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Conserved domains on  [gi|491668233|pdb|4BIK|D]
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Chain D, Cd59 Glycoprotein

Protein Classification

Ly-6/uPAR domain-containing protein( domain architecture ID 10061478)

LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_CD59 cd23554
extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called ...
 2-71 2.83e-24

extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called 1F5 antigen, or 20 kDa homologous restriction factor, or HRF-20, or MAC-inhibitory protein (MAC-IP), or MEM43 antigen, or membrane attack complex inhibition factor (MACIF), or membrane inhibitor of reactive lysis (MIRL), or protectin) is an LY-6-like protein expressed in human lymphoid cells and inhibits the action of the complement membrane attack complex (MAC) on homologous cells. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. CD59 contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467084  Cd Length: 70  Bit Score: 86.22  E-value: 2.83e-24
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4BIK_D       2 LQCYNCPNPTADCKTAVNCSSDFDACLITKAGLQVYNKCWKFEHCNFNDVTTRLRENELTYYCCKKDLCN 71
Cdd:cd23554  1 LKCYNCPNPTSNCNTNVTCSSNLDACLIVKAGNRIYRQCWKYSDCNFDFISERFGESNFKYRCCQKDLCN 70
 
Name Accession Description Interval E-value
TFP_LU_ECD_CD59 cd23554
extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called ...
 2-71 2.83e-24

extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called 1F5 antigen, or 20 kDa homologous restriction factor, or HRF-20, or MAC-inhibitory protein (MAC-IP), or MEM43 antigen, or membrane attack complex inhibition factor (MACIF), or membrane inhibitor of reactive lysis (MIRL), or protectin) is an LY-6-like protein expressed in human lymphoid cells and inhibits the action of the complement membrane attack complex (MAC) on homologous cells. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. CD59 contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467084  Cd Length: 70  Bit Score: 86.22  E-value: 2.83e-24
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4BIK_D       2 LQCYNCPNPTADCKTAVNCSSDFDACLITKAGLQVYNKCWKFEHCNFNDVTTRLRENELTYYCCKKDLCN 71
Cdd:cd23554  1 LKCYNCPNPTSNCNTNVTCSSNLDACLIVKAGNRIYRQCWKYSDCNFDFISERFGESNFKYRCCQKDLCN 70
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 2-73 1.14e-10

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 52.15  E-value: 1.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4BIK_D          2 LQCYNCP-NPTADCKTAVNCSSDFDACLITKA-------GLQVYNKCWKFEHCNFNDVT-TRLRENELTYYCCKKDLCNF 72
Cdd:smart00134  1 LQCYSCTgNPDSSCSSEEECRSPDDVCLTVVAevisdsrGSVVYKGCATSPICPGSHGYeINLTIAFLKVSCCQTDLCNA 80


                  .
4BIK_D         73 N 73
Cdd:smart00134 81 A 81
 
Name Accession Description Interval E-value
TFP_LU_ECD_CD59 cd23554
extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called ...
 2-71 2.83e-24

extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called 1F5 antigen, or 20 kDa homologous restriction factor, or HRF-20, or MAC-inhibitory protein (MAC-IP), or MEM43 antigen, or membrane attack complex inhibition factor (MACIF), or membrane inhibitor of reactive lysis (MIRL), or protectin) is an LY-6-like protein expressed in human lymphoid cells and inhibits the action of the complement membrane attack complex (MAC) on homologous cells. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. CD59 contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467084  Cd Length: 70  Bit Score: 86.22  E-value: 2.83e-24
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4BIK_D       2 LQCYNCPNPTADCKTAVNCSSDFDACLITKAGLQVYNKCWKFEHCNFNDVTTRLRENELTYYCCKKDLCN 71
Cdd:cd23554  1 LKCYNCPNPTSNCNTNVTCSSNLDACLIVKAGNRIYRQCWKYSDCNFDFISERFGESNFKYRCCQKDLCN 70
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 2-73 1.14e-10

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 52.15  E-value: 1.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4BIK_D          2 LQCYNCP-NPTADCKTAVNCSSDFDACLITKA-------GLQVYNKCWKFEHCNFNDVT-TRLRENELTYYCCKKDLCNF 72
Cdd:smart00134  1 LQCYSCTgNPDSSCSSEEECRSPDDVCLTVVAevisdsrGSVVYKGCATSPICPGSHGYeINLTIAFLKVSCCQTDLCNA 80


                  .
4BIK_D         73 N 73
Cdd:smart00134 81 A 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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