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Conserved domains on  [gi|969813071|pdb|5FLX|X]
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Chain X, 40S RIBOSOMAL PROTEIN S23

Protein Classification

40S ribosomal protein S23( domain architecture ID 10015179)

40S ribosomal protein S23

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00067 PTZ00067
40S ribosomal S23; Provisional
 1-143 4.00e-93

40S ribosomal S23; Provisional


:

Pssm-ID: 185422  Cd Length: 143  Bit Score: 265.45  E-value: 4.00e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5FLX_X         1 MGKCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKK 80
Cdd:PTZ00067   1 MGKPRGLRAARKLRRHRRVNRWADKEYKKAHLGTRYKANPFGGASHAKGIVVEKIGIEAKQPNSAIRKCVRVQLIKNGKK 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
5FLX_X        81 ITAFVPNDGCLNFIEENDEVLVAGFGRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPRS 143
Cdd:PTZ00067  81 ITAFVPNDGCLNFINENDEVLVSGFGRSGHAVGDIPGVRFKVVKVAGVSLLALYKGKKEKPRN 143
 
Name Accession Description Interval E-value
PTZ00067 PTZ00067
40S ribosomal S23; Provisional
 1-143 4.00e-93

40S ribosomal S23; Provisional


Pssm-ID: 185422  Cd Length: 143  Bit Score: 265.45  E-value: 4.00e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5FLX_X         1 MGKCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKK 80
Cdd:PTZ00067   1 MGKPRGLRAARKLRRHRRVNRWADKEYKKAHLGTRYKANPFGGASHAKGIVVEKIGIEAKQPNSAIRKCVRVQLIKNGKK 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
5FLX_X        81 ITAFVPNDGCLNFIEENDEVLVAGFGRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPRS 143
Cdd:PTZ00067  81 ITAFVPNDGCLNFINENDEVLVSGFGRSGHAVGDIPGVRFKVVKVAGVSLLALYKGKKEKPRN 143
Ribosomal_S23 cd03367
S12-like family, 40S ribosomal protein S23 subfamily; S23 is located at the interface of the ...
 26-140 4.49e-80

S12-like family, 40S ribosomal protein S23 subfamily; S23 is located at the interface of the large and small ribosomal subunits of eukaryotes, adjacent to the decoding center. It interacts with domain III of the eukaryotic elongation factor 2 (eEF2), which catalyzes the translocation of the growing peptidyl-tRNA to the P site to make room for the next aminoacyl-tRNA at the A (acceptor) site. Through its interaction with eEF2, S23 may play an important role in translocation. Also members of this subfamily are the archaeal 30S ribosomal S12 proteins. Prokaryotic S12 is essential for maintenance of a pretranslocation state and, together with S13, functions as control element for the rRNA- and tRNA-driven movements of translocation. S12 and S23 are also implicated in translation accuracy. Antibiotics such as streptomycin bind S12/S23 and cause the ribosome to misread the genetic code.


Pssm-ID: 239465  Cd Length: 115  Bit Score: 231.39  E-value: 4.49e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5FLX_X       26 QYKKAHLGTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGF 105
Cdd:cd03367   1 RYKKRHLGTKYKADPLGGAPHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPGDGCLNFIDENDEVLVAGF 80

                        90       100       110
                ....*....|....*....|....*....|....*
5FLX_X      106 GRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKER 140
Cdd:cd03367  81 GRKGRAVGDIPGVRFKVVKVNGVSLLALFKGKKEK 115
Ribosom_S12_S23 pfam00164
Ribosomal protein S12/S23; This protein is known as S12 in bacteria and archaea and S23 in ...
 29-142 2.46e-60

Ribosomal protein S12/S23; This protein is known as S12 in bacteria and archaea and S23 in eukaryotes.


Pssm-ID: 395112  Cd Length: 114  Bit Score: 181.50  E-value: 2.46e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5FLX_X         29 KAHLGTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGFGRK 108
Cdd:pfam00164   1 RRLLGLKTKSPPLEGAPQARGVVLEKVTVEPKQPNSALRKCVRVRLIKNGKEVTAFIPGEGAIHFLQEHDEVLIRGGGGP 80

                          90       100       110
                  ....*....|....*....|....*....|....
5FLX_X        109 GHAVGDIPGVRFKVVKVANVSLLALYKGKKERPR 142
Cdd:pfam00164  81 GHAVGDLPGVRYKVVRVAGVSLQALSKYGAEKPK 114
uS12_E_A TIGR00982
ribosomal protein uS12, eukaryotic/archaeal form; This model represents eukaryotic and ...
 6-142 7.20e-56

ribosomal protein uS12, eukaryotic/archaeal form; This model represents eukaryotic and archaeal forms of ribosomal protein uS12. This protein was known previously as S23 in eukaryotes and as either S12 or S23 in the Archaea. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273377  Cd Length: 139  Bit Score: 171.21  E-value: 7.20e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5FLX_X          6 GLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFV 85
Cdd:TIGR00982   1 GLFAARKLKLKRKKFRWSDRRYKRRVLRLKEKADPLEGAPQARGIVLEKIGVEAKQPNSAIRKAVRVQLIKNGKVVTAFC 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
5FLX_X         86 PNDGCLNFIEENDEVLVAGF-GRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPR 142
Cdd:TIGR00982  81 PGDGAINFIDEHDEVIIEGIgGPKGRSMGDIPGVRYKVVKVNNVSLKELVKGRKEKPR 138
RpsL COG0048
Ribosomal protein S12 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S12 ...
 35-123 1.38e-08

Ribosomal protein S12 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S12 is part of the Pathway/BioSystem: Ribosome 30S subunit


Pssm-ID: 439818  Cd Length: 124  Bit Score: 49.82  E-value: 1.38e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5FLX_X       35 ALKANPFggashAKGIVLEKVGVEAKQPNSAIRKCVRVQLiKNGKKITAFVPNDGclNFIEENDEVLVAGfGRkghaVGD 114
Cdd:COG0048  23 ALKGCPQ-----KRGVCTRVYTTTPKKPNSALRKVARVRL-SNGIEVTAYIPGEG--HNLQEHSVVLVRG-GR----VKD 89


                ....*....
5FLX_X      115 IPGVRFKVV 123
Cdd:COG0048  90 LPGVRYHIV 98
 
Name Accession Description Interval E-value
PTZ00067 PTZ00067
40S ribosomal S23; Provisional
 1-143 4.00e-93

40S ribosomal S23; Provisional


Pssm-ID: 185422  Cd Length: 143  Bit Score: 265.45  E-value: 4.00e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5FLX_X         1 MGKCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKK 80
Cdd:PTZ00067   1 MGKPRGLRAARKLRRHRRVNRWADKEYKKAHLGTRYKANPFGGASHAKGIVVEKIGIEAKQPNSAIRKCVRVQLIKNGKK 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
5FLX_X        81 ITAFVPNDGCLNFIEENDEVLVAGFGRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPRS 143
Cdd:PTZ00067  81 ITAFVPNDGCLNFINENDEVLVSGFGRSGHAVGDIPGVRFKVVKVAGVSLLALYKGKKEKPRN 143
Ribosomal_S23 cd03367
S12-like family, 40S ribosomal protein S23 subfamily; S23 is located at the interface of the ...
 26-140 4.49e-80

S12-like family, 40S ribosomal protein S23 subfamily; S23 is located at the interface of the large and small ribosomal subunits of eukaryotes, adjacent to the decoding center. It interacts with domain III of the eukaryotic elongation factor 2 (eEF2), which catalyzes the translocation of the growing peptidyl-tRNA to the P site to make room for the next aminoacyl-tRNA at the A (acceptor) site. Through its interaction with eEF2, S23 may play an important role in translocation. Also members of this subfamily are the archaeal 30S ribosomal S12 proteins. Prokaryotic S12 is essential for maintenance of a pretranslocation state and, together with S13, functions as control element for the rRNA- and tRNA-driven movements of translocation. S12 and S23 are also implicated in translation accuracy. Antibiotics such as streptomycin bind S12/S23 and cause the ribosome to misread the genetic code.


Pssm-ID: 239465  Cd Length: 115  Bit Score: 231.39  E-value: 4.49e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5FLX_X       26 QYKKAHLGTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGF 105
Cdd:cd03367   1 RYKKRHLGTKYKADPLGGAPHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPGDGCLNFIDENDEVLVAGF 80

                        90       100       110
                ....*....|....*....|....*....|....*
5FLX_X      106 GRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKER 140
Cdd:cd03367  81 GRKGRAVGDIPGVRFKVVKVNGVSLLALFKGKKEK 115
rps12P PRK04211
30S ribosomal protein S12P; Reviewed
 5-142 2.43e-68

30S ribosomal protein S12P; Reviewed


Pssm-ID: 235257  Cd Length: 145  Bit Score: 202.87  E-value: 2.43e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5FLX_X         5 RGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAF 84
Cdd:PRK04211   6 NGLFAARKLKLKRKKFRWSDRRYKRRMLGLKEKADPLEGAPMARGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKQVTAF 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
5FLX_X        85 VPNDGCLNFIEENDEVLVAGF-GRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPR 142
Cdd:PRK04211  86 CPGDGAINFIDEHDEVVIEGIgGPKGRSMGDIPGVRYKVIKVNGVSLKELVKGKKEKPV 144
Ribosom_S12_S23 pfam00164
Ribosomal protein S12/S23; This protein is known as S12 in bacteria and archaea and S23 in ...
 29-142 2.46e-60

Ribosomal protein S12/S23; This protein is known as S12 in bacteria and archaea and S23 in eukaryotes.


Pssm-ID: 395112  Cd Length: 114  Bit Score: 181.50  E-value: 2.46e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5FLX_X         29 KAHLGTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGFGRK 108
Cdd:pfam00164   1 RRLLGLKTKSPPLEGAPQARGVVLEKVTVEPKQPNSALRKCVRVRLIKNGKEVTAFIPGEGAIHFLQEHDEVLIRGGGGP 80

                          90       100       110
                  ....*....|....*....|....*....|....
5FLX_X        109 GHAVGDIPGVRFKVVKVANVSLLALYKGKKERPR 142
Cdd:pfam00164  81 GHAVGDLPGVRYKVVRVAGVSLQALSKYGAEKPK 114
uS12_E_A TIGR00982
ribosomal protein uS12, eukaryotic/archaeal form; This model represents eukaryotic and ...
 6-142 7.20e-56

ribosomal protein uS12, eukaryotic/archaeal form; This model represents eukaryotic and archaeal forms of ribosomal protein uS12. This protein was known previously as S23 in eukaryotes and as either S12 or S23 in the Archaea. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273377  Cd Length: 139  Bit Score: 171.21  E-value: 7.20e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5FLX_X          6 GLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFV 85
Cdd:TIGR00982   1 GLFAARKLKLKRKKFRWSDRRYKRRVLRLKEKADPLEGAPQARGIVLEKIGVEAKQPNSAIRKAVRVQLIKNGKVVTAFC 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
5FLX_X         86 PNDGCLNFIEENDEVLVAGF-GRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPR 142
Cdd:TIGR00982  81 PGDGAINFIDEHDEVIIEGIgGPKGRSMGDIPGVRYKVVKVNNVSLKELVKGRKEKPR 138
Ribosomal_S12_like cd00319
Ribosomal protein S12-like family; composed of prokaryotic 30S ribosomal protein S12, ...
 33-137 5.38e-42

Ribosomal protein S12-like family; composed of prokaryotic 30S ribosomal protein S12, eukaryotic 40S ribosomal protein S23 and similar proteins. S12 and S23 are located at the interface of the large and small ribosomal subunits, adjacent to the decoding center. They play an important role in translocation during the peptide elongation step of protein synthesis. They are also involved in important RNA and protein interactions. Ribosomal protein S12 is essential for maintenance of a pretranslocation state and, together with S13, functions as a control element for the rRNA- and tRNA-driven movements of translocation. S23 interacts with domain III of the eukaryotic elongation factor 2 (eEF2), which catalyzes translocation. Mutations in S12 and S23 have been found to affect translational accuracy. Antibiotics such as streptomycin may also bind S12/S23 and cause the ribosome to misread the genetic code.


Pssm-ID: 238196  Cd Length: 95  Bit Score: 134.45  E-value: 5.38e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5FLX_X       33 GTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIkNGKKITAFVPNDGclNFIEENDEVLVAGFGRKghav 112
Cdd:cd00319   1 RKKSKVPALKGAPFRRGVCTVVRTVTPKKPNSALRKVAKVRLT-SGYEVTAYIPGEG--HNLQEHSVVLIRGGRVK---- 73

                        90       100
                ....*....|....*....|....*
5FLX_X      113 gDIPGVRFKVVKvaNVSLLALYKGK 137
Cdd:cd00319  74 -DLPGVRYHIVR--GVYDAAGVKDR 95
Ribosomal_S12 cd03368
S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the ...
 37-124 1.25e-11

S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit interactions. S12 is essential for maintenance of a pretranslocation state and, together with S13, functions as a control element for the rRNA- and tRNA-driven movements of translocation. Antibiotics such as streptomycin bind S12 and cause the ribosome to misread the genetic code.


Pssm-ID: 239466  Cd Length: 108  Bit Score: 57.53  E-value: 1.25e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5FLX_X       37 KANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLiKNGKKITAFVPNDGclNFIEENDEVLVAGfGRkghaVGDIP 116
Cdd:cd03368  18 KSPALEGCPQKKGVCLKVYTTTPKKPNSALRKVARVRL-SNGKEVTAYIPGEG--HNLQEHSVVLVRG-GR----VKDLP 89


                ....*...
5FLX_X      117 GVRFKVVK 124
Cdd:cd03368  90 GVRYHIVR 97
rps12 CHL00051
ribosomal protein S12
 34-124 2.41e-11

ribosomal protein S12


Pssm-ID: 176992  Cd Length: 123  Bit Score: 56.96  E-value: 2.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5FLX_X        34 TALKANPfggasHAKGIVLEKVGVEAKQPNSAIRKCVRVQLiKNGKKITAFVPNDGclNFIEENDEVLVAGfGRkghaVG 113
Cdd:CHL00051  22 PALRGCP-----QRRGTCTRVYTITPKKPNSALRKVARVRL-TSGFEITAYIPGIG--HNLQEHSVVLVRG-GR----VK 88

                         90
                 ....*....|.
5FLX_X       114 DIPGVRFKVVK 124
Cdd:CHL00051  89 DLPGVRYHIVR 99
RpsL COG0048
Ribosomal protein S12 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S12 ...
 35-123 1.38e-08

Ribosomal protein S12 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S12 is part of the Pathway/BioSystem: Ribosome 30S subunit


Pssm-ID: 439818  Cd Length: 124  Bit Score: 49.82  E-value: 1.38e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5FLX_X       35 ALKANPFggashAKGIVLEKVGVEAKQPNSAIRKCVRVQLiKNGKKITAFVPNDGclNFIEENDEVLVAGfGRkghaVGD 114
Cdd:COG0048  23 ALKGCPQ-----KRGVCTRVYTTTPKKPNSALRKVARVRL-SNGIEVTAYIPGEG--HNLQEHSVVLVRG-GR----VKD 89


                ....*....
5FLX_X      115 IPGVRFKVV 123
Cdd:COG0048  90 LPGVRYHIV 98
PTZ00115 PTZ00115
40S ribosomal protein S12; Provisional
 43-124 7.70e-05

40S ribosomal protein S12; Provisional


Pssm-ID: 240276  Cd Length: 290  Bit Score: 40.98  E-value: 7.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5FLX_X        43 GASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLiKNGKKITAFVPNDGclNFIEENDEVLVAGfGRkghaVGDIPGVRFKV 122
Cdd:PTZ00115 122 GAPQKKGICVKVRVQTPRKPNSGLRKVARVRL-STGRTVTVYIPGIG--HNLNTHSVVLVRG-GR----CKDVPGCNYKA 193


                 ..
5FLX_X       123 VK 124
Cdd:PTZ00115 194 VR 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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