|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-584 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 1022.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 1 MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFQEHGARIKNIREAAEKLGKNVGILLDTKGPEIRTHTMENG 80
Cdd:PRK06354 7 MRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 81 SIELNAGSKLVISMTEVIGTPDKISVTYEGLVHDVNKGSTILLDDGLIGLEVLDVDAVKREIKTKVLNNGTLKNKKGVNV 160
Cdd:PRK06354 87 PIELKTGDEFILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADGELHCKVLVGGVLSNKKGVNF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 161 PGRKCQSSGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQIIPKIENQEGVDNIDAILEVSDGL 240
Cdd:PRK06354 167 PGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKHIPIIAKIEKQEAIDNIDAILELCDGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 241 MVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSY 320
Cdd:PRK06354 247 MVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDY 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 321 PVEAVQTMHNIASRSEEALNYKEILSKRRDQvGMTITDAIGQSVAHTAINLNA-AIVTPTESGHTARMIAKYRPQAPIVA 399
Cdd:PRK06354 327 PVEAVQTMATIAVRIEKDLPYRDILSKRPEF-TTTITNAISQAVSHIALQLDAaAIVTLTKSGATARNVSKYRPKTPILA 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 400 VTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDLIVITAGT-VGESGTTNLMKVHTVGDIIAKG 478
Cdd:PRK06354 406 VTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTlVGESGSTDLMKVHVVGAVVAKG 485
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 479 QGIGRKSAYGPVVVAQNAKEAEqKMTDGAVLVTKSTDRDMITSLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENAT 558
Cdd:PRK06354 486 QGIGRKSVSGKARVAKTAAEVA-KVNEGDILVTPSTDADMIPAIEKAAAIITEEGGLTSHAAVVGLRLGIPVIVGVKNAT 564
|
570 580
....*....|....*....|....*.
gi 3041863 559 SILTDGQDITVDASRGAVYQGRASVL 584
Cdd:PRK06354 565 SLIKDGQIITVDAARGVVYSGHASVL 590
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-471 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 783.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 1 MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFQEHGARIKNIREAAEKLGKNVGILLDTKGPEIRTHTMENG 80
Cdd:COG0469 2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 81 SIELNAGSKLVISMTEVIGTPDKISVTYEGLVHDVNKGSTILLDDGLIGLEVLDVDavKREIKTKVLNNGTLKNKKGVNV 160
Cdd:COG0469 82 PVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVE--GDEVVCEVVNGGVLSSRKGVNL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 161 PGRKCQSSGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAqDIQIIPKIENQEGVDNIDAILEVSDGL 240
Cdd:COG0469 160 PGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGG-RAPIIAKIEKPEAVENLDEIIEASDGI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 241 MVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSY 320
Cdd:COG0469 239 MVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKY 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 321 PVEAVQTMHNIASRSEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNA-AIVTPTESGHTARMIAKYRPQAPIVA 399
Cdd:COG0469 319 PVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAkAIVAFTESGSTARRISRYRPKVPILA 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3041863 400 VTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDLIVITAGT-VGESGTTNLMKVHTV 471
Cdd:COG0469 399 LTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVpVGVPGTTNTLKVHRV 471
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
2-468 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 672.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 2 RKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFQEHGARIKNIREAAEKLGKNVGILLDTKGPEIRTHTMENGS 81
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 82 IELNAGSKLVISMT--EVIGTPDKISVTYEGLVHDVNKGSTILLDDGLIGLEVLDVDAVKreIKTKVLNNGTLKNKKGVN 159
Cdd:TIGR01064 81 VKLKKGDKVIITTDdiKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDK--VICEVLNGGTLKSKKGVN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 160 VPGRKCQSSGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQIIPKIENQEGVDNIDAILEVSDG 239
Cdd:TIGR01064 159 LPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASDG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 240 LMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGS 319
Cdd:TIGR01064 239 IMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 320 YPVEAVQTMHNIASRSEEALNYKEILSKRR--DQVGMTITDAIGQSVAHTAINLNA-AIVTPTESGHTARMIAKYRPQAP 396
Cdd:TIGR01064 319 YPVEAVQMMAKIAKEAEKALAYLTNFNDRKnsDPKPSTITEAIALSAVEAAEKLDAkAIVVLTESGRTARLLSKYRPNAP 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3041863 397 IVAVTVNDSISRKLALVSGVFAES-GQNASSTDEMLEDAVQKSLNSGIVKHGDLI-VITAGTVGESGTTNLMKV 468
Cdd:TIGR01064 399 IIAVTPNERVARQLALYWGVFPFLvDEEPSDTDARVNKALELLKEKGIVKKGDLVvVIQGGPIGGEGGTNTIRV 472
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
1-471 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 669.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 1 MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFQEHGARIKNIREAAEKLGKNVGILLDTKGPEIRTHTMENG 80
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 81 S-IELNAGSKLVISM--TEVIGTPDKISVTYEGLVHDVNKGSTILLDDGLIGLEVLDVDAvKREIKTKVLNNGTLKNKKG 157
Cdd:cd00288 81 KdISLKAGDKFLVTTdpAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDD-DKTLVCEVLNGGVLGSRKG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 158 VNVPGRKCQSSGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHnAQDIQIIPKIENQEGVDNIDAILEVS 237
Cdd:cd00288 160 VNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEK-GKDIKIIAKIENQEGVNNFDEILEAS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 238 DGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAA 317
Cdd:cd00288 239 DGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 318 GSYPVEAVQTMHNIASRSEEALNYKEILSKRRDQV--GMTITDAIGQSVAHTAINLNA-AIVTPTESGHTARMIAKYRPQ 394
Cdd:cd00288 319 GKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTprPTSTTEAVAMSAVRAAFELGAkAIVVLTTSGRTARLVSKYRPN 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 395 APIVAVTVNDSISRKLALVSGVF-----AESGQNASSTDEMLEDAVQKSLNSGIVKHGDLIVITAGTVGESGTTNLMKVH 469
Cdd:cd00288 399 APIIAVTRNEQTARQLHLYRGVYpvlfeEPKPGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRIL 478
|
..
gi 3041863 470 TV 471
Cdd:cd00288 479 TV 480
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
1-345 |
0e+00 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 520.77 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 1 MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFQEHGARIKNIREAAEKLGKNVGILLDTKGPEIRTHTMENG 80
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 81 S--IELNAGSKLVISMTEVI---GTPDKISVTYEGLVHDVNKGSTILLDDGLIGLEVLDVDAVKReIKTKVLNNGTLKNK 155
Cdd:pfam00224 81 KkdIELKAGDEMIVSTDAKYkgaCDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKT-LVVEVLNGGVIGSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 156 KGVNVPGRKCQSSGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNaQDIQIIPKIENQEGVDNIDAILE 235
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAG-KNIQIIAKIENQEGVNNFDEILE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 236 VSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGET 315
Cdd:pfam00224 239 ATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 318
|
330 340 350
....*....|....*....|....*....|
gi 3041863 316 AAGSYPVEAVQTMHNIASRSEEALNYKEIL 345
Cdd:pfam00224 319 AKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-584 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 1022.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 1 MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFQEHGARIKNIREAAEKLGKNVGILLDTKGPEIRTHTMENG 80
Cdd:PRK06354 7 MRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 81 SIELNAGSKLVISMTEVIGTPDKISVTYEGLVHDVNKGSTILLDDGLIGLEVLDVDAVKREIKTKVLNNGTLKNKKGVNV 160
Cdd:PRK06354 87 PIELKTGDEFILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADGELHCKVLVGGVLSNKKGVNF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 161 PGRKCQSSGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQIIPKIENQEGVDNIDAILEVSDGL 240
Cdd:PRK06354 167 PGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKHIPIIAKIEKQEAIDNIDAILELCDGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 241 MVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSY 320
Cdd:PRK06354 247 MVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDY 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 321 PVEAVQTMHNIASRSEEALNYKEILSKRRDQvGMTITDAIGQSVAHTAINLNA-AIVTPTESGHTARMIAKYRPQAPIVA 399
Cdd:PRK06354 327 PVEAVQTMATIAVRIEKDLPYRDILSKRPEF-TTTITNAISQAVSHIALQLDAaAIVTLTKSGATARNVSKYRPKTPILA 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 400 VTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDLIVITAGT-VGESGTTNLMKVHTVGDIIAKG 478
Cdd:PRK06354 406 VTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTlVGESGSTDLMKVHVVGAVVAKG 485
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 479 QGIGRKSAYGPVVVAQNAKEAEqKMTDGAVLVTKSTDRDMITSLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENAT 558
Cdd:PRK06354 486 QGIGRKSVSGKARVAKTAAEVA-KVNEGDILVTPSTDADMIPAIEKAAAIITEEGGLTSHAAVVGLRLGIPVIVGVKNAT 564
|
570 580
....*....|....*....|....*.
gi 3041863 559 SILTDGQDITVDASRGAVYQGRASVL 584
Cdd:PRK06354 565 SLIKDGQIITVDAARGVVYSGHASVL 590
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-471 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 783.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 1 MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFQEHGARIKNIREAAEKLGKNVGILLDTKGPEIRTHTMENG 80
Cdd:COG0469 2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 81 SIELNAGSKLVISMTEVIGTPDKISVTYEGLVHDVNKGSTILLDDGLIGLEVLDVDavKREIKTKVLNNGTLKNKKGVNV 160
Cdd:COG0469 82 PVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVE--GDEVVCEVVNGGVLSSRKGVNL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 161 PGRKCQSSGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAqDIQIIPKIENQEGVDNIDAILEVSDGL 240
Cdd:COG0469 160 PGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGG-RAPIIAKIEKPEAVENLDEIIEASDGI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 241 MVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSY 320
Cdd:COG0469 239 MVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKY 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 321 PVEAVQTMHNIASRSEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNA-AIVTPTESGHTARMIAKYRPQAPIVA 399
Cdd:COG0469 319 PVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAkAIVAFTESGSTARRISRYRPKVPILA 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3041863 400 VTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDLIVITAGT-VGESGTTNLMKVHTV 471
Cdd:COG0469 399 LTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVpVGVPGTTNTLKVHRV 471
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
2-468 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 672.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 2 RKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFQEHGARIKNIREAAEKLGKNVGILLDTKGPEIRTHTMENGS 81
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 82 IELNAGSKLVISMT--EVIGTPDKISVTYEGLVHDVNKGSTILLDDGLIGLEVLDVDAVKreIKTKVLNNGTLKNKKGVN 159
Cdd:TIGR01064 81 VKLKKGDKVIITTDdiKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDK--VICEVLNGGTLKSKKGVN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 160 VPGRKCQSSGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQIIPKIENQEGVDNIDAILEVSDG 239
Cdd:TIGR01064 159 LPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASDG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 240 LMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGS 319
Cdd:TIGR01064 239 IMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 320 YPVEAVQTMHNIASRSEEALNYKEILSKRR--DQVGMTITDAIGQSVAHTAINLNA-AIVTPTESGHTARMIAKYRPQAP 396
Cdd:TIGR01064 319 YPVEAVQMMAKIAKEAEKALAYLTNFNDRKnsDPKPSTITEAIALSAVEAAEKLDAkAIVVLTESGRTARLLSKYRPNAP 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3041863 397 IVAVTVNDSISRKLALVSGVFAES-GQNASSTDEMLEDAVQKSLNSGIVKHGDLI-VITAGTVGESGTTNLMKV 468
Cdd:TIGR01064 399 IIAVTPNERVARQLALYWGVFPFLvDEEPSDTDARVNKALELLKEKGIVKKGDLVvVIQGGPIGGEGGTNTIRV 472
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
1-471 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 669.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 1 MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFQEHGARIKNIREAAEKLGKNVGILLDTKGPEIRTHTMENG 80
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 81 S-IELNAGSKLVISM--TEVIGTPDKISVTYEGLVHDVNKGSTILLDDGLIGLEVLDVDAvKREIKTKVLNNGTLKNKKG 157
Cdd:cd00288 81 KdISLKAGDKFLVTTdpAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDD-DKTLVCEVLNGGVLGSRKG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 158 VNVPGRKCQSSGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHnAQDIQIIPKIENQEGVDNIDAILEVS 237
Cdd:cd00288 160 VNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEK-GKDIKIIAKIENQEGVNNFDEILEAS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 238 DGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAA 317
Cdd:cd00288 239 DGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 318 GSYPVEAVQTMHNIASRSEEALNYKEILSKRRDQV--GMTITDAIGQSVAHTAINLNA-AIVTPTESGHTARMIAKYRPQ 394
Cdd:cd00288 319 GKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTprPTSTTEAVAMSAVRAAFELGAkAIVVLTTSGRTARLVSKYRPN 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 395 APIVAVTVNDSISRKLALVSGVF-----AESGQNASSTDEMLEDAVQKSLNSGIVKHGDLIVITAGTVGESGTTNLMKVH 469
Cdd:cd00288 399 APIIAVTRNEQTARQLHLYRGVYpvlfeEPKPGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRIL 478
|
..
gi 3041863 470 TV 471
Cdd:cd00288 479 TV 480
|
|
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
1-459 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 642.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 1 MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFQEHGARIKNIREAAEKLGKNVGILLDTKGPEIRTHTMENG 80
Cdd:PRK05826 3 LRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKEG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 81 SIELNAGSKLVIS-MTEVIGTPDKISVTYEGLVHDVNKGSTILLDDGLIGLEVLDVDAVkrEIKTKVLNNGTLKNKKGVN 159
Cdd:PRK05826 83 KITLKTGDKFTLDtDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGD--EVETEVKNGGPLSNNKGIN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 160 VPGRKCQSSGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQIIPKIENQEGVDNIDAILEVSDG 239
Cdd:PRK05826 161 IPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAKIIAKIERAEAVDNIDEIIEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 240 LMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGS 319
Cdd:PRK05826 241 IMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 320 YPVEAVQTMHNIASRSEEALNYKEIlSKRRDQVGMTITDAIGQSVAHTAINLN--AAIVTPTESGHTARMIAKYRPQAPI 397
Cdd:PRK05826 321 YPVEAVEAMARICKGAEKEFSINLS-KHRLDRQFDRIDEAIAMSAMYAANHLKgvKAIVALTESGRTARLISRFRPGAPI 399
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3041863 398 VAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDLIVITAGTVGE 459
Cdd:PRK05826 400 FAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMG 461
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
1-471 |
0e+00 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 622.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 1 MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFQEHGARIKNIREAAEKLGKNVGILLDTKGPEIRTHTMENG 80
Cdd:PRK09206 1 MKKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 81 S-IELNAGSKLVISM-TEVIGTPDKISVTYEGLVHDVNKGSTILLDDGLIGLEVLDVDAvkREIKTKVLNNGTLKNKKGV 158
Cdd:PRK09206 81 NdVSLKAGQTFTFTTdKSVVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITG--NEVICKVLNNGDLGENKGV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 159 NVPGRKCQSSGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQIIPKIENQEGVDNIDAILEVSD 238
Cdd:PRK09206 159 NLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGENIQIISKIENQEGLNNFDEILEASD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 239 GLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAG 318
Cdd:PRK09206 239 GIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 319 SYPVEAVQTMHNIASRSEEALNYKeiLSKRRDQVGMTITDAIGQSVAHTAINLNA-AIVTPTESGHTARMIAKYRPQAPI 397
Cdd:PRK09206 319 KYPLEAVSIMATICERTDRVMNSR--LESNNDNRKLRITEAVCRGAVETAEKLDApLIVVATQGGKSARSVRKYFPDATI 396
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3041863 398 VAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDLIVITAGTVGESGTTNLMKVHTV 471
Cdd:PRK09206 397 LALTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVVMVSGALVPSGTTNTASVHVL 470
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
1-345 |
0e+00 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 520.77 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 1 MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFQEHGARIKNIREAAEKLGKNVGILLDTKGPEIRTHTMENG 80
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 81 S--IELNAGSKLVISMTEVI---GTPDKISVTYEGLVHDVNKGSTILLDDGLIGLEVLDVDAVKReIKTKVLNNGTLKNK 155
Cdd:pfam00224 81 KkdIELKAGDEMIVSTDAKYkgaCDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKT-LVVEVLNGGVIGSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 156 KGVNVPGRKCQSSGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNaQDIQIIPKIENQEGVDNIDAILE 235
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAG-KNIQIIAKIENQEGVNNFDEILE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 236 VSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGET 315
Cdd:pfam00224 239 ATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 318
|
330 340 350
....*....|....*....|....*....|
gi 3041863 316 AAGSYPVEAVQTMHNIASRSEEALNYKEIL 345
Cdd:pfam00224 319 AKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
2-472 |
3.45e-176 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 507.16 E-value: 3.45e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 2 RKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFQEHGARIKNIREAAEKLGKNVGILLDTKGPEIRTHTMENGS 81
Cdd:PRK06247 5 RRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFADGK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 82 IELNAGSKLVISMTEVIGTPDKISVTYEGLVHDVNKGSTILLDDGLIGLEVLDVDAvkREIKTKVLNNGTLKNKKGVNVP 161
Cdd:PRK06247 85 VQLANGQTFRLDVDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDG--DDVVCRVVEGGPVSDRKGVSLP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 162 GRKCQSSGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAqdiqIIPKIENQEGVDNIDAILEVSDGLM 241
Cdd:PRK06247 163 GTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGRVP----VMAKIEKPQAIDRLEAIVEASDAIM 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 242 VARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYP 321
Cdd:PRK06247 239 VARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 322 VEAVQTMHNIASRSEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNA-AIVTPTESGHTARMIAKYRPQAPIVAV 400
Cdd:PRK06247 319 VEAVRTMARIIRQVERDPTYPPLIHAQRPQPEATKRDAISYAARDIAERLDLaALVAYTSSGDTALRAARERPPLPILAL 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3041863 401 TVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDLIVITAGT-VGESGTTNLMKVHTVG 472
Cdd:PRK06247 399 TPNPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVpPGTPGSTNMLRIAYIG 471
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
3-451 |
3.10e-165 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 480.24 E-value: 3.10e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 3 KTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFQEHGARIKNIREAAEKLGKNVGILLDTKGPEIRTHTMENGS- 81
Cdd:PLN02461 22 KTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFLKDGKp 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 82 IELNAGSKLVISMT-EVIGTPDKISVTYEGLVHDVNKGSTILLDDGLIGLEVLDVDAVKREIKTKVLNNGTLKNKKGVNV 160
Cdd:PLN02461 102 VQLKQGQEITITTDySIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEAGTVRCRCENSAMLGERKNVNL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 161 PGRKCQSSGITEKDARDIV-FGIEQGVDFIAPSFIRRSTDVLEIRELLEEHnAQDIQIIPKIENQEGVDNIDAILEVSDG 239
Cdd:PLN02461 182 PGVVVDLPTLTEKDKEDILqWGVPNKIDFIALSFVRKGSDLVEVRKVLGEH-AKSILLISKVENQEGLDNFDDILAESDA 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 240 LMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGS 319
Cdd:PLN02461 261 FMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETAAGA 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 320 YPVEAVQTMHNIASRSEEALNY----KEILskRRDQVGMTITDAIGQSVAHTAINLNAA-IVTPTESGHTARMIAKYRPQ 394
Cdd:PLN02461 341 YPELAVKTMARICREAEASLDYgalfKEIM--RSAPLPMSPLESLASSAVRTANKVKASlIVVLTRGGTTARLVAKYRPA 418
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3041863 395 APIVAVTV-------------NDSISRKLALVSG---VFAESGQNAS---STDEMLEDAVQKSLNSGIVKHGDLIV 451
Cdd:PLN02461 419 VPILSVVVpeittdsfdwscsDEAPARHSLIYRGlipVLAEGSAKATdseSTEEILEAAIEHAKKKGLCKPGDSVV 494
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
266-584 |
1.11e-156 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 451.28 E-value: 1.11e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 266 KCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASRSEEALNYKEIL 345
Cdd:COG3848 1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 346 SKRRDQVGMTITDAIGQSVAHTAINLNA-AIVTPTESGHTARMIAKYRPQAPIVAVTVNDSISRKLALVSGVFAESGQNA 424
Cdd:COG3848 81 VPRAKESSTTITDAISHAVATTAADLGAaAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEES 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 425 SSTDEMLEDAVQKSLNSGIVKHGDLIVITAGT-VGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKM 503
Cdd:COG3848 161 ASTDEMFAVAVALALEAGLVKDGDLVVITAGVpVGVSGTTNLLKVHVVGDVLAKGQGIGRGSVTGKAVVARSAEEALEKF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 504 TDGAVLVTKSTDRDMITSLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQDITVDASRGAVYQGRASV 583
Cdd:COG3848 241 EEGDILVVPSTDAEFVPAIEKAAGIITEEGGLTSHAAIVGLELGIPVIVGAEGATEILKDGQVVTVDAERGVVYRGAVNV 320
|
.
gi 3041863 584 L 584
Cdd:COG3848 321 L 321
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
2-471 |
9.90e-150 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 440.74 E-value: 9.90e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 2 RKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFQEHGARIKNIREAAEKL-GKNVGILLDTKGPEIRTHTMENG 80
Cdd:PTZ00066 38 KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKARpNANLGILLDTKGPEIRTGFLKNH 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 81 S-IELNAGSKLVISMT-EVIGTPDKISVTYEGLVHDVNKGSTILLDDGLIGLEVLDVDavKREIKTKVLNNGTLKNKKGV 158
Cdd:PTZ00066 118 KpITLKEGQTLKITTDyTFLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVH--DDYIITKVLNNATIGERKNM 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 159 NVPGRKCQSSGITEKDARDIV-FGIEQGVDFIAPSFIRRSTDVLEIRELLEEHnAQDIQIIPKIENQEGVDNIDAILEVS 237
Cdd:PTZ00066 196 NLPGVKVELPVIGEKDKNDILnFAIPMGCDFIALSFVQSADDVRLCRQLLGER-GRHIKIIPKIENIEGLINFDEILAES 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 238 DGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAA 317
Cdd:PTZ00066 275 DGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETAN 354
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 318 GSYPVEAVQTMHNIASRSEEALNYKEILSKRRDQVGMTITD--AIGQSVAHTAINLNAA-IVTPTESGHTARMIAKYRPQ 394
Cdd:PTZ00066 355 GKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTPVSVqeAVARSAVETAEDINAKlIIALTETGNTARLISKYRPS 434
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 3041863 395 APIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDLIVITAGTVGE-SGTTNLMKVHTV 471
Cdd:PTZ00066 435 CTILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEvAGSSNLMKVVKI 512
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
28-452 |
2.14e-123 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 371.31 E-value: 2.14e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 28 MNVARLNFSHGDFQEHGARIKNIREAAEKLGKNVGILLDTKGPEIRTHTMENGSIELNAGSKLVISMT---EVIGTPDKI 104
Cdd:PTZ00300 1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGATCYVTTDpafADKGTKDKF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 105 SVTYEGLVHDVNKGSTILLDDGLIGLEVLDVDAvKREIKTKVLNNGTLKNKKGVNVPGRKCQSSGITEKDARDIVFGIEQ 184
Cdd:PTZ00300 81 YIDYQNLSKVVRPGGYIYIDDGILILHVQSHED-EQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 185 GVDFIAPSFIRRSTDVLEIRELLEEhNAQDIQIIPKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELI 264
Cdd:PTZ00300 160 GVDMIFASFIRSAEQVGEVRKALGA-KGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 265 KKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASRSEEALNYKEI 344
Cdd:PTZ00300 239 SKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEYVF 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 345 LS--KRRDQVGMTITDAIGQSVAHTAINLNA-AIVTPTESGHTARMIAKYRPQAPIVAVTVNDSISRKLALVSG---VFA 418
Cdd:PTZ00300 319 FNsiKKLQPIPMSAEEAVCSSAVNSVYETKAkALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGvesVFF 398
|
410 420 430
....*....|....*....|....*....|....*...
gi 3041863 419 ESGQNASstDEMLEDAVQKSL----NSGIVKHGDLIVI 452
Cdd:PTZ00300 399 DAERLGH--DEGKEQRVAMGVgfakSKGYVQSGDLMVV 434
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
2-452 |
2.58e-120 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 367.72 E-value: 2.58e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 2 RKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFQEHGARIKNIREAAEKLGKNV-GILLDTKGPEIRTHTMENg 80
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDNViAIMLDTKGPEVRSGDLPQ- 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 81 SIELNAGSKLVISMTEVIGTPDKISVTYEGLVHDVNKGSTILLDDGLIGLEVldVDAVKREIKTKVLNNGTLKNKKGVNV 160
Cdd:PLN02623 189 PIMLEEGQEFTFTIKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAV--KSKTSDSVKCEVVDGGELKSRRHLNV 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 161 PGRKCQSSGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAqDIQIIPKIENQEGVDNIDAILEVSDGL 240
Cdd:PLN02623 267 RGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNA-DIHVIVKIESADSIPNLHSIITASDGA 345
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 241 MVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSY 320
Cdd:PLN02623 346 MVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKF 425
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 321 PVEAVQTMHNIASRSEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAIVTPTESGHTARMIAKYRPQAPIVAV 400
Cdd:PLN02623 426 PLKAVKVMHTVALRTEATLPEGTTPPNLGQAFKNHMSEMFAFHATMMANTLGTSIIVFTRTGFMAILLSHYRPSGTIFAF 505
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 3041863 401 TVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDLIVI 452
Cdd:PLN02623 506 TNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEVAL 557
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
4-473 |
9.36e-108 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 333.56 E-value: 9.36e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 4 TKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFQEHGARIKNIREAAEKLGKNVGILLDTKGPEIRTHTMENGSIE 83
Cdd:PLN02765 30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVINKTEKPIS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 84 LNAGSKLVIsmtevigTPDK--------ISVTYEGLVHDVNKGSTILLDDGL--------IGLEVLDVDAvkREIKTKVL 147
Cdd:PLN02765 110 LKAGNTVTL-------TPDQskeassevLPINFPGLAKAVKPGDTIFVGQYLftgsettsVWLEVDEVKG--DDVVCTVK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 148 NNGTLK--------NKKGVNVPGrkcqssgITEKDARDI-VFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII 218
Cdd:PLN02765 181 NSATLAgslftlhvSQVRIDLPT-------LSEKDKEVIsTWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLSQTQIF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 219 PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITaTQMLDSMQRNPRPTRAEASDV 298
Cdd:PLN02765 254 AKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDV 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 299 ANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASRSEEALNYKEILSKRRDQVG--MTITDAIGQSVAHTAINLNAA-I 375
Cdd:PLN02765 333 ANAVLDGADAILLGAETLRGLYPVETISTVGRICAEAEKVFNQDLYFKKTVKYVGepMSHLESIASSAVRAAIKVKASvI 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 376 VTPTESGHTARMIAKYRPQAPIVAVTV----NDSI---------SRKLALVSGVFA------ESGQNASSTDE-MLEDAV 435
Cdd:PLN02765 413 IVFTSSGRAARLIAKYRPTMPVLSVVIprlkTNQLkwsftgafqARQCLIVRGLFPmladprHSAESTSATNEsVLKVAL 492
|
490 500 510
....*....|....*....|....*....|....*...
gi 3041863 436 QKSLNSGIVKHGDLIVITAGTvgesGTTNLMKVHTVGD 473
Cdd:PLN02765 493 DHGKAAGVIKSHDRVVVCQKV----GDSSVVKIIELDD 526
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
1-471 |
8.22e-96 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 302.05 E-value: 8.22e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 1 MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFQEHGARIKNIREAAEKLGKNVGILLDTKGPEIrtHTMENG 80
Cdd:PLN02762 24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEI--HMGDLG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 81 ---SIELNAGSKLVISMTEVIGTPDK--ISVTYEGLVHDVNKGSTILLDDGLIGLEVldVDAVKREIKTKVLNNGTLKNK 155
Cdd:PLN02762 102 gasSAKAEDGEEWTFTVRKFDGSRPEftIQVNYDGFAEDVKVGDELVVDGGMVRFEV--IEKIGPDVKCKCTDPGLLLPR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 156 KGVN-------VPGRKCQSSGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQ-DIQIIPKIENQEGV 227
Cdd:PLN02762 180 ANLTfwrdgslVRERNAMLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRDsDIGVIAKIESLDSL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 228 DNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTD 307
Cdd:PLN02762 260 KNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRAD 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 308 AIMLSGETAAGSYPVEAVQTMHNIASRSEE---ALNYKEILSKRrdQVGMTITDAIGQ----SVAHTAINLNA-AIVTPT 379
Cdd:PLN02762 340 ALMLSGESAMGLYPEKALSVLRSVSLRMELwsrEEKRHEALELP--QLSSSLSDRISEeicnSAAKMANNLGVdAIFVYT 417
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 380 ESGHTARMIAKYRPQAPIVAVTVNDSISRKLALVSGVFAesgQNASSTDEMlEDAVQKSLN----SGIVKHGDLIVITAg 455
Cdd:PLN02762 418 KHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIP---FRLDFSDDM-ESNLNKTFSllkaRGMIKSGDLVIAVS- 492
|
490
....*....|....*.
gi 3041863 456 TVGESGTTNLMKVHTV 471
Cdd:PLN02762 493 DLTPSSMLQSIQVRNV 508
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
7-336 |
2.52e-95 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 295.32 E-value: 2.52e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 7 VCTIGPASESIEMLTKLMESGMNVARLNFSHGDFQEHgariKNIREAAEKLGKNVGILLDTKGPEIRTHTMENGSIELNA 86
Cdd:PRK06739 6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESH----KDIIRLVKSLDDSIKILGDVQGPKIRLGEIKGEQITLQA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 87 GSKLVISMTEVIGTPDKISVTYEGLVHDVNKGSTILLDDGLIGLEVLDVDAVKreIKTKVLNNGTLKNKKGVNVPGRKCQ 166
Cdd:PRK06739 82 GDSFILHTQPVTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDK--IETKVKTGGNISSHKGVNLPGAIVR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 167 SSGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQIIPKIENQEGVDNIDAILEVSDGLMVARGD 246
Cdd:PRK06739 160 LPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSPNLIAKIETMEAIENFQDICKEADGIMIARGD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 247 LGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQ 326
Cdd:PRK06739 240 LGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVS 319
|
330
....*....|
gi 3041863 327 TMHNIASRSE 336
Cdd:PRK06739 320 TLRLVSEFAE 329
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
2-334 |
1.25e-42 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 159.80 E-value: 1.25e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 2 RKTKIVCTI-GPASESIEMLTKLMESGMNVARLNFSHGDFQEHGARIKNIREAAEKLGKNVGILLDTKGPEIRTHT--ME 78
Cdd:PRK08187 133 RRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGAvaGP 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 79 NGSIELNAGSKLVISMT----EVIGTPDKISVTYEGLVHDVNKGSTILLDDGLIGLEVLDVDAVKREIK-TKVLNNGT-L 152
Cdd:PRK08187 213 LGKTRLYTGDRLALVAQgpprRIDEEHFQVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLEvTHARPKGLkL 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 153 KNKKGVNVPGRKCQSSGITEKDARDIVFGIEQGvDFIAPSFIRRSTDVLEIRELLEE---HNAQDIQIIPKIENQEGVDN 229
Cdd:PRK08187 293 KPEKGLNFPDTALDLPALTEKDRADLDFVARHA-DLVGYSFVQSPGDVEALQAALAArrpDDWRKLGLVLKIETPRAVAN 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 230 IDAILEVSDG-----LMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAifD 304
Cdd:PRK08187 372 LPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAMA--A 449
|
330 340 350
....*....|....*....|....*....|
gi 3041863 305 GTDAIMLSgetaAGSYPVEAVQTMHNIASR 334
Cdd:PRK08187 450 RAECVMLN----KGPYLVEAVTFLDDLLAR 475
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
358-469 |
4.94e-42 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 146.86 E-value: 4.94e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 358 DAIGQSVAHTAINLNA-AIVTPTESGHTARMIAKYRPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQ 436
Cdd:pfam02887 1 EAIAHAAVEAAEELGAkAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVK 80
|
90 100 110
....*....|....*....|....*....|....
gi 3041863 437 KSLNSGIVKHGDLIVITAGT-VGESGTTNLMKVH 469
Cdd:pfam02887 81 VAKEAGLVKKGDLVVITAGVpFGVSGTTNTLKVI 114
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
2-337 |
5.68e-42 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 159.73 E-value: 5.68e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 2 RKTKIVCTI-GPASESIEMLTKLMESGMNVARLNFSHGDFQEHGARIKNIREAAEKLGKNVGILLDTKGPEIRTHTMENG 80
Cdd:PRK14725 139 RPTRIMVTLpTEAADDPDLVRRLLAAGMDIARINCAHDDPEAWRAMIANVRTAEEELGRRCRIAMDLAGPKLRTGPIAPG 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 --------------------------------------------------------------------------------
Cdd:PRK14725 219 prviklrptrdalgrvltparlwltasespppspppgpvglpvdpewlarlepgdelrftdargkkrkltvtevddegvl 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 81 ---------------------------------SIELNAGSKLVISMTEVIGTPD-------KISVTYEGLVHDVNKGST 120
Cdd:PRK14725 299 aegsqtaylangtllrlgrhdstrvgglppveqKLRLKVGDRLVLTRDDAPGDPAqgdappaRISCTLPEAFRAARVGER 378
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 121 ILLDDGLIGLEVLDVDAvkREIKTKVLNNG----TLKNKKGVNVPGRKCQSSGITEKDARDIVFgIEQGVDFIAPSFIRR 196
Cdd:PRK14725 379 VWFDDGKIGAVVVKVEA--DEVELRITHARpggsKLKAGKGINLPDSHLPLPALTDKDLEDLAF-VAKHADIVALSFVRS 455
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 197 STDVLEIRELLEEHNAQDIQIIPKIENQEGVDNIDAIL-----EVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALG 271
Cdd:PRK14725 456 PEDVRLLLDALEKLGADDLGVVLKIETRRAFENLPRILleamrHPRFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAH 535
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3041863 272 KPVITATQMLDSMQRNPRPTRAEASDVANAIfdGTDAIMLSgetaAGSYPVEAVQTMHNIASRSEE 337
Cdd:PRK14725 536 VPVIWATQVLESLAKKGLPSRAEITDAAMAL--RAECVMLN----KGPHIVEAVRVLDDILRRMEE 595
|
|
| PRK06464 |
PRK06464 |
phosphoenolpyruvate synthase; Validated |
472-580 |
4.03e-29 |
|
phosphoenolpyruvate synthase; Validated
Pssm-ID: 235809 [Multi-domain] Cd Length: 795 Bit Score: 122.93 E-value: 4.03e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 472 GDIIAKGQGIGRKSAYGPVVVAQNAKEAEqKMTDGAVLVTKSTDRDMITSLEKASALITEEGGLTSHAAVVGLSLGIPVI 551
Cdd:PRK06464 353 GKVLVEGRAIGPGIGSGKVRVILDISEMD-KVQPGDVLVTDMTDPDWEPVMKRASAIVTNRGGRTCHAAIIARELGIPAV 431
|
90 100 110
....*....|....*....|....*....|..
gi 3041863 552 VGLENATSILTDGQDITV---DASRGAVYQGR 580
Cdd:PRK06464 432 VGTGNATEVLKDGQEVTVscaEGDTGYVYEGL 463
|
|
| PEP_synth |
TIGR01418 |
phosphoenolpyruvate synthase; Also called pyruvate,water dikinase and PEP synthase. The member ... |
467-581 |
9.50e-29 |
|
phosphoenolpyruvate synthase; Also called pyruvate,water dikinase and PEP synthase. The member from Methanococcus jannaschii contains a large intein. This enzyme generates phosphoenolpyruvate (PEP) from pyruvate, hydrolyzing ATP to AMP and releasing inorganic phosphate in the process. The enzyme shows extensive homology to other enzymes that use PEP as substrate or product. This enzyme may provide PEP for gluconeogenesis, for PTS-type carbohydrate transport systems, or for other processes. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273612 [Multi-domain] Cd Length: 786 Bit Score: 121.77 E-value: 9.50e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 467 KVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEqKMTDGAVLVTKSTDRDMITSLEKASALITEEGGLTSHAAVVGLSL 546
Cdd:TIGR01418 347 ELKGKGKVLVTGRAAGPGIASGKVKVIFDLKEMD-KFEEGDILVTDMTDPDWEPAMKRASAIVTNEGGMTCHAAIVAREL 425
|
90 100 110
....*....|....*....|....*....|....*...
gi 3041863 547 GIPVIVGLENATSILTDGQDITVDASR---GAVYQGRA 581
Cdd:TIGR01418 426 GIPAVVGTGDATKTLKDGMEVTVDCAEgdtGYVYAGKL 463
|
|
| PpsA |
COG0574 |
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and ... |
472-576 |
2.18e-28 |
|
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Phosphoenolpyruvate synthase/pyruvate phosphate dikinase is part of the Pathway/BioSystem: Gluconeogenesis
Pssm-ID: 440339 [Multi-domain] Cd Length: 455 Bit Score: 118.39 E-value: 2.18e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 472 GDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKmTDGAVLVTKSTDRDMITSLEKASALITEEGGLTSHAAVVGLSLGIPVI 551
Cdd:COG0574 351 GEVLAKGLPASPGAASGKVVFIADEAELARF-QEGVILVRDETDPDDVPGMKAAAGIVTERGGMTSHAAIVARELGIPAV 429
|
90 100
....*....|....*....|....*
gi 3041863 552 VGLENATSILTDGQDITVDASRGAV 576
Cdd:COG0574 430 VGCGDATRVLKDGDEITVDGTTGEV 454
|
|
| PEP-utilizers |
pfam00391 |
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain ... |
502-574 |
9.29e-25 |
|
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain which is thought to be mobile in all proteins known to contain it.
Pssm-ID: 459796 [Multi-domain] Cd Length: 73 Bit Score: 97.48 E-value: 9.29e-25
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3041863 502 KMTDGAVLVTKSTDRDMITSLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQDITVDASRG 574
Cdd:pfam00391 1 KLPEGVILVAPDTTPSDTAGLDKAAGIVTERGGMTSHAAIVARELGIPAVVGVGDATILLKEGDLVTVDGSTG 73
|
|
| PRK06241 |
PRK06241 |
phosphoenolpyruvate synthase; Validated |
488-576 |
8.24e-15 |
|
phosphoenolpyruvate synthase; Validated
Pssm-ID: 235751 [Multi-domain] Cd Length: 871 Bit Score: 78.01 E-value: 8.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 488 GPVVVAQNAKEAeqKMTDGAVLVTKSTDRDMITSLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQDI 567
Cdd:PRK06241 780 GRARVILNPEDA--DLEKGDILVTAFTDPGWTPLFVSIKGLVTEVGGLMTHGAVIAREYGIPAVVGVENATKLIKDGQRI 857
|
....*....
gi 3041863 568 TVDASRGAV 576
Cdd:PRK06241 858 RVDGTEGYV 866
|
|
| PRK05878 |
PRK05878 |
pyruvate phosphate dikinase; Provisional |
475-579 |
5.28e-14 |
|
pyruvate phosphate dikinase; Provisional
Pssm-ID: 235635 [Multi-domain] Cd Length: 530 Bit Score: 74.78 E-value: 5.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 475 IAKG----QGIGRKSAYGPVVVAQNAKEAEQkmtdGAVLVTKSTDRDMITSLEKASALITEEGGLTSHAAVVGLSLGIPV 550
Cdd:PRK05878 350 LAKGlpacPGVVSGTAYTDVDEALDAADRGE----PVILVRDHTRPDDVHGMLAAQGIVTEVGGATSHAAVVSRELGRVA 425
|
90 100
....*....|....*....|....*....
gi 3041863 551 IVGLENATSILTDGQDITVDASRGAVYQG 579
Cdd:PRK05878 426 VVGCGAGVAAALAGKEITVDGYEGEVRQG 454
|
|
| PRK08296 |
PRK08296 |
hypothetical protein; Provisional |
488-576 |
1.52e-13 |
|
hypothetical protein; Provisional
Pssm-ID: 181362 Cd Length: 603 Bit Score: 73.54 E-value: 1.52e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3041863 488 GPVVVAQNAKEAEQkMTDGAVLVTKSTDRDMITSLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQDI 567
Cdd:PRK08296 512 GPARVIRSADELSE-VQEGEILVCPVTSPSWAPIFAKIKATVTDIGGVMSHAAIVCREYGLPAVVGTGNATKRIKTGQRL 590
|
....*....
gi 3041863 568 TVDASRGAV 576
Cdd:PRK08296 591 RVDGTKGVV 599
|
|
| PtsA |
COG1080 |
Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate ... |
523-577 |
3.38e-11 |
|
Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism];
Pssm-ID: 440698 [Multi-domain] Cd Length: 571 Bit Score: 65.87 E-value: 3.38e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 3041863 523 EKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQDITVDASRGAVY 577
Cdd:COG1080 173 SRVAGFVTDLGGRTSHTAILARSLGIPAVVGLGDALLLVKDGDLVIVDGDAGVVI 227
|
|
| PRK05865 |
PRK05865 |
sugar epimerase family protein; |
498-576 |
1.75e-07 |
|
sugar epimerase family protein;
Pssm-ID: 235630 [Multi-domain] Cd Length: 854 Bit Score: 54.28 E-value: 1.75e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3041863 498 EAEQKMTDGAVLVTKSTDRDMITSLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQDITVDASRGAV 576
Cdd:PRK05865 756 ETIDDLQPGEILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFGFPCVVDAQGATRFLPPGALVEVDGATGEI 834
|
|
| PRK11177 |
PRK11177 |
phosphoenolpyruvate-protein phosphotransferase PtsI; |
522-577 |
7.25e-05 |
|
phosphoenolpyruvate-protein phosphotransferase PtsI;
Pssm-ID: 183017 [Multi-domain] Cd Length: 575 Bit Score: 45.77 E-value: 7.25e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 3041863 522 LEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQDITVDASRGAVY 577
Cdd:PRK11177 173 LKKVLGFITDIGGRTSHTSIMARSLELPAIVGTGNITKQVKNGDYLILDAVNNQIY 228
|
|
| PRK10558 |
PRK10558 |
alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional |
214-274 |
2.66e-03 |
|
alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional
Pssm-ID: 182547 Cd Length: 256 Bit Score: 39.72 E-value: 2.66e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3041863 214 DIQIIPKIENQEGVDNIDAILEVS--DGLMVARGDLGVEI-----PAE-EVPLVQKELIKKCNALGKPV 274
Cdd:PRK10558 145 NITVLVQIESQQGVDNVDAIAATEgvDGIFVGPSDLAAALghlgnASHpDVQKAIQHIFARAKAHGKPS 213
|
|
| |
