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Chain B, Aprataxin
aprataxin_related and zf-C2HE domain-containing protein( domain architecture ID 10841342)
aprataxin_related and zf-C2HE domain-containing protein
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
aprataxin_related | cd01278 | aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia ... |
5-105 | 1.92e-46 | |||
aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are predominantly eukaryotic in origin. : Pssm-ID: 238609 [Multi-domain] Cd Length: 104 Bit Score: 147.53 E-value: 1.92e-46
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zf-C2HE | pfam16278 | C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in ... |
123-182 | 8.82e-19 | |||
C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in fungi, plants and metazoa. It is often found at the C-terminus of HIT-domain-containing proteins, pfam01230. In fungi the fourth ligand is a Glu, in plants it is Cys and in metazoans it is usually a His. The fourth ligand is often mutated in neurogenerative disease-states. : Pssm-ID: 465082 Cd Length: 60 Bit Score: 75.79 E-value: 8.82e-19
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Name | Accession | Description | Interval | E-value | |||
aprataxin_related | cd01278 | aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia ... |
5-105 | 1.92e-46 | |||
aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are predominantly eukaryotic in origin. Pssm-ID: 238609 [Multi-domain] Cd Length: 104 Bit Score: 147.53 E-value: 1.92e-46
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DcpS_C | pfam11969 | Scavenger mRNA decapping enzyme C-term binding; This family consists of several scavenger mRNA ... |
13-118 | 6.45e-38 | |||
Scavenger mRNA decapping enzyme C-term binding; This family consists of several scavenger mRNA decapping enzymes (DcpS) and is the C-terminal region. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' decay of an mRNA. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The C-terminal domain contains a histidine triad (HIT) sequence with three histidines separated by hydrophobic residues. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function. Pssm-ID: 463415 [Multi-domain] Cd Length: 114 Bit Score: 126.18 E-value: 6.45e-38
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zf-C2HE | pfam16278 | C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in ... |
123-182 | 8.82e-19 | |||
C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in fungi, plants and metazoa. It is often found at the C-terminus of HIT-domain-containing proteins, pfam01230. In fungi the fourth ligand is a Glu, in plants it is Cys and in metazoans it is usually a His. The fourth ligand is often mutated in neurogenerative disease-states. Pssm-ID: 465082 Cd Length: 60 Bit Score: 75.79 E-value: 8.82e-19
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HinT | COG0537 | Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide ... |
13-104 | 9.28e-06 | |||
Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide transport and metabolism, General function prediction only]; Pssm-ID: 440303 [Multi-domain] Cd Length: 133 Bit Score: 43.40 E-value: 9.28e-06
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Name | Accession | Description | Interval | E-value | |||
aprataxin_related | cd01278 | aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia ... |
5-105 | 1.92e-46 | |||
aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are predominantly eukaryotic in origin. Pssm-ID: 238609 [Multi-domain] Cd Length: 104 Bit Score: 147.53 E-value: 1.92e-46
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DcpS_C | pfam11969 | Scavenger mRNA decapping enzyme C-term binding; This family consists of several scavenger mRNA ... |
13-118 | 6.45e-38 | |||
Scavenger mRNA decapping enzyme C-term binding; This family consists of several scavenger mRNA decapping enzymes (DcpS) and is the C-terminal region. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' decay of an mRNA. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The C-terminal domain contains a histidine triad (HIT) sequence with three histidines separated by hydrophobic residues. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function. Pssm-ID: 463415 [Multi-domain] Cd Length: 114 Bit Score: 126.18 E-value: 6.45e-38
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zf-C2HE | pfam16278 | C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in ... |
123-182 | 8.82e-19 | |||
C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in fungi, plants and metazoa. It is often found at the C-terminus of HIT-domain-containing proteins, pfam01230. In fungi the fourth ligand is a Glu, in plants it is Cys and in metazoans it is usually a His. The fourth ligand is often mutated in neurogenerative disease-states. Pssm-ID: 465082 Cd Length: 60 Bit Score: 75.79 E-value: 8.82e-19
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HIT | pfam01230 | HIT domain; |
22-109 | 1.83e-06 | |||
HIT domain; Pssm-ID: 395984 [Multi-domain] Cd Length: 98 Bit Score: 44.22 E-value: 1.83e-06
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HinT | COG0537 | Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide ... |
13-104 | 9.28e-06 | |||
Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide transport and metabolism, General function prediction only]; Pssm-ID: 440303 [Multi-domain] Cd Length: 133 Bit Score: 43.40 E-value: 9.28e-06
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HIT_like | cd00468 | HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH ... |
22-104 | 1.48e-04 | |||
HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified in the literacture into three major branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the Fhit branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases. Further sequence analysis reveals several new closely related, yet uncharacterized subgroups. Pssm-ID: 238263 [Multi-domain] Cd Length: 86 Bit Score: 38.99 E-value: 1.48e-04
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