0R|A]
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Chain A, Major allergen Alt a 1

Protein Classification

Alt_A1 domain-containing protein( domain architecture ID 10191029)

Alt_A1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Alt_A1 cd12798
Alternaria alternata allergen Alt a 1; Alt a 1 defines a new homologous protein family with ...
 1-127 3.52e-54

Alternaria alternata allergen Alt a 1; Alt a 1 defines a new homologous protein family with unknown function exclusively found in fungi. The unique structure of Alt a 1 contains intramolecular disulfide bonds that are conserved among the Alt a 1 homologs. Residues reported to be IgE antibody-binding epitopes are exposed through dimerization via a conserved disulfide bond and hydrophobic and polar interactions. Further mechanistic structure/function studies will give insight into immunologic studies directed toward new forms of immunotherapy for Alternaria species-sensitive allergic patients.


:

Pssm-ID: 213998  Cd Length: 132  Bit Score: 166.06  E-value: 3.52e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3V0R_A        1 MDTASCPVTTEGDYVWKISEFYGRKPEGTYYNSLGFNIKATNGgTLDFTCSAQADKLEDHKWYSCGEnSFMDFSFDSDRS 80
Cdd:cd12798   1 ACAAPAPQAATSDETIDISDFSGRKPEDGYIDSVSFNINGTND-TLNLTCSAQADGTFDSKIYSCGE-SFGDSAYSFELV 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
3V0R_A       81 -------GLLLKQKVSDDITYVATATLPNYCRAGGNGPKDFVCQGVADAYITLV 127
Cdd:cd12798  79 kgkeadyGLRLYHSVGPDIGLYGTADIPTYCHAGGNGPGDFICTQVADAYITLV 132
 
Name Accession Description Interval E-value
Alt_A1 cd12798
Alternaria alternata allergen Alt a 1; Alt a 1 defines a new homologous protein family with ...
 1-127 3.52e-54

Alternaria alternata allergen Alt a 1; Alt a 1 defines a new homologous protein family with unknown function exclusively found in fungi. The unique structure of Alt a 1 contains intramolecular disulfide bonds that are conserved among the Alt a 1 homologs. Residues reported to be IgE antibody-binding epitopes are exposed through dimerization via a conserved disulfide bond and hydrophobic and polar interactions. Further mechanistic structure/function studies will give insight into immunologic studies directed toward new forms of immunotherapy for Alternaria species-sensitive allergic patients.


Pssm-ID: 213998  Cd Length: 132  Bit Score: 166.06  E-value: 3.52e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3V0R_A        1 MDTASCPVTTEGDYVWKISEFYGRKPEGTYYNSLGFNIKATNGgTLDFTCSAQADKLEDHKWYSCGEnSFMDFSFDSDRS 80
Cdd:cd12798   1 ACAAPAPQAATSDETIDISDFSGRKPEDGYIDSVSFNINGTND-TLNLTCSAQADGTFDSKIYSCGE-SFGDSAYSFELV 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
3V0R_A       81 -------GLLLKQKVSDDITYVATATLPNYCRAGGNGPKDFVCQGVADAYITLV 127
Cdd:cd12798  79 kgkeadyGLRLYHSVGPDIGLYGTADIPTYCHAGGNGPGDFICTQVADAYITLV 132
AltA1 pfam16541
Alternaria alternata allergen 1; AltA1 is a family of fungal allergens. It shows a unique ...
 18-116 2.17e-21

Alternaria alternata allergen 1; AltA1 is a family of fungal allergens. It shows a unique beta-barrel comprising 11 beta-strands. There is structural evidence for the location of IgE antibody-binding epitopes. The crystal structure will allow efforts to promote immunotherapy for patients allergic to Alternaria species.


Pssm-ID: 435411  Cd Length: 107  Bit Score: 82.07  E-value: 2.17e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3V0R_A         18 ISEF-YGRKPEGTYYNSLGFNIKATNGGTLDFTCSAQADKLEDHKW----YSC--GENSFmDFSFDSDRS--GLLLKQKV 88
Cdd:pfam16541   1 ITDFdFFRTPAHNSWGSVSFNLSNTAAGGYTVSCSASSSQLSDFFYgdmvYTCdgGESTF-RFSLGTNRPtgGLALNQEW 79

                          90       100
                  ....*....|....*....|....*...
3V0R_A         89 SDDITYVATATLPNYCRAGGNGPKDFVC 116
Cdd:pfam16541  80 ACEGGFWGTGSVPTYCHAGGYGPRDVTC 107
 
Name Accession Description Interval E-value
Alt_A1 cd12798
Alternaria alternata allergen Alt a 1; Alt a 1 defines a new homologous protein family with ...
 1-127 3.52e-54

Alternaria alternata allergen Alt a 1; Alt a 1 defines a new homologous protein family with unknown function exclusively found in fungi. The unique structure of Alt a 1 contains intramolecular disulfide bonds that are conserved among the Alt a 1 homologs. Residues reported to be IgE antibody-binding epitopes are exposed through dimerization via a conserved disulfide bond and hydrophobic and polar interactions. Further mechanistic structure/function studies will give insight into immunologic studies directed toward new forms of immunotherapy for Alternaria species-sensitive allergic patients.


Pssm-ID: 213998  Cd Length: 132  Bit Score: 166.06  E-value: 3.52e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3V0R_A        1 MDTASCPVTTEGDYVWKISEFYGRKPEGTYYNSLGFNIKATNGgTLDFTCSAQADKLEDHKWYSCGEnSFMDFSFDSDRS 80
Cdd:cd12798   1 ACAAPAPQAATSDETIDISDFSGRKPEDGYIDSVSFNINGTND-TLNLTCSAQADGTFDSKIYSCGE-SFGDSAYSFELV 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
3V0R_A       81 -------GLLLKQKVSDDITYVATATLPNYCRAGGNGPKDFVCQGVADAYITLV 127
Cdd:cd12798  79 kgkeadyGLRLYHSVGPDIGLYGTADIPTYCHAGGNGPGDFICTQVADAYITLV 132
AltA1 pfam16541
Alternaria alternata allergen 1; AltA1 is a family of fungal allergens. It shows a unique ...
 18-116 2.17e-21

Alternaria alternata allergen 1; AltA1 is a family of fungal allergens. It shows a unique beta-barrel comprising 11 beta-strands. There is structural evidence for the location of IgE antibody-binding epitopes. The crystal structure will allow efforts to promote immunotherapy for patients allergic to Alternaria species.


Pssm-ID: 435411  Cd Length: 107  Bit Score: 82.07  E-value: 2.17e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3V0R_A         18 ISEF-YGRKPEGTYYNSLGFNIKATNGGTLDFTCSAQADKLEDHKW----YSC--GENSFmDFSFDSDRS--GLLLKQKV 88
Cdd:pfam16541   1 ITDFdFFRTPAHNSWGSVSFNLSNTAAGGYTVSCSASSSQLSDFFYgdmvYTCdgGESTF-RFSLGTNRPtgGLALNQEW 79

                          90       100
                  ....*....|....*....|....*...
3V0R_A         89 SDDITYVATATLPNYCRAGGNGPKDFVC 116
Cdd:pfam16541  80 ACEGGFWGTGSVPTYCHAGGYGPRDVTC 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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