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Conserved domains on  [gi|1784437744|pdb|5HPD|A]
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Chain A, CREB-binding protein,Cellular tumor antigen p53 fusion protein

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-TAZ pfam02135
TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 ...
 10-78 1.48e-18

TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1. The zinc coordinating motif that is necessary for binding to target DNA sequences consists of HCCC.


:

Pssm-ID: 460457  Cd Length: 72  Bit Score: 74.73  E-value: 1.48e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
5HPD_A         10 IQRCIQSLVHACQCRNAN---CSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCyHAKHCQENKCPV 78
Cdd:pfam02135   1 LQRWLLLLLHASKCSAPGpgpCSLPNCRKMKRLLRHMATCKRGGGCPYPHCKRSRQLLR-HAKNCKDEDCPV 71
TAD2 pfam18521
Transactivation domain 2; This is a N-terminal transactivation domain (TAD) domain 2 found in ...
 132-156 3.03e-13

Transactivation domain 2; This is a N-terminal transactivation domain (TAD) domain 2 found in p53 proteins. In p53 two TAD domains are found termed TAD1 (residues 1-39) and TAD2 (residues 40-61), both of which have been shown to be able to independently activate gene transcription and are intrinsically disordered protein domains that adopt a helical conformation for at least part of their length when bound. This inherent flexibility allows the TADs to adapt to and bind a broad range of proteins. This entry describes TAD2 which can independently interact with Taz2 domain of the histone acetyltransferase p300. It has also been shown to bind to OB-fold domain of replication protein 70 A (RPA) as well as the pleckstrin homology (PH) domain of the p62 and Tfb1 subunits of human and yeast TFIIH.


:

Pssm-ID: 375947  Cd Length: 25  Bit Score: 60.15  E-value: 3.03e-13
                          10        20
                  ....*....|....*....|....*
5HPD_A        132 LPSQAMDDLMLSPDDIEQWFTEDPG 156
Cdd:pfam18521   1 LPSQAMDDLMLSPDDIEQWFTEDPG 25
P53_TAD pfam08563
P53 transactivation motif; The binding of the p53 transactivation domain by regulatory ...
 103-127 8.22e-09

P53 transactivation motif; The binding of the p53 transactivation domain by regulatory proteins regulates p53 transcription activation. This motif is comprised of a single amphipathic alpha helix and contains a highly conserved sequence.


:

Pssm-ID: 462520  Cd Length: 25  Bit Score: 48.32  E-value: 8.22e-09
                          10        20
                  ....*....|....*....|....*
5HPD_A        103 SDPSVEPPLSQETFSDLWKLLPENN 127
Cdd:pfam08563   1 SDLGLELPLSQETFSDLWNLLPPST 25
 
Name Accession Description Interval E-value
zf-TAZ pfam02135
TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 ...
 10-78 1.48e-18

TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1. The zinc coordinating motif that is necessary for binding to target DNA sequences consists of HCCC.


Pssm-ID: 460457  Cd Length: 72  Bit Score: 74.73  E-value: 1.48e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
5HPD_A         10 IQRCIQSLVHACQCRNAN---CSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCyHAKHCQENKCPV 78
Cdd:pfam02135   1 LQRWLLLLLHASKCSAPGpgpCSLPNCRKMKRLLRHMATCKRGGGCPYPHCKRSRQLLR-HAKNCKDEDCPV 71
ZnF_TAZ smart00551
TAZ zinc finger, present in p300 and CBP;
4-82 1.85e-18

TAZ zinc finger, present in p300 and CBP;


Pssm-ID: 214717  Cd Length: 79  Bit Score: 74.71  E-value: 1.85e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5HPD_A           4 ESRRLSIQRCIQSLVHACQC--RNANCSLPSCQKMKRVVQHTKGCK--RKTNGGCPVCKQLIalccYHAKHCQENKCPVP 79
Cdd:smart00551   1 QTRYKQLQRWLELLVHARRCkaREAKCQYPNCKTMKKLLRHMDSCKvrKCKYGYCASCKQLW----QHSKHCKDSNCPVC 76


                   ...
5HPD_A          80 FCL 82
Cdd:smart00551  77 KCV 79
TAD2 pfam18521
Transactivation domain 2; This is a N-terminal transactivation domain (TAD) domain 2 found in ...
 132-156 3.03e-13

Transactivation domain 2; This is a N-terminal transactivation domain (TAD) domain 2 found in p53 proteins. In p53 two TAD domains are found termed TAD1 (residues 1-39) and TAD2 (residues 40-61), both of which have been shown to be able to independently activate gene transcription and are intrinsically disordered protein domains that adopt a helical conformation for at least part of their length when bound. This inherent flexibility allows the TADs to adapt to and bind a broad range of proteins. This entry describes TAD2 which can independently interact with Taz2 domain of the histone acetyltransferase p300. It has also been shown to bind to OB-fold domain of replication protein 70 A (RPA) as well as the pleckstrin homology (PH) domain of the p62 and Tfb1 subunits of human and yeast TFIIH.


Pssm-ID: 375947  Cd Length: 25  Bit Score: 60.15  E-value: 3.03e-13
                          10        20
                  ....*....|....*....|....*
5HPD_A        132 LPSQAMDDLMLSPDDIEQWFTEDPG 156
Cdd:pfam18521   1 LPSQAMDDLMLSPDDIEQWFTEDPG 25
P53_TAD pfam08563
P53 transactivation motif; The binding of the p53 transactivation domain by regulatory ...
 103-127 8.22e-09

P53 transactivation motif; The binding of the p53 transactivation domain by regulatory proteins regulates p53 transcription activation. This motif is comprised of a single amphipathic alpha helix and contains a highly conserved sequence.


Pssm-ID: 462520  Cd Length: 25  Bit Score: 48.32  E-value: 8.22e-09
                          10        20
                  ....*....|....*....|....*
5HPD_A        103 SDPSVEPPLSQETFSDLWKLLPENN 127
Cdd:pfam08563   1 SDLGLELPLSQETFSDLWNLLPPST 25
 
Name Accession Description Interval E-value
zf-TAZ pfam02135
TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 ...
 10-78 1.48e-18

TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1. The zinc coordinating motif that is necessary for binding to target DNA sequences consists of HCCC.


Pssm-ID: 460457  Cd Length: 72  Bit Score: 74.73  E-value: 1.48e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
5HPD_A         10 IQRCIQSLVHACQCRNAN---CSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCyHAKHCQENKCPV 78
Cdd:pfam02135   1 LQRWLLLLLHASKCSAPGpgpCSLPNCRKMKRLLRHMATCKRGGGCPYPHCKRSRQLLR-HAKNCKDEDCPV 71
ZnF_TAZ smart00551
TAZ zinc finger, present in p300 and CBP;
4-82 1.85e-18

TAZ zinc finger, present in p300 and CBP;


Pssm-ID: 214717  Cd Length: 79  Bit Score: 74.71  E-value: 1.85e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5HPD_A           4 ESRRLSIQRCIQSLVHACQC--RNANCSLPSCQKMKRVVQHTKGCK--RKTNGGCPVCKQLIalccYHAKHCQENKCPVP 79
Cdd:smart00551   1 QTRYKQLQRWLELLVHARRCkaREAKCQYPNCKTMKKLLRHMDSCKvrKCKYGYCASCKQLW----QHSKHCKDSNCPVC 76


                   ...
5HPD_A          80 FCL 82
Cdd:smart00551  77 KCV 79
TAD2 pfam18521
Transactivation domain 2; This is a N-terminal transactivation domain (TAD) domain 2 found in ...
 132-156 3.03e-13

Transactivation domain 2; This is a N-terminal transactivation domain (TAD) domain 2 found in p53 proteins. In p53 two TAD domains are found termed TAD1 (residues 1-39) and TAD2 (residues 40-61), both of which have been shown to be able to independently activate gene transcription and are intrinsically disordered protein domains that adopt a helical conformation for at least part of their length when bound. This inherent flexibility allows the TADs to adapt to and bind a broad range of proteins. This entry describes TAD2 which can independently interact with Taz2 domain of the histone acetyltransferase p300. It has also been shown to bind to OB-fold domain of replication protein 70 A (RPA) as well as the pleckstrin homology (PH) domain of the p62 and Tfb1 subunits of human and yeast TFIIH.


Pssm-ID: 375947  Cd Length: 25  Bit Score: 60.15  E-value: 3.03e-13
                          10        20
                  ....*....|....*....|....*
5HPD_A        132 LPSQAMDDLMLSPDDIEQWFTEDPG 156
Cdd:pfam18521   1 LPSQAMDDLMLSPDDIEQWFTEDPG 25
P53_TAD pfam08563
P53 transactivation motif; The binding of the p53 transactivation domain by regulatory ...
 103-127 8.22e-09

P53 transactivation motif; The binding of the p53 transactivation domain by regulatory proteins regulates p53 transcription activation. This motif is comprised of a single amphipathic alpha helix and contains a highly conserved sequence.


Pssm-ID: 462520  Cd Length: 25  Bit Score: 48.32  E-value: 8.22e-09
                          10        20
                  ....*....|....*....|....*
5HPD_A        103 SDPSVEPPLSQETFSDLWKLLPENN 127
Cdd:pfam08563   1 SDLGLELPLSQETFSDLWNLLPPST 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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