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Conserved domains on  [gi|2281652281|pdb|7ZRY|B]
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Chain B, REST corepressor 1

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 10446569)

SANT/Myb domain-containing protein binds DNA and may function as a transcription factor

CATH:  1.10.10.60
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  1631139|8882580

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 78-121 1.72e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 56.36  E-value: 1.72e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
7ZRY_B         78 RWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYR 121
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
 
Name Accession Description Interval E-value
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 78-121 1.72e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 56.36  E-value: 1.72e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
7ZRY_B         78 RWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYR 121
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 78-120 4.30e-08

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 47.18  E-value: 4.30e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
7ZRY_B       78 RWTTEEQLLAVQAIRKYG-RDFQAISDVIGNKSVVQVKNFFVNY 120
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNL 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
78-123 2.07e-07

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 45.68  E-value: 2.07e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
7ZRY_B          78 RWTTEEQLLAVQAIRKYG-RDFQAISDVIGNKSVVQVKNFFVNYRRR 123
Cdd:smart00717   3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
 
Name Accession Description Interval E-value
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 78-121 1.72e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 56.36  E-value: 1.72e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
7ZRY_B         78 RWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYR 121
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 78-120 4.30e-08

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 47.18  E-value: 4.30e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
7ZRY_B       78 RWTTEEQLLAVQAIRKYG-RDFQAISDVIGNKSVVQVKNFFVNY 120
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNL 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
78-123 2.07e-07

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 45.68  E-value: 2.07e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
7ZRY_B          78 RWTTEEQLLAVQAIRKYG-RDFQAISDVIGNKSVVQVKNFFVNYRRR 123
Cdd:smart00717   3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-bind_7 pfam15963
Myb DNA-binding like;
78-128 4.11e-03

Myb DNA-binding like;


Pssm-ID: 464956 [Multi-domain]  Cd Length: 85  Bit Score: 34.82  E-value: 4.11e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
7ZRY_B         78 RWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVN--------------YRRRFNIDE 128
Cdd:pfam15963  10 RWSKEETELFYKALSMFGTDFSLIAQLFPGRTRRQIKLKFKReerknpelvdkalkNRKPFDLEE 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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