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Conserved domains on  [gi|233656|gb|AAB19482|]
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3-hydroxyacyl-CoA dehydrogenase, partial [Homo sapiens]

Protein Classification

fatty acid oxidation complex subunit alpha FadB( domain architecture ID 1003069)

fatty acid oxidation complex subunit alpha FadB is involved in the aerobic and anaerobic degradation of long-chain fatty acids via the beta-oxidation cycle and it catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA

CATH:  3.40.50.720|1.10.1040.50|3.90.226.10
EC:  5.3.3.8|5.1.2.3|1.1.1.35|4.2.1.17
Gene Ontology:  GO:0070403|GO:0003857|GO:0008692|GO:0004165|GO:0004300|GO:0006635|GO:0036125
SCOP:  4000107|4000036

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
fadB super family cl32726
fatty acid oxidation complex subunit alpha FadB;
4-204 2.55e-28

fatty acid oxidation complex subunit alpha FadB;


The actual alignment was detected with superfamily member PRK11730:

Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 111.88  E-value: 2.55e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 233656      4 VDQVLE-EFGFKMGPFRVSDLAGLDVGwksRKGQGLtgptLLPGTPARKRGNRRycPIPDVLCELGRFGQKTGKGWYQY- 81
Cdd:PRK11730 523 IDKVMEkQFGWPMGPAYLLDVVGIDTA---HHAQAV----MAEGFPDRMKKDYR--DAIDVLFEAKRFGQKNGKGFYRYe 593

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 233656     82 -DKPlGRIHK-PDPWLSTFLsryrKPHHIEPRTISQDEILERCLYSLINEAFRILGEGIAASPEHIDVVYLHGYGCARHK 159
Cdd:PRK11730 594 eDKK-GKPKKeVDPAVYELL----APVVQPKREFSDEEIIARMMIPMINEVVRCLEEGIVASPAEADMALVYGLGFPPFR 668

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 233656    160 GGPMFYASTVGLPTVLEKLQKYYRQNpdiPQLEPSDYLKKLASQG 204
Cdd:PRK11730 669 GGAFRYLDTLGVANYVALADKYAHLG---PLYQVPEGLREMAANG 710
 
Name Accession Description Interval E-value
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
4-204 2.55e-28

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 111.88  E-value: 2.55e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 233656      4 VDQVLE-EFGFKMGPFRVSDLAGLDVGwksRKGQGLtgptLLPGTPARKRGNRRycPIPDVLCELGRFGQKTGKGWYQY- 81
Cdd:PRK11730 523 IDKVMEkQFGWPMGPAYLLDVVGIDTA---HHAQAV----MAEGFPDRMKKDYR--DAIDVLFEAKRFGQKNGKGFYRYe 593

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 233656     82 -DKPlGRIHK-PDPWLSTFLsryrKPHHIEPRTISQDEILERCLYSLINEAFRILGEGIAASPEHIDVVYLHGYGCARHK 159
Cdd:PRK11730 594 eDKK-GKPKKeVDPAVYELL----APVVQPKREFSDEEIIARMMIPMINEVVRCLEEGIVASPAEADMALVYGLGFPPFR 668

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 233656    160 GGPMFYASTVGLPTVLEKLQKYYRQNpdiPQLEPSDYLKKLASQG 204
Cdd:PRK11730 669 GGAFRYLDTLGVANYVALADKYAHLG---PLYQVPEGLREMAANG 710
3HCDH pfam00725
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda ...
 1-81 7.67e-20

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda crystallin. Some proteins include two copies of this domain.


Pssm-ID: 395588 [Multi-domain]  Cd Length: 97  Bit Score: 80.72  E-value: 7.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 233656       1 PEEVDQVLEE-FGFKMGPFRVSDLAGLDVGWKSRKGQGLTGPTllpgtparkrGNRRYCPIPDVLCELGRFGQKTGKGWY 79
Cdd:pfam00725  26 PEDIDAAMRLgLGLPMGPFELSDLVGLDVGYHILEVLAEEFGD----------RAYRPPPLLEKLVEAGRLGRKTGKGFY 95


                  ..
gi 233656      80 QY 81
Cdd:pfam00725  96 KY 97
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 1-81 4.24e-19

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 83.24  E-value: 4.24e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 233656     1 PEEVDQVLEE-FGFKMGPFRVSDLAGLDVGWKSRKgqgltgpTLLPGTPARKRgnrRYCPIPDVLCELGRFGQKTGKGWY 79
Cdd:COG1250 210 PEDIDAAMRLgFGFPMGPFELADLVGLDTALAVLE-------VLYEALGDPRY---RPPPLLKKLVEAGRLGRKTGRGFY 279


                ..
gi 233656    80 QY 81
Cdd:COG1250 280 DY 281
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 1-205 5.91e-14

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 70.25  E-value: 5.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 233656       1 PEEVDQVLEEFGFKMGPFRVSDLAGLDVGwkSRKGQGLtgptllpgtpARKRGNRRYCPIPDVLCEL---GRFGQKTGKG 77
Cdd:TIGR02441 542 PKKLDKLTTKFGFPVGAATLADEVGVDVA--EHVAEDL----------GKAFGERFGGGSAELLSELvkaGFLGRKSGKG 609

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 233656      78 WYQYDKPLGRIHKPDPWLSTFLSRYRKPhhIEPRTISQDEILERCLYSLINEAFRILGEGIAASPEHIDVVYLHGYGCAR 157
Cdd:TIGR02441 610 IFIYQEGKKGSKKVNSDADEILAQYKLP--PKAEVSSPEDIQIRLVSRFVNEAVLCLEEGILASPSEGDIGAVFGLGFPP 687

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 233656     158 HKGGPMFYASTVGLPTVLEKLQKY---YRQnpdipQLEPSDYLKKLASQGN 205
Cdd:TIGR02441 688 FLGGPFRFVDLYGADKLVDKMEKYaaaYGV-----QFTPCQLLLDHAKSPG 733
 
Name Accession Description Interval E-value
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
4-204 2.55e-28

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 111.88  E-value: 2.55e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 233656      4 VDQVLE-EFGFKMGPFRVSDLAGLDVGwksRKGQGLtgptLLPGTPARKRGNRRycPIPDVLCELGRFGQKTGKGWYQY- 81
Cdd:PRK11730 523 IDKVMEkQFGWPMGPAYLLDVVGIDTA---HHAQAV----MAEGFPDRMKKDYR--DAIDVLFEAKRFGQKNGKGFYRYe 593

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 233656     82 -DKPlGRIHK-PDPWLSTFLsryrKPHHIEPRTISQDEILERCLYSLINEAFRILGEGIAASPEHIDVVYLHGYGCARHK 159
Cdd:PRK11730 594 eDKK-GKPKKeVDPAVYELL----APVVQPKREFSDEEIIARMMIPMINEVVRCLEEGIVASPAEADMALVYGLGFPPFR 668

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 233656    160 GGPMFYASTVGLPTVLEKLQKYYRQNpdiPQLEPSDYLKKLASQG 204
Cdd:PRK11730 669 GGAFRYLDTLGVANYVALADKYAHLG---PLYQVPEGLREMAANG 710
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
2-204 1.49e-24

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 101.13  E-value: 1.49e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 233656      2 EEVDQVLEEFGFKMGPFRVSDLAGLDVGWKsrkgqglTGPTLLPGTPARKRGnrrycpiPDVLCEL---GRFGQKTGKGW 78
Cdd:PRK11154 518 EHIDAALVKFGFPVGPITLLDEVGIDVGTK-------IIPILEAALGERFSA-------PAAFDKLlndDRKGRKNGRGF 583

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 233656     79 YQYDKPLGRIHK-PDPWLSTFLSryrkphhIEPRT-ISQDEILERCLYSLINEAFRILGEGIAASPEHIDVVYLHGYGCA 156
Cdd:PRK11154 584 YLYGQKGKKSKKqVDESVYPLLG-------ITPQSrLSANEIAERCVMLMLNEAVRCLDEGIIRSARDGDIGAVFGIGFP 656

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 233656    157 RHKGGPMFYASTVGLPTVLEKLQKYYRQNPDipQLEPSDYLKKLASQG 204
Cdd:PRK11154 657 PFLGGPFRYMDSLGAGEVVAILERLAAQYGD--RFTPCERLVEMAERG 702
3HCDH pfam00725
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda ...
 1-81 7.67e-20

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda crystallin. Some proteins include two copies of this domain.


Pssm-ID: 395588 [Multi-domain]  Cd Length: 97  Bit Score: 80.72  E-value: 7.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 233656       1 PEEVDQVLEE-FGFKMGPFRVSDLAGLDVGWKSRKGQGLTGPTllpgtparkrGNRRYCPIPDVLCELGRFGQKTGKGWY 79
Cdd:pfam00725  26 PEDIDAAMRLgLGLPMGPFELSDLVGLDVGYHILEVLAEEFGD----------RAYRPPPLLEKLVEAGRLGRKTGKGFY 95


                  ..
gi 233656      80 QY 81
Cdd:pfam00725  96 KY 97
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 1-81 4.24e-19

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 83.24  E-value: 4.24e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 233656     1 PEEVDQVLEE-FGFKMGPFRVSDLAGLDVGWKSRKgqgltgpTLLPGTPARKRgnrRYCPIPDVLCELGRFGQKTGKGWY 79
Cdd:COG1250 210 PEDIDAAMRLgFGFPMGPFELADLVGLDTALAVLE-------VLYEALGDPRY---RPPPLLKKLVEAGRLGRKTGRGFY 279


                ..
gi 233656    80 QY 81
Cdd:COG1250 280 DY 281
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 1-205 5.91e-14

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 70.25  E-value: 5.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 233656       1 PEEVDQVLEEFGFKMGPFRVSDLAGLDVGwkSRKGQGLtgptllpgtpARKRGNRRYCPIPDVLCEL---GRFGQKTGKG 77
Cdd:TIGR02441 542 PKKLDKLTTKFGFPVGAATLADEVGVDVA--EHVAEDL----------GKAFGERFGGGSAELLSELvkaGFLGRKSGKG 609

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 233656      78 WYQYDKPLGRIHKPDPWLSTFLSRYRKPhhIEPRTISQDEILERCLYSLINEAFRILGEGIAASPEHIDVVYLHGYGCAR 157
Cdd:TIGR02441 610 IFIYQEGKKGSKKVNSDADEILAQYKLP--PKAEVSSPEDIQIRLVSRFVNEAVLCLEEGILASPSEGDIGAVFGLGFPP 687

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 233656     158 HKGGPMFYASTVGLPTVLEKLQKY---YRQnpdipQLEPSDYLKKLASQGN 205
Cdd:TIGR02441 688 FLGGPFRFVDLYGADKLVDKMEKYaaaYGV-----QFTPCQLLLDHAKSPG 733
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 121-204 8.09e-08

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 51.26  E-value: 8.09e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 233656   121 RCLYSLINEAFRILGEGIaASPEHIDVVYLHGYGcarHKGGPMFYASTVGLPTVLEKLQKYYRQNPDiPQLEPSDYLKKL 200
Cdd:COG1250 190 RILVPYLNEAIRLLEEGV-ASPEDIDAAMRLGFG---FPMGPFELADLVGLDTALAVLEVLYEALGD-PRYRPPPLLKKL 264


                ....
gi 233656   201 ASQG 204
Cdd:COG1250 265 VEAG 268
3HCDH pfam00725
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda ...
 118-209 4.39e-07

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda crystallin. Some proteins include two copies of this domain.


Pssm-ID: 395588 [Multi-domain]  Cd Length: 97  Bit Score: 46.44  E-value: 4.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 233656     118 ILERCLYSLINEAFRILGEGIaASPEHIDVVYLHGYGcarHKGGPMFYASTVGLPTVLEKLQKYYRQNPDiPQLEPSDYL 197
Cdd:pfam00725   3 VVNRLLAPYLNEAIRLVEEGV-ATPEDIDAAMRLGLG---LPMGPFELSDLVGLDVGYHILEVLAEEFGD-RAYRPPPLL 77

                          90
                  ....*....|..
gi 233656     198 KKLASQGNPPLK 209
Cdd:pfam00725  78 EKLVEAGRLGRK 89
PRK09260 PRK09260
3-hydroxyacyl-CoA dehydrogenase;
1-82 6.51e-07

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 236434 [Multi-domain]  Cd Length: 288  Bit Score: 48.63  E-value: 6.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 233656      1 PEEVDQVLE-EFGFKMGPFRVSDLagldVGWKSRkgqgLTGPTLLPGTPARKRgnrRYCPIPDVLCELGRFGQKTGKGWY 79
Cdd:PRK09260 210 AEDIDKAIRlGLNFPMGPLELGDL----VGLDTR----LNNLKYLHETLGEKY---RPAPLLEKYVKAGRLGRKTGRGVY 278


                 ...
gi 233656     80 QYD 82
Cdd:PRK09260 279 DYT 281
PRK05808 PRK05808
3-hydroxybutyryl-CoA dehydrogenase; Validated
 121-204 8.26e-07

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 180269 [Multi-domain]  Cd Length: 282  Bit Score: 48.42  E-value: 8.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 233656    121 RCLYSLINEAFRILGEGIaASPEHIDVVYlhGYGCaRHKGGPMFYASTVGLPTVLEKLQKYYRQNPDiPQLEPSDYLKKL 200
Cdd:PRK05808 191 RILIPMINEAIFVLAEGV-ATAEDIDEGM--KLGC-NHPIGPLALADLIGLDTCLAIMEVLYEGFGD-SKYRPCPLLRKM 265


                 ....
gi 233656    201 ASQG 204
Cdd:PRK05808 266 VAAG 269
PRK08268 PRK08268
3-hydroxy-acyl-CoA dehydrogenase; Validated
 1-81 1.01e-06

3-hydroxy-acyl-CoA dehydrogenase; Validated


Pssm-ID: 236211 [Multi-domain]  Cd Length: 507  Bit Score: 48.69  E-value: 1.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 233656      1 PEEVDQVLEE-FGFKMGPFRVSDLAGLDVGwksrkgqgltgptlLPGTPARKR---GNRRYCP--IPDVLCELGRFGQKT 74
Cdd:PRK08268 215 PATIDAILREaAGFRMGPFELMDLIGLDVN--------------HAVMESVYRqfyQEPRFRPslIQQELVAAGRLGRKS 280


                 ....*..
gi 233656     75 GKGWYQY 81
Cdd:PRK08268 281 GQGFYRY 287
PLN02545 PLN02545
3-hydroxybutyryl-CoA dehydrogenase
 114-175 1.14e-04

3-hydroxybutyryl-CoA dehydrogenase


Pssm-ID: 215300 [Multi-domain]  Cd Length: 295  Bit Score: 42.02  E-value: 1.14e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 233656    114 SQDE---ILERCLYSLINEAFRILGEGIaASPEHIDVVYLHGygcARHKGGPMFYASTVGLPTVL 175
Cdd:PLN02545 182 SQDYpgfIVNRILMPMINEAFYALYTGV-ASKEDIDTGMKLG---TNHPMGPLHLADFIGLDTCL 242
PLN02545 PLN02545
3-hydroxybutyryl-CoA dehydrogenase
 15-86 3.49e-04

3-hydroxybutyryl-CoA dehydrogenase


Pssm-ID: 215300 [Multi-domain]  Cd Length: 295  Bit Score: 40.48  E-value: 3.49e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 233656     15 MGPFRVSDLAGLDV------GWKSrkgqGLTGPTLLPgtparkrgnrryCPIPDVLCELGRFGQKTGKGWYQYDKPLG 86
Cdd:PLN02545 227 MGPLHLADFIGLDTclsimkVLHE----GLGDSKYRP------------CPLLVQYVDAGRLGRKSGRGVYHYDGKKR 288
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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