F-type proton-translocating ATP synthase (ATPH) and similar proteins; This family includes subunit c of chloroplast F-ATP synthase (F1Fo-ATP synthase), also known as ATP synthase F(o) sector subunit c (also called ATPase subunit III, F-type ATPase subunit c, or F-ATPase subunit c)and similar proteins. It is a proton-translocating subunit of the ATP synthase encoded by gene atpH.

                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
3V3C_J       2 LIAAASVIAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPEAEDKIRGTLLLSLAFMEALTIYGLVVALALLFAN 76
Cdd:cd18183  1 LISAASVIAAGLAVGLAAIGPGIGQGTAAGQAVEGIARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALALLFAN 75

ATP synthase subunit C;

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
3V3C_J         9 IAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPeaedKIRGTLLLSLAFMEALTIYGLVVAL 70
Cdd:pfam00137  1 LGAGLAVGLAALGSGIGQGIAGAAAIEAIARQP----KLFGKMLIGAALAEALAIYGLVVAL 58

F0F1 ATP synthase subunit C; Validated

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
3V3C_J        1 PLIAAASVIAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPEAEDKIRGTLLLSLAFMEALTIYGLVVALALLFANPF 78
Cdd:PRK07354  3 SITSAASVVAAALAVGLAAIGPGIGQGNAAGGAVEGIARQPEAEGKIRGTLLLSLAFMESLTIYGLVVALVLLFANPF 80

F0F1 ATP synthase subunit C; Provisional

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
3V3C_J        2 LIAAASVIAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPEAEDKIRGTLLLSLAFMEALTIYGLVVALALLFANPFV 79
Cdd:PRK13468  4 LIAVVSIIAAGLAVSIGAIGPALAEGRAVAAALDAIAQQPDAAGTISRTLFVGLAMIESMAIYCFVVAMILLFANPFW 81

membrane-bound Fo complex of F-ATP synthase, subunit c; Subunit c (also called subunit 9, or proteolipid) of the Fo complex of F-ATP synthase. The F-ATP synthase (also called FoF1-ATPase) consists of two structural domains: the F1 (factor one) complex containing the soluble catalytic core, and the Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F1 is composed of alpha, beta, gamma, delta, and epsilon subunits with a stoichiometry of 3:3:1:1:1, while Fo consists of the three subunits a, b, and c (1:2:10-14). An oligomeric ring of 10-14 c subunits (c-ring) make up the Fo rotor. The flux of protons though the ATPase channel (Fo) drives the rotation of the c-ring, which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the c-ring of Fo. The F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts, or in the plasma membranes of bacteria. The F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis. This group also includes F-ATP synthase that has also been found in the archaea Methanosarcina acetivorans.

                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....*
3V3C_J       8 VIAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPEAEDKIRGTLLLSLAFMEALTIYGLVVALAL 72
Cdd:cd18121  1 ALGAGLAIGLGAIGPGIGIGLAAAKALEGIARQPEAAGKIRTTMIIGLALIESLAIYALVIALIL 65

ATP synthase, membrane-bound Fo/Vo/Ao complexes, subunit c; Subunit c of the Fo/Vo/Ao complex is the main transmembrane subunit of F-, V- or A-type family of ATP synthases with rotary motors. These ion-transporting rotary ATP synthases are composed of two linked multi-subunit complexes: the F1, V1, and A1 complexes contains three copies each of the alpha and beta subunits that form the soluble catalytic core, which is involved in ATP synthesis/hydrolysis, and the Fo, Vo, or Ao (oligomycin sensitive) complex that forms the membrane-embedded proton pore. The F-ATP synthases (also called FoF1-ATPases) are found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts, or in the plasma membranes of bacteria. F-ATPases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis. The A-ATP synthase (AoA1-ATPases) is exclusively found in archaea and function like F-ATP synthase. Structurally, however, the A-ATP synthase is more closely related to the V-ATP synthase (vacuolar VoV1-ATPase), which is a proton-translocating ATPase responsible for acidification of eukaryotic intracellular compartments and for ATP synthesis in archaea and some eubacteria. Collectively, F-, V-, and A-type synthases can function in both ATP synthesis and hydrolysis modes.

                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....*
3V3C_J       8 VIAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPEAEDKIRGTLLLSLAFMEALTIYGLVVALAL 72
Cdd:cd00313  1 ALGAGLAIGLAAIGAGIGIGLAGAAALEAIARQPEAAGKIFTTMLIGLALIESLAIYGLVIAFLL 65

F-type proton-translocating ATPase subunit c (ATPE) and similar proteins; This family includes subunit c of F-ATP synthase (also called ATP synthase F(o) sector subunit c, F-type ATPase subunit c, or F-ATPase subunit c) and similar proteins. It is a proton-translocating subunit of the ATP synthase encoded by gene atpE.

                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....*
3V3C_J       8 VIAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPEAEDKIRGTLLLSLAFMEALTIYGLVVALAL 72
Cdd:cd18185  1 LIAAGLAIGLAAIGAAIGDGLVGSKFIEGIARQPELRGKLRTNMFIGVGLVEAVPIIAVVIALLL 65

F0F1 ATP synthase subunit C; Validated

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
3V3C_J         9 IAAGLAVgLASIGPGVGQGTAAGQAVEGIARQPEAEDKIRGTLLLSLAFMEALTIYGLVVALALLF 74
Cdd:PRK07159  34 IGAGLAM-IGVIGVGLGQGYAFGKAVEAIARNPEAQKQVFKLLFIGSAISETSSIYALLVAFILIF 98

F0F1 ATP synthase subunit C; Validated

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
3V3C_J        1 PLIAAASVIAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPEAEDKIRGTLLLSLAFMEALTIYGLVVALALLFANP 77
Cdd:PRK06876  2 ELIMGLTAIAAAIAIGLAALGAAIGIGLLGGKFLEGAARQPELIPMLQTKMFIGAGLVDAIPIIGVGIALLFLFANP 78

ATP synthase subunit C;

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
3V3C_J         9 IAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPeaedKIRGTLLLSLAFMEALTIYGLVVAL 70
Cdd:pfam00137  1 LGAGLAVGLAALGSGIGQGIAGAAAIEAIARQP----KLFGKMLIGAALAEALAIYGLVVAL 58

ATP synthase, F0 subunit c; This model describes the subunit c in F1/F0-ATP synthase, a membrane associated multisubunit complex found in bacteria and organelles of higher eukaryotes, namely, mitochondria and chloroplast. This enzyme is principally involved in the synthesis of ATP from ADP and inorganic phosphate by coupling the energy derived from the proton electrochemical gradient across the biological membrane. A brief description of this multisubunit enzyme complex: F1 and F0 represent two major clusters of subunits. The functional role of subunit c, which is the part of F0 cluster, has been delineated in-vitro reconstitution experiments. Overall experimental proof exists that demonstrate the electrochemical gradient is converted into a rotational torque that leads to ATP synthesis. [Energy metabolism, ATP-proton motive force interconversion]

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
3V3C_J        18 ASIGPGVGQGTAAGQAVEGIARQPEAEDKIRGTLLLSLAFMEALTIYGLVVALALLFA 75
Cdd:TIGR01260  1 AAIGAAIGIGILGGKFLESAARQPELKPLLRTTMFIGMGLVDAIPMIAVVIALILLFA 58

ATP synthase F(0) complex subunit C3 (ATP5G3) and similar proteins; ATP5G3 (also called ATP synthase lipid-binding protein, ATP synthase proteolipid P3, ATP synthase proton-transporting mitochondrial F(o) complex subunit C3, ATPase protein 9, or ATPase subunit c) transports protons across the inner mitochondrial membrane to the F1-ATPase protruding on the matrix side, resulting in the generation of ATP.

                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|...
3V3C_J       8 VIAAGLAVgLASIGPGVGQGTAAGQAVEGIARQPEAEDKIRGTLLLSLAFMEALTIYGLVVAL 70
Cdd:cd18182  2 YIGAGLAT-IGLAGAGIGIGNVFGSLINGVARNPSAKQQLFTYAILGFALTEAIGLFALMVAF 63

V-type ATP synthase subunit K; Validated

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
3V3C_J         5 AASVIAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPEaedkIRGTLLLSLAFMEALTIYGLVVALALLFA 75
Cdd:PRK06251  34 AGINIGAGLAVGLAAIGAGIAVGMAAAAGIGVLTERRD----MFGTVLIFVAIGEGIAVYGILFAVLMLFG 100

Membrane-bound Vo/Ao complexes of V/A-type ATP synthases, subunit c; Vo/Ao-ATP synthase subunit c. The V- and A-type family of ATPases are composed of two linked multi-subunit complexes: the V1 and A1 complexes contain three copies each of the alpha and beta subunits that form the soluble catalytic core, which is involved in ATP synthesis/hydrolysis, and the Vo or Ao complex that forms the membrane-embedded proton pore. The A-ATP synthase (AoA1-ATPases) is exclusively found in archaea and functions like the F-ATP synthase. Structurally, however, the A-ATP synthase is more closely related to the V-ATP synthase (vacuolar VoV1-ATPase), which is a proton-translocating ATPase responsible for acidification of eukaryotic intracellular compartments and for ATP synthesis in archaea and some eubacteria. The V- and A-type synthases can function in both ATP synthesis and hydrolysis modes. The V1 complex consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The Vo complex consists of five different subunits: a, c, c', c'', and d. The Ao/A1 complexes are composed of nine subunits in a stoichiometry of A(3):B(3):C:D:E:F:H(2):a:c(x). ATP is synthesized on the A3:B3 hexamer and the energy released during that process is transferred to the Ao complex, which consists of the C-terminal segment of subunit a and subunit c.

                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|..
3V3C_J       9 IAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPEaedkIRGTLLLSLAFMEALTIYGLVVAL 70
Cdd:cd18120  3 LGAALAVGLSCLGAGIAVGMVGAAAIGAIAEKPE----LFGKALIFVGLAEGLAIYGLIVAI 60