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Conserved domains on  [gi|1784437736|pdb|5HOU|A]
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Chain A, Cellular tumor antigen p53,CREB-binding protein fusion protein

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-TAZ pfam02135
TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 ...
 94-161 8.50e-25

TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1. The zinc coordinating motif that is necessary for binding to target DNA sequences consists of HCCC.


:

Pssm-ID: 460457  Cd Length: 72  Bit Score: 91.29  E-value: 8.50e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
5HOU_A         94 HAHKCQRREQAngevrACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVC 161
Cdd:pfam02135  10 HASKCSAPGPG-----PCSLPNCRKMKRLLRHMATCKRGGGCPYPHCKRSRQLLRHAKNCKDEDCPVC 72
TAD2 pfam18521
Transactivation domain 2; This is a N-terminal transactivation domain (TAD) domain 2 found in ...
 38-62 1.37e-12

Transactivation domain 2; This is a N-terminal transactivation domain (TAD) domain 2 found in p53 proteins. In p53 two TAD domains are found termed TAD1 (residues 1-39) and TAD2 (residues 40-61), both of which have been shown to be able to independently activate gene transcription and are intrinsically disordered protein domains that adopt a helical conformation for at least part of their length when bound. This inherent flexibility allows the TADs to adapt to and bind a broad range of proteins. This entry describes TAD2 which can independently interact with Taz2 domain of the histone acetyltransferase p300. It has also been shown to bind to OB-fold domain of replication protein 70 A (RPA) as well as the pleckstrin homology (PH) domain of the p62 and Tfb1 subunits of human and yeast TFIIH.


:

Pssm-ID: 375947  Cd Length: 25  Bit Score: 58.61  E-value: 1.37e-12
                          10        20
                  ....*....|....*....|....*
5HOU_A         38 LPSQAMDDLMLSPDDIEQWFTEDPG 62
Cdd:pfam18521   1 LPSQAMDDLMLSPDDIEQWFTEDPG 25
P53_TAD pfam08563
P53 transactivation motif; The binding of the p53 transactivation domain by regulatory ...
 9-33 5.52e-09

P53 transactivation motif; The binding of the p53 transactivation domain by regulatory proteins regulates p53 transcription activation. This motif is comprised of a single amphipathic alpha helix and contains a highly conserved sequence.


:

Pssm-ID: 462520  Cd Length: 25  Bit Score: 49.09  E-value: 5.52e-09
                          10        20
                  ....*....|....*....|....*
5HOU_A          9 SDPSVEPPLSQETFSDLWKLLPENN 33
Cdd:pfam08563   1 SDLGLELPLSQETFSDLWNLLPPST 25
 
Name Accession Description Interval E-value
zf-TAZ pfam02135
TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 ...
 94-161 8.50e-25

TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1. The zinc coordinating motif that is necessary for binding to target DNA sequences consists of HCCC.


Pssm-ID: 460457  Cd Length: 72  Bit Score: 91.29  E-value: 8.50e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
5HOU_A         94 HAHKCQRREQAngevrACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVC 161
Cdd:pfam02135  10 HASKCSAPGPG-----PCSLPNCRKMKRLLRHMATCKRGGGCPYPHCKRSRQLLRHAKNCKDEDCPVC 72
ZnF_TAZ smart00551
TAZ zinc finger, present in p300 and CBP;
94-164 3.83e-18

TAZ zinc finger, present in p300 and CBP;


Pssm-ID: 214717  Cd Length: 79  Bit Score: 74.32  E-value: 3.83e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
5HOU_A          94 HAHKCQRREQAngevraCSLPHCRTMKNVLNHMTHCQAGKaCQVAHCASSRQIISHWKNCTRHDCPVCLPL 164
Cdd:smart00551  16 HARRCKAREAK------CQYPNCKTMKKLLRHMDSCKVRK-CKYGYCASCKQLWQHSKHCKDSNCPVCKCV 79
TAD2 pfam18521
Transactivation domain 2; This is a N-terminal transactivation domain (TAD) domain 2 found in ...
 38-62 1.37e-12

Transactivation domain 2; This is a N-terminal transactivation domain (TAD) domain 2 found in p53 proteins. In p53 two TAD domains are found termed TAD1 (residues 1-39) and TAD2 (residues 40-61), both of which have been shown to be able to independently activate gene transcription and are intrinsically disordered protein domains that adopt a helical conformation for at least part of their length when bound. This inherent flexibility allows the TADs to adapt to and bind a broad range of proteins. This entry describes TAD2 which can independently interact with Taz2 domain of the histone acetyltransferase p300. It has also been shown to bind to OB-fold domain of replication protein 70 A (RPA) as well as the pleckstrin homology (PH) domain of the p62 and Tfb1 subunits of human and yeast TFIIH.


Pssm-ID: 375947  Cd Length: 25  Bit Score: 58.61  E-value: 1.37e-12
                          10        20
                  ....*....|....*....|....*
5HOU_A         38 LPSQAMDDLMLSPDDIEQWFTEDPG 62
Cdd:pfam18521   1 LPSQAMDDLMLSPDDIEQWFTEDPG 25
P53_TAD pfam08563
P53 transactivation motif; The binding of the p53 transactivation domain by regulatory ...
 9-33 5.52e-09

P53 transactivation motif; The binding of the p53 transactivation domain by regulatory proteins regulates p53 transcription activation. This motif is comprised of a single amphipathic alpha helix and contains a highly conserved sequence.


Pssm-ID: 462520  Cd Length: 25  Bit Score: 49.09  E-value: 5.52e-09
                          10        20
                  ....*....|....*....|....*
5HOU_A          9 SDPSVEPPLSQETFSDLWKLLPENN 33
Cdd:pfam08563   1 SDLGLELPLSQETFSDLWNLLPPST 25
 
Name Accession Description Interval E-value
zf-TAZ pfam02135
TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 ...
 94-161 8.50e-25

TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1. The zinc coordinating motif that is necessary for binding to target DNA sequences consists of HCCC.


Pssm-ID: 460457  Cd Length: 72  Bit Score: 91.29  E-value: 8.50e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
5HOU_A         94 HAHKCQRREQAngevrACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVC 161
Cdd:pfam02135  10 HASKCSAPGPG-----PCSLPNCRKMKRLLRHMATCKRGGGCPYPHCKRSRQLLRHAKNCKDEDCPVC 72
ZnF_TAZ smart00551
TAZ zinc finger, present in p300 and CBP;
94-164 3.83e-18

TAZ zinc finger, present in p300 and CBP;


Pssm-ID: 214717  Cd Length: 79  Bit Score: 74.32  E-value: 3.83e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
5HOU_A          94 HAHKCQRREQAngevraCSLPHCRTMKNVLNHMTHCQAGKaCQVAHCASSRQIISHWKNCTRHDCPVCLPL 164
Cdd:smart00551  16 HARRCKAREAK------CQYPNCKTMKKLLRHMDSCKVRK-CKYGYCASCKQLWQHSKHCKDSNCPVCKCV 79
TAD2 pfam18521
Transactivation domain 2; This is a N-terminal transactivation domain (TAD) domain 2 found in ...
 38-62 1.37e-12

Transactivation domain 2; This is a N-terminal transactivation domain (TAD) domain 2 found in p53 proteins. In p53 two TAD domains are found termed TAD1 (residues 1-39) and TAD2 (residues 40-61), both of which have been shown to be able to independently activate gene transcription and are intrinsically disordered protein domains that adopt a helical conformation for at least part of their length when bound. This inherent flexibility allows the TADs to adapt to and bind a broad range of proteins. This entry describes TAD2 which can independently interact with Taz2 domain of the histone acetyltransferase p300. It has also been shown to bind to OB-fold domain of replication protein 70 A (RPA) as well as the pleckstrin homology (PH) domain of the p62 and Tfb1 subunits of human and yeast TFIIH.


Pssm-ID: 375947  Cd Length: 25  Bit Score: 58.61  E-value: 1.37e-12
                          10        20
                  ....*....|....*....|....*
5HOU_A         38 LPSQAMDDLMLSPDDIEQWFTEDPG 62
Cdd:pfam18521   1 LPSQAMDDLMLSPDDIEQWFTEDPG 25
P53_TAD pfam08563
P53 transactivation motif; The binding of the p53 transactivation domain by regulatory ...
 9-33 5.52e-09

P53 transactivation motif; The binding of the p53 transactivation domain by regulatory proteins regulates p53 transcription activation. This motif is comprised of a single amphipathic alpha helix and contains a highly conserved sequence.


Pssm-ID: 462520  Cd Length: 25  Bit Score: 49.09  E-value: 5.52e-09
                          10        20
                  ....*....|....*....|....*
5HOU_A          9 SDPSVEPPLSQETFSDLWKLLPENN 33
Cdd:pfam08563   1 SDLGLELPLSQETFSDLWNLLPPST 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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