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Conserved domains on  [gi|1384036354|pdb|5WC2|A]
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Chain A, Pachytene checkpoint protein 2 homolog

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
121-319 3.76e-133

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


:

Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 381.02  E-value: 3.76e-133
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      121 AANHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTLLFSDKNVNSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRL 200
Cdd:cd19508   1 AANHWLLPAAEFHGLWESLIYDSNLKSRLLDYVTTTLLFSDKNVNTNLITWNRLVLLHGPPGTGKTSLCKALAQKLSIRL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      201 SSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLIDDKDALVFVLIDAVESLTAARNACRAGTEPSDAIRVVNAV 280
Cdd:cd19508  81 SSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQELIDDKDALVFVLIDEVESLAAARSASSSGTEPSDAIRVVNAV 160
                       170       180       190
                ....*....|....*....|....*....|....*....
5WC2_A      281 LTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYI 319
Cdd:cd19508 161 LTQIDRIKRYHNNVILLTSNLLEKIDVAFVDRADIKQYI 199
McrB super family cl34253
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
34-205 1.23e-05

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


The actual alignment was detected with superfamily member COG1401:

Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 47.46  E-value: 1.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A       34 KKEDINLSVRKLLNRHNIVFGDYTWTEFDEPFLTRNVQSVSIIDTELKVKDSQ--PIDLSACTVALHIFQLNEDGPSSEN 111
Cdd:COG1401  79 LLLDLEKVELNEKLALSEAAVAIEELYELEADSEIEAVGLLLELAERSDALEAleRARLLLELADLEERAALETEVLEAL 158
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      112 LEEETENIIAANHWVLPAAEFHGLWDSLVYDVEVKShLLDYVMTTLLFSDKNVNSNLITWNRV---VLLHGPPGTGKTSL 188
Cdd:COG1401 159 EAELEELLAAPEDLSADALAAELSAAEELYSEDLES-EDDYLKDLLREKFEETLEAFLAALKTkknVILAGPPGTGKTYL 237
                       170
                ....*....|....*..
5WC2_A      189 CKALAQKLTIRLSSRYR 205
Cdd:COG1401 238 ARRLAEALGGEDNGRIE 254
 
Name Accession Description Interval E-value
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
121-319 3.76e-133

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 381.02  E-value: 3.76e-133
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      121 AANHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTLLFSDKNVNSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRL 200
Cdd:cd19508   1 AANHWLLPAAEFHGLWESLIYDSNLKSRLLDYVTTTLLFSDKNVNTNLITWNRLVLLHGPPGTGKTSLCKALAQKLSIRL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      201 SSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLIDDKDALVFVLIDAVESLTAARNACRAGTEPSDAIRVVNAV 280
Cdd:cd19508  81 SSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQELIDDKDALVFVLIDEVESLAAARSASSSGTEPSDAIRVVNAV 160
                       170       180       190
                ....*....|....*....|....*....|....*....
5WC2_A      281 LTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYI 319
Cdd:cd19508 161 LTQIDRIKRYHNNVILLTSNLLEKIDVAFVDRADIKQYI 199
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
175-320 5.59e-29

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 109.99  E-value: 5.59e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A        175 VLLHGPPGTGKTSLCKALAQKLTIRlssryrygqLIEINSHSLFSKWFSESGKLVTKMFQKIQdliddKDALVFVLIDAV 254
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAP---------FIEISGSELVSKYVGESEKRLRELFEAAK-----KLAPCVIFIDEI 66
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
5WC2_A        255 ESLTAARNacraGTEPSDAIRVVNAVLTQIDQIK-RHSNVVILTTSNITEKIDVAFVDRADIKQYIG 320
Cdd:pfam00004  67 DALAGSRG----SGGDSESRRVVNQLLTELDGFTsSNSKVIVIAATNRPDKLDPALLGRFDRIIEFP 129
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
135-414 5.20e-26

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 108.84  E-value: 5.20e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      135 LWDSLVYDVEVKSHLLDYVMTTLLFSDKNVNSNLiTWNRVVLLHGPPGTGKTSLCKALAQKLTirlssryryGQLIEINS 214
Cdd:COG0464 155 ILDDLGGLEEVKEELRELVALPLKRPELREEYGL-PPPRGLLLYGPPGTGKTLLARALAGELG---------LPLIEVDL 224
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      215 HSLFSKWFSESGKLVTKMFQKIQDLiddkdALVFVLIDAVESLTAARNACRAGTepsdAIRVVNAVLTQIDQIKRHSnVV 294
Cdd:COG0464 225 SDLVSKYVGETEKNLREVFDKARGL-----APCVLFIDEADALAGKRGEVGDGV----GRRVVNTLLTEMEELRSDV-VV 294
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      295 ILTTSNItEKIDVAFVDRADIKQYIGPPSAA---AIFKIYLscleelmkcqiiyPRQQLltlrelemigfiennvsKLSL 371
Cdd:COG0464 295 IAATNRP-DLLDPALLRRFDEIIFFPLPDAEerlEIFRIHL-------------RKRPL-----------------DEDV 343
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
5WC2_A      372 LLNDISRKSEGLSGR----VLRKLpfLAHALYVQAPTVTIEGFLQAL 414
Cdd:COG0464 344 DLEELAEATEGLSGAdirnVVRRA--ALQALRLGREPVTTEDLLEAL 388
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
169-331 6.68e-17

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 83.03  E-value: 6.68e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A        169 ITWNRVVLLHGPPGTGKTSLCKALAQKltirlssryRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQdliddKDALVF 248
Cdd:TIGR01243 484 IRPPKGVLLFGPPGTGKTLLAKAVATE---------SGANFIAVRGPEILSKWVGESEKAIREIFRKAR-----QAAPAI 549
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A        249 VLIDAVESLTAARNAcRAGTEPSDaiRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFV--DRADIKQYIGPPSAAA 326
Cdd:TIGR01243 550 IFFDEIDAIAPARGA-RFDTSVTD--RIVNQLLTEMDGIQELSNVVVIAATNRPDILDPALLrpGRFDRLILVPPPDEEA 626

                  ....*...
5WC2_A        327 ---IFKIY 331
Cdd:TIGR01243 627 rkeIFKIH 634
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
172-322 3.75e-10

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 58.15  E-value: 3.75e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A         172 NRVVLLHGPPGTGKTSLCKALAQKL--------TIRLSSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLIDDk 243
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELgppgggviYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPD- 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
5WC2_A         244 dalvFVLIDAVESLTAARNacragtepSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYIGPP 322
Cdd:smart00382  81 ----VLILDEITSLLDAEQ--------EALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRRIVLLLI 147
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
175-333 1.11e-07

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 53.62  E-value: 1.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A       175 VLLHGPPGTGKTSLCKALAQKLTirlssryryGQLIEINSHSLFSKWFSESGKLVTKMFQkiqdlIDDKDALVFVLIDAV 254
Cdd:PTZ00361 220 VILYGPPGTGKTLLAKAVANETS---------ATFLRVVGSELIQKYLGDGPKLVRELFR-----VAEENAPSIVFIDEI 285
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A       255 ESLTAARNACRAGTEpSDAIRVVNAVLTQIDQIKRHSNV-VILTTSNItEKIDVAFVDRADIKQYIGPP-----SAAAIF 328
Cdd:PTZ00361 286 DAIGTKRYDATSGGE-KEIQRTMLELLNQLDGFDSRGDVkVIMATNRI-ESLDPALIRPGRIDRKIEFPnpdekTKRRIF 363

                 ....*
5WC2_A       329 KIYLS 333
Cdd:PTZ00361 364 EIHTS 368
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
34-205 1.23e-05

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 47.46  E-value: 1.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A       34 KKEDINLSVRKLLNRHNIVFGDYTWTEFDEPFLTRNVQSVSIIDTELKVKDSQ--PIDLSACTVALHIFQLNEDGPSSEN 111
Cdd:COG1401  79 LLLDLEKVELNEKLALSEAAVAIEELYELEADSEIEAVGLLLELAERSDALEAleRARLLLELADLEERAALETEVLEAL 158
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      112 LEEETENIIAANHWVLPAAEFHGLWDSLVYDVEVKShLLDYVMTTLLFSDKNVNSNLITWNRV---VLLHGPPGTGKTSL 188
Cdd:COG1401 159 EAELEELLAAPEDLSADALAAELSAAEELYSEDLES-EDDYLKDLLREKFEETLEAFLAALKTkknVILAGPPGTGKTYL 237
                       170
                ....*....|....*..
5WC2_A      189 CKALAQKLTIRLSSRYR 205
Cdd:COG1401 238 ARRLAEALGGEDNGRIE 254
 
Name Accession Description Interval E-value
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
121-319 3.76e-133

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 381.02  E-value: 3.76e-133
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      121 AANHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTLLFSDKNVNSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRL 200
Cdd:cd19508   1 AANHWLLPAAEFHGLWESLIYDSNLKSRLLDYVTTTLLFSDKNVNTNLITWNRLVLLHGPPGTGKTSLCKALAQKLSIRL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      201 SSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLIDDKDALVFVLIDAVESLTAARNACRAGTEPSDAIRVVNAV 280
Cdd:cd19508  81 SSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQELIDDKDALVFVLIDEVESLAAARSASSSGTEPSDAIRVVNAV 160
                       170       180       190
                ....*....|....*....|....*....|....*....
5WC2_A      281 LTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYI 319
Cdd:cd19508 161 LTQIDRIKRYHNNVILLTSNLLEKIDVAFVDRADIKQYI 199
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
175-320 5.59e-29

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 109.99  E-value: 5.59e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A        175 VLLHGPPGTGKTSLCKALAQKLTIRlssryrygqLIEINSHSLFSKWFSESGKLVTKMFQKIQdliddKDALVFVLIDAV 254
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAP---------FIEISGSELVSKYVGESEKRLRELFEAAK-----KLAPCVIFIDEI 66
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
5WC2_A        255 ESLTAARNacraGTEPSDAIRVVNAVLTQIDQIK-RHSNVVILTTSNITEKIDVAFVDRADIKQYIG 320
Cdd:pfam00004  67 DALAGSRG----SGGDSESRRVVNQLLTELDGFTsSNSKVIVIAATNRPDKLDPALLGRFDRIIEFP 129
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
135-414 5.20e-26

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 108.84  E-value: 5.20e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      135 LWDSLVYDVEVKSHLLDYVMTTLLFSDKNVNSNLiTWNRVVLLHGPPGTGKTSLCKALAQKLTirlssryryGQLIEINS 214
Cdd:COG0464 155 ILDDLGGLEEVKEELRELVALPLKRPELREEYGL-PPPRGLLLYGPPGTGKTLLARALAGELG---------LPLIEVDL 224
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      215 HSLFSKWFSESGKLVTKMFQKIQDLiddkdALVFVLIDAVESLTAARNACRAGTepsdAIRVVNAVLTQIDQIKRHSnVV 294
Cdd:COG0464 225 SDLVSKYVGETEKNLREVFDKARGL-----APCVLFIDEADALAGKRGEVGDGV----GRRVVNTLLTEMEELRSDV-VV 294
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      295 ILTTSNItEKIDVAFVDRADIKQYIGPPSAA---AIFKIYLscleelmkcqiiyPRQQLltlrelemigfiennvsKLSL 371
Cdd:COG0464 295 IAATNRP-DLLDPALLRRFDEIIFFPLPDAEerlEIFRIHL-------------RKRPL-----------------DEDV 343
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
5WC2_A      372 LLNDISRKSEGLSGR----VLRKLpfLAHALYVQAPTVTIEGFLQAL 414
Cdd:COG0464 344 DLEELAEATEGLSGAdirnVVRRA--ALQALRLGREPVTTEDLLEAL 388
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
175-319 5.87e-25

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 100.05  E-value: 5.87e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      175 VLLHGPPGTGKTSLCKALAQKLTIrlssryrygQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLiddkdALVFVLIDAV 254
Cdd:cd19481  29 ILLYGPPGTGKTLLAKALAGELGL---------PLIVVKLSSLLSKYVGESEKNLRKIFERARRL-----APCILFIDEI 94
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
5WC2_A      255 ESLTAARnacRAGTEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVD--RADIKQYI 319
Cdd:cd19481  95 DAIGRKR---DSSGESGELRRVLNQLLTELDGVNSRSKVLVIAATNRPDLLDPALLRpgRFDEVIEF 158
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
175-415 2.61e-22

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 97.00  E-value: 2.61e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      175 VLLHGPPGTGKTSLCKALAQKLTIrlssryrygQLIEINSHSLFSKWFSESGKLVTKMFQKIQdliddKDALVFVLIDAV 254
Cdd:COG1222 115 VLLYGPPGTGKTLLAKAVAGELGA---------PFIRVRGSELVSKYIGEGARNVREVFELAR-----EKAPSIIFIDEI 180
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      255 ESLTAARNAcrAGTepSDAI-RVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFV--DRADIKQYIGPPSAAA---IF 328
Cdd:COG1222 181 DAIAARRTD--DGT--SGEVqRTVNQLLAELDGFESRGDVLIIAATNRPDLLDPALLrpGRFDRVIEVPLPDEEAreeIL 256
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      329 KIYLScleelmkcqiiyprqqlltlrelemigfiENNVSKlSLLLNDISRKSEGLSGRVLRKLPFLA--HALYVQAPTVT 406
Cdd:COG1222 257 KIHLR-----------------------------DMPLAD-DVDLDKLAKLTEGFSGADLKAIVTEAgmFAIREGRDTVT 306

                ....*....
5WC2_A      407 IEGFLQALS 415
Cdd:COG1222 307 MEDLEKAIE 315
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
173-427 3.25e-20

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 89.17  E-value: 3.25e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      173 RVVLLHGPPGTGKTSLCKALAQKLTIRlssryrygqLIEINSHSLFSKWFSESGKLVTKMFqkiqDLIDDKDALVFvlID 252
Cdd:COG1223  36 RKILFYGPPGTGKTMLAEALAGELKLP---------LLTVRLDSLIGSYLGETARNLRKLF----DFARRAPCVIF--FD 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      253 AVESLTAARnacRAGTEPSDAIRVVNAVLTQIDQIKrhSNVVILTTSNITEKIDVAFVDRADIKQYIGPPSAAAIFKIYL 332
Cdd:COG1223 101 EFDAIAKDR---GDQNDVGEVKRVVNALLQELDGLP--SGSVVIAATNHPELLDSALWRRFDEVIEFPLPDKEERKEILE 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      333 SCLEELmkcqiiyprqqlltlrelemigfiennVSKLSLLLNDISRKSEGLSGRVLRKL--PFLAHALYVQAPTVTIEGF 410
Cdd:COG1223 176 LNLKKF---------------------------PLPFELDLKKLAKKLEGLSGADIEKVlkTALKKAILEDREKVTKEDL 228
                       250
                ....*....|....*..
5WC2_A      411 LQALSLAVDKQFEERKK 427
Cdd:COG1223 229 EEALKQRKERKKEPKKE 245
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
169-308 1.48e-19

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 85.42  E-value: 1.48e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      169 ITWNRVVLLHGPPGTGKTSLCKALAQKLTIrlssryrygQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLiddKDALVF 248
Cdd:cd19503  31 LKPPRGVLLHGPPGTGKTLLARAVANEAGA---------NFLSISGPSIVSKYLGESEKNLREIFEEARSH---APSIIF 98
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      249 vlIDAVESLTAARNACRAGTEpsdaIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVA 308
Cdd:cd19503  99 --IDEIDALAPKREEDQREVE----RRVVAQLLTLMDGMSSRGKVVVIAATNRPDAIDPA 152
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
144-319 6.59e-18

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 80.47  E-value: 6.59e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      144 EVKSHLLDYVMTTLLFSDknVNSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTirlssryryGQLIEINSHSLFSKWFS 223
Cdd:cd19509   6 DAKEALKEAVILPSLRPD--LFPGLRGPPRGILLYGPPGTGKTLLARAVASESG---------STFFSISASSLVSKWVG 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      224 ESGKLVTKMFQKIQDLiddKDALVFvlIDAVESLTAARNAcragTEPSDAIRVVNAVLTQIDQIKRHSN--VVILTTSNI 301
Cdd:cd19509  75 ESEKIVRALFALAREL---QPSIIF--IDEIDSLLSERGS----GEHEASRRVKTEFLVQMDGVLNKPEdrVLVLGATNR 145
                       170
                ....*....|....*...
5WC2_A      302 TEKIDVAFVDRADIKQYI 319
Cdd:cd19509 146 PWELDEAFLRRFEKRIYI 163
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
175-308 1.22e-17

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 79.63  E-value: 1.22e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      175 VLLHGPPGTGKTSLCKALAQKLTIrlssryrygQLIEINSHSLFSKWFSESGKLVTKMFQKIQdliDDKDALVFvlIDAV 254
Cdd:cd19511  30 VLLYGPPGCGKTLLAKALASEAGL---------NFISVKGPELFSKYVGESERAVREIFQKAR---QAAPCIIF--FDEI 95
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
5WC2_A      255 ESLTAARNAcRAGTEPSDaiRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVA 308
Cdd:cd19511  96 DSLAPRRGQ-SDSSGVTD--RVVSQLLTELDGIESLKGVVVIAATNRPDMIDPA 146
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
145-319 3.07e-17

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 78.71  E-value: 3.07e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      145 VKSHLLDYVMTTLLFSDKNVNSNLiTWNRVVLLHGPPGTGKTSLCKALAQKLTirlssryryGQLIEINSHSLFSKWFSE 224
Cdd:cd19528   1 VKRELQELVQYPVEHPDKFLKFGM-TPSKGVLFYGPPGCGKTLLAKAIANECQ---------ANFISVKGPELLTMWFGE 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      225 SGKLVTKMFQKIQdliddKDALVFVLIDAVESLTAARNAcRAGTEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEK 304
Cdd:cd19528  71 SEANVRDIFDKAR-----AAAPCVLFFDELDSIAKARGG-NIGDAGGAADRVINQILTEMDGMNTKKNVFIIGATNRPDI 144
                       170
                ....*....|....*
5WC2_A      305 IDVAFVDRADIKQYI 319
Cdd:cd19528 145 IDPAILRPGRLDQLI 159
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
169-331 6.68e-17

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 83.03  E-value: 6.68e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A        169 ITWNRVVLLHGPPGTGKTSLCKALAQKltirlssryRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQdliddKDALVF 248
Cdd:TIGR01243 484 IRPPKGVLLFGPPGTGKTLLAKAVATE---------SGANFIAVRGPEILSKWVGESEKAIREIFRKAR-----QAAPAI 549
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A        249 VLIDAVESLTAARNAcRAGTEPSDaiRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFV--DRADIKQYIGPPSAAA 326
Cdd:TIGR01243 550 IFFDEIDAIAPARGA-RFDTSVTD--RIVNQLLTEMDGIQELSNVVVIAATNRPDILDPALLrpGRFDRLILVPPPDEEA 626

                  ....*...
5WC2_A        327 ---IFKIY 331
Cdd:TIGR01243 627 rkeIFKIH 634
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
145-310 2.20e-15

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 73.30  E-value: 2.20e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      145 VKSHLLDYVMTTLLFSDKNVNSNlITWNRVVLLHGPPGTGKTSLCKALAQKltirlsSRYRYgqlIEINSHSLFSKWFSE 224
Cdd:cd19529   1 VKQELKEAVEWPLLKPEVFKRLG-IRPPKGILLYGPPGTGKTLLAKAVATE------SNANF---ISVKGPELLSKWVGE 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      225 SGKLVTKMFQKIQDLiddkdALVFVLIDAVESLtaarnACRAGTEPSDAI--RVVNAVLTQIDQIKRHSNVVILTTSNIT 302
Cdd:cd19529  71 SEKAIREIFRKARQV-----APCVIFFDEIDSI-----APRRGTTGDSGVteRVVNQLLTELDGLEEMNGVVVIAATNRP 140

                ....*...
5WC2_A      303 EKIDVAFV 310
Cdd:cd19529 141 DIIDPALL 148
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
144-312 1.02e-14

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 71.69  E-value: 1.02e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      144 EVKSHLLDYVMTTLLFSDKNVNSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRlssryrygqLIEINSHSLFSKWFS 223
Cdd:cd19520   7 EVITELKELVILPLQRPELFDNSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGAR---------FINLQVSSLTDKWYG 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      224 ESGKLVTKMF---QKIQDLIddkdalvfVLIDAVESLTAARNacragtePSD--AIRVVNA-VLTQIDQI--KRHSNVVI 295
Cdd:cd19520  78 ESQKLVAAVFslaSKLQPSI--------IFIDEIDSFLRQRS-------STDheATAMMKAeFMSLWDGLstDGNCRVIV 142
                       170
                ....*....|....*..
5WC2_A      296 LTTSNITEKIDVAFVDR 312
Cdd:cd19520 143 MGATNRPQDLDEAILRR 159
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
168-319 7.76e-14

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 69.12  E-value: 7.76e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      168 LITWNRV----VLLHGPPGTGKTSLCKALAQKLTIRLSSryrygqlieINSHSLFSKWFSESGKLVTKMFQKIQdliDDK 243
Cdd:cd19521  32 LFTGNRKpwsgILLYGPPGTGKSYLAKAVATEANSTFFS---------VSSSDLVSKWMGESEKLVKQLFAMAR---ENK 99
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
5WC2_A      244 DALVFvlIDAVESLTAARNAcragTEPSDAIRVVNAVLTQIDQIKRHSN-VVILTTSNITEKIDVAFVDRADIKQYI 319
Cdd:cd19521 100 PSIIF--IDEVDSLCGTRGE----GESEASRRIKTELLVQMNGVGNDSQgVLVLGATNIPWQLDSAIRRRFEKRIYI 170
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
173-308 4.52e-13

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 66.69  E-value: 4.52e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      173 RVVLLHGPPGTGKTSLCKALAQKltirlSSRYrygqLIEINSHSLFSKWFSESGKLVTKMFQKIQdliddKDALVFVLID 252
Cdd:cd19519  35 RGILLYGPPGTGKTLIARAVANE-----TGAF----FFLINGPEIMSKLAGESESNLRKAFEEAE-----KNAPAIIFID 100
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
5WC2_A      253 AVESLTAARNACRAGTEPsdaiRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVA 308
Cdd:cd19519 101 EIDAIAPKREKTHGEVER----RIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPA 152
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
175-309 1.98e-11

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 62.12  E-value: 1.98e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      175 VLLHGPPGTGKTSLCKALAQKLTIrlssryrygQLIEINSHSLFSKWFSESGKLVTKMFQKIQDliddkDALVFVLIDAV 254
Cdd:cd19530  33 VLLYGPPGCGKTLLAKAVANESGA---------NFISVKGPELLNKYVGESERAVRQVFQRARA-----SAPCVIFFDEV 98
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
5WC2_A      255 ESLTAARNacraGTEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAF 309
Cdd:cd19530  99 DALVPKRG----DGGSWASERVVNQLLTEMDGLEERSNVFVIAATNRPDIIDPAM 149
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
175-322 5.24e-11

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 64.54  E-value: 5.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A        175 VLLHGPPGTGKTSLCKALAQKLTirlssryryGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDliddkDALVFVLIDAV 254
Cdd:TIGR01243 215 VLLYGPPGTGKTLLAKAVANEAG---------AYFISINGPEIMSKYYGESEERLREIFKEAEE-----NAPSIIFIDEI 280
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A        255 ESLTAARNACRAGTEPsdaiRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAF--VDRADIKQYIGPP 322
Cdd:TIGR01243 281 DAIAPKREEVTGEVEK----RVVAQLLTLMDGLKGRGRVIVIGATNRPDALDPALrrPGRFDREIVIRVP 346
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
175-321 1.02e-10

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 59.85  E-value: 1.02e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      175 VLLHGPPGTGKTSLCKALAQKLtirlssRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLidDKDALVFVLIDAV 254
Cdd:cd00009  22 LLLYGPPGTGKTTLARAIANEL------FRPGAPFLYLNASDLLEGLVVAELFGHFLVRLLFELA--EKAKPGVLFIDEI 93
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
5WC2_A      255 ESLTAARNAcragtepsdaiRVVNAVLTQIDQIKRHSNV-VILTTSNITE-KIDVAFVDRADIKQYIGP 321
Cdd:cd00009  94 DSLSRGAQN-----------ALLRVLETLNDLRIDRENVrVIGATNRPLLgDLDRALYDRLDIRIVIPL 151
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
175-319 1.45e-10

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 59.61  E-value: 1.45e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      175 VLLHGPPGTGKTSLCKALAQKLTIrlssryrygQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLiddkdALVFVLIDAV 254
Cdd:cd19522  36 VLMVGPPGTGKTLLAKAVATECGT---------TFFNVSSSTLTSKYRGESEKLVRLLFEMARFY-----APTTIFIDEI 101
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
5WC2_A      255 ESLTAARNacrAGTEPSDAIRVVNAVLTQIDQIKRHSN-------VVILTTSNITEKIDVAFVDRADIKQYI 319
Cdd:cd19522 102 DSICSRRG---TSEEHEASRRVKSELLVQMDGVGGASEnddpskmVMVLAATNFPWDIDEALRRRLEKRIYI 170
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
172-322 3.75e-10

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 58.15  E-value: 3.75e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A         172 NRVVLLHGPPGTGKTSLCKALAQKL--------TIRLSSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLIDDk 243
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELgppgggviYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPD- 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
5WC2_A         244 dalvFVLIDAVESLTAARNacragtepSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYIGPP 322
Cdd:smart00382  81 ----VLILDEITSLLDAEQ--------EALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRRIVLLLI 147
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
175-308 1.04e-09

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 57.35  E-value: 1.04e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      175 VLLHGPPGTGKTSLCKALAQKLTirlssryryGQLIEINSHSLFSKWFSESGKLVTKMFQkiqdLIDDKDALVfVLIDAV 254
Cdd:cd19502  40 VLLYGPPGTGKTLLAKAVANHTD---------ATFIRVVGSELVQKYIGEGARLVRELFE----MAREKAPSI-IFIDEI 105
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
5WC2_A      255 ESLTAARNACRAGTEpSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVA 308
Cdd:cd19502 106 DAIGAKRFDSGTGGD-REVQRTMLELLNQLDGFDPRGNIKVIMATNRPDILDPA 158
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
175-310 2.94e-09

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 55.96  E-value: 2.94e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      175 VLLHGPPGTGKTSLCKALAQKLTIRLSSRyrygqlieINSHSLFSKWFSESGKLVTKMF---QKIQDLIDDKDALVFVLI 251
Cdd:cd19504  38 ILLYGPPGTGKTLMARQIGKMLNAREPKI--------VNGPEILNKYVGESEANIRKLFadaEEEQRRLGANSGLHIIIF 109
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
5WC2_A      252 DAVESLTAARNACRAGTEPSDAirVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFV 310
Cdd:cd19504 110 DEIDAICKQRGSMAGSTGVHDT--VVNQLLSKIDGVEQLNNILVIGMTNRKDLIDEALL 166
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
175-319 1.42e-08

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 54.22  E-value: 1.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      175 VLLHGPPGTGKTSLCKALAQKLTirlssryryGQLIEINSHSLFSKWFSESGKLVTKMFQ--KIQdliddKDALVFvlID 252
Cdd:cd19525  58 ILLFGPPGTGKTLIGKCIASQSG---------ATFFSISASSLTSKWVGEGEKMVRALFSvaRCK-----QPAVIF--ID 121
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
5WC2_A      253 AVESLTAArnacRAGTEPSDAIRVVNAVLTQIDQIKRHSN--VVILTTSNITEKIDVAFVDRADIKQYI 319
Cdd:cd19525 122 EIDSLLSQ----RGEGEHESSRRIKTEFLVQLDGATTSSEdrILVVGATNRPQEIDEAARRRLVKRLYI 186
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
175-308 5.27e-08

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 52.05  E-value: 5.27e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      175 VLLHGPPGTGKTSLCKALAQKLTIRlssryrygqLIEINSHSLFSKWFSESGKLVTKMFQKIQDLiddKDALVFvlIDAV 254
Cdd:cd19526  30 ILLYGPPGCGKTLLASAIASECGLN---------FISVKGPELLNKYIGASEQNVRDLFSRAQSA---KPCILF--FDEF 95
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
5WC2_A      255 ESLTAARNACRAGTepSDaiRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVA 308
Cdd:cd19526  96 DSIAPKRGHDSTGV--TD--RVVNQLLTQLDGVEGLDGVYVLAATSRPDLIDPA 145
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
145-310 7.70e-08

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 51.74  E-value: 7.70e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      145 VKSHLLDYVMTTLLFSDknVNSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSryrygqlieINSHSLFSKWFSE 224
Cdd:cd19527   1 VKKEILDTIQLPLEHPE--LFSSGLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLS---------VKGPELINMYIGE 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      225 SGKLVTKMFQKIQDLiddKDALVFvlIDAVESLTAARNacRAGTEPSDAIRVVNAVLTQIDQI-KRHSNVVILTTSNITE 303
Cdd:cd19527  70 SEANVREVFQKARDA---KPCVIF--FDELDSLAPSRG--NSGDSGGVMDRVVSQLLAELDGMsSSGQDVFVIGATNRPD 142

                ....*..
5WC2_A      304 KIDVAFV 310
Cdd:cd19527 143 LLDPALL 149
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
173-319 8.81e-08

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 51.39  E-value: 8.81e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      173 RVVLLHGPPGTGKTSLCKALAQKLTIrlssryrygQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLiddKDALVFvlID 252
Cdd:cd19524  34 RGLLLFGPPGNGKTMLAKAVAAESNA---------TFFNISAASLTSKYVGEGEKLVRALFAVAREL---QPSIIF--ID 99
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
5WC2_A      253 AVESLTAARNAcragTEPSDAIRVVNAVLTQIDQIKRHSN--VVILTTSNITEKIDVAFVDRADIKQYI 319
Cdd:cd19524 100 EVDSLLSERSE----GEHEASRRLKTEFLIEFDGVQSNGDdrVLVMGATNRPQELDDAVLRRFTKRVYV 164
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
175-333 1.11e-07

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 53.62  E-value: 1.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A       175 VLLHGPPGTGKTSLCKALAQKLTirlssryryGQLIEINSHSLFSKWFSESGKLVTKMFQkiqdlIDDKDALVFVLIDAV 254
Cdd:PTZ00361 220 VILYGPPGTGKTLLAKAVANETS---------ATFLRVVGSELIQKYLGDGPKLVRELFR-----VAEENAPSIVFIDEI 285
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A       255 ESLTAARNACRAGTEpSDAIRVVNAVLTQIDQIKRHSNV-VILTTSNItEKIDVAFVDRADIKQYIGPP-----SAAAIF 328
Cdd:PTZ00361 286 DAIGTKRYDATSGGE-KEIQRTMLELLNQLDGFDSRGDVkVIMATNRI-ESLDPALIRPGRIDRKIEFPnpdekTKRRIF 363

                 ....*
5WC2_A       329 KIYLS 333
Cdd:PTZ00361 364 EIHTS 368
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
173-308 1.21e-07

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 51.25  E-value: 1.21e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      173 RVVLLHGPPGTGKTSLCKALAQKLTIrlssryrygQLIEINSHSLFSKWFSESGKlvtkmfqKIQDLIDD--KDALVFVL 250
Cdd:cd19518  35 RGVLLHGPPGCGKTMLANAIAGELKV---------PFLKISATEIVSGVSGESEE-------KIRELFDQaiSNAPCIVF 98
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
5WC2_A      251 IDAVESLTAARNACRAGTEPsdaiRVVNAVLTQIDQIKRHSN----VVILTTSNITEKIDVA 308
Cdd:cd19518  99 IDEIDAITPKRESAQREMER----RIVSQLLTCMDELNNEKTaggpVLVIGATNRPDSLDPA 156
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
175-308 6.30e-07

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 49.15  E-value: 6.30e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      175 VLLHGPPGTGKTSLCKALAQKltirlssryrygqlieinSHSLFskwFSESGKLVTKMF-----QKIQDLIDD--KDALV 247
Cdd:cd19501  40 VLLVGPPGTGKTLLAKAVAGE------------------AGVPF---FSISGSDFVEMFvgvgaSRVRDLFEQakKNAPC 98
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
5WC2_A      248 FVLIDAVESLTAARNACRAGTEPSDAiRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVA 308
Cdd:cd19501  99 IVFIDEIDAVGRKRGAGLGGGHDERE-QTLNQLLVEMDGFESNTGVIVIAATNRPDVLDPA 158
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
173-308 2.31e-06

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 49.38  E-value: 2.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A       173 RVVLLHGPPGTGKTSLCKALAQKLTirlssryryGQLIEINSHSLFSKWFSESGKLVTKMFQkiqdlIDDKDALVFVLID 252
Cdd:PTZ00454 180 RGVLLYGPPGTGKTMLAKAVAHHTT---------ATFIRVVGSEFVQKYLGEGPRMVRDVFR-----LARENAPSIIFID 245
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
5WC2_A       253 AVESLTAARNACRAGTEpSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVA 308
Cdd:PTZ00454 246 EVDSIATKRFDAQTGAD-REVQRILLELLNQMDGFDQTTNVKVIMATNRADTLDPA 300
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
149-308 2.43e-06

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 47.50  E-value: 2.43e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      149 LLDYVMTTLLFSDKNVNSNlITWNRVVLLHGPPGTGKTSLCKALA-------QKLTIRLssryRYGQlieinshSLFSKW 221
Cdd:cd19517  12 LKEMVFFPLLYPEVFAKFK-ITPPRGVLFHGPPGTGKTLMARALAaecskggQKVSFFM----RKGA-------DCLSKW 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      222 FSESGKLVTKMFQKIQDLiddKDALVFvlIDAVESLTAARNACRAGTEPSdairVVNAVLTQIDQIKRHSNVVILTTSNI 301
Cdd:cd19517  80 VGEAERQLRLLFEEAYRM---QPSIIF--FDEIDGLAPVRSSKQEQIHAS----IVSTLLALMDGLDNRGQVVVIGATNR 150

                ....*..
5WC2_A      302 TEKIDVA 308
Cdd:cd19517 151 PDALDPA 157
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
34-205 1.23e-05

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 47.46  E-value: 1.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A       34 KKEDINLSVRKLLNRHNIVFGDYTWTEFDEPFLTRNVQSVSIIDTELKVKDSQ--PIDLSACTVALHIFQLNEDGPSSEN 111
Cdd:COG1401  79 LLLDLEKVELNEKLALSEAAVAIEELYELEADSEIEAVGLLLELAERSDALEAleRARLLLELADLEERAALETEVLEAL 158
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      112 LEEETENIIAANHWVLPAAEFHGLWDSLVYDVEVKShLLDYVMTTLLFSDKNVNSNLITWNRV---VLLHGPPGTGKTSL 188
Cdd:COG1401 159 EAELEELLAAPEDLSADALAAELSAAEELYSEDLES-EDDYLKDLLREKFEETLEAFLAALKTkknVILAGPPGTGKTYL 237
                       170
                ....*....|....*..
5WC2_A      189 CKALAQKLTIRLSSRYR 205
Cdd:COG1401 238 ARRLAEALGGEDNGRIE 254
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
174-266 2.06e-05

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 44.52  E-value: 2.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      174 VVLLHGPPGTGKTSLCKALAQKL-TIRLSS---RYR-YGQLIEINSHSLfskwfSESGKLVTKMFQKIQDLIDDKdalVF 248
Cdd:COG0645   1 LILVCGLPGSGKSTLARALAERLgAVRLRSdvvRKRlFGAGLAPLERSP-----EATARTYARLLALARELLAAG---RS 72
                        90
                ....*....|....*...
5WC2_A      249 VLIDAVESLTAARNACRA 266
Cdd:COG0645  73 VILDATFLRRAQREAFRA 90
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
145-308 2.50e-05

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 44.49  E-value: 2.50e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      145 VKSHLLDYVMTTLLFSDknVNSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTirlssryryGQLIEINSHSLFSKWFSE 224
Cdd:cd19523   8 LKAAIKEEVLWPLLRPD--AFSGLLRLPRSILLFGPRGTGKTLLGRCLASQLG---------ATFLRLRGSTLVAKWAGE 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      225 SGKLVTKMFqkiqdLIDDKDALVFVLIDAVESLTAARNacrAGTEPSDAIRVvnAVLTQIDQI--KRHSNVVILTTSNIT 302
Cdd:cd19523  77 GEKILQASF-----LAARCRQPSVLFISDLDALLSSQD---DEASPVGRLQV--ELLAQLDGVlgSGEDGVLVVCTTSKP 146

                ....*.
5WC2_A      303 EKIDVA 308
Cdd:cd19523 147 EEIDES 152
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
175-332 2.73e-05

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 46.57  E-value: 2.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A       175 VLLHGPPGTGKTSLCKALAQKLTIrlssryrygqlieinshslfsKWFSESGKLVTKMF-----QKIQDLIDD--KDALV 247
Cdd:PRK10733 188 VLMVGPPGTGKTLLAKAIAGEAKV---------------------PFFTISGSDFVEMFvgvgaSRVRDMFEQakKAAPC 246
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A       248 FVLIDAVESLTAARNACRAGTEpSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFV--DRADIKQYIGPPSAA 325
Cdd:PRK10733 247 IIFIDEIDAVGRQRGAGLGGGH-DEREQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPALLrpGRFDRQVVVGLPDVR 325
                        170
                 ....*....|
5WC2_A       326 A---IFKIYL 332
Cdd:PRK10733 326 GreqILKVHM 335
AAA_22 pfam13401
AAA domain;
173-260 3.60e-05

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 43.10  E-value: 3.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A        173 RVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYRY-----GQLIEINsHSLFSKWFSESGKLVTK--MFQKIQDLIDDKDA 245
Cdd:pfam13401   6 GILVLTGESGTGKTTLLRRLLEQLPEVRDSVVFVdlpsgTSPKDLL-RALLRALGLPLSGRLSKeeLLAALQQLLLALAV 84
                          90
                  ....*....|....*
5WC2_A        246 LVFVLIDAVESLTAA 260
Cdd:pfam13401  85 AVVLIIDEAQHLSLE 99
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
169-196 5.59e-05

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 43.11  E-value: 5.59e-05
                        10        20
                ....*....|....*....|....*...
5WC2_A      169 ITWNRVVLLHGPPGTGKTSLCKALAQKL 196
Cdd:cd19510  20 IPYRRGYLLYGPPGTGKSSFIAALAGEL 47
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
175-193 8.79e-05

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 44.44  E-value: 8.79e-05
                         10
                 ....*....|....*....
5WC2_A       175 VLLHGPPGTGKTSLCKALA 193
Cdd:PRK03992 168 VLLYGPPGTGKTLLAKAVA 186
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
172-303 1.81e-04

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 42.60  E-value: 1.81e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      172 NRVVLLHGPPGTGKTSLCKALAQKLTIR------LSSRYRYGQLIEiNSHSL---FSKWFsESGKL-------------V 229
Cdd:COG0467  20 GSSTLLSGPPGTGKTTLALQFLAEGLRRgekglyVSFEESPEQLLR-RAESLgldLEEYI-ESGLLriidlspeelgldL 97
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
5WC2_A      230 TKMFQKIQDLIDDKDALVFVlIDaveSLTAARNacrAGTEPSDAIRVVNAVLTQIdqikRHSNVVILTTSNITE 303
Cdd:COG0467  98 EELLARLREAVEEFGAKRVV-ID---SLSGLLL---ALPDPERLREFLHRLLRYL----KKRGVTTLLTSETGG 160
AAA_18 pfam13238
AAA domain;
175-282 2.37e-04

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 40.87  E-value: 2.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A        175 VLLHGPPGTGKTSLCKALAQkltiRLSSRYRYGQLI-EINSHSLFSKWFSESGKLVTKMFQKIQDLIDDKDALVFVLIDA 253
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSK----RLGFGDNVRDLAlENGLVLGDDPETRESKRLDEDKLDRLLDLLEENAALEEGGNLI 76
                          90       100
                  ....*....|....*....|....*....
5WC2_A        254 VESltaarnaCRAGTEPSDAIRVVNAVLT 282
Cdd:pfam13238  77 IDG-------HLAELEPERAKDLVGIVLR 98
PRK04195 PRK04195
replication factor C large subunit; Provisional
173-193 3.16e-04

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 42.99  E-value: 3.16e-04
                         10        20
                 ....*....|....*....|.
5WC2_A       173 RVVLLHGPPGTGKTSLCKALA 193
Cdd:PRK04195  40 KALLLYGPPGVGKTSLAHALA 60
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
173-314 3.77e-04

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 40.59  E-value: 3.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      173 RVVLLHGPPGTGKTSLCKALAQKltirlsSRYRYGQLIEINSHSLfskwfseSGKLVTKMfQKIQDLIDDKDALVFVLID 252
Cdd:cd19512  23 RNILFYGPPGTGKTLFAKKLALH------SGMDYAIMTGGDVAPM-------GREGVTAI-HKVFDWANTSRRGLLLFVD 88
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
5WC2_A      253 AVESLTAARNAcragTEPSDAIR-VVNAVLTQIDQikrHSN-VVILTTSNITEKIDVAFVDRAD 314
Cdd:cd19512  89 EADAFLRKRST----EKISEDLRaALNAFLYRTGE---QSNkFMLVLASNQPEQFDWAINDRID 145
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
175-252 3.87e-04

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 42.53  E-value: 3.87e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A      175 VLLHGPPGTGKTSLCKALAQKLT-----------------IRLSSRYRYgqLIEINSHSLFSKWFSESGKLVTKMFQKIQ 237
Cdd:COG1474  54 VLIYGPTGTGKTAVAKYVLEELEeeaeergvdvrvvyvncRQASTRYRV--LSRILEELGSGEDIPSTGLSTDELFDRLY 131
                        90
                ....*....|....*...
5WC2_A      238 DLIDDKDA-LVFVL--ID 252
Cdd:COG1474 132 EALDERDGvLVVVLdeID 149
ftsH CHL00176
cell division protein; Validated
175-332 4.71e-04

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 42.34  E-value: 4.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A       175 VLLHGPPGTGKTSLCKALAQKLTIRLSSRyrygqlieinSHSLFSKWFSESGKL-VTKMFQKIQDliddkDALVFVLIDA 253
Cdd:CHL00176 219 VLLVGPPGTGKTLLAKAIAGEAEVPFFSI----------SGSEFVEMFVGVGAArVRDLFKKAKE-----NSPCIVFIDE 283
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A       254 VESLTAARNA-CRAGTEPSDaiRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFV--DRADIKQYIGPP---SAAAI 327
Cdd:CHL00176 284 IDAVGRQRGAgIGGGNDERE--QTLNQLLTEMDGFKGNKGVIVIAATNRVDILDAALLrpGRFDRQITVSLPdreGRLDI 361

                 ....*
5WC2_A       328 FKIYL 332
Cdd:CHL00176 362 LKVHA 366
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
174-202 6.78e-04

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 39.99  E-value: 6.78e-04
                          10        20        30
                  ....*....|....*....|....*....|
5WC2_A        174 VVLLHGPPGTGKTSLCKALAQKL-TIRLSS 202
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRLLEELgAVRLSS 30
cdc6 PRK00411
ORC1-type DNA replication protein;
135-252 1.98e-03

ORC1-type DNA replication protein;


Pssm-ID: 234751 [Multi-domain]  Cd Length: 394  Bit Score: 40.22  E-value: 1.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A       135 LWDSLVY-DVEVKSHllDYVMTTLLFSDKNVNS------NLITWNRV--VLLHGPPGTGKTSLCKAL---AQKLTIRLSS 202
Cdd:PRK00411  11 MWDETIFkDEEVLEP--DYVPENLPHREEQIEElafalrPALRGSRPlnVLIYGPPGTGKTTTVKKVfeeLEEIAVKVVY 88
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
5WC2_A       203 RY--------RYGQLIEINSHsLFSKWFSESGKLVTKMFQKIQDLIDDKDALVFVLID 252
Cdd:PRK00411  89 VYincqidrtRYAIFSEIARQ-LFGHPPPSSGLSFDELFDKIAEYLDERDRVLIVALD 145
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
175-202 2.08e-03

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 38.64  E-value: 2.08e-03
                          10        20        30
                  ....*....|....*....|....*....|
5WC2_A        175 VLLHGPPGTGKTSLCKALAQKL--TIRLSS 202
Cdd:pfam05496  36 VLLYGPPGLGKTTLANIIANEMgvNIRITS 65
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
175-196 2.27e-03

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 40.07  E-value: 2.27e-03
                         10        20
                 ....*....|....*....|..
5WC2_A       175 VLLHGPPGTGKTSLCKALAQKL 196
Cdd:PRK13342  39 MILWGPPGTGKTTLARIIAGAT 60
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
175-193 3.00e-03

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 40.02  E-value: 3.00e-03
                        10
                ....*....|....*....
5WC2_A      175 VLLHGPPGTGKTSLCKALA 193
Cdd:COG0465 178 VLLVGPPGTGKTLLAKAVA 196
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
175-196 3.07e-03

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 39.19  E-value: 3.07e-03
                        10        20
                ....*....|....*....|..
5WC2_A      175 VLLHGPPGTGKTSLCKALAQKL 196
Cdd:COG0470  21 LLLHGPPGIGKTTLALALARDL 42
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
173-296 3.41e-03

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 38.25  E-value: 3.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A        173 RVVLLHGPPGTGKTSLCKALAQkltiRLSSRYRYGQLIEINSHSLFSKWfsesgklvTKMFQKIQDLIDDKDALVFVLID 252
Cdd:pfam13191  25 PSVLLTGEAGTGKTTLLRELLR----ALERDGGYFLRGKCDENLPYSPL--------LEALTREGLLRQLLDELESSLLE 92
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
5WC2_A        253 AVESLTAARNACRAGTEPSDAIRVVNAVLTQIDQIKRHSNVVIL 296
Cdd:pfam13191  93 AWRAALLEALAPVPELPGDLAERLLDLLLRLLDLLARGERPLVL 136
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
175-196 3.45e-03

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


Pssm-ID: 459992  Cd Length: 102  Bit Score: 36.81  E-value: 3.45e-03
                          10        20
                  ....*....|....*....|..
5WC2_A        175 VLLHGPPGTGKTSLCKALAQKL 196
Cdd:pfam00910   1 IWLYGPPGCGKSTLAKYLARAL 22
NadR3 COG3172
Nicotinamide riboside kinase [Coenzyme transport and metabolism]; Nicotinamide riboside kinase ...
173-196 5.31e-03

Nicotinamide riboside kinase [Coenzyme transport and metabolism]; Nicotinamide riboside kinase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 442405 [Multi-domain]  Cd Length: 178  Bit Score: 37.88  E-value: 5.31e-03
                        10        20
                ....*....|....*....|....
5WC2_A      173 RVVLLhGPPGTGKTSLCKALAQKL 196
Cdd:COG3172  10 KIVLL-GAESTGKTTLARALAAHY 32
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
175-194 6.13e-03

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 38.88  E-value: 6.13e-03
                        10        20
                ....*....|....*....|
5WC2_A      175 VLLHGPPGTGKTSLCKALAQ 194
Cdd:COG2256  52 MILWGPPGTGKTTLARLIAN 71
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
175-194 7.53e-03

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 38.22  E-value: 7.53e-03
                        10        20
                ....*....|....*....|
5WC2_A      175 VLLHGPPGTGKTSLCKALAQ 194
Cdd:COG0714  34 LLLEGVPGVGKTTLAKALAR 53
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
173-196 7.66e-03

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 38.44  E-value: 7.66e-03
                          10        20
                  ....*....|....*....|....
5WC2_A        173 RVVLLHGPPGTGKTSLCKALAQKL 196
Cdd:pfam06068  51 RAVLIAGPPGTGKTALAIAISKEL 74
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
175-211 7.87e-03

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 38.19  E-value: 7.87e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
5WC2_A       175 VLLHGPPGTGKTSLCKALAQKL--TIRLSSryryGQLIE 211
Cdd:PRK00080  54 VLLYGPPGLGKTTLANIIANEMgvNIRITS----GPALE 88
DEXXQc_SETX cd18042
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in ...
164-187 8.50e-03

DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in transcription, neurogenesis, and antiviral response. SEXT is an R-loop-associated protein that is thought to function as an RNA/DNA helicase. R-loops consist of RNA/DNA hybrids, formed during transcription when nascent RNA hybridizes to the DNA template strand, displacing the non-template DNA strand. Mutations in SETX are linked to two neurodegenerative disorders: ataxia with oculomotor apraxia type 2 (AOA2) and amyotrophic lateral sclerosis type 4 (ALS4). S. cerevisiae homolog splicing endonuclease 1 (Sen1) is an exclusively nuclear protein, important for nucleolar organization. S. cerevisiae Sen1 and its ortholog, the Schizosaccharomyces pombe Sen1, share conserved domains and belong to the family I class of helicases. Both proteins translocate 5' to 3' and unwind both DNA and RNA duplexes and also RNA/DNA hybrids in vitro. SETX is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438712 [Multi-domain]  Cd Length: 218  Bit Score: 37.58  E-value: 8.50e-03
                        10        20
                ....*....|....*....|....
5WC2_A      164 VNSNLITWNRVVLLHGPPGTGKTS 187
Cdd:cd18042   9 IASALQNSPGITLIQGPPGTGKTK 32
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
174-196 8.59e-03

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 37.15  E-value: 8.59e-03
                        10        20
                ....*....|....*....|...
5WC2_A      174 VVLLHGPPGTGKTSLCKALAQKL 196
Cdd:cd19500  39 ILCLVGPPGVGKTSLGKSIARAL 61
recomb_radB TIGR02237
DNA repair and recombination protein RadB; This family consists exclusively of archaeal RadB ...
177-306 9.00e-03

DNA repair and recombination protein RadB; This family consists exclusively of archaeal RadB protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239) and DMC1 (TIGR02238), and archaeal RadA (TIGR02236).


Pssm-ID: 274047 [Multi-domain]  Cd Length: 209  Bit Score: 37.40  E-value: 9.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5WC2_A        177 LHGPPGTGKTSLCKALA------QKLTIRLS----SRYRYGQLIEINSHSLFSKW-------FSESGKLVTKMFqkiqDL 239
Cdd:TIGR02237  17 IYGPPGSGKTNICMILAvnaarqGKKVVYIDteglSPERFKQIAEDRPERALSNFivfevfdFDEQGVAIQKTS----KF 92
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
5WC2_A        240 IDDKDALVFVlidaVESLTAARNACRAGtEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKID 306
Cdd:TIGR02237  93 IDRDSASLVV----VDSFTALYRLELSD-DRISRNRELARQLTLLLSLARKKNLAVVITNQVYTDVN 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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