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Conserved domains on  [gi|1790883866|pdb|6TO7|B]
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Chain B, Orexin receptor type 1

Protein Classification

G protein-coupled receptor family protein; olfactory receptor( domain architecture ID 11606955)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters; olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
23-313 1.50e-164

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


:

Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 460.70  E-value: 1.50e-164
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       23 WVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQ 102
Cdd:cd15208   1 WVLIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      103 AVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPeLAARTRAFSVCDERW 182
Cdd:cd15208  81 TVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARVSILIIWIVSLLIMIPQAIVMECSRVVP-LANKTILLTVCDERW 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      183 ADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTS---------------AEVKQMRARRKTAKMLMVV 247
Cdd:cd15208 160 SDSIYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSvvqrkwnkprksavaAEEKQLRSRRKTAKMLIVV 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
6TO7_B      248 VLVFALCYLPISVLNVLKRVFGMFrqASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15208 240 VIMFAICYLPVHLLNILRYVFGLF--TVDRETIYAWFLFSHWLVYANSAINPIIYNFMSGKFREEF 303
 
Name Accession Description Interval E-value
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
23-313 1.50e-164

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 460.70  E-value: 1.50e-164
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       23 WVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQ 102
Cdd:cd15208   1 WVLIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      103 AVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPeLAARTRAFSVCDERW 182
Cdd:cd15208  81 TVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARVSILIIWIVSLLIMIPQAIVMECSRVVP-LANKTILLTVCDERW 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      183 ADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTS---------------AEVKQMRARRKTAKMLMVV 247
Cdd:cd15208 160 SDSIYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSvvqrkwnkprksavaAEEKQLRSRRKTAKMLIVV 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
6TO7_B      248 VLVFALCYLPISVLNVLKRVFGMFrqASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15208 240 VIMFAICYLPVHLLNILRYVFGLF--TVDRETIYAWFLFSHWLVYANSAINPIIYNFMSGKFREEF 303
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
39-302 1.27e-56

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 184.42  E-value: 1.27e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B         39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDIT-ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B        118 LDRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQaAVMECSSVLPElaartRAFSVCDERWADDLA-PKIYHSC 194
Cdd:pfam00001  81 IDRYLAIVHPLRYKRrrTPRRAKVLILVIWVLALLLSLPP-LLFGWTLTVPE-----GNVTVCFIDFPEDLSkPVSYTLL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B        195 FFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQmraRRKTAKMLMVVVLVFALCYLPISVLNVLkRVFgmFRQA 274
Cdd:pfam00001 155 ISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSSERTQR---RRKALKTLAVVVVVFILCWLPYHIVNLL-DSL--ALDC 228
                         250       260
                  ....*....|....*....|....*...
6TO7_B        275 SDREAVYAAFTFSHWLVYANSAANPIIY 302
Cdd:pfam00001 229 ELSRLLDKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
39-315 2.49e-14

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 72.89  E-value: 2.49e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B        39 GNTLVcLAVWRNHHMRTVTNYFLVNLSLADVLATAIcLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:PHA03087  57 GNIIV-IYVLTKTKIKTPMDIYLLNLAVSDLLFVMT-LPFQIYYYILFQWSFGEFACKIVSGLYYIGFYNSMNFITVMSV 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELaartrafsVCDERWADD---LAPKI-YH 192
Cdd:PHA03087 135 DRYIAIVHPVKSNKinTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETL--------ICCMFYNNKtmnWKLFInFE 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       193 SCFFivTYLAPLGLMAMAYFQIFRKLWGRQIPgttsaevkqmRARRKTAKMLMVVVLVFALCYLP--ISVLNVLKRVFGM 270
Cdd:PHA03087 207 INII--GMLIPLTILLYCYSKILITLKGINKS----------KKNKKAIKLVLIIVILFVIFWLPfnVSVFVYSLHILHF 274
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
6TO7_B       271 FRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKA 315
Cdd:PHA03087 275 KSGCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKK 319
 
Name Accession Description Interval E-value
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
23-313 1.50e-164

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 460.70  E-value: 1.50e-164
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       23 WVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQ 102
Cdd:cd15208   1 WVLIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      103 AVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPeLAARTRAFSVCDERW 182
Cdd:cd15208  81 TVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARVSILIIWIVSLLIMIPQAIVMECSRVVP-LANKTILLTVCDERW 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      183 ADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTS---------------AEVKQMRARRKTAKMLMVV 247
Cdd:cd15208 160 SDSIYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSvvqrkwnkprksavaAEEKQLRSRRKTAKMLIVV 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
6TO7_B      248 VLVFALCYLPISVLNVLKRVFGMFrqASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15208 240 VIMFAICYLPVHLLNILRYVFGLF--TVDRETIYAWFLFSHWLVYANSAINPIIYNFMSGKFREEF 303
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
39-313 4.13e-99

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 294.51  E-value: 4.13e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd14993  17 GNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQGVSVSASVLTLVAISI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFK--STARRALGSILGIWAVSLAIMVPQAAVMECSSvLPELAARTRAFSVCDERWADDLAPKIYHSCFF 196
Cdd:cd14993  97 DRYLAICYPLKARrvSTKRRARIIIVAIWVIAIIIMLPLLVVYELEE-IISSEPGTITIYICTEDWPSPELRKAYNVALF 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKLWGRQIPGTT-----SAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMF 271
Cdd:cd14993 176 VVLYVLPLLIISVAYSLIGRRLWRRKPPGDRgsansTSSRRILRSKKKVARMLIVVVVLFALSWLPYYVLSILLDFGPLS 255
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
6TO7_B      272 RQASDrEAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd14993 256 SEESD-ENFLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
39-313 4.19e-84

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 256.01  E-value: 4.19e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15207  17 GNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTGWPFGDVMCKLSPLVQGVSVAASVFTLVAIAV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMEcssVLPELAARTRAFSVCDERWADDLAPKIYHSCFFIV 198
Cdd:cd15207  97 DRYRAVVHPTEPKLTNRQAFVIIVAIWVLALAIMIPQALVLE---VKEYQFFRGQTVHICVEFWPSDEYRKAYTTSLFVL 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      199 TYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVK----QMRARRKTAKMLMVVVLVFALCYLPISVLNVLKrVFGMFrQA 274
Cdd:cd15207 174 CYVAPLLIIAVLYVRIGYRLWFKPVPGGGSASREaqaaVSKKKVRVIKMLIVVVVLFALSWLPLHTVTMLD-DFGNL-SP 251
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
6TO7_B      275 SDREAVYA-AFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15207 252 NQREVLYVyIYPIAHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
39-306 1.17e-66

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 210.61  E-value: 1.17e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd00637  15 GNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTLTAISV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVMECSSVLPElaartrafSVCDERWADDLAPKIYHSCFF 196
Cdd:cd00637  95 DRYLAIVHPLRYRRrfTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGY--------CCCCLCWPDLTLSKAYTIFLF 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKLWGRQIPG----TTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFR 272
Cdd:cd00637 167 VLLFLLPLLVIIVCYVRIFRKLRRHRRRIrsssSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVFGPDPS 246
                       250       260       270
                ....*....|....*....|....*....|....
6TO7_B      273 QASdreavYAAFTFSHWLVYANSAANPIIYNFLS 306
Cdd:cd00637 247 PLP-----RILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
39-313 2.87e-62

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 200.14  E-value: 2.87e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15203  17 GNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKLVPSLQGVSIFVSTLTLTAIAI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMEcSSVLPELAARTRAfSVCDERWADDLAPKIYHSCFFIV 198
Cdd:cd15203  97 DRYQLIVYPTRPRMSKRHALLIIALIWILSLLLSLPLAIFQE-LSDVPIEILPYCG-YFCTESWPSSSSRLIYTISVLVL 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      199 TYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQMRAR------RKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFR 272
Cdd:cd15203 175 QFVIPLLIISFCYFRISLKLRKRVKKKRGKRTLSSRRRRselrrkRRTNRLLIAMVVVFAVCWLPLNLFNLLRDFEPLPQ 254
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
6TO7_B      273 QasDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15203 255 I--DGRHFYLIFLICHLIAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
39-313 3.74e-62

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 199.51  E-value: 3.74e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLL-VDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15392  17 GNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIaLLILQYWPFGEFMCPVVNYLQAVSVFVSAFTLVAIS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVmecSSVLPELAARTRAfSVCDERWADDLAPKIYHSCFFI 197
Cdd:cd15392  97 IDRYVAIMWPLRPRMTKRQALLLIAVIWIFALATALPIAIT---SRLFEDSNASCGQ-YICTESWPSDTNRYIYSLVLMI 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      198 VTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSA--EVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFgmFRQAS 275
Cdd:cd15392 173 LQYFVPLAVLVFTYTRIGIVVWAKRTPGEAENnrDQRMAESKRKLVKMMITVVAIFALCWLPLNILNLVGDHD--ESIYS 250
                       250       260       270
                ....*....|....*....|....*....|....*...
6TO7_B      276 DREAVYAAFTFsHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15392 251 WPYIPYLWLAA-HWLAMSHCCYNPFIYCWMNAKFRNGF 287
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
39-313 2.22e-58

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 189.80  E-value: 2.22e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15095  17 GNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGDFMCKFVNYMMQVTVQATCLTLTALSV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPL--LFKSTARRALGSILGIWAVSLAIMVPQAAVMEcssVLPELAARTRAFsvCDERWADDLAPKIYHSCFF 196
Cdd:cd15095  97 DRYYAIVHPIrsLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYR---LEEGYWYGPQTY--CREVWPSKAFQKAYMIYTV 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKLWGRQIPG---TTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQ 273
Cdd:cd15095 172 LLTYVIPLAIIAVCYGLILRRLWRRSVDGnnqSEQLSERALRQKRKVTRMVIVVVVLFAICWLPNHVLNLWQRFDPNFPE 251
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
6TO7_B      274 AsdrEAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15095 252 T---YATYALKIAALCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
39-313 2.51e-57

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 187.12  E-value: 2.51e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15390  17 GNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITTVAASVFTLMAISI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAavmecssvlpeLAARTRAFS--------VCDERWADD---LA 187
Cdd:cd15390  97 DRYIAIVHPLRPRLSRRTTKIAIAVIWLASFLLALPQL-----------LYSTTETYYyytgsertVCFIAWPDGpnsLQ 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      188 PKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPG-TTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKR 266
Cdd:cd15390 166 DFVYNIVLFVVTYFLPLIIMAVAYTRVGVELWGSKTIGeNTPRQLESVRAKRKVVKMMIVVVVIFAICWLPYHLYFILTY 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
6TO7_B      267 VFGMFRQASDREAVYAAFtfsHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15390 246 LYPDINSWKYIQQIYLAI---YWLAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
39-313 3.15e-57

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 186.84  E-value: 3.15e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15393  17 GNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVNVSVFTLTVIAV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTRAFsvCDERWADDLAPKIYHSCFFIV 198
Cdd:cd15393  97 DRYRAVIHPLKARCSKKSAKIIILIIWILALLVALPVALALRVEELTDKTNNGVKPF--CLPVGPSDDWWKIYNLYLVCV 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      199 TYLAPLGLMAMAYFQIFRKLWGRQIPGTT--SAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVfgmFRQASD 276
Cdd:cd15393 175 QYFVPLVIICYAYTRIAVKIWGTKAPGNAqdVRDDEILKNKKKVIKMLIIVVALFALCWLPLQTYNLLNEI---KPEINK 251
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      277 REAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15393 252 YKYINIIWFCSHWLAMSNSCYNPFIYGLYNEKFKREF 288
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
39-302 1.27e-56

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 184.42  E-value: 1.27e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B         39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDIT-ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B        118 LDRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQaAVMECSSVLPElaartRAFSVCDERWADDLA-PKIYHSC 194
Cdd:pfam00001  81 IDRYLAIVHPLRYKRrrTPRRAKVLILVIWVLALLLSLPP-LLFGWTLTVPE-----GNVTVCFIDFPEDLSkPVSYTLL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B        195 FFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQmraRRKTAKMLMVVVLVFALCYLPISVLNVLkRVFgmFRQA 274
Cdd:pfam00001 155 ISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSSERTQR---RRKALKTLAVVVVVFILCWLPYHIVNLL-DSL--ALDC 228
                         250       260
                  ....*....|....*....|....*...
6TO7_B        275 SDREAVYAAFTFSHWLVYANSAANPIIY 302
Cdd:pfam00001 229 ELSRLLDKALSVTLWLAYVNSCLNPIIY 256
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
39-313 1.68e-56

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 185.02  E-value: 1.68e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15202  17 GNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVHVSAYTLTAIAV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAvmeCSSVLPELAARTRAFSVCDERWAD--DLAPKIYHSCFF 196
Cdd:cd15202  97 DRYQAIMHPLKPRISKTKAKFIIAVIWTLALAFALPHAI---CSKLETFKYSEDIVRSLCLEDWPEraDLFWKYYDLALF 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKLWGRQIPG--TTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFgMFRQA 274
Cdd:cd15202 174 ILQYFLPLLVISFAYARVGIKLWASNMPGdaTTERYFALRRKKKKVIKMLMVVVVLFALCWLPFNIYVLLLSSK-PDYLI 252
                       250       260       270
                ....*....|....*....|....*....|....*....
6TO7_B      275 SDREAVYAAFtfsHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15202 253 KTINAVYFAF---HWLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
39-313 7.21e-54

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 178.64  E-value: 7.21e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLL-VDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd14997  17 GNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVeTWAREPWLLGEFMCKLVPFVELTVAHASVLTILAIS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVMECSSvlpELAARTRAFSVCDERwADDLAPKIYHSCF 195
Cdd:cd14997  97 FERYYAICHPLQAKYvcTKRRALVIIALIWLLALLTSSPVLFITEFKE---EDFNDGTPVAVCRTP-ADTFWKVAYILST 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKLWGR---QIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPIsvlnvlkRVFGMF- 271
Cdd:cd14997 173 IVVFFVVPLAILSGLYSVICRRLVGHpalESRRADAANRHTLRSRRQVVYMLITVVVLFFVCLLPF-------RVVTLWi 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
6TO7_B      272 -------RQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd14997 246 ifapdedLQALGLEGYLNLLVFCRVMVYLNSALNPILYNLMSTKFRSAF 294
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
39-313 8.46e-54

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 178.40  E-value: 8.46e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd14992  17 GNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYASSLTLTAIAF 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVmecSSVLPELAARTRAFSVCDERW--ADDLAPKIYHSC 194
Cdd:cd14992  97 DRYFAIIHPLKPRHrqSYTTTVIIIITIWVVSLLLAIPQLYY---ATTEVLFSVKNQEKIFCCQIPpvDNKTYEKVYFLL 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEV--KQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFR 272
Cdd:cd14992 174 IFVVIFVLPLIVMTLAYARISRELWFRKVPGFSIKEVerKRLKCKRRVIKMLVCVVVLFVICWLPFHLFFLLRDFFPLIM 253
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
6TO7_B      273 QASDREAVYAaftFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd14992 254 KEKHTLQVYY---FLHWIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
39-313 6.25e-52

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 173.04  E-value: 6.25e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd14971  17 GNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSMHASIFTLVAMSL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVMECSSVLPelaartRAFSVCDERWADDLAPKIYHSCFF 196
Cdd:cd14971  97 DRFLAVVYPLRSLHirTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTP------GNRTVCSEAWPSRAHRRAFALCTF 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKqmRARRKTAKMLMVVVLVFALCYLPISVLNVLKRvfgmFRQASD 276
Cdd:cd14971 171 LFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSR--RAKRKVTRLVLVVVVLFAACWGPIHAILLLVA----LGPFPL 244
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      277 REAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd14971 245 TYATYALRIWAHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
39-313 8.15e-52

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 172.87  E-value: 8.15e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15096  17 GNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASVYTLVLMSL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARtrafSVCDERWADDLAPKIYHSCFF 196
Cdd:cd15096  97 DRYLAVVHPITSMSirTERNTLIAIVGIWIVILVANIPVLFLHGVVSYGFSSEAY----SYCTFLTEVGTAAQTFFTSFF 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKLWgRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRvfgmFRQASD 276
Cdd:cd15096 173 LFSYLIPLTLICVLYMLMLRRLR-RQKSPGGRRSAESQRGKRRVTRLVVVVVVVFAICWLPIHIILLLKY----YGVLPE 247
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      277 REAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15096 248 TVLYVVIQILSNCLAYGNSCVNPILYAFLSQNFRKAF 284
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
23-313 1.95e-51

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 171.42  E-value: 1.95e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       23 WVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQ 102
Cdd:cd15206   1 ELIIPLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      103 AVSVSVAVLTLSFIALDRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVmecSSVLPELAARTRAfsvCDE 180
Cdd:cd15206  81 AVSVSVSTFTLVAISLERYFAICHPLKSRVwqTLSHAYKVIAGIWLLSFLIMSPILVF---SNLIPMSRPGGHK---CRE 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      181 RWADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsaevkqmRARRKTAKMLMVVVLVFALCYLPISV 260
Cdd:cd15206 155 VWPNEIAEQAWYVFLDLMLLVIPGLVMSVAYGLISWTLL---------------EAKKRVIRMLFVIVVEFFICWTPLYV 219
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
6TO7_B      261 LNVLKrvfgMFRQASDREAV-YAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15206 220 INTWK----AFDPPSAARYVsSTTISLIQLLAYISSCVNPITYCFMNKRFRQAF 269
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
39-310 2.21e-50

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 169.23  E-value: 2.21e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15391  17 GNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTNTAIGI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTrafsVCDERW-ADDLAPKIYHSCFFI 197
Cdd:cd15391  97 DRFFAVIFPLRSRHTKSRTKCIIASIWAISFSLSSVQLFAGRTQRYGQYSEGRV----LCGESWpGPDTSRSAYTVFVML 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      198 VTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEV--KQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFR--Q 273
Cdd:cd15391 173 LTYIIPLLILTSTYGYVGFRLWNRTAPGNADKGRddMQIKSKRKVIKMLVFVVLMFGICWLPLHLFNLVQDFSTVFRnmP 252
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      274 ASDREAVYAAftfSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15391 253 QHTTRLIYGA---CHWIAMSNSFVNPIIYLFMNDSFR 286
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
39-310 5.69e-49

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 165.59  E-value: 5.69e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15389  17 GNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSVYVSTLTLTAIAL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAvmeCSSVLPELAARTRAFSVCDERWAD--DLAPKIYHSCFF 196
Cdd:cd15389  97 DRHRVILHPLKPRITPCQGVVVIAIIWIMASCLSLPHAI---YQKLVEFEYSNERTRSRCLPSFPEpsDLFWKYLDLATF 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKLWGRQIPG--TTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRvFGMFRQA 274
Cdd:cd15389 174 ILQYVLPLLIIGVAYTRVAKKLWLRNAIGdvTTEQYVAQRRKKKKTIKMLMLVVLLFAICWLPLNCYHVLLS-SHPIRSN 252
                       250       260       270
                ....*....|....*....|....*....|....*.
6TO7_B      275 SdreavyAAFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15389 253 S------ALFFAFHWLAMSSTCYNPFIYCWLNDSFR 282
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
39-313 7.54e-49

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 165.83  E-value: 7.54e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15980  17 GNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGISVSASVFTLVAIAV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSS-----VLPELAARTRAFSVCDERWADDLAPKIYHS 193
Cdd:cd15980  97 DRFRCIVYPFKQKLTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEeknyrVVLGSQNKTSPVYWCREDWPNQEMRKIYTT 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 CFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQM----RARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFG 269
Cdd:cd15980 177 VLFANIYLAPLSLIVIMYARIGITLFKTAMPHTGKHNQEQRhvvsRKKQKVIKMLLIVALLFILSWLPLWTLMMLSDYAN 256
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
6TO7_B      270 MFRQASDREAVYaAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15980 257 LSPNQLQIINIY-IYPFAHWLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
39-313 5.89e-48

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 163.46  E-value: 5.89e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15981  17 GNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQGMSVSASVFTLVAIAV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVM----ECSSVLPELAARTRAFSVCDERWADDLAPKIYHSC 194
Cdd:cd15981  97 ERFRCIVHPFRQKLTLRKAIVTIVIIWVLALIIMCPSAVTLtvtrEEHHFMVDDYNNSYPLYSCWEAWPDTEMRKIYTTV 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVTYLAPLGLMAMAYFQIFRKLWGRQIP--GTTSAEVKQMRARRKTAK---MLMVVVLVFALCYLPISVLNVLKRVFG 269
Cdd:cd15981 177 LFSHIYLAPLTLIVIMYARIAFKLFKSSAPirGSQGEEEEGRRVSKRKIKvinMLIIVALFFTLSWLPLWTLMLLTDYGH 256
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
6TO7_B      270 MFRQASDREAVYaAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15981 257 LSEDQLNLVTVY-VFPFAHWLAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
39-313 1.05e-46

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 158.88  E-value: 1.05e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd14967  16 GNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCCTASILNLCAISL 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAImvpqaavmecsSVLPELAARTRAFSVCDERWADDLAPKIYHSCFF 196
Cdd:cd14967  96 DRYLAITRPLRYRQlmTKKRALIMIAAVWVYSLLI-----------SLPPLVGWRDETQPSVVDCECEFTPNKIYVLVSS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRklwgrqipgttsaevkqmRARR--KTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQA 274
Cdd:cd14967 165 VISFFIPLLIMIVLYARIFR------------------VARRelKAAKTLAIIVGAFLLCWLPFFIIYLVSAFCPPDCVP 226
                       250       260       270
                ....*....|....*....|....*....|....*....
6TO7_B      275 sdreavYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd14967 227 ------PILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
39-313 2.25e-46

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 158.21  E-value: 2.25e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15001  16 GNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFICSVLTLTAISI 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVMEcssVLPELAARTRAFSVCDERWADDLAPKIYHSCFF 196
Cdd:cd15001  96 ERYYVILHPMKAKSfcTIGRARKVALLIWILSAILASPVLFGQG---LVRYESENGVTVYHCQKAWPSTLYSRLYVVYLA 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKlwgrqipgttsaevkqmrarrKTAKMLMVVVLVFALCYLPISVLNVLKRvFGMFrQASD 276
Cdd:cd15001 173 IVIFFIPLIVMTFAYARDTRK---------------------QVIKMLISVVVLFAVCWGPLLIDNLLVS-FDVI-STLH 229
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      277 REAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15001 230 TQALKYMRIAFHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
39-313 4.63e-46

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 158.41  E-value: 4.63e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15205  17 GNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQSTAVVTSILTMTCIAV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFK--STARRAlGSILGI-WAVSLAIMVPQAAVMECSSVLPELAARTRAFsvCDERWADDLAPKIYHSCF 195
Cdd:cd15205  97 ERHQGIVHPLKMKwqYTNRRA-FTMLGLvWIVSVIVGSPMLFVQQLEVKYDFLYEKRHVC--CLERWYSPTQQKIYTTFI 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEV--------KQMRARRKTAKMLMVVVLVFALCYLPISVLNVLkRV 267
Cdd:cd15205 174 LVILFLLPLTTMLFLYSRIGYELWIKKRVGDASVLQtihgiemsKISRKKKRAVKMMVTVVLLFAVCWAPFHVVHMM-IE 252
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
6TO7_B      268 FGMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15205 253 YSNLENKYDGVTIKLIFAIVQLIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
39-312 1.55e-43

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 151.43  E-value: 1.55e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITE-SWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15394  17 GNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPrGWVFGRFMCYFVFLMQPVTVYVSVFTLTAIA 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPqAAVMECSSVLPELaartrAFSVCDERWADDLAPKIYHSCFF- 196
Cdd:cd15394  97 VDRYYVTVYPLRRRISRRTCAYIVAAIWLLSCGLALP-AAAHTYYVEFKGL-----DFSICEEFWFGQEKQRLAYACSTl 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKLWGRQIPG--TTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFrqa 274
Cdd:cd15394 171 LITYVLPLLAISLSYLRISVKLRNRVVPGsmTQSQAEWDRARRRKTFRLLVVVVVAFAICWLPLHIFNVIRDIDIDL--- 247
                       250       260       270
                ....*....|....*....|....*....|....*...
6TO7_B      275 SDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQ 312
Cdd:cd15394 248 IDKQYFNLIQLLCHWLAMSSACYNPFLYAWLHDSFRGE 285
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
39-313 3.15e-43

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 150.88  E-value: 3.15e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15927  17 GNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCKLSEFLKDTSIGVSVFTLTALSA 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLL-FKSTA-RRALGSILGIWAVSLAIMVPQAAVmecSSVLPELAARTRAFSVC---DERWaDDLAPKIYHS 193
Cdd:cd15927  97 DRYFAIVNPMRkHRSQAtRRTLVTAASIWIVSILLAIPEAIF---SHVVTFTLTDNQTIQICypyPQEL-GPNYPKIMVL 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 CFFIVTYLAPLGLMAMAYFQIFRKLW--GRQIP-GTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPIsvlnvlkRVFGM 270
Cdd:cd15927 173 LRFLVYYLIPLLIIGVFYVLMARHLIrsTRNIGsGQNQAAQRQIEARKKVAKTVLAFVVLFAVCWLPR-------HVFML 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
6TO7_B      271 FRQASDREAV-YAAFTF-----SHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15927 246 WFHFAPNGLVdYNAFWHvlkivGFCLSFINSCVNPVALYLLSGSFRRHF 294
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
24-313 1.38e-40

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 143.81  E-value: 1.38e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       24 VLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQA 103
Cdd:cd15399   2 VLILAYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      104 VSVSVAVLTLSFIALDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTRAfsvCDERW- 182
Cdd:cd15399  82 LAVHVSTVTLTVIALDRHRCIVYHLESKISKKISFLIIGLTWAASALLASPLAIFREYSVIEISPDFKIQA---CSEKWp 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      183 -ADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQMraRRKTAKMLMVVVLVFALCYLPISVL 261
Cdd:cd15399 159 nGTLNDGTIYSVSMLLIQYVLPLAIISYAYIRIWTKLKNHVSPGGGNDHYHQR--RRKTTKMLVCVVVVFAVSWLPFHAF 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
6TO7_B      262 NVLKRVFGMFRQASDREAVYAAFtfsHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15399 237 QLASDIDSKVLDLKEYKLIYTIF---HVIAMCSTFANPLLYGWMNNNYRTAF 285
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
39-313 3.07e-40

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 142.56  E-value: 3.07e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNH--HMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 116
Cdd:cd15098  17 GNSLVITVLARVKpgKRRSTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKFVHYFFTVSMLVSIFTLVAM 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      117 ALDRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAavmecssVLPELAARTRA--FSVCDERWADDLAPKIYH 192
Cdd:cd15098  97 SVDRYIAVVHSRTSSSlrTRRNALLGVLVIWVLSLAMASPVA-------VHQDLVHHWTAsnQTFCWENWPEKQQKPVYV 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      193 SCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEvkqmRARRKTAKMLMVVVLVFALCYLPISVLNvLKRVFGMFR 272
Cdd:cd15098 170 VCTFVFGYLLPLLLITFCYAKVLNHLHKKLKNMSKKSE----RSKKKTAQTVLVVVVVFGISWLPHHIIH-LWVEFGDFP 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
6TO7_B      273 QASdreAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15098 245 LTQ---ASFVLRITAHCLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
39-313 5.93e-40

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 141.66  E-value: 5.93e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAIcLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd14970  17 GNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLG-LPFLATSYLLGYWPFGEVMCKIVLSVDAYNMFTSIFCLTVMSV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLlfKS----TARRALGSILGIWAVSLAIMVPqaaVMECSSVLPElaarTRAFSVCDERWADDlaPKIYH-- 192
Cdd:cd14970  96 DRYLAVVHPV--KSlrfrTPRKAKLVSLCVWALSLVLGLP---VIIFARTLQE----EGGTISCNLQWPDP--PDYWGrv 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      193 --SCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQmRARRKTAKMLMVVVLVFALCYLPISVLNVlkrVFGM 270
Cdd:cd14970 165 ftIYTFVLGFAVPLLVITVCYSLIIRRLRSSRNLSTSGAREKR-RARRKVTRLVLVVVAVFVVCWLPFHVFQI---VRLL 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
6TO7_B      271 FRQASDREAVYAAFTFSHwLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd14970 241 IDPPETLTVVGVFLFCIA-LSYANSCLNPILYAFLDENFRKSF 282
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
39-312 2.69e-39

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 140.64  E-value: 2.69e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15397  17 GNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQCMSVTVSILSLVLIAL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTRAFS----VCDERWADDLAPKIYHSC 194
Cdd:cd15397  97 ERHQLIINPTGWKPSVSQAYLAVVVIWMLACFISLPFLAFHILTDEPYKNLSHFFAPLadkaVCTESWPSEHHKLAYTTW 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVTYLAPLGLMAMAYFQIFRKLWGRQ-IPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLkrvfgmfrQ 273
Cdd:cd15397 177 LLLFQYCLPLLFILVCYLRIYLRLRRRKdMLERRGEYNRRAGHSKRINVMLVSLVAAFALCWLPLNVFNAI--------A 248
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
6TO7_B      274 ASDREAVYAA-----FTFSHWLVYANSAANPIIYNFLSGKFREQ 312
Cdd:cd15397 249 DWNHEAIPHCqhnliFSLCHLAAMASTCVNPIIYGFLNSNFKKE 292
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
39-313 1.19e-38

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 138.46  E-value: 1.19e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15978  17 GNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVSVSTFNLVAISL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFK--STARRALGSILGIWAVSLAIMVPQAAVmecSSVLPELAARTRAFSVCDERWADDLAPKIYHSCFF 196
Cdd:cd15978  97 ERYSAICKPLKSRvwQTKSHALKVIAATWCLSFTIMLPYPIY---SNLVPFTRINNSTGNMCRLLWPNDVTQQSWYIFLL 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKLWgrqipgttsAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLkRVFGmfRQASD 276
Cdd:cd15978 174 LILFLIPGIVMMTAYGLISLELY---------RGIKFLMAKKRVIRMLIVIVILFFLCWTPIFSANAW-RAFD--TRSAD 241
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      277 REAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15978 242 RLLSGAPISFIHLLSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-313 2.08e-38

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 137.75  E-value: 2.08e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd16003  17 GNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSVFASIYSMTAIAV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQaAVMECSSVLPelaARTRAFSVCDERWADDLapkIYHSCFFIV 198
Cdd:cd16003  97 DRYMAIIDPLKPRLSATATKVVIGSIWILAFLLAFPQ-CLYSKTKVMP---GRTLCFVAWPGGPDQHF---TYHIIVIVL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      199 TYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEV-KQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKrvfGMFRQASDR 277
Cdd:cd16003 170 VYCLPLLVMGITYTIVGITLWGGEIPGDTSDKYhEQLRAKRKVVKMMIIVVLTFAICWLPYHIYFIVT---GLYQQLNRW 246
                       250       260       270
                ....*....|....*....|....*....|....*.
6TO7_B      278 EAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd16003 247 KYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
39-313 6.99e-37

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 133.25  E-value: 6.99e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15067  16 GNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGyWLFGRDWCDVWHSFDVLASTASILNLCVIS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAartrafSVCdeRWADDLAPKIYHSCf 195
Cdd:cd15067  96 LDRYWAITDPISYPSrmTKRRALIMIALVWICSALISFPAIAWWRAVDPGPSPP------NQC--LFTDDSGYLIFSSC- 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 fiVTYLAPLGLMAMAYFQIFRklwgrqipgttsAEVKQmrarRKTAKMLMVVVLVFALCYLPISVLNVLKrVFGMFRQAS 275
Cdd:cd15067 167 --VSFYIPLVVMLFTYYRIYR------------AAAKE----QKAAKTLGIVMGVFILCWLPFFVTNILI-GFCPSNCVS 227
                       250       260       270
                ....*....|....*....|....*....|....*...
6TO7_B      276 DREAVYAAFTfshWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15067 228 NPDILFPLVT---WLGYINSGMNPIIYACSSRDFRRAF 262
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
39-257 2.44e-36

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 132.40  E-value: 2.44e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASL--LVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 116
Cdd:cd15204  17 GNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMdyYVVRQRSWTHGDVLCAVVNYLRTVSLYVSTNALLVI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      117 ALDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAvmecSSVLPELAARTRAFsvCDERWADDLAP--KIYHSC 194
Cdd:cd15204  97 AIDRYLVIVHPLKPRMKRRTACVVIALVWVVSLLLAIPSAV----YSKTTPYANQGKIF--CGQIWPVDQQAyyKAYYLF 170
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
6TO7_B      195 FFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQMRA-RRKTAKMLMVVVLVFALCYLP 257
Cdd:cd15204 171 LFVLEFVLPVLIMTLCYLRIVRKVWFRRVPGQQTEQIRRRLRrRRRKVRLLVVILTAFVLCWAP 234
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
23-313 7.38e-36

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 131.09  E-value: 7.38e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       23 WVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQ 102
Cdd:cd15979   1 TVRILLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      103 AVSVSVAVLTLSFIALDRWYAICHPLLFK--STARRALGSILGIWAVSLAIMVPQAAVmecSSVLPELAARTRAFSVCDE 180
Cdd:cd15979  81 GVSVSVSTFSLVAIAIERYSAICNPLQSRvwQTRSHAYRVIAATWLLSGLIMIPYPVY---SVTVPVPVGDRPRGHQCRH 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      181 RWADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsaevKQMRARRKTAKMLMVVVLVFALCYLPISV 260
Cdd:cd15979 158 AWPSAQVRQAWYVLLLLILFFIPGVVMIVAYGLISRELY------------RGLLAKKRVIRMLVVIVAMFFLCWLPIFS 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
6TO7_B      261 LNVLKrvfgMFRQASDREAVYAA-FTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15979 226 ANTWR----AFDPLSAHRALSGApISFIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-313 1.17e-35

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 130.84  E-value: 1.17e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15125  17 GNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQLTSVGVSVFTLTALSA 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTAR--RALGSILGIWAVSLAIMVPQAAVMECSSVLPElaaRTRAFSVC-DERWADDLAPKIYHSCF 195
Cdd:cd15125  97 DRYKAIVNPMDIQTSSAvlRTCLKAIAIWVVSVLLAVPEAVFSEVAHIMPD---DNTTFTACiPYPQTDEMHPKIHSVLI 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKLW--GRQIPGTTSAEVK-QMRARRKTAKMLMVVVLVFALCYLPISVLnVLKRVFGmFR 272
Cdd:cd15125 174 FLVYFLIPLAIISIYYYHIAKTLIksAHNIPGEYSEHSKrQMETRKRLAKIVLVFVGLFAFCWFPNHVL-YMYRSFN-YN 251
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
6TO7_B      273 QASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15125 252 EIDSSLGHMIVTLVARVLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
23-313 3.06e-33

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 123.65  E-value: 3.06e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       23 WVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVlataICLPASLLVDITES------WLFGHALCK 96
Cdd:cd14995   1 VVATFLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADL----MVLVAAGLPNEIESllgpdsWIYGYAGCL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       97 VIPYLQAVSVSVAVLTLSFIALDRWYAICHPL--LFKSTARRALGSILGIWAVSLAIMVPQAAVMEcssvLPELAARTRA 174
Cdd:cd14995  77 LITYLQYLGINASSLSITAFTIERYIAICHPMkaQFICTVSRAKKIICFVWIFTSLYCSPWLFLLD----LSIKHYGDDI 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      175 FSVCDERWADDLAPKIYHSCFFIVtYLAPLGLMAMAYFQIFRKLWgrqipgttsaevkqmRARRKTAKMLMVVVLVFALC 254
Cdd:cd14995 153 VVRCGYKVSRHYYLPIYLADFVLF-YVIPLLLAIVLYGLIGRILF---------------SSRKQVTKMLAVVVVLFALL 216
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
6TO7_B      255 YLPISVLnvlkRVFGMFRQASDREAVYaaFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd14995 217 WMPYRTL----VVYNSFASPPYLDLWF--LLFCRTCIYLNSAINPILYNLMSQKFRAAF 269
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-313 3.39e-33

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 124.19  E-value: 3.39e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd16004  17 GNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFVSIYSMTAIAA 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPElaartrafSVCDERWADDLAPK---IYHSCF 195
Cdd:cd16004  97 DRYMAIIHPFKPRLSAGSTKVVIAGIWLVALALAFPQCFYSTVTMDQGR--------TKCIVAWPGDSGGKhqlTYHLAV 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKLWGRQIPG--TTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQ 273
Cdd:cd16004 169 IVLIYLLPLAVMFVTYSIIGITLWRSAVPGhqAHGAYHRQLQAKKKFVKTMVVVVVTFAICWLPYHLYFILGSFNEDIYC 248
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
6TO7_B      274 ASDREAVYAAFtfsHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd16004 249 QKYIQQVYLAI---FWLAMSSTMYNPIIYCCLNQRFRSGF 285
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
39-313 7.84e-33

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 123.62  E-value: 7.84e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDI-TESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd14979  17 GNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWwQYPWAFGDGGCKLYYFLFEACTYATVLTIVALS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTRAFSVCDERWADDLAPKIYHSCF 195
Cdd:cd14979  97 VERYVAICHPLKAKTlvTKRRVKRFILAIWLVSILCAIPILFLMGIQYLNGPLPGPVPDSAVCTLVVDRSTFKYVFQVST 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIvTYLAPLGLMAMAYFQIFRKLW-------GRQIPGTTSAEVKQM-RARRKTAKMLMVVVLVFALCYLPISVLNVLKRV 267
Cdd:cd14979 177 FI-FFVLPMFVISILYFRIGVKLRsmrnikkGTRAQGTRNVELSLSqQARRQVVKMLGAVVIAFFVCWLPFHAQRLMFSY 255
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
6TO7_B      268 FGMFrQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd14979 256 ASKE-DTFLFDFYQYLYPISGILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
39-311 7.93e-33

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 123.40  E-value: 7.93e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15396  17 GNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDHWIFGETMCKLTSFVQSVSVSVSIFSLVLIAI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECS-SVLPELAARTRAFS---VCDERWADDLAPKIYHSC 194
Cdd:cd15396  97 ERYQLIVNPRGWKPSASHAYWGIVLIWLFSLMISIPFLIFHQLTdEPFRNLSSHSDFYKdkvVCIEAWPSETERLIFTTS 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVTYLAPLGLMAMAYFQIFRKLWGRqipgttSAEVKQMRAR-------RKTAKMLMVVVLVFALCYLPISVLNVlkrV 267
Cdd:cd15396 177 LLVFQYFVPLGFIFICYLKIFVCLKKR------NSKIDRMRENesrlsenKRINTMLISIVVTFAACWLPLNIFNV---V 247
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
6TO7_B      268 FGMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15396 248 FDWNHEVLMSCHHNLVFTLCHLVAMVSTCINPIFYGFLNKNFQK 291
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
39-313 1.12e-32

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 123.11  E-value: 1.12e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15123  17 GNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQLTSVGVSVFTLTVLSA 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKST--ARRALGSILGIWAVSLAIMVPQAAVMECSSVL-PElaaRTRAFSVCDERWADDLAPKIYHSCF 195
Cdd:cd15123  97 DRYRAIVKPLELQTSdaVLKTCCKAGCVWIVSMLFAIPEAVFSDLYSFRdPE---KNTTFEACAPYPVSEKILQEIHSLL 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 -FIVTYLAPLGLMAMAYFQIFRKLWGR--QIPGTTSAEV-KQMRARRKTAKMLMVVVLVFALCYLPISVLnVLKRVFgMF 271
Cdd:cd15123 174 cFLVFYIIPLSIISVYYFLIARTLYKStfNMPAEEHSHArKQIESRKRVAKTVLVLVALFAFCWLPNHIL-YLYRSF-TY 251
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
6TO7_B      272 RQASDREAVYAAFT-FSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15123 252 HTSVDSSAFHLIATiFSRVLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
39-313 2.18e-32

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 121.98  E-value: 2.18e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFgHAlCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd14968  17 GNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLGLPTNF-HG-CLFMACLVLVLTQSSIFSLLAIAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAI-MVPqaaVMECSSVLPELAARTRAFSVCDERWADDLAPKIYHScf 195
Cdd:cd14968  95 DRYLAIKIPLRYKSlvTGRRAWGAIAVCWVLSFLVgLTP---MFGWNNGAPLESGCGEGGIQCLFEEVIPMDYMVYFN-- 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKLWG--RQIPGTTSAEVKQ--MRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMF 271
Cdd:cd14968 170 FFACVLVPLLIMLVIYLRIFRVIRKqlRQIESLLRSRRSRstLQKEVKAAKSLAIILFLFALCWLPLHIINCITLFCPEC 249
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
6TO7_B      272 RqaSDREAVYAAFTFSHwlvyANSAANPIIYNFLSGKFREQF 313
Cdd:cd14968 250 K--VPKILTYIAILLSH----ANSAVNPIVYAYRIRKFRQTF 285
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
39-313 2.33e-32

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 122.15  E-value: 2.33e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd14977  17 GNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQVTSLGVTVFSLCALSI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTA--RRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTRAFSVCDERWADDLAPKIYHSCFF 196
Cdd:cd14977  97 DRYRAAVNSMPMQTIGacLSTCVKLAVIWVGSVLLAVPEAVLSTVARESSLDNSSLTVCIMKPSTPFAETYPKARSWWLF 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKLwGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASD 276
Cdd:cd14977 177 GCYFCLPLAFTAVCYLLMARTL-IRAAKEYTRGTKKHMKQRRQLAKTVLCLVLVFAFCWLPEHISNILRATLYNEVLIDT 255
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      277 REAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd14977 256 RSTLDILDLIGQFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
39-310 3.40e-32

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 121.44  E-value: 3.40e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLaTAICLPASLL-VDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15928  17 GNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLL-IFLVLPLDLYrLWRYRPWRFGDLLCRLMYFFSETCTYASILHITALS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTRAFSVCDERWADDLAPKIYHSCF 195
Cdd:cd15928  96 VERYLAICHPLRAKVlvTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPRGFECTVVNVSSGLLSVMLWVSTSF 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVtylaPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVlnvlKRVFGMFRQAS 275
Cdd:cd15928 176 FFV----PMVCLSLLYGLIGRALWDRRQRSRTAGASRRDNNHRQTVRMLAVIVLAFVLCWLPFHV----GRVIFNHSRAS 247
                       250       260       270
                ....*....|....*....|....*....|....*...
6TO7_B      276 DREAVYAAFTF---SHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15928 248 TKHLHYVSQYFnlvSFVLFYLSAAINPILYNLMSKRYR 285
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
39-310 3.40e-32

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 121.85  E-value: 3.40e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15395  17 GNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFGEAMCKLNSMVQCISITVSIFSLVLIAI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVP----QAAVMECSSVLPELAARTRAFSVCDERWADDLAPKIYHSC 194
Cdd:cd15395  97 ERHQLIINPRGWRPNNRHAYVGIAVIWVLAVLTSLPflifQVLTDEPFKNVNVSLDAYKGKYVCLDQFPSDTIRLSYTTC 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVTYLAPLGLMAMAYFQIFRKLWGRQipgTTSAEVKQMRARRKTAK----MLMVVVLVFALCYLPISVLNVlkrVFGM 270
Cdd:cd15395 177 LLVLQYFGPLCFIFICYLKIYIRLKRRN---NMMDKMRDNKYRSSETKriniMLISIVVAFAVCWLPLNIFNA---VFDW 250
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
6TO7_B      271 FRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15395 251 NHEAIATCNHNLLFLICHLTAMISTCVNPIFYGFLNKNFQ 290
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
39-313 4.43e-32

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 121.16  E-value: 4.43e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd14969  17 LNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSISTLAALAF 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLL-FKSTARRALGSILGIWAVSLAIMVPqaAVMECSSVLPELaartrAFSVCDERWAD-DLAPKIYHSCFF 196
Cdd:cd14969  97 ERYLVIVRPLKaFRLSKRRALILIAFIWLYGLFWALP--PLFGWSSYVPEG-----GGTSCSVDWYSkDPNSLSYIVSLF 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQ----MRARRKTAKMLMVVVLVFALCYLPISVLNVLkRVFGMFR 272
Cdd:cd14969 170 VFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAItkrtKKAEKKVAKMVLVMIVAFLIAWTPYAVVSLY-VSFGGES 248
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
6TO7_B      273 QASDREAVYAAFtfshwlvYANSAA--NPIIYNFLSGKFREQF 313
Cdd:cd14969 249 TIPPLLATIPAL-------FAKSSTiyNPIIYVFMNKQFRRAL 284
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-308 4.82e-32

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 121.38  E-value: 4.82e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15197  17 GNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVEWRAGDFACKVIRYLQVVVTYASTYVLVALSI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPqaavmecSSVLPELAARTRAFSVCDERWADDLAPKIYHSCFFIV 198
Cdd:cd15197  97 DRYDAICHPMNFSQSGRQARVLICVAWILSALFSIP-------MLIIFEKTGLSNGEVQCWILWPEPWYWKVYMTIVAFL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      199 TYLAPLGLMAMAYFQIFRKLW------------GRQIPGTTSAEVKQM--RARRKTAKMLMVVVLVFALCYLPISVLNVL 264
Cdd:cd15197 170 VFFIPATIISICYIIIVRTIWkkskiqvtinkaGLHDGSSRRSSSRGIipRAKIKTIKMTFVIVTVFIICWSPYFVFDLL 249
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
6TO7_B      265 KrvfgMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGK 308
Cdd:cd15197 250 D----VFGLLPRSKTKIAAATFIQSLAPLNSAINPLIYCLFSTH 289
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
39-313 5.10e-32

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 121.33  E-value: 5.10e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd14986  17 GNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGLFASTYILVSMSL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMecssVLPELAartRAFSVCDERWADDLAPKIYHSCFFIV 198
Cdd:cd14986  97 DRYQAIVKPMSSLKPRKRARLMIVVAWVLSFLFSIPQLVIF----VERELG---DGVHQCWSSFYTPWQRKVYITWLATY 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      199 TYLAPLGLMAMAYFQIFRKLW-----------------GRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVL 261
Cdd:cd14986 170 VFVIPLIILSYCYGRILRTIWirsrqktdrpiaptamsCRSVSCVSSRVSLISRAKIKTIKMTLVIILAFILCWTPYFIV 249
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
6TO7_B      262 NvLKRVFGMFRQASDREAVYAAFTFShwlvyANSAANPIIYNFLSGKFREQF 313
Cdd:cd14986 250 Q-LLDVYAGMQQLENDAYVVSETLAS-----LNSALNPLIYGFFSSHLSFEH 295
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-313 6.96e-32

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 120.74  E-value: 6.96e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd16002  17 GNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAAVFASIYSMTAIAL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVmecsSVLPELAARTrafsVCDERWAD---DLAPKIYHSCF 195
Cdd:cd16002  97 DRYMAIIHPLQPRLSATATKVVICVIWVLAFLLAFPQGYY----SDTEEMPGRV----VCYVEWPEheeRKYETVYHVCV 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEV-KQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQA 274
Cdd:cd16002 169 TVLIYFLPLLVIGCAYTVVGITLWASEIPGDSSDRYhEQVSAKRKVVKMMIVVVCTFAICWLPYHIYFLLQYFHPELYEQ 248
                       250       260       270
                ....*....|....*....|....*....|....*....
6TO7_B      275 SDREAVYAAFTfshWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd16002 249 KFIQQVYLAIM---WLAMSSTMYNPIIYCCLNDRFRVGF 284
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
39-313 1.22e-31

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 120.13  E-value: 1.22e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITE-SWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15134  17 GNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQyPWVFGEVFCKLRAFLSEMSSYASVLTITAFS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFK--STARRALGSILGIWAVSLAIMVPQAAVMECSSV-LPELAARTRAFS-VCD-ERWADDLAPKIYH 192
Cdd:cd15134  97 VERYLAICHPLRSHtmSKLSRAIRIIIAIWIIAFVCALPFAIQTRIVYLeYPPTSGEALEESaFCAmLNEIPPITPVFQL 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      193 SC--FFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKrVFGM 270
Cdd:cd15134 177 STflFFIIPMIAIIVLYVLIGLQLRRSTLLRRGQRSVSGGRRSSQSRRTVLRMLVAVVVAFFICWAPFHAQRLLT-VYAK 255
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
6TO7_B      271 FRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15134 256 NMTPPYLFINRILFYISGVLYYVSSTVNPILYNVMSAKYRQAF 298
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
39-313 1.49e-31

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 119.49  E-value: 1.49e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15093  17 GNSLVIYVVLRYAKMKTVTNIYILNLAIADELFM-LGLPFLAASNALRHWPFGSVLCRLVLSVDGINMFTSIFCLTVMSV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLlfKST----ARRALGSILGIWAVSLAIMVPQAavmecssVLPELAARTRAFSVCDERWADDLApkIYHSC 194
Cdd:cd15093  96 DRYLAVVHPI--KSArwrrPRVAKVVNLAVWVASLLVILPVV-------VFAGTRENQDGSSACNMQWPEPAA--AWSAG 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVT----YLAPLGLMAMAYFQIFRKLwgrQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKrvfgM 270
Cdd:cd15093 165 FIIYTfvlgFLLPLLIICLCYLLIVIKV---KSAGLRAGWQQRKRSERKVTRMVVMVVVVFVICWLPFYVLQLVN----V 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
6TO7_B      271 FRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15093 238 FVQLPETPALVGVYHFVVILSYANSCANPILYGFLSDNFKKSF 280
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
39-313 3.75e-31

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 118.22  E-value: 3.75e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15053  17 GNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGGkWYLGPILCDIYIAMDVMCSTASIFNLCAIS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPQAAVMEcssvlpelAARTRAFSVCDERWADDLapkIYHScf 195
Cdd:cd15053  97 IDRYIAVTQPIKYarQKNSKRVLLTIAIVWVVSAAIACPLLFGLN--------NVPYRDPEECRFYNPDFI---IYSS-- 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 fIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsaevkqmRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVfGMFRQAS 275
Cdd:cd15053 164 -ISSFYIPCIVMLLLYYRIFRAL----------------RREKKATKTLAIVLGVFLFCWLPFFTLNILNAI-CPKLQNQ 225
                       250       260       270
                ....*....|....*....|....*....|....*...
6TO7_B      276 DREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15053 226 SCHVGPALFSLTTWLGYVNSFLNPIIYTIFNIEFRKAF 263
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
39-313 6.17e-31

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 118.00  E-value: 6.17e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHM-RTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15097  17 GNSLVLAVLLRSGQSgHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLTMYASSFTLAAVS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVMECSsvlpelaaRTRAFSVCDERWaDDLAPKIYHSCF 195
Cdd:cd15097  97 VDRYLAIRYPLRSRElrTPRNAVAAIALIWGLSLLFAGPYLSYYDLI--------DYANSTVCMPGW-EEARRKAMDTCT 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKqmRARRKTAKMLMVVVLVFALCYLPISVLnVLKRVFGMFrqaS 275
Cdd:cd15097 168 FAFGYLIPVLVVSLSYTRTIKYLWTAVDPLEAMSESK--RAKRKVTKMIIIVTALFCLCWLPHHVV-ILCYLYGDF---P 241
                       250       260       270
                ....*....|....*....|....*....|....*...
6TO7_B      276 DREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15097 242 FNQATYAFRLLSHCMAYANSCLNPIVYALVSKHFRKGF 279
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
39-313 9.83e-31

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 117.43  E-value: 9.83e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15051  17 GNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDVMLCTASILNLFAISL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAImvpqaavmecsSVLP-ELAARTRAFSVCDERWADDL---APKIYH 192
Cdd:cd15051  97 DRYLAITAPLRYPSrvTPRRVAIALAAIWVVSLAV-----------SFLPiHLGWNTPDGRVQNGDTPNQCrfeLNPPYV 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      193 SCFFIVTYLAPLGLMAMAYFQIFR--KLWGRQIPGTT-----SAEVKQMRAR-RKTAKMLMVVVLVFALCYLPISVLNVL 264
Cdd:cd15051 166 LLVAIGTFYLPLLIMCGVYLRIFRiaREQAKRINALTpastaNSSKSAATAReHKATVTLAAVLGAFIICWFPYFTYFTY 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
6TO7_B      265 KRvfgmFRQASDREAVYAAFTfshWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15051 246 RG----LCGDNINETALSVVL---WLGYANSALNPILYAFLNRDFRRAF 287
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
39-311 3.40e-30

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 116.00  E-value: 3.40e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15012  16 GNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYTASIGILVVISV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVMECSSVLpeLAARTRAFSVCDERWADDLApKIYHSCFF 196
Cdd:cd15012  96 ERYIAILHPLRCKQllTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEIL--VTQDGQEEEICVLDREMFNS-KLYDTINF 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKLWGRQipgttsaevkQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASD 276
Cdd:cd15012 173 IVWYLIPLLIMTVLYSKISIVLWKSS----------SIEARRKVVRLLVAVVVSFALCNLPYHARKMWQYWSEPYRCDSN 242
                       250       260       270
                ....*....|....*....|....*....|....*
6TO7_B      277 REAVYAAFTFshWLVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15012 243 WNALLTPLTF--LVLYFNSAVNPLLYAFLSKRFRQ 275
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
38-313 7.19e-30

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 115.05  E-value: 7.19e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       38 VGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATaICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFI 116
Cdd:cd14982  16 LGNILALWVFLRKMKKRSPTTIYMINLALADLLFV-LTLPFRIYYYLNGGwWPFGDFLCRLTGLLFYINMYGSILFLTCI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      117 ALDRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPqaavmecSSVLPELAARTRAFSVCDERWADDLAPKIYHSC 194
Cdd:cd14982  95 SVDRYLAVVHPLKSRRlrRKRYAVGVCAGVWILVLVASVP-------LLLLRSTIAKENNSTTCFEFLSEWLASAAPIVL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVT-YLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEvkqmraRRKTAKMLMVVVLVFALCYLPisvLNVLKRVFGMFRQ 273
Cdd:cd14982 168 IALVVgFLIPLLIILVCYSLIIRALRRRSKQSQKSVR------KRKALRMILIVLAVFLVCFLP---YHVTRILYLLVRL 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
6TO7_B      274 A-----SDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd14982 239 SfiadcSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
53-313 7.20e-30

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 115.38  E-value: 7.20e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       53 MRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPL---- 128
Cdd:cd15124  31 MRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMdiqa 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      129 ---LFKSTARRALgsilgIWAVSLAIMVPQAAVMECSSVLPELAARTraFSVCDER-WADDLAPKIYHSCFFIVTYLAPL 204
Cdd:cd15124 111 snaLMKICLKAAL-----IWILSMLLAIPEAVFSDLHPFYDKSTNKT--FVSCAPYpHSNELHPKIHSMASFLIFYVIPL 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      205 GLMAMAYFQIFRKLW--GRQIPGTTSAEV-KQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFgmFRQASDREAVY 281
Cdd:cd15124 184 SIISVYYYFIAKNLIrsAYNLPVEGNVHVrRQIESRKRLAKTVLVFVGLFAFCWLPNHIIYLYRSYH--YSEVDTSMLHF 261
                       250       260       270
                ....*....|....*....|....*....|..
6TO7_B      282 AAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15124 262 VSSICARILAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
39-313 8.82e-30

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 114.38  E-value: 8.82e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15061  16 GNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDVLLCTASILNLCCISL 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPqaavmecssvlPELAARTRAFSVCDE-RWADDLAPKIYHScf 195
Cdd:cd15061  96 DRYFAITYPLKYrtKRSRRLAITMILAVWVISLLITSP-----------PLVGPSWHGRRGLGScYYTYDKGYRIYSS-- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 fIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsaevkqmRARRKTAKMLMVVVLVFALCYLPISVLNVLKrvfgMFRQAS 275
Cdd:cd15061 163 -MGSFFLPLLLMLFVYLRIFRVI----------------AKERKTAKTLAIVVGCFIVCWLPFFIMYLIE----PFCDCQ 221
                       250       260       270
                ....*....|....*....|....*....|....*...
6TO7_B      276 DREAVYAAFTfshWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15061 222 FSEALSTAFT---WLGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
39-317 1.64e-28

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 110.88  E-value: 1.64e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15064  17 GNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDVTCCTASILHLCVIAL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPqaavmecssvlPELAARTRAFSVCDE-RWADDLAPKIYHSC- 194
Cdd:cd15064  97 DRYWAITDAVEYahKRTPKRAAVMIALVWTLSICISLP-----------PLFGWRTPDSEDPSEcLISQDIGYTIFSTFg 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 -FFIvtylaPLGLMAMAYFQIFRklwgrqipgTTSAEvkqmrarRKTAKMLMVVVLVFALCYLPISVLNVlkrVFGMFRQ 273
Cdd:cd15064 166 aFYI-----PLLLMLILYWKIYR---------AAARE-------RKAAKTLGIILGAFIVCWLPFFLVAL---IVPLCSH 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
6TO7_B      274 ASDREAVYAAFTfshWLVYANSAANPIIYNFlsgkFREQFKAAF 317
Cdd:cd15064 222 CWIPLALKSFFL---WLGYFNSLINPLIYTF----FNKDFRKAF 258
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
39-313 1.97e-28

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 110.87  E-value: 1.97e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15052  17 GNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFGGvWPLPLVLCLLWVTLDVLFCTASIMHLCTIS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQA--AVMECSSVLPEL--AARTRAFsvcderwaddlapKIY 191
Cdd:cd15052  97 LDRYMAIRYPLRTRRnkSRTTVFLKIAIVWLISIGISSPIPvlGIIDTTNVLNNGtcVLFNPNF-------------VIY 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      192 HScffIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsaevkqmRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMF 271
Cdd:cd15052 164 GS---IVAFFIPLLIMVVTYALTIRLL----------------SNEQKASKVLGIVFAVFVICWCPFFITNILTGLCEEC 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
6TO7_B      272 RQASDrEAVYAAFTfshWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15052 225 NCRIS-PWLLSVFV---WLGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
39-313 7.62e-28

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 110.21  E-value: 7.62e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMR-TVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGhALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15057  17 GNALVIAAVLRFRHLRsKVTNYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFG-SFCDVWVSFDIMCSTASILNLCVIS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKS--TARRALGSILGIWAVSLAImvpqaavmecsSVLPELAARTRAFSVCDERWADDLAP------- 188
Cdd:cd15057  96 VDRYWAISSPFRYERrmTRRRAFIMIAVAWTLSALI-----------SFIPVQLGWHRADDTSEALALYADPCqcdssln 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      189 KIYHSCFFIVTYLAPLGLMAMAYFQIFR------------KLWGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYL 256
Cdd:cd15057 165 RTYAISSSLISFYIPVAIMIVTYTRIYRiarrqirriaalERAAQESTNPDSSLRSSLRRETKALKTLSIIMGVFVCCWL 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
6TO7_B      257 PISVLNVLKRvFGMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFlSGKFREQF 313
Cdd:cd15057 245 PFFILNCVLP-FCDLRTAQFPCVPDTTFIVFVWLGWANSSLNPIIYAF-NADFRKAF 299
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
39-313 1.41e-27

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 108.88  E-value: 1.41e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAIcLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15089  17 GNVLVMYGIVRYTKMKTATNIYIFNLALADALATST-LPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHP---LLFKSTARRALGSILgIWAVSLAIMVPqAAVMECSSVlPELAARTRAFSVCDERWADDLAPKIyhsCF 195
Cdd:cd15089  96 DRYIAVCHPvkaLDFRTPAKAKLINIC-IWVLSSGVGVP-IMVMAVTKT-PRDGAVVCMLQFPSPSWYWDTVTKI---CV 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAY-FQIFRKLWGRQIPGTTSAEvkqmRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQa 274
Cdd:cd15089 170 FIFAFVVPILVITVCYgLMILRLRSVRLLSGSKEKD----RNLRRITRMVLVVVAAFIICWTPIHIFVIVWTLVDIDRR- 244
                       250       260       270
                ....*....|....*....|....*....|....*....
6TO7_B      275 sdREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15089 245 --NPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 281
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
39-310 1.42e-27

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 108.48  E-value: 1.42e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADvLATAIC--LPaSLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 116
Cdd:cd15196  17 GNSCVLLVLYRRRRKLSRMHLFILHLSVAD-LLVALFnvLP-QLIWDITYRFYGGDLLCRLVKYLQVVGMYASSYVLVAT 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      117 ALDRWYAICHPLL-FKSTARRALGSILGIWAVSLAIMVPQAAVMEcssvLPELAARTRAfsvCDERWADDLAPKIYHSCF 195
Cdd:cd15196  95 AIDRYIAICHPLSsHRWTSRRVHLMVAIAWVLSLLLSIPQLFIFS----YQEVGSGVYD---CWATFEPPWGLRAYITWF 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsaevkqmRARRKTAKMLMVVVLVFALCYLPISVLNVLkrvfgmfrQAS 275
Cdd:cd15196 168 TVAVFVVPLIILAFCYGRICYVVW---------------RAKIKTVKLTLVVVACYIVCWTPFFVVQMW--------AAW 224
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      276 DREAVY--AAFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15196 225 DPTAPIegPAFVIIMLLASLNSCTNPWIYLAFSGNLR 261
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
39-311 4.02e-27

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 107.45  E-value: 4.02e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15213  17 GNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYWFFVLEGVAILLIISV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPlLFKSTARRALGSILGIWAVSLAIMVPQAAVMecssvlPELAARTRAFSvCDERWADDLAPKIYHSCFFIV 198
Cdd:cd15213  97 DRYLIIVQR-QDKLNPHRAKILIAVSWVLSFCVSFPPLVGW------GKYEFPPRAPQ-CVLGYTESPADRIYVVLLLVA 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      199 TYLAPLGLMAMAYFQIFRKlwgrqipgttsaeVKQMRARRKTAkmLMVVVLVFALCYLPISVLNVLkrvfGMFRQASDre 278
Cdd:cd15213 169 VFFIPFLIMLYSYFCILNT-------------VRSFKTRAFTT--ILILFIGFSVCWLPYTVYSLL----SVFSRYSS-- 227
                       250       260       270
                ....*....|....*....|....*....|...
6TO7_B      279 AVYAAFTFSHWLVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15213 228 SFYVISTCLLWLSYLKSAFNPVIYCWRIKKFRE 260
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
39-313 4.03e-27

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 107.95  E-value: 4.03e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15094  17 GNGLVIYVVLRYAKMKTVTNLYILNLAVADECFL-IGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQFTSSFTLTVMSA 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPqaaVMECSSVLPELAARTrafsvCDERWADDLA---PKIYHS 193
Cdd:cd15094  96 DRYLAVCHPIRSMRyrTPFIAKVVCATTWSISFLVMLP---IILYASTVPDSGRYS-----CTIVWPDSSAvngQKAFTL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 CFFIVTYLAPLGLMAMAYFQIFRKLwGRQIPGTTSAEVKqmRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQ 273
Cdd:cd15094 168 YTFLLGFAIPLLLISVFYTLVILRL-RTVGPKNKSKEKR--RSHRKVTRLVLTVISVYIICWLPYWAFQVHLIFLPPGTD 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
6TO7_B      274 ASDREAvyAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15094 245 MPKWEI--LMFLLLTVLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
39-317 8.31e-27

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 106.87  E-value: 8.31e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAIcLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15092  17 GNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLT-LPFQGTDIFLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPL--LFKSTARRALGSILGIWAVSLAIMVPqAAVM----------ECSSVLPElaartrafsvcderwADDL 186
Cdd:cd15092  96 DRYVAICHPIkaLDVRTPHKAKVVNVCIWALASVVGVP-VMVMgsaqvedeeiECLVEIPT---------------PQDY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      187 APKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIpgtTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLnVLKR 266
Cdd:cd15092 160 WDPVFGICVFLFSFIIPVLIISVCYSLMIRRLRGVRL---LSGSKEKDRNLRRITRLVLVVVAVFVGCWTPIQIF-VLAQ 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
6TO7_B      267 VFGmFRQASDREAVYAAFTFShwLVYANSAANPIIYNFLSgkfrEQFKAAF 317
Cdd:cd15092 236 GLG-VQPSSETAVAILRFCTA--LGYVNSSLNPVLYAFLD----ENFKACF 279
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
39-313 1.06e-26

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 106.87  E-value: 1.06e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPasllVDITESW-----LFGHALCKVIPYLQAVSVSVAVLTL 113
Cdd:cd15357  17 GNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMP----LEVYEMWsnypfLFGPVGCYFKTALFETVCFASILSV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      114 SFIALDRWYAICHPLLFK--STARRALGSILGIWAVSLAIMVPQAAV-------MECSSVLPELAARTrafsVCDERWAD 184
Cdd:cd15357  93 TTVSVERYVAILHPFRAKlnSTRERALKIIVVLWVLSVLFSIPNTSIhgiklqyFPNGTLIPDSATCT----VVKPLWIY 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      185 DLAPKIYHSCFfivtYLAPLGLMAMAYFqifrkLWGRQIPGTTSAEVKQMRA------RRKTAKMLMVVVLVFALCYLPI 258
Cdd:cd15357 169 NLIIQITSLLF----YVLPMGVISVLYY-----LMGLKLRGDKSLEADEMNVniqrpsRKSVTKMLFVLVLVFAICWAPF 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
6TO7_B      259 SVlnvlKRVFGMFRQASDrEAVYAAFTFSH----WLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15357 240 HV----DRLFFSFVVEWT-EPLANVFNLIHvvsgVFFYLSSAVNPIIYNLLSRRFRTAF 293
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
39-304 1.10e-26

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 106.78  E-value: 1.10e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDIT-ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15212  17 GNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSrPGWLFGDRLCLANGFFNACFGIVSTLTMTLIS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPqaavMECSSVLPELAARtRAFSVCDERWADDLAP--KIYHSCF 195
Cdd:cd15212  97 FDRYYAIVRQPQGKIGRRRALQLLAAAWLTALGFSLP----WYLLASAPEYYEK-LGFYHCLYVLHSGPSRlgAAYSSVL 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKLWGRQI---PGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGM-F 271
Cdd:cd15212 172 IVLCYLLPFALMCFCHYNICKTVRLSESrvrPVTTYAHLLRFYSEMRTATTVLIMIVFIICCWGPYCLLGLVAAAGGYqF 251
                       250       260       270
                ....*....|....*....|....*....|...
6TO7_B      272 RQASDREAVyaaftfshWLVYANSAANPIIYNF 304
Cdd:cd15212 252 PPLMDTVAI--------WMAWANGAINPLIYAI 276
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
39-313 1.17e-26

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 106.42  E-value: 1.17e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15974  17 GNTLVIYVVLRYAKMKTVTNIYILNLAVADELFM-LGLPFLATQNAISYWPFGSFLCRLVMTVDGVNQFTSIFCLTVMSI 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILG--IWAVSLAIMVPqaaVMECSSVLPElaartraFSVCDERWADDLApkIYHSCFF 196
Cdd:cd15974  96 DRYLAVVHPIKSTKWRRPRVAKLINatVWTLSFLVVLP---VIIFSDVQPD-------LNTCNISWPEPVS--VWSTAFI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVT----YLAPLGLMAMAYFQIFRKLwgrQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMfr 272
Cdd:cd15974 164 IYTavlgFFGPLLVICLCYLLIVIKV---KSSGLRVGSTKRRKSERKVTRMVVIIVVVFVFCWLPFYMLNIVNLIVIL-- 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
6TO7_B      273 qaSDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15974 239 --PEEPAFVGVYFFVVVLSYANSCANPILYGFLSDNFKQSF 277
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
38-302 1.35e-26

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 106.75  E-value: 1.35e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       38 VGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15384  16 IGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFGLYLSTYITVLIS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVM-ECSSVLPELAARTRAFSVCDERWADDLapkiYHSCFF 196
Cdd:cd15384  96 LDRCVAILYPMKRNQAPERVRRMVTVAWILSPIFSIPQAVIFhVERGPFVEDFHQCVTYGFYTAEWQEQL----YNMLSL 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKLW--GRQIPGTTSAEVKQ--------MRARRKTAKMLMVVVLVFALCYLPISVLNVLkr 266
Cdd:cd15384 172 VFMFPIPLVIMVTCYVLIFITLSksSRDFQGLEIYTRNRgpnrqrlfHKAKVKSLRMSAVIVTAFILCWTPYYVIMIW-- 249
                       250       260       270
                ....*....|....*....|....*....|....*.
6TO7_B      267 vFGMFRQASDREAVYAAFTFshwLVYANSAANPIIY 302
Cdd:cd15384 250 -FLFFNPYPLNDILFDVIFF---FGMSNSCVNPLIY 281
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
39-313 2.07e-26

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 105.21  E-value: 2.07e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15060  17 GNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDILCCTASILNLCAIAL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPQAAVMECSsvlPELAARTRAFSVCDERwaddlAPKIYHS--C 194
Cdd:cd15060  97 DRYWAIHDPINYaqKRTLKRVLLMIVVVWALSALISVPPLIGWNDW---PENFTETTPCTLTEEK-----GYVIYSSsgS 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIvtylaPLGLMAMAYFQIFRklwgrqipgTTSAEvkqmrarRKTAKMLMVVVLVFALCYLPISVLNVLkRVFGMFRQA 274
Cdd:cd15060 169 FFI-----PLLIMTIVYVKIFI---------ATSKE-------RRAARTLGIIMGVFVVCWLPFFLMYVI-LPFCETCSP 226
                       250       260       270
                ....*....|....*....|....*....|....*....
6TO7_B      275 SDReaVYAAFTfshWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15060 227 SAK--VVNFIT---WLGYVNSALNPVIYTIFNLDFRRAF 260
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
39-313 2.41e-26

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 105.57  E-value: 2.41e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHH--MRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 116
Cdd:cd15002  16 GNLMVIGILLNNARkgKPSLIDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHACMAAKSFTIAVL 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      117 ALDRWYAICHPL-LFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAArtrafsVCDERWADDLAPKIYHSCF 195
Cdd:cd15002  96 AKACYMYVVNPTkQVTIKQRRITAVVASIWVPACLLPLPQWLFRTVKQSEGVYLC------ILCIPPLAHEFMSAFVKLY 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKLWGRqipGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLnvlkrVFGMFRQAS 275
Cdd:cd15002 170 PLFVFCLPLTFALFYFWRAYGQCQRR---GTKTQNLRNQIRSRKLTHMLLSVVLAFTILWLPEWVA-----WLWLIHIKS 241
                       250       260       270
                ....*....|....*....|....*....|....*....
6TO7_B      276 DREAVYAAFT-FSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15002 242 SGSSPPQLFNvLAQLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
39-313 2.85e-26

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 105.12  E-value: 2.85e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15059  17 GNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDVLFCTASIVNLCAISL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPqaAVMECSSVLPELAartrAFSVCDERwadDLAPKIYHSCff 196
Cdd:cd15059  97 DRYWSVTQAVEYnlKRTPRRAKAMIAAVWIISAVISLP--PLFGWKDEQPWHG----AEPQCELS---DDPGYVLFSS-- 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRklwgrqipgttsaeVKQMRARRKTAkMLMVVVLVFALCYLPISVLNVLKrVFGMFRQASD 276
Cdd:cd15059 166 IGSFYIPLLIMIIVYARIYR--------------AAKRKERRFTL-VLGVVMGAFVLCWLPFFFTYPLV-VVCKTCGVPE 229
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      277 reavyAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15059 230 -----LLFKFFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
39-313 3.88e-26

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 104.93  E-value: 3.88e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15971  17 GNTLVIYVILRYAKMKTVTNIYILNLAIADELFM-LGLPFLAIQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSI 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLlfKSTA----RRALGSILGIWAVSLAIMVPqaaVMECSSVLPElaartRAFSVCDERWADDlaPKIYHSC 194
Cdd:cd15971  96 DRYLAVVHPI--KSAKwrkpRTAKMINMAVWGVSLLVILP---IMIYAGVQTK-----HGRSSCTIIWPGE--SSAWYTG 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 F----FIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSaevKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKrvfgM 270
Cdd:cd15971 164 FiiytFILGFFVPLTIICLCYLFIIIKVKSSGIRVGSS---KRKKSEKKVTRMVSIVVAVFVFCWLPFYIFNVSS----V 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
6TO7_B      271 FRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15971 237 SVSISPTPGLKGMFDFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
39-313 4.35e-26

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 105.08  E-value: 4.35e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15048  17 GNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDYTLCTASALTIVLISL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVMEC---SSVLPElaartrafSVCDERWADDLAPKIYHS 193
Cdd:cd15048  97 DRYLSVTKAVKYRAkqTKRRTVLLMALVWILAFLLYGPAIIGWDLwtgYSIVPT--------GDCEVEFFDHFYFTFITS 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 cffIVTYLAPLGLMAMAYFQIFRKLWGR------QIPGTTSAEVKQMRAR-----------RKTAKMLMVVVLVFALCYL 256
Cdd:cd15048 169 ---VLEFFIPFISVSFFNLLIYLNIRKRsrrrplRSVPILPASQNPSRARsqreqvklrrdRKAAKSLAILVLVFLICWA 245
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
6TO7_B      257 PISVLNVlkrvfgMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15048 246 PYTILTI------IRSFCSGSCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
39-313 5.81e-26

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 104.20  E-value: 5.81e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15325  17 GNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSLCIISI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAImvpqaavmecsSVLPELAARTRAFSvcDERWADDLAPKIYHSCFF 196
Cdd:cd15325  97 DRYIGVSYPLRYPSimTERRGLLALLCVWVLSLVI-----------SIGPLFGWKEPAPE--DETICQITEEPGYALFSA 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFrklwgrqipgttsAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASd 276
Cdd:cd15325 164 LGSFYLPLAIILVMYCRVY-------------VVALKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSIFPAYKPSD- 229
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      277 reavyAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15325 230 -----TVFKITFWLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
39-313 6.03e-26

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 104.11  E-value: 6.03e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15062  17 GNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSLCVISV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAImvpqaavmecsSVLPELAARTRAFSvcDERWADDLAPKIYHSCFF 196
Cdd:cd15062  97 DRYIGVRYPLNYPTivTARRATVALLIVWVLSLVI-----------SIGPLLGWKEPAPA--DEQACGVNEEPGYVLFSS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKLWgrqipgttsaevkQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASd 276
Cdd:cd15062 164 LGSFYLPLAIILVMYCRVYVVAF-------------KFSREKKAAKTLGIVVGAFVLCWFPFFVVLPLGSLFSTLKPPE- 229
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      277 reavyAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15062 230 -----PVFKVVFWLGYFNSCLNPIIYPCSSREFKRAF 261
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
52-313 7.23e-26

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 104.45  E-value: 7.23e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       52 HMRTVTNY--FLVNLSLADVLaTAICLPasLLVDI---TESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICH 126
Cdd:cd14991  28 HSRTWKANtvYLFNLVLADFL-LLICLP--FRIDYylrGEHWIFGEAWCRVNLFMLSVNRSASIAFLTAVALDRYFKVVH 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      127 PLLFKSTA--RRALGSILGIWAVSLAIMVPQAavMECSSVLPELAARTRAFSVcderWADDLAPKIYHSCFFIVTYLAPL 204
Cdd:cd14991 105 PHHRVNRMsvKAAAGVAGLLWALVLLLTLPLL--LSTLLTVNSNKSSCHSFSS----YTKPSLSIRWHNALFLLEFFLPL 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      205 GLMAMAYFQIFRKLWGRQIPGttsaevKQMRARRKTAkMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASDREAVYAAF 284
Cdd:cd14991 179 GLIVFCSVRIACNLRIRQSLG------KQARVQRAIR-LVFLVVIVFVLCFLPSIIAGLLALVFKNLGSCRCLNSVAQLF 251
                       250       260
                ....*....|....*....|....*....
6TO7_B      285 TFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd14991 252 HISLAFTYLNSALDPVIYCFSSPWFRNSL 280
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
39-311 8.11e-26

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 103.50  E-value: 8.11e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15210  17 GNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVSLLTLVLITL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGS--ILGIWAVSLAIMVPQAAVMECSSVLPElaartrafSVCDERWADDLAPKIYHSCFF 196
Cdd:cd15210  97 NRYILIAHPSLYPRIYTRRGLAlmIAGTWIFSFGSFLPLWLGIWGRFGLDP--------KVCSCSILRDKKGRSPKTFLF 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQifrklwgrqipgttsaevkqmRARRKTAKMLMVVVLVFALCYLPISVLNVlkrvfgmfrqASD 276
Cdd:cd15210 169 VFGFVLPCLVIIICYAR---------------------REDRRLTRMMLVIFLCFLVCYLPITLVNV----------FDD 217
                       250       260       270
                ....*....|....*....|....*....|....*
6TO7_B      277 REAVYAAFTFSHWLVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15210 218 EVAPPVLHIIAYVLIWLSSCINPIIYVAMNRQYRQ 252
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
39-313 8.18e-26

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 103.50  E-value: 8.18e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15329  17 GNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDVLLCTASILNLCAISV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPqaavmecssvlPELAARTRAFSVCDERWADDLAPKIYHScff 196
Cdd:cd15329  97 DRYLVITRPLTYavKRTPKRMALMIAIVWLLSALISIP-----------PLFGWKNKVNDPGVCQVSQDFGYQIYAT--- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRklwgrqipgTTSAEvkqmrarRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASD 276
Cdd:cd15329 163 FGAFYIPLIVMLVLYYKIYR---------AAKSE-------RKAIKTLGIIMGAFTLCWLPFFILALLRPFLKPIKCSCI 226
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      277 REAVYAAFTfshWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15329 227 PLWLSRLFL---WLGYANSFLNPIIYAKFNREFRTPF 260
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
39-304 1.57e-25

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 103.40  E-value: 1.57e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15055  17 GNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSLDYILTSASIFNLVLIAI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPqaaVMECSSVLPELAARTRAFSVCDErwaddLAPKIYHSCFF 196
Cdd:cd15055  97 DRYVAVCDPLLYptKITIRRVKICICLCWFVSALYSSV---LLYDNLNQPGLIRYNSCYGECVV-----VVNFIWGVVDL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFR--KLWGRQIPGTTSAEVKQMRAR-------RKTAKMLMVVVLVFALCYLPISVLNvlkrV 267
Cdd:cd15055 169 VLTFILPCTVMIVLYMRIFVvaRSQARAIRSHTAQVSLEGSSKkvskkseRKAAKTLGIVVGVFLLCWLPYYIVS----L 244
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      268 FGMFRQASDreavyAAFTFSHWLVYANSAANPIIYNF 304
Cdd:cd15055 245 VDPYISTPS-----SVFDVLIWLGYFNSCLNPLIYAL 276
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
38-313 1.80e-25

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 103.49  E-value: 1.80e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       38 VGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAIcLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15091  16 VGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTT-MPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMS 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHP---LLFKSTARRALGSILgIWAVSLAIMVP-----------QAAVMECSSVLPElaartrafsvcDERWA 183
Cdd:cd15091  95 VDRYIAVCHPvkaLDFRTPLKAKIINIC-IWLLSSSVGISaivlggtkvreDVDSTECSLQFPD-----------DDYSW 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      184 DDLAPKIyhsCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIpgtTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLnV 263
Cdd:cd15091 163 WDTFMKI---CVFIFAFVIPVLIIIVCYTLMILRLKSVRL---LSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIF-I 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
6TO7_B      264 LKRVFGmfrQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15091 236 LVEALG---SVSHSTAAVSSYYFCIALGYTNSSLNPILYAFLDENFKRCF 282
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
39-311 2.69e-25

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 102.53  E-value: 2.69e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVL-ATAICLPASLLVdITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15088  17 GNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLfMLGMPFLIHQFA-IDGQWYFGEVMCKIITALDANNQFTSTYILTAMS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPllFKSTARR----ALGSILGIWAVSLAIMVPqaaVMECSSVLPELAARTrafsVCDERWADDLAPKIYHS 193
Cdd:cd15088  96 VDRYLAVVHP--IRSTKYRtrfvAKLVNVGLWAASFLSILP---VWVYSSLIYFPDGTT----FCYVSLPSPDDLYWFTI 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 CFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQMRarrKTAKMLMVVVLVFALCYLPISVLNVLKrvFGMFRQ 273
Cdd:cd15088 167 YHFILGFAVPLVVITVCYILILHRLARGVAPGNQSHGSSRTK---RVTKMVILIVVVFIVCWLPFHVVQLVN--LAMNRP 241
                       250       260       270
                ....*....|....*....|....*....|....*...
6TO7_B      274 ASdreAVYAAFTFSHWLVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15088 242 TL---AFEVAYFLSICLGYANSCLNPFVYILVSENFRK 276
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
39-313 2.73e-25

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 102.32  E-value: 2.73e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15323  17 GNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSIVHLCAISL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPQAAVMECSsvlPELAARTRAfSVCDERWAddlapkIYHSCff 196
Cdd:cd15323  97 DRYWSVTQAVEYnlKRTPRRVKAIIVTVWLISAVISFPPLISMYRD---PEGDVYPQC-KLNDETWY------ILSSC-- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRklwgrqipgttsaeVKQMRARRKTAkMLMVVVLVFALCYLPISVLNVLkrvFGMFRQASd 276
Cdd:cd15323 165 IGSFFAPCLIMILVYIRIYR--------------VAKAREKRFTF-VLAVVMGVFVVCWFPFFFSYSL---YGICREAC- 225
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      277 rEAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15323 226 -EVPEPLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
39-313 2.86e-25

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 102.68  E-value: 2.86e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLaTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15970  17 GNSMVIYVILRYAKMKTATNIYILNLAIADEL-LMLSVPFLVTSTLLRHWPFGSLLCRLVLSVDAINMFTSIYCLTVLSI 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSI--LGIWAVSLAIMVP----------QAAVMECSSVLPELAartrafsvcdERWaddl 186
Cdd:cd15970  96 DRYIAVVHPIKAARYRRPTVAKMvnLGVWVFSILVILPiiifsntapnSDGSVACNMQMPEPS----------QRW---- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      187 aPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLwgrQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLkr 266
Cdd:cd15970 162 -LAVFVVYTFLMGFLLPVIAICLCYILIIVKM---RVVALKAGWQQRKRSERKITLMVMMVVTVFVICWMPFYVVQLV-- 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
6TO7_B      267 vfGMFRQASDReavyAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15970 236 --SVFVGQHDA----TVSQLSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
39-313 3.12e-25

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 102.95  E-value: 3.12e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15056  17 GNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDVLLTTASIMHLCCIAL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAIC-HPLLFKSTARRALGSILGIWAVslAIMVPQAAVMECSSVLPELAARTRAFSVCDErwaddlapkiyhSCFFI 197
Cdd:cd15056  97 DRYYAICcQPLVYKMTPLRVAVMLGGCWVI--PTFISFLPIMQGWNHIGIEDLIAFNCASGST------------SCVFM 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      198 V-----------TYLAPLGLMAMAYFQIFR--KLWGRQIPGTTSAEVKQ----------MRARRKTAKMLMVVVLVFALC 254
Cdd:cd15056 163 VnkpfaiicstvAFYIPALLMVLAYYRIYVaaREQAHQIRSLQRAGSSNheadqhrnsrMRTETKAAKTLGIIMGCFCVC 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
6TO7_B      255 YLPISVLNVLKRVFGMfrqasdrEAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15056 243 WAPFFVTNIVDPFIGY-------RVPYLLWTAFLWLGYINSGLNPFLYAFFNKSFRRAF 294
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
39-313 4.82e-25

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 102.43  E-value: 4.82e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15065  16 GNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASILNLCAISL 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAI-MVPQAavMECSSVLPELAARTRAFSVCDERWADDLAP--KIYHS 193
Cdd:cd15065  96 DRYIHIKKPLKYERwmTTRRALVVIASVWILSALIsFLPIH--LGWHRLSQDEIKGLNHASNPKPSCALDLNPtyAVVSS 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 CF-FIVtylaPLGLMAMAYFQIF----------RKLW-------GRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCY 255
Cdd:cd15065 174 LIsFYI----PCLVMLLIYSRLYlyarkhvvniKSQKlpsesgsKFQVPSLSSKHNNQGVSDHKAAVTLGIIMGVFLICW 249
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
6TO7_B      256 LPISVLNVLkrvfGMFRQASDREAVYAAFTfshWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15065 250 LPFFIINII----AAFCKTCIPPKCFKILT---WLGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
39-313 5.69e-25

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 101.51  E-value: 5.69e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15326  17 GNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSLCAISI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAImvpqaavmecsSVLPELAARTRAFSvcderwaDDLAPKIYHSCFF 196
Cdd:cd15326  97 DRYIGVRHSLQYPTivTRKRAILALLGVWVLSTVI-----------SIGPLLGWKEPAPP-------DDKVCEITEEPFY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IV-----TYLAPLGLMAMAYFQIFrklwgrqipgttsAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMF 271
Cdd:cd15326 159 ALfsslgSFYIPLIVILVMYCRVY-------------IVALKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSHL 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
6TO7_B      272 RQASdreavyAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15326 226 KPPE------TLFKIIFWLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
39-313 9.35e-25

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 101.84  E-value: 9.35e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPasllVDITESW-----LFGHALCKVIPYLQAVSVSVAVLTL 113
Cdd:cd15133  17 GNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMP----LELYELWqnypfLLGSGGCYFKTFLFETVCLASILNV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      114 SFIALDRWYAICHPLLFK--STARRALGSILGIWAVSLAIMVPQAAVMECSSvLPELAARTRAFSVCDERWADDLAPKIY 191
Cdd:cd15133  93 TALSVERYIAVVHPLAARtcSTRPRVTRVLGCVWGVSMLCALPNTSLHGIKF-LGSGVPASAQCTVRKPQAIYNMIPQHT 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      192 HSCFFivtyLAPLGLMAMAYFQIFRKL----------WGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVL 261
Cdd:cd15133 172 GHLFF----VLPMAVISVLYLLMALRLarergldatgAGSKIGTRTGQLLQHPRTRAQVTKMLFILVVVFAICWAPFHID 247
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
6TO7_B      262 NVlkrvfgMFRQASD-REAVYAAFTFSH----WLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15133 248 RL------MWSFISDwTDNLHEVFQYVHiisgVFFYLSSAVNPILYNLMSTRFREMF 298
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
39-310 1.10e-24

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 101.06  E-value: 1.10e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15008  16 GNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPGVQIYVLLSICV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVlpelaartrafSVCDERWADDLAPKIYHSCFFIV 198
Cdd:cd15008  96 DRFYTIVYPLSFKVSREKAKKMIAASWLFDAAFVSPALFFYGSNWG-----------PHCNFFLPDSWDGAAYAIIHLLV 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      199 TYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQM--RARRKTAKMLMVVVLVFALCYLPISVLNVLKrvfgmfRQASD 276
Cdd:cd15008 165 GFLVPSILIILFYQKVIKYIWRIGTDGRTVRRTMNIvpRTKVKTIKMFLMLNSMFLLSWLPFYVVQLWH------PRESD 238
                       250       260       270
                ....*....|....*....|....*....|....
6TO7_B      277 REAVYAAFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15008 239 YRQSSLVFLAVTWISFSSSASKPTLYSVYNANFR 272
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
39-313 1.69e-24

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 100.58  E-value: 1.69e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15000  16 GNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLLASVLALCAVSY 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMEcssvlpelaARTRAFSVCDERWADD---LAPKIYHSCF 195
Cdd:cd15000  96 DRLTAIVLPSEARLTKRGAKIVIVITWIVGLLLALPLAIYRS---------YRERQWKNFLETYCAEntqVLPIYWHVII 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLaPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKrvFGMFRQAS 275
Cdd:cd15000 167 TVLVWL-PLGIMLICYSAIFWKLDKYERRVLRREHPSVVRYKKKAAKTLFIVLITFVVCRIPFTALIFYR--YKLVPNDN 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
6TO7_B      276 DREAVYAAFTF----SHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15000 244 TQNSVSGSFHIlwfaSKYLMFLNAAVNPLIYGFTNENFRKAF 285
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
39-313 4.98e-24

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 99.27  E-value: 4.98e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLaTAICLPASlLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15178  17 GNSLVVLVILYNRRSRSSTDVYLLHLAIADLL-FALTLPFW-AVSVVKGWIFGTFMCKLVSLLQEANFYSGILLLACISV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSI-LGIWAVSLAIMVPqaAVMECSSVLPELAARTRAFSVCDERWADD--LAPKIYHScf 195
Cdd:cd15178  95 DRYLAIVHATRALTQKRHLVKFVcAGVWLLSLLLSLP--ALLNRDAFKPPNSGRTVCYENLGNESADKwrVVLRILRH-- 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 fIVTYLAPLGLMAMAYfqifrklwgrqipGTTSAEVKQMRARRKTAKM--LMVVVLVFALCYLP--ISVL-NVLKRVFGM 270
Cdd:cd15178 171 -TLGFLLPLVVMLFCY-------------GFTIKTLLQTRSFQKHRAMrvIFAVVLAFLLCWLPynVTVLiDTLMRTKLI 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
6TO7_B      271 FRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15178 237 TETCELRNHVDVALYVTQILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
39-313 5.09e-24

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 99.63  E-value: 5.09e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLvdITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15068  17 GNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAI-MVPQAAVMECSSVLPELAARTRAFSVCDERWADDLAPKIYHSCF 195
Cdd:cd15068  95 DRYIAIRIPLRYNGlvTGTRAKGIIAICWVLSFAIgLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 -FIVTYLAPLGLMAMAYFQIFRKLwGRQIPGTTSAEVKQMRARRK------TAKMLMVVVLVFALCYLPISVLNvlkrVF 268
Cdd:cd15068 175 nFFACVLVPLLLMLGVYLRIFLAA-RRQLKQMESQPLPGERARSTlqkevhAAKSLAIIVGLFALCWLPLHIIN----CF 249
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
6TO7_B      269 GMFRQASDREA---VYAAFTFSHwlvyANSAANPIIYNFLSGKFREQF 313
Cdd:cd15068 250 TFFCPDCSHAPlwlMYLAIVLSH----TNSVVNPFIYAYRIREFRQTF 293
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
39-313 1.02e-23

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 98.06  E-value: 1.02e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15327  17 GNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTASILSLCVISV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAImvpqaavmecsSVLPELAARTRAFSvcDERWADDLAPKIYHSCFF 196
Cdd:cd15327  97 DRYVGVKHSLKYPTimTERKAGVILVLLWVSSMVI-----------SIGPLLGWKEPPPP--DESICSITEEPGYALFSS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFrklwgrqipgttsAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASd 276
Cdd:cd15327 164 LFSFYLPLMVILVMYFRVY-------------VVALKFSREKKAAKTLAIVVGVFILCWFPFFFVLPLGSFFPALKPSE- 229
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      277 reavyAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15327 230 -----MVFKVIFWLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
39-313 1.23e-23

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 97.73  E-value: 1.23e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15310  17 GNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGvWNFSRICCDVFVTLDVMMCTASILNLCAIS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFK-----STARRALGSILGIWAVSLAIMVPQAAVMECssvlpelaarTRAFSVCDERWADDLapkIYH 192
Cdd:cd15310  97 IDRYTAVVMPVHYQhgtgqSSCRRVSLMITAVWVLAFAVSCPLLFGFNT----------TGDPTVCSISNPDFV---IYS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      193 ScffIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsaevkqmRARRKTAKMLMVVVLVFALCYLPISVLNVLKrvfGMFR 272
Cdd:cd15310 164 S---VVSFYLPFGVTLLVYVRIYVVL----------------LREKKATQMLAIVLGAFIVCWLPFFLTHILN---THCQ 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
6TO7_B      273 QASDREAVYAAFTfshWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15310 222 ACHVPPELYSATT---WLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
39-313 2.43e-23

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 97.01  E-value: 2.43e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15049  17 GNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALDYVASNASVMNLLLISF 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPqaAVMECSSVLPElaaRTRAFSVCDERWADDLAPKIYHScff 196
Cdd:cd15049  97 DRYFSVTRPLTYraKRTPKRAILMIALAWVISFVLWAP--AILGWQYFVGE---RTVPDGQCYIQFLDDPAITFGTA--- 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRklwgrqipgTTSAEvkqmrarRKTAKMLMVVVLVFALCYLPISVLNVLKRVfgmfrqaSD 276
Cdd:cd15049 169 IAAFYLPVLVMTILYWRIYR---------ETARE-------RKAARTLSAILLAFIITWTPYNILVLVSTF-------CA 225
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      277 REAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15049 226 KCIPDTLWSFGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
39-313 3.72e-23

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 97.32  E-value: 3.72e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLvCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLV---DITESWLFG--HALCKVIPYLQAVSVSVAVLTL 113
Cdd:cd14978  17 GNIL-NLVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPyiaDYSSSFLSYfyAYFLPYIYPLANTFQTASVWLT 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      114 SFIALDRWYAICHPLLFK--STARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTRAFSVCDERWADDLAPKIY 191
Cdd:cd14978  96 VALTVERYIAVCHPLKARtwCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTLLRQNETYLLKYY 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      192 HSCFFIVTYLAPLGLMAMAYFQIFRKLW-----GRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKR 266
Cdd:cd14978 176 FWLYAIFVVLLPFILLLILNILLIRALRkskkrRRLLRRRRRLLSRSQRRERRTTIMLIAVVIVFLICNLPAGILNILEA 255
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
6TO7_B      267 VFGmfrQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd14978 256 IFG---ESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-311 3.91e-23

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 96.74  E-value: 3.91e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNtLVCLaVWRNHHMRTVTNY--FLVNLSLADvLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 116
Cdd:cd14999  16 GN-VYTL-VVMCLSMRPRASMyvYILNLALAD-LLYLLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFLTMHASIFTLTVM 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      117 ALDRWYAICHPL-LFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTRafsVCDERWADdLAPKIYHSCF 195
Cdd:cd14999  93 STERYLAVVKPLdTVKRSKSYRKLLAGVIWLLSLLLTLPMAIMIRLVTVEDKSGGSKR---ICLPTWSE-ESYKVYLTLL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAevKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKrVFGMFRQAS 275
Cdd:cd14999 169 FSTSIVIPGLVIGYLYIRLARKYWLSQAAASNSS--RKRLPKQKVLKMIFTIVLVFWACFLPFWIWQLLY-LYSPSLSLS 245
                       250       260       270
                ....*....|....*....|....*....|....*.
6TO7_B      276 DREAVYAAFtFSHWLVYANSAANPIIYNFLSGKFRE 311
Cdd:cd14999 246 PRTTTYVNY-LLTCLTYSNSCINPFLYTLLTKNYKE 280
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
39-313 4.50e-23

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 96.60  E-value: 4.50e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAIcLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15090  17 GNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPL--LFKSTARRALGSILGIWAVSLAIMVPqaaVMECSSVLPELAARTRAFSVCDERWADDLAPKIyhsCFF 196
Cdd:cd15090  96 DRYIAVCHPVkaLDFRTPRNAKIVNVCNWILSSAIGLP---VMFMATTKYRQGSIDCTLTFSHPSWYWENLLKI---CVF 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAY-FQIFRKLWGRQIPGTTSAEvkqmRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMfrqas 275
Cdd:cd15090 170 IFAFIMPVLIITVCYgLMILRLKSVRMLSGSKEKD----RNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTI----- 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
6TO7_B      276 dREAVYAAFT--FSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15090 241 -PETTFQTVSwhFCIALGYTNSCLNPVLYAFLDENFKRCF 279
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
39-313 7.03e-23

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 96.75  E-value: 7.03e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15058  17 GNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASIETLCVIAV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAI-MVPqaAVMECSSVLPELAARTRAFSVCDErWADDLAPKIYHSCf 195
Cdd:cd15058  97 DRYIAITRPLRYQVllTKRRARVIVCVVWIVSALVsFVP--IMNQWWRANDPEANDCYQDPTCCD-FRTNMAYAIASSV- 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 fiVTYLAPLGLMAMAYFQIF----------RKLWGR-----QIPGTTSAEVKQMRARRKTAKMLM----------VVVLV 250
Cdd:cd15058 173 --VSFYIPLLIMIFVYARVFliatrqlqliDKRRLRfqsecPAPQTTSPEGKRSSGRRPSRLTVVkehkalktlgIIMGT 250
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
6TO7_B      251 FALCYLPISVLNVLkRVFgmfrqasDREAVYA-AFTFSHWLVYANSAANPIIYnFLSGKFREQF 313
Cdd:cd15058 251 FTLCWLPFFIANII-NVF-------NRNLPPGeVFLLLNWLGYINSGLNPIIY-CRSPEFRTAF 305
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
39-313 7.79e-23

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 95.52  E-value: 7.79e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15066  16 GNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFSTASILHLCCISV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAI-MVPqaAVMECSSVLPELAARTRAFSVCDErwaddLAPKIYHSCF 195
Cdd:cd15066  96 DRYYAIVQPLEYpsKMTKRRVAIMLANVWISPALIsFLP--IFLGWYTTEEHLQYRKTHPDQCEF-----VVNKIYALIS 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRklwgrqipgttsaevkQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQAS 275
Cdd:cd15066 169 SSVSFWIPCIVMIFTYYRIYL----------------EAKREHKAAKTLGIIMGAFILCWLPFFLWYVTTTLCGDACPYP 232
                       250       260       270
                ....*....|....*....|....*....|....*...
6TO7_B      276 DreaVYAAFTFshWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15066 233 P---ILVSILF--WIGYFNSTLNPLIYAYFNRDFREAF 265
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
39-313 8.32e-23

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 95.64  E-value: 8.32e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15063  17 GNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMCTASILNLCAISL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVP-------QAAVMECSSVLPELAARTRAfsvcderwADDLAPK 189
Cdd:cd15063  97 DRYLAITRPIRYPSlmSTKRAKCLIAGVWVLSFVICFPplvgwndGKDGIMDYSGSSSLPCTCEL--------TNGRGYV 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      190 IYH--SCFFIvtylaPLGLMAMAYFQIFRKlwgrqipgttsaevkqMRARRKTAKMLMVVVLVFALCYLPISVLNVLkrv 267
Cdd:cd15063 169 IYSalGSFYI-----PMLVMLFFYFRIYRA----------------ARMETKAAKTVAIIVGCFIFCWLPFFTVYLV--- 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
6TO7_B      268 fGMFRQASDREAVYAAFtfsHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15063 225 -RAFCEDCIPPLLFSVF---FWLGYCNSALNPCIYALFSRDFRFAF 266
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
39-313 8.74e-23

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 95.77  E-value: 8.74e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15314  17 GNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLFCKIHSSFDITLCTASILNLCFISI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSlaimvpqaAVMECSSVLPEL--AARTRAFSVCDERWADDLAPKIYHSC 194
Cdd:cd15314  97 DRYYAVCQPLLYRSkiTVRVVLVMILISWSVS--------ALVGFGIIFLELniKGIYYNHVACEGGCLVFFSKVSSVVG 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVTYLaPLGLMAMAYFQIF----RKLWGRQIPGTTSAEVKQMRaRRKTAKMLMVVVLVFALCYLPISVLNvlkrVFGM 270
Cdd:cd15314 169 SVFSFYI-PAVIMLCIYLKIFlvaqRQARSIQSARTKSGASSSKM-ERKATKTLAIVMGVFLLCWTPFFLCN----IIDP 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
6TO7_B      271 FRQASDREAVYAAFTfshWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15314 243 FINYSIPPVLIEVLN---WLGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
39-313 9.53e-23

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 95.40  E-value: 9.53e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15322  17 GNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAartrAFSVCDERWAddlapkIYHSCff 196
Cdd:cd15322  97 DRYWSITQAIEYnlKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQPEGP----ICKINDEKWY------IISSC-- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFrklwgrqipgttsaEVKQMRARRKTAkMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASd 276
Cdd:cd15322 165 IGSFFAPCLIMVLVYIRIY--------------QIAKNREKRFTF-VLAVVIGVFVICWFPFFFTYTLTAVCDCSVPET- 228
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      277 reavyaAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15322 229 ------LFKFFFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
39-313 1.72e-22

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 95.25  E-value: 1.72e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15972  17 GNTLVIYVVLRYSASESVTNIYILNLALADELFM-LGLPFLAAQNALSYWPFGSFMCRLVMTVDAINQFTSIFCLTVMSV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPqaaVMECSSVlpelaarTRAFSVCDERWADDLApkIYHSCFF 196
Cdd:cd15972  96 DRYLAVVHPIRSSKwrKPPVAKTVNATVWALSFLVVLP---VVIFSGV-------PGGMGTCHIAWPEPAQ--VWRAGFI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVT----YLAPLGLMAMAYFQIFRKL--WGRQIPGTTSaevKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGM 270
Cdd:cd15972 164 IYTatlgFFCPLLVICLCYLLIVVKVrsSGRRVRATST---KRRGSERKVTRMVVIVVAAFVLCWLPFYALNIVNLVCPL 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
6TO7_B      271 frqaSDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15972 241 ----PEEPSLFGLYFFVVVLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
39-313 1.85e-22

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 94.80  E-value: 1.85e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15050  17 LNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIFSLFILCI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPL--LFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPelaaRTRAFSVCDERWADDLAPKIYHScff 196
Cdd:cd15050  97 DRYRSVQQPLkyLKYRTKTRASLMISGAWLLSFLWVIPILGWHHFARGGE----RVVLEDKCETDFHDVTWFKVLTA--- 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFrklwgrqipgttsaevKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLkrvfgmfrQASD 276
Cdd:cd15050 170 ILNFYIPSLLMLWFYAKIF----------------KAVNRERKAAKQLGFIMAAFILCWIPYFILFMV--------IAFC 225
                       250       260       270
                ....*....|....*....|....*....|....*...
6TO7_B      277 REAVYAAF-TFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15050 226 KNCCNENLhMFTIWLGYINSTLNPFIYPLCNENFKKTF 263
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
39-310 2.72e-22

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 94.95  E-value: 2.72e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLaTAICLPASLL-VDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15131  17 GNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLL-IFLCMPLDLYrLWQYRPWNFGDLLCKLFQFVSESCTYSTILNITALS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVmecssVLPELAARTRAFSVCDERWADD------LAPK 189
Cdd:cd15131  96 VERYFAICFPLRAKVvvTKRRVKLVILVLWAVSFLSAGPIFVL-----VGVEHENGTNPIDTNECKATEYavrsglLTIM 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      190 IYHSCFFivtYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLkrVFG 269
Cdd:cd15131 171 VWVSSVF---FFLPVFCLTVLYSLIGRKLWRRRRENIGPNASHRDKNNRQTVKMLAVVVFAFVLCWLPFHVGRYL--FSK 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
6TO7_B      270 MFRQASDREAVYAAFT--FSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15131 246 SFEAGSLEIALISQYCnlVSFVLFYLSAAINPILYNIMSKKYR 288
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
54-313 3.31e-22

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 94.29  E-value: 3.31e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       54 RTVTNYFLVNLSLADVLATAiCLP---ASLLVDitESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLF 130
Cdd:cd14974  31 RTVNTVWFLNLALADFLFCL-FLPfliVYIAMG--HHWPFGSVLCKLNSFVISLNMFASVFLLTAISLDRCLLVLHPVWA 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      131 KS--TARRALGSILGIWAVSLAIMVPqaavmecSSVLPELA---ARTRAFSVCDERwaDDLAPKIYHSCF---FIVTYLA 202
Cdd:cd14974 108 QNhrTVRLASVVCVGIWILALVLSVP-------YFVFRDTVthhNGRSCNLTCVED--YDLRRSRHKALTvirFLCGFLL 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      203 PLGLMAMAYFQIFRKLWGRqipgttsaevkQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVfgmfRQASDREAVYA 282
Cdd:cd14974 179 PLLIIAICYSVIAVKLRRK-----------RLAKSSKPLRVLLAVVVAFFLCWLPYHVFALLELV----AAAGLPEVVLL 243
                       250       260       270
                ....*....|....*....|....*....|.
6TO7_B      283 AFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd14974 244 GLPLATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
39-313 3.60e-22

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 94.58  E-value: 3.60e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15958  17 GNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLCVTASIETLCVIAI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAImvpqaavmecsSVLPELAARTRAFSVCDERWADD------LAPKI 190
Cdd:cd15958  97 DRYLAITSPFRYQSllTRARAKGIVCTVWAISALV-----------SFLPIMMHWWRDEDDQALKCYEDpgccdfVTNRA 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      191 YHSCFFIVTYLAPLGLMAMAYFQIFR----------KLWGRQIPGTTSAEVKQMRA--------RRKTAKMLMVVVLVFA 252
Cdd:cd15958 166 YAIASSIISFYIPLLIMIFVYLRVYReakkqikkidKCEGRFHNTLTGLGRKCKRRpsrilalrEQKALKTLGIIMGVFT 245
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
6TO7_B      253 LCYLPISVLNVLkRVFgmFRQASDREavyaAFTFSHWLVYANSAANPIIYnFLSGKFREQF 313
Cdd:cd15958 246 LCWLPFFLVNVV-NVF--NRELVPDW----LFVFFNWLGYANSAFNPIIY-CRSPDFRKAF 298
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
39-313 5.04e-22

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 94.23  E-value: 5.04e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHAL---CKVIPYLQAvsvsvAVLTLSF 115
Cdd:cd15069  17 GNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFHSCLflaCFVLVLTQS-----SIFSLLA 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      116 IALDRWYAICHPLLFKS--TARRALGSILGIWAVSLAI-MVPQAAVMECSSVLP---ELAARTRAFSVCDERWA-DDLAP 188
Cdd:cd15069  92 VAVDRYLAIKVPLRYKSlvTGKRARGVIAVLWVLAFGIgLTPFLGWNKAMSATNnstNPADHGTNHSCCLISCLfENVVP 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      189 KIYHSCF-FIVTYLAPLGLMAMAYFQIFRkLWGRQIPGTTSAEVKQMRARRK--TAKMLMVVVLVFALCYLPISVLNVLK 265
Cdd:cd15069 172 MSYMVYFnFFGCVLPPLLIMLVIYIKIFL-VACRQLQRTELMDHSRTTLQREihAAKSLAIIVGIFALCWLPVHILNCIT 250
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
6TO7_B      266 RVFGMFRQASDREAVYAAFTFSHwlvyANSAANPIIYNFLSGKFREQF 313
Cdd:cd15069 251 LFQPEFSKSKPKWAMNVAILLSH----ANSVVNPIVYAYRNRDFRYTF 294
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
57-313 5.85e-22

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 93.54  E-value: 5.85e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       57 TNYFLVNLSLADvLATAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLlfkstar 135
Cdd:cd15168  35 SAIYMFNLAVSD-LLYLLSLPFLIYYYANGDhWIFGDFMCKLVRFLFYFNLYGSILFLTCISVHRYLGICHPL------- 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      136 RALGSILGIWAVSLAIMVPQAAVMECSSVLPELA-ARTRAFSVCDERWADDLAP--KIYHSCFFIVTYLAPLGLMAMAYF 212
Cdd:cd15168 107 RSLGKLKKRHAVAISVAVWILVLLQLLPILFFATtGRKNNRTTCYDTTSPEELNdyVIYSMVLTGLGFLLPLLIILACYG 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      213 QIFRKLWGRQIPGTTSAevkqmrARRKTAKMLMVVVLVFALCYLPISV---LNVLKRVFGMFRQASDREAVYAAFTFSHW 289
Cdd:cd15168 187 LIVRALIRKLGEGVTSA------LRRKSIRLVIIVLALFAVCFLPFHVtrtINLAARLLSGTASCATLNGIYVAYKVTRP 260
                       250       260
                ....*....|....*....|....
6TO7_B      290 LVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15168 261 LASLNSCLNPLLYFLAGDKFRRRL 284
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
39-313 6.46e-22

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 93.60  E-value: 6.46e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADvLATAICLPasLLVDITES---WLFGHALCKVIPYLQAVSVSVAVLTLSF 115
Cdd:cd14985  17 GNLFVVWVFLFPRGPKRVADIFIANLAAAD-LVFVLTLP--LWATYTANqydWPFGAFLCKVSSYVISVNMFASIFLLTC 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      116 IALDRWYAICHPLLFK--STARRALGSILGIWAVSlaimvpqaavmeCSSVLPELAARTRAF------SVCDERWADDLA 187
Cdd:cd14985  94 MSVDRYLAIVHPVASRrlRRRRQARVTCALIWVVA------------CLLSLPTFLLRSLQAienlnkTACIMLYPHEAW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      188 PKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQipgttSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRV 267
Cdd:cd14985 162 HFGLSLELNILGFVLPLLIILTCYFHIARSLRKRY-----ERTGKNGRKRRKSLKIIFALVVAFLVCWLPFHFFKFLDFL 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
6TO7_B      268 FGM--FRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd14985 237 AQLgaIRPCFWELFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
39-313 6.55e-22

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 93.38  E-value: 6.55e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15973  17 GNSMVIFVILRYAKMKTATNIYILNLAIADELFM-LSVPFLAASAALQHWPFGSAMCRTVLSVDGINMFTSVFCLTVLSV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSI--LGIWAVSLAIMVPQAavmecssVLPELAARTRAFSVCDERWADDLAPKIYHSCFF 196
Cdd:cd15973  96 DRYIAVVHPLRAARYRRPTVAKMinICVWILSLLVISPII-------IFADTATRKGQAVACNLIWPHPAWSAAFVIYTF 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKLwgrQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKrvfgMFRQASD 276
Cdd:cd15973 169 LLGFLLPVLAIGLCYILIIGKM---RAVALKAGWQQRRKSEKKITRMVLMVVTVFVICWMPFYVVQLLN----LFLPRLD 241
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      277 REAVYAAFTFShwlvYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15973 242 ATVNHASLILS----YANSCANPILYGFLSDNFRRSF 274
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
39-313 6.81e-22

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 93.43  E-value: 6.81e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLaTAICLPAsLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd14984  17 GNSLVLLVLLYYRKLRSMTDVYLLNLALADLL-FVLTLPF-WAVYAADGWVFGSFLCKLVSALYTINFYSGILFLACISI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICH--PLLFKSTARRALGSILGIWAVSLAIMVPQ---------AAVMECSSVLPELAARTrafsvcderWADDLA 187
Cdd:cd14984  95 DRYLAIVHavSALRARTLLHGKLTCLGVWALALLLSLPEfifsqvseeNGSSICSYDYPEDTATT---------WKTLLR 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      188 PKIYHSCFFIvtylaPLGLMAMAYFQIFRKLwgrqipgttsaEVKQMRARRKTAKMLMVVVLVFALCYLPISV---LNVL 264
Cdd:cd14984 166 LLQNILGFLL-----PLLVMLFCYSRIIRTL-----------LRARNHKKHRALRVIFAVVVVFFLCWLPYNIvllLDTL 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
6TO7_B      265 KRVFGMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd14984 230 QLLGIISRSCELSKSLDYALQVTESLAFSHCCLNPVLYAFVGVKFRKYL 278
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
39-314 7.45e-22

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 93.48  E-value: 7.45e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15307  17 GNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTASIMHLCTISV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPqaavmeCSSVLPELAARTRAFSVCderwadDLAPKIYHSCFF 196
Cdd:cd15307  97 DRYLSLRYPMRFgrNKTRRRVTLKIVFVWLLSIAMSLP------LSLMYSKDHASVLVNGTC------QIPDPVYKLVGS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKLWGRQipgttSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASD 276
Cdd:cd15307 165 IVCFYIPLGVMLLTYCLTVRLLARQR-----SRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERIS 239
                       250       260       270
                ....*....|....*....|....*....|....*...
6TO7_B      277 REavyaAFTFSHWLVYANSAANPIIYNFLSGKFREQFK 314
Cdd:cd15307 240 HW----VFDVVTWLGYASSMVNPIFYTIFNKVFRQAFK 273
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
39-313 8.76e-22

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 92.79  E-value: 8.76e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15309  17 GNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCTASILNLCAISI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFK---STARRALGSILGIWAVSLAIMVPQAavmecssvlpeLAARTRAFSVCderWADDLAPKIYHScf 195
Cdd:cd15309  97 DRYTAVAMPMLYNtrySSKRRVTVMISVVWVLSFAISCPLL-----------FGLNNTDQNEC---IIANPAFVVYSS-- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 fIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsaevkqmRARRKTAKMLMVVVLVFALCYLPISVLNVLKrvfgMFRQAS 275
Cdd:cd15309 161 -IVSFYVPFIVTLLVYVQIYIVL----------------QKEKKATQMLAIVLGVFIICWLPFFITHILN----MHCDCN 219
                       250       260       270
                ....*....|....*....|....*....|....*...
6TO7_B      276 DREAVYAAFTfshWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15309 220 IPPALYSAFT---WLGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
39-311 1.02e-21

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 93.00  E-value: 1.02e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15318  17 GNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHLCFISI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTRAFSVCDErwaddLAPKIYHSCFF 196
Cdd:cd15318  97 DRHCAICDPLLYpsKFTIRVACIFIAAGWLVPTVYTSVFLYTKAVEEGLAELLTSVPCVGSCQL-----LYNKLWGWLNF 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVtYLAPLGLMAMAYFQIF--RKLWGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQA 274
Cdd:cd15318 172 PV-FFIPCLIMIGLYVKIFivAKRQARAIASLLSDTNGASKRERKAAKTLGIAVGVYLLCWLPFTIDTMVDSLLNFITPP 250
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      275 sdreavyAAFTFSHWLVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15318 251 -------LLFDIIIWFAYFNSACNPLIYVFSYPWFRK 280
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
23-313 3.19e-21

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 91.89  E-value: 3.19e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       23 WVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQ 102
Cdd:cd15959   1 WLAGALLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      103 AVSVSVAVLTLSFIALDRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVpqAAVMECSSVLPELAARTRAFSvcDE 180
Cdd:cd15959  81 VLCVTASIETLCAIAVDRYLAITNPLRYEAlvTKRRARTAVCLVWAISAAISF--LPIMNQWWRDGADEEAQRCYD--NP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      181 RWADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQIF----------RKLWGRqIPGTTSAEVKQMRARR------------ 238
Cdd:cd15959 157 RCCDFVTNMPYAIVSSTVSFYVPLLVMIFVYVRVFvvatrqvrliRKDKVR-FPPEESPPAESRPACGrrpsrllaikeh 235
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
6TO7_B      239 KTAKMLMVVVLVFALCYLPISVLNVLKrVFGmfRQASDREavyaAFTFSHWLVYANSAANPIIYnFLSGKFREQF 313
Cdd:cd15959 236 KALKTLGIIMGTFTLCWLPFFVANIIK-VFC--RSLVPDP----AFLFLNWLGYANSAFNPIIY-CRSPDFRSAF 302
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
39-311 3.35e-21

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 91.63  E-value: 3.35e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15083  17 GNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSINTLAAIAV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPL--LFKSTARRALGSILGIWAVSLAIMVPQAavMECSSVLPELAARTRAFSVCderwADDLAPKIYHSCFF 196
Cdd:cd15083  97 DRYLVITRPMkaSVRISHRRALIVIAVVWLYSLLWVLPPL--FGWSRYVLEGLLTSCSFDYL----SRDDANRSYVICLL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFR----------KLWGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLkr 266
Cdd:cd15083 171 IFGFVLPLLIIIYCYSFIFRavrrhekamkEMAKRFSKSELSSPKARRQAEVKTAKIALLLVLLFCLAWTPYAVVALI-- 248
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
6TO7_B      267 vfGMFRQASDREAVYAAFTfshwLVYANSAA--NPIIYNFLSGKFRE 311
Cdd:cd15083 249 --GQFGYLEVLTPLATAIP----AAFAKTSAiyNPVIYAFSHPKFRR 289
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-313 5.34e-21

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 91.45  E-value: 5.34e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15976  17 GNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTA--RRALGSILGIWAVSLAIMVPQAAVMEcssvLPELAARTRAFSVC----DERWADDLAPKIYH 192
Cdd:cd15976  97 DRYRAVASWSRIKGIGvpKWTAVEIVLIWVVSIILAVPEAIGFD----MITMDYKGELLRICllhpIQKTAFMQFYKTAK 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      193 SCFFIVTYLA-PLGLMAMAY----FQIFRKLWGRQIpgttsAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRV 267
Cdd:cd15976 173 DWWLFSFYFClPLACTAVFYtlmtCEMLRKKNGMQI-----ALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLT 247
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
6TO7_B      268 FGMFRQASDREAVYAAFTFSHW---LVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15976 248 IYDEKDPNRCELLSFFLVLDYIginMASLNSCINPIALYLVSKRFKNCF 296
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
39-311 5.57e-21

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 90.93  E-value: 5.57e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15336  17 GNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITSMITLLAISL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPqaAVMECSSVLPElAARTrafSVCDERWADDLAPKIYHSCFF 196
Cdd:cd15336  97 DRYLVITKPLASirWVSKKRAMIIILLVWLYSLAWSLP--PLFGWSAYVPE-GLLT---SCTWDYMTFTPSVRAYTMLLF 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKL---------WGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVL--- 264
Cdd:cd15336 171 CFVFFIPLGIIIYCYLFIFLAIrstgrevqkLGSQDRKEKAKQYQRMKNEWKMAKIAFVVILLFVLSWSPYACVALIawa 250
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
6TO7_B      265 ----------KRVFGMFRQASdreAVYaaftfshwlvyansaaNPIIYNFLSGKFRE 311
Cdd:cd15336 251 gyahlltpymKSVPAVIAKAS---AIY----------------NPIIYAITHPKYRE 288
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
39-313 5.86e-21

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 91.37  E-value: 5.86e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPasllVDITESW-----LFGHALCKVIPYLQAVSVSVAVLTL 113
Cdd:cd15358  17 GNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMP----LELYEMWsnypfLLGAGGCYFKTLLFETVCFASILNV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      114 SFIALDRWYAICHPLLFKSTARRALGS--ILGIWAVSLAIMVPQAAV-------MECSSVLPELAARTrafsVCDERWAD 184
Cdd:cd15358  93 TALSVERYIAVVHPLKAKYVVTRTHAKrvIGAVWVVSILCSIPNTSLhgifqltVPCRGPVPDSATCM----LVKPRWMY 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      185 DLAPKIYHSCFFIVtylaPLGLMAMAYF----QIFRKLWGRQIPGTTSAEV---------KQMRARRKTAKMLMVVVLVF 251
Cdd:cd15358 169 NLIIQITTLLFFFL----PMGTISVLYLliglQLKREKMLLVLEAKGSKAGdsyqhrriqQEKRRRRQVTKMLFVLVVVF 244
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
6TO7_B      252 ALCYLPISVLNVLKRVFGMFrqasdREAVYAAFTFSHW----LVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15358 245 GICWAPFHTDRLMWSFISQW-----TGELHLAFQYVHIisgvFFYLSSAANPVLYNLMSTRFREMF 305
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
39-306 7.58e-21

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 90.21  E-value: 7.58e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15398  17 GNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQCVSVMVSTLMLMSIAI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQA---AVMECSSVLPELAARTRafSVCDERWADDLAPKIYHSCF 195
Cdd:cd15398  97 VRYHMIKHPLSNHLTANHGYFLLGTVWTLGFTICSPLPvfhKIVDLSETFNLESLKNK--YLCIESWPSDSYRIAFTISL 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsaevkqMRARRKTAKmLMVVVLVFALCYLPISVLNVLKRVFGMFRQAS 275
Cdd:cd15398 175 LFVQYILPLVCLTVSHTSVCRSV---------------KRSRSVFYR-LTIVILAFAVSWMPLHLFHLVTDFNANLISNR 238
                       250       260       270
                ....*....|....*....|....*....|.
6TO7_B      276 DREAVYAaftFSHWLVYANSAANPIIYNFLS 306
Cdd:cd15398 239 HFKLVYC---ICHLLGMLSCCLNPILYGFLN 266
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
39-313 1.43e-20

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 89.73  E-value: 1.43e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATaICLPASLLVDITEsWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15182  17 GNGLVLWILVKYEKLKTLTNIFILNLAISDLLFT-FTLPFWASYHSSG-WIFGEILCKAVTSIFYIGFYSSILFLTLMTI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPL--LFKSTARRALGSILGIWAVSLAIMVPQAavmecssVLPELAARTRAFSVCDErwaDDLAPKIYHSCFF 196
Cdd:cd15182  95 DRYLAVVHPLsaLRSRKLRYASLVSVAVWVISILASLPEL-------ILSTVMKSDEDGSLCEY---SSIKWKLGYYYQQ 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKLWGrqipgttsaevKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASD 276
Cdd:cd15182 165 NLFFLIPLGIIVYCYVRILQTLMR-----------TRTMRKHRTVKLIFVIVLVFFLSWAPYNIVIFLRSLKDLTIPICE 233
                       250       260       270
                ....*....|....*....|....*....|....*...
6TO7_B      277 RE-AVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15182 234 CSkQLDYAFYICRNIAFSHCCLNPVFYVFVGVKFRNHL 271
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
39-313 1.65e-20

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 90.45  E-value: 1.65e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRT-VTNYFLVNLSLADVLATAICLPASLLVDITESWLFGhALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15320  18 GNTLVCAAVIRFRHLRSkVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMCSTASILNLCVIS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLF--KSTARRALGSILGIWAVSLAI-MVP-QAAVMECSSVLP-ELAARTRAFSVCDerwADDLAPKIYH 192
Cdd:cd15320  97 VDRYWAISSPFRYerKMTPKVAFIMISVAWTLSVLIsFIPvQLNWHKAKPTSFlDLNASLRDLTMDN---CDSSLNRTYA 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      193 SCFFIVTYLAPLGLMAMAYFQIFRkLWGRQIPGTTSAEVKQMRARR----------------------------KTAKML 244
Cdd:cd15320 174 ISSSLISFYIPVAIMIVTYTRIYR-IAQKQIRRISALERAAVHAKNcqnstgnrgsgdcqqpessfkmsfkretKVLKTL 252
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
6TO7_B      245 MVVVLVFALCYLPISVLNVLKRvfgmFRQASDREAV---YAAFTFSHWLVYANSAANPIIYNFlSGKFREQF 313
Cdd:cd15320 253 SVIMGVFVCCWLPFFILNCMVP----FCKPTSTEPFcisSTTFDVFVWFGWANSSLNPIIYAF-NADFRKAF 319
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
39-313 1.77e-20

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 89.21  E-value: 1.77e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15321  23 GNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCTSSIVHLCAISL 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPQAAVMECSSvlPELAARTRAfSVCDERWaddlapkiYHSCFF 196
Cdd:cd15321 103 DRYWSVSRAIEYnsKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQK--DEQGGLPQC-KLNEEAW--------YILSSS 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFrklwgrqipgttsaEVKQMRARRKTAkMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASD 276
Cdd:cd15321 172 IGSFFAPCLIMILVYLRIY--------------LIAKNREKRFTF-VLAVVIGVFVLCWFPFFFSYSLGAICPELCKVPH 236
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      277 reavyAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15321 237 -----SLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
39-313 2.64e-20

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 89.34  E-value: 2.64e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15312  17 GNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMMLSTTSIFHLCFIAV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKST-ARRALGSILGI-WAVSLAImvpqAAVMECSSV----LPELAARTRAFSVC----DERWAdDLAP 188
Cdd:cd15312  97 DRYYAVCDPLHYRTKiTTPVIKVFLVIsWSVPCLF----AFGVVFSEVnlegIEDYVALVSCTGSCvlifNKLWG-VIAS 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      189 KIyhsCFFIvtylaPLGLMAMAYFQIF---RKlWGRQIPGTTSAEVKQMR------ARRKTAKMLMVVVLVFALCYLPIS 259
Cdd:cd15312 172 LI---AFFI-----PGTVMIGIYIKIFfvaRK-HAKVINNRPSVTKGDSKnklskkKERKAAKTLSIVMGVFLLCWLPFF 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
6TO7_B      260 VLNVLKRVFGMfrqaSDREAVYAAFTfshWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15312 243 VATLIDPFLNF----STPVDLFDALV---WLGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
39-313 3.45e-20

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 88.99  E-value: 3.45e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15195  17 GNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGMYLSSFMLVVIAL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPE--LAARTRAFSVCDERWADdlapKIYHSCFF 196
Cdd:cd15195  97 DRVFAILSPLSANQARKRVKIMLTVAWVLSALCSIPQSFIFSVLRKMPEqpGFHQCVDFGSAPTKKQE----RLYYFFTM 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAY----FQIFRKlwGRQIPGTTSAEVKQM------RARRKTAKMLMVVVLVFALCYLPISVLNVLKR 266
Cdd:cd15195 173 ILSFVIPLIITVTCYllilFEISKM--AKRARDTPISNRRRSrtnsleRARMRTLRMTALIVLTFIVCWGPYYVLGLWYW 250
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
6TO7_B      267 VFGMFRQASDREAVYAAFTFShwlvYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15195 251 FDKESIKNLPPALSHIMFLLG----YLNPCLHPIIYGVFMKEIRNWI 293
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
39-313 3.53e-20

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 88.39  E-value: 3.53e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15324  17 GNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCTSSIVHLCAISL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPQaavmecssvLPELAARTRAFSVCDERWAddlapkIYHSCff 196
Cdd:cd15324  97 DRYWSVTKAVSYnlKRTPKRIKRMIAVVWVISAVISFPP---------LLMTKHDEWECLLNDETWY------ILSSC-- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRklwgrqipgttsaeVKQMRARRKTAkMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASD 276
Cdd:cd15324 160 TVSFFAPGLIMILVYCKIYR--------------VAKMREKRFTF-VLAVVMGVFVLCWFPFFFTYSLHAVCRKRCGIPD 224
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      277 reavyAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15324 225 -----ALFNLFFWIGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
39-313 3.77e-20

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 88.66  E-value: 3.77e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15317  17 GNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLLLCTTSIFHLCFIAI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAV----SLAIMVPQAAVMECSSVLPELAARTRAFSVCDERWADDLAPKIYH 192
Cdd:cd15317  97 DRYYAVCDPLRYpsKITVQVAWRFIAIGWLVpgiyTFGLIYTGANDEGLEEYSSEISCVGGCQLLFNKIWVLLDFLTFFI 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      193 SCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFR 272
Cdd:cd15317 177 PCLIMIGLYAKIFLVARRQARKIQNMEDKFRSSEENSSKASASRERKAAKTLAIVMGIFLFCWLPYFIDTIVDEYSNFIT 256
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
6TO7_B      273 QAsdreAVYAAFTfshWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15317 257 PA----IVFDAVI---WLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
39-307 6.25e-20

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 88.29  E-value: 6.25e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15388  17 SNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFFQVLPQLVWDITDRFRGPDVLCRLVKYLQVVGMFASSYMIVAMTF 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLL-FKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAArtrafsvCDERWADDLAPKIYHSCFFI 197
Cdd:cd15388  97 DRHQAICRPMVtFQKGRARWNGPVCVAWAISLILSLPQVFIFSKVEVAPGVYE-------CWACFIEPWGLKAYVTWITL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      198 VTYLAPLGLMAMAYFQIFRKLWGRQIPGTT--SAEVKQM--------------RARRKTAKMLMVVVLVFALCYLPIsvl 261
Cdd:cd15388 170 VVFVLPTLIITVCQVLIFKEIHINIYLKSQiiVAVVKKKqllssrassvaevsKAMIKTVKMTLVIVLVYVLCWAPF--- 246
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
6TO7_B      262 nVLKRVFGMFRQASDREAvyAAFTFSHWLVYANSAANPIIYNFLSG 307
Cdd:cd15388 247 -FLVQLWSVWDPKAPTEG--ATFTILMLLASLNSCTNPWIYMAFSS 289
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
39-313 7.73e-20

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 88.47  E-value: 7.73e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRT-VTNYFLVNLSLADVLATAICLPASLLVDITESWLFGhALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15319  17 GNILVCAAVVRFRHLRSkVTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVIS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLF--KSTARRALGSILGIWAVSLAI-MVPQAAVMECSSVLPELAARTRAFSVCDERWADDLAPKIYHSC 194
Cdd:cd15319  96 VDRYWAISSPFRYerKMTQRVALVMISVAWTLSVLIsFIPVQLNWHKDSGDDWVGLHNSSISRQVEENCDSSLNRTYAIS 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVTYLAPLGLMAMAYFQIFR--KLWGRQIPG-TTSAEVKQ------------------MRARRKTAKMLMVVVLVFAL 253
Cdd:cd15319 176 SSLISFYIPVAIMIVTYTRIYRiaQIQIRRISSlERAAEHAQscrsnridchhhtslrtsIKKETKVLKTLSVIMGVFVC 255
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
6TO7_B      254 CYLPISVLNVLkrVFGMFRQASDREAVY-----AAFTFSHWLVYANSAANPIIYNFlSGKFREQF 313
Cdd:cd15319 256 CWLPFFILNCM--VPFCDRPPADPDAGLpcvseTTFDVFVWFGWANSSLNPIIYAF-NADFRKVF 317
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-310 9.71e-20

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 87.55  E-value: 9.71e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLaTAICLPASLL-VDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15132  17 GNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLL-ILLCLPFDLYrLWKSRPWIFGEFLCRLYHYISEGCTYATILHITALS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFK--STARRALGSILGIWAVSLAIMVPQAAVMECSSvlPELAARTRAFSVCDERWADdLAPKIYHSCF 195
Cdd:cd15132  96 IERYLAICFPLRAKvlVTRRRVKCVIAALWAFALLSAGPFLFLVGVEQ--DNNIHPDDFSRECKHTPYA-VSSGLLGIMI 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVT--YLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLkrvfgmFRQ 273
Cdd:cd15132 173 WVTTtyFFLPMLCLSFLYGFIGRKLWKSKNDLRGPNAAARERSHRQTVRILAVVVLAFIICWLPFHIGRIL------FAN 246
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
6TO7_B      274 ASDREAVYAAFTF---SHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15132 247 TEDYRTMMFSQYFnivAMQLFYLSASINPILYNLISRKYR 286
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
39-313 9.79e-20

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 87.44  E-value: 9.79e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLaTAICLPAsLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15180  17 GNGLVLAVLLQKRRNLSVTDTFILHLALADIL-LLVTLPF-WAVQAVHGWIFGTGLCKLAGAVFKINFYCGIFLLACISF 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHP--LLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVlpELAART---RAFSVCDERWADDLapkiyHS 193
Cdd:cd15180  95 DRYLSIVHAvqMYSRKKPMLVHLSCLIVWLFCLLLSIPDFIFLEATKD--PRQNKTecvHNFPQSDTYWWLAL-----RL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 CFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttSAEVKQMRARRKTAkMLMVVVLVFALCYLPISV---LNVLKRVFGM 270
Cdd:cd15180 168 LYHIVGFLLPLAVMVYCYTSILLRL---------LRSSQGFQKQRAIR-VIVAVVVVFFLCWTPYNIallVDTLIDLSVL 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
6TO7_B      271 FRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15180 238 DRNCGTESRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
52-313 1.50e-19

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 87.60  E-value: 1.50e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       52 HMRTVTNYFLVNLSLADVLATAICLPASL--LVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLL 129
Cdd:cd15355  33 HLQSTVHYHLASLALSDLLILLLAMPVELynFIWVHHPWAFGDAACRGYYFLRDACTYATALNVASLSVERYLAICHPFK 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      130 FKS--TARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTrafsVCdERWADDLAPKIYHSCFFIVTYLAPL--- 204
Cdd:cd15355 113 AKSlmSRSRTKKFISAIWLASALLAIPMLFTMGEQNRSGTHPGGL----IC-TPIVDTSTLKVVIQVNAFLSFLFPMlvi 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      205 ----GLMAMAYFQIFRK---------LWGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVlnvlKRVfgMF 271
Cdd:cd15355 188 svlnTLIANQLTVMVNQaeqenqvctIGGQRTVLSVSMEPGRVQSLRHGVLVLRAVVIAFVVCWLPYHV----RRL--MF 261
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
6TO7_B      272 RQASDREAVYAAFTFSHW-------LVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15355 262 CYVSDEQWTTFLYDFYHYfymltnvLFYVSSAINPILYNLVSANFRQIF 310
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
44-310 2.27e-19

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 86.28  E-value: 2.27e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       44 CLAVW---RNHHMRTVTNYFLVNLSLADVLATaICLPasLLVDIT---ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15160  19 CLALWvlyLQIKKENVLGVYLLNLSLSDLLYI-LTLP--LWIDYTanhHNWTFGPLSCKVVGFFFYTNIYASIGFLCCIA 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKS--TARRALGSILGIWAVslaIMVPQAAVMEcssvLPELAARTRAFSVCDERWADDLAPKIYHSCF 195
Cdd:cd15160  96 VDRYLAVVHPLRFRGlrTRRFALKVSASIWVL---ELGTHSVFLG----HDELFRDEPNHTLCYEKYPMEGWQASYNYAR 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKLwgRQIPGTTSAEvkqmraRRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQA- 274
Cdd:cd15160 169 FLVGFLIPLSLILFFYRRVLRAV--RQSPSLEREE------KRKIIGLLLSIVVIFLLCFLPYHVVLLVRSVIELVQNGl 240
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      275 -SDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15160 241 cGFEKRVFTAYQISLCLTSLNCVADPILYIFVTEDVR 277
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
39-313 4.07e-19

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 85.48  E-value: 4.07e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15331  17 GNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPEVCDMWISMDVLCCTASILHLVAIAL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAI-CHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMEcssvLPELAARTRAFSVCdeRWADDLAPKIYHSCffi 197
Cdd:cd15331  97 DRYWAVtNIDYIRRRTAKRILIMIAVVWFVSLIISIAPLFGWK----DEDDLDRVLKTGVC--LISQDYGYTIFSTV--- 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      198 VTYLAPLGLMAMAYFQIFRKlwgrqipgttsaevkqMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRvfgmFRQASDR 277
Cdd:cd15331 168 GAFYVPLLLMIIIYWKIYQA----------------AKRERKAARTLAIITGAFVVCWLPFFLVALVMP----FCGAWQI 227
                       250       260       270
                ....*....|....*....|....*....|....*.
6TO7_B      278 EAVYAAFTFshWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15331 228 SRFLESFFL--WLGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
38-313 6.05e-19

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 85.34  E-value: 6.05e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       38 VGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15977  16 IGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILIAIPINVIKLIAEDWPFGVHVCKLYPFIQKASVGITVLSLCALS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKSTA---RRALGSILgIWAVSLAIMVPQAAVMEcssvLPELAARTRAFSVC---DERWADDLapKIY 191
Cdd:cd15977  96 IDRYRAVASWSRIRGIGipvWKAVEVTL-IWAVAIIVAVPEAIAFD----MVEIDYRGQTLLVCmlpMEQTSSFM--RFY 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      192 HSC----FFIVTYLAPLGLMAMAYFQIFRKLWGRQiPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRV 267
Cdd:cd15977 169 QDVkdwwLFGFYFCLPLACTGVFYTLMSCEMLSIK-NGMRIALNDHMKQRREVAKTVFCLVVIFALCWLPLHLSRILKKT 247
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
6TO7_B      268 FGMFRQASDREAVYAAFTFSHW---LVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15977 248 IYDVKDPQRCELLSFLLVMDYTginMASLNSCINPVALYFVSRKFKNCF 296
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
39-313 1.44e-18

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 83.87  E-value: 1.44e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15330  17 GNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIAL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPqaavmecssvlPELAARTRAFSVCDE--RWADDLAPKIYHS- 193
Cdd:cd15330  97 DRYWAITDPIDYvnKRTPRRAAVLISLTWLIGFSISIP-----------PMLGWRTPEDRSDPDacTISKDPGYTIYSTf 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 -CFFIvtylaPLGLMAMAYFQIFrklwgrqipgttsaevKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLkrvfgMFR 272
Cdd:cd15330 166 gAFYI-----PLILMLVLYGRIF----------------KAAARERKTVKTLGIIMGTFILCWLPFFIVALV-----LPF 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
6TO7_B      273 QASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15330 220 CESTCHMPELLGAIINWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
39-302 2.04e-18

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 84.14  E-value: 2.04e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15957  17 GNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVS-LAIMVPqaAVMECSSVLPELAARTRAfsvcDERWADDLAPKIYHSCF 195
Cdd:cd15957  97 DRYFAITSPFKYQSllTKNKARVIILMVWIVSgLTSFLP--IQMHWYRATHQEAINCYA----EETCCDFFTNQAYAIAS 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAY----------FQIFRKLWGR----QIPGTTSAEVKQMRAR-------RKTAKMLMVVVLVFALC 254
Cdd:cd15957 171 SIVSFYVPLVIMVFVYsrvfqeakrqLQKIDKSEGRfhnqNIDQNGSGGGGGNRRRskfclkeHKALKTLGIIMGTFTLC 250
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
6TO7_B      255 YLPISVLNVLKRVfgmfrqaSDREAVYAAFTFSHWLVYANSAANPIIY 302
Cdd:cd15957 251 WLPFFIVNIVHVI-------QDNLIRKEVYILLNWIGYVNSGFNPLIY 291
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
39-313 2.24e-18

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 83.91  E-value: 2.24e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAIC-LPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15337  17 GNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNgFPLKTISSFNKKWIWGKVACELYGFAGGIFGFMSITTLAAIS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPL--LFKSTARRALGSILGIWAVSLAIMVPqaAVMECSSVLPELAARTRAFsvcdERWADDLAPKIYHSCF 195
Cdd:cd15337  97 IDRYLVIAKPLeaMKKMTFKRAFIMIIIIWLWSLLWSIP--PFFGWGRYVPEGFQTSCTF----DYLSRDLNNRLFILGL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKLWG----------RQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNvlk 265
Cdd:cd15337 171 FIFGFLCPLLIIIFCYVNIIRAVRNhekemtqtakSGMGKDTEKNDARKKAEIRIAKVAIILISLFLLSWTPYAVVA--- 247
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
6TO7_B      266 rVFGMFRQAsdreavyaaftfsHWL---------VYANSAA--NPIIYNFLSGKFREQF 313
Cdd:cd15337 248 -LLGQFGPA-------------YWItpyvselpvMFAKASAiyNPIIYALSHPKFRAAL 292
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
39-310 2.39e-18

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 83.90  E-value: 2.39e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRN-HHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15382  17 GNLTVLLILLRNrRRKRSRVNILLMHLAIADLLVTFIMMPLEIGWAATVAWLAGDFLCRLMLFFRAFGLYLSSFVLVCIS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSvlpelAARTRAFSVC--DERWADDLAPKIYHSCF 195
Cdd:cd15382  97 LDRYFAILKPLRLSDARRRGRIMLAVAWVISFLCSIPQSFIFHVES-----HPCVTWFSQCvtFNFFPSHDHELAYNIFN 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAY----FQIFRKlwGRQIPGTTSAEVKQM-----------RARRKTAKMLMVVVLVFALCYLPISV 260
Cdd:cd15382 172 MITMYALPLIIIVFCYslilCEISRK--SKEKKEDVSEKSSSVrlrrssvglleRARSRTLKMTIVIVLVFIICWTPYFI 249
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
6TO7_B      261 LNVLKrvfgMFRQAS----DREAVYAAFTFShwlvYANSAANPIIYNFLSGKFR 310
Cdd:cd15382 250 MSLWY----WFDRESaskvDPRIQKGLFLFA----VSNSCMNPIVYGYFSIDLR 295
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
39-317 3.50e-18

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 82.95  E-value: 3.50e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15295  17 GNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVIDYLLCTASVYNIVLISY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFK---STARRALGSILGIWAvsLAIMVPQAAVMECSSVLPELaartrafSVCDERWaddLAPKIYHSCF 195
Cdd:cd15295  97 DRYQSVSNAVSYRnqqTATLRIVTQMVAVWV--LAFLVHGPAILVSDSWKTED-------GECEPEF---FSNWYILAIT 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsaevKQMRArRKTAKMLMVVVLVFALCYLPISvlnvlkrVFGMFRQAS 275
Cdd:cd15295 165 SVLEFLVPVILVAYFNTQIYWSLW------------KRLRD-RKLAKSLAIILGTFAICWAPYS-------LFTIIRAAC 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
6TO7_B      276 DREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAF 317
Cdd:cd15295 225 EKHRGSPWYNFAFWLQWFNSFINPFLYPLCHKRFRKAFLKIF 266
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
39-313 4.41e-18

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 83.33  E-value: 4.41e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15385  17 GNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFQVLPQLCWDITYRFYGPDFLCRIVKHLQVLGMFASTYMLVMMTA 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPL-LFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARtrafsvcdERWADDLAP---KIYHSC 194
Cdd:cd15385  97 DRYIAICHPLkTLQQPTKRSYLMIGSAWALSFILSTPQYFIFSLSEIENGSGVY--------DCWANFIVPwgiKAYITW 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVTYLAPLGLMAMAYFQIFRKLWgRQIPGTTS-----------------AEVKQM-RARRKTAKMLMVVVLVFALCYL 256
Cdd:cd15385 169 ITISIFVVPVIILLTCYGFICYNIW-RNIKCKTRrglsdnalknillavcvSSVKTIsRAKIRTVKMTFVIVLAYIVCWA 247
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
6TO7_B      257 PISVLNVLKRVFGMFrqaSDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15385 248 PFFTIQMWSVWDQNF---PWDESENTAVTITALLASLNSCCNPWIYMFFSGHLLQDF 301
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
39-313 6.42e-18

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 82.42  E-value: 6.42e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNH-----HMRTVtnyfLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTL 113
Cdd:cd15383  17 SNLAVLWSATRNRrrklsHVRIL----ILHLAAADLLVTFVVMPLDAAWNVTVQWYAGDLACRLLMFLKLFAMYSSAFVT 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      114 SFIALDRWYAICHPLLFKStARRALGSILGI-WAVSLAIMVPQAAVMECSSVLPELaartrAFSVC------DERWADdl 186
Cdd:cd15383  93 VVISLDRHAAILNPLAIGS-ARRRNRIMLCAaWGLSALLALPQLFLFHTVTATPPV-----NFTQCathgsfPAHWQE-- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      187 apKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLwGRQIPGTTSAEVKQM----------RARRKTAKMLMVVVLVFALCYL 256
Cdd:cd15383 165 --TLYNMFTFFCLFLLPLLIMIFCYTRILLEI-SRRMKEKKDSAKNEValrsssdnipKARMRTLKMTIVIVSSFIVCWT 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
6TO7_B      257 PISVLNVLKRVF-GMFRQASDREAVYAAFTFShwlvYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15383 242 PYYLLGLWYWFSpEMLEQTVPESLSHILFLFG----LLNACLDPLIYGLFTISFRRGL 295
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
39-313 7.02e-18

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 82.13  E-value: 7.02e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFghALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15070  17 GNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSLGVTIHF--YSCLFMSCLLVVFTHASIMSLLAIAV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFK--STARRALGSILGIWAVSLAI-MVPqaavMECSSVLPELAARTRAFSVCDERWADDLAPKIYHScf 195
Cdd:cd15070  95 DRYLRVKLTVRYRivTTQRRIWLALGLCWLVSFLVgLTP----MFGWNRKPSLESVNTTPLQCQFTSVMRMDYMVYFS-- 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQMRARR--KTAKMLMVVVLVFALCYLPISVLNVLKrvfgMFRQ 273
Cdd:cd15070 169 FFTWILIPLVIMCALYVDIFYIIRNKLSQNATGFRETGAFYGRefKTAKSLALVLFLFAVCWLPLSIINCVV----YFNP 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
6TO7_B      274 ASDREAVYAAFTFSHwlvyANSAANPIIYNFLSGKFREQF 313
Cdd:cd15070 245 KVPKIALYLGILLSH----ANSMMNPIVYACKIKKFKETY 280
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
40-317 7.26e-18

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 81.77  E-value: 7.26e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 119
Cdd:cd15333  22 NAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLSSDITCCTASILHLCVIALD 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      120 RWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVP-----QAAVMEcssVLPELAARTrafsvcderwaDDLAPKIYH 192
Cdd:cd15333 102 RYWAITDAVEYskKRTPKRAAVMIALVWVISISISLPpffwrQAKAEE---EVSECVVNT-----------DHILYTVYS 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      193 SC--FFIvtylaPLGLMAMAYFQIFRklwgrqipgttsaevkQMRAR-RKTAKMLMVVVLVFALCYLPISVLNVLKRVFg 269
Cdd:cd15333 168 TVgaFYI-----PTLLLIALYGRIYV----------------EARAReRKATKTLGIILGAFIVCWLPFFIISLVLPIC- 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
6TO7_B      270 mfrqasdREAVY---AAFTFSHWLVYANSAANPIIYNFlsgkFREQFKAAF 317
Cdd:cd15333 226 -------KDACWfhlAIFDFFTWLGYLNSLINPIIYTM----SNEDFKQAF 265
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
39-313 1.03e-17

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 81.52  E-value: 1.03e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITE-SWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15304  17 GNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGyRWPLPSKLCAVWIYLDVLFSTASIMHLCAIS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFK--STARRALGSILGIWAVSLAIMVPqaavmecssvLPELAARTrafsvcDERWADDLAPKIYHSCF 195
Cdd:cd15304  97 LDRYIAIRNPIHHSrfNSRTKAFLKIIAVWTISVGISMP----------IPVFGLQD------DSKVFKEGSCLLADENF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FI----VTYLAPLGLMAMAYFQIFRKLWgrqipgttsaevKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVfgmF 271
Cdd:cd15304 161 VLigsfVAFFIPLTIMVITYFLTIKSLQ------------QSISNEQKASKVLGIVFFLFVVMWCPFFITNVMAVI---C 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
6TO7_B      272 RQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15304 226 KESCNEVVIGGLLNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
45-313 1.18e-17

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 81.38  E-value: 1.18e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       45 LAVWRNHhmrtvtNYFLVNLSLADVLaTAICLPASLLVDIT-ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYA 123
Cdd:cd15199  29 LKVWKPY------AVYLLNLVLADVL-LLICLPFKAYFYLNgNRWSLGGGTCKALLFMLSLSRGVSIAFLTAVALDRYFR 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      124 ICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVMEcssvlPELAARTRAFSvcdeRWADDLAPKIYHSCFFIVTYL 201
Cdd:cd15199 102 VVHPRGKKNslSLQAAPYISFLVWLLLVGLTIPTLLASQ-----PKNFTECNSFS----PKDDEDFSDTWQEAVFFLQFL 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      202 APLGLMAMAYFQIFRKLWGRqipgtTSAEVKQMRARRKTAkMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASDREAVY 281
Cdd:cd15199 173 LPFGLIVFCTVRIIRRLKKR-----LRDVGKQPKLQRAMA-LVTSVVVVFGFCFLPCFLARVLMLIFQNKESCNALNIAV 246
                       250       260       270
                ....*....|....*....|....*....|..
6TO7_B      282 AAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15199 247 HTYDVTMCLTYLNSVLDPIVYCFSSPTFRSSY 278
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
39-313 1.73e-17

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 80.65  E-value: 1.73e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15308  17 GNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYSEFQGGvWTLSPVLCDALMTMDVMLCTASIFNLCAIS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPqaAVMECSSVlpelaaRTRAFSVCDerwADDLAPKIYHScf 195
Cdd:cd15308  97 VDRFIAVSVPLNYnrRQGSVRQLLLISATWILSFAVASP--VIFGLNNV------PNRDPAVCK---LEDNNYVVYSS-- 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 fIVTYLAPLGLMAMAYFQIFRKLwGRQipgttsaevkqmrarRKTAKMLMVVVLVFALCYLPISVLNVLKrvfGMFRQAS 275
Cdd:cd15308 164 -VCSFFIPCPVMLVLYCAMFRGL-GRE---------------RKAMRVLPVVVGAFLFCWTPFFVVHITR---ALCESCS 223
                       250       260       270
                ....*....|....*....|....*....|....*...
6TO7_B      276 DREAVYAAFTfshWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15308 224 IPPQLISIVT---WLGYVNSALNPVIYTVFNAEFRNVF 258
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
39-309 1.76e-17

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 81.38  E-value: 1.76e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15386  17 GNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFQVLPQLIWEITYRFQGPDLLCRAVKYLQVLSMFASTYMLIMMTV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPL-LFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPElaartrafSVCDERWAD---DLAPKIYHSC 194
Cdd:cd15386  97 DRYIAVCHPLrTLQQPSRQAYLMIGATWLLSCILSLPQVFIFSLREVDQG--------SGVLDCWADfgfPWGAKAYITW 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVTYLAPLGLMAMAY----FQIFRKL-------------WGRQIPGTTSAEVKQM-RARRKTAKMLMVVVLVFALCYL 256
Cdd:cd15386 169 TTLSIFVLPVAILIVCYslicYEICKNLkgktqtsrsegggWRTQGMPSRVSSVRTIsRAKIRTVKMTFVIVLAYIACWA 248
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
6TO7_B      257 PI------SVLNVlkrvfgmfrQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKF 309
Cdd:cd15386 249 PFfsvqmwSVWDE---------NAPDEDSSDFAFTITMLLASLSSCCNPWIYMFFSGHL 298
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
39-313 2.00e-17

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 81.05  E-value: 2.00e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLqaVSVSVAVLTLSFIAL 118
Cdd:cd15071  17 GNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQTEFYSCLMVACPVL--ILTQSSILALLAIAV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAI-MVPQAAVMECSSVLPELAARTRAFSVCDERWADDLAPKIYHSCF 195
Cdd:cd15071  95 DRYLRVKIPTRYKSvvTPRRAAVAIAGCWILSFLVgLTPMFGWNNLNAVERAWAANSSMGELVIKCQFETVISMEYMVYF 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 -FIVTYLAPLGLMAMAYFQIF---RKLWGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMF 271
Cdd:cd15071 175 nFFVWVLPPLLLMLLIYLEVFyliRKQLNKKVSSSSSDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSC 254
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
6TO7_B      272 RQASdrEAVYAAFTFSHwlvyANSAANPIIYNFLSGKFREQF 313
Cdd:cd15071 255 KKPM--ILTYIAIFLTH----GNSAMNPIVYAFRIKKFRTTF 290
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
39-270 2.47e-17

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 80.69  E-value: 2.47e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITES---WLFGHALCKVIPYLQAVSVSVAVLTLSF 115
Cdd:cd15006  16 GNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFDIVLSASPHccwWIYTLLFCKVIKFLHKVFCSVTVLSFAA 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      116 IALDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLpelaartrAFSVCDERWADDLAPKIYHSCF 195
Cdd:cd15006  96 IALDRYYSVLYPLERKISDAKSRDLVIYIWAHAVVASVPVFAVTNVTDIY--------AMSTCTESWGYSLGHLVYVIIY 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQMR-------ARRKTAK---MLMVVVLVFALCYLPISVLNVLK 265
Cdd:cd15006 168 NITTVILPVAVVFLFMILIRRALSASQKKKVIIAALRTPQntisipyVSQREAElhaMLLSMVLVFILCSVPYATLVIYR 247

                ....*
6TO7_B      266 RVFGM 270
Cdd:cd15006 248 TILNI 252
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
39-313 3.71e-17

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 80.34  E-value: 3.71e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15401  17 GNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGLSVIGSVFNITAIAI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVMECsSVLPELAARTRAFSVCDErwaddlapkiYHSCFF 196
Cdd:cd15401  97 NRYCYICHSLRYDKlyNMKKTCCYVCLTWVLTLAAIVPNFFVGSL-QYDPRIYSCTFAQTVSSS----------YTITVV 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFrkLWGRQIPGTTSAEVKQ-MRARRKTAKMLMVVVLV-FALCYLPISVLNVLKRVFGMFRQA 274
Cdd:cd15401 166 VVHFIVPLSIVTFCYLRIW--VLVIQVKHRVRQDSKQkLKANDIRNFLTMFVVFVlFAVCWGPLNFIGLAVAINPLKVAP 243
                       250       260       270
                ....*....|....*....|....*....|....*....
6TO7_B      275 SDREAVyaaFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15401 244 KIPEWL---FVLSYFMAYFNSCLNAVIYGVLNQNFRKEY 279
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
40-317 3.87e-17

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 79.58  E-value: 3.87e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 119
Cdd:cd15335  18 NSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDMTCCTCSILHLCVIALD 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      120 RWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTRafsvcderwADDLAPKIYHSC--F 195
Cdd:cd15335  98 RYWAITDAIEYarKRTAKRAGLMILTVWTISIFISIPPLFWRNHHDANIPSQCIIQ---------HDHVIYTIYSTFgaF 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIvtylaPLGLMAMAYFQIFrklwgrqipgttSAEVKQmrarRKTAKMLMVVVLVFALCYLP--ISVLNVLKRVFGMFRQ 273
Cdd:cd15335 169 YI-----PLTLILILYYRIY------------HAASRE----RKAARILGLILGAFILSWLPffIKELIVGLSVMTVSPE 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
6TO7_B      274 ASDreavyaaftFSHWLVYANSAANPIIYNflsgKFREQFKAAF 317
Cdd:cd15335 228 VAD---------FLTWLGYVNSLVNPLLYT----SFNEDFKLAF 258
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
39-313 6.02e-17

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 79.24  E-value: 6.02e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd17790  17 GNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASVMNLLIISF 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPqaAVMECSSVLPElaaRTRAFSVCDERWaddLAPKIYHSCFF 196
Cdd:cd17790  97 DRYFSITRPLTYraKRTPRRAAIMIGLAWLISFVLWAP--AILFWQYLVGE---RTVLAGQCYIQF---LSQPIITFGTA 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKlwgrqipgttsaEVKQmrarRKTAKMLMVVVLVFALCYLPISVLNVLKrvfgMFRQASD 276
Cdd:cd17790 169 IAAFYLPVTIMIILYWRIYRE------------TIKE----KKAARTLSAILLAFILTWTPYNIMVLVS----TFCKDCV 228
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      277 REAVYaafTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd17790 229 PKTLW---ELGYWLCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
39-313 6.25e-17

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 79.44  E-value: 6.25e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15209  17 GNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGLSVIGSIFNITAIAI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAimvpqaavmecsSVLPELAARTRAFSvcderwaddlaPKIYhSCFF 196
Cdd:cd15209  97 NRYCYICHSLQYDRlySLRNTCCYLCLTWLLTVL------------AVLPNFFIGSLQYD-----------PRIY-SCTF 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVT-------------YLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNV 263
Cdd:cd15209 153 AQTvstvytitvvvihFLLPLLIVSFCYLRIWVLVLQVRQRVKPDQRPKLKPADVRNFLTMFVVFVLFAVCWAPLNFIGL 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
6TO7_B      264 LKRVFGMFRQASDREAVYAAftfSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15209 233 AVAINPKEMAPKIPEWLFVA---SYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-307 7.65e-17

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 79.48  E-value: 7.65e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15387  17 GNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFQVLPQLIWDITFRFYGPDFLCRLVKYLQVVGMFASTYMLLLMSI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLlfKSTARRA-LGSILGIWAVSLAIMVPQAAVMECSSVLPELAartrafsvcdERWADDLAP---KIYHSC 194
Cdd:cd15387  97 DRCLAICQPL--RSLHRRSdRVYVLFSWLLSLVFSIPQVHIFSLREVGNGVY----------DCWADFIQPwgpKAYITW 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVTYLAPLGLMAMAYFQIFRKLW---------GRQIPGTTSAEVKQM-----------RARRKTAKMLMVVVLVFALC 254
Cdd:cd15387 165 ITLSVYIIPVLILSVCYGLISFKIWqnvklktrrETKTPLSSAASGGAAlarvssvklisKAKIRTVKMTFVIVLAYIVC 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
6TO7_B      255 YLPISVLnvlkRVFGMFRQASDREAvyAAFTFSHWLVYANSAANPIIYNFLSG 307
Cdd:cd15387 245 WTPFFFV----QMWSVWDPNAPKEA--SPFIIAMLLASLNSCCNPWIYMFFTG 291
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
40-313 7.99e-17

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 79.26  E-value: 7.99e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDItESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 119
Cdd:cd14972  16 NSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLL-VSLTPSPATWLLRKGSLVLSLLASAYSLLAIAVD 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      120 RWYAICHPLLFKS--TARRALGSILGIWAVSLAI-MVP-------QAAVMECSSVLPELaarTRAFSVcderwaddlapk 189
Cdd:cd14972  95 RYISIVHGLTYVNnvTNKRVKVLIALVWVWSVLLaLLPvlgwncvLCDQESCSPLGPGL---PKSYLV------------ 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      190 iyhscFFIVTYLAPLGLMAMAYFQIFRKLW---GRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKR 266
Cdd:cd14972 160 -----LILVFFFIALVIIVFLYVRIFWCLWrhaNAIAARQEAAVPAQPSTSRKLAKTVVIVLGVFLVCWLPLLILLVLDV 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
6TO7_B      267 VFGMFRQasdreaVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd14972 235 LCPSVCD------IQAVFYYFLVLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
40-311 9.10e-17

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 79.07  E-value: 9.10e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCkvipYLQAVSVS----VAVLTLSF 115
Cdd:cd15082  31 NFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFLGVWAC----VLEGFAVTffgiVALWSLAV 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      116 IALDRWYAICHPL-LFKSTARRALGSILGIWAVSLAIMVPqaAVMECSSVLPELAARTrafsvCDERW-ADDLAPKIYHS 193
Cdd:cd15082 107 LAFERFFVICRPLgNIRLQGKHAALGLLFVWTFSFIWTIP--PVLGWSSYTVSKIGTT-----CEPNWySGNMHDHTYII 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 CFFIVTYLAPLGLMAMAYFQIFRKLwgRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFrQ 273
Cdd:cd15082 180 TFFTTCFILPLGVIFVSYGKLLQKL--RKVSNTQGRLGNARKPERQVTRMVVVMIVAFMVCWTPYAAFSILVTAHPTI-H 256
                       250       260       270
                ....*....|....*....|....*....|....*...
6TO7_B      274 ASDREAVYAAFTFSHWLVYansaaNPIIYNFLSGKFRE 311
Cdd:cd15082 257 LDPRLAAIPAFFSKTAAVY-----NPIIYVFMNKQFRK 289
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
39-304 1.10e-16

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 79.08  E-value: 1.10e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAI-CLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15198  17 GNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGtALSQIIWELLGDRWMAGDVACRLLKLLQASARGASANLVVLLA 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPL--LFKSTARRALGsilgiWAVSLAIMVPQAAVMECSSVlPELAARTRAFSVCDERWADDLA--PKIYHS 193
Cdd:cd15198  97 LDRHQAIRAPLgqPLRAWKLAALG-----WLLALLLALPQAYVFRVDFP-DDPASAWPGHTLCRGIFAPLPRwhLQVYAT 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 CFFIVTYLAPLGLMAMAYFQIFRKLW---------------GRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPI 258
Cdd:cd15198 171 YEAVVGFVAPVVILGVCYGRLLLKWWeranqapgakkpwkkPSKSHLRATAPSALPRAKVKTLKMTLVIALLFVGCSLPY 250
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
6TO7_B      259 SVLNvLKRVFGMFRQasDREAVYAAFTFshwLVYANSAANPIIYNF 304
Cdd:cd15198 251 FIAE-LAAAFGSGDW--EPEKVAAALGV---MAVANSATNPFVFLF 290
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
39-313 1.11e-16

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 78.79  E-value: 1.11e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITE-SWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15305  17 GNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDyAWPLPRYLCPIWISLDVLFSTASIMHLCAIS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFK--STARRALGSILGIWAVSLAIMVPQAAVmecssvlpELAARTRAF--SVCderwadDLAPKIYHS 193
Cdd:cd15305  97 LDRYVAIRNPIEHSrfNSRTKAMMKIAAVWTISIGISMPIPVI--------GLQDDEKVFvnGTC------VLNDENFVL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 CFFIVTYLAPLGLMAMAYFQIFRKLWGRQipgttsaevkQMRARRKTAKMLMVVVLVFALCYLPISVLNVLkrvFGMFRQ 273
Cdd:cd15305 163 IGSFVAFFIPLIIMVITYCLTIQVLQRQQ----------AINNERRASKVLGIVFFLFLIMWCPFFITNIL---SVLCKE 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
6TO7_B      274 ASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15305 230 ACDQKLMEELLNVFVWVGYVSSGINPLVYTLFNKTYRRAF 269
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
39-313 1.17e-16

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 78.66  E-value: 1.17e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLatAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15173  17 GNSLVIVIYIFYEKLRTLTDIFLVNLAVADLL--FLCTLPFWAYSAAHEWIFGTVMCKITNGLYTINLYSSMLILTCITV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSI--LGIWAVSLAIMVPQAAVMEcssvlpelaARTRAFSVCDERWADDLAPKIYHSC 194
Cdd:cd15173  95 DRFIVIVQATKAHNchAKKMRWGKVvcTLVWVISLLLSLPQFIYSE---------VRNLSSKICSMVYPPDAIEVVVNII 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVTYLAPLGLMAMAYFQIFRKLwgrqipgtTSAEVKQmraRRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFrqa 274
Cdd:cd15173 166 QMTVGFFLPLLAMIICYSVIIKTL--------LHAKGFQ---KHKSLKIIFVVVAVFILTQLPYNIMKLIRTLHIEN--- 231
                       250       260       270
                ....*....|....*....|....*....|....*....
6TO7_B      275 SDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15173 232 TDSTNFKYAILITEAIAYLHACLNPILYAFVGVKFRKNF 270
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
39-313 1.66e-16

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 78.41  E-value: 1.66e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15402  17 GNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGLSVIGSIFNITGIAI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVMECsSVLPELAARTRAFSVCDerwADDLAPKIYHscff 196
Cdd:cd15402  97 NRYCYICHSLKYDKlySDKNSLCYVLLIWVLTVAAIVPNLFVGSL-QYDPRIYSCTFAQSVSS---AYTIAVVFFH---- 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 ivtYLAPLGLMAMAYFQIF-------RKLWGRQIPGTTSAEVkqmrarRKTAKMLMVVVLvFALCYLPISVLNVlkrvfg 269
Cdd:cd15402 169 ---FILPIIIVTFCYLRIWilviqvrRRVKPDNKPKLKPHDF------RNFVTMFVVFVL-FAVCWAPLNFIGL------ 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
6TO7_B      270 mfRQASDREAVYAA-----FTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15402 233 --AVAVDPETIVPRipewlFVASYYMAYFNSCLNAIIYGLLNQNFRREY 279
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
39-307 1.80e-16

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 78.29  E-value: 1.80e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADvLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd14975  17 GNSFVIWSILIKVKQRSVTMLLVLNLALAD-LAVLLTLPVWIYFLATGTWDFGLAACKGCVYVCAVSMYASVFLITLMSL 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRAL--GSILGIWAVSLAIMVPQAAVMEcssvlpelAARTRAFSVCDERWADDlAPKIYHSCF- 195
Cdd:cd14975  96 ERFLAVSRPFVSQGWRAKALahKVLAIIWLLAVLLATPVIAFRH--------VEETVENGMCKYRHYSD-GQLVFHLLLe 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKLWGRqipgttsaevkQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVF----GMF 271
Cdd:cd14975 167 TVVGFAVPFTAVVLCYSCLLRRLRRR-----------RFRRRRRTGRLIASVVVAFAACWLPYHVGNLLEVVSeligGSK 235
                       250       260       270
                ....*....|....*....|....*....|....*.
6TO7_B      272 RQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSG 307
Cdd:cd14975 236 MAGTLGKVAEAGRPIAGALAFLSSSINPLLYAFAAR 271
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
39-311 2.36e-16

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 78.35  E-value: 2.36e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15403  17 GNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLYWFFVLEGVAILLIISV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPlLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVlPELAARtrafsvCDERWADDLAPKIYHSCFFIV 198
Cdd:cd15403  97 DRFLIIVQR-QDKLNPHRAKVMIAISWVLSFCISFPSVVGWTLVEV-PARAPQ------CVLGYTESPADRVYAVLLVVA 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      199 TYLAPLGLMAMAYFQIFR------------------------KLWGRQIPGTTSAEvkqMRARRKTAKMLMVVVLVFALC 254
Cdd:cd15403 169 VFFVPFSIMLYSYLCILNtvrrnavrihnhadslclsqvsklGLMGLQRPHQMNVD---MSFKTRAFTTILILFVGFSLC 245
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
6TO7_B      255 YLPISVLNVLKrVFGmfRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15403 246 WLPHTVFSLLS-VFS--RRFYYSSSFYPISTCVLWLSYLKSVFNPVIYCWRIKKFRE 299
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
60-313 3.86e-16

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 77.10  E-value: 3.86e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       60 FLVNLSLADVLaTAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPL--LFKSTARR 136
Cdd:cd15162  38 YMANLAIADLL-LVIWLPFKIAYHIHGNnWIFGEALCRLVTVAFYGNMYCSILLLTCISIDRYLAIVHPMghRRLRARRY 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      137 ALGSILGIWAVSLAIMVP-----------QAAVMECSSVLPElaartrafsvcDERWADDLApkiYHSCFFIVTYLAPLG 205
Cdd:cd15162 117 ALGTCLAIWLLALLVTLPlylvkqtiflpALDITTCHDVLPE-----------QLLVGDWFY---YFLSLAIVGFLIPFI 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      206 LMAMAYFQIFRKLwgrqipgtTSAEVKQMRARRKTAKMLMVVVL-VFALCYLPIsvlNVLKRVFGMFRQASDREAVYAAF 284
Cdd:cd15162 183 LTASCYVATIRTL--------AALEDENSEKKKKRAIKLAATVLaIFIICFAPS---NLLLLAHYSLISSSGTGHLYFAY 251
                       250       260
                ....*....|....*....|....*....
6TO7_B      285 TFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15162 252 LLALCLSTLNSCIDPFIYYFVSKEFRDHV 280
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
40-317 3.93e-16

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 76.91  E-value: 3.93e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 119
Cdd:cd15334  18 NSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDITCCTCSILHLSAIALD 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      120 RWYAICHPLLF--KSTARRALGSILGIWAVSLAIMvpqaavmecssvLPELAARTRAFSVCDERWA--DDLAPKIYHS-- 193
Cdd:cd15334  98 RYRAITDAVEYarKRTPKHAGIMIAVVWIISIFIS------------MPPLFWRHQTTSREDECIIkhDHIVFTIYSTfg 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 CFFIvtylaPLGLMAMAYFQIFRklwgrqipgttsAEVKQmrarRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQ 273
Cdd:cd15334 166 AFYI-----PLALILILYYKIYR------------AATRE----RKAATTLGLILGAFVICWLPFFVKEVIVNTCDSCYI 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
6TO7_B      274 ASDREavyaafTFSHWLVYANSAANPIIYNFlsgkFREQFKAAF 317
Cdd:cd15334 225 SEEMS------NFLTWLGYINSLINPLIYTI----FNEDFKKAF 258
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
39-313 5.19e-16

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 77.16  E-value: 5.19e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTV--TNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 116
Cdd:cd14976  17 GNLLVLYLLKSNKKLRQQseSNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRYVTKLNMYSSIFFLTAL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      117 ALDRWYAICHPLlfksTARRALGSiLGIWAVSLAIMVPQAAVMECSSVLPELAARTRAFSVCDERWADDLAPK------- 189
Cdd:cd14976  97 SVTRYIAVARAL----KHGWIRKA-FGAFATTIAIWAAAALAAIPEAIFSTDTWSSVNHTLCLLRFPKNSSVTrwynwlg 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      190 IYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTtsaevkqmRARRKTAKMLMVVVLVFALCYLPISVLNvLKRVFG 269
Cdd:cd14976 172 MYQLQKVVLGFFLPLGIITLSYLLLLRFLQRKRGGSK--------RRKSRVTKSVFIVVLSFFICWLPNQALS-LWSALI 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
6TO7_B      270 MFRQASDREAVYAAFTF----SHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd14976 243 KFDDVPFSDAFFAFQTYafpvAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
39-310 5.73e-16

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 76.71  E-value: 5.73e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLaTAICLP---ASLLVDitESWLFGHALCKVIPYLQAVSVSVAVLTLSF 115
Cdd:cd15193  17 GNLFVIALMSKRSTTKRLVDTFVLNLAVADLV-FVLTLPfwaASTALG--GQWLFGEGLCKLSSFIIAVNRCSSILFLTG 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      116 IALDRWYAICHPLLFK--STARRALGSILGIWAVSLAIMVPQAAVMecssvlpelaaRTRAFSVCDERWADDLAPKIYHS 193
Cdd:cd15193  94 MSVDRYLAVVKLLDSRplRTRRCALITCCIIWAVSLVLGIPSLVYR-----------NLINESVCVEDSSSRFFQGISLA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 CFFIvTYLAPLGLMAMAYFQIFRKLWGRQIPGTtsaevKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVF--GMF 271
Cdd:cd15193 163 TLFL-TFVLPLIVILFCYCSILVRLRRHFHGAK-----RTGRRRRNSLRIVFAIVTAFVLSWLPFNTLKAVRLLLelGGG 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
6TO7_B      272 RQASDRE-AVYAAFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15193 237 VLPCHTTvAIRQGLTITACLAFVNSCVNPLIYSLLDRHFR 276
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
39-314 6.65e-16

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 76.53  E-value: 6.65e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15299  20 GNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISF 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRAlGSILGI-WAVSLAIMVPQAAVMECSsvlpeLAARTRAfsvCDERWADDLAPKIYHSCF 195
Cdd:cd15299 100 DRYFSITRPLTYraKRTTKRA-GVMIGLaWVISFVLWAPAILFWQYF-----VGKRTVP---PDECFIQFLSEPIITFGT 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKlwgrqipgttsaEVKQmrarRKTAKMLMVVVLVFALCYLPISVLnVLKRVFgmfrqaS 275
Cdd:cd15299 171 AIAAFYLPVTIMTILYWRIYKE------------TIKE----KKAAQTLSAILLAFIITWTPYNIM-VLVNTF------C 227
                       250       260       270
                ....*....|....*....|....*....|....*....
6TO7_B      276 DREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFK 314
Cdd:cd15299 228 DSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFK 266
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
39-313 8.12e-16

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 76.40  E-value: 8.12e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15301  17 GNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASNASVLNLLIISF 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPQAAVMecssvlPELAARtraFSV-CDERWADDLAPKIYHSC- 194
Cdd:cd15301  97 DRYFSVTRPLTYraRRTTKKAAVMIASAWIISLLLWPPWIYSW------PYIEGK---RTVpAGTCYIQFLETNPYVTFg 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVTYLAPLGLMAMAYFQIFRKlwgrqipgttsAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFgmfrqA 274
Cdd:cd15301 168 TALAAFYVPVTIMCILYWRIWRE-----------TKKRQKKQESKAAKTLSAILLAFIVTWTPYNVLVLIKAFF-----P 231
                       250       260       270
                ....*....|....*....|....*....|....*....
6TO7_B      275 SDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15301 232 CSDTIPTELWDFSYYLCYINSTINPLCYALCNAAFRRTY 270
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
39-313 8.76e-16

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 76.33  E-value: 8.76e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15191  17 GNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGYNWLFGSVMCKICGSLLTLNLFASIFFITCMSV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF-KSTARRALGSILGIWAVSLAIMVPqAAVMECSSVLPELAARTRAFSVCDER---WADDLA-PKIyhs 193
Cdd:cd15191  97 DRYLAVVYPLRSqRRRSWQARLVCLLVWVLACLSSLP-TFYFRDTYYIEELGVNACIMAFPNEKyaqWSAGLAlMKN--- 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 cffIVTYLAPLGLMAMAYFQIFRKLWGRQIPGttsaevKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLK--RVFGMF 271
Cdd:cd15191 173 ---TLGFLIPLIVIATCYFGIGRHLLKTKGFG------KNKQRRDKVLKMVAAVVLAFLICWFPFHVLTFLDalARMGVI 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
6TO7_B      272 RQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15191 244 NNCWVITVIDKALPFAICLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
39-313 9.75e-16

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 76.04  E-value: 9.75e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15400  17 GNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSIFNITGIAI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVmecssvlPELAARTRAFSVCDERwaddLAPKIYHSCFF 196
Cdd:cd15400  97 NRYCYICHSFAYDKlySRWNTLLYVCLIWALTVVAIVPNFFV-------GSLEYDPRIYSCTFVQ----TASSSYTIAVV 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKLWG--RQIPGTTSAEVKQMRARRKTAkmLMVVVLVFALCYLPisvLNVLKRVFGMFRQA 274
Cdd:cd15400 166 VIHFIVPITVVSFCYLRIWVLVIQvrRKVKSESKPRLKPSDFRNFLT--MFVVFVIFAICWAP---LNLIGLAVAINPQE 240
                       250       260       270
                ....*....|....*....|....*....|....*....
6TO7_B      275 SDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15400 241 MAPKVPEWLFVVSYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
51-313 1.06e-15

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 76.06  E-value: 1.06e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       51 HHMRTVTNYFLVNLSLADVLATAICLPASL--LVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPL 128
Cdd:cd15356  32 RGLQGTVHYHLVSLALSDLLILLISVPIELynFVWFHYPWVFGDLVCRGYYFVRDICSYATVLNIASLSAERYLAICQPL 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      129 LFKS--TARRALGSILGIWAVSLAIMVPQAAVM------ECSSVLPELAARtrafsVCDErWADDLAPKIYHSCFFIVTY 200
Cdd:cd15356 112 RAKRllSKRRTKWLLALIWASSLGFALPMAFIMgqkyelETADGEPEPSSR-----VCTV-LVSRATLKVFIQVNAFVSF 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      201 LAPLGLMAMAYFQIFRKLwgrqipgttsaevkQMRARRKTAKMLMVVVLVFALCYLPISVLNVlkrvfgMFRQASDREAV 280
Cdd:cd15356 186 VLPLALIAFLNGVTVSHL--------------RIQSLQHSVQVLRAIVIAYVICWLPYHARRL------MFCYVPDDAWT 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
6TO7_B      281 YAAFTFSHW-------LVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15356 246 DSLYNFYHYfymltntLFYVSSAVNPLLYNVVSSSFRKLF 285
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
39-313 1.06e-15

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 75.94  E-value: 1.06e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAIcLPASLLVDITeSWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15181  17 GNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLT-FPFSVVESIA-GWVFGTFLCKLVGAIHKLNFYCSSLLLACISV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLlfKSTARRALGSI----LGIWAVSLAIMVPQAAVMECS-SVLPELAARTRAFSVCDERWADDLAPKIYHs 193
Cdd:cd15181  95 DRYLAIVHAI--HSYRHRRLRSVhltcGSIWLVCFLLSLPNLVFLEVEtSTNANRTSCSFHQYGIHESNWWLTSRFLYH- 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 cffIVTYLAPLGLMAMAYFQIFRKLwgRQIPgttsaevkQMRARRKTAKMLMVVVLVFALCYLP---ISVLNVLKRVFGM 270
Cdd:cd15181 172 ---VVGFFLPLLIMGYCYATIVVTL--CQSS--------RRLQKQKAIRVAILVTLVFCLCWLPyniVIFLDTLDDLKAV 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
6TO7_B      271 FRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15181 239 VKNCKLNDLLDAAITVTESLGFSHCCLNPILYAFIGVKFRNDL 281
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
60-309 1.20e-15

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 75.86  E-value: 1.20e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       60 FLVNLSLADVLATaICLP--ASLLVDiTESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPL--LFKSTAR 135
Cdd:cd15201  38 YLFNLAVADFLLI-ICLPfrTDYYLR-GKHWKFGDIPCRIVLFMLAMNRAGSIFFLTAVAVDRYFRVVHPHhrINSISVR 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      136 RALGSILGIWAVSLAIMV---------PQAAVMECSSvlpelaartraFSVCDERWADDlapkIYHSCFFIVTYLAPLGL 206
Cdd:cd15201 116 KAAIIACGLWLLTIAMTVylltkkhlfPRGNATQCES-----------FNICTGTDSSS----NWHEAMFLLEFFLPLAI 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      207 MAMAYFQIFRKLWGRQIPgttsaevKQMRARRKTaKMLMVVVLVFALCYLP--ISVLNVLKRVFGMFRQASDREAVYAAF 284
Cdd:cd15201 181 ILYCSVRIIWQLRGRQLD-------RHAKIKRAV-QFIMVVAIVFIICFLPsnVTRIAIWILKHTSNEDCQYYRSVDLAF 252
                       250       260
                ....*....|....*....|....*
6TO7_B      285 TFSHWLVYANSAANPIIYNFLSGKF 309
Cdd:cd15201 253 YITISFTYFNSMLDPVVYYFSSPSF 277
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
39-313 1.43e-15

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 76.02  E-value: 1.43e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGH-----ALCKVIPYLQAVSVSVAVLTL 113
Cdd:cd15128  17 GNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIVIDLPINVYKLLAMDWPFGDqpfgqFLCKLVPFIQKASVGITVLNL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      114 SFIALDRWYAICHPLLFKSTA--RRALGSILGIWAVSLAIMVPQAAVMecssVLPELAARTRAFSVCDERwADDLAPKIY 191
Cdd:cd15128  97 CALSVDRYRAVASWSRIQGIGipMWTAVEIVMIWMLSAVLAVPEAIGF----DMVRFNYKGVTLRTCLLR-PETSFMKFY 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      192 HSC----FFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRV 267
Cdd:cd15128 172 IDVkdwwLFGFYFCLPLVCTAIFYTLMTCEMLRKRNGMLRIALNEHLKQRREVAKTVFCLVVIFALCWLPLHLSRILKLT 251
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
6TO7_B      268 fgMFRQASDREAVYAAFT-----FSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15128 252 --VYDQNDPNRCELLSFLlvldyFGINLATLNSCINPIALYFVSRKFKNCF 300
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
39-313 1.46e-15

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 75.75  E-value: 1.46e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTN---YFLVNLSLADVLATAICLPASL--LVDITESWLFGHALCKVIPYLQAVSVSVAVLTL 113
Cdd:cd15130  17 GNSVTLFTLARKKSLQSLQStvrYHLGSLALSDLLILLLAMPVELynFIWVHHPWAFGDAGCRGYYFLRDACTYATALNV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      114 SFIALDRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVMECSSvlpELAARTRAFSVCDERWADDLAPKIY 191
Cdd:cd15130  97 ASLSVERYLAICHPFKAKTlmSRSRTKKFISAIWLASALLAIPMLFTMGLQN---ESDDGTHPGGLVCTPIVDTATLKVV 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      192 HSCFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsaevkqMRARRKTAKMLMVVVLVFALCYLPISVLNVlkrvfgMF 271
Cdd:cd15130 174 IQVNTFMSFLFPMLVTSILNTVIANKL---------------VQALRRGVLVLRAVVIAFVVCWLPYHVRRL------MF 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
6TO7_B      272 RQASDREAVYAAFTFSHW-------LVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15130 233 CYISDEQWTTFLFDFYHYfymltnaLFYVSSAINPILYNLVSANFRQVF 281
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
37-313 1.56e-15

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 75.67  E-value: 1.56e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       37 LVGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHA-----LCKVIPYLQAVSVSVAVL 111
Cdd:cd15975  15 MVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYIVIDIPINVYKLLAQKWPFDDSsfgvfLCKLVPFLQKASVGITVL 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      112 TLSFIALDRWYAIchpllfkSTARRALGS---------ILGIWAVSLAIMVPQAAVMecssVLPELAARTRAFSVCDERW 182
Cdd:cd15975  95 NLCALSVDRYRAV-------ASWSRVQGIgiplitaieIFSIWVLSFILAIPEAIGF----VMVPFEYNGEQYRTCMLNA 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      183 ADDLA---PKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPIS 259
Cdd:cd15975 164 TTKFMnfyVDAKDWWLFGFYFCVPLACTAIFYTLMTCEMLNRRKGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLH 243
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
6TO7_B      260 VLNVLKRVfgMFRQASDREAVYAAFT-----FSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15975 244 LSRILKKT--VYNENDPRRCELLSFLlvmdyISINLATMNSCINPIALYFVSKKFKNCF 300
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
39-313 1.79e-15

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 75.51  E-value: 1.79e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADvLATAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15161  17 GNTLALWLFIHDRKSGTPSNVFLMHLAVAD-LSYVLILPMRLVYHLSGNhWPFGEVPCRLAGFLFYLNMYASLYFLACIS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKSTaRRAL------GSILGIWAVSLAIMVPQAAVMECSSVlpelaartrafSVCDERWADDLAPKIY 191
Cdd:cd15161  96 VDRFLAIVHPVKSMKI-RKPLyahvvcGFLWVIVTVAMAPLLVSPQTVEVNNT-----------TVCLQLYREKASRGAL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      192 HScfFIVTYLAPLGLMAMAYFQIFRKLwgrqipgtTSAEVKQMRARRKTAKMLMVVVLVFALCYLP--ISVLNVLKRVFG 269
Cdd:cd15161 164 VS--LAVAFTIPFVTTVTCYLLIIRSL--------RTGKREEKPLKDKAIKMIILVLTIFLICFVPyhISRYIYILSHNG 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
6TO7_B      270 MFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15161 234 AGASCSSRRGLALANRITSCLTCLNGALDPVMYFFVAEKFRETL 277
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
39-313 2.13e-15

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 75.25  E-value: 2.13e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15306  17 GNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAmWPLPLVLCPIWLFLDVLFSTASIMHLCAIS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKSTARRA--LGSILGIWAVSLAIMVPqaavMECSSVLPELAARTRAFSVCD-ERWADDLapkIYHSc 194
Cdd:cd15306  97 LDRYIAIKKPIQASQYNSRAtaFIKITVVWLISIGIAIP----VPIKGIETDVDNPNNITCVLTkERFGDFI---LFGS- 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 ffIVTYLAPLGLMAMAYFQIFRKLWGRQIPGttsaevkqmraRRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGmfrqA 274
Cdd:cd15306 169 --LAAFFTPLAIMIVTYFLTIHALRKQTITN-----------EQRASKVLGIVFFLFLLMWCPFFITNITSVLCD----S 231
                       250       260       270
                ....*....|....*....|....*....|....*....
6TO7_B      275 SDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15306 232 CNQTTLQMLMEIFVWIGYVSSGVNPLVYTLFNKTFRDAF 270
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
39-264 2.20e-15

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 75.31  E-value: 2.20e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLaTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15079  17 GNGLVIYIFSTTKSLRTPSNMLVVNLAISDFL-MMIKMPIFIYNSFYEGWALGPLGCQIYAFLGSLSGIGSIWTNAAIAY 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPL-LFKSTARRALGSILGIWAVSLAIMVPQAAVMeCSSVLPELAARTRAFsvcdERWADDLAPKIYHSCFFI 197
Cdd:cd15079  96 DRYNVIVKPLnGNPLTRGKALLLILFIWLYALPWALLPLLFG-WGRYVPEGFLTSCSF----DYLTRDWNTRSFVATIFV 170
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
6TO7_B      198 VTYLAPLGLMAMAYFQIFRKLW---------GRQIPGTT---SAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVL 264
Cdd:cd15079 171 FAYVIPLIIIIYCYSFIVKAVFahekalreqAKKMNVVSlrsNADANKQSAEIRIAKVALTNVFLWFIAWTPYAVVALI 249
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
39-309 3.56e-15

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 74.47  E-value: 3.56e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADvLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15121  17 GNLFVVWSVLCRMKKRSVTCILVLNLALAD-AAVLLTAPFFLHFLSGGGWEFGSVVCKLCHYVCGVSMYASIFLITLMSM 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFK--STARRALGSILGIWAVSLAIMVPqaaVMECSSVLPelaaRTRAFSVCDERWADDlAPKIYHSCFF 196
Cdd:cd15121  96 DRCLAVAKPFLSQkmRTKRSVRALLLAIWIVAFLLSLP---MPFYRTVLK----KNINMKLCIPYHPSV-GHEAFQYLFE 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVT-YLAPLGLMAMAYFQIFRKLwgrqipgttsaEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQAS 275
Cdd:cd15121 168 TITgFLLPFTAIVTCYSTIGRRL-----------RSARFRRKRRTNRLVVLIIATFALFWLPYHVVNLIQVAGALQNQAG 236
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      276 DREAVYAAFTFSH---WLVYANSAANPIIYNFLSGKF 309
Cdd:cd15121 237 NASVLKAAKLARPnvtALAFLSSSVNPVLYAFAGGSL 273
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
39-313 4.91e-15

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 74.03  E-value: 4.91e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVW---RNHHMRTVTNYFLVNLSLADVLATaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSF 115
Cdd:cd15154  14 GLLLNAVALWvfvRYLRLHSVVSIYMCNLALSDLLFT-LSLPLRIYYYANHYWPFGNFLCQFSGSIFQMNMYGSCLFLMC 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      116 IALDRWYAICHPLLFKSTARRALGSI--LGIWAVSLAIMVPQAAVMECSSVLpelaARTRAFSVCDERWADDLAPKIYHS 193
Cdd:cd15154  93 INVDRYLAIVHPLRFRHLRRPKVARLlcLAVWALILGGSVPAAIVHSSSDCL----LHGEKVYRCFESFSDNDWKGLLPL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 CFF--IVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSaevkqmraRRKTAKMLMVVVLVFALCYLPisvLNVLKRVFGMF 271
Cdd:cd15154 169 VVLaeILGFLLPLAAVLYCSCRIFVELCRTQEPQQGR--------RRKTVRLLLVNLVIFLICFVP---YNTTLAVYGLL 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
6TO7_B      272 R------QASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15154 238 RanlvedTWNIKDTLRKVLSVTVLLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
45-309 5.48e-15

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 74.07  E-value: 5.48e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       45 LAVWRNHHMRTVTNYFLVNLSLADVlATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAI 124
Cdd:cd15122  25 ILWKMKARGRSVTCILILNLAVADG-AVLLLTPFFITFLTRKTWPFGQAVCKAVYYLCCLSMYASIFIIGLMSLDRCLAV 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      125 CHPLLFKSTARRALGS--ILGIWAVSLAIMVPQAAVMEcssVLPELAARTRafsVCDERWADDlAPKIYHSCF-FIVTYL 201
Cdd:cd15122 104 TRPYLAQSLRKKALVRkiLLAIWLLALLLALPAFVYRH---VWKDEGMNDR---ICEPCHASR-GHAIFHYTFeTLVAFV 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      202 APLGLMAMAYFQIFRKLWGRqipgttsaevkQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFR---QASDRE 278
Cdd:cd15122 177 LPFGVILFSYSVILVRLKGA-----------RFRRRARVEKLIAAIVVAFALLWVPYHVVNLLQVVANLAPgevLEKLGG 245
                       250       260       270
                ....*....|....*....|....*....|.
6TO7_B      279 AVYAAFTFSHWLVYANSAANPIIYNFLSGKF 309
Cdd:cd15122 246 AAKAARAGATALAFFSSSVNPLLYVFAAGDL 276
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-312 1.12e-14

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 73.26  E-value: 1.12e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMR-TVTNYFLVNLSLADvLATAICLPA-SLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 116
Cdd:cd15190  27 GNGLVLWTVFRSKRKRrRSADTFIANLALAD-LTFVVTLPLwAVYTALGYHWPFGSFLCKLSSYLVFVNMYASVFCLTGL 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      117 ALDRWYAICHPLlfKSTARRALGSILgiwaVSLAIMVPQAAVMecssVLPELAARTRAFSVCDERWADDL----APKIYH 192
Cdd:cd15190 106 SFDRYLAIVRSL--ASAKLRSRTSGI----VALGVIWLLAALL----ALPALILRTTSDLEGTNKVICDMdysgVVSNES 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      193 SCFFIVT---------YLAPLGLMAMAYFQIFRKLwGRQIPGTTSAEVKQmraRRKTAKMLMVVVLVFALCYLPISVLNV 263
Cdd:cd15190 176 EWAWIAGlglsstvlgFLLPFLIMLTCYFFIGRTV-ARHFSKLRRKEDKK---KRRLLKIIITLVVTFALCWLPFHLVKT 251
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
6TO7_B      264 LKRVFGMFR---QASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQ 312
Cdd:cd15190 252 LYALMYLGIlpfSCGFDLFLMNAHPYATCLAYVNSCLNPFLYAFFDPRFRQQ 303
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
39-313 1.32e-14

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 72.84  E-value: 1.32e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVcLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15117  17 GNGLV-IWVTGFRMTRTVTTVCFLNLAVADFAFCLFLPFSVVYTALGFHWPFGWFLCKLYSTLVVFNLFASVFLLTLISL 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVP----QAAVMECSSVLPELAARTRAFSVCDERWADDLAPKIYH 192
Cdd:cd15117  96 DRCVSVLWPVWARNhrTPARAALVAVGAWLLALALSGPhlvfRDTRKENGCTHCYLNFDPWNETAEDPVLWLETVVQRLS 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      193 S---CFFIVTYLAPLGLMAMAYFQIFRKLWGRQIpgttsaevkqMRARRKTaKMLMVVVLVFALCYLPISVLNVLK--RV 267
Cdd:cd15117 176 AqviTRFVLGFLVPLVIIGGCYGLIAARLWREGW----------VHSSRPF-RVLTAVVAAFFLCWFPFHLVSLLElvVI 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
6TO7_B      268 FGMFRQASDREAVYAAFTFShwLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15117 245 LNQKEDLNPLLILLLPLSSS--LACVNSCLNPLLYVFVGRDFRERL 288
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
39-315 2.49e-14

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 72.89  E-value: 2.49e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B        39 GNTLVcLAVWRNHHMRTVTNYFLVNLSLADVLATAIcLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:PHA03087  57 GNIIV-IYVLTKTKIKTPMDIYLLNLAVSDLLFVMT-LPFQIYYYILFQWSFGEFACKIVSGLYYIGFYNSMNFITVMSV 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELaartrafsVCDERWADD---LAPKI-YH 192
Cdd:PHA03087 135 DRYIAIVHPVKSNKinTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETL--------ICCMFYNNKtmnWKLFInFE 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       193 SCFFivTYLAPLGLMAMAYFQIFRKLWGRQIPgttsaevkqmRARRKTAKMLMVVVLVFALCYLP--ISVLNVLKRVFGM 270
Cdd:PHA03087 207 INII--GMLIPLTILLYCYSKILITLKGINKS----------KKNKKAIKLVLIIVILFVIFWLPfnVSVFVYSLHILHF 274
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
6TO7_B       271 FRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKA 315
Cdd:PHA03087 275 KSGCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKK 319
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
39-313 3.23e-14

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 71.85  E-value: 3.23e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVclAVWR-NHHMRTVTNYFLV-NLSLADVLaTAICLPASLLVDI---------TESWLFGhALCKVIPYLQAVSVS 107
Cdd:cd15137  17 GNLFV--LIWRlKYKEENKVHSFLIkNLAIADFL-MGVYLLIIASVDLyyrgvyikhDEEWRSS-WLCTFAGFLATLSSE 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      108 VAVLTLSFIALDRWYAICHPLLF-KSTARRALGSILGIWAVSLAImvpqaavmecsSVLPELAART-RAF----SVC--- 178
Cdd:cd15137  93 VSVLILTLITLDRFICIVFPFSGrRLGLRRAIIVLACIWLIGLLL-----------AVLPLLPWDYfGNFygrsGVClpl 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      179 ---DERwaddLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSaevkQMRARRKTAKMLMVVVLVFALCY 255
Cdd:cd15137 162 hitDER----PAGWEYSVFVFLGLNFLAFVFILLSYIAMFISIRRTRKAAASR----KSKRDMAVAKRFFLIVLTDFLCW 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
6TO7_B      256 LPISVLNVLkrvfGMFRQASDREaVYAaftfshWLVY----ANSAANPIIYNFLSGKFREQF 313
Cdd:cd15137 234 IPIIVIGIL----ALSGVPIPGE-VYA------WVAVfvlpINSALNPILYTLSTPKFRKKL 284
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
39-313 3.24e-14

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 71.69  E-value: 3.24e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADvLATAICLPASLLVDITE-SWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15192  17 GNSLVVIVIYCYMKLKTVANIFLLNLALAD-LCFLITLPLWAAYTAMEyHWPFGNFLCKIASALVSFNLYASVFLLTCLS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLlfKSTARRALgsilgIWAVSLAIMVPQAAVMecsSVLPELAARTRAF------SVCDERWADDLAPKIY 191
Cdd:cd15192  96 IDRYLAIVHPM--KSRLRRTL-----VVARVTCIVIWLLAGV---ASLPAIIHRDVFFientniTVCAFHYPSQNSTLLV 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      192 HSCFF--IVTYLAPLGLMAMAYFQIFRKLwgrqipgTTSAEVKQMRARRKTA-KMLMVVVLVFALCYLPISVLNVLKRVF 268
Cdd:cd15192 166 GLGLMknLLGFLIPFLIILTCYTLIGKAL-------KKAYEIQRNKPRNDEIfKMIMAVVLFFFFCWIPHQIFTFLDVLI 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
6TO7_B      269 GM--FRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15192 239 QLkvIQDCHIADIVDTAMPFTICIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
45-313 3.40e-14

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 71.87  E-value: 3.40e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       45 LAVWR-NHHMR--TVTNYFLVNLSLADVLaTAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIALDR 120
Cdd:cd15377  20 VAIWMfVFHMKpwSGISVYMFNLALADFL-YVLTLPALIFYYFNKTdWIFGDAMCKLQRFIFHVNLYGSILFLTCISVHR 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      121 WYAICHPLlfkstarRALGSILGIWAVSLAIMVPQAAVMECSSVL--PELAARTRAFSVCDERWADDLAPK--IYHSCFF 196
Cdd:cd15377  99 YTGVVHPL-------KSLGRLKKKNAICISVLVWLIVVVAISPILfySGTGVRKNKTITCYDTTSDEYLRSyfIYSMCTT 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKLWGRQIPGTtsaEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASD 276
Cdd:cd15377 172 VAMFCVPFILILGCYGLIVRALIYKDMKYT---EENNAPLRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRARLDFQTPA 248
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
6TO7_B      277 ----REAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15377 249 mcafNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRL 289
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
39-310 8.53e-14

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 70.54  E-value: 8.53e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15073  17 SNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLLTVVAV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF-KSTARRALGSILGIW--AVSLAIMvpqaAVMECSSVLPELAARTrafsvCDERWA-DDLAPKIYHSC 194
Cdd:cd15073  97 DRYLTICRPDLGrKMTTNTYTVMILLAWtnAFFWAAM----PLVGWASYALDPTGAT-----CTINWRkNDSSFVSYTMS 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNvlkrVFGMFRQA 274
Cdd:cd15073 168 VIVVNFIVPLAVMFYCYYNVSRFVKKVLASDCLESVNIDWTDQNDVTKMSVIMIVMFLVAWSPYSIVC----LWASFGEP 243
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      275 SDreaVYAAFTFSHWLVYANSAA-NPIIYNFLSGKFR 310
Cdd:cd15073 244 KK---IPPWMAIIPPLFAKSSTFyNPCIYVIANKKFR 277
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
39-313 9.91e-14

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 70.20  E-value: 9.91e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15296  17 GNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVDYLLCTASVFNIVLISY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF---KSTARRALGSILGIWAVSLAIMVPQAAVMEC---SSVLPElaartrafsvcDERWADdlapkIYH 192
Cdd:cd15296  97 DRFLSVTRAVSYraqKGMTRQAVLKMVLVWVLAFLLYGPAIISWEYiagGSIIPE-----------GECYAE-----FFY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      193 SCFFIVT-----YLAPLGLMAMAYFQIFRKLWGRQIpgttsaevkQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRV 267
Cdd:cd15296 161 NWYFLMTastleFFTPFISVTYFNLSIYLNIQKRRF---------RLSRDKKVAKSLAIIVCVFGLCWAPYTLLMIIRAA 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
6TO7_B      268 fgmfrqASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15296 232 ------CHGHCVPDYWYETSFWLLWVNSAINPVLYPLCHMSFRRAF 271
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
39-310 1.02e-13

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 70.19  E-value: 1.02e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLaTAICLPAsLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15177  17 GNGLVLATHTRYRRLRSMTDVYLLNLALADLL-LLLTLPF-AAAETLQGWIFGNAMCKLIQGLYAINFYSGFLFLTCISV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPL----LFKSTARRALGSILGIWAVSLAIMVPQaavmecssVLPELAARTRAFSVCDERWADDL---APKIY 191
Cdd:cd15177  95 DRYVVIVRATsahrLRPKTLFYSVLTSLIVWLLSILFALPQ--------LIYSRVENRSELSSCRMIFPEVVsrtVKGAT 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      192 HSCFFIVTYLAPLGLMAMAYFQIfrklwGRQIPGTTSAEvkqmraRRKTAKMLMVVVLVFALCYLPISVLNVLKR---VF 268
Cdd:cd15177 167 ALTQVVLGFAIPLIVMAVCYAAI-----GRTLLAARGWE------RHRALRVIAALVVAFVLFQLPYSVVLLLDTadlLA 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
6TO7_B      269 GMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15177 236 TLELSCSQSKRKDIALLVTSGLAYVRCCLNPLLYAFVGVRFR 277
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
39-313 1.06e-13

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 70.23  E-value: 1.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMR---TVTNYFLVNLSLADVLataICLPASLLVDI---TESWLFGHALCKVIPYLQAVSVSVAVLT 112
Cdd:cd15338  17 GNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDLL---FLLGMPFLIHQllgNGVWHFGETMCTLITALDTNSQITSTYI 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      113 LSFIALDRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVP----------QAAVMECSSVLPELAARTRAFSVCDe 180
Cdd:cd15338  94 LTVMTLDRYLATVHPIRSTKirTPRVAVAVICLVWILSLLSITPvwmyaglmplPDGSVGCALLLPNPETDTYWFTLYQ- 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      181 rwaddlapkiyhscfFIVTYLAPLGLMAMAYFQIFRKLWGRQIPgtTSAEVKQMRARRKTaKMLMVVVLVFALCYLPISV 260
Cdd:cd15338 173 ---------------FFLAFALPLVVICVVYFKILQNMASTVAP--LPQRSLRVRTKKVT-RMAVAICLAFFICWAPFYI 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
6TO7_B      261 LNVLKrvFGMFRQASdreAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15338 235 LQLAH--LSIDRPSL---AFLYAYNVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
39-313 1.09e-13

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 70.17  E-value: 1.09e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAiCLPAsLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15172  17 GNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVL-TLPF-WAVYEAHQWIFGNFSCKLLRGIYAINFYSGMLLLACISV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLL-FKSTARRALGS---ILGIWAVSLAIMVPQAAVMECSSVlpelaaRTRAFSVCDERWADDLAPKIYHSC 194
Cdd:cd15172  95 DRYIAIVQATKsFRLRSRTLAYSkliCAAVWLLAILISLPTFIFSEVYDF------GLEEQYVCEPKYPKNSTAIMWKLL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVT----YLAPLGLMAMAYFQIFRKLwgrqipgttsaEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKR-VFG 269
Cdd:cd15172 169 VLSLQvslgFFIPLLVMIFCYSFIIKTL-----------LQAQNSQRHKAVRVVVAVVLVFLVCQVPYNIVLLIEAiNLG 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
6TO7_B      270 MFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15172 238 EQQSCSSEKAVAYAKTITECLAFFHCCLNPVLYAFIGVKFRNYF 281
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
45-302 1.47e-13

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 69.72  E-value: 1.47e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       45 LAVW-------RNHHMRTVtnyFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15376  20 LALWlfvtrerRPWHTGVV---FSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFLFTCNLYGSIFFITCIS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKSTAR--RALGSILGIWAVSLAIMVPqaaVMECSSVLPELAARTRAFSVCDerwaDDLAPKIYHSCF 195
Cdd:cd15376  97 LNRYLGIVHPFFTRSHVRpkHAKLVSLAVWLLVAALSAP---VLSFSHLEVERHNKTECLGTAV----DSRLPTYLPYSL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTY--LAPLGLMAMAYFQIFRKLWgrQIPGTTSAEvkqmraRRKTAKMLMVVVLVFALCYLPISVL---NVLKRVFGM 270
Cdd:cd15376 170 FLAVVgcGLPFLLTLASYLAIVWAVL--RSPGITTLE------KRKVAALVAVVVALYAVSFVPYHILrnlNLYRRLQWL 241
                       250       260       270
                ....*....|....*....|....*....|..
6TO7_B      271 FRQASDReaVYAAFTFSHWLVYANSAANPIIY 302
Cdd:cd15376 242 KAAASLR--IYFAYQVTKGLVTLNMCIHPLLY 271
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
39-310 1.74e-13

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 69.48  E-value: 1.74e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAiCLPASLLVDITEsWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15186  17 GNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVA-TLPFWTHYLINE-WGLHNAMCKLTTAFFFIGFFGGIFFITVISI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPL--LFKSTARRALGSILGIWAVSLAIMVPQAAVM-----ECSSVLPElaartrafsVCDERWaddlaPKIY 191
Cdd:cd15186  95 DRYLAIVLAAnsMNNRTVQHGVTISLGVWAAAILVAVPQFMFTkmkenECLGDYPE---------VLQEIW-----PVLR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      192 HSCFFIVTYLAPLGLMAMAYFQIFRKLWGrqipgttsaevKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLK--RVFG 269
Cdd:cd15186 161 NVELNFLGFLLPLLIMSYCYFRIIQTLFS-----------CKNHKKARAIKLILLVVIVFFLFWTPYNVMIFLEtlKLYD 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
6TO7_B      270 MFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15186 230 FFPSCDMKKDLRLALSVTETIAFSHCCLNPLIYAFAGEKFR 270
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
39-312 2.70e-13

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 69.02  E-value: 2.70e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTnyFLVNLSLADVLATAICLPASLLVD--ITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 116
Cdd:cd15220  16 GNTAVMVVIAKTPHLRKFA--FVCHLCVVDLLAALLLMPLGILSSspFFLGVVFGEAECRVYIFLSVCLVSASILTISAI 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      117 ALDRWYAICHPLLF--KSTARRALGSILGIWAVSLAImvpqAAVMECSSVLPELAArTRAFSVCDERWADDLAPKIYHSC 194
Cdd:cd15220  94 SVERYYYIVHPMRYevKMTIGLVAAVLVGVWVKALLL----GLLPVLGWPSYGGPA-PIAARHCSLHWSHSGHRGVFVVL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVTYLAPLGLMAMAYFQIFRKLWGrqipgttsaevkqmrarRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQA 274
Cdd:cd15220 169 FALVCFLLPLLLILVVYCGVFKVFGG-----------------GKAALTLAAIVGQFLCCWLPYFAFHLYSALAASPVSG 231
                       250       260       270
                ....*....|....*....|....*....|....*...
6TO7_B      275 SDREAVYAaftfshWLVYANSAANPIIYNFLSGKFREQ 312
Cdd:cd15220 232 GEAEEVVT------WLAYSCFAVNPFFYGLLNRQIREE 263
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
40-310 2.76e-13

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 69.08  E-value: 2.76e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 119
Cdd:cd15076  18 NAIVLFVTIKYKKLRQPLNYILVNISLAGFIFCIFSVFPVFVASAQGYFFFGRTVCALEAFVGSLAGLVTGWSLAFLAFE 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      120 RWYAICHPL-LFKSTARRALGSILGIWAVSLAIMVPqaAVMECSSVLPELAArtrafSVCDERW---ADDLAPKIYHSCF 195
Cdd:cd15076  98 RYIVICKPFgNFRFGSKHALGAVVATWIIGIGVSLP--PFFGWSRYIPEGLQ-----CSCGPDWytvGTKYRSEYYTWFL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKLwgRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVlkrvfgMFRQAS 275
Cdd:cd15076 171 FIFCFIVPLSIIIFSYSQLLGAL--RAVAAQQQESASTQKAEREVSRMVVVMVGSFCLCYVPYAALAM------YMVNNR 242
                       250       260       270
                ....*....|....*....|....*....|....*
6TO7_B      276 DREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15076 243 DHGLDLRLVTIPAFFSKSSCVYNPIIYCFMNKQFR 277
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
55-310 2.85e-13

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 69.03  E-value: 2.85e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       55 TVTNYFLVNLSLADVLaTAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPL--LFK 131
Cdd:cd15968  33 TRTAIYMVNLALADLL-YALSLPLLIYNYAMRDrWLFGDFMCRLVRFLFYFNLYGSILFLTCISVHRYLGICHPMrpWHK 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      132 STARRALGSILGIWAVSLAIMVPQAavmecssvlpeLAART---RAFSVCDERWADDLAPK--IYHSCFFIVTYLAPLGL 206
Cdd:cd15968 112 ETRRAAWLTCVLVWILVFAQTLPIL-----------IFARTgiiRNRTVCYDLAPPALFPHyvPYGMALTVSGFLLPFSI 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      207 MAMAYFQIFRKLwgrqIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASDR--EAVYAAF 284
Cdd:cd15968 181 ILWCYCLVVRTL----CRTLGPAEPPAQARRRKSIRTIVTVTLLFALCFLPFHITRTIYLAVRVTPGVPCHvlEAVAACY 256
                       250       260
                ....*....|....*....|....*.
6TO7_B      285 TFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15968 257 KITRPLASANSVLNPLLYFLTKKKFG 282
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
39-310 3.30e-13

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 70.04  E-value: 3.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B        39 GNTLVCLAVWrNHHMRTVTNYFLVNLSLADVLATaICLPAsLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:PHA02638 115 GNAAIIMILF-CKKIKTITDIYIFNLAISDLIFV-IDFPF-IIYNEFDQWIFGDFMCKVISASYYIGFFSNMFLITLMSI 191
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       119 DRWYAICHPLLFKSTARRALGSILGI--WAVSLAIMVPQAAVMECSSVLPELAARTRAFS-----VCDERWADDLA--PK 189
Cdd:PHA02638 192 DRYFAILYPISFQKYRTFNIGIILCIisWILSLIITSPAYFIFEASNIIFSAQDSNETISnyqctLIEDNEKNNISflGR 271
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       190 IYHSCFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsaevKQMRARRKTAKMLMVVVLVFA--LCYLPISVLNVLKRV 267
Cdd:PHA02638 272 ILQFEINILGMFIPIIIFAFCYIKIILKL-------------KQLKKSKKTKSIIIVSIIIICslICWIPLNIVILFATM 338
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
6TO7_B       268 FGM--FRQ-ASDREAVYAAFTFSHWLVYANSAA----NPIIYNFLSGKFR 310
Cdd:PHA02638 339 YSFkgFNSiISEHICGFIKLGYAMMLAEAISLThcciNPLIYTLIGENFR 388
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
60-312 3.35e-13

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 68.62  E-value: 3.35e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       60 FLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS--TARRA 137
Cdd:cd15372  37 FLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAFFYGNMYCSVLLLMCISLDRYLAVVHPFFARTlrSRRFA 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      138 LGSILGIWAVSLAIMVPQAAVME-----------CSSVLPELAARTRAFSvcderwaddlapkiYHSCFFIVTYLAPLGL 206
Cdd:cd15372 117 LCMCTAIWLIAAALTLPLTLQRQsyplerlnitlCHDVLPLDEQDTYLFY--------------YFACLAVLGFLLPLVV 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      207 MAMAYFQIFRKLwgrqipgttsaevkqMRARRKTAKMLMVVVLV---FALCYLPIsvlNVLKRVFGMFRQASDREAVYAA 283
Cdd:cd15372 183 ILFCYGSVLHTL---------------LRSGQRYGHAMKLTVLVlvsFVLCFTPS---NLLLLLHYSDPTLDDGGNLYIV 244
                       250       260
                ....*....|....*....|....*....
6TO7_B      284 FTFSHWLVYANSAANPIIYNFLSGKFREQ 312
Cdd:cd15372 245 YMVSLAISTLNSCVDPFIYYYVSEEFRDK 273
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
39-313 4.10e-13

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 68.61  E-value: 4.10e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAIcLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15087  17 GNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLV-LPINIAEHLLQQWPFGELLCKLILSIDHYNIFSSIYFLTVMSV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARR----ALGSILGIWAVSLAIMVPQAAVMECSSvlPELAARTRAFSVCDERWADDLAPKIYHsc 194
Cdd:cd15087  96 DRYLVVLATVRSRRMPYRtyraAKIVSLCVWLLVTIIVLPFTVFAGVYS--NELGRKSCVLSFPSPESLWFKASRIYT-- 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 fFIVTYLAPLGLMAMAYFQIFRKLwgRQIPGTTSAEVKQmRARRKTAKMLMVVVLVFALCYLPISvlnvLKRVFGMFRQA 274
Cdd:cd15087 172 -LVLGFAIPVSTICILYTMMLYKL--RNMRLNSNAKALD-KAKKKVTLMVLVVLAVCLFCWTPFH----LSTVVALTTDL 243
                       250       260       270
                ....*....|....*....|....*....|....*....
6TO7_B      275 SDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15087 244 PQTPLVIGISYFITSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
39-312 4.20e-13

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 68.69  E-value: 4.20e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHmRTVTNYFLVNLSLADVLATaICLPASL--LVDITEsWLFGHALCKVIPYLQAVSVSVAVLTLSFI 116
Cdd:cd15339  17 GNILVLFTIIRSRK-KTVPDIYVCNLAVADLVHI-IVMPFLIhqWARGGE-WVFGSPLCTIITSLDTCNQFACSAIMTAM 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      117 ALDRWYAICHPllFKSTARRALGSI----LGIWAVSLAIMVPqaaVMecssvlpeLAARTRAFSVCDERWADDL-APK-- 189
Cdd:cd15339  94 SLDRYIALVHP--FRLTSLRTRSKTirinLLVWAASFILVLP---VW--------VYAKVIKFRDGLESCAFNLtSPDdv 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      190 -IYHSCFFIVTYLAPLGLMAMAYFQIFRKLWG----RQIPGTTSAEVKQMRARRKTaKMLMVVVLVFALCYLPISVLNVL 264
Cdd:cd15339 161 lWYTLYQTITTFFFPLPLILICYILILCYTWEmyrkNKKAGRYNTSIPRQRVMRLT-KMVLVLVGVFLVSAAPYHVIQLV 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
6TO7_B      265 KrvfgmFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQ 312
Cdd:cd15339 240 N-----LSVSQPTLAFYVSYYLSICLSYASSSINPFLYILLSGNFRKR 282
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
39-313 5.65e-13

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 68.07  E-value: 5.65e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15297  17 GNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISF 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPQAAVMEC---SSVLPELAARTRAFSVCDERWADDLApkiyhs 193
Cdd:cd15297  97 DRYFCVTKPLTYpvKRTTKMAGMMIAAAWVLSFILWAPAILFWQFivgGRTVPEGECYIQFFSNAAVTFGTAIA------ 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 cffivTYLAPLGLMAMAYFQIFRklwgrqipgTTSAEvkqmrarRKTAKMLMVVVLVFALCYLPISVLNVLKrvfgMFRQ 273
Cdd:cd15297 171 -----AFYLPVIIMTVLYWQISR---------ASSRE-------KKVTRTILAILLAFIITWTPYNVMVLIN----TFCA 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
6TO7_B      274 ASDREAVYaafTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15297 226 SCIPNTVW---TIGYWLCYINSTINPACYALCNATFKKTF 262
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
40-310 6.64e-13

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 67.97  E-value: 6.64e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 119
Cdd:cd15084  28 NGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFEGFMVSLTGIVGLWSLAILAFE 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      120 RWYAICHPL-LFKSTARRALGSILGIWAVSLAIMVPqaAVMECSSVLPElAARTRafsvCDERW-ADDLAPKIYHSCFFI 197
Cdd:cd15084 108 RYLVICKPMgDFRFQQRHAVSGCAFTWGWSLLWTSP--PLFGWSSYVPE-GLRTS----CGPNWyTGGTNNNSYILALFV 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      198 VTYLAPLGLMAMAYFQIFRKLwgRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLkrvfgmfrQASDR 277
Cdd:cd15084 181 TCFALPLSTIIFSYSNLLLTL--RAVAAQQKESETTQRAEKEVTRMVIAMVMAFLICWLPYATFAMV--------VATNK 250
                       250       260       270
                ....*....|....*....|....*....|....*
6TO7_B      278 EAVYAAFTFSHWLVYANSAA--NPIIYNFLSGKFR 310
Cdd:cd15084 251 DVVIQPTLASLPSYFSKTATvyNPIIYVFMNKQFR 285
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
40-310 9.31e-13

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 67.62  E-value: 9.31e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 119
Cdd:cd15081  30 NGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVLEGFTVSVCGITGLWSLTIISWE 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      120 RWYAICHPL-LFKSTARRALGSILGIWAVSLAIMVPqaAVMECSSVLP---ELAARTRAFSvcderWADDLAPKIYHSCF 195
Cdd:cd15081 110 RWVVVCKPFgNIKFDGKLAIVGIIFSWVWSAVWCAP--PIFGWSRYWPhglKTSCGPDVFS-----GSSDPGVQSYMIVL 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKLwgRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISvlnvlkrVFGMFRQAS 275
Cdd:cd15081 183 MITCCIIPLAIIILCYLQVWLAI--RAVAQQQKESESTQKAEKEVSRMVVVMIFAYCFCWGPYT-------FFACFAAAN 253
                       250       260       270
                ....*....|....*....|....*....|....*.
6TO7_B      276 DREAVYA-AFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15081 254 PGYAFHPlAAALPAYFAKSATIYNPIIYVFMNRQFR 289
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
39-313 1.09e-12

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 67.49  E-value: 1.09e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADvLATAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15368  17 GNLFSLWLLCFHTKPKTPSIIFMINLSLTD-LMLACFLPFQIVYHIQRNhWIFGKPLCNVVTVLFYANMYSSILTMTCIS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKSTARR--ALGSILGIWAVSLAIMVPqAAVMECSSVLPELAARTrafsvCDERWADDLAPKIYHSCF 195
Cdd:cd15368  96 IERYLGVVYPMRSMRWRKKryAVAACIGMWLLVLTALSP-LERTDLTYYVKELNITT-----CFDVLKWTMLPNIAAWAA 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVT-----YLAPLGLMAMAYFQIFRKLwgrqipgTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGM 270
Cdd:cd15368 170 FLFTlfillFLIPFIITVYCYVLIILKL-------VQTSERYGREQKRRAIYLALIVLLVFITCFAPNNFILLAHMVSRL 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
6TO7_B      271 FRQASdreaVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15368 243 FYGKS----LYHAYKLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
60-311 1.27e-12

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 67.13  E-value: 1.27e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       60 FLVNLSLADVLaTAICLPASLLVDIT-ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLF-KSTARRA 137
Cdd:cd15370  38 YMANLALADLL-FVIWFPLKIAYHINgNNWIYGEALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMSHsRKKANIA 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      138 LGSILGIWAVSLAIMVPQAAVMEcSSVLPELAARTrafsvCDERWADDLA---PKIYHSCFFIVTYLAPLGLMAMAYFQI 214
Cdd:cd15370 117 IGISLAIWLLILLVTIPLYLVKQ-TVFIPALDITT-----CHDVLPEQLLvgdMFNYFLSLAIGVFLFPAFLTAVAYVLM 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      215 FRKLwgrqipgTTSAEVKQMRARRKTAKMLMVVVLV-FALCYLPISVLNVLKRVFgmfRQASDREAVYAAFTFSHWLVYA 293
Cdd:cd15370 191 IRAL-------KSSINDESIEKKRKRAIKLIVTVLVmYLICFTPSNLLLVVHYFL---LKNQGQSSVYAFYITALCLSTL 260
                       250
                ....*....|....*...
6TO7_B      294 NSAANPIIYNFLSGKFRE 311
Cdd:cd15370 261 NSCIDPFVYYFVSHDFRD 278
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
58-311 1.32e-12

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 67.23  E-value: 1.32e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       58 NYFLVNLSLADvLATAICLPASLLVDITE-SWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLlfKSTARR 136
Cdd:cd15926  37 NLFVTSLAVTD-FQFVLTLPFWAVENALDfTWLFGKAMCKIVSYVTAMNMYASVFFLTAMSVARYHSVASAL--KSKRRR 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      137 ALGSI----LGIWAVSLAIMVPQAAVMECSSVLPELAARTRafsVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMAYF 212
Cdd:cd15926 114 GCCSAkwlcVLIWVLAILASLPNAIFSTTATVSNEELCLVK---FPDNRGNAQFWLGLYHAQKVLLGFLIPLGIISLCYL 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      213 QIFRKLWGRQIPGTTSaevkqmRARRKTAKMLMVVVLVFALCYLPISVLN----VLKRVFGMFRQASDREAVYaAFTFSH 288
Cdd:cd15926 191 LLVRFITDKNITGSST------KRRSKVTKSVTIVVLSFFLCWLPNQALTtwgiLIKLNVVHFSYEYFTTQVY-IFPITV 263
                       250       260
                ....*....|....*....|...
6TO7_B      289 WLVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15926 264 CLAHSNSCLNPILYCLMRREFRK 286
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
39-154 1.43e-12

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 67.48  E-value: 1.43e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLL-VDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15005  17 GNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMAsVRHGSGWIYGALSCKVIAFLAVLFCFHSAFTLFCIA 96
                        90       100       110
                ....*....|....*....|....*....|....*....
6TO7_B      118 LDRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVP 154
Cdd:cd15005  97 VTRYMAIAHHRFYAKrmTFWTCLAVICMAWTLSVAMAFP 135
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
39-313 1.46e-12

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 66.72  E-value: 1.46e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADvLATAICLPASLL-VDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd14988  17 ENVLVIWVNWHRWGSKNLVNLYILNMAIAD-LGVVLTLPVWMLeVMLDYTWLWGSFLCKFTHYFYFANMYSSIFFLTCLS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLF----KSTARRALgsILGIWAVSLAIMVPQAAVMECSSVLPELAARTRAFSVCDErWAddLAPKIYHS 193
Cdd:cd14988  96 VDRYLTLTSSSPFwqqhQHRIRRAL--CAGIWVLSAIIPLPEVVHMQLLDGVEPMCLFLAPFETYDE-WA--LAVSLLTL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 cffIVTYLAPLGLMAMAYFQIFRKLwgRQIPGTTSaevkqmrarRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGM--F 271
Cdd:cd14988 171 ---IIGFLIPFSIIAVFNVLTARYI--RTAGRPES---------RRHCLLIYAYILVFVVCWLPYHVTLLLLTLHGShiS 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
6TO7_B      272 RQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd14988 237 LHCNLVHFLYFFYDVIDCFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
39-317 1.76e-12

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 66.37  E-value: 1.76e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15054  17 GNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCSASILNLCVISL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVS-LAIMVP---QAAVMECSSVLPELAARTRAFSVcdeRWADDLAPKIYH 192
Cdd:cd15054  97 DRYLLIISPLRYKLrmTPPRALALILAAWTLAaLASFLPielGWHELGHERTLPNLTSGTVEGQC---RLLVSLPYALVA 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      193 SCffiVTYLAPLGLMAMAYFQIFRklwgrqipgttsAEVKQMRARRktakMLMVVVLVFALCYLPISVLNVLKRVFgmfr 272
Cdd:cd15054 174 SC---LTFFLPSGAICFTYCRILL------------AARKALKASL----TLGILLGMFFVTWLPFFVANVVQAVC---- 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
6TO7_B      273 qasdrEAVYAA-FTFSHWLVYANSAANPIIYNFlsgkFREQFKAAF 317
Cdd:cd15054 231 -----DCVSPGlFDVLTWLGYCNSTMNPIIYPL----FMRDFKRAL 267
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
39-313 1.94e-12

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 66.20  E-value: 1.94e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15300  17 GNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYVASNASVMNLLVISF 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRAlGSILGI-WAVSLAIMVPqaaVMECSSVLpeLAARTRAFSVCDERWADDlaPKIYHSCf 195
Cdd:cd15300  97 DRYFSITRPLTYraKRTPKRA-GIMIGLaWLISFILWAP---PILCWQYF--VGKRTVPERECQIQFLSE--PTITFGT- 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKlwgrqipgttsaEVKQmrarRKTAKMLMVVVLVFALCYLPISVLnVLKRVFgmfrqaS 275
Cdd:cd15300 168 AIAAFYIPVSVMTILYCRIYKE------------TIKE----RKAAQTLSAILLAFIITWTPYNIM-VLVSTF------C 224
                       250       260       270
                ....*....|....*....|....*....|....*...
6TO7_B      276 DREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15300 225 SDCIPLTLWHLGYWLCYVNSTVNPMCYALCNKTFRKTF 262
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
39-310 2.15e-12

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 66.34  E-value: 2.15e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15189  17 GNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSGLPFWAMNILNQFNWPFGELLCRVVNGVIKVNLYTSIYLLVMISQ 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSI--LGIWAVSLAIMVPqAAVMECSSVLPELAARTRAFSVCDERWaddlapKIYHSCFF 196
Cdd:cd15189  97 DRYLALVKTMAARRLRRRRYAKLicVLIWVVGLLLSIP-TFLLRKIKAIPDLNITACVLLYPHEAW------HFAHIVLL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 -IVTYLAPLGLMAMAYFQIFRKLWGRQIPGTtsaevKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVF--GMFRQ 273
Cdd:cd15189 170 nIVGFLLPLLVITFCNYNILQALRTREESTR-----CEDRNDSKATALVLAVTLLFLVCWGPYHFFTFLDFLFdvGVLDE 244
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      274 ASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15189 245 CFWEHFIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFR 281
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
39-311 2.51e-12

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 66.33  E-value: 2.51e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATaICLPAsLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15179  17 GNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFV-LTLPF-WAVDAAANWYFGNFLCKAVHVIYTVNLYSSVLILAFISL 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLlfKSTARRALGS----ILGIWAVSLAIMVPQAAVMECSsvlpELAARTrafsVCDERWADDlAPKIYHSC 194
Cdd:cd15179  95 DRYLAIVHAT--NSQRPRKLLAekvvYVGVWLPALLLTVPDLVFAKVS----ELDDRY----ICDRIYPED-TFELWVVA 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 F----FIVTYLAPLGLMAMAYFQIFRKLwgRQIPGTTsaevkqmraRRKTAKMLMVVVLVFALCYLPISV---LNVLKRV 267
Cdd:cd15179 164 FrfqhILVGLVLPGLVILTCYCIIISKL--SHSKGHQ---------KRKALKTTVILILAFFACWLPYYIgisIDTFMLL 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
6TO7_B      268 FGMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15179 233 EIIKQSCEMEQTVHKWISITEALAFFHCCLNPILYAFLGAKFKT 276
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
39-310 2.65e-12

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 66.14  E-value: 2.65e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15074  17 GNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCSINTLTAISI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHP-LLFKSTARRALGSILGIWAVSLAIMVPqaAVMECSSVLPELAARTrafsvCDERWA---DDLAPKIYHSC 194
Cdd:cd15074  97 YRYLKICHPpYGPKLSRRHVCIVIVAIWLYALFWAVA--PLVGWGSYGPEPFGTS-----CSIDWTgasASVGGMSYIIS 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVTYLAPLGLMAMAYFQIFRKLWG--RQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKrVFGMFR 272
Cdd:cd15074 170 IFIFCYLLPVLIIVFSYVKIIRKVKSsrKRVAGFDSRSKRQHKIERKVTKVAVLICAGFLIAWTPYAVVSMWS-AFGSPD 248
                       250       260       270
                ....*....|....*....|....*....|....*...
6TO7_B      273 QASDREAVYAAFtfshwLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15074 249 SVPILASILPAL-----FAKSSCMYNPIIYLLFSSKFR 281
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
39-313 2.99e-12

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 66.36  E-value: 2.99e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVW----RNHHMRTVTNYfLVNLSLADVLATAICLPASLLVDITE--SWLFGHALCKVIPYLQAVSVSVAVLT 112
Cdd:cd15135  17 GNSATIKVTQvlqkKGYLQKSVTDH-MVSLACSDLLVLLLGMPVELYSAIWDpfATPSGNIACKIYNFLFEACSYATILN 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      113 LSFIALDRWYAICHPLLFKS-TARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTRAFSVCDERWAD-----DL 186
Cdd:cd15135  96 VATLSFERYIAICHPFKYKAlSGSRVRLLICFVWLTSALVALPLLFAMGTEDPLEAFPSYRGTRHHCQDQKSNltictSL 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      187 APK--IYHSCFF--IVTYLAPLG------------LMAMAYFQIFRKLWGRQIPGTTSAEVKQMR-ARRKTAKMLMVVVL 249
Cdd:cd15135 176 SSKwtVFQASIFsaFVLYLLVLAsvafmcrrmmraLMGSKKGAVAVKGPGGSVQLLRKHESAEGKtARKQTILFLGLIVG 255
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
6TO7_B      250 VFALCYLPisvlNVLKRVFGMFRQASD-REAVYAAFT----FSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15135 256 TLAVCWMP----NQIRRIMAAAKPKDDwTRSYFRAYIillpIADTFFYLSSVLNPLLYNLSSQQFRSVF 320
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
39-162 5.61e-12

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 65.26  E-value: 5.61e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15127  17 GNVAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLGDFSCKIVPYIEVASLGVTTFTLCALCI 96
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
6TO7_B      119 DRWYAICHPLLF--------KSTARRALgsilgIWAVSLAIMVPQAAVMECS 162
Cdd:cd15127  97 DRFRAATNVQMYyemienctSTTAKLAV-----IWVGALLLALPEVVLRQLS 143
7tmA_ETBR-LP2 cd15126
endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G ...
39-264 6.06e-12

endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelin B receptor-like protein 2, also called GPR37L1, is almost exclusively expressed in the nervous system. It has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37L1 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320254  Cd Length: 298  Bit Score: 65.27  E-value: 6.06e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15126  17 GNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPVVVFNEITKKRLLGDVSCRVVPYMEVTSLGVTTFSLCALGI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRA---LGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTraFSVCDERWADDLAPKIYH--- 192
Cdd:cd15126  97 DRFHAATSPQPKARPVERCqsiLAKLAVIWVGSMTLAVPELLLWQLAQETSPGSGMV--IDTCIMKPSPNLPESLYSlvl 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      193 -----------SCFFIVTYLaplglmamayFQIFRKLWGRQIPGTTSAEVKQM-----RARRKTAKMLMVVVLVFALCYL 256
Cdd:cd15126 175 tyqnarmwwyfGCYFCLPIL----------FTVTCQLVTLRVSGTSGSSKECKdikhgQCERQLNCTVAGLAVVYGVCTL 244

                ....*...
6TO7_B      257 PISVLNVL 264
Cdd:cd15126 245 PENVCNIV 252
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
39-311 6.72e-12

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 64.86  E-value: 6.72e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15404  17 GNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRVSAMFFWLFVMEGVAILLIISI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPlLFKSTARRALGSILGIWAVSLAIMVPQAAVMecssvlPELAARTRAfSVCDERWADDLAPKIYHSCFFIV 198
Cdd:cd15404  97 DRFLIIVQK-QDKLNPYRAKVLIAVSWAVSFCVAFPLAVGS------PDLQIPSRA-PQCVFGYTTNPGYQAYVILIMLI 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      199 TYLAPLGLMAMAYFQIFRKlwgrqipgttsaeVKQMRARRKTAkmLMVVVLVFALCYLPISVLNVLKRVFGMFRQasdRE 278
Cdd:cd15404 169 FFFIPFMVMLYSFMGILNT-------------VRSFKTRAFTT--ILILFIVFTVCWAPFTTYSLVATFNSHFYH---KH 230
                       250       260       270
                ....*....|....*....|....*....|...
6TO7_B      279 AVYAAFTFSHWLVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15404 231 NFFEISTWLLWLCYLKSALNPLIYYWRIKKFRD 263
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
39-313 7.13e-12

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 64.58  E-value: 7.13e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15214  16 GNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGAIAI 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPqaavmecssvlPELAARTRAFS----VCDERWADDLApkiYH 192
Cdd:cd15214  96 DRYYAVLYPMVYpmKITGNRAVLALVYIWLHSLIGCLP-----------PLFGWSSLEFDrfkwMCVAAWHKEAG---YT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      193 SCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIpgttsaevkqmrarrKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFR 272
Cdd:cd15214 162 AFWQVWCALLPFVVMLVCYGFIFRVARANQC---------------KAFITILVVLGAFVTTWGPYMVVISTEALWGKNS 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
6TO7_B      273 QASDREavyaafTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15214 227 VSPQLE------TLATWLSFTSAVCHPLIYGLWNKTVRKEL 261
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
39-313 8.50e-12

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 64.73  E-value: 8.50e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLvNLSLADVLAtaiCLPASLL-VDITES--WLFGHALCKVIPYLQAVSVSVAVLTLSF 115
Cdd:cd15114  17 GNALVAWVTGFEAKRSVNAVWFL-NLAVADLLC---CLSLPILaVPIAQDghWPFGAAACKLLPSLILLNMYASVLLLTA 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      116 IALDRWYAICHPlLFKSTARRALGSILG---IWAVSLAIMVPQAAVMEcssVLPE-LAARTrafsVCDERWADDLAPKIY 191
Cdd:cd15114  93 ISADRCLLVLRP-VWCQNHRRARLAWIAcgaAWLLALLLTVPSFIYRR---IHQEhFPEKT----VCVVDYGGSTGVEWA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      192 HSCF-FIVTYLAPLGLMAMAYFQIFRKLWGRQIpgttsaevkqmRARRKTAKMLMVVVLVFALCYLPISVLNVlkrvfgM 270
Cdd:cd15114 165 VAIIrFLLGFLGPLVVIASCHGVLLVRTWSRRR-----------QKSRRTLKVVTAVVVGFFLCWTPYHVVGL------I 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
6TO7_B      271 FRQASDREAVYAAFTFSHWLV----YANSAANPIIYNFLSGKFREQF 313
Cdd:cd15114 228 IAASAPNSRLLANALKADPLTvslaYINSCLNPIIYVVAGRGFRKSL 274
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
40-311 9.63e-12

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 64.46  E-value: 9.63e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 119
Cdd:cd15078  18 NLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNSLFGIVSIMTLTVLAYE 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      120 RWYAICHPLLFKST-ARRAlgsILGIWAVSLAImvpqaavmecsSVLPELAARTRAFSV----CDERW-ADDLAPKIYHS 193
Cdd:cd15078  98 RYIRVVHAKVVNFSwSWRA---ITYIWLYSLAW-----------TGAPLLGWNRYTLEVhglgCSFDWkSKDPNDTSFVL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 CFFIVTYLAPLGLMAMAYFQIF---RKLwgRQIPG-TTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKrVFG 269
Cdd:cd15078 164 LFFLGCLVVPLGIMAYCYGHILyeiRML--RSVEDlQTFQVIKILKYEKKVAKMCLLMISTFLICWMPYAVVSLLV-TSG 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
6TO7_B      270 MFRQASDREAVYAAFtfshwLVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15078 241 YSKLVTPTIAIIPSL-----FAKSSTAYNPVIYIFMIRKFRQ 277
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
39-312 1.14e-11

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 64.40  E-value: 1.14e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVcLAVWRNHHMR-TVTNYFLVNLSLADVLaTAICLPA-SLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 116
Cdd:cd15381  17 ENAFV-LIVFCLHKSScTVAEIYLGNLAAADLL-LVCCLPFwAINISNGFNWPFGEFLCKSVNAVIYMNLYSSIYFLMMV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      117 ALDRWYAICHPLLFKSTARRALGSI--LGIWAVSLAIMVPQAaVMECSSVLPELAARTRAFSVCDERWadDLAPKIYhsc 194
Cdd:cd15381  95 SIDRYLALVKTMSSGRMRRPACAKLncLIIWMFGLLMSTPMI-VFRTVMYFPEYNITACVLDYPSEGW--HVALNIL--- 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVTYLAPLGLMAMAYFQIFRKLwgrqiPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVF--GMFR 272
Cdd:cd15381 169 LNVVGFLIPLSIITFCSTQIIQVL-----RNNKMQKFKEIQTERKATVLVLAVLLMFFICWLPFHIFTFLDTLHklGLIS 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
6TO7_B      273 QASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQ 312
Cdd:cd15381 244 GCRWEDILDIGTQIATFLAYSNSCLNPLLYVIVGKHFRKK 283
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
39-313 1.55e-11

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 63.89  E-value: 1.55e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15298  17 GNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISF 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPqaAVMECSSVlpeLAARTRAFSVCDERWADDLAPKIYHScff 196
Cdd:cd15298  97 DRYFCVTKPLTYpaRRTTKMAGLMIAAAWVLSFVLWAP--AILFWQFV---VGKRTVPDNQCFIQFLSNPAVTFGTA--- 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIfrklwgrqipgtTSAEVKQmrarRKTAKMLMVVVLVFALCYLPISVLNVLKrvfgMFRQASD 276
Cdd:cd15298 169 IAAFYLPVVIMTVLYIHI------------SLASARE----RKVTRTIFAILLAFILTWTPYNVMVLVN----TFCQSCI 228
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      277 REAVYAaftFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15298 229 PDTVWS---IGYWLCYVNSTINPACYALCNATFKKTF 262
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
39-311 1.63e-11

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 63.97  E-value: 1.63e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLV------CLAVWRNhhmrtvTNYFLVNLSLADvLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLT 112
Cdd:cd15378  17 GNTIVilgyifCLKNWKS------SNIYLFNLSVSD-LAFLCTLPMLVYSYSNGQWLFGDFLCKSNRYLLHANLYSSILF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      113 LSFIALDRWYAICHPLLFKSTARR--ALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTRAFSvcderwADDLAPKI 190
Cdd:cd15378  90 LTFISIDRYLLIKYPFREHILQKKrsAVAISLAIWVLVTLELLPILTFIGPNLKDNVTKCKDYASS------GDATNSLI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      191 YHSCFFIVTYLAPLGLMAMAYFQI--FRKLWGRQIPGTTSAEvkqmrarrKTAKMLMVVVLVFALCYLPISVL-NVlkrv 267
Cdd:cd15378 164 YSLFLTVTGFLIPLCVMCFFYYKIalFLKNRNRQLANATSFE--------KPLTLVILAVVIFSVLFTPYHVMrNV---- 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
6TO7_B      268 fgmfRQASDREA----------VYAAFTFSHWLVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15378 232 ----RIASRLDSigvsectliiIKSLYIVTRPIAFLNSVINPVFYFLMGDHFRE 281
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
56-308 2.03e-11

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 63.62  E-value: 2.03e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       56 VTNYFLVNLSLADVLaTAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPL--LFKS 132
Cdd:cd15373  34 ASTTYMFNLAISDTL-YVLSLPLLVYYYADENdWPFSEALCKIVRFLFYTNLYCSILFLLCISVHRFLGVCYPVrsLRWL 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      133 TARRALGSILGIWAVSLAImvpQAAVMECSSVLPELAARTrafsvCDERWADDLAPK--IYHSCFFIVTYLAPLGLMAMA 210
Cdd:cd15373 113 KVRYARIVSVVVWVIVLAC---QSPVLYFVTTSDKGGNIT-----CHDTSSPELFDQfvVYSSVMLVLLFCVPFVVILVC 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      211 YFQIFRKLWGrqipgTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVF-GMFRQASDREAVYAAFTFSHW 289
Cdd:cd15373 185 YALMVRKLLK-----PSAGTSTNSRSKKKSVKMIIIVLAVFILCFLPFHVTRTLYYSFrSMDLSCGTLNAINLAYKVTRP 259
                       250
                ....*....|....*....
6TO7_B      290 LVYANSAANPIIYnFLSGK 308
Cdd:cd15373 260 LASANSCLDPILY-FLAGQ 277
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
40-313 2.44e-11

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 63.22  E-value: 2.44e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 119
Cdd:cd15086  18 NLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGCRWYGFANSLFGIVSLISLAVLSYE 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      120 RWYAICHPLLFKSTA-RRALGSILGIWAVSLAIMVPqaAVMECSSVLPELAARTrafsvCDERWADDLAPKI-YHSCFFI 197
Cdd:cd15086  98 RYCTLLRPTEADVSDyRKAWLGVGGSWLYSLLWTLP--PLLGWSSYGPEGPGTT-----CSVQWTSRSANSIsYIICLFI 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      198 VTYLAPLGLMAMAYFQIFRKLwgRQIPGttsaeVKQMRARRKTAKML-MVVVLV--FALCYLPISVLNVLKrVFGMFRQA 274
Cdd:cd15086 171 FCLLLPFLVMVYCYGRLLYAI--KQVGK-----INKSTARKREQHVLlMVVTMVicYLLCWLPYGVMALLA-TFGKPGLV 242
                       250       260       270
                ....*....|....*....|....*....|....*....
6TO7_B      275 SDREAVYAAFtfshwLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15086 243 TPVASIVPSI-----LAKSSTVVNPIIYVFMNKQFYRCF 276
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
39-313 2.61e-11

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 63.29  E-value: 2.61e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLAtaIC-LPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFI 116
Cdd:cd15921  17 GNSISVYVFLSQYRSQTPVSVLMVNLAISDLLL--VCtLPLRLTYYVLNShWPFGDIACRIILYVLYVNMYSSIYFLTAL 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      117 ALDRWYAICHP--LLFKSTARRALGSILGIWAVslaIMVPQAAVMECSSVLPElAARTRAFSVCDERWADDLapkIYHSC 194
Cdd:cd15921  95 SVFRYLALVWPylYLRVQTHSVAGIICGLIWIL---MGLASSPLLFAKSKQHD-EGSTRCLELAHDAVDKLL---LINYV 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVTYLAPLGLMAMAYFQIFRKLWGrqipgTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNV--LKRVFGMFR 272
Cdd:cd15921 168 TLPVGFVVPFMTVIFCYIFIIKNLLK-----PSPALGRTRPSRRKACALIIISLGIFLVCFLPYHIVRTihLITERQIKE 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
6TO7_B      273 QASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15921 243 SCGYILRVRKAAVITLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
40-312 3.53e-11

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 62.97  E-value: 3.53e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLatAICLPASLLVDITES--WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15379  18 NAVVIGQIWATRQALSRTTIYMLNLATADLL--YVCSLPLLIYNYTQKdyWPFGDFTCRLVRFQFYTNLHGSILFLTCIS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLL--FKSTARRALGSILG-IWAVSLAIMVPQAAVMECSSvlpelaarTRAFSVCderwaDDLAPKIYHSC 194
Cdd:cd15379  96 VQRYLGICHPLAswHKKKGKKLTWLVCGaVWLVVIAQCLPTFVFASTGT--------QRNRTVC-----YDLSPPARSTA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FF-------IVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVKQMRArrKTAKMLMVVVLVFALCYLPisvLNVLKRV 267
Cdd:cd15379 163 YFpygitltRTGFLLPFAARLACYCSMATILCRVVIAVAVVAAPGEKRG--KAARMIIVVAAVFLISFLP---FHYTKTR 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
6TO7_B      268 FGMFRQASD-----REAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQ 312
Cdd:cd15379 238 YLQVRSWDGgpcttRQAFAEAYKRTRPFASMNSVLDPILFYFTQSKFRPR 287
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
39-159 4.15e-11

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 62.66  E-value: 4.15e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15232  17 GNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSELLLLTAMAY 96
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
6TO7_B      119 DRWYAICHPLLFKSTARRAL--GSILGIWAVSLAIMVPQAAVM 159
Cdd:cd15232  97 DRYVAICHPLHYSTIMRKEVcvGLATGVWAIGMLNSAVHTGLM 139
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
55-311 4.53e-11

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 62.58  E-value: 4.53e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       55 TVTNYFLVNLSLADvLATAICLP---ASLLVDITesWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLL-- 129
Cdd:cd15925  34 PPIDVFVFNLALAD-FGFALTLPfwaVESALDFH--WPFGGAMCKMVLTATVLNVYASVFLLTAMSVTRYWVVASAAGpg 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      130 FKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPElaartrafSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAM 209
Cdd:cd15925 111 THLSTFWAKIITLALWAAALLATVPTAIFATEGEVCGV--------ELCLLKFPSNYWLGAYHLQRVVVAFVVPLGVITT 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      210 AYFQIFRKLWGRQIpgttsaEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNvLKRVFGMFRQASDREAVYAAFTF--- 286
Cdd:cd15925 183 SYLLLLSFLQQHKV------NQNNRQRQSVIARSVRLVVASFFLCWFPNHVVT-FWGVLVKFRAVPWNSTFYFIHTYvfp 255
                       250       260
                ....*....|....*....|....*.
6TO7_B      287 -SHWLVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15925 256 vTTCLAHSNSCLNPVLYCLMRREFRQ 281
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
39-310 4.72e-11

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 62.46  E-value: 4.72e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLatAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15174  17 GNSLVVLIYTYYRRRKTMTDVYLLNLAIADLL--FLCTLPFWATAASSGWVFGTFLCKVVNSMYKINFYSCMLLLTCISV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPL-LFKSTARRALGSIL---GIWAVSLAIMVPQ---------AAVMECSSVLPELAARTRAFSVcderwadd 185
Cdd:cd15174  95 DRYIAIVQATkAHNSKNKRLLYSKLvcfFVWLLSTILSLPEilfsqskeeESVTTCTMVYPSNESNRFKVAV-------- 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      186 LAPKIyhscffIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsaevkqMRARR----KTAKMLMVVVLVFALCYLP---I 258
Cdd:cd15174 167 LALKV------TVGFFLPFVVMVICYTLIIHTL---------------LQAKRfqkhKALKVIIAVVTVFVLSQLPynsI 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
6TO7_B      259 SVLNVLKRVFGMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15174 226 LLIKTINAYNITITDCATSQNLDIAGQVTQSIAFLHSCLNPFLYVFVGVRFR 277
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
39-313 5.19e-11

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 62.37  E-value: 5.19e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATaICLPASLLVDITE-SWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15159  17 GNTLALHVICQKRKKINSTTLYLINLAVSDILFT-LALPGRIAYYALGfDWPFGDWLCRLTALLFYINTYAGVNFMTCLS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPqaavMECSSVLPELAARTRAFSVCDERWADDLAPKIYHSCF 195
Cdd:cd15159  96 VDRYIAVVHPLRRhrLRKVKVVRYICVFVWVLVFLQTLP----LLFMPMTKEMGGRITCMEYPNFEKIKRLPLILLGACV 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 fiVTYLAPLGLMAMAYFQIFRKLwgRQIPGTTSAEVKQMRaRRKTAKMLMVVVLVFALCYLPISVlNVLKRVFGMFRQAS 275
Cdd:cd15159 172 --IGFGVPVGIILFCYSQITLKL--CRTAKENPLTEKSGH-HKKACNVILLVLLVFVVCFSPYHL-NIIQFMIRKLLYQP 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
6TO7_B      276 D---REAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15159 246 ScseLKAFKISLQITVCLMNLNCCLDPFIYFFACKGYKKKV 286
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
60-313 5.49e-11

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 62.09  E-value: 5.49e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       60 FLVNLSLADVLATaICLPasLLVD---ITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHP--LLFKSTA 134
Cdd:cd15200  38 YLLSLVVADFFLI-INLP--FRIDyylRNEVWRFGATACQVNLFMLSMNRTASIVFLTAIALNRYLKVVHPhhQLSKASV 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      135 RRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTRAFSVCDERWaddlapkiyHSCFFIVTYLAPLGLMAMAYFQI 214
Cdd:cd15200 115 GCAAKVAAGLWILILLLNIHLLLLDHVQSNSTCLSYDHGTDPSASDRW---------HRILFFLEFFLPLGIILFCIFSI 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      215 FRKLWGRQIPgttsaevKQMRARRkTAKMLMVVVLVFALCYLPISVLNVLKRVfgMFRQASDR------EAVYAAFTFSh 288
Cdd:cd15200 186 ILTLKQRKLA-------KQAGPQR-AVKVLAVIVLVYTVCFLPSILFALASLV--AFKVSQCRsldlctQLFHGSLAFT- 254
                       250       260
                ....*....|....*....|....*
6TO7_B      289 wlvYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15200 255 ---YLNSALDPVLYCFSSPSFLNQS 276
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
39-313 5.50e-11

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 62.07  E-value: 5.50e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPA-SLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15302  17 GNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFyTVYVLNGDYWPLGWVLCDLWLSVDYTVCLVSIYTVLLIT 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKS--TARRALGSILGIWAV-----SLAIMVPQAAVMECSSVLPelaartrafsvcDERWADDLAPKI 190
Cdd:cd15302  97 IDRYCSVKIPAKYRNwrTPRKVLLIIAITWIIpallfFISIFGWQYFTGQGRSLPE------------GECYVQFMTDPY 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      191 YHSCFFIVTYLAPLGLMAMAYFQIFRklwgrqipgttsaevKQMRArRKTAKMLMVVVLVFALCYLPISVLNVlkrVFGM 270
Cdd:cd15302 165 FNMGMYIGYYWTTLIVMLILYAGIYR---------------AANRA-RKALRTITFILGAFVICWTPYHILAT---IYGF 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
6TO7_B      271 FRQASDREAVYaaFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15302 226 CEAPPCVNETL--YTISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
60-306 6.83e-11

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 62.09  E-value: 6.83e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       60 FLVNLSLADVLAtaIC-LPASL-LVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS--TAR 135
Cdd:cd15367  38 YLCNLTVADLLY--IFsLPFWLqYVLQHDNWTYSELLCKICGILLYENIYISIGFLCCISVDRYLAVVHPFRFHAfrTMK 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      136 RALGSILGIWAVSLaimvpqaavMECSSVL--PELAARTRAFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQ 213
Cdd:cd15367 116 AATLVSTVIWLKEL---------MTCVFFFlhGEISKDKENHSVCFEHYPIKAWEHNINYYRFYAGFLFPIFLLSFSYCR 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      214 IFRKLwgRQIPGTTSAEVKQMRarrktaKMLMVVVLVFALCYLPISVLNVLKRVFGmfRQASDREAVYAAFTFSHWLVYA 293
Cdd:cd15367 187 ILRAV--RKSHGTQKSQKIQIK------RLVLSTVVIFLVCFGPYHILLLVRSVFE--RDCNFAEGIFNYYHFSLLLTSF 256
                       250
                ....*....|...
6TO7_B      294 NSAANPIIYNFLS 306
Cdd:cd15367 257 NCVADPVLYCFAS 269
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
39-313 7.53e-11

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 62.01  E-value: 7.53e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMR-TVTNYFLVNLSLADVLaTAICLPASLLVDITESWLFGHALCKVIPY-LQAVSVSVAVLTLSFI 116
Cdd:cd15104  16 GNLLVIVALLKLIRKKdTKSNCFLLNLAIADFL-VGLAIPGLATDELLSDGENTQKVLCLLRMcFVITSCAASVLSLAAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      117 ALDRWYAICHPLLFK--STARRALGSILGIWAVSLAI-MVPQAAVMECSSVLPelaARTRAFSVCDERwaddlapkiYHS 193
Cdd:cd15104  95 AFDRYLALKQPLRYKqiMTGKSAGALIAGLWLYSGLIgFLPLISPQFQQTSYK---GKCSFFAAFHPR---------VLL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 CFFIVTYLAPLGLMAMAYFQIFR--KLWGRQIPGTTSAEVKQMRARR-----KTAKMLMVVVLVFALCYLPISVLnvlkr 266
Cdd:cd15104 163 VLSCMVFFPALLLFVFCYCDILKiaRVHSRAIYKVEHALARQIHPRRtlsdfKAARTVAVLIGCFLLSWLPFQIT----- 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
6TO7_B      267 vfGMFRQASDREAVYAAFTFSHWLV-YANSAANPIIYNFLSGKFREQF 313
Cdd:cd15104 238 --GLVQALCDECKLYDVLEDYLWLLgLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
57-312 1.01e-10

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 61.74  E-value: 1.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       57 TNYFLVNLSLADVLATaICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPL--LFKST 133
Cdd:cd15374  35 TTVYMFHLALSDTLYV-LSLPTLIYYYADHNhWPFGVVACKIVRFLFYANLYCSILFLTCISVHRYVGICHPIraLRWVK 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      134 ARRALGSILGIWAVSLAIMVPQAAVMECSsvlpelaaRTRAFSVCDERWADDLAPKIYHSCFFIVTYL--APLGLMAMAY 211
Cdd:cd15374 114 PRHAYLICASVWLVVTVCLVPNLIFVTTS--------RKDNITLCHDTTRPEEFDHYVHYSSAVMVLLfgIPCLVIVVCY 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      212 FQIFRKLWGRQIPGTTSAevkQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASDR-EAVYAAFTFSHWL 290
Cdd:cd15374 186 GLMARRLCKPRVGSSRQQ---GPSSKKRSLKTIIMVLTVFAICFVPFHITRTLYYVARLLKADCDTlNIINVTYKVTRPL 262
                       250       260
                ....*....|....*....|..
6TO7_B      291 VYANSAANPIIYNFLSGKFREQ 312
Cdd:cd15374 263 ASANSCLDPILYFLAGDKYRRR 284
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
40-311 1.11e-10

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 61.41  E-value: 1.11e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLaTAICLPASLLVDITESWLF-GHALCkvipYLQAVSVS----VAVLTLS 114
Cdd:cd15085  18 NVLVIAVTLKNPQLRNPINIFILNLSFSDLM-MALCGTTIVTVTNYEGYFYlGDAFC----IFQGFAVNyfgiVSLWSLT 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      115 FIALDRWYAICHPL-LFKSTARRALGSILGIWAVSLAIMVpqAAVMECSSVLPELAARTRAFSVCDERWADDLAPKIYH- 192
Cdd:cd15085  93 LLAYERYNVVCKPMgGLKLSTKRGYQGLLFIWLFCLFWAV--APLFGWSSYGPEGVQTSCSIGWEERSWSNYSYLILYFl 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      193 SCFFIvtylaPLGLMAMAYFQIFRKLWG-----RQIPGTTSAEvkqmrARRKTAKMLMVVVLVFALCYLPISVLNVLKrV 267
Cdd:cd15085 171 MCFVI-----PVAIIGFSYGNVLRSLHKlnkkiEQQGGKNCPE-----EEERAVIMVLAMVIAFLICWLPYTVFALIV-V 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
6TO7_B      268 FGMFRQASDREAvyaafTFSHWLVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15085 240 VNPELSISPLAA-----TMPTYFAKTSPVYNPIIYIFLNKQFRE 278
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
39-310 1.13e-10

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 61.35  E-value: 1.13e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVL-ATAICLPASLLVDiteSWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15187  17 GNSLVIWVLVACKKLRSMTDVYLLNLAASDLLfVFSLPFQAYYLLD---QWVFGNAMCKIVSGAYYIGFYSSMFFITLMS 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPL--LFKSTARRALGSILGIWAVSLAIMVP---------QAAVMECSSVLPELAARTRAFSvcderwaddl 186
Cdd:cd15187  94 IDRYLAIVHAVyaLKVRTASHGTILSLALWLVAILASVPllvfyqvasEDGRLQCIPFYPGQGNSWKVFT---------- 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      187 apkiyHSCFFIVTYLAPLGLMAMAYFQIFRKLWGrqipgttsaevKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKR 266
Cdd:cd15187 164 -----NFEVNILGLLIPFSILIFCYHNILRNLRR-----------CHNQNKTKAIKLVFIVVIVFFLFWTPFNVVLFLDS 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
6TO7_B      267 VFGM--FRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15187 228 LHSLhiIDGCQNSQRLTLALHLTETISFTHCCLNPVIYAFVGEKFK 273
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
60-312 1.46e-10

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 60.94  E-value: 1.46e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       60 FLVNLSLADVLaTAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPL--LFKSTARR 136
Cdd:cd15369  38 YMLNLACADLL-FVLLLPFKIAYHFSGNdWLFGEAMCRVVTAAFYCNMYCSILLMTCISVDRFLAVVYPMqsLSWRTLRR 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      137 ALGSILGIWAVSLAIMVPqAAVMECSSVLPELAARTrAFSVCDERWADDLApKIYHSCFFIVTYLAPLGLMAMAYFQIFR 216
Cdd:cd15369 117 ASFTCAAIWLLSIAGVVP-LLLSEQTIQIPDLGITT-CHDVLNEQLLMGYY-VYYFSIFSCLFFFVPLIITTVCYVSIIR 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      217 KLWGRQIPGttsaevkqmRARRKTAKMLM--VVVLVFALCYLPISVLNVLKRVFgmFRQASDREAVYAAFTFSHWLVYAN 294
Cdd:cd15369 194 CLSSSSDVA---------NSSKKTRALFMavAVFCVFVICFGPTNVLLLAHYVR--FAYTSTNDASYFAYLLCVCVGSIS 262
                       250
                ....*....|....*...
6TO7_B      295 SAANPIIYNFLSGKFREQ 312
Cdd:cd15369 263 CCLDPLIYYYGSSQCQKQ 280
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
39-311 2.01e-10

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 60.64  E-value: 2.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15316  17 GNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCDVSFCYASLFHLCFISV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAImvpQAAVMECSSVLPELAARTRAFSvCDERWADDLAPKIYHSCFF 196
Cdd:cd15316  97 DRYIAVTDPLVYptKFTVSVSGICISVSWIFSLTY---SFSVFYTGVNDDGLEELVNALN-CVGGCQIILNQNWVLVDFL 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IvtYLAPLGLMAMAYFQIF--RKLWGRQIPGTTSA--------EVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKR 266
Cdd:cd15316 173 L--FFIPTFAMIILYGKIFlvAKQQARKIEMTSSKaesssesyKDRVARRERKAAKTLGITVIAFLVSWLPYLIDVLIDA 250
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
6TO7_B      267 VFGMFRQAsdreavyAAFTFSHWLVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15316 251 FMNFITPP-------YIYEICCWCAYYNSAMNPLIYALFYPWFRK 288
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
54-312 2.65e-10

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 60.17  E-value: 2.65e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       54 RTVTNYFLVNLSLADVLAtAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS 132
Cdd:cd15115  31 RTVNTIWFLNLAVADLLC-CLSLPFSIAHLLLNGhWPYGRFLCKLLPSIIVLNMFASVFTLTAISLDRFLLVIKPVWAQN 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      133 TARRALGSIL--GIWAVSLAIMVPqaaVMECSSVLPELAARTRAFsvcderwaDDLapKIYHSCFFIVTYLAPLGLMAMA 210
Cdd:cd15115 110 HRSVLLACLLcgCIWILALLLCLP---VFIYRTTVTDGNHTRCGY--------DFL--VAITITRAVFGFLLPLLIIAAC 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      211 YFQIFRKLWGRqipgttsaevKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKrvfgMFRQASDREAVYAAFTFSHWL 290
Cdd:cd15115 177 YSFIAFRMQRG----------RFAKSQSKTFRVIIAVVVAFFVCWAPYHIIGILS----LYGDPPLSKVLMSWDHLSIAL 242
                       250       260
                ....*....|....*....|..
6TO7_B      291 VYANSAANPIIYNFLSGKFREQ 312
Cdd:cd15115 243 AYANSCLNPVLYVFMGKDFKKK 264
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
44-310 3.40e-10

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 60.15  E-value: 3.40e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       44 CLAVWRNHHMRTVTNY-----FLVNLSLADVLATaICLPASLLVDITE-SWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15147  19 CYVLWVFARLYPSKKLneikiFMVNLTIADLLFL-ITLPFWIVYYHNEgNWILPKFLCNVAGCLFFINTYCSVAFLGVIS 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKSTARRALGSILG--IWAVSLAIMVPQAaVMECSSvlpELAARTRAFSVCDERWADDLAPKIYHSCF 195
Cdd:cd15147  98 YNRYQAVTRPIKTAQSTTRKRGIIISvaIWVIIVASASYFL-FMDSTN---TVKIDSGNFTRCFEGYEKDNSKPVLIIHF 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVT--YLAPLgLMAMAYFQIFRKLWGRQIPGTTSAEVKQmRARRktakMLMVVVLVFALCYLPISVLN---VLKrVFGM 270
Cdd:cd15147 174 IIIGlfFLVFL-LILVCNLVIARTLLSQPVQGQRNAGVKR-RALW----MVCTVLAVFVICFVPHHVVQgpwTLA-VLQQ 246
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
6TO7_B      271 FRQASD--REAVYAAFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15147 247 WRYWDCqfRQALNDAHQITLCLMSTNCVLDPVIYCFLTKKFR 288
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
40-304 3.77e-10

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 59.81  E-value: 3.77e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 119
Cdd:cd15366  18 NCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPLWIDYFLHRDNWIHGPESCKLFGFIFYTNIYISIAFLCCISVD 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      120 RWYAICHPLLFkSTARRALGSIlgiwAVSLAIMVPQAAVMECSSVLPELAARTRAFSVCDERWADDLAPKIYHSCFFIVT 199
Cdd:cd15366  98 RYLAVAHPLRF-AKVRRVKTAV----AVSAVVWAIEIGANSAPLFHDELFRDRYNHTFCFEKYPMEDWVAWMNLYRVFVG 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      200 YLAPLGLMAMAYFQIFRKLwgrqiPGTTSAEVKQMRARRKTAKMLMVVVLvfaLCYLPISVLNVLKRVFGMFRQASDR-- 277
Cdd:cd15366 173 FLFPWVLMLFSYRGILRAV-----RGNVSTEQQEKAKIKRLALSLIAIVL---LCFAPYHVLLLSRSVVYLGKPCDCGfe 244
                       250       260
                ....*....|....*....|....*..
6TO7_B      278 EAVYAAFTFSHWLVYANSAANPIIYNF 304
Cdd:cd15366 245 ERVFTAYHVSLALTSLNCVADPILYCL 271
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
54-313 4.08e-10

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 59.78  E-value: 4.08e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       54 RTVTNYFLVNLSLADVLATAIcLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS 132
Cdd:cd15116  31 KTVNTVWFLNLAVADFLFTFF-LPFSIAYTAMDFhWPFGRFMCKLNSFLLFLNMFTSVFLLTVISIDRCISVVFPVWSQN 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      133 --TARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELA-------ARTRAFSVCDERWADDLAPKIYHSCFFIVTYLAP 203
Cdd:cd15116 110 hrSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPSQNNNKiicfnnfSLSGDNSSPEVNQLRNMRHQVMTITRFLLGFLIP 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      204 LGLMAMAYFQIFRKLwgrqipgttsaEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKrvfgMFRQASDREAVYAA 283
Cdd:cd15116 190 FTIIICCYAAIVLKL-----------KRNRLAKSSKPFKIIAAVIVTFFLCWAPYHILNLLE----MEATRSPASVFKIG 254
                       250       260       270
                ....*....|....*....|....*....|
6TO7_B      284 FTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15116 255 LPITSSLAFINSCLNPILYVFMGQDFKKFK 284
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
39-302 4.31e-10

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 59.70  E-value: 4.31e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATaICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15967  17 GNVWGLKSLLANWKKLGNINVFVLNLGLADLLYL-LTLPFLVVYYLKGRkWIFGQVFCKITRFCFNLNLYGSIGFLTCIS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLlfkstarRALGSILGIWAVSLAIMVPQAAVMECssvLPELA-ARTRAFSV-CDERWADDLAPK--IYHS 193
Cdd:cd15967  96 VYRYLAIVHPM-------RVMGRITTTHSVVISALVWLLVVIQS---LPDLFfSKTNSNGTkCFDTTFNDYLESylTYSL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 CFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgTTSAEVKQMrARRKTAKMLMVVVLVFALCYLPISV---LNVLKRVF-- 268
Cdd:cd15967 166 GWTVTGFVIPLLIILGCYGHVVVVL-------CRNNNVDKG-LKQRCLKLVIILIVLFSVCYIPYHVfrnLNLLSRILqk 237
                       250       260       270
                ....*....|....*....|....*....|....*
6TO7_B      269 -GMFRQASDreAVYAAFTFSHWLVYANSAANPIIY 302
Cdd:cd15967 238 qGSCTQWFR--GIYIAHQVSRGLVCLNSALNPLVY 270
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
40-313 6.15e-10

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 59.02  E-value: 6.15e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLpASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 119
Cdd:cd15102  18 NLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYL-ANILLSGARTLRLSPAQWFLREGSMFVALSASVFSLLAIAIE 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      120 RWYAICHPLLFKSTAR-RALGSILGIWAVSLAI-MVPQ------AAVMECSSVLPELAARTRAFSVcderwaddlapkiy 191
Cdd:cd15102  97 RHLTMAKMKPYGASKTsRVLLLIGACWLISLLLgGLPIlgwnclGALDACSTVLPLYSKHYVLFCV-------------- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      192 hsCFFIVTYLAPLGLmamaYFQIFRKLWGRQIPGTTSAEVKQMRARRKTakmLMVVVLVFALCYLPISVLnVLKRVFGMF 271
Cdd:cd15102 163 --TIFAGILAAIVAL----YARIYCLVRASGRKATRASASPRSLALLKT---VLIVLLVFIACWGPLFIL-LLLDVACPV 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
6TO7_B      272 RQAsdrEAVYAAFTFSHwLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15102 233 KTC---PILYKADWFLA-LAVLNSALNPIIYTLRSRELRRAV 270
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
40-313 6.68e-10

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 58.81  E-value: 6.68e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDIT-ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15328  18 NLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSgRRWQLGRSLCQVWISFDVLCCTASIWNVTAIAL 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGS--ILGIWAVSLAImvpqaavmecsSVLPELAARTRAFSVCDERWADDLAPKIYHSCFF 196
Cdd:cd15328  98 DRYWSITRHLEYTLRTRRRISNvmIALTWALSAVI-----------SLAPLLFGWGETYSEDSEECQVSQEPSYTVFSTF 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLaPLGLMAMAYFQIFrklwgrqipgttsaevKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFgmfrqASD 276
Cdd:cd15328 167 GAFYL-PLCVVLFVYWKIY----------------KAAQKEKRAALMVGILIGVFVLCWIPFFLTELISPLC-----SCD 224
                       250       260       270
                ....*....|....*....|....*....|....*..
6TO7_B      277 REAVYAAFTFshWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15328 225 IPPIWKSIFL--WLGYSNSFFNPLIYTAFNKNYNNAF 259
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
39-312 7.58e-10

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 59.04  E-value: 7.58e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADvLATAICLPA-SLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15380  17 GNLFVLFVFLLPRRRLTIAEIYLANLAASD-LVFVLGLPFwAENIRNQFNWPFGNFLCRVISGVIKANLFISIFLVVAIS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKSTARR--ALGSILGIWAVSLAIMVPqAAVMECSSVLPELAARTRAFSVCDERWAddlapKIYHSCF 195
Cdd:cd15380  96 QDRYRTLVHTMTSRRQRSRrqAQVICLLIWVFGGLLSIP-TFLFRSVKHVPDLNISACILLFPHEAWH-----FARRVEL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKLWGRqipgtTSAEVKQMRARR--KTAKMLMVVVLVFALCYLPISVLNVLKRVFGM--F 271
Cdd:cd15380 170 NIVGFLLPLAAIVFFNFHIIASLRER-----TEESRKRCGGLKdtKATRLILTLVLMFLVCWTPYHFFAFLDFLFQVevI 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
6TO7_B      272 RQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQ 312
Cdd:cd15380 245 QGCFWEEFIDLGLQLANFFAFANSCLNPVIYVFAGKLFRTK 285
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
54-311 7.59e-10

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 59.01  E-value: 7.59e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       54 RTVTNYFLVNLSLADvLATAICLPASLlVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS- 132
Cdd:cd15923  32 WTETNIYMTNLAVAD-LLLLISLPFKM-HSYRRESAGLQKLCNFVLSLYYINMYVSIFTITAISVDRYVAIRYPLRAREl 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      133 -TARRALGSILGIWAVSLAIMVPqaavmecSSVLPELAARTRAFSVCDERWADdlapkiyHSCFFIVT--YLAPLGLMAM 209
Cdd:cd15923 110 rSPRKAAVVCAVIWVLVVTISIP-------YFLLDSSNEKTMCFQRTKQTESL-------KVFLLLEIfgFLLPLIIMTF 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      210 AYFQIFRKLWGRQipgttsAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASDREAVYAAFTFSHW 289
Cdd:cd15923 176 CSARVIHTLQKRL------DDVGSRSETKQCIRVIMANLIVFIVCFLPVHVGFFVKFIVGKSYSCDSKLIIHFFLQSAFC 249
                       250       260
                ....*....|....*....|..
6TO7_B      290 LVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15923 250 LSDMNCCLDAFCYYFATKEFRE 271
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
42-304 1.32e-09

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 58.28  E-value: 1.32e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       42 LVCLAVWRNHHMRTVTNYFLVNLSLADVLATAiCLPA-SLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDR 120
Cdd:cd15118  19 LLILWVVGFRLRRTVISIWILNLALSDLLATL-SLPFfTYYLASGHTWELGTTFCRIHSSIFFLNMFVSGFLLAAISLDR 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      121 WYAICHPLLFKS--TARRALGSILGIWAVSLAIMVP-----------QAAVMECSSVLPELAARTRAFSVCDERWADDLA 187
Cdd:cd15118  98 CLLVVKPVWAQNhrNVAAAKKICGVIWAMALINTIPyfvfrdvierkDGRKLCYYNFALFSPSPDNNHPICKQRQEGLAI 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      188 PKiyhscfFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsaevkQMRARRKTA---KMLMVVVLVFALCYLPISVLNVL 264
Cdd:cd15118 178 SK------LLLAFLIPLVIIAVSYAVVSLII--------------RHRCRRRPGrfvRLVVSVVVSFALCWAPYHIFSII 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
6TO7_B      265 KRVfgMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNF 304
Cdd:cd15118 238 EVM--AHNQHSLRPLVIQGLPFATTLAFLNSVLNPVLYVF 275
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
53-306 1.32e-09

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 58.32  E-value: 1.32e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       53 MRTVTNYFLVNLSLADVLATaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS 132
Cdd:cd15156  31 VRNETTTYMINLAISDLLFV-FTLPFRIFYFVQRNWPFGDLLCKISVTLFYTNMYGSILFLTCISVDRFLAIVYPFRSKT 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      133 --TARRALGSILGIWAVSLAIMVPqAAVMECSSVLPELAARTRAFSVCDERWADDLAPKIYHscFFIVTYLAPLGLMAMA 210
Cdd:cd15156 110 lrTKRNAKIVCAAVWLTVLAGSLP-ASFFQSTNNQLNNNSETCFENFSSKTWKTYLSKIVIF--IEIVGFFIPLILNVTC 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      211 YFQIFRKLwgrQIPGTTSaevKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVF--GMFRQASDREAVYAAFTFSH 288
Cdd:cd15156 187 STMVLKTL---RRPNTLS---RSKLNKKKVLKMIFVHLFIFCFCFIPYNVNLVLYSLVrtQTFKNCSVVAAVRTMYPITL 260
                       250
                ....*....|....*...
6TO7_B      289 WLVYANSAANPIIYNFLS 306
Cdd:cd15156 261 CIAVSNCCFDPIVYYFTS 278
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
39-310 1.54e-09

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 57.94  E-value: 1.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATaICLPasLLVDITES---WLFGHALCKVIPYLQAVSVSVAVLTLSF 115
Cdd:cd15194  17 GNAILMGALVFKRGVRRLIDIFISNLAASDFIFL-VTLP--LWVDKEVVlgpWRSGSFLCKGSSYIISVNMYCSVFLLTC 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      116 IALDRWYAICHPLLFKSTARR--ALGSILGIWAVSlaimvpqaavmeCSSVLPELAARTRAFSVCDERWADDLAP---KI 190
Cdd:cd15194  94 MSLDRYLAIVLPLVSRKFRTKhnAKVCCTCVWMLS------------CLLGLPTLLSRELKKYEEKEYCNEDAGTpskVI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      191 YHSCFFIVTYLAPLGLMAMAYFQIFRKLWGR-QIPGttsaevKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFG 269
Cdd:cd15194 162 FSLVSLIVAFFLPLLSILTCYCTIIWKLCHHyQKSG------KHQKKLRKSIKIVFIVVAAFVFSWMPFNLFKALAIASG 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
6TO7_B      270 MFRQASDREAVYA--AFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15194 236 LQVEVTCLPYTLAqlGMEVSAPLAFANSCANPFIYYFFDRYIR 278
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
63-313 1.63e-09

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 57.80  E-value: 1.63e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       63 NLSLADvlatAICLPASLLVDITES----WLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRAL 138
Cdd:cd15922  41 NLALSD----AIITPAAPLLIAYFSlgshWPFGQFLCQLKVFLLSTHMYGSIYFLMLISIHRYVTVVHYNWKSLWKKKSF 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      139 GSIL--GIWAVSLAIMVPQAAVMECSsvlpELAARTRAFSVCDERWADdlAPKIYHSCFFIVTYLAPLGLMAMAYfqifr 216
Cdd:cd15922 117 MKKLclGVWLLLFVQGLPFFFVLKTS----VIDGKTKCLSIHQSELSL--LYFVWNFVLLILGFLLPFGVSLTCY----- 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      217 KLWGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASDR--EAVYAAFTFSHWLVYAN 294
Cdd:cd15922 186 ALLGASIAKMNSNNARGRAMKAKSLQMIGISLVIFIICFVPLHVTRTVGVVVKLFYPESCTllHKVEVAYYISWVLTGVN 265
                       250
                ....*....|....*....
6TO7_B      295 SAANPIIYNFLSGKFREQF 313
Cdd:cd15922 266 CCLDPLLYCFASEKFRKSF 284
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
39-310 2.42e-09

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 57.45  E-value: 2.42e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVcLAVWRNH-HMRTVTNYFLVNLSLADVLATaICLPAsLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15176  17 GNSLV-VAIYAYYkKLKTKTDVYILNLAVADLLLL-FTLPF-WAADAVNGWVLGTAMCKITSALYTMNFSCGMQFLACIS 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVmecsSVLPELAARTRAFSVCDERWADDLAPKIyHSCFFI 197
Cdd:cd15176  94 VDRYVAITKATSRQFTGKHCWIVCLCVWLLAILLSIPDLVF----STVRENSDRYRCLPVFPPSLVTSAKATI-QILEVL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      198 VTYLAPLGLMAMAYFQIFRKLwgrqipgTTSAEVKqmraRRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFR----- 272
Cdd:cd15176 169 LGFVLPFLVMVFCYSRVARAL-------SRTPNVK----KSRALKVLLAVVGVFIVTQLPYNVVKFYRAIDVIYLlitdc 237
                       250       260       270
                ....*....|....*....|....*....|....*...
6TO7_B      273 QASDREAVYAAFTFShwLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15176 238 SMSKTLDIAIQVTES--IALFHSCLNPVLYVFMGASFK 273
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
40-311 3.12e-09

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 57.08  E-value: 3.12e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRT-VTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15219  17 NLLVLLCFLYSAELRKqVPGIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLETFLTSNAMLSMAALSI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTAR-RALGSILGI-WAVSLAIMVPQ---------AAVMECSSVLPELAARTRaFSVcderwaddla 187
Cdd:cd15219  97 DRWIAVVFPLSYTSKMRyRDAALMVGYsWLHSLTFSLVAlflswlgysSLYASCTLHLPREEERRR-FAV---------- 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      188 pkiYHSCFFIVTYLAPLGLMAMAYFQIFRklwgrqipgttsaevkqMRARRKTAKMLMVVVLVFALCYLPISVLNVLkrv 267
Cdd:cd15219 166 ---FTAFFHAFTFLLSLLVLCVTYLKVLK-----------------VRRRQRATKKISIFIGTFVLCFAPYVITRLV--- 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
6TO7_B      268 fgmfrqasdrEAVYAAFTFSHW------LVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15219 223 ----------ELLPFVTINRYWgivskcLTYSKAASDPFVYSLLRQQYRK 262
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
54-313 3.27e-09

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 57.06  E-value: 3.27e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       54 RTVTNYFLVNLSLADvLATAICLPASLLVDITE-SWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS 132
Cdd:cd15119  31 KTVNTLWFLNLAIAD-FVFVLFLPLHITYVALDfHWPFGVWLCKINSFVAVLNMFASVLFLTVISLDRYISLAHPVWSHR 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      133 --TARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTRAFSVCDErwadDLAPKIYHSCF---FIVTYLAPLGLM 207
Cdd:cd15119 110 yrTLKSALILCGIVWLSAAAISGPALYFRDTMELSINVTICFNNFHKHDG----DLIVMRHTILVwvrFFFGFLFPLLTM 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      208 AMAYFQIFRKlwgrqipgttsaeVKQMRARR--KTAKMLMVVVLVFALCYLPISVLNVLKRVfgMFRQASDREAVYAAFT 285
Cdd:cd15119 186 VVCYSLLAIK-------------VKRRTLLIssKFFWTISAVIVAFFVCWTPYHIFSILELS--IHHSSYLHNVLRAGIP 250
                       250       260
                ....*....|....*....|....*...
6TO7_B      286 FSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15119 251 LATSLAFINSCLNPILYVLIGKKFKAHL 278
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
39-313 3.60e-09

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 56.78  E-value: 3.60e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15215  16 GNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFAGVNTIVVVSV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVPqaavmecssvlPELAARTRAF----SVCDERWADDLAPKIYH 192
Cdd:cd15215  96 DRYLAIIHPLSYptKMTPRRGYLLIYGTWIVSVLQSTP-----------PLYGWGQAAFdernALCSVIWGSSYSYTILS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      193 SCFFIVTylaPLGLMAMAYFQIFRKlwgrqipgttsaevkqmrARR----KTAKMLMVVVLVFALCYLPISVLNVLKrvf 268
Cdd:cd15215 165 VVSSFVL---PVIIMLACYSMVFRA------------------ARRcyhcKAAKVIFIIIFSYVLSMGPYSFLSVLA--- 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
6TO7_B      269 gmfrQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15215 221 ----VWVDTQVPQWVISIILWLFFLQCCIHPYIYGYMHKSIKKEF 261
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
39-306 3.64e-09

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 56.67  E-value: 3.64e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd14964  15 GNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGANLASIWTTLVLTY 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTAR--RALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTRAFSVcderwaddlapKIYHSCFF 196
Cdd:cd14964  95 HRYFALCGPLKYTRLSSpgKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNTLTGSCYLICT-----------TIYLTWGF 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 -IVTYLAPLGLMAMAYFQIFRKLwGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLkrvfgmFRQAS 275
Cdd:cd14964 164 lLVSFLLPLVAFLVIFSRIVLRL-RRRVRAIRSAASLNTDKNLKATKSLLILVITFLLCWLPFSIVFIL------HALVA 236
                       250       260       270
                ....*....|....*....|....*....|.
6TO7_B      276 DREAVYAAFTFSHWLVYANSAANPIIYNFLS 306
Cdd:cd14964 237 AGQGLNLLSILANLLAVLASTLNPFIYCLGN 267
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
40-310 7.22e-09

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 55.96  E-value: 7.22e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLaTAICLPASLLVDITESWLFghaLCKVIPYLQAVSVSVAVLTLSFIALD 119
Cdd:cd15920  18 NTLALWVFFLRQQRETSISVYMRNLALADLL-LVLCLPFRVAYQNTAGPLS---FCKIVGAFFYLNMYASILFLSLISLD 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      120 RWYAICHPL-LFK-STARRALGSILGIWAVSLAIMVPqaavmecssvlpeLAARTRAFSVCDERW----ADDLAPKIYHS 193
Cdd:cd15920  94 RYLKIIKPLqQFKiHTVPWSSAASGGVWLLLLACMIP-------------FLFESRNEGPCDNKCfhfrSKGLTAGGINL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 CFFIVTYLAPLgLMAMAYFQIFRKLWGRQIPGTTSAEVK-QMRARRKTakmlMVVVLVFALCYLP---ISVLNVLKRVfG 269
Cdd:cd15920 161 TAVVIFYILSL-LFLYFYAKISHKLYKVSLGNAQQQIKKaSKRAIIKT----FIVLAIFIVCFVPyhiVRVPYVLAQI-D 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
6TO7_B      270 MFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15920 235 VISSLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSFR 275
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
41-308 7.86e-09

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 55.92  E-value: 7.86e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       41 TLVCLAvWRNHHMRTVTNYFLVNLSLADVLAtaICLPASLLVD--ITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd16001  20 TVLWLS-WCRTKRWTCSTIYLVNLAVADLLY--VCSLPLLIVNyaMRDRWPFGDFLCKLVRFLFYTNLYGSILFLTCISV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPL--LFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSvlpeLAARTRAFSVCDERWADDLAPkiYHSCFF 196
Cdd:cd16001  97 HRFLGVCYPIrsLAYRTRRLAVIGSAATWILVVLQLLPTLVYARTGS----INNRTVCYDLTSPDNFGNYFP--YGMVLT 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 IVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEvkqmrARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASD 276
Cdd:cd16001 171 VTGFLIPFLIILLCYCLMIKSLIRSEEAAGVGKA-----ARAKSIRTILLVCGLFALCFVPFHITRTIYLFVRVYLVQDC 245
                       250       260       270
                ....*....|....*....|....*....|....
6TO7_B      277 REAVYAAFTFSHW--LVYANSAANPIIYnFLSGK 308
Cdd:cd16001 246 PLLQFVSLAYKIWrpLVSFNSCINPLLY-FLSGD 278
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
40-311 8.32e-09

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 55.94  E-value: 8.32e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATaicLPASLLVDITES---WLFGHALCKVIPYLQAVSVSVAVLTLSFI 116
Cdd:cd15075  18 NATVIIVTLRHKQLRQPLNYALVNLAVADLGTT---VFGGLLSVVTNAvgyFNLGRVGCVLEGFAVAFFGIAALCTVAVI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      117 ALDRWYAICHPL-LFKSTARRALGSILGIWAVSLAIMVPqaAVMECSSVLPElAARTRafsvCDERW-ADDLAPKIYHSC 194
Cdd:cd15075  95 AVDRLFVVCKPLgTLTFQTRHALAGIASSWLWSLIWNTP--PLFGWGSYQLE-GVMTS----CAPDWySRDPVNVSYILC 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVTYLAPLGLMAMAYFQIFRKLWgrQIPGTTSAEVKQM-RARRKTAKMLMVVVLVFALCYLPISVLNVLkrVFGmfrq 273
Cdd:cd15075 168 YFSFCFAIPFAIILVSYGYLLWTLR--QVAKLGVAEGGSTaKAEVQVARMVVVMVMAFLLCWLPYAAFALT--VVS---- 239
                       250       260       270
                ....*....|....*....|....*....|....*...
6TO7_B      274 ASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15075 240 KPDVYINPLIATVPMYLAKSSTVYNPIIYIFMNKQFRD 277
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
51-312 1.94e-08

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 54.80  E-value: 1.94e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       51 HHMRTV-TNYFLVNLSLADVLaTAICLPASLLVDIT-ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPL 128
Cdd:cd15371  27 FRLRSVcTAIFYANLAISDLL-FCITLPFKIVYHLNgNNWVFGETMCRIITITFYGNMYCSILLLTCISINRYLAIVHPF 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      129 LFKSTARR--ALGSILGIWAVSLAIMVP-----------QAAVMECSSVLPELAARTRAFsvcderwaddlapkIYHSCF 195
Cdd:cd15371 106 IYRSLPKKtyAVLICALVWTIVFLYMLPffilkqtyylkELNITTCHDVLPECEQNSNFQ--------------FYYFIS 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIV-TYLAPLGLMAMAYFQIFRKLwgrqipgttsaevKQMRARR-KTAKMLMVVVLVFALCYLPIsvlNVLKRVFGMFRQ 273
Cdd:cd15371 172 MAVfGFLIPLVITIFCYISIIRTL-------------NAYEHKWfWYVKITALVLIIFTICFAPS---NVILIIHHFNYY 235
                       250       260       270
                ....*....|....*....|....*....|....*....
6TO7_B      274 ASDREAVYAAFTFSHWLVYANSAANPIIYnFLSGKFREQ 312
Cdd:cd15371 236 YFNNDNLYSIYLIALCLGSLNSCLDPFLY-FLMSKWRSQ 273
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
61-313 1.96e-08

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 54.70  E-value: 1.96e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       61 LVNLSLADVLATaICLPASLLVDIT-ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARR--A 137
Cdd:cd15375  39 MLNLALTDLLYV-TSLPFLIYYYINgESWIFGEFMCKFIRFIFHFNLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRrwA 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      138 LGSILGIWAVSLAIMVPqaavMECSSVLPELAARTRAFSVCDERWADDLAPkiYHSCFFIVTYLAPLGLMAMAYFQIFRK 217
Cdd:cd15375 118 IVACAVVWVISLAEVSP----MTFLITTKEKNNRTICLDFTSSDNLNTIWW--YNWILTVLGFLLPLVIVTLCYTRIIYT 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      218 LwgRQIPGTTSAevKQMRARRktakMLMVVVLVFALCYLPISVLNVLKRVFGMFR-QASDREAVYAAFTFSHWLVYANSA 296
Cdd:cd15375 192 L--AKGPHTGSA--SKQKARR----LIILILLVFYVCFLPFHILRVVRIETRLPPvSCCLKHQVHAIYIITRPLAALNTF 263
                       250
                ....*....|....*..
6TO7_B      297 ANPIIYNFLSGKFREQF 313
Cdd:cd15375 264 GNLLLYVVSGDNFQQAF 280
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
39-310 2.20e-08

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 54.37  E-value: 2.20e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLatAIC-LPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFI 116
Cdd:cd15158  17 GNGFALYVLIKTYRQKSAFHIYMLNLAVSDLL--CVCtLPLRVVYYVHKGqWLFGDFLCRISSYALYVNLYCSIYFMTAM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      117 ALDRWYAICHPL--LFKSTARRALGSILGIWavsLAIMVPQAAVMECSSVLPElAARTRAFSVCDERWADDLApKIYHSC 194
Cdd:cd15158  95 SFTRFLAIVFPVqnLNLVTVKKARIVCVGIW---IFVTLTSSPFLMSGSHDTE-TNKTKCFEPPQSNQQLTKL-LVLNYI 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVTYLAPLGLMAMAYFQIFRKLWGRqipgtTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISV-----LNVLKRVfg 269
Cdd:cd15158 170 SLVVGFIIPFLVILICYAMIIRTLLKN-----TMKARKQQSSRKKAIRMIIIVLLAFLVSFMPYHIqrtihLHFLSRK-- 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
6TO7_B      270 mFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15158 243 -DSTCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFR 282
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
53-313 3.01e-08

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 54.16  E-value: 3.01e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       53 MRTVTNYFLVNLSLADVLATaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS 132
Cdd:cd15155  31 MRNETAIFMTNLAVSDLLFV-FTLPFKIFYNFNRHWPFGDSLCKISGTAFLTNIYGSMLFLTCISVDRFLAIVYPFRSRT 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      133 TARRALGSIL--GIWAVSLAIMVpqaavmecSSVLPELAARTRAFSVCDERWADDLApKIYHSCFFI----VTYLAPLGL 206
Cdd:cd15155 110 IRTRRNSAIVcaGVWILVLSGGI--------SASLFSTTNVSNTSTTCFEGFSKSIW-KTYLSKITIfievVGFIIPLLL 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      207 MAMAYFQIFRKLwgrQIPGTTSaevKQMRARRKTAKMLMVVVLVFALCYLP---ISVLNVLKRVFGMFRQASDREAvYAA 283
Cdd:cd15155 181 NLTCSSLVLRTL---RKPATLS---QIGTNKEKVLKMILVHVAIFVVCFVPynsILFLYALVRSQAIANCGVERFA-RTM 253
                       250       260       270
                ....*....|....*....|....*....|
6TO7_B      284 FTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15155 254 YPITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
44-313 3.18e-08

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 54.01  E-value: 3.18e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       44 CLAVWRNHHM---RTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDR 120
Cdd:cd15364  19 CLTLWLTLLQvrrKNVLAVYLFSLSLCELLYLGTLPLWTIYVSNNHKWPWGSLACKITGYIFFCNIYISILLLCCISIDR 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      121 WYAICHPLLFKSTARRALGSIlgiwaVSLAIMVPQAAVMECSSVLPElaARTRAFSVCDERWADDLAPKIYHSCFFIVTY 200
Cdd:cd15364  99 FVAVVYALESRGRRRQRIAAF-----ISFLIFIVVGLVHSPVFIMRE--GQTEGSHTCFETLQMDTQVAGFYYARFCIGF 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      201 LAPLGLMAMAYFQIFRKlwgrqIPGTTSAEVKQmraRRKTAKMLMVVVLVFALCYLPISVLNVLKRV-FGMFRQASD--R 277
Cdd:cd15364 172 AIPLAILIFTNYRIFRS-----IQTSTSLTPHQ---KAKVKYLAIAVIVIFLICFAPYHLVLLVRAIaFSLYPNGMCgfE 243
                       250       260       270
                ....*....|....*....|....*....|....*.
6TO7_B      278 EAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15364 244 ERIYTPSVIFLCLSTVNSVADPIIYVLVSENVRQDI 279
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
60-306 5.25e-08

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 53.25  E-value: 5.25e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       60 FLVNLSLADVLATAICLpasLLVDIT---ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARR 136
Cdd:cd15365  38 YLFNLSLSDLLYIVILP---LWIDYLwngDNWTLSGFVCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPLKFMHLRTI 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      137 ALGSIlgiwaVSLAIMVPQAAVMECSSVLPELAARTRAFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFr 216
Cdd:cd15365 115 RTALS-----VSVAIWLLEICFNAVILTWEDSFHESSSHTLCYDKFPLEDWQARLNLFRICLGYLLPLLIILFCYWKIY- 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      217 klwgrQIPGTTSAEVKQmrARRKTAKMLMVVVLVFALCYLPISVLNVLKRVF--GMFRQASDreaVYAAFTFSHWLVYAN 294
Cdd:cd15365 189 -----QAVRSNQATEDQ--EKKKIFKLLLLITVTFVICFTPYHVVLLIRSIVepCDCRNAKW---LYTLYKITVALTSLN 258
                       250
                ....*....|..
6TO7_B      295 SAANPIIYNFLS 306
Cdd:cd15365 259 CIADPFLYCFVT 270
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
39-312 6.66e-08

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 52.91  E-value: 6.66e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPAslLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd14989  17 GNILILVVNLSFREKMTIPDLYFVNLAVADLILVADSLIE--VFNLNEKYYDIAVLCTFMSLFLQINMYSSIFFLTWMSF 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAI-----CHPLLFKSTARRALGSIlgiWAVS-LAIMVPqaavmecssvlpelaartraFSVCDERWADDLapkiyH 192
Cdd:cd14989  95 DRYIALakvmkSSPLRTMQHARLSCGLI---WMASiSATLLP--------------------FTAVQAQHTGEV-----H 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      193 SCFFIVT----------YLAPLGLMAMAYFQIFRKLwgrqipgTTSAEVKQMRARRKTA-KMLMVVVLVFALCYLPisvL 261
Cdd:cd14989 147 FCFADVReiqwlevtlgFIIPFSIIGLCYSLIVRVL-------VRAQKHRRLRPRRQKAlRMILVVVLVFFICWLP---E 216
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
6TO7_B      262 NVLKRVFGMFRQASDREAVYAAFTFSHWLV--------YANSAANPIIYNFLSGKFREQ 312
Cdd:cd14989 217 NVFISIQLLQGTQEPSESYDESFRHNHPLTghivnlaaFSNSCLNPLIYSFLGETFRDK 275
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
38-311 8.52e-08

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 52.57  E-value: 8.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       38 VGNTLVCLAVWRNHHMRTVTNYFLVNLSLADvLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15183  16 VGNVLVVLVLIQHKRLRNMTSIYLFNLAISD-LVFLFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYLGLYSEIFFIILLT 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVM-----------ECSSVLPELAARtrafsvcdeRWADDL 186
Cdd:cd15183  95 IDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCLYffksqwefthhTCSAHFPRKSLI---------RWKRFQ 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      187 APKIYhscffIVTYLAPLGLMAMAYFQIFRKLWGRqipgttsaevkQMRARRKTAKMLMVVVLVFALCYLPISvLNVLKR 266
Cdd:cd15183 166 ALKLN-----LLGLILPLLVMIICYTGIINILLRR-----------PNEKKAKAVRLIFVITLLFFLLWTPYN-LAAFVS 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
6TO7_B      267 VFGMF---RQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15183 229 AFQDVlftPSCEQSQQLDLALQVTEVIAYTHCCVNPVIYVFVGERFRK 276
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
54-257 8.90e-08

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 52.72  E-value: 8.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       54 RTVTNYFLVNLSLADVLataicLPASLLVDITES---WLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLF 130
Cdd:cd15165  32 WTESTIYMINLALNDLL-----LLLSLPFKMHSSkkqWPLGRTLCSFLESLYFVNMYGSILIIVCISVDRYIAIRHPFLA 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      131 KS--TARRALGSILGIWAVslaimvpqaaVMECSSVLPELAARTRAFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMA 208
Cdd:cd15165 107 KRlrSPRKAAIVCLTIWVF----------VWAGSIPIYSFHDKPTNNTRCFHGFSNKTWSKKVIVVVEEFGFLIPMAVMV 176
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
6TO7_B      209 MAYFQIFRKLWGRQIPGttsaevKQMRARRKTAKMLMVVVLVFALCYLP 257
Cdd:cd15165 177 FCSVQIIRTLLDMRRPE------QPKVKQNKSVKIVLSNLVVFLVCFTP 219
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
38-311 9.80e-08

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 52.52  E-value: 9.80e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       38 VGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15185  16 LGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFL-FTLPFWIHYVRWNNWVFGHGMCKLLSGFYYLGLYSEIFFIILLT 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPLLFKSTARRALGSILGI--WAVSLAIMVPQAAVMECSSVLPELAARTRAFSVCDERWaddlapKIYHSCF 195
Cdd:cd15185  95 IDRYLAIVHAVFALRARTVTFGIITSIitWGLAVLAALPEFIFYETQELFEEFLCSPLYPEDTEDSW------KRFHALR 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLA-PLGLMAMAYFQIFRKLWgrQIPGttsaevkqmRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQA 274
Cdd:cd15185 169 MNIFGLAlPLLIMVICYTGIIKTLL--RCPS---------KKKYKAIRLIFVIMVVFFIFWTPYNLVLLLSAFQSIFFET 237
                       250       260       270
                ....*....|....*....|....*....|....*....
6TO7_B      275 SDREAVY--AAFTFSHWLVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15185 238 DCERSKHldLAMQVTEVIAYTHCCINPVIYAFVGERFRK 276
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
39-310 1.21e-07

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 52.07  E-value: 1.21e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLaTAICLPAsLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15175  17 GNGLVILTYIYFKRLKTMTDIYLLNLALADIL-FLLTLPF-WAASAAKKWVFGEEMCKAVYCLYKMSFFSGMLLLMCISI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALG----SILGIWAVSLAIMVPQAAVmecsSVLPELAARTRAFSVCDERwaDDLAPKIYHSC 194
Cdd:cd15175  95 DRYFAIVQAASAHRHRSRAVFiskvSSLGVWVLAFILSIPELLY----SGVNNNDGNGTCSIFTNNK--QTLSVKIQISQ 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIvTYLAPLGLMAMAYFQIFRKLWgrqipgttsaeVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQA 274
Cdd:cd15175 169 MVL-GFLVPLVVMSFCYSVIIKTLL-----------QARNFEKNKAIKVIIAVVVVFVVFQLPYNSVMLVSTLSSFKGNT 236
                       250       260       270
                ....*....|....*....|....*....|....*....
6TO7_B      275 SDREA---VYAAFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15175 237 TDCDYsknLDFALDVTYSLACFRCCLNPFLYAFIGVKFR 275
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
53-310 1.29e-07

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 52.14  E-value: 1.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       53 MRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLL-FK 131
Cdd:cd15080  31 LRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSnFR 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      132 STARRALGSILGIWAVSLAIMVPqaAVMECSSVLPELAArtrafSVCDERWAdDLAPKIYHSCF----FIVTYLAPLGLM 207
Cdd:cd15080 111 FGENHAIMGVAFTWVMALACAAP--PLVGWSRYIPEGMQ-----CSCGIDYY-TLKPEVNNESFviymFVVHFTIPLIVI 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      208 AMAYfqifrklwGRQIPGTTSAEVKQ------MRARRKTAKMLMVVVLVFALCYLPISvlNVLKRVFgmFRQASDREAVY 281
Cdd:cd15080 183 FFCY--------GRLVCTVKEAAAQQqesattQKAEKEVTRMVIIMVIAFLICWVPYA--SVAFYIF--THQGSDFGPIF 250
                       250       260
                ....*....|....*....|....*....
6TO7_B      282 aaFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15080 251 --MTIPAFFAKSSAVYNPVIYILMNKQFR 277
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
39-310 1.92e-07

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 51.45  E-value: 1.92e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADvLATAICLPASLLVDITES---------WLFGhALCKVIPYLQAVSVSVA 109
Cdd:cd15136  17 GNIIVLLVLLTSRTKLTVPRFLMCNLAFAD-FCMGIYLGLLAIVDAKTLgeyynyaidWQTG-AGCKTAGFLAVFSSELS 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      110 VLTLSFIALDRWYAICHP--LLFKSTARRALGSILGIWAVSLAImvpqaavmecsSVLPELAART-RAFSVCDERWADDL 186
Cdd:cd15136  95 VFTLTVITLERWYAITHAmhLNKRLSLRQAAIIMLGGWIFALIM-----------ALLPLVGVSSySKTSICLPFETETP 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      187 APKIYhSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTtsaevkqmRARRKTAKMLMVVVLVFALCYLPISVLNvLKR 266
Cdd:cd15136 164 VSKAY-VIFLLLFNGLAFLIICGCYIKIYLSVRGSGRAAN--------SNDTRIAKRMALLVFTDFLCWAPIAFFG-LTA 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
6TO7_B      267 VFGMFRQASDREAVYAAFTFShwlvyANSAANPIIYNFLSGKFR 310
Cdd:cd15136 234 AFGLPLISVSNAKILLVFFYP-----LNSCANPFLYAIFTKQFR 272
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
54-313 1.97e-07

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 51.71  E-value: 1.97e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       54 RTVTNYFLVNLSLADVLATAIcLP---ASLLVDitESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLF 130
Cdd:cd15120  31 RTVNTLWFLHLILSNLIFTLI-LPfmaVHVLMD--NHWAFGTVLCKVLNSTLSVGMFTSVFLLTAISLDRYLLTLHPVWS 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      131 KS--TARRALGSILGIWAVSLAIMVPQAAVME----------CSSvlpELAARTRAFSVCDERWADdlapKIYHSCF--- 195
Cdd:cd15120 108 RQhrTNRWASAIVLGVWISAILLSIPYLAFREtrldekgktiCQN---NYALSTNWESAEVQASRQ----WIHVAMFvfr 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsaEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQAS 275
Cdd:cd15120 181 FLLGFLLPFLIITFCYVRMALKM-----------KERGLARSSKPFKVMFTAVVSFFVCWLPYHLHSGLVLTRGRPPSLT 249
                       250       260       270
                ....*....|....*....|....*....|....*...
6TO7_B      276 DREAVYAAFTFSHwlvyaNSAANPIIYNFLSGKFREQF 313
Cdd:cd15120 250 DITLLLTVGTTCF-----NTCFTPVLYLFVGENFKKVL 282
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
45-311 2.16e-07

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 51.68  E-value: 2.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       45 LAVWRNHHMRTVTNY--FLVNLSLADVLATaICLPASLLVDIT-ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRW 121
Cdd:cd15924  20 LAMWIFFHIPSKSSFiiYLKNTVVADLLMI-LTFPFKILSDAGlGPWQLRTFVCRVTSVLFYFTMYTSIVFLGLISIDRY 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      122 YAICHPLLFKSTARRALGSILGI--WAVSLAIMVPQA----------AVMECSSVLPELAARTRAFSvcderwaddlapk 189
Cdd:cd15924  99 LKIVRPFKTSFPKSVSFAKILSVvvWALMFLLSLPNMiltnqqprekNVKKCSFLKSELGLKWHEIV------------- 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      190 iyhSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAEVkqmrARRKTAKMLMVVVLVFALCYLPISVLnvlkRVFG 269
Cdd:cd15924 166 ---NYICQVIFWIVFLLMIVCYTAITKKVYRSYRRVFRSSSS----RRKKSNVKIFIIVAVFFVCFVPYHFA----RIPY 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
6TO7_B      270 MFRQASDREAVYAAFT------FSHWLVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15924 235 TLSQTRDVFDCTAENIlfyvkeATLFLSALNVCLDPIIYFFLCKSFRE 282
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
39-154 2.93e-07

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 51.49  E-value: 2.93e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLL-VDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15217  17 GNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVsIRNGSAWTYSVLSCKIVAFMAVLFCFHAAFMLFCIS 96
                        90       100       110
                ....*....|....*....|....*....|....*....
6TO7_B      118 LDRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVP 154
Cdd:cd15217  97 VTRYMAIAHHRFYskRMTFWTCIAVICMVWTLSVAMAFP 135
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
39-148 2.96e-07

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 51.07  E-value: 2.96e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15235  18 GNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDSFLLAVMAY 97
                        90       100       110
                ....*....|....*....|....*....|..
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVS 148
Cdd:cd15235  98 DRYVAICHPLHYATvmSPKRCLLLVAGSWLLS 129
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
39-154 7.83e-07

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 50.03  E-value: 7.83e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASL-LVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15218  17 GNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFtSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCIS 96
                        90       100       110
                ....*....|....*....|....*....|....*....
6TO7_B      118 LDRWYAICHPLLF--KSTARRALGSILGIWAVSLAIMVP 154
Cdd:cd15218  97 VTRYLAIAHHRFYtkRLTFWTCLAVICMVWTLSVAMAFP 135
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
39-313 8.46e-07

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 49.55  E-value: 8.46e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLV-NLSLADVLaTAICLPASLLVDI---------TESWLfGHALCKVIPYLQAVSVSV 108
Cdd:cd14980  17 GNILVIIWHISSKKKKKKVPKLLIiNLAIADFL-MGIYLLIIAIADQyyrgryaqySEEWL-RSPPCLLACFLVSLSSLM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      109 AVLTLSFIALDRWYAICHPLLFKS-TARRALGSILGIWAVSLAImvpqAAVMECSSVLPELAARTRAF-SVCDERWADDL 186
Cdd:cd14980  95 SVLMMLLITLDRYICIVYPFSNKRlSYKSAKIILILGWLFSIIF----AAIPILYSINQPGDNRLYGYsSICMPSNVSNP 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      187 APKIYHSCFFIVTYLAPLgLMAMAYFQIFRKLwgRQipGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLkr 266
Cdd:cd14980 171 YYRGWLIAYLLLTFIAWI-IICILYILIFISV--RK--SRKSARRSSSKRDKRIAIRLALILITDLICWLPYYIVIFS-- 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
6TO7_B      267 vfGMFRQAS-DREAVYAAFTFSHWLvyaNSAANPIIYNFLSGKFREQF 313
Cdd:cd14980 244 --GLLTSTEiDIHVLQFIAILALPL---NSAINPYLYTLTTPTFKRDF 286
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
38-310 9.25e-07

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 49.75  E-value: 9.25e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       38 VGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATaICLPASLLVDITEsWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15184  16 VGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFL-LTLPFWAHYAANE-WVFGNAMCKLLTGLYHIGFFSGIFFIILLT 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPlLFKSTARRALGSILG---IWAVSLAIMVP---------QAAVMECSSVLPelaARTRAFsvcderWADD 185
Cdd:cd15184  94 IDRYLAIVHA-VFALKARTVTFGVVTsvvTWVVAVFASLPgiiftksqkEGSHYTCSPHFP---PSQYQF------WKNF 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      186 LAPKIYhscffIVTYLAPLGLMAMAYFQIFRklwgrqipgtTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISV---LN 262
Cdd:cd15184 164 QTLKMN-----ILGLVLPLLVMIICYSGILK----------TLLRCRNEKKRHKAVRLIFTIMIVYFLFWAPYNIvllLN 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
6TO7_B      263 VLKRVFGMfRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15184 229 TFQEFFGL-NNCSSSNRLDQAMQVTETLGMTHCCINPVIYAFVGEKFR 275
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
40-310 1.11e-06

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 49.45  E-value: 1.11e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNY-FLVNLSLADVLATAIclpasLLVDITESWLFGHALCKVIPYLQAVSVSV----AVLTLS 114
Cdd:cd15341  18 NVAVLYLILSSPKLRRKPSYlFIGSLALADFLASVV-----FACSFVDFHVFHGVDSSAIFLLKLGGVTMsftaSLGSLL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      115 FIALDRWYAICHPLLFKS--TARRALGSILGIWAVSLAImvpqaavmecsSVLPELAART-RAFSVCDERWAddLAPKIY 191
Cdd:cd15341  93 LMAFDRYVCIYYPSEYKAlvTRKRALVALAVMWVLTALI-----------AYLPLMGWNCcPLNSPCSELFP--LIPNDY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      192 HSCFFIVTYLAPLGLMamayFQIFRKLWgRQIPGTTSAEVKQMRARRKTAKM---------LMVVVLVFALCYLPISVLN 262
Cdd:cd15341 160 LLSWLLLVAILLSGII----YTYGHVLW-KAHKHVVYMEKHQDQQGPGNARMrldvrlaktLGLVLAVLLICWSPVLALM 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
6TO7_B      263 VLKRVFGMFRQasdreaVYAAFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15341 235 MHSLFTSLSDH------IKKAFAFCSTLCLVNSMVNPIIYALRSRELR 276
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
54-312 1.29e-06

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 49.05  E-value: 1.29e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       54 RTVTNYFLVNLSLADvLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS- 132
Cdd:cd15166  32 RTTVTVYMMNVALVD-LIFILSLPFRMVYYAKDEWPFGDYFCRILGALTVFYPSIALWLLAFISADRYMAIVQPKHAKEl 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      133 -TARRALGSILGIWAVSLAIMVPQAavmecssVLPELAARTRAFSVCdERWADDLAPKIYHSCFF---IVTYLAPLGLMA 208
Cdd:cd15166 111 kNTPKAVLACVGVWIMTLASTFPLL-------FLYEDPDKASNFTTC-LKMLDIIHLKEVNVLNFtrlIFFFLIPLFIMI 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      209 MAYFQIFRKLwgrqIPGTTSAevKQMRARRKTAKMLMVVVLVFALCYLPISVLnvlkRVFGMFRQASDREAVYAAFTfsH 288
Cdd:cd15166 183 GCYLVIIHNL----VHGRTSK--LKPKVKEKSIRIIITLIVQVLVCFVPFHIC----FAFLMLQNGDNSYNPWAAFT--T 250
                       250       260
                ....*....|....*....|....
6TO7_B      289 WLVYANSAANPIIYNFLSGKFREQ 312
Cdd:cd15166 251 FLMNLSTCLDVILYYIVSKQFQAR 274
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
40-310 1.38e-06

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 49.06  E-value: 1.38e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 119
Cdd:cd15077  18 NVLTIICTIKYKKLRSHLNYILVNLAVANLIVVCFGSTTAFYSFSQMYFVLGPLACKIEGFTATLGGMVSLWSLAVVAFE 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      120 RWYAICHPL---LFKSTarRALGSILGIWAVSLAIMVPqaAVMECSSVLPE--LAARTRAFSVCDERWADDlapkIYHSC 194
Cdd:cd15077  98 RFLVICKPLgnfTFRGT--HAIIGCIATWVFGLAASLP--PLFGWSRYIPEglQCSCGPDWYTTNNKWNNE----SYVMF 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      195 FFIVTYLAPLGLMAMAYFQIFRKLwgRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNvlkrVFGMFRQA 274
Cdd:cd15077 170 LFCFCFGVPLSIIVFSYGRLLLTL--RAVAKQQEQSASTQKAEREVTKMVVVMVLGFLVCWLPYASFA----LWVVTNRG 243
                       250       260       270
                ....*....|....*....|....*....|....*.
6TO7_B      275 SDREAVYAafTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15077 244 EPFDLRLA--SIPSVFSKASTVYNPVIYVFMNKQFR 277
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
39-128 1.46e-06

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 49.11  E-value: 1.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPaSLLVDIteswlfgHALCKVIPYLQAVSVSVAVLT------ 112
Cdd:cd15234  17 GNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVP-KMLVNI-------QTQSKSISYTGCLTQMCFFLLfggldn 88
                        90
                ....*....|....*...
6TO7_B      113 --LSFIALDRWYAICHPL 128
Cdd:cd15234  89 flLAVMAYDRYVAICHPL 106
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
40-313 1.80e-06

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 48.68  E-value: 1.80e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNY-FLVNLSLADVLATAICLPASLL------VDITESWLFghalcKVIPYLQAVSVSVAVLT 112
Cdd:cd15099  18 NILVLLTILSSTALRRRPSYlFIGSLALADMLASVIFTISFLDfhvfhqRDSRNLFLF-----KLGGVTMAFTASVGSLL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      113 LSfiALDRWYAICHPLLFKS--TARRALGSILGIWAVSLAImvpqaavmecsSVLPELAARTRAF-SVCDerwadDLAPK 189
Cdd:cd15099  93 LT--ALDRYLCIYQPSNYKLlvTRTRAKVAILLMWCVTIII-----------SFLPLMGWRCKTWdSPCS-----RLFPY 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      190 I--YHSCFFIVTYLAPLGLMAMAYFQIFRK-------LWGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISV 260
Cdd:cd15099 155 IdrHYLASWTGLQLVLLFLIIYAYPYILWKahrheanMGGPKLGRQQVKGQARMRMDIRLAKTLSLILLVLAICWLPVLA 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
6TO7_B      261 LNVLKRVFGMfrqasdREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15099 235 FMLVDVRVTL------TNKQKRMFAFCSMLCLVNSCVNPIIYALRSRELRGAM 281
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
38-313 1.99e-06

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 48.55  E-value: 1.99e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       38 VGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVL-ATAICLPASLLVdITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 116
Cdd:cd15157  16 VGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMfVSTLPFRADYYL-MGSHWVFGDIACRIMSYSLYVNMYCSIYFLTVL 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      117 ALDRWYAICHPL-LFKSTarralgSILGIWAVSLAIMVpqaAVMECSSVLPEL-AARTRAFSVCDERWADDLAP-KIYHS 193
Cdd:cd15157  95 SIVRFLAIVHPFkLWKVT------SIKYARILCAVIWI---FVMAASSPLLSKgTSKYNSQTKCLDLHPSKIDKlLILNY 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 CFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTtsaevkQMRARRKTAKMLMVVVL-VFALCYLPISVLNVLKRVFGMFR 272
Cdd:cd15157 166 IVLVVGFILPFCTLSICYILIIKALLKPRVPQS------KLRVSHKKALLTIIITLiLFLLCFLPYHILRTVHLMQWSEG 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
6TO7_B      273 QASDReaVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15157 240 QCNLR--LHKAVVITLCLAAANSCLDPLLYYFAGENFKERL 278
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
40-313 2.03e-06

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 48.64  E-value: 2.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWL------FGHALCKVIPYLQAVSVSVAVLTL 113
Cdd:cd15103  18 NILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYlvprdsFEQHIDNVIDSMICSSLLASICSL 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      114 SFIALDRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVMECSSVLpelaartrafsVCderwaddlapkiy 191
Cdd:cd15103  98 LAIAVDRYITIFYALRYHSimTVRRAGVIITAIWVFCTVCGILFIIYSDSVPVI-----------IC------------- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      192 hscfFIVTYLAPLGLMAMAYFQIF--RKLWGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPIsVLNVLKRVFG 269
Cdd:cd15103 154 ----LISMFFAMLVLMASLYVHMFllARSHVKKIAALPGQRSTRQRANMKGAVTLTILLGVFIFCWAPF-FLHLTLMISC 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
6TO7_B      270 mfrqasdREAVYAAFTFSHW-----LVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15103 229 -------PSNPYCACYMSHFnvyliLIMCNSVIDPLIYAFRSQELRKTF 270
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
60-311 2.61e-06

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 48.31  E-value: 2.61e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       60 FLVNLSLADVLATaICLPASLLVDI-TESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRAL 138
Cdd:cd15149  37 YLKNIVFADLLMS-LTFPFKILSDVeLGPWQLNVIVCRYSAVIFYLNMYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVGY 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      139 GSILG--IWAVSLAIMVPQAAVMECSSVLPELAARTRAFSVCDERWaDDLAPKIYHSCFFIVTYlaplgLMAMAYFQIFR 216
Cdd:cd15149 116 SKALSvvVWMLMAVLSVPNIILTNQSFHEANYTKCARLKSELGIQW-HKASNYICVSIFWVVFL-----LLIIFYVAISR 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      217 KLWGRQIPGTTSAEVkqmrARRKTAKMLMVVVLVFALCYLPISVLNV--LKRVFGMFRQASDREAVYAAFTFSHWLVYAN 294
Cdd:cd15149 190 KIYKSNQKFRRNSTN----MKAKSSRNIFSILFVFFVCFVPYHALRIpyTLSQTGADYSCQSKTILYYMKEFTLLLSAAN 265
                       250
                ....*....|....*..
6TO7_B      295 SAANPIIYNFLSGKFRE 311
Cdd:cd15149 266 VCLDPIIYFFLCQPFRE 282
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
55-311 2.93e-06

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 48.03  E-value: 2.93e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       55 TVTNYFLVNLSLADvlataICLPASLLVDItesWLFGH-----ALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLL 129
Cdd:cd15164  33 TETRVYMINLAVAD-----CCLLFSLPFVL---YFLKHswpddELCLVLQSIYFINRYMSIYIITAIAVDRYIAIKYPLK 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      130 FKS--TARRALGSILGIWAVSLAIMVPQAAVMECSSvlpelaartrafSVCDERwaDDLAPKIYHSCFFIVTYLAPLGLM 207
Cdd:cd15164 105 AKSlrSPRKAALTCGLLWVLVIISVSLRLAWEEQEE------------NFCFGK--TSTRPSKRTLIFSLLGFFIPLIIL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      208 AMAYFQIFRKLwgRQIPGTTSAEVKQMrarRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQA-SDREAVYAAFTF 286
Cdd:cd15164 171 SFCSIQVIRSL--KKKKKTNPHEEKLI---QKAIYIVSANLIVFIVCFLPLHIGLLVRFVMESNKAScSLIQNIRNFIYV 245
                       250       260
                ....*....|....*....|....*
6TO7_B      287 SHWLVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15164 246 ASCLANANCCLDAICYYFVAKEFQE 270
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
54-310 3.04e-06

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 47.86  E-value: 3.04e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       54 RTVTNYFLVNLSLADVLATaICLPAsLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS- 132
Cdd:cd15188  33 KKMTEVYLLNLAVSDLLFL-VTLPF-WAMYVAWHWVFGSFLCKFVSTLYTINFYSGIFFVSCMSLDKYLEIVHAQSPHRl 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      133 -TARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAARTRAFSVCDERWaddlapKIYHSCFFIVT-YLAPLGLMAMA 210
Cdd:cd15188 111 rTRRKSLLVLVAVWVLSIALSVPDMVFVQTHHTNNGVWVCHADYGGHHTIW------KLVFQFQQNLLgFLFPLLAMVFF 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      211 YFQIFRKLWGRQIPGttsaevkqmraRRKTAKMLMVVVLVFALCYLPISVLNVLKRV--FGMFRQASDREAVYAAFTFSH 288
Cdd:cd15188 185 YSRIACVLTRLRPPG-----------QGRALRFVAALVVVFFVLWFPYNLTLFLHSLqdLHVIGNCERSRHLDYALQVTE 253
                       250       260
                ....*....|....*....|..
6TO7_B      289 WLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15188 254 SLAFVHCCLNPLLYAFVSKRFR 275
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
39-159 4.27e-06

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 47.48  E-value: 4.27e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPaSLLVDIteswLFGHalcKVIPY----LQAVSV----SVAV 110
Cdd:cd15912  17 GNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIP-KMLANL----LSGK---KTISFagcfAQSFFYfflgTTEF 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
6TO7_B      111 LTLSFIALDRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVM 159
Cdd:cd15912  89 FLLAVMSFDRYVAICNPLHYPTimNSRVCLQLVLGSWVGGFLLILPPTILV 139
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
40-310 5.08e-06

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 47.09  E-value: 5.08e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFG------HALCKVIPYLQAVSVSVAVLTL 113
Cdd:cd15351  18 NILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVcrapmlQHMDNVIDTMICSSVVSSLSFL 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      114 SFIALDRWYAICHPLLFKS--TARRALGSILGIWAVSLAimvpqaavmecSSVLPELAARTRAFSVCderwaddlapkiy 191
Cdd:cd15351  98 GAIAVDRYITIFYALRYHSimTLQRAVNAIAGIWLASTV-----------SSTLFIVYYNSNAVILC------------- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      192 hscfFIVTYLAPLGLMAMAYFQIFrkLWGRQIPGTTSAEVKQMRARRKTAKM-----LMVVVLVFALCYLP-----ISVL 261
Cdd:cd15351 154 ----LIVFFLFMLVLMLVLYIHMF--ILACRHSQSISSQQRRQCPHQQTASLkgaitLTILLGIFFLCWGPfflhlTLIV 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
6TO7_B      262 NVLKRVFGMfrqasdreAVYAAFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15351 228 TCPTHPFCL--------CYFKYFNLFLILIICNSIIDPLIYAFRSQELR 268
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
39-257 6.46e-06

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 47.00  E-value: 6.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATaICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15148  17 GNLLALWVFLFIHRKRNSVRIFLINVAIADLLLI-ICLPFRILYHVNNNqWTLGPLLCKVVGNLFYMNMYISIILLGFIS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAIchpllFKSTARRALG----SILG---IWAVSLAIMVPQAAVMECSSvlpelaARTRAF---SVCDERWaddla 187
Cdd:cd15148  96 LDRYLKI-----NRSSRRQKFLtrkwSIVAcgvLWAVALVGFVPMIVLTEKNE------ESTKCFqykDRKNAKG----- 159
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
6TO7_B      188 pKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLW--GRQIPGTTSAEVKQmrarrKTAKMLMVVVLVFALCYLP 257
Cdd:cd15148 160 -KAIFNFLIVAMFWLVFLLLILSYGKIAKKLLriSRDKPDFPNAAKYN-----RTARKSFFVLFIFTVCFVP 225
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
95-311 6.52e-06

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 47.17  E-value: 6.52e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       95 CKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPL-LFKSTARRALGSILGIWAVSLAI-MVPqaavMECSSVLPELAART 172
Cdd:cd15965  80 CQLVGSLAILSTEVSVLLLTYLTLEKYICIVYPFrCLTPGKCRTITILILIWIIGFIIaFIP----LSNKEFFRNYYGTN 155
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      173 RAFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLwgrQIPGTTSAEVK-QMRARRKTAKMLMVVVLVF 251
Cdd:cd15965 156 GVCFPLHSEQPESTGAQIYSVVIFLGLNLAAFIIIVFSYGSMFYSI---HQTAIMATEISnHIKKEMTLAKRFFFIVFTD 232
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
6TO7_B      252 ALCYLPISVLNVLKRVfgmfrqasdreAVYAAFTFSHWLVY----ANSAANPIIYNFLSGKFRE 311
Cdd:cd15965 233 ALCWIPIFILKLLSLL-----------QVEIPGTISSWVVIfilpINSALNPILYTLTTRPFKE 285
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
39-138 7.99e-06

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 46.63  E-value: 7.99e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLP---ASLLVDiteswlfghalCKVIPYLQAVS---VSVAVLT 112
Cdd:cd15429  17 GNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPqmlAHFLAE-----------HKTISFASCVAqlfISLALGG 85
                        90       100       110
                ....*....|....*....|....*....|.
6TO7_B      113 LSFI-----ALDRWYAICHPLLFKSTARRAL 138
Cdd:cd15429  86 TEFIllavmAYDRYVAVCHPLRYTVIMSGGL 116
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
41-133 1.14e-05

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 46.26  E-value: 1.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       41 TLVCLavwrNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDR 120
Cdd:cd15405  23 TLICL----NSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISECYVLTAMAYDR 98
                        90
                ....*....|...
6TO7_B      121 WYAICHPLLFKST 133
Cdd:cd15405  99 YVAICNPLLYTVT 111
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
40-310 1.27e-05

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 45.97  E-value: 1.27e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATaiclpASLLVDITESWLFGHALCKVIPYLQA----VSVSVAVLTLSF 115
Cdd:cd15348  18 NLIVLLALWRNKKFHSPMFYLLGSLTLSDLLAG-----AAYAANILMSGANTLKLTPALWFLREggvfITLTASVFSLLA 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      116 IALDRWYAICHPLLFKSTAR-RALGSILGIWAVSLAIMVPQA-------AVMECSSVLPelaartrafsvcderwaddLA 187
Cdd:cd15348  93 IAIERHITMVRMKPYPGDKRgRMFLLIGAAWLVSILLGVLPIlgwnclgNLDACSTVLP-------------------LY 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      188 PKIYhSCFFIVTYLAPLGLMAMAYFQIFR--KLWGRQIPGTTSAEVKQMRARRKTA--KMLMVVVLVFALCYLPISVLNV 263
Cdd:cd15348 154 AKSY-ILFCITVFLAILAAIVVLYARIYRivKANSQRLGALPTRKGRARRSQKYLAllKTVTIVLGTFVACWLPLFLLLL 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
6TO7_B      264 LKrvfgMFRQASDREAVYAAFTFSHwLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15348 233 LD----VSCPAQACPVLLKADYFLG-LAMINSLLNPIIYTLTSRDMR 274
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
45-311 1.63e-05

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 45.93  E-value: 1.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       45 LAVWRNHHMRTVTNY--FLVNLSLADVLATaICLPASLLVDI-TESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRW 121
Cdd:cd15151  20 VAAWIFFHIPSTSTFivYLKNTLVADLIMT-LMLPFKILSDSgLGPWQLRAFVCRFSAVVFYITMYISIILLGLISFDRY 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      122 YAICHPLLFKSTARRALGSILGI--WAVSLAIMVPQAavmecssVLPELAARTRAFSVCDE-------RWADdlapKIYH 192
Cdd:cd15151  99 LKIVRPFGKSWVQRVRFAKILSGavWLVMFLLSVPNM-------ILSNKPATPISVKKCASlksplglKWHE----VVNY 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      193 SCFFIvtYLAPLGLMAMAYFQIFRKLWgrqiPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNV---LKRVfG 269
Cdd:cd15151 168 ICQFI--FWGVFALMVLFYTIISKKVY----ESYKKSRSKDNKASKKTKAKVFIIVAVFFVCFAPFHFVRVpytLSQT-G 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
6TO7_B      270 MFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFRE 311
Cdd:cd15151 241 KITDCQLQNLLYIAKEITLWLAATNVCLDPLIYIFLCKSFRQ 282
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
39-310 1.73e-05

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 45.67  E-value: 1.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADV-LATAICLPASllVDI-TESWLFGHAL-------CKVIPYLQAVSVSVA 109
Cdd:cd15964  17 GNVFVLLILLTSHYKLTVPRFLMCNLAFADFcMGIYLLLIAS--VDLhTRSEYYNHAIdwqtgpgCNTAGFFTVFASELS 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      110 VLTLSFIALDRWYAICHPLLF--KSTARRALGSILGIWAVS-LAIMVPQAAVMECSSVlpelaartrafSVCDERWADDL 186
Cdd:cd15964  95 VYTLTVITLERWYAITFAMRLdrKIRLRHASAIMLGGWVFCfLLALLPLVGVSSYAKV-----------SICLPMDTETP 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      187 APKIYHSCFFIVTYLAPLgLMAMAYFQIFRKLwgrqipgtTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKR 266
Cdd:cd15964 164 LAQAYIVFVLMLNIIAFV-IICACYIKIYITV--------RNPQYKSGDKDTKIAKRMAVLIFTDFICMAPISFYALSAI 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
6TO7_B      267 VFGMFRQASDREAVYAAFtfshwlVYANSAANPIIYNFLSGKFR 310
Cdd:cd15964 235 LNKPLITVSNSKILLVLF------YPLNSCANPFLYAIFTKAFR 272
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
60-312 1.80e-05

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 45.55  E-value: 1.80e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       60 FLVNLSLADvLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRalg 139
Cdd:cd15153  38 FMINLAVAD-LAHVLSLPLRIHYYIQHTWPFGRFLCLLCFYLKYLNMYASICFLTCISIQRCFFLLHPFKARDWKRR--- 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      140 silgiWAVSLAIMVPQAAVMECssvLPELAARTRAFSVCDERWADDLAPKIYHSCFFIVT--------YLAPLGLMAMAY 211
Cdd:cd15153 114 -----YDVGISAAVWIVVGLAC---LPFPLLRSKSLSNNNRSCFADLGMKKLNFGAAIAMmtvaelfgFVIPLFIIAWCT 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      212 FQIFRKLW--GRQIPGTTSaevkqmraRRKTAKMLMVVVLVFALCYLPISVlNVLKRVFGMFRQASDREAVYAAFTF--- 286
Cdd:cd15153 186 WKTENSLRqrNKQQQSTSE--------KQKALRMVRMCAAVFFICFAPYHI-NFLFYLMVSESIITNCEVSQVILQFhpi 256
                       250       260
                ....*....|....*....|....*.
6TO7_B      287 SHWLVYANSAANPIIYNFLSGKFREQ 312
Cdd:cd15153 257 SLCLASLNCCLDPILYYFMTSEFQDQ 282
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
39-128 1.93e-05

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 45.30  E-value: 1.93e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPaSLLVDI-TESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15918  17 GNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVP-KMLVNIqTQSKSISYAGCLTQMYFFLLFGDLDNFLLAVMA 95
                        90
                ....*....|.
6TO7_B      118 LDRWYAICHPL 128
Cdd:cd15918  96 YDRYVAICHPL 106
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
39-154 2.04e-05

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 45.55  E-value: 2.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESwlfghalcKVIPYLQAVS-----VSVAV--- 110
Cdd:cd13954  17 GNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGD--------KTISFSGCLTqlyffFSLGGtec 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
6TO7_B      111 LTLSFIALDRWYAICHPLLFKS--TARRALGSILGIWAVS-LAIMVP 154
Cdd:cd13954  89 FLLAVMAYDRYVAICHPLHYPTimNKRVCILLAAGSWLIGfLNSLIH 135
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
42-151 2.21e-05

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 45.31  E-value: 2.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       42 LVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDI-TESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDR 120
Cdd:cd14981  22 LIVLARSSKSHKWSVFYRLVAGLAITDLLGILLTSPVVLAVYAsNFEWDGGQPLCDYFGFMMSFFGLSSLLIVCAMAVER 101
                        90       100       110
                ....*....|....*....|....*....|...
6TO7_B      121 WYAICHPLLFKS--TARRALGSILGIWAVSLAI 151
Cdd:cd14981 102 FLAITHPFFYNShvKKRRARLMLGAVWAFALLI 134
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
39-146 2.63e-05

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 44.95  E-value: 2.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15231  17 GNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTECLLLAVMAY 96
                        90       100       110
                ....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRALGSIL--GIWA 146
Cdd:cd15231  97 DRYVAICNPLHYAVIMSRKVCLQLaaASWL 126
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
39-133 2.78e-05

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 45.05  E-value: 2.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15406  26 GNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCVFAIAECYMLTAMAY 105
                        90
                ....*....|....*
6TO7_B      119 DRWYAICHPLLFKST 133
Cdd:cd15406 106 DRYVAICNPLLYNVT 120
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
39-128 2.80e-05

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 44.78  E-value: 2.80e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLP---ASLL-VDITESwlFGHalCKVIPYLQAVSVSVAVLTLS 114
Cdd:cd15911  17 GNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPrmlASLLtGDRTIS--VSG--CIVQFYFFGSLAATECYLLA 92
                        90
                ....*....|....
6TO7_B      115 FIALDRWYAICHPL 128
Cdd:cd15911  93 VMSYDRYLAICKPL 106
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
39-130 4.21e-05

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 44.32  E-value: 4.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15409  17 GNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTECFLLAAMAY 96
                        90
                ....*....|..
6TO7_B      119 DRWYAICHPLLF 130
Cdd:cd15409  97 DRYVAICNPLLY 108
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
38-128 4.45e-05

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 44.52  E-value: 4.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       38 VGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15431  16 LGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGITECLLLAVMA 95
                        90
                ....*....|.
6TO7_B      118 LDRWYAICHPL 128
Cdd:cd15431  96 YDRFVAICNPL 106
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
39-179 5.36e-05

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 44.33  E-value: 5.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15950  17 GNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVESGVLLAMAF 96
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVMECssvLPELAARTRAFSVCD 179
Cdd:cd15950  97 DRYVAICHPLRYSAilTSQVIAQIGLAIVLRALLFMTPLTCLVTS---LPYCGSRVVPHSYCE 156
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
39-143 5.82e-05

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 44.00  E-value: 5.82e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15418  18 GNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSECFLLAAMAY 97
                        90       100
                ....*....|....*....|....*
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILG 143
Cdd:cd15418  98 DRYVAICNPLLYSSAMSKKLCMGLV 122
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
45-310 7.72e-05

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 43.59  E-value: 7.72e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       45 LAVWRNHHMRTV---TNYFLVNLSLADvLATAICLPASLLVDITE-SWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDR 120
Cdd:cd14987  20 VVVWVNLQAKRTgyeTHLYILNLAIAD-LCVVATLPVWVVSLVQHnQWPMGEFTCKITHLIFSINLFGSIFFLTCMSVDR 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      121 WYAIchpLLFKSTARRALGSI-----LGIWAVSLAIMVPQAAVMECSSVLPELAARTRAFSVCDERWADDLAPKIyhsCF 195
Cdd:cd14987  99 YLSV---TLFGNTSSRRKKIVrriicVLVWLLAFVASLPDTYFLKTVTSPSNNETYCRSFYPEESFKEWLIGMEL---VS 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      196 FIVTYLAPLGLMAMAYFqifrkLWGRQIPGTTSAEvkqmraRRKTAKMLMVVVLVFALCYLPISVLnVLKRVFGMFR--- 272
Cdd:cd14987 173 IVLGFVIPFPIIAVFYF-----LLARAISASSDQE------RKSSRKIIFSYVVVFLVCWLPYHTV-VLLDILSFLHlip 240
                       250       260       270
                ....*....|....*....|....*....|....*....
6TO7_B      273 -QASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd14987 241 fSCQLENFLYAALHVTQCFSLVHCCVNPILYSFINRNYR 279
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
39-161 8.26e-05

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 43.57  E-value: 8.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15424  17 GNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGSTECLLLGAMAY 96
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
6TO7_B      119 DRWYAICHPLLFKSTA--RRALGSILGIWAVSLAIMVPQAAVMEC 161
Cdd:cd15424  97 DRYLAICHPLLYAAAMgrWRQLQLALSCWAIGFLLSVINVGCTLR 141
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
39-128 9.40e-05

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 43.21  E-value: 9.40e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALC--KVIPYLQAVSVSVAVLTLsfI 116
Cdd:cd15227  17 GNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCvaQVFLFIFFAASELALLTV--M 94
                        90
                ....*....|..
6TO7_B      117 ALDRWYAICHPL 128
Cdd:cd15227  95 AYDRYVAICHPL 106
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
39-130 9.98e-05

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 43.17  E-value: 9.98e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15415  17 GNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEGFLLAVMAY 96
                        90
                ....*....|..
6TO7_B      119 DRWYAICHPLLF 130
Cdd:cd15415  97 DRYVAICNPLLY 108
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
39-152 1.24e-04

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 43.03  E-value: 1.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15410  30 GNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKAISYSGCMLQFFFFCTFVVTESFLLAVMAY 109
                        90       100       110
                ....*....|....*....|....*....|....
6TO7_B      119 DRWYAICHPLLFKSTARRALGSILGIWAVSLAIM 152
Cdd:cd15410 110 DRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIV 143
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
39-142 1.33e-04

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 42.94  E-value: 1.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15938  17 GNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAEMFLLTVMAY 96
                        90       100
                ....*....|....*....|....
6TO7_B      119 DRWYAICHPLLFKSTARRALGSIL 142
Cdd:cd15938  97 DRYVAICKPLHYTTIMSRRLCWVL 120
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
41-309 1.36e-04

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 42.85  E-value: 1.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       41 TLVCLAVWRNHHMRTVTNY--FLVNLSLADVLATaICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 117
Cdd:cd15969  16 LLNGLAVWIFFHIRNKTSFifYLKNIVIADLLMT-LTFPFKIIQDSGLGpWNFNFFLCRYTSVLFYASMYTSIVFLGLIS 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      118 LDRWYAICHPL----LFKSTARRALGsiLGIWAVSLAIMVPQAAVMECSSVLPELAARTRAFSVCDERWadDLAPKIYHS 193
Cdd:cd15969  95 LDRYLKVVKPFgdsrMYSITFTKVLS--ACVWLIMAFLSLPNIILTNGQPTEDNIHDCSKLKSPLGVKW--HTAVSYINI 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 CFFIVTYLaplgLMAMAYFQIFRKLWGRQIPGTTSAEVKqmrarRKTAKMLMVVVLVFALCYLPISvlnvLKRVFGMFRQ 273
Cdd:cd15969 171 CIFVAVLV----ILIVCYISISRYIYKSSKQFISSSSRT-----RKHNQSIRVVVAVFFVCFLPYH----LCRIPFTFSQ 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
6TO7_B      274 ------ASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKF 309
Cdd:cd15969 238 ldkildCTIKTILYYCKEATLFLSACNVCLDPIIYFFMCRSF 279
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
60-310 1.41e-04

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 42.79  E-value: 1.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       60 FLVNLSLADvLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARR--A 137
Cdd:cd15152  38 FMINLAIAD-LLQVLSLPLRIFYYLNKSWPFGKFLCMFCFYLKYVNMYASIYFLVCISVRRCLYLIYPFRYNDCKRKcdV 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      138 LGSILGIWAVslaimvpqaavmeCSSVLP-------ELAARTRAFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMA 210
Cdd:cd15152 117 YISIAGWLVV-------------CVGCLPfpllrqsQDTNPTCCFADLPLRNVGLTTSVIMLTIAELTGFVTPLLIVLYC 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      211 YFQIFRKLWGRQIPGTTSAEvkqmraRRKTAKMLMVVVLVFALCYLPISV---LNVLKRVfGMFRQASDREAVYAAFTFS 287
Cdd:cd15152 184 SWKTVMSLREKTPVLQDLGE------KKKALKMILTCAVVFLICFAPYHIsfpLDFLVKS-NKIKSCTARKVILIFHPVA 256
                       250       260
                ....*....|....*....|...
6TO7_B      288 HWLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15152 257 LCLASLNSCLDPVIYYFTTDEFK 279
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
39-128 1.68e-04

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 42.43  E-value: 1.68e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15940  17 GNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEIFLLTIMAY 96
                        90
                ....*....|
6TO7_B      119 DRWYAICHPL 128
Cdd:cd15940  97 DRYVAICNPL 106
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
40-130 1.81e-04

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 42.65  E-value: 1.81e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 119
Cdd:cd15224  18 NLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTECVLLAVMAYD 97
                        90
                ....*....|.
6TO7_B      120 RWYAICHPLLF 130
Cdd:cd15224  98 RYVAICHPLRY 108
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
40-313 2.13e-04

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 42.18  E-value: 2.13e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWL------FGHALCKVIPYLQAVSVSVAVLTL 113
Cdd:cd15352  18 NILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYlvisdqFIQHMDNVFDSMICISLVASICNL 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      114 SFIALDRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVMECSSVLpelaartrafsVCderwaddlapkiy 191
Cdd:cd15352  98 LAIAVDRYVTIFYALRYHSimTVRKALVLIAVIWVVCIVCGIVFIVYSESKTVI-----------VC------------- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      192 hscfFIVTYLAPLGLMAMAYFQIF--RKLWGRQIPGTTSAE--VKQMRARRKTAKMLMVVVLVFALCYLPIsvlnVLKRV 267
Cdd:cd15352 154 ----LITMFFAMLVLMATLYVHMFlfARLHVKRIAALPPAVdgAPQQRSCMKGAVTITILLGVFIVCWAPF----FLHLI 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
6TO7_B      268 FGMFRQASDREAVYAA-FTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15352 226 LIISCPHNPYCLCYTShFNTYLVLIMCNSVIDPLIYAFRSLEMRKTF 272
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
39-155 2.18e-04

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 42.11  E-value: 2.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15230  17 GNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTECFLLAAMAY 96
                        90       100       110
                ....*....|....*....|....*....|....*....
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQ 155
Cdd:cd15230  97 DRYVAICNPLLYTVimSKRVCIQLVAGSYLCGFVNSIVH 135
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
39-149 2.45e-04

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 42.20  E-value: 2.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15229  17 GNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFLLSAMAY 96
                        90       100       110
                ....*....|....*....|....*....|...
6TO7_B      119 DRWYAICHPLLFKSTARRALGSIL--GIWAVSL 149
Cdd:cd15229  97 DRYAAICHPLHYVQIMSKQVCVQLvgGAWALGF 129
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
39-313 2.98e-04

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 41.77  E-value: 2.98e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHAL-------CKVIPYLQAVSVSVAVL 111
Cdd:cd15359  17 GNLIVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKSQYYNHAIdwqtgsgCSTAGFFTVFASELSVY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      112 TLSFIALDRWYAICHPLLF--KSTARRALGSILGIWAVSLAI-MVPQAAVMECSSVlpelaartrafSVCDERWADDLAP 188
Cdd:cd15359  97 TLTVITLERWHTITYAMQLdrKLRLRHAILIMLGGWVFSLLIaVLPLVGVSNYMKV-----------SICLPMDIETLLS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      189 KIYHSCFFIVTYLAPLgLMAMAYFQIFRKLwgrQIPGTTSAEvkqmrARRKTAKMLMVVVLVFALCYLPISVLNVLKRVF 268
Cdd:cd15359 166 QAYILLILVLNVIAFL-VICACYIKIYLAV---QNPELVAKN-----KDTKIAKRMAILIFTDFTCMAPISFFAISAAFK 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
6TO7_B      269 GMFRQASDREAVYAAFtfshwlVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15359 237 VPLITVTNSKILLVLF------YPINSCANPFLYAIFTKAFRRDF 275
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
40-310 4.30e-04

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 41.31  E-value: 4.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATA-----ICLPASLLVDIT-ESWLFGHALCkvipylqAVSVSVAVLTL 113
Cdd:cd15349  18 NLLVLLAILRRVRLRRWVYICLANIALSDLLTGTsylvnICLSGERTFRLTpALWFLREGLL-------FTALAASTFSL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      114 SFIALDRWYAICHPLLFKSTAR--RALGSILGIWAVSLAI-MVPQ------AAVMECSSVLPELAARTRAFSVCderwad 184
Cdd:cd15349  91 LVTAVERYATMVRPVAENTATKtyRVYGMIVLCWILAFLIgFLPLlgwnclCDFRSCSSLLPLYSKSYILFCLV------ 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      185 dlapkiyhsCFFIVTylapLGLMAmAYFQIFRKLwgrQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLnVL 264
Cdd:cd15349 165 ---------IFFIIL----LTIIG-LYFAIYCLV---RASGQRVISARSRRRSLRLLKTVLMILGAFMVCWGPLFIL-LL 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
6TO7_B      265 KRVFGMFRQASDREAVYAAFTfshwLVYANSAANPIIYNFLSGKFR 310
Cdd:cd15349 227 VDFFCSSRSCKPLFGMEWVLA----LAVLNSAINPLIYSFRSLEVR 268
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
44-158 5.02e-04

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 41.28  E-value: 5.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       44 CLAVW---RNHHMRTVTNYFLVNLSLADVLATaICLPASLLVDI-TESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 119
Cdd:cd15167  19 CFALWafiQKRSSRKCINIYLINLLTADFLLT-LALPVKIAVDLgIAPWKLKIFHCQVTACLIYINMYLSIIFLGFVSID 97
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
6TO7_B      120 RWYAICHPLLFKSTARRALGSILG--IWAVSLAIMVPQAAV 158
Cdd:cd15167  98 RYLQLTHSSKLYRIQEPGFAKMISavVWTLVLFIMVPNMAI 138
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
40-313 5.91e-04

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 41.02  E-value: 5.91e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLAtAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 119
Cdd:cd15346  18 NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLA-GVAYTANLLLSGATTYKLTPTQWFLREGSMFVALSASVFSLLAIAIE 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      120 RWYAICHPLLFK-STARRALGSILGIWAVS-----LAIMVPQ--AAVMECSSVLPelaartrafsvcderwaddlapkIY 191
Cdd:cd15346  97 RYITMLKMKLHNgSNSFRSFLLISACWVISlilggLPIMGWNciSALSSCSTVLP-----------------------LY 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      192 HSCF-------FIVTYLAPLGLMAMAYFQI----FRKLWGRQIPGTTSAEVKQMrarrKTAKMLMVVVLVFALCYLPISV 260
Cdd:cd15346 154 HKHYilfcttvFTLLLLSIVILYCRIYSLVrtrsRRLTFRKNIRKASRSSEKSM----ALLKTVIIVLSVFIACWAPLFI 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
6TO7_B      261 LNVLKrvFGMFRQASDreavyAAFTFSHWLVYA--NSAANPIIYNFLSGKFREQF 313
Cdd:cd15346 230 LLLLD--VGCKVKTCS-----ILFKAEYFLVLAvlNSATNPIIYTLTNKEMRRAF 277
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
39-128 6.79e-04

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 40.82  E-value: 6.79e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15430  17 GNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTECVLLAVMAY 96
                        90
                ....*....|
6TO7_B      119 DRWYAICHPL 128
Cdd:cd15430  97 DRYVAICNPL 106
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
39-150 6.84e-04

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 40.91  E-value: 6.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPaSLLVDIteswlfgHALCKVIPYLQAVS--------VSVAV 110
Cdd:cd15236  17 GNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVP-KMLMNM-------QTQDQSIPYAGCISqmyffiffGCLDS 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
6TO7_B      111 LTLSFIALDRWYAICHPLLFKSTARRALGSIL--GIWAVSLA 150
Cdd:cd15236  89 FLLAVMAYDRYVAICHPLHYTAIMRPELCVLLvaGSWVLTCF 130
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
40-313 7.90e-04

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 40.60  E-value: 7.90e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESwLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 119
Cdd:cd15211  17 NVLVIYLVVSFKKLQTTSNAFIVNGCVADLLVCAFWMPQEAVLGSTGT-LLVLGYRLFREGLLFLGLTVSLLSHSLIALN 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      120 RWYAICH-PLLFKS--TARRALGSILGIWAVSLAIMVPqaavmecssvLPELAARTRAFSVCDERWADDLAPKI---YHS 193
Cdd:cd15211  96 RYVLITKlPAVYQAlyQKRNTEWMIALSWALALGLLLP----------WLTSFRYPTKSCHDSADGSFAVVSVLssrYPA 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      194 CFFIVTYLAPLGLMAMAYFQIFRKLWGR-------QIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPIsvlnVLKR 266
Cdd:cd15211 166 LLLAFTVLGQTALVLHCYFGIFRRVQISvkrvsvlNFQIVNNLPYSRPRKDKRLGLYVLLVCCVFLLTTEPL----VWVS 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
6TO7_B      267 VFGMFRQASdreavyAAFTFSHWLVY-ANSAANPIIYNFLSGKFREQF 313
Cdd:cd15211 242 LAGLFVPVP------VALQTASWLLFcTLFVLNPFLYTWKNEEFRRSF 283
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
39-130 1.04e-03

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 40.11  E-value: 1.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPaSLLVDITeswlfghALCKVIPY----LQ----AVSVSVAV 110
Cdd:cd15945  30 GNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGP-KMLVDLL-------AKRKSIPFygcaLQmfffAAFADAEC 101
                        90       100
                ....*....|....*....|
6TO7_B      111 LTLSFIALDRWYAICHPLLF 130
Cdd:cd15945 102 LLLAVMAYDRYVAICNPLLY 121
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
39-138 1.06e-03

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 40.37  E-value: 1.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15419  17 GNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEGFLLAAMAY 96
                        90       100
                ....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRAL 138
Cdd:cd15419  97 DRFIAICNPLLYPVIMSRRV 116
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
40-313 1.11e-03

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 40.01  E-value: 1.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATaiclpASLLVDITESWLFGHALCKVIPY-LQAVSVSVAVLTLSFIAL 118
Cdd:cd15961  18 NAIVVLIIFQNPSLRAPMFLLIGSLALADLLAG-----IGLILNFIFAYLLQSEAAKLVTVgLIVASFSASVCSLLAITV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKS--TARRALGSILGIWAVSLaimvpqaavmeCSSVLPELAARTRAfsvcDERWADDLAPKIYHSCFF 196
Cdd:cd15961  93 DRYLSLYYALTYNSerTVTFTYVMLVLLWGASI-----------CLGLLPVMGWNCLA----DESTCSVVRPLTKNNAAI 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      197 I-VTYLAPLGLMAMAYFQIFRKLW--GRQIPGTTS-AEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLkrvfgmfr 272
Cdd:cd15961 158 LsVSFLLMFALMLQLYIQICKIVMrhAHQIALQHHfLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLI-------- 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
6TO7_B      273 qasdreavyAAFTFSHWLVYA-------NSAANPIIYNFLSGKFREQF 313
Cdd:cd15961 230 ---------ADYTYPSIYTYAtllpatyNSIINPVIYAFRNQEIQKAL 268
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
39-131 1.37e-03

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 40.00  E-value: 1.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15408  30 GNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKVISFTGCLTQLYFYAVFATTECYLLAAMAY 109
                        90
                ....*....|...
6TO7_B      119 DRWYAICHPLLFK 131
Cdd:cd15408 110 DRYVAICNPLLYT 122
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
39-130 1.48e-03

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 39.65  E-value: 1.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15943  31 GNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKTISFTGCAAQMYFFVAFATTECFLLAVMAY 110
                        90
                ....*....|..
6TO7_B      119 DRWYAICHPLLF 130
Cdd:cd15943 111 DRYVAICNPLLY 122
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
39-138 1.61e-03

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 39.77  E-value: 1.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 118
Cdd:cd15946  17 GNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITECTLFSVMAY 96
                        90       100
                ....*....|....*....|
6TO7_B      119 DRWYAICHPLLFKSTARRAL 138
Cdd:cd15946  97 DRYVAICHPLRYKVIMSWGL 116
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
39-128 1.72e-03

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 39.57  E-value: 1.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASL--LVDITESWLFGHALCKVIPYLqAVSVSVAVLtLSFI 116
Cdd:cd15237  17 GNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLvhLLSEHKTISFVGCAAQMFFFL-ALGVTECVL-LAVM 94
                        90
                ....*....|..
6TO7_B      117 ALDRWYAICHPL 128
Cdd:cd15237  95 AYDRYVAICNPL 106
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
39-159 2.14e-03

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 39.11  E-value: 2.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWL--FGHALCKvIPYLQAVSVSVAVLtLSFI 116
Cdd:cd15226  17 GNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTisFGGCMAQ-IFFLHFFGGSEMVL-LIAM 94
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
6TO7_B      117 ALDRWYAICHPLLFKS--TARRALGSILGIWAVSLAIMVPQAAVM 159
Cdd:cd15226  95 AFDRYVAICKPLHYLTimSPRMCILLVVASWIIGFIHSLSQLAFV 139
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
40-313 3.25e-03

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 38.76  E-value: 3.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLAT--------AICLPASLLVDITESwlFGHALCKVIPYLQAVSVSVAVL 111
Cdd:cd15354  18 NILVILAIVKNKNLHSPMYFFVCSLAVADMLVSvsnawetiTIYLLNNRHLVIEDA--FVRHIDNVFDSLICISVVASMC 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      112 TLSFIALDRWYAICHPLLFKS--TARRALGSILGIWAVSLAimvpqaavmecSSVLPELAARTRAFSVCderwaddlapk 189
Cdd:cd15354  96 SLLAIAVDRYVTIFYALRYHNimTVRRAGIIIACIWTFCTG-----------CGIIFILYSESTYVIIC----------- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      190 iyhscfFIVTYLAPLGLMAMAYFQIFrkLWGRQ-------IPGTTSAevkQMRARRKTAKMLMVVVLVFALCYLPISVLN 262
Cdd:cd15354 154 ------LITMFFAMLFLMVSLYIHMF--LLARThvkriaaLPGYNSV---RQRTSMKGAVTLTILLGIFIVCWAPFFLHL 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
6TO7_B      263 VLkrvfgmfrQASDREAVYAAFTFSHW-----LVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15354 223 IL--------MISCPQNLYCVCFMSHFnmyliLIMCNSVIDPLIYAFRSQEMRKTF 270
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
39-147 3.54e-03

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 38.68  E-value: 3.54e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNY-FLVNLSLADVLATAICLPASLLVDITESW-LFGHALCKVIPYLQAVSVSVAVLTLSFI 116
Cdd:cd15941  17 GNLLILLTIGSDPHLHGLPMYhFLGHLSFLDACLSSVTVPKVLAGLLTLSGrTISFEGCVVQLYAFHFLASTECFLYTVM 96
                        90       100       110
                ....*....|....*....|....*....|...
6TO7_B      117 ALDRWYAICHPLLFKSTARR--ALGSILGIWAV 147
Cdd:cd15941  97 AYDRYLAICHPLHYPTAMNRrmCAGLAGGTWAT 129
7tmA_MrgprA cd15105
mas-related G protein-coupled receptor subtype A, member of the class A family of ...
244-314 5.09e-03

mas-related G protein-coupled receptor subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320233  Cd Length: 276  Bit Score: 38.19  E-value: 5.09e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
6TO7_B      244 LMVVVLVFALCYLPISV----LNVLKRVFGMFRqasdreavYAAFTFSHWLVYANSAANPIIYnFLSGKFREQFK 314
Cdd:cd15105 195 IMLTVLVFLLCGLPFGIywflLFWIKDDFHVLD--------YGLYLASVVLTAVNSCANPIIY-FFVGSFRHRLK 260
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
39-313 5.28e-03

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 37.92  E-value: 5.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADvLATAICLPASLLVDI-TESWLFGHAL-------CKVIPYLQAVSVSVAV 110
Cdd:cd15360  17 GNIVVLAILLTSQYKLTVPRFLMCNLAFAD-LCMGIYLLLIASVDIrTKSQYYNYAIdwqtgagCAAAGFFTVFASELSV 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      111 LTLSFIALDRWYAICHPLLF--KSTARRALGSILGIWAVSLAI-MVPQAAVMECSSVlpelaartrafSVCDERWADDLA 187
Cdd:cd15360  96 YTLTVITLERWHTITYAMQLdrKVRLRHAAVIMVGGWIFAFTVaLLPIFGISSYMKV-----------SICLPMDIESPL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      188 PKIYHSCFFIVTYLAPLgLMAMAYFQIFRKLWGRQIPGTTSAEvkqmrarrKTAKMLMVVVLVFALCYLPISVLNVLKRV 267
Cdd:cd15360 165 SQAYIIFILVLNVLAFL-IICACYIKIYLTVRNPNFVSSNSDT--------KIAKRMAVLIFTDFLCMAPISFFAISASL 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
6TO7_B      268 FGMFRQASDREAVYAAFtfshwlVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15360 236 KVPLITVSKSKILLVLF------YPINSCANPFLYAIFTKTFRRDF 275
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
40-313 5.58e-03

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 37.88  E-value: 5.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATaiclpASLLVDITESWLFGHALCKVIPYLQA----VSVSVAVLTLSF 115
Cdd:cd15345  18 NLMVLIAIWKNNRFHNRMYFFIGNLALCDLLAG-----IAYKVNILMSGKKTFSLSPTQWFLREgsmfVALGASTFSLLA 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      116 IALDRWYAICHPLLFKSTARRALGSILGI-WAVSLAI-MVPQAA------VMECSSVLPELAARTRAFSvcderwaddla 187
Cdd:cd15345  93 IAIERHLTMIKMRPYDANKRYRVFLLIGTcWLISVLLgALPILGwncldnLPDCSTILPLYSKKYVAFC----------- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      188 pkiyhscffIVTYLAPLGLMAMAYFQIFrklwgrQIPGTTSAEVKQMRARRKTAKMLMVVVL---VFALCYLPISVLNVL 264
Cdd:cd15345 162 ---------ISIFIAILVAIVILYARIY------ILVKSSSRRVTNHRNSERSMALLRTVVIvvgVFIACWSPLFILLLI 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
6TO7_B      265 KrvfgmfrQASDREAVYAAFTFSHWLVYA--NSAANPIIYNFLSGKFREQF 313
Cdd:cd15345 227 D-------VACEVKQCPILYKADWFIALAvlNSAMNPIIYTLASKEMRRAF 270
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
40-313 6.50e-03

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 37.86  E-value: 6.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICL-------PASLLVDItESWLFGHALCKvipylqaVSVSVAVLT 112
Cdd:cd15342  18 NLLVIAAIFINRRFHYPIYYLLGNLAAADLFAGVAYLflmfhtgPWTAKLSL-YQWFLRQGLLD-------TSLTASVAN 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      113 LSFIALDRWYAICHPLLF-KSTARRALGSILGIWAVSLAIMVPQAAVMECssvlpelaartrafsVCDERWADDLAPKIY 191
Cdd:cd15342  90 LLAIAVERHQTIFTMQLHsKMSNQRVVILIFGIWMVALILGLIPAMGWNC---------------LCDLKRCSTMAPLYS 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      192 HS--CFFIVTYLAPLGLMAMAYFQIF---RKLWGRQIPGTTSaevkQMRARRKTAKMLMVVVLV---FALCYLPISVLNV 263
Cdd:cd15342 155 RSylVFWALSNLLTFLIMVAVYTRIFiyvRRKSQRMSEHHSS----HPRYRETVLGLMKTVVIIlgaFVVCWTPGQVVLL 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
6TO7_B      264 LKrvfGMFRQASDREAVYAAFTFshwLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15342 231 LD---GLGCESCNVLAYEKYFLL---LAEINSLVNPIVYSYRDKEMRKTF 274
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
39-130 6.66e-03

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 37.62  E-value: 6.66e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLPaSLLVD-ITESwlfghalcKVIPYL----QAVSVSVAVLT- 112
Cdd:cd15417  17 WNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITP-KMLSDfFREQ--------KTISFVgcatQYFVFSGMGLTe 87
                        90       100
                ....*....|....*....|.
6TO7_B      113 ---LSFIALDRWYAICHPLLF 130
Cdd:cd15417  88 cflLAAMAYDRYVAICNPLLY 108
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
39-128 7.08e-03

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 37.43  E-value: 7.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLATAICLP---ASLLV-DITESWL-----------FGHALCkvipYLQA 103
Cdd:cd15225  17 GNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPkmlVNLLSeDKTISFLgcatqmffflfLGGTEC----FLLA 92
                        90       100
                ....*....|....*....|....*
6TO7_B      104 VsvsvavltlsfIALDRWYAICHPL 128
Cdd:cd15225  93 A-----------MAYDRYVAICNPL 106
7tmA_RXFP2_LGR8 cd15966
relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G ...
95-312 7.19e-03

relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural similarity, but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. INSL3 is the endogenous ligand for RXFP2, which couples to the G(s) protein to increase intracellular cAMP levels, but also to the GoB protein to decrease cAMP formation. RXFP2 (or LGR8) is expressed in various tissues including the brain, kidney, muscle, testis, thyroid, uterus, and peripheral blood cells, among others.


Pssm-ID: 320632  Cd Length: 287  Bit Score: 37.84  E-value: 7.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       95 CKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLL-FKSTARRALGSILGIWAVSLAImvpqaavmecsSVLPELAARTR 173
Cdd:cd15966  80 CRIIGFLAMLSTEVSVLLLTYLTLEKYLVIVFPFSnIRPGKCQTLIILISIWLVGFII-----------AVIPFWNEDFF 148
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      174 AF-----SVCDERWAD---DLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLwgrQIPGTTSAEVK-QMRARRKTAKML 244
Cdd:cd15966 149 GNyygknGVCFPLHSDqteKIGAKGYSTGIFLGLNLLAFIIIVFSYSSMFCSI---QKTGLQTTEVRsHIHRDVAVANRF 225
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
6TO7_B      245 MVVVLVFALCYLPISVLNVLKrvfgMFRqasdreaVYAAFTFSHWLVY----ANSAANPIIYNFLSGKFREQ 312
Cdd:cd15966 226 FFIVFSDAICWIPIFLLKILS----LFQ-------VEIPGTITSWIVIfilpINSALNPILYTLTTSFFKEK 286
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
40-313 9.38e-03

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 37.20  E-value: 9.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       40 NTLVCLAVWRNHHMRTVTNY-FLVNLSLADVLATAICLPASLLVDI----TESWLFGHALCKVIpylqaVSVSVAVLTLS 114
Cdd:cd15340  18 NLLVLCVILHSRSLRCRPSYhFIGSLAVADLLGSVIFVYSFLDFHVfhrkDSPNVFLFKLGGVT-----ASFTASVGSLF 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      115 FIALDRWYAICHPLLFKS--TARRALGSILGIWAVSLAImvpqaavmecsSVLPELAAR-TRAFSVCDerwadDLAPKIY 191
Cdd:cd15340  93 LTAIDRYISIHRPLAYKRivTRTKAVIAFCVMWTIAIVI-----------AVLPLLGWNcKKLNSVCS-----DIFPLID 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B      192 HS--CFFIVTYLAPLGLMAMAYFQIFRKLWG-----------RQIPGTTSAEVK-------QMRARRKTAKMLMVVVLVF 251
Cdd:cd15340 157 ETylMFWIGVTSVLLLFIVYAYMYILWKAHHhavrmlqrgtqKSIIVYTSEDGKvqttrpdQTRMDIRLAKTLVLILVVL 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
6TO7_B      252 ALCYLPISVLnvlkRVFGMFRQASDreAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQF 313
Cdd:cd15340 237 IICWGPLLAI----MVYDVFGKMNK--LIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAF 292
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
39-159 9.70e-03

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 37.05  E-value: 9.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6TO7_B       39 GNTLVCLAVWRNHHMRTVTNY-FLVNLSLADVLATAICLPASL--LVDITESWLFGHALCKVIpYLQAVSVSvAVLTLSF 115
Cdd:cd15935  17 GNLLIVVTVHADPHLLQSPMYfFLANLSLIDMTLGSVAVPKVLadLLTCGRTISFGGCMAQLF-FLHFLGGS-EMLLLTL 94
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
6TO7_B      116 IALDRWYAICHPLLFKSTA--RRALGSILGIWAVSLAIMVPQAAVM 159
Cdd:cd15935  95 MAYDRYVAICHPLRYLAVMnrQLCIKLLAACWAGGFLHSATQAALV 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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