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Conserved domains on  [gi|2706656519|sp|A0A0J9XBC9|]
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RecName: Full=AA9 family lytic polysaccharide monooxygenase D; Short=LPMO9D; AltName: Full=Cellulase LPMO9D; AltName: Full=Endo-beta-1,4-glucanase LPMO9D; Short=Endoglucanase LPMO9D; AltName: Full=Glycosyl hydrolase 61 family protein LPMO9D; Flags: Precursor

Protein Classification

lytic polysaccharide monooxygenase auxiliary activity family 9 protein( domain architecture ID 15340318)

lytic polysaccharide monooxygenase (LPMO) auxiliary activity family 9 (AA9) protein may be involved in the degradation of cellulose or lignocellulose, chitin, or other polysaccharides

CATH:  2.70.50.70
CAZY:  AA9
Gene Ontology:  GO:0016787|GO:0046872
PubMed:  24688660|25217478

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPMO_AA9 cd21175
lytic polysaccharide monooxygenase (LPMO) auxiliary activity family 9 (AA9); AA9 proteins are ...
 22-240 4.12e-91

lytic polysaccharide monooxygenase (LPMO) auxiliary activity family 9 (AA9); AA9 proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs) involved in the cleavage of cellulose chains with oxidation of carbons C1 and/or C4 and C6. Activities include lytic cellulose monooxygenase (C1-hydroxylating) (EC 1.14.99.54) and lytic cellulose monooxygenase (C4-dehydrogenating) (EC 1.14.99.56). The family used to be called GH61 because weak endoglucanase activity had been demonstrated in some family members.


:

Pssm-ID: 410622 [Multi-domain]  Cd Length: 216  Bit Score: 270.62  E-value: 4.12e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2706656519  22 HGIVTDIEIDGEWYtsslvfEDPYKIPIPERISWsffGSGNSPVADFTTRDIVCNGNAS-AAALVAEVDAGAEITFYWDT 100
Cdd:cd21175     1 HGTVTSLTVNGVDY------GGWDPDSYVRKPPN---ATDNGPVTDVTSPDIACNKGGTtPAPKTATVAAGSTVTFEWNT 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2706656519 101 WPE-SHKGPVMTYLANCGSDCRTVDPGALFYFKIDHAGLEDGE--WISDQIIANNLSYTITIPEDIAPGNYLIRHELLAL 177
Cdd:cd21175    72 WPDwSHKGPVLTYMAKCPGDCTDVDGTGLGWFKIDEEGLDSGGgaWATDKLIANGGTWTVTIPSNLAPGNYLLRHEIIAL 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2706656519 178 HLASDELGAQFYPMCANLRISGSG-IINPTGVQFPGAYKMDDPGILVNIYNDIDT-YTIPGPPPY 240
Cdd:cd21175   152 HSAGSVGGAQFYPSCAQIEVTGGGtGAPPPGVSFPGAYKATDPGILFNIYYPPPTsYTIPGPAVW 216
 
Name Accession Description Interval E-value
LPMO_AA9 cd21175
lytic polysaccharide monooxygenase (LPMO) auxiliary activity family 9 (AA9); AA9 proteins are ...
 22-240 4.12e-91

lytic polysaccharide monooxygenase (LPMO) auxiliary activity family 9 (AA9); AA9 proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs) involved in the cleavage of cellulose chains with oxidation of carbons C1 and/or C4 and C6. Activities include lytic cellulose monooxygenase (C1-hydroxylating) (EC 1.14.99.54) and lytic cellulose monooxygenase (C4-dehydrogenating) (EC 1.14.99.56). The family used to be called GH61 because weak endoglucanase activity had been demonstrated in some family members.


Pssm-ID: 410622 [Multi-domain]  Cd Length: 216  Bit Score: 270.62  E-value: 4.12e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2706656519  22 HGIVTDIEIDGEWYtsslvfEDPYKIPIPERISWsffGSGNSPVADFTTRDIVCNGNAS-AAALVAEVDAGAEITFYWDT 100
Cdd:cd21175     1 HGTVTSLTVNGVDY------GGWDPDSYVRKPPN---ATDNGPVTDVTSPDIACNKGGTtPAPKTATVAAGSTVTFEWNT 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2706656519 101 WPE-SHKGPVMTYLANCGSDCRTVDPGALFYFKIDHAGLEDGE--WISDQIIANNLSYTITIPEDIAPGNYLIRHELLAL 177
Cdd:cd21175    72 WPDwSHKGPVLTYMAKCPGDCTDVDGTGLGWFKIDEEGLDSGGgaWATDKLIANGGTWTVTIPSNLAPGNYLLRHEIIAL 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2706656519 178 HLASDELGAQFYPMCANLRISGSG-IINPTGVQFPGAYKMDDPGILVNIYNDIDT-YTIPGPPPY 240
Cdd:cd21175   152 HSAGSVGGAQFYPSCAQIEVTGGGtGAPPPGVSFPGAYKATDPGILFNIYYPPPTsYTIPGPAVW 216
AA9 pfam03443
Auxiliary Activity family 9 (formerly GH61); Although weak endoglucanase activity has been ...
 23-232 3.12e-88

Auxiliary Activity family 9 (formerly GH61); Although weak endoglucanase activity has been demonstrated in several members of this family, they lack the clustered conserved catalytic acidic amino acids present in most glycoside hydrolases. Many members of this family lack measurable cellulase activity on their own, but enhance the activity of other cellulolytic enzymes. They are therefore unlikely to be true glycoside hydrolases. The substrate-binding surface of this family is a flat Ig-like fold. This family of enzymes were originally classified as glycoside hydrolases (GH61) and they have been reclassified as the Auxiliary Activity Family 9 (AA9) of CAZy.


Pssm-ID: 460918  Cd Length: 208  Bit Score: 262.90  E-value: 3.12e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2706656519  23 GIVTDIEIDGEWYTSSLVFEDPykipiPERISWSFfgSGNSPVADFTTRDIVCNgNASAAALVAEVDAGAEITFYWD-TW 101
Cdd:pfam03443   1 GTVTSLVVNGVTYGGYDPVSDP-----VIRWTRPN--TDNGPVTDVTSPDIRCN-GAGPAATAAPVAAGSTVTFQWTqGW 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2706656519 102 PESHKGPVMTYLANC-GSDCRTVDPGALFYFKIDHAGLEDG--EWISDQIIANNLSYTITIPEDIAPGNYLIRHELLALH 178
Cdd:pfam03443  73 PESHKGPVITYLAKCpGGDCATVDGTGLVWFKIDEAGLDSGgsTWATDKLIANNGTWTVTIPSDLAPGNYLLRHEIIALH 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2706656519 179 LASDELGAQFYPMCANLRISGSGIINPT-GVQFPGAYKMDDPGILVNIYNDIDTY 232
Cdd:pfam03443 153 SAGSVGGAQFYPQCAQLEVTGSGSGTPGpGVSFPGAYKATDPGILFNIYSPGPTS 207
 
Name Accession Description Interval E-value
LPMO_AA9 cd21175
lytic polysaccharide monooxygenase (LPMO) auxiliary activity family 9 (AA9); AA9 proteins are ...
 22-240 4.12e-91

lytic polysaccharide monooxygenase (LPMO) auxiliary activity family 9 (AA9); AA9 proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs) involved in the cleavage of cellulose chains with oxidation of carbons C1 and/or C4 and C6. Activities include lytic cellulose monooxygenase (C1-hydroxylating) (EC 1.14.99.54) and lytic cellulose monooxygenase (C4-dehydrogenating) (EC 1.14.99.56). The family used to be called GH61 because weak endoglucanase activity had been demonstrated in some family members.


Pssm-ID: 410622 [Multi-domain]  Cd Length: 216  Bit Score: 270.62  E-value: 4.12e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2706656519  22 HGIVTDIEIDGEWYtsslvfEDPYKIPIPERISWsffGSGNSPVADFTTRDIVCNGNAS-AAALVAEVDAGAEITFYWDT 100
Cdd:cd21175     1 HGTVTSLTVNGVDY------GGWDPDSYVRKPPN---ATDNGPVTDVTSPDIACNKGGTtPAPKTATVAAGSTVTFEWNT 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2706656519 101 WPE-SHKGPVMTYLANCGSDCRTVDPGALFYFKIDHAGLEDGE--WISDQIIANNLSYTITIPEDIAPGNYLIRHELLAL 177
Cdd:cd21175    72 WPDwSHKGPVLTYMAKCPGDCTDVDGTGLGWFKIDEEGLDSGGgaWATDKLIANGGTWTVTIPSNLAPGNYLLRHEIIAL 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2706656519 178 HLASDELGAQFYPMCANLRISGSG-IINPTGVQFPGAYKMDDPGILVNIYNDIDT-YTIPGPPPY 240
Cdd:cd21175   152 HSAGSVGGAQFYPSCAQIEVTGGGtGAPPPGVSFPGAYKATDPGILFNIYYPPPTsYTIPGPAVW 216
AA9 pfam03443
Auxiliary Activity family 9 (formerly GH61); Although weak endoglucanase activity has been ...
 23-232 3.12e-88

Auxiliary Activity family 9 (formerly GH61); Although weak endoglucanase activity has been demonstrated in several members of this family, they lack the clustered conserved catalytic acidic amino acids present in most glycoside hydrolases. Many members of this family lack measurable cellulase activity on their own, but enhance the activity of other cellulolytic enzymes. They are therefore unlikely to be true glycoside hydrolases. The substrate-binding surface of this family is a flat Ig-like fold. This family of enzymes were originally classified as glycoside hydrolases (GH61) and they have been reclassified as the Auxiliary Activity Family 9 (AA9) of CAZy.


Pssm-ID: 460918  Cd Length: 208  Bit Score: 262.90  E-value: 3.12e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2706656519  23 GIVTDIEIDGEWYTSSLVFEDPykipiPERISWSFfgSGNSPVADFTTRDIVCNgNASAAALVAEVDAGAEITFYWD-TW 101
Cdd:pfam03443   1 GTVTSLVVNGVTYGGYDPVSDP-----VIRWTRPN--TDNGPVTDVTSPDIRCN-GAGPAATAAPVAAGSTVTFQWTqGW 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2706656519 102 PESHKGPVMTYLANC-GSDCRTVDPGALFYFKIDHAGLEDG--EWISDQIIANNLSYTITIPEDIAPGNYLIRHELLALH 178
Cdd:pfam03443  73 PESHKGPVITYLAKCpGGDCATVDGTGLVWFKIDEAGLDSGgsTWATDKLIANNGTWTVTIPSDLAPGNYLLRHEIIALH 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2706656519 179 LASDELGAQFYPMCANLRISGSGIINPT-GVQFPGAYKMDDPGILVNIYNDIDTY 232
Cdd:pfam03443 153 SAGSVGGAQFYPQCAQLEVTGSGSGTPGpGVSFPGAYKATDPGILFNIYSPGPTS 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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