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Conserved domains on  [gi|1351638669|pdb|5X6J|A]
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Chain A, Adenylate kinase

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 11478412)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

CATH:  3.40.50.300
EC:  2.7.4.-
Gene Ontology:  GO:0050145|GO:0016310|GO:0046872
PubMed:  2841070
SCOP:  3002021

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
adk PRK00279
adenylate kinase; Reviewed
 1-215 2.36e-140

adenylate kinase; Reviewed


:

Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 390.66  E-value: 2.36e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         1 MNIVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSKSDCDNG 80
Cdd:PRK00279   1 MRLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A        81 FLLDGFPRTVPQAEALDQLLADMGRKIEHVLNIQVEKEELIARLTGRRICKVCGTSYHLLFNPPQVEGKCDKDGGELYQR 160
Cdd:PRK00279  81 FLLDGFPRTIPQAEALDEMLKELGIKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQR 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
5X6J_A       161 ADDNPDTVTNRLEVNMNQTAPLLAFYDSKEVLVNINGQKDIKDVFKDLDVILQGN 215
Cdd:PRK00279 161 ADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGKL 215
 
Name Accession Description Interval E-value
adk PRK00279
adenylate kinase; Reviewed
 1-215 2.36e-140

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 390.66  E-value: 2.36e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         1 MNIVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSKSDCDNG 80
Cdd:PRK00279   1 MRLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A        81 FLLDGFPRTVPQAEALDQLLADMGRKIEHVLNIQVEKEELIARLTGRRICKVCGTSYHLLFNPPQVEGKCDKDGGELYQR 160
Cdd:PRK00279  81 FLLDGFPRTIPQAEALDEMLKELGIKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQR 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
5X6J_A       161 ADDNPDTVTNRLEVNMNQTAPLLAFYDSKEVLVNINGQKDIKDVFKDLDVILQGN 215
Cdd:PRK00279 161 ADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGKL 215
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1-212 4.26e-139

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 387.56  E-value: 4.26e-139
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A        1 MNIVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSKSDCDNG 80
Cdd:COG0563   1 MRIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDCANG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A       81 FLLDGFPRTVPQAEALDQLLADMGRKIEHVLNIQVEKEELIARLTGRRICKVCGTSYHLLFNPPQVEGKCDKDGGELYQR 160
Cdd:COG0563  81 FILDGFPRTVAQAEALDELLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQR 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
5X6J_A      161 ADDNPDTVTNRLEVNMNQTAPLLAFYDSKEVLVNINGQKDIKDVFKDLDVIL 212
Cdd:COG0563 161 ADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
ADK pfam00406
Adenylate kinase;
5-189 4.58e-105

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 300.38  E-value: 4.58e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A          5 LMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSKSDCDNGFLLD 84
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKNGFLLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         85 GFPRTVPQAEALDQLLaDMGRKIEHVLNIQVEKEELIARLTGRRICKVCGTSYHLLFNPPQVEGKCDKDGGELYQRADDN 164
Cdd:pfam00406  81 GFPRTVPQAEALEELL-ERGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDN 159

                         170       180
                  ....*....|....*....|....*
5X6J_A        165 PDTVTNRLEVNMNQTAPLLAFYDSK 189
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYKKK 184
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 2-213 7.22e-104

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 298.38  E-value: 7.22e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A          2 NIVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSKS-DCDNG 80
Cdd:TIGR01351   1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNdDNENG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         81 FLLDGFPRTVPQAEALDQLLADmgrKIEHVLNIQVEKEELIARLTGRRICKVCGTSYHLLFNPPQVEGKCDKDGGELYQR 160
Cdd:TIGR01351  81 FILDGFPRTLSQAEALDALLEE---PIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQR 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
5X6J_A        161 ADDNPDTVTNRLEVNMNQTAPLLAFYDSKEVLVNINGQKDIKDVFKDLDVILQ 213
Cdd:TIGR01351 158 EDDTEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNGPIDEVWKRILEALK 210
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 2-204 3.36e-98

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 283.36  E-value: 3.36e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A        2 NIVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSKSDCDNGF 81
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKKGF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A       82 LLDGFPRTVPQAEALDQLLaDMGRKIEHVLNIQVEKEELIARLTGRRICKVCGTSYHLlfnppqveGKCDKDGGELYQRA 161
Cdd:cd01428  81 ILDGFPRTVDQAEALDELL-DEGIKPDKVIELDVPDEVLIERILGRRICPVSGRVYHL--------GKDDVTGEPLSQRS 151

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
5X6J_A      162 DDNPDTVTNRLEVNMNQTAPLLAFYDSKEVLVNINGQKDIKDV 204
Cdd:cd01428 152 DDNEETIKKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
 
Name Accession Description Interval E-value
adk PRK00279
adenylate kinase; Reviewed
 1-215 2.36e-140

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 390.66  E-value: 2.36e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         1 MNIVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSKSDCDNG 80
Cdd:PRK00279   1 MRLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A        81 FLLDGFPRTVPQAEALDQLLADMGRKIEHVLNIQVEKEELIARLTGRRICKVCGTSYHLLFNPPQVEGKCDKDGGELYQR 160
Cdd:PRK00279  81 FLLDGFPRTIPQAEALDEMLKELGIKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQR 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
5X6J_A       161 ADDNPDTVTNRLEVNMNQTAPLLAFYDSKEVLVNINGQKDIKDVFKDLDVILQGN 215
Cdd:PRK00279 161 ADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGKL 215
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1-212 4.26e-139

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 387.56  E-value: 4.26e-139
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A        1 MNIVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSKSDCDNG 80
Cdd:COG0563   1 MRIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDCANG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A       81 FLLDGFPRTVPQAEALDQLLADMGRKIEHVLNIQVEKEELIARLTGRRICKVCGTSYHLLFNPPQVEGKCDKDGGELYQR 160
Cdd:COG0563  81 FILDGFPRTVAQAEALDELLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQR 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
5X6J_A      161 ADDNPDTVTNRLEVNMNQTAPLLAFYDSKEVLVNINGQKDIKDVFKDLDVIL 212
Cdd:COG0563 161 ADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
ADK pfam00406
Adenylate kinase;
5-189 4.58e-105

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 300.38  E-value: 4.58e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A          5 LMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSKSDCDNGFLLD 84
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKNGFLLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         85 GFPRTVPQAEALDQLLaDMGRKIEHVLNIQVEKEELIARLTGRRICKVCGTSYHLLFNPPQVEGKCDKDGGELYQRADDN 164
Cdd:pfam00406  81 GFPRTVPQAEALEELL-ERGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDN 159

                         170       180
                  ....*....|....*....|....*
5X6J_A        165 PDTVTNRLEVNMNQTAPLLAFYDSK 189
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYKKK 184
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 2-213 7.22e-104

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 298.38  E-value: 7.22e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A          2 NIVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSKS-DCDNG 80
Cdd:TIGR01351   1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNdDNENG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         81 FLLDGFPRTVPQAEALDQLLADmgrKIEHVLNIQVEKEELIARLTGRRICKVCGTSYHLLFNPPQVEGKCDKDGGELYQR 160
Cdd:TIGR01351  81 FILDGFPRTLSQAEALDALLEE---PIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQR 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
5X6J_A        161 ADDNPDTVTNRLEVNMNQTAPLLAFYDSKEVLVNINGQKDIKDVFKDLDVILQ 213
Cdd:TIGR01351 158 EDDTEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNGPIDEVWKRILEALK 210
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 2-204 3.36e-98

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 283.36  E-value: 3.36e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A        2 NIVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSKSDCDNGF 81
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKKGF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A       82 LLDGFPRTVPQAEALDQLLaDMGRKIEHVLNIQVEKEELIARLTGRRICKVCGTSYHLlfnppqveGKCDKDGGELYQRA 161
Cdd:cd01428  81 ILDGFPRTVDQAEALDELL-DEGIKPDKVIELDVPDEVLIERILGRRICPVSGRVYHL--------GKDDVTGEPLSQRS 151

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
5X6J_A      162 DDNPDTVTNRLEVNMNQTAPLLAFYDSKEVLVNINGQKDIKDV 204
Cdd:cd01428 152 DDNEETIKKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
PRK14530 PRK14530
adenylate kinase; Provisional
 2-208 1.16e-65

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 201.94  E-value: 1.16e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         2 NIVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQE-----GTELGVkAKSFMDQGALVPDEVTIGIVRERLSKSD 76
Cdd:PRK14530   5 RILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRANKQMdisdmDTEYDT-PGEYMDAGELVPDAVVNEIVEEALSDAD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A        77 cdnGFLLDGFPRTVPQAEALDQLLAdmgrkIEHVLNIQVEKEELIARLTGRRICKVCGTSYHLLFNPPQVEGKCDKDGGE 156
Cdd:PRK14530  84 ---GFVLDGYPRNLEQAEYLESITD-----LDVVLYLDVSEEELVDRLTGRRVCPDCGANYHVEFNQPEEEGVCDECGGE 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
5X6J_A       157 LYQRADDNPDTVTNRLEVNMNQTAPLLAFYDSKEVLVNINGQKDIKDVFKDL 208
Cdd:PRK14530 156 LIQRDDDTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTPDEVWADI 207
PLN02674 PLN02674
adenylate kinase
 3-212 1.31e-65

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 202.81  E-value: 1.31e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         3 IVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSKSDCDNGFL 82
Cdd:PLN02674  34 LILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAMKKPSCQKGFI 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A        83 LDGFPRTVPQAEALDQLLADMGRKIEHVLNIQVEKEELIARLTGRRICKVCGTSYHLLFNPPQVEGKCDKDGGELYQRAD 162
Cdd:PLN02674 114 LDGFPRTVVQAQKLDEMLAKQGAKIDKVLNFAIDDAILEERITGRWIHPSSGRTYHTKFAPPKVPGVDDVTGEPLIQRKD 193

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
5X6J_A       163 DNPDTVTNRLEVNMNQTAPLLAFYDSKEVLVNINGQKDIKDVFKDLDVIL 212
Cdd:PLN02674 194 DTAAVLKSRLEAFHKQTEPVIDYYAKKGVVANLHAEKPPKEVTAEVQKAL 243
adk PRK02496
adenylate kinase; Provisional
 3-213 1.57e-64

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 197.66  E-value: 1.57e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         3 IVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSKSDCDNGFL 82
Cdd:PRK02496   4 LIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAANGWI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A        83 LDGFPRTVPQAEALDQLLADMGRKIEHVLNIQVEKEELIARLTGRrickvcgtsyhllfnppqvegkcdkdggelyQRAD 162
Cdd:PRK02496  84 LDGFPRKVTQAAFLDELLQEIGQSGERVVNLDVPDDVVVERLLAR-------------------------------GRKD 132

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
5X6J_A       163 DNPDTVTNRLEVNMNQTAPLLAFYDSKEVLVNINGQKDIKDVFKDLDVILQ 213
Cdd:PRK02496 133 DTEEVIRRRLEVYREQTAPLIDYYRDRQKLLTIDGNQSVEAVTTELKAALA 183
PRK13808 PRK13808
adenylate kinase; Provisional
 1-217 3.11e-64

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 202.04  E-value: 3.11e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         1 MNIVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSKSDCDNG 80
Cdd:PRK13808   1 MRLILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAANG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A        81 FLLDGFPRTVPQAEALDQLLADMGRKIEHVLNIQVEKEELIARLTgRRICKVcgtsyhllfnppqvegkcdKDGGElYQR 160
Cdd:PRK13808  81 FILDGFPRTVPQAEALDALLKDKQLKLDAVVELRVNEGALLARVE-TRVAEM-------------------RARGE-EVR 139

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
5X6J_A       161 ADDNPDTVTNRLEVNMNQTAPLLAFYDSKEVLVNINGQKDIKDVFKDLDVILQGNGQ 217
Cdd:PRK13808 140 ADDTPEVLAKRLASYRAQTEPLVHYYSEKRKLLTVDGMMTIDEVTREIGRVLAAVGA 196
PRK14528 PRK14528
adenylate kinase; Provisional
 2-204 1.22e-63

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 195.62  E-value: 1.22e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         2 NIVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSKSDCDNGF 81
Cdd:PRK14528   3 NIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCKNGF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A        82 LLDGFPRTVPQAEALDQLLADMGRKIEHVLNIQVEKEELIARLTGRRIckvcgtsyhllfnppqVEGkcdkdggelyqRA 161
Cdd:PRK14528  83 LLDGFPRTVEQADALDALLKNEGKSIDKAINLEVPDGELLKRLLGRAE----------------IEG-----------RA 135

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
5X6J_A       162 DDNPDTVTNRLEVNMNQTAPLLAFYDSKEVLVNINGQKDIKDV 204
Cdd:PRK14528 136 DDNEATIKNRLDNYNKKTLPLLDFYAAQKKLSQVNGVGSLEEV 178
PRK14532 PRK14532
adenylate kinase; Provisional
 1-214 2.60e-63

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 194.66  E-value: 2.60e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         1 MNIVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSKSDCDNG 80
Cdd:PRK14532   1 MNLILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERLPEAEAAGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A        81 FLLDGFPRTVPQAEALDQLLADMGRKIEHVLNIQVEKEELIARLTGRrickvcgtsyhllfnppqvegkcdkdgGELYQR 160
Cdd:PRK14532  81 AIFDGFPRTVAQAEALDKMLASRGQKIDVVIRLKVDDEALIERIVKR---------------------------FEEQGR 133

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
5X6J_A       161 ADDNPDTVTNRLEVNMNQTAPLLAFYDSKEVLVNINGQKDIKDVFKDLDVILQG 214
Cdd:PRK14532 134 PDDNPEVFVTRLDAYNAQTAPLLPYYAGQGKLTEVDGMGSIEAVAASIDAALEG 187
PRK14526 PRK14526
adenylate kinase; Provisional
 1-215 8.28e-52

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 166.18  E-value: 8.28e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         1 MNIVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSKSDCDNG 80
Cdd:PRK14526   1 MKLVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKNNDN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A        81 FLLDGFPRTVPQAEALDQLLADMgrkieHVLNIQVEKEELIARLTGRRICKVCGTSYHLLFNPPQVEGKCDKDGGELYQR 160
Cdd:PRK14526  81 FILDGFPRNINQAKALDKFLPNI-----KIINFLIDEELLIKRLSGRRICKSCNNIFNIYTLPTKEKGICDVCKGDLYQR 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
5X6J_A       161 ADDNPDTVTNRLEVNMNQTAPLLAFYDSKEVLVNINGQKDIKDVFKDL-DVILQGN 215
Cdd:PRK14526 156 KDDKEESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASKDIDEVKKKLiEIISKKN 211
PRK14527 PRK14527
adenylate kinase; Provisional
 3-206 2.09e-50

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 162.27  E-value: 2.09e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         3 IVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSKSDcDNGFL 82
Cdd:PRK14527   9 VIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDELAGME-PVRVI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A        83 LDGFPRTVPQAEALDQLLADMGRKIEHVLNIQVEKEELIARLTGRrickvcgtsyhllfnppqvegkcdkdgGELYQRAD 162
Cdd:PRK14527  88 FDGFPRTLAQAEALDRLLEELGARLLAVVLLEVPDEELIRRIVER---------------------------ARQEGRSD 140

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
5X6J_A       163 DNPDTVTNRLEVNMNQTAPLLAFYDSKEVLVNINGQKDIKDVFK 206
Cdd:PRK14527 141 DNEETVRRRQQVYREQTQPLVDYYEARGHLKRVDGLGTPDEVYA 184
PRK14531 PRK14531
adenylate kinase; Provisional
 3-212 4.85e-50

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 160.75  E-value: 4.85e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         3 IVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLsKSDCDNGFL 82
Cdd:PRK14531   5 LLFLGPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQL-KALNSGGWL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A        83 LDGFPRTVPQAEALDQLLADMGRKIEHVLNIQVEKEELIARLTGRrickvcgtsyhllfnppqvegkcdkdggelyQRAD 162
Cdd:PRK14531  84 LDGFPRTVAQAEALEPLLEELKQPIEAVVLLELDDAVLIERLLAR-------------------------------GRAD 132

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
5X6J_A       163 DNPDTVTNRLEVNMNQTAPLLAFYDSKEVLVNINGQKDIKDVFKDLDVIL 212
Cdd:PRK14531 133 DNEAVIRNRLEVYREKTAPLIDHYRQRGLLQSVEAQGSIEAITERIEKVL 182
PLN02842 PLN02842
nucleotide kinase
 7-212 1.09e-47

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 163.49  E-value: 1.09e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         7 GLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSKSD-CDNGFLLDG 85
Cdd:PLN02842   4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDaKEKGWLLDG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A        86 FPRTVPQAEALDQLladmgrKIEHVLNI--QVEKEELIARLTGRRICKVCGTSYHLLFNPPQVEgkcdKDGGELYQRADD 163
Cdd:PLN02842  84 YPRSFAQAQSLEKL------KIRPDIFIllDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPESE----EIKARLITRPDD 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
5X6J_A       164 NPDTVTNRLEVNMNQTAPLLAFYDSkeVLVNINGQKDIKDVFKDLDVIL 212
Cdd:PLN02842 154 TEEKVKARLQIYKKNAEAILSTYSD--IMVKIDGNRPKEVVFEEISSLL 200
PLN02459 PLN02459
probable adenylate kinase
 2-196 6.25e-47

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 155.39  E-value: 6.25e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         2 NIVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSK--SDCDN 79
Cdd:PLN02459  31 NWVFLGCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAgeEEGES 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A        80 GFLLDGFPRTVPQAEALDQLLadmgrKIEHVLNIQVEKEELIARLTGRRICKVCGTSYHL------------------LF 141
Cdd:PLN02459 111 GFILDGFPRTVRQAEILEGVT-----DIDLVVNLKLREEVLVEKCLGRRICSECGKNFNVadidlkgedgrpgivmppLL 185

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
5X6J_A       142 NPPQVEGKcdkdggeLYQRADDNPDTVTNRLEVNMNQTAPLLAFYDSKEVLVNIN 196
Cdd:PLN02459 186 PPPECASK-------LITRADDTEEVVKARLRVYKEESQPVEDFYRKRGKLLEFE 233
PRK14529 PRK14529
adenylate kinase; Provisional
 1-208 4.07e-45

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 149.48  E-value: 4.07e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         1 MNIVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLsKSDCDNG 80
Cdd:PRK14529   1 MNILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETL-KQDGKNG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A        81 FLLDGFPRTVPQAEALDQLLADMGRKIEHVLNIQVEKEELIARLTGRRICKVCGTSYHLLF----NPpqVEGKCDKDGGE 156
Cdd:PRK14529  80 WLLDGFPRNKVQAEKLWEALQKEGMKLDYVIEILLPREVAKNRIMGRRLCKNDNNHPNNIFidaiKP--DGDVCRVCGGE 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
5X6J_A       157 LYQRADDNPDTVTN-RLEVNMN-QTAPLLAFYDSKEV-------LVNINGQKDIKDVFKDL 208
Cdd:PRK14529 158 LSTRADDQDEEAINkRHDIYYDtETGTLAAAYFFKDLaakgstkYIELDGEGSIDEIKETL 218
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 3-205 1.86e-41

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 139.18  E-value: 1.86e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A          3 IVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSKS-DCDNGF 81
Cdd:TIGR01360   6 IFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAAlGTSKGF 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         82 LLDGFPRTVPQAEaldqllaDMGRKIEH---VLNIQVEKEELIARLTGRrickvcgtsyhllfnppqvegkcdkdgGELY 158
Cdd:TIGR01360  86 LIDGYPREVKQGE-------EFERRIGPptlVLYFDCSEDTMVKRLLKR---------------------------AETS 131

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
5X6J_A        159 QRADDNPDTVTNRLEVNMNQTAPLLAFYDSKEVLVNINGQKDIKDVF 205
Cdd:TIGR01360 132 GRVDDNEKTIKKRLETYYKATEPVIAYYETKGKLRKINAEGTVDDVF 178
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 1-212 7.80e-40

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 136.08  E-value: 7.80e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         1 MNIVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSK--SDCD 78
Cdd:PTZ00088   7 LKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKvtDDCF 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A        79 NGFLLDGFPRTVPQAEALDQLladmgRKIEHVLNIQVEKEELIARLTGRRICKVCG----------TSYHLL-FNPPQve 147
Cdd:PTZ00088  87 KGFILDGFPRNLKQCKELGKI-----TNIDLFVNIYLPRNILIKKLLGRRICNTCNrnfniahirsDPYDMPpILPPA-- 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
5X6J_A       148 gKCDKDGG--ELYQRADDNPDTVTNRLEVNMNQTAPLLAFY-DSKEVLVNINGQKDIKDvFKDLDVIL 212
Cdd:PTZ00088 160 -DCEGCKGnpKLQKRSDDTEEIVAHRLNTYESTNSPIIQFFkNENCNLVDFEITRGLRD-FDDFYRIV 225
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 6-212 1.85e-37

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 128.64  E-value: 1.85e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A          6 MGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQ-EGTELGVKAKSFMDQGALVPDEVTIGIVRERLSKSDCDNGFLLD 84
Cdd:TIGR01359   5 LGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKrEGSENGSLIESYIKEGKIVPSEVTVELLKKAIQEDGSSKKFLID 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         85 GFPRTvpqAEALDQLLADMGRKIE--HVLNIQVEKEELIARLTGRrickvcgtsyhllfnppqvegkcdkdgGELYQRAD 162
Cdd:TIGR01359  85 GFPRN---EENLEAWEKLMDNKVNfkFVLFFDCPEETMIKRLLKR---------------------------GQTSGRVD 134

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
5X6J_A        163 DNPDTVTNRLEVNMNQTAPLLAFYDSKEVLVNINGQKDIKDVFKDLDVIL 212
Cdd:TIGR01359 135 DNIETLKKRFRTYNEETLPIIEHFENKGKVKEINAEGSVEEVFEDVEKIF 184
AAA_17 pfam13207
AAA domain;
6-128 4.11e-37

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 126.20  E-value: 4.11e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A          6 MGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTelGVKAKSFMDQGALVPDEVTIGIVRERLSKSDCDNGFLLDG 85
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAERIAEEAGEGGVIVDG 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
5X6J_A         86 FPRTVPQAEALDQLLADMGRKIE--HVLNIQVEKEELIARLTGRR 128
Cdd:pfam13207  79 HPRIKTPAGYLPGLPVEVLRELKpdAIILLEADPEEILERRLKDR 123
PLN02200 PLN02200
adenylate kinase family protein
 5-206 4.49e-27

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 103.43  E-value: 4.49e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A         5 LMGLPGAGKGTQADRIVEKYGIPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVPDEVTIGIVRERLSKSDcDNGFLLD 84
Cdd:PLN02200  48 VLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESSD-NNKFLID 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A        85 GFPRTVPQAEALDQLLadmGRKIEHVLNIQVEKEELIARLTGRRickvcgtsyhllfnppqvEGkcdkdggelyqRADDN 164
Cdd:PLN02200 127 GFPRTEENRIAFERII---GAEPNVVLFFDCPEEEMVKRVLNRN------------------QG-----------RVDDN 174

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
5X6J_A       165 PDTVTNRLEVNMNQTAPLLAFYDSKEVLVNINGQKDIKDVFK 206
Cdd:PLN02200 175 IDTIKKRLKVFNALNLPVIDYYSKKGKLYTINAVGTVDEIFE 216
ADK_lid pfam05191
Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular ...
 127-162 3.57e-19

Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. In some organizms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain, is clearly structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely structural function.


Pssm-ID: 461578 [Multi-domain]  Cd Length: 36  Bit Score: 77.12  E-value: 3.57e-19
                          10        20        30
                  ....*....|....*....|....*....|....*.
5X6J_A        127 RRICKVCGTSYHLLFNPPQVEGKCDKDGGELYQRAD 162
Cdd:pfam05191   1 RRVCPKCGRIYHVYFNPPKVEGVCDVCGGELVQRDD 36
PRK04182 PRK04182
cytidylate kinase; Provisional
 1-36 4.22e-08

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 50.96  E-value: 4.22e-08
                         10        20        30
                 ....*....|....*....|....*....|....*.
5X6J_A         1 MNIVLMGLPGAGKGTQADRIVEKYGIPHISTGDMFR 36
Cdd:PRK04182   1 MIITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFR 36
PRK01184 PRK01184
flagellar hook-basal body complex protein FliE;
1-41 1.03e-05

flagellar hook-basal body complex protein FliE;


Pssm-ID: 234914 [Multi-domain]  Cd Length: 184  Bit Score: 44.55  E-value: 1.03e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
5X6J_A         1 MNIVLMGLPGAGKGtQADRIVEKYGIPHISTGDMFRAAIQE 41
Cdd:PRK01184   2 KIIGVVGMPGSGKG-EFSKIAREMGIPVVVMGDVIREEVKK 41
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 3-127 1.56e-05

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 43.45  E-value: 1.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A          3 IVLMGLPGAGKGTQADRIVEKYGIPHISTgDMFRAAIQeGTELGVKAKSfMDQGALVPdEVTIGIVRERLS-KSDC--DN 79
Cdd:pfam13671   2 ILLVGLPGSGKSTLARRLLEELGAVRLSS-DDERKRLF-GEGRPSISYY-TDATDRTY-ERLHELARIALRaGRPVilDA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
5X6J_A         80 GFLldgfprTVPQAEALDQLLADMGRKIEHVLnIQVEKEELIARLTGR 127
Cdd:pfam13671  78 TNL------RRDERARLLALAREYGVPVRIVV-FEAPEEVLRERLAAR 118
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 3-34 9.64e-05

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 40.93  E-value: 9.64e-05
                        10        20        30
                ....*....|....*....|....*....|..
5X6J_A        3 IVLMGLPGAGKGTQADRIVEKYGIPHISTGDM 34
Cdd:cd02020   2 IAIDGPAGSGKSTVAKLLAKKLGLPYLDTGGI 33
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
3-128 1.75e-04

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 40.67  E-value: 1.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5X6J_A        3 IVLMGLPGAGKGTQADRIVEKYGIPHIST----GDMFRAAIQEGTElgvkaksFMDQGALVpDEVTIGIVRERLsksdcD 78
Cdd:COG0645   2 ILVCGLPGSGKSTLARALAERLGAVRLRSdvvrKRLFGAGLAPLER-------SPEATART-YARLLALARELL-----A 68

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
5X6J_A       79 NGF--LLD-GFPRtVPQAEALDQLLADMGRKIeHVLNIQVEKEELIARLTGRR 128
Cdd:COG0645  69 AGRsvILDaTFLR-RAQREAFRALAEEAGAPF-VLIWLDAPEEVLRERLEARN 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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