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Conserved domains on  [gi|1086491|gb|AAB01688|]
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TWIK-1 [Homo sapiens]

Protein Classification

potassium channel family protein( domain architecture ID 10545436)

potassium channel family protein spans the cell membrane to form a conduction pathway or pore, through which selective ions such as potassium, sodium, and calcium, translocate across cell membranes

Gene Ontology:  GO:0005267|GO:0034220|GO:0005216|GO:0071805|GO:0016020
PubMed:  15816170|9525859|11836519|11178249|1772658
SCOP:  4000034
TCDB:  1.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 98-157 1.19e-15

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


:

Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 70.76  E-value: 1.19e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086491     98 GNWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRIT 157
Cdd:pfam07885  18 EGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLT 77
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 191-267 1.69e-08

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


:

Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 50.73  E-value: 1.69e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1086491    191 TVSCFFFIPAAVFSVLEDDW--NFLESFYFCFISLSTIGLGDYVPGegynqkfRELYKIGITCYLLLGLIAMLVVLETF 267
Cdd:pfam07885   1 IVLLLVLIFGTVYYLLEEGWewSFLDALYFSFVTLTTVGYGDIVPL-------TDAGRLFTIFYILIGIPLFAIFLAVL 72
 
Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 98-157 1.19e-15

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 70.76  E-value: 1.19e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086491     98 GNWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRIT 157
Cdd:pfam07885  18 EGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLT 77
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 191-267 1.69e-08

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 50.73  E-value: 1.69e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1086491    191 TVSCFFFIPAAVFSVLEDDW--NFLESFYFCFISLSTIGLGDYVPGegynqkfRELYKIGITCYLLLGLIAMLVVLETF 267
Cdd:pfam07885   1 IVLLLVLIFGTVYYLLEEGWewSFLDALYFSFVTLTTVGYGDIVPL-------TDAGRLFTIFYILIGIPLFAIFLAVL 72
TrkG COG0168
Trk-type K+ transport system, membrane component [Inorganic ion transport and metabolism];
104-229 6.60e-03

Trk-type K+ transport system, membrane component [Inorganic ion transport and metabolism];


Pssm-ID: 439938 [Multi-domain]  Cd Length: 414  Bit Score: 38.14  E-value: 6.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086491  104 FTSALFFASTVLSTTGYGhTVP---LSDGGKAFCIIYSVIG------------IPFTLLFLT--AVVQRITVHVTRRPVL 166
Cdd:COG0168 236 LRAALFQVVSILTTTGFA-TVDygqWPPFSLLLLILLMFIGgsagstaggikvTRFAVLLKAirRELRRLIHPNAVRPVR 314

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1086491  167 YFHIRwgFSKQVVAIVhavlLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLG 229
Cdd:COG0168 315 IGGRR--IPEEVIRKA----LAFFFLYLLLVVVGTLLLSLTEGLDFLTALFEVASAFGNVGLS 371
 
Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 98-157 1.19e-15

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 70.76  E-value: 1.19e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086491     98 GNWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRIT 157
Cdd:pfam07885  18 EGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLT 77
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 191-267 1.69e-08

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 50.73  E-value: 1.69e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1086491    191 TVSCFFFIPAAVFSVLEDDW--NFLESFYFCFISLSTIGLGDYVPGegynqkfRELYKIGITCYLLLGLIAMLVVLETF 267
Cdd:pfam07885   1 IVLLLVLIFGTVYYLLEEGWewSFLDALYFSFVTLTTVGYGDIVPL-------TDAGRLFTIFYILIGIPLFAIFLAVL 72
TrkG COG0168
Trk-type K+ transport system, membrane component [Inorganic ion transport and metabolism];
104-229 6.60e-03

Trk-type K+ transport system, membrane component [Inorganic ion transport and metabolism];


Pssm-ID: 439938 [Multi-domain]  Cd Length: 414  Bit Score: 38.14  E-value: 6.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086491  104 FTSALFFASTVLSTTGYGhTVP---LSDGGKAFCIIYSVIG------------IPFTLLFLT--AVVQRITVHVTRRPVL 166
Cdd:COG0168 236 LRAALFQVVSILTTTGFA-TVDygqWPPFSLLLLILLMFIGgsagstaggikvTRFAVLLKAirRELRRLIHPNAVRPVR 314

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1086491  167 YFHIRwgFSKQVVAIVhavlLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLG 229
Cdd:COG0168 315 IGGRR--IPEEVIRKA----LAFFFLYLLLVVVGTLLLSLTEGLDFLTALFEVASAFGNVGLS 371
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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