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Conserved domains on  [gi|1995662295|pdb|4V4T|BY]
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Chain BY, 50S ribosomal protein 24

Protein Classification

uL24 family ribosomal protein( domain architecture ID 11246010)

uL24 family ribosomal protein is required for the assembly of different ribosomal subunits and are widely distributed among all living organisms.

Gene Ontology:  GO:0006412|GO:0003735|GO:0003723
PubMed:  24524803

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ribosomal_L26 pfam16906
Ribosomal proteins L26 eukaryotic, L24P archaeal; Ribosomal_L26 is a family of the 50S and the ...
 1-113 6.43e-42

Ribosomal proteins L26 eukaryotic, L24P archaeal; Ribosomal_L26 is a family of the 50S and the 60S ribosomal proteins from eukaryotes - L26 - and archaea - L25.


:

Pssm-ID: 465307 [Multi-domain]  Cd Length: 114  Bit Score: 133.79  E-value: 6.43e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4V4T_BY         1 SKQPDKQRKSQRRAPLHERHKQVRATLSADLREEYGQRNVRVNAGDTVEVLRGDFAGEEGEVINVDLDKAVIHVEDVTLE 80
Cdd:pfam16906   1 SSSRRKQRKAHFNAPSHIRRKLMSAPLSKELREKYGVRSLPIRKGDEVKVVRGDFKGREGKVVQVYRKKYRIHVEGVTRE 80

                          90       100       110
                  ....*....|....*....|....*....|...
4V4T_BY        81 KTDGEEVPRPLDTSNVRVTDLDLeDEKREARLE 113
Cdd:pfam16906  81 KANGTTVPVPIHPSKVVITKLKL-DKDRKKILE 112
 
Name Accession Description Interval E-value
Ribosomal_L26 pfam16906
Ribosomal proteins L26 eukaryotic, L24P archaeal; Ribosomal_L26 is a family of the 50S and the ...
 1-113 6.43e-42

Ribosomal proteins L26 eukaryotic, L24P archaeal; Ribosomal_L26 is a family of the 50S and the 60S ribosomal proteins from eukaryotes - L26 - and archaea - L25.


Pssm-ID: 465307 [Multi-domain]  Cd Length: 114  Bit Score: 133.79  E-value: 6.43e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4V4T_BY         1 SKQPDKQRKSQRRAPLHERHKQVRATLSADLREEYGQRNVRVNAGDTVEVLRGDFAGEEGEVINVDLDKAVIHVEDVTLE 80
Cdd:pfam16906   1 SSSRRKQRKAHFNAPSHIRRKLMSAPLSKELREKYGVRSLPIRKGDEVKVVRGDFKGREGKVVQVYRKKYRIHVEGVTRE 80

                          90       100       110
                  ....*....|....*....|....*....|...
4V4T_BY        81 KTDGEEVPRPLDTSNVRVTDLDLeDEKREARLE 113
Cdd:pfam16906  81 KANGTTVPVPIHPSKVVITKLKL-DKDRKKILE 112
rplX_A_E TIGR01080
ribosomal protein uL24, archaeal/eukaryotic form; This model represents the archaeal and ...
 1-113 2.93e-39

ribosomal protein uL24, archaeal/eukaryotic form; This model represents the archaeal and eukaryotic branch of the ribosomal protein L24p/L26e family. Bacterial and organellar forms are represented by related model TIGR01079. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273432  Cd Length: 114  Bit Score: 127.27  E-value: 2.93e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4V4T_BY         1 SKQPDKQRKSQRRAPLHERHKQVRATLSADLREEYGQRNVRVNAGDTVEVLRGDFAGEEGEVINVDLDKAVIHVEDVTLE 80
Cdd:TIGR01080   1 SKQPRKQRKALFTAPLHERRKLMSAPLSKELREKYGKRALPIRKGDEVRIVRGDFKGHEGKVSKVDRKRYRIYVEGVTKE 80

                          90       100       110
                  ....*....|....*....|....*....|...
4V4T_BY        81 KTDGEEVPRPLDTSNVRVTDLDLEDEKREARLE 113
Cdd:TIGR01080  81 KVDGTEVPVPLHPSNVMITKLHLDDEKRKKLLE 113
PTZ00194 PTZ00194
60S ribosomal protein L26; Provisional
 6-119 2.00e-21

60S ribosomal protein L26; Provisional


Pssm-ID: 185508  Cd Length: 143  Bit Score: 82.87  E-value: 2.00e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4V4T_BY        6 KQRKSQRRAPLHERHKQVRATLSADLREEYGQRNVRVNAGDTVEVLRGDFAGEEGEVINVDLDKAVIHVEDVTLEKTDGE 85
Cdd:PTZ00194  11 KARKAHFTAPSHLRRKLMSAPLSKELRAKYNVRSMPVRKDDEVMVVRGHHKGREGKVTAVYRKKWVIHIEKITREKANGE 90

                         90       100       110
                 ....*....|....*....|....*....|....
4V4T_BY       86 EVPRPLDTSNVRVTDLDLeDEKREARLESEDDSA 119
Cdd:PTZ00194  91 PVQIGIHPSNVIITKLKL-NKDRKAILERKARST 123
KOW_RPL26 cd06089
KOW motif of Ribosomal Protein L26; RPL26 and its bacterial paralogs RPL24 have a KOW motif at ...
 45-98 4.58e-13

KOW motif of Ribosomal Protein L26; RPL26 and its bacterial paralogs RPL24 have a KOW motif at their N terminal. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. RPL26 makes a very minor contributions to the biogenesis, structure, and function of 60s ribosomal subunits. However, RPL24 is essential to generate the first intermediate during 50s ribosomal subunits assembly. RPL26 have an extra-ribosomal function to enhances p53 translation after DNA damage.


Pssm-ID: 240513  Cd Length: 65  Bit Score: 59.07  E-value: 4.58e-13
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
4V4T_BY      45 GDTVEVLRGDFAGEEGEVINVDLDKAVIHVEDVTLEKTD-----------GEEVPRPLDTSNVRV 98
Cdd:cd06089   1 GDEVQVIRGKDKGKQGKVLKVDRKKNRVIVEGVNVVKKHvkpsqenpqggIIEVEAPIHISNVML 65
RplX COG0198
Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L24 ...
 45-96 1.04e-03

Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L24 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439968 [Multi-domain]  Cd Length: 104  Bit Score: 35.81  E-value: 1.04e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
4V4T_BY      45 GDTVEVLRGDFAGEEGEVINVDLDKAVIHVEDVTLEK---------TDG--EEVPRPLDTSNV 96
Cdd:COG0198   8 GDTVIVIAGKDKGKRGKVLKVLPKKNRVIVEGVNIVKkhqkpnqqnPQGgiIEKEAPIHISNV 70
KOW smart00739
KOW (Kyprides, Ouzounis, Woese) motif; Motif in ribosomal proteins, NusG, Spt5p, KIN17 and T54.
 45-66 3.26e-03

KOW (Kyprides, Ouzounis, Woese) motif; Motif in ribosomal proteins, NusG, Spt5p, KIN17 and T54.


Pssm-ID: 128978  Cd Length: 28  Bit Score: 32.69  E-value: 3.26e-03
                           10        20
                   ....*....|....*....|..
4V4T_BY         45 GDTVEVLRGDFAGEEGEVINVD 66
Cdd:smart00739   5 GDTVRVIAGPFKGKVGKVLEVD 26
 
Name Accession Description Interval E-value
Ribosomal_L26 pfam16906
Ribosomal proteins L26 eukaryotic, L24P archaeal; Ribosomal_L26 is a family of the 50S and the ...
 1-113 6.43e-42

Ribosomal proteins L26 eukaryotic, L24P archaeal; Ribosomal_L26 is a family of the 50S and the 60S ribosomal proteins from eukaryotes - L26 - and archaea - L25.


Pssm-ID: 465307 [Multi-domain]  Cd Length: 114  Bit Score: 133.79  E-value: 6.43e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4V4T_BY         1 SKQPDKQRKSQRRAPLHERHKQVRATLSADLREEYGQRNVRVNAGDTVEVLRGDFAGEEGEVINVDLDKAVIHVEDVTLE 80
Cdd:pfam16906   1 SSSRRKQRKAHFNAPSHIRRKLMSAPLSKELREKYGVRSLPIRKGDEVKVVRGDFKGREGKVVQVYRKKYRIHVEGVTRE 80

                          90       100       110
                  ....*....|....*....|....*....|...
4V4T_BY        81 KTDGEEVPRPLDTSNVRVTDLDLeDEKREARLE 113
Cdd:pfam16906  81 KANGTTVPVPIHPSKVVITKLKL-DKDRKKILE 112
rplX_A_E TIGR01080
ribosomal protein uL24, archaeal/eukaryotic form; This model represents the archaeal and ...
 1-113 2.93e-39

ribosomal protein uL24, archaeal/eukaryotic form; This model represents the archaeal and eukaryotic branch of the ribosomal protein L24p/L26e family. Bacterial and organellar forms are represented by related model TIGR01079. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273432  Cd Length: 114  Bit Score: 127.27  E-value: 2.93e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4V4T_BY         1 SKQPDKQRKSQRRAPLHERHKQVRATLSADLREEYGQRNVRVNAGDTVEVLRGDFAGEEGEVINVDLDKAVIHVEDVTLE 80
Cdd:TIGR01080   1 SKQPRKQRKALFTAPLHERRKLMSAPLSKELREKYGKRALPIRKGDEVRIVRGDFKGHEGKVSKVDRKRYRIYVEGVTKE 80

                          90       100       110
                  ....*....|....*....|....*....|...
4V4T_BY        81 KTDGEEVPRPLDTSNVRVTDLDLEDEKREARLE 113
Cdd:TIGR01080  81 KVDGTEVPVPLHPSNVMITKLHLDDEKRKKLLE 113
PTZ00194 PTZ00194
60S ribosomal protein L26; Provisional
 6-119 2.00e-21

60S ribosomal protein L26; Provisional


Pssm-ID: 185508  Cd Length: 143  Bit Score: 82.87  E-value: 2.00e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4V4T_BY        6 KQRKSQRRAPLHERHKQVRATLSADLREEYGQRNVRVNAGDTVEVLRGDFAGEEGEVINVDLDKAVIHVEDVTLEKTDGE 85
Cdd:PTZ00194  11 KARKAHFTAPSHLRRKLMSAPLSKELRAKYNVRSMPVRKDDEVMVVRGHHKGREGKVTAVYRKKWVIHIEKITREKANGE 90

                         90       100       110
                 ....*....|....*....|....*....|....
4V4T_BY       86 EVPRPLDTSNVRVTDLDLeDEKREARLESEDDSA 119
Cdd:PTZ00194  91 PVQIGIHPSNVIITKLKL-NKDRKAILERKARST 123
KOW_RPL26 cd06089
KOW motif of Ribosomal Protein L26; RPL26 and its bacterial paralogs RPL24 have a KOW motif at ...
 45-98 4.58e-13

KOW motif of Ribosomal Protein L26; RPL26 and its bacterial paralogs RPL24 have a KOW motif at their N terminal. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. RPL26 makes a very minor contributions to the biogenesis, structure, and function of 60s ribosomal subunits. However, RPL24 is essential to generate the first intermediate during 50s ribosomal subunits assembly. RPL26 have an extra-ribosomal function to enhances p53 translation after DNA damage.


Pssm-ID: 240513  Cd Length: 65  Bit Score: 59.07  E-value: 4.58e-13
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
4V4T_BY      45 GDTVEVLRGDFAGEEGEVINVDLDKAVIHVEDVTLEKTD-----------GEEVPRPLDTSNVRV 98
Cdd:cd06089   1 GDEVQVIRGKDKGKQGKVLKVDRKKNRVIVEGVNVVKKHvkpsqenpqggIIEVEAPIHISNVML 65
KOW pfam00467
KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, ...
 45-75 2.84e-06

KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, Woese) motif is found in a variety of ribosomal proteins and NusG.


Pssm-ID: 425698 [Multi-domain]  Cd Length: 32  Bit Score: 40.83  E-value: 2.84e-06
                          10        20        30
                  ....*....|....*....|....*....|.
4V4T_BY        45 GDTVEVLRGDFAGEEGEVINVDLDKAVIHVE 75
Cdd:pfam00467   2 GDVVRVIAGPFKGKVGKVVEVDDKKNRVLVE 32
KOW_NusG cd06091
NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; KOW_NusG motif ...
 42-75 3.40e-05

NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; KOW_NusG motif is one of the two domains of N-Utilization Substance G (NusG) a transcription elongation and Rho-termination factor in bacteria and archaea. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. The eukaryotic ortholog of NusG is Spt5 with multiple KOW motifs at its C-terminus.


Pssm-ID: 240515 [Multi-domain]  Cd Length: 56  Bit Score: 38.59  E-value: 3.40e-05
                        10        20        30
                ....*....|....*....|....*....|....
4V4T_BY      42 VNAGDTVEVLRGDFAGEEGEVINVDLDKAVIHVE 75
Cdd:cd06091   4 FEVGDTVRIISGPFAGFEGKVEEIDEEKGKVKVL 37
RplX COG0198
Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L24 ...
 45-96 1.04e-03

Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L24 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439968 [Multi-domain]  Cd Length: 104  Bit Score: 35.81  E-value: 1.04e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
4V4T_BY      45 GDTVEVLRGDFAGEEGEVINVDLDKAVIHVEDVTLEK---------TDG--EEVPRPLDTSNV 96
Cdd:COG0198   8 GDTVIVIAGKDKGKRGKVLKVLPKKNRVIVEGVNIVKkhqkpnqqnPQGgiIEKEAPIHISNV 70
KOW smart00739
KOW (Kyprides, Ouzounis, Woese) motif; Motif in ribosomal proteins, NusG, Spt5p, KIN17 and T54.
 45-66 3.26e-03

KOW (Kyprides, Ouzounis, Woese) motif; Motif in ribosomal proteins, NusG, Spt5p, KIN17 and T54.


Pssm-ID: 128978  Cd Length: 28  Bit Score: 32.69  E-value: 3.26e-03
                           10        20
                   ....*....|....*....|..
4V4T_BY         45 GDTVEVLRGDFAGEEGEVINVD 66
Cdd:smart00739   5 GDTVRVIAGPFKGKVGKVLEVD 26
KOW_Spt5_2 cd06082
KOW domain of Spt5, repeat 2; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 45-76 5.06e-03

KOW domain of Spt5, repeat 2; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


Pssm-ID: 240506  Cd Length: 51  Bit Score: 32.86  E-value: 5.06e-03
                        10        20        30
                ....*....|....*....|....*....|..
4V4T_BY      45 GDTVEVLRGDFAGEEGEVINVDLDKAVIHVED 76
Cdd:cd06082   4 GDNVEVIEGELKGLQGKVESVDGDIVTIMPKH 35
rpl24 CHL00141
ribosomal protein L24; Validated
 37-102 8.10e-03

ribosomal protein L24; Validated


Pssm-ID: 214374  Cd Length: 83  Bit Score: 33.08  E-value: 8.10e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
4V4T_BY       37 QRNVRVNAGDTVEVLRGDFAGEEGEVINVDLDKAVIHVEDVTLE------KTDGE--EVPR---PLDTSNVRVTDLD 102
Cdd:CHL00141   4 KKKMHVKIGDTVKIISGSDKGKIGEVLKIIKKSNKVIVKGINIKfkhikpNKENEvgEIKQfeaPIHSSNVMLYNEE 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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