|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
312-695 |
6.24e-161 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 471.17 E-value: 6.24e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 312 MRSWEESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYIsrlppmsEENETEGPY 391
Cdd:COG0513 1 MMSFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRL-------DPSRPRAPQ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 392 AVVMAPTRELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDE 471
Cdd:COG0513 74 ALILAPTRELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVETLVLDE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 472 ADRMIDMGFEPQVAGVLDAMPSSnlkpeneeeeldekkiyRTTYMFSATMPPGVERLARKYLRNPVVVTIGTAGKTTDLI 551
Cdd:COG0513 154 ADRMLDMGFIEDIERILKLLPKE-----------------RQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETI 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 552 SQHVIMMKESEKFFRLQKLLDELGEKTAIVFVNTKKNCDSIAKNLDKAGYRVTTLHGGKSQEQREISLEGFRAKRYNVLV 631
Cdd:COG0513 217 EQRYYLVDKRDKLELLRRLLRDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLV 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1707017 632 ATDVVGRGIDIPDVAHVINYDMPKHIEMYTHRIGRTGRAGKSGVATSFLTLHDTEVFYDLKQML 695
Cdd:COG0513 297 ATDVAARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAIEKLI 360
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
324-540 |
4.30e-141 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 412.48 E-value: 4.30e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 324 LLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRLPPMSEENETEGPYAVVMAPTRELAQ 403
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPLDEETKDDGPYALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 404 QIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEADRMIDMGFEPQ 483
Cdd:cd17945 81 QIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMIDMGFEPQ 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 484 VAGVLDAMPSSNLKP---ENEEEELDEKKIYRTTYMFSATMPPGVERLARKYLRNPVVVT 540
Cdd:cd17945 161 VTKILDAMPVSNKKPdteEAEKLAASGKHRYRQTMMFTATMPPAVEKIAKGYLRRPVVVT 220
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
305-706 |
8.25e-112 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 349.46 E-value: 8.25e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 305 GSRIPRPMRSWEESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRLPPMsee 384
Cdd:PTZ00110 122 GENVPKPVVSFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIVHINAQPLL--- 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 385 NETEGPYAVVMAPTRELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQC 464
Cdd:PTZ00110 199 RYGDGPIVLVLAPTRELAEQIREQCNKFGASSKIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLESNVTNLRRV 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 465 NYVVLDEADRMIDMGFEPQVAGVLdampsSNLKPEneeeeldekkiyRTTYMFSATMPPGVERLARKYLRN-PVVVTIGT 543
Cdd:PTZ00110 279 TYLVLDEADRMLDMGFEPQIRKIV-----SQIRPD------------RQTLMWSATWPKEVQSLARDLCKEePVHVNVGS 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 544 AG-KTTDLISQHVIMMKESEKFFRLQKLLDELGEKTA--IVFVNTKKNCDSIAKNLDKAGYRVTTLHGGKSQEQREISLE 620
Cdd:PTZ00110 342 LDlTACHNIKQEVFVVEEHEKRGKLKMLLQRIMRDGDkiLIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLN 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 621 GFRAKRYNVLVATDVVGRGIDIPDVAHVINYDMPKHIEMYTHRIGRTGRAGKSGVATSFLTLHDTEVFYDLKQMLVQSNS 700
Cdd:PTZ00110 422 EFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTPDKYRLARDLVKVLREAKQ 501
|
....*.
gi 1707017 701 AVPPEL 706
Cdd:PTZ00110 502 PVPPEL 507
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
320-716 |
8.90e-94 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 299.41 E-value: 8.90e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 320 LTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYI--SRLppmseeneteGPYAVVMAP 397
Cdd:PRK11776 11 LPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLdvKRF----------RVQALVLCP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 398 TRELAQQIEEETVKFAHYL-GFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEADRMI 476
Cdd:PRK11776 81 TRELADQVAKEIRRLARFIpNIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDLDALNTLVLDEADRML 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 477 DMGFEPQVAGVLDAMPSSnlkpeneeeeldekkiyRTTYMFSATMPPGVERLARKYLRNPVVVTIGTAGKTTDlISQHVI 556
Cdd:PRK11776 161 DMGFQDAIDAIIRQAPAR-----------------RQTLLFSATYPEGIAAISQRFQRDPVEVKVESTHDLPA-IEQRFY 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 557 MMKESEKFFRLQKLLDELGEKTAIVFVNTKKNCDSIAKNLDKAGYRVTTLHGGKSQEQREISLEGFRAKRYNVLVATDVV 636
Cdd:PRK11776 223 EVSPDERLPALQRLLLHHQPESCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVA 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 637 GRGIDIPDVAHVINYDMPKHIEMYTHRIGRTGRAGKSGVATSFLTLHDTEVFYDLKQML-VQSNSAVPPELARHEASRFK 715
Cdd:PRK11776 303 ARGLDIKALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVAPEEMQRANAIEDYLgRKLNWEPLPSLSPLSGVPLL 382
|
.
gi 1707017 716 P 716
Cdd:PRK11776 383 P 383
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
324-540 |
3.86e-87 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 272.39 E-value: 3.86e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 324 LLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRlppmSEENETEGPYAVVMAPTRELAQ 403
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLP----EPKKKGRGPQALVLAPTRELAM 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 404 QIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEADRMIDMGFEPQ 483
Cdd:cd00268 77 QIAEVARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMGFEED 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1707017 484 VAGVLDAMPSSnlkpeneeeeldekkiyRTTYMFSATMPPGVERLARKYLRNPVVVT 540
Cdd:cd00268 157 VEKILSALPKD-----------------RQTLLFSATLPEEVKELAKKFLKNPVRIE 196
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
213-685 |
1.62e-85 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 278.33 E-value: 1.62e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 213 LFGRGfragmdrREQKKQAAKHEKEMRDEIRKKDGIVEKPEEAAAQRVREEAADTydsfdMRVDRHWSDKRLEEMTErdW 292
Cdd:PRK01297 8 IFGKG-------EAEQPAPAPPSPAAAPAPPPPAKTAAPATKAAAPAAAAPRAEK-----PKKDKPRRERKPKPASL--W 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 293 RIfrEDFNISykgsriPRPMRS-WEESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPM 371
Cdd:PRK01297 74 KL--EDFVVE------PQEGKTrFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISI 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 372 LAYISRLPPMSEENETEgPYAVVMAPTRELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQgLKITQG--CEIVIATPGR 449
Cdd:PRK01297 146 INQLLQTPPPKERYMGE-PRALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQ-LKQLEArfCDILVATPGR 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 450 LIDCLERRYAVLNQCNYVVLDEADRMIDMGFEPQVAGVLDAMPssnlkpeneeeeldeKKIYRTTYMFSATMPPGVERLA 529
Cdd:PRK01297 224 LLDFNQRGEVHLDMVEVMVLDEADRMLDMGFIPQVRQIIRQTP---------------RKEERQTLLFSATFTDDVMNLA 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 530 RKYLRNPVVVTIGTAGKTTDLISQHVIMMKESEKFFRLQKLLDELGEKTAIVFVNTKKNCDSIAKNLDKAGYRVTTLHGG 609
Cdd:PRK01297 289 KQWTTDPAIVEIEPENVASDTVEQHVYAVAGSDKYKLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGD 368
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1707017 610 KSQEQREISLEGFRAKRYNVLVATDVVGRGIDIPDVAHVINYDMPKHIEMYTHRIGRTGRAGKSGVATSFLTLHDT 685
Cdd:PRK01297 369 VPQHKRIKTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGEDDA 444
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
287-707 |
1.62e-83 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 274.36 E-value: 1.62e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 287 MTERDWRIFREDFNISYKGSRIPRPMRSWEESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAA 366
Cdd:PLN00206 95 LSSSQAELLRRKLEIHVKGEAVPPPILSFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTAS 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 367 FVLPMLAYISRLPPmSEENETEGPYAVVMAPTRELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIAT 446
Cdd:PLN00206 175 FLVPIISRCCTIRS-GHPSEQRNPLAMVLTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYRIQQGVELIVGT 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 447 PGRLIDCLERRYAVLNQCNYVVLDEADRMIDMGFEPQVAGVLDAMPSSNLkpeneeeeldekkiyrttYMFSATMPPGVE 526
Cdd:PLN00206 254 PGRLIDLLSKHDIELDNVSVLVLDEVDCMLERGFRDQVMQIFQALSQPQV------------------LLFSATVSPEVE 315
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 527 RLARKYLRNPVVVTIGTAGKTTDLISQHVIMMKESEKffrLQKLLDELGEKT-----AIVFVNTKKNCDSIAKNLDKA-G 600
Cdd:PLN00206 316 KFASSLAKDIILISIGNPNRPNKAVKQLAIWVETKQK---KQKLFDILKSKQhfkppAVVFVSSRLGADLLANAITVVtG 392
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 601 YRVTTLHGGKSQEQREISLEGFRAKRYNVLVATDVVGRGIDIPDVAHVINYDMPKHIEMYTHRIGRTGRAGKSGVATSFL 680
Cdd:PLN00206 393 LKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFV 472
|
410 420
....*....|....*....|....*..
gi 1707017 681 TLHDTEVFYDLKQMLVQSNSAVPPELA 707
Cdd:PLN00206 473 NEEDRNLFPELVALLKSSGAAIPRELA 499
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
320-679 |
2.94e-83 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 270.30 E-value: 2.94e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 320 LTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFvlpMLAYISRL--PPMSEENETEGPYAVVMAP 397
Cdd:PRK04837 15 LHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAF---LTATFHYLlsHPAPEDRKVNQPRALIMAP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 398 TRELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEADRMID 477
Cdd:PRK04837 92 TRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEADRMFD 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 478 MGFEPQVAGVLDAMPSSNlkpeneeeeldekkiYRTTYMFSATMPPGVERLARKYLRNPVVVTIGTAGKTTDLISQHVIM 557
Cdd:PRK04837 172 LGFIKDIRWLFRRMPPAN---------------QRLNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRIKEELFY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 558 MKESEKFFRLQKLLDELGEKTAIVFVNTKKNCDSIAKNLDKAGYRVTTLHGGKSQEQREISLEGFRAKRYNVLVATDVVG 637
Cdd:PRK04837 237 PSNEEKMRLLQTLIEEEWPDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAA 316
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1707017 638 RGIDIPDVAHVINYDMPKHIEMYTHRIGRTGRAGKSGVATSF 679
Cdd:PRK04837 317 RGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISL 358
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
314-695 |
1.78e-80 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 264.36 E-value: 1.78e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 314 SWEESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRLPPMSEENEtegPY-A 392
Cdd:PRK10590 2 SFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKGRR---PVrA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 393 VVMAPTRELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDcLERRYAV-LNQCNYVVLDE 471
Cdd:PRK10590 79 LILTPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLD-LEHQNAVkLDQVEILVLDE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 472 ADRMIDMGFEPQVAGVLDAMPSSnlkpeneeeeldekkiyRTTYMFSATMPPGVERLARKYLRNPVVVTIGTAGKTTDLI 551
Cdd:PRK10590 158 ADRMLDMGFIHDIRRVLAKLPAK-----------------RQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQV 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 552 SQHVIMMKESEKFFRLQKLLDELGEKTAIVFVNTKKNCDSIAKNLDKAGYRVTTLHGGKSQEQREISLEGFRAKRYNVLV 631
Cdd:PRK10590 221 TQHVHFVDKKRKRELLSQMIGKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLV 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1707017 632 ATDVVGRGIDIPDVAHVINYDMPKHIEMYTHRIGRTGRAGKSGVATSFLTLHDTEVFYDLKQML 695
Cdd:PRK10590 301 ATDIAARGLDIEELPHVVNYELPNVPEDYVHRIGRTGRAAATGEALSLVCVDEHKLLRDIEKLL 364
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
314-545 |
9.60e-80 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 253.95 E-value: 9.60e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 314 SWEESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRLPPMSEEN--ETEGPY 391
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEDGPPSVGRgrRKAYPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 392 AVVMAPTRELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDE 471
Cdd:cd17967 81 ALILAPTRELAIQIYEEARKFSYRSGVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGRISLSSIKFLVLDE 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1707017 472 ADRMIDMGFEPQVAGVLDA--MPSsnlkpeneeeeldekKIYRTTYMFSATMPPGVERLARKYLRNPVVVTIGTAG 545
Cdd:cd17967 161 ADRMLDMGFEPQIRKIVEHpdMPP---------------KGERQTLMFSATFPREIQRLAADFLKNYIFLTVGRVG 221
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
315-684 |
1.18e-79 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 261.42 E-value: 1.18e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 315 WEESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRLPpmseeNETEGPYAV- 393
Cdd:PRK11192 3 FSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDFP-----RRKSGPPRIl 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 394 VMAPTRELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQG--LKITQgcEIVIATPGRLIDCLERRYAVLNQCNYVVLDE 471
Cdd:PRK11192 78 ILTPTRELAMQVADQARELAKHTHLDIATITGGVAYMNHAevFSENQ--DIVVATPGRLLQYIKEENFDCRAVETLILDE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 472 ADRMIDMGFEPQVagvldampssnlkpeneeeeldeKKI------YRTTYMFSATMP-PGVERLARKYLRNPVVVTIGTA 544
Cdd:PRK11192 156 ADRMLDMGFAQDI-----------------------ETIaaetrwRKQTLLFSATLEgDAVQDFAERLLNDPVEVEAEPS 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 545 GKTTDLISQHVIMMKESE-KFFRLQKLLDELGEKTAIVFVNTKKNCDSIAKNLDKAGYRVTTLHGGKSQEQREISLEGFR 623
Cdd:PRK11192 213 RRERKKIHQWYYRADDLEhKTALLCHLLKQPEVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLT 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1707017 624 AKRYNVLVATDVVGRGIDIPDVAHVINYDMPKHIEMYTHRIGRTGRAGKSGVATSFLTLHD 684
Cdd:PRK11192 293 DGRVNVLVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISLVEAHD 353
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
304-540 |
5.24e-79 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 252.30 E-value: 5.24e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 304 KGSRIPRPMRSWEESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRLPPMSE 383
Cdd:cd17953 3 RGKDCPKPIQKWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKDQRPVKP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 384 EnetEGPYAVVMAPTRELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCL---ERRYAV 460
Cdd:cd17953 83 G---EGPIGLIMAPTRELALQIYVECKKFSKALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILtanNGRVTN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 461 LNQCNYVVLDEADRMIDMGFEPQVAGVLDampssNLKPEneeeeldekkiyRTTYMFSATMPPGVERLARKYLRNPVVVT 540
Cdd:cd17953 160 LRRVTYVVLDEADRMFDMGFEPQIMKIVN-----NIRPD------------RQTVLFSATFPRKVEALARKVLHKPIEIT 222
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
320-692 |
4.30e-75 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 253.33 E-value: 4.30e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 320 LTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRLPPMSEENeTEGPYAVVMAPTR 399
Cdd:PRK04537 16 LHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPALADRK-PEDPRALILAPTR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 400 ELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAV-LNQCNYVVLDEADRMIDM 478
Cdd:PRK04537 95 ELAIQIHKDAVKFGADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVVsLHACEICVLDEADRMFDL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 479 GFEPQVAGVLDAMPssnlkpeneeeeldeKKIYRTTYMFSATMPPGVERLARKYLRNPVVVTIGTAGKTTDLISQHVIMM 558
Cdd:PRK04537 175 GFIKDIRFLLRRMP---------------ERGTRQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQRIYFP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 559 KESEKFFRLQKLLDELGEKTAIVFVNTKKNCDSIAKNLDKAGYRVTTLHGGKSQEQREISLEGFRAKRYNVLVATDVVGR 638
Cdd:PRK04537 240 ADEEKQTLLLGLLSRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAAR 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 639 GIDIPDVAHVINYDMPKHIEMYTHRIGRTGRAGKSGVATSF------LTLHDTEVFYDLK 692
Cdd:PRK04537 320 GLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISFaceryaMSLPDIEAYIEQK 379
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
320-680 |
5.52e-74 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 251.69 E-value: 5.52e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 320 LTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYIsrlppmseENETEGPYAVVMAPTR 399
Cdd:PRK11634 13 LKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNL--------DPELKAPQILVLAPTR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 400 ELAQQIEEETVKFA-HYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEADRMIDM 478
Cdd:PRK11634 85 ELAVQVAEAMTDFSkHMRGVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDEADEMLRM 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 479 GFEPQVAGVLDAMPSSNlkpeneeeeldekkiyrTTYMFSATMPPGVERLARKYLRNPVVVTIGTAGKTTDLISQHVIMM 558
Cdd:PRK11634 165 GFIEDVETIMAQIPEGH-----------------QTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYWTV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 559 KESEKFFRLQKLLDELGEKTAIVFVNTKKNCDSIAKNLDKAGYRVTTLHGGKSQEQREISLEGFRAKRYNVLVATDVVGR 638
Cdd:PRK11634 228 WGMRKNEALVRFLEAEDFDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAAR 307
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1707017 639 GIDIPDVAHVINYDMPKHIEMYTHRIGRTGRAGKSGVATSFL 680
Cdd:PRK11634 308 GLDVERISLVVNYDIPMDSESYVHRIGRTGRAGRAGRALLFV 349
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
314-707 |
2.97e-71 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 237.80 E-value: 2.97e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 314 SWEESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYIsrlppmseENETEGPYAV 393
Cdd:PTZ00424 29 SFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLI--------DYDLNACQAL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 394 VMAPTRELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEAD 473
Cdd:PTZ00424 101 ILAPTRELAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEAD 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 474 RMIDMGFEPQVAGVLDAMPSSnlkpeneeeeldekkiyRTTYMFSATMPPGVERLARKYLRNPVVVTIGTAGKTTDLISQ 553
Cdd:PTZ00424 181 EMLSRGFKGQIYDVFKKLPPD-----------------VQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQ 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 554 HVIMM-KESEKFFRLQKLLDELGEKTAIVFVNTKKNCDSIAKNLDKAGYRVTTLHGGKSQEQREISLEGFRAKRYNVLVA 632
Cdd:PTZ00424 244 FYVAVeKEEWKFDTLCDLYETLTITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLIT 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1707017 633 TDVVGRGIDIPDVAHVINYDMPKHIEMYTHRIGRTGRAGKSGVATSFLTLHDTEVFYDLKQMLVQSNSAVPPELA 707
Cdd:PTZ00424 324 TDLLARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIERHYNTQIEEMPMEVA 398
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
305-545 |
3.38e-69 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 227.54 E-value: 3.38e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 305 GSRIPRPMRSWEESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAY-ISRLPPMSE 383
Cdd:cd18052 35 GRNPPPAILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGmMKEGLTASS 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 384 ENETEGPYAVVMAPTRELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQ 463
Cdd:cd18052 115 FSEVQEPQALIVAPTRELANQIFLEARKFSYGTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGKISLSK 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 464 CNYVVLDEADRMIDMGFEPQVAGVLDA--MPSsnlkpeneeeeldekKIYRTTYMFSATMPPGVERLARKYLR-NPVVVT 540
Cdd:cd18052 195 LKYLILDEADRMLDMGFGPEIRKLVSEpgMPS---------------KEDRQTLMFSATFPEEIQRLAAEFLKeDYLFLT 259
|
....*
gi 1707017 541 IGTAG 545
Cdd:cd18052 260 VGRVG 264
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
324-540 |
2.41e-68 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 223.06 E-value: 2.41e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 324 LLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRLPPMSEEnetEGPYAVVMAPTRELAQ 403
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQRELEKG---EGPIAVIVAPTRELAQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 404 QIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEADRMIDMGFEPQ 483
Cdd:cd17952 78 QIYLEAKKFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFDMGFEYQ 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1707017 484 VAGVLDampssNLKPEneeeeldekkiyRTTYMFSATMPPGVERLARKYLRNPVVVT 540
Cdd:cd17952 158 VRSIVG-----HVRPD------------RQTLLFSATFKKKIEQLARDILSDPIRVV 197
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
314-539 |
2.58e-68 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 222.96 E-value: 2.58e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 314 SWEESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPML-AYISRLPPMseenetegpYA 392
Cdd:cd17954 1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILqALLENPQRF---------FA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 393 VVMAPTRELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAV-LNQCNYVVLDE 471
Cdd:cd17954 72 LVLAPTRELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENTKGFsLKSLKFLVMDE 151
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1707017 472 ADRMIDMGFEPQVAGVLDAMPSSnlkpeneeeeldekkiyRTTYMFSATMPPGVERLARKYLRNPVVV 539
Cdd:cd17954 152 ADRLLNMDFEPEIDKILKVIPRE-----------------RTTYLFSATMTTKVAKLQRASLKNPVKI 202
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
324-540 |
3.62e-67 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 219.93 E-value: 3.62e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 324 LLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRLPPMSEeneTEGPYAVVMAPTRELAQ 403
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQPPLER---GDGPIVLVLAPTRELAQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 404 QIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEADRMIDMGFEPQ 483
Cdd:cd17966 78 QIQQEANKFGGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRMLDMGFEPQ 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1707017 484 VAGVLDampssNLKPEneeeeldekkiyRTTYMFSATMPPGVERLARKYLRNPVVVT 540
Cdd:cd17966 158 IRKIVD-----QIRPD------------RQTLMWSATWPKEVRRLAEDFLKDYIQVN 197
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
297-545 |
8.57e-63 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 210.28 E-value: 8.57e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 297 EDFNISYKGSRIPRPMRSWEESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYI- 375
Cdd:cd18051 5 EDIPVEATGENCPPHIETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIy 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 376 SRLPPMSEENETEG-------PYAVVMAPTRELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPG 448
Cdd:cd18051 85 EQGPGESLPSESGYygrrkqyPLALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGQQMRDLERGCHLLVATPG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 449 RLIDCLERRYAVLNQCNYVVLDEADRMIDMGFEPQVAGVL--DAMPSSNLkpeneeeeldekkiyRTTYMFSATMPPGVE 526
Cdd:cd18051 165 RLVDMLERGKIGLDYCKYLVLDEADRMLDMGFEPQIRRIVeqDTMPPTGE---------------RQTLMFSATFPKEIQ 229
|
250
....*....|....*....
gi 1707017 527 RLARKYLRNPVVVTIGTAG 545
Cdd:cd18051 230 MLARDFLDNYIFLAVGRVG 248
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
324-542 |
3.60e-62 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 206.67 E-value: 3.60e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 324 LLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRLppmseeNETEGPYAVVMAPTRELAQ 403
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGKP------RKKKGLRALILAPTRELAS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 404 QIEEETVKFAHYLGFRVTSIVGGQS-IEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEADRMIDMGFEP 482
Cdd:cd17957 75 QIYRELLKLSKGTGLRIVLLSKSLEaKAKDGPKSITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLFEPGFRE 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 483 QVAGVLDAMPSSNLkpeneeeeldekkiyrTTYMFSATMPPGVERLARKYLRNPVVVTIG 542
Cdd:cd17957 155 QTDEILAACTNPNL----------------QRSLFSATIPSEVEELARSVMKDPIRIIVG 198
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
551-680 |
4.01e-60 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 198.50 E-value: 4.01e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 551 ISQHVIMMKESEKFFRL-QKLLDELGEKTAIVFVNTKKNCDSIAKNLDKAGYRVTTLHGGKSQEQREISLEGFRAKRYNV 629
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLlLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1707017 630 LVATDVVGRGIDIPDVAHVINYDMPKHIEMYTHRIGRTGRAGKSGVATSFL 680
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
314-539 |
1.95e-56 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 191.36 E-value: 1.95e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 314 SWEESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMlayISRLppmSEENETEGPYAV 393
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPM---IEKL---KAHSPTVGARAL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 394 VMAPTRELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEAD 473
Cdd:cd17959 76 ILSPTRELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVEYVVFDEAD 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1707017 474 RMIDMGFEPQVAGVLDAMPSSnlkpeneeeeldekkiyRTTYMFSATMPPGVERLARKYLRNPVVV 539
Cdd:cd17959 156 RLFEMGFAEQLHEILSRLPEN-----------------RQTLLFSATLPKLLVEFAKAGLNEPVLI 204
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
337-528 |
4.89e-56 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 188.61 E-value: 4.89e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 337 SPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRLPPmseeneteGPYAVVMAPTRELAQQIEEETVKFAHYL 416
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDN--------GPQALVLAPTRELAEQIYEELKKLGKGL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 417 GFRVTSIVGGQSIEEQGLKItQGCEIVIATPGRLIDCLERRyAVLNQCNYVVLDEADRMIDMGFEPQVAGVLDAMPSSnl 496
Cdd:pfam00270 73 GLKVASLLGGDSRKEQLEKL-KGPDILVGTPGRLLDLLQER-KLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKK-- 148
|
170 180 190
....*....|....*....|....*....|..
gi 1707017 497 kpeneeeeldekkiyRTTYMFSATMPPGVERL 528
Cdd:pfam00270 149 ---------------RQILLLSATLPRNLEDL 165
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
324-540 |
7.58e-56 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 189.60 E-value: 7.58e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 324 LLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRLPPMSEENEteGPYAVVMAPTRELAQ 403
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPIPREQRN--GPGVLVLTPTRELAL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 404 QIEEETVKFAhYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEADRMIDMGFEPQ 483
Cdd:cd17958 79 QIEAECSKYS-YKGLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMGFEPQ 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1707017 484 VAGVL-DAMPSsnlkpeneeeeldekkiyRTTYMFSATMPPGVERLARKYLRNPVVVT 540
Cdd:cd17958 158 IRKILlDIRPD------------------RQTIMTSATWPDGVRRLAQSYLKDPMIVY 197
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
295-542 |
3.91e-55 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 189.06 E-value: 3.91e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 295 FREDFNISYKGSRIPRPMRSWEESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAY 374
Cdd:cd18049 6 YRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVH 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 375 ISRLPPMSEeneTEGPYAVVMAPTRELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCL 454
Cdd:cd18049 86 INHQPFLER---GDGPICLVLAPTRELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 455 ERRYAVLNQCNYVVLDEADRMIDMGFEPQVAGVLDampssNLKPEneeeeldekkiyRTTYMFSATMPPGVERLARKYLR 534
Cdd:cd18049 163 EAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVD-----QIRPD------------RQTLMWSATWPKEVRQLAEDFLK 225
|
....*...
gi 1707017 535 NPVVVTIG 542
Cdd:cd18049 226 DYIHINIG 233
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
316-538 |
2.87e-54 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 185.51 E-value: 2.87e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 316 EESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRLPpmseenetEGPYAVVM 395
Cdd:cd17955 2 EDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRLSEDP--------YGIFALVL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 396 APTRELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLE---RRYAVLNQCNYVVLDEA 472
Cdd:cd17955 74 TPTRELAYQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRssdDTTKVLSRVKFLVLDEA 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1707017 473 DRMIDMGFEPQVAGVLDAMPSSnlkpeneeeeldekkiyRTTYMFSATMPPGVERLARKYLRNPVV 538
Cdd:cd17955 154 DRLLTGSFEDDLATILSALPPK-----------------RQTLLFSATLTDALKALKELFGNKPFF 202
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
324-540 |
3.03e-53 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 182.39 E-value: 3.03e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 324 LLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRlppMSEENETEGPYAVVMAPTRELAQ 403
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLK---RKANLKKGQVGALIISPTRELAT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 404 QIEEETVKFAHYLGFRVTS--IVGGQSIEEQGLKIT-QGCEIVIATPGRLIDCLERRYAVLN--QCNYVVLDEADRMIDM 478
Cdd:cd17960 78 QIYEVLQSFLEHHLPKLKCqlLIGGTNVEEDVKKFKrNGPNILVGTPGRLEELLSRKADKVKvkSLEVLVLDEADRLLDL 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1707017 479 GFEPQVAGVLDAMPssnlkpeneeeeldeKKiyRTTYMFSATMPPGVERLARKYLRNPVVVT 540
Cdd:cd17960 158 GFEADLNRILSKLP---------------KQ--RRTGLFSATQTDAVEELIKAGLRNPVRVV 202
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
324-539 |
5.25e-53 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 181.68 E-value: 5.25e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 324 LLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRLPPMseeneteGPY--AVVMAPTREL 401
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYRPKK-------KAAtrVLVLVPTREL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 402 AQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAV-LNQCNYVVLDEADRMIDMGF 480
Cdd:cd17947 74 AMQCFSVLQQLAQFTDITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSPSFdLDSIEILVLDEADRMLEEGF 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1707017 481 EPQVAGVLDAMPSSnlkpeneeeeldekkiyRTTYMFSATMPPGVERLARKYLRNPVVV 539
Cdd:cd17947 154 ADELKEILRLCPRT-----------------RQTMLFSATMTDEVKDLAKLSLNKPVRV 195
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
324-539 |
7.65e-53 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 181.77 E-value: 7.65e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 324 LLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYI----SRLPPMseenETEGPYAVVMAPTR 399
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFAleqeKKLPFI----KGEGPYGLIVCPSR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 400 ELAQQIEEETVKFAHYL------GFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEAD 473
Cdd:cd17951 77 ELARQTHEVIEYYCKALqeggypQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEAD 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1707017 474 RMIDMGFEPQVAGVLDAMPSSnlkpeneeeeldekkiyRTTYMFSATMPPGVERLARKYLRNPVVV 539
Cdd:cd17951 157 RMIDMGFEEDIRTIFSYFKGQ-----------------RQTLLFSATMPKKIQNFAKSALVKPVTV 205
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
320-534 |
2.67e-52 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 180.47 E-value: 2.67e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 320 LTSELLKAVERAGYKKPSPIQMAAIPLGLQQR-DVIGIAETGSGKTAAFVLPMLAYISRLPPMSEENETEgpyAVVMAPT 398
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPILSTGdDVLARAKTGTGKTLAFLLPAIQSLLNTKPAGRRSGVS---ALIISPT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 399 RELAQQIEEETVKFAHYL-GFRVTSIVGGQSIEEQGLKI-TQGCEIVIATPGRLIDCLERRYA--VLNQCNYVVLDEADR 474
Cdd:cd17964 78 RELALQIAAEAKKLLQGLrKLRVQSAVGGTSRRAELNRLrRGRPDILVATPGRLIDHLENPGVakAFTDLDYLVLDEADR 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 475 MIDMGFEPQVAGVLDAMPSSNLKPeneeeeldekkiyRTTYMFSATMPPGVERLARKYLR 534
Cdd:cd17964 158 LLDMGFRPDLEQILRHLPEKNADP-------------RQTLLFSATVPDEVQQIARLTLK 204
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
287-542 |
3.45e-52 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 182.13 E-value: 3.45e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 287 MTERDWRIFREDFNISYKGSRIPRPMRSWEESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAA 366
Cdd:cd18050 36 MTQYDVEELRRKKEITIRGVGCPKPVFAFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 367 FVLPMLAYISRLPPMSEeneTEGPYAVVMAPTRELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIAT 446
Cdd:cd18050 116 YLLPAIVHINHQPYLER---GDGPICLVLAPTRELAQQVQQVADDYGKSSRLKSTCIYGGAPKGPQIRDLERGVEICIAT 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 447 PGRLIDCLERRYAVLNQCNYVVLDEADRMIDMGFEPQVAGVLDampssNLKPEneeeeldekkiyRTTYMFSATMPPGVE 526
Cdd:cd18050 193 PGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVD-----QIRPD------------RQTLMWSATWPKEVR 255
|
250
....*....|....*.
gi 1707017 527 RLARKYLRNPVVVTIG 542
Cdd:cd18050 256 QLAEDFLRDYVQINIG 271
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
328-540 |
7.64e-51 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 176.62 E-value: 7.64e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 328 VERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRLPPMSeeNETEGPYAVVMAPTRELAQQIEE 407
Cdd:cd17949 6 KSKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRV--DRSDGTLALVLVPTRELALQIYE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 408 ET---VKFAHYLgfRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYA-VLNQCNYVVLDEADRMIDMGFEPQ 483
Cdd:cd17949 84 VLeklLKPFHWI--VPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNTQSfDVSNLRWLVLDEADRLLDMGFEKD 161
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1707017 484 VAGVLDAMPSSNLKpeneEEELDEKKIYRTTYMFSATMPPGVERLARKYLRNPVVVT 540
Cdd:cd17949 162 ITKILELLDDKRSK----AGGEKSKPSRRQTVLVSATLTDGVKRLAGLSLKDPVYID 214
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
324-521 |
1.58e-49 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 173.58 E-value: 1.58e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 324 LLKAVERAGYKKPSPIQMAAIPLGLQQR-DVIGIAETGSGKTAAFVLPMLAYI-SRLPPMSEENETEGPYAVVMAPTREL 401
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAAIRDGkDVIGAAETGSGKTLAFGIPILERLlSQKSSNGVGGKQKPLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 402 AQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQ---CNYVVLDEADRMIDM 478
Cdd:cd17946 81 AVQVKDHLKAIAKYTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGNEHLANlksLRFLVLDEADRMLEK 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1707017 479 G-FEpQVAGVLDAMPSSNlkpeneeeelDEKKIYRTTYMFSATM 521
Cdd:cd17946 161 GhFA-ELEKILELLNKDR----------AGKKRKRQTFVFSATL 193
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
328-542 |
2.67e-49 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 171.91 E-value: 2.67e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 328 VERAGYKKPSPIQMAAIPLGLQ-QRDVIGIAETGSGKTAAFVLPMLAYISRLPpmseeneteGPYAVVMAPTRELAQQIE 406
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSgLRDVILAAPTGSGKTLAALLPALEALKRGK---------GGRVLVLVPTRELAEQWA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 407 EETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGC-EIVIATPGRLIDCLERRYAVLNQCNYVVLDEADRMIDMGFEPQVA 485
Cdd:smart00487 72 EELKKLGPSLGLKVVGLYGGDSKREQLRKLESGKtDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLE 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1707017 486 GVLDAMPSSnlkpeneeeeldekkiyRTTYMFSATMPPGVERLARKYLRNPVVVTIG 542
Cdd:smart00487 152 KLLKLLPKN-----------------VQLLLLSATPPEEIENLLELFLNDPVFIDVG 191
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
315-539 |
1.52e-48 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 169.79 E-value: 1.52e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 315 WEESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISrlppmSEENETEgpyAVV 394
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKID-----PKKDVIQ---ALI 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 395 MAPTRELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEADR 474
Cdd:cd17940 73 LVPTRELALQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEADK 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1707017 475 MIDMGFEPQVAGVLDAMPSSnlkpeneeeeldekkiyRTTYMFSATMPPGVERLARKYLRNPVVV 539
Cdd:cd17940 153 LLSQDFQPIIEKILNFLPKE-----------------RQILLFSATFPLTVKNFMDRHMHNPYEI 200
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
325-539 |
1.14e-47 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 167.08 E-value: 1.14e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 325 LKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRLppmsEENETEGPYAVVMAPTRELAQQ 404
Cdd:cd17941 2 LKGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRE----RWTPEDGLGALIISPTRELAMQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 405 IEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQgCEIVIATPGRLIDCL-ERRYAVLNQCNYVVLDEADRMIDMGFEPQ 483
Cdd:cd17941 78 IFEVLRKVGKYHSFSAGLIIGGKDVKEEKERINR-MNILVCTPGRLLQHMdETPGFDTSNLQMLVLDEADRILDMGFKET 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1707017 484 VAGVLDAMPSSnlkpeneeeeldekkiyRTTYMFSATMPPGVERLARKYLRNPVVV 539
Cdd:cd17941 157 LDAIVENLPKS-----------------RQTLLFSATQTKSVKDLARLSLKNPEYI 195
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
320-541 |
1.87e-46 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 163.91 E-value: 1.87e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 320 LTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYIsrLPPMSEENETEGPYAVVMAPTR 399
Cdd:cd17961 1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKI--LKAKAESGEEQGTRALILVPTR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 400 ELAQQIEEETVKFAHYLG--FRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLER-RYAVLNQCNYVVLDEADRMI 476
Cdd:cd17961 79 ELAQQVSKVLEQLTAYCRkdVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESgSLLLLSTLKYLVIDEADLVL 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1707017 477 DMGFEPQVAGVLDAMPssnlkpeneeeeldekKIYRTTYMfSATMPPGVERLARKYLRNPVVVTI 541
Cdd:cd17961 159 SYGYEEDLKSLLSYLP----------------KNYQTFLM-SATLSEDVEALKKLVLHNPAILKL 206
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
324-540 |
7.56e-46 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 161.95 E-value: 7.56e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 324 LLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLayisrlppMSEENETEGPYAVVMAPTRELAQ 403
Cdd:cd17962 1 LSSNLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVI--------IRCLTEHRNPSALILTPTRELAV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 404 QIEEETVKFAH-YLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEADRMIDMGFEP 482
Cdd:cd17962 73 QIEDQAKELMKgLPPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMGFQQ 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1707017 483 QVAGVLDAMPSSNlkpeneeeeldekkiyrTTYMFSATMPPGVERLARKYLRNPVVVT 540
Cdd:cd17962 153 QVLDILENISHDH-----------------QTILVSATIPRGIEQLAGQLLQNPVRIT 193
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
320-537 |
4.34e-43 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 154.40 E-value: 4.34e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 320 LTSELLKAVERAGYKKPSPIQMAAI-PLgLQQRDVIGIAETGSGKTAAFVLPMLAYISrlppmSEENETEgpyAVVMAPT 398
Cdd:cd17939 4 LSEDLLRGIYAYGFEKPSAIQQRAIvPI-IKGRDVIAQAQSGTGKTATFSIGALQRID-----TTVRETQ---ALVLAPT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 399 RELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEADRMIDM 478
Cdd:cd17939 75 RELAQQIQKVVKALGDYMGVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEMLSR 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1707017 479 GFEPQVAGVLDAMPssnlkpeneeeeldeKKIyrTTYMFSATMPPGVERLARKYLRNPV 537
Cdd:cd17939 155 GFKDQIYDIFQFLP---------------PET--QVVLFSATMPHEVLEVTKKFMRDPV 196
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
320-540 |
2.34e-42 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 152.34 E-value: 2.34e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 320 LTSELLKAVERAGYKKPSPIQMAAIPLGLQQ--RDVIGIAETGSGKTAAFVLPMLAYISRLPPMseenetegPYAVVMAP 397
Cdd:cd17963 1 LKPELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRVDPTLKS--------PQALCLAP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 398 TRELAQQIEEETVKFAHYLGFRVTSIVGGqSIEEQGLKITQgcEIVIATPGRLIDCLERRYAVLNQCNYVVLDEADRMID 477
Cdd:cd17963 73 TRELARQIGEVVEKMGKFTGVKVALAVPG-NDVPRGKKITA--QIVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVMLD 149
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1707017 478 M-GFEPQVAGVLDAMPsSNLKpeneeeeldekkiyrtTYMFSATMPPGVERLARKYLRNPVVVT 540
Cdd:cd17963 150 TqGHGDQSIRIKRMLP-RNCQ----------------ILLFSATFPDSVRKFAEKIAPNANTIK 196
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
315-537 |
1.84e-40 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 147.21 E-value: 1.84e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 315 WEESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYIsrlppmseENETEGPYAVV 394
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQI--------DTSLKATQALV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 395 MAPTRELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEADR 474
Cdd:cd18046 73 LAPTRELAQQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADE 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1707017 475 MIDMGFEPQVAGVLDAMPSSNlkpeneeeeldekkiyrTTYMFSATMPPGVERLARKYLRNPV 537
Cdd:cd18046 153 MLSRGFKDQIYDIFQKLPPDT-----------------QVVLLSATMPNDVLEVTTKFMRDPI 198
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
316-539 |
2.25e-39 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 144.39 E-value: 2.25e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 316 EESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISrlppmseenetegpyAVVM 395
Cdd:cd17938 2 EELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIVV---------------ALIL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 396 APTRELAQQIEEETVKFAHYL---GFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEA 472
Cdd:cd17938 67 EPSRELAEQTYNCIENFKKYLdnpKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSVRFFVLDEA 146
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1707017 473 DRMIDMGFEPQVAGVLDAMPssnlkpeneEEELDEKKIyrTTYMFSATM-PPGVERLARKYLRNPVVV 539
Cdd:cd17938 147 DRLLSQGNLETINRIYNRIP---------KITSDGKRL--QVIVCSATLhSFEVKKLADKIMHFPTWV 203
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
324-539 |
5.31e-38 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 140.09 E-value: 5.31e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 324 LLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRlppmseenETEGPYAVVMAPTRELAQ 403
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDL--------ERRHPQVLILAPTREIAV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 404 QIEEETVKFAHYL-GFRVTSIVGGQSIEEQGLKItQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEADRMIDMGFEP 482
Cdd:cd17943 73 QIHDVFKKIGKKLeGLKCEVFIGGTPVKEDKKKL-KGCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLMEGSFQK 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1707017 483 QVAGVLDAMPSSnlkpeneeeeldekkiyRTTYMFSATMPPGVERLARKYLRNPVVV 539
Cdd:cd17943 152 DVNWIFSSLPKN-----------------KQVIAFSATYPKNLDNLLARYMRKPVLV 191
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
562-671 |
9.87e-36 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 130.41 E-value: 9.87e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 562 EKFFRLQKLLDELGEKTAIVFVNTKKNCDsiAKNL-DKAGYRVTTLHGGKSQEQREISLEGFRAKRYNVLVATDVVGRGI 640
Cdd:pfam00271 1 EKLEALLELLKKERGGKVLIFSQTKKTLE--AELLlEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 1707017 641 DIPDVAHVINYDMPKHIEMYTHRIGRTGRAG 671
Cdd:pfam00271 79 DLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
320-541 |
3.68e-34 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 129.77 E-value: 3.68e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 320 LTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRLPPMSEenetegpyAVVMAPTR 399
Cdd:cd17950 9 LKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVS--------VLVICHTR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 400 ELAQQIEEETVKFAHYL-GFRVTSIVGGQSI--EEQGLKiTQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEADRMI 476
Cdd:cd17950 81 ELAFQISNEYERFSKYMpNVKTAVFFGGVPIkkDIEVLK-NKCPHIVVGTPGRILALVREKKLKLSHVKHFVLDECDKML 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1707017 477 ---DMGFEPQvagvldampssnlkpeneeeeldekKIYRTT------YMFSATMPPGVERLARKYLRNPVVVTI 541
Cdd:cd17950 160 eqlDMRRDVQ-------------------------EIFRATphdkqvMMFSATLSKEIRPVCKKFMQDPLEIFV 208
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
315-539 |
5.08e-34 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 129.12 E-value: 5.08e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 315 WEESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYIsrlppmseENETEGPYAVV 394
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCL--------DIQVRETQALI 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 395 MAPTRELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEADR 474
Cdd:cd18045 73 LSPTRELAVQIQKVLLALGDYMNVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEADE 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1707017 475 MIDMGFEPQVAGVLDAMPSSNlkpeneeeeldekkiyrTTYMFSATMPPGVERLARKYLRNPVVV 539
Cdd:cd18045 153 MLNKGFKEQIYDVYRYLPPAT-----------------QVVLVSATLPQDILEMTNKFMTDPIRI 200
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
325-536 |
1.54e-32 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 124.78 E-value: 1.54e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 325 LKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRLPPMSEenetEGPYAVVMAPTRELAQQ 404
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLYKLKFKPR----NGTGVIIISPTRELALQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 405 IEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLE--RRYAVLN-QCnyVVLDEADRMIDMGFE 481
Cdd:cd17942 78 IYGVAKELLKYHSQTFGIVIGGANRKAEAEKLGKGVNILVATPGRLLDHLQntKGFLYKNlQC--LIIDEADRILEIGFE 155
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1707017 482 PQVAGVLDAMPSSnlkpeneeeeldekkiyRTTYMFSATMPPGVERLARKYLRNP 536
Cdd:cd17942 156 EEMRQIIKLLPKR-----------------RQTMLFSATQTRKVEDLARISLKKK 193
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
324-528 |
5.10e-31 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 121.32 E-value: 5.10e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 324 LLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRlPPMSEENETEGPYAVVMAPTRELAQ 403
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLR-YKLLAEGPFNAPRGLVITPSRELAE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 404 QIEEETVKFAHYLGFRVTSIVGGQSIeEQGLKITQG-CEIVIATPGRLIDCLERRYAVLNQCNYVVLDEADRMIDMGFEP 482
Cdd:cd17948 80 QIGSVAQSLTEGLGLKVKVITGGRTK-RQIRNPHFEeVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLLDDSFNE 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1707017 483 QVAGVLDAMP-SSNLKPENEEEELDEKKIyrttyMFSATMPPGVERL 528
Cdd:cd17948 159 KLSHFLRRFPlASRRSENTDGLDPGTQLV-----LVSATMPSGVGEV 200
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
590-671 |
1.21e-29 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 112.31 E-value: 1.21e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 590 DSIAKNLDKAGYRVTTLHGGKSQEQREISLEGFRAKRYNVLVATDVVGRGIDIPDVAHVINYDMPKHIEMYTHRIGRTGR 669
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 1707017 670 AG 671
Cdd:smart00490 81 AG 82
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
324-540 |
8.71e-29 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 115.04 E-value: 8.71e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 324 LLKAVERAGYKKPSPIQMAAIPLGLQQ---------RDVIGIAETGSGKTAAFVLPMLAYIS-----RLppmseeneteg 389
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSskstppyrpGDLCVSAPTGSGKTLAYVLPIVQALSkrvvpRL----------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 390 pYAVVMAPTRELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCE--------IVIATPGRLIDCLER-RYAV 460
Cdd:cd17956 70 -RALIVVPTKELVQQVYKVFESLCKGTGLKVVSLSGQKSFKKEQKLLLVDTSgrylsrvdILVATPGRLVDHLNStPGFT 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 461 LNQCNYVVLDEADRMIDMGFE---PQVAGVLDAMPSSNLKPENEEEELDEKKIYRTTYMFSATMPPGVERLARKYLRNPV 537
Cdd:cd17956 149 LKHLRFLVIDEADRLLNQSFQdwlETVMKALGRPTAPDLGSFGDANLLERSVRPLQKLLFSATLTRDPEKLSSLKLHRPR 228
|
...
gi 1707017 538 VVT 540
Cdd:cd17956 229 LFT 231
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
338-534 |
2.23e-25 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 104.16 E-value: 2.23e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 338 PIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMlayISRLPPMSEE-NETEGPYAVVMAPTRELAQQIEEETVKFAHYL 416
Cdd:cd17944 15 PIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPL---IEKLQEDQQPrKRGRAPKVLVLAPTRELANQVTKDFKDITRKL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 417 gfRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEADRMIDMGFEPQVAGVLDAM--PSS 494
Cdd:cd17944 92 --SVACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMGFAEQVEEILSVSykKDS 169
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1707017 495 NLKPEneeeeldekkiyrtTYMFSATMPPGVERLARKYLR 534
Cdd:cd17944 170 EDNPQ--------------TLLFSATCPDWVYNVAKKYMK 195
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
332-540 |
3.21e-24 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 102.45 E-value: 3.21e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 332 GYKKPSPIQMAAIPLGLQQR---------------DVIGIA-ETGSGKTAAFVLPMLAYISRL---PPMSEENETEG--- 389
Cdd:cd17965 27 EEIKPSPIQTLAIKKLLKTLmrkvtkqtsneepklEVFLLAaETGSGKTLAYLAPLLDYLKRQeqePFEEAEEEYESakd 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 390 ---PYAVVMAPTRELAQQIEEETVKFAHYLGFRVTSIVG--GQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQC 464
Cdd:cd17965 107 tgrPRSVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSgfGPSYQRLQLAFKGRIDILVTTPGKLASLAKSRPKILSRV 186
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1707017 465 NYVVLDEADRMIDMGFEPQVAGVLDAMPSSNlkpeneeeeldeKKIyrttyMFSATMPPGVERLARKYLRNPVVVT 540
Cdd:cd17965 187 THLVVDEADTLFDRSFLQDTTSIIKRAPKLK------------HLI-----LCSATIPKEFDKTLRKLFPDVVRIA 245
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
312-541 |
3.71e-24 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 101.64 E-value: 3.71e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 312 MRSWEESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQ--RDVIGIAETGSGKTAAFVLPMLAYISRLPPMseeneteg 389
Cdd:cd18048 17 VKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDALKLY-------- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 390 PYAVVMAPTRELAQQ---IEEETVKFAhyLGFRVTSIVGGQSIeEQGLKITQgcEIVIATPGRLID-CLERRYAVLNQCN 465
Cdd:cd18048 89 PQCLCLSPTFELALQtgkVVEEMGKFC--VGIQVIYAIRGNRP-GKGTDIEA--QIVIGTPGTVLDwCFKLRLIDVTNIS 163
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1707017 466 YVVLDEADRMIDM-GFEPQVAGVLDAMPSSNlkpeneeeeldekkiyrTTYMFSATMPPGVERLARKYLRNPVVVTI 541
Cdd:cd18048 164 VFVLDEADVMINVqGHSDHSVRVKRSMPKEC-----------------QMLLFSATFEDSVWAFAERIVPDPNIIKL 223
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
554-713 |
1.66e-22 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 101.76 E-value: 1.66e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 554 HVIMMKESEKFFRLQKLLDELGEKTAIVFVNTKKNCDSIAKNLDKAGYRVTTLHGGKSQEQREISLEGFRAKRYNVLVAT 633
Cdd:COG0514 208 EVVPKPPDDKLAQLLDFLKEHPGGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVAT 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 634 DVVGRGIDIPDVAHVINYDMPKHIEMYTHRIGRTGRAGKSGVATSFLTLHDTEVfydLKQMLvqSNSAVPPELARHEASR 713
Cdd:COG0514 288 IAFGMGIDKPDVRFVIHYDLPKSIEAYYQEIGRAGRDGLPAEALLLYGPEDVAI---QRFFI--EQSPPDEERKRVERAK 362
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
253-649 |
2.26e-20 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 95.48 E-value: 2.26e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 253 EEAAAQRVREEAADTYDSFDMRVDRHWSDKRLEEMTERDWRIFREDFNISYKGSRIPRPMRSweeskltSELLKAVERAG 332
Cdd:COG1061 3 LRGIAERGADKLRSSLLLLDLERLELSLLRNLVEARRLAIKEGTREDGRRLPEEDTERELAE-------AEALEAGDEAS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 333 YKKPS--PIQMAAI-----PLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRLPpmseenetegpyAVVMAPTRELAQQI 405
Cdd:COG1061 76 GTSFElrPYQQEALeallaALERGGGRGLVVAPTGTGKTVLALALAAELLRGKR------------VLVLVPRRELLEQW 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 406 EEEtvkFAHYLGfrvtsivggqSIEEQGLKITQGCEIVIATPGRLIDCLERRYaVLNQCNYVVLDEADRMIDMGFEpqva 485
Cdd:COG1061 144 AEE---LRRFLG----------DPLAGGGKKDSDAPITVATYQSLARRAHLDE-LGDRFGLVIIDEAHHAGAPSYR---- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 486 GVLDAMPSSNL----------KPENEEEELDEKKIYRTTYmfsatmppgVERLARKYLRNPVVVTIGT----AGKTTDLI 551
Cdd:COG1061 206 RILEAFPAAYRlgltatpfrsDGREILLFLFDGIVYEYSL---------KEAIEDGYLAPPEYYGIRVdltdERAEYDAL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 552 SQHV---IMMKESEKFFRLQKLLDELGE-KTAIVFVNTKKNCDSIAKNLDKAGYRVTTLHGGKSQEQREISLEGFRAKRY 627
Cdd:COG1061 277 SERLreaLAADAERKDKILRELLREHPDdRKTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGEL 356
|
410 420
....*....|....*....|..
gi 1707017 628 NVLVATDVVGRGIDIPDVAHVI 649
Cdd:COG1061 357 RILVTVDVLNEGVDVPRLDVAI 378
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
313-539 |
2.13e-17 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 81.30 E-value: 2.13e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 313 RSWEESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQ--RDVIGIAETGSGKTAAFVLPMLAYISRLPPMSEenetegp 390
Cdd:cd18047 1 KSFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQ------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 391 yAVVMAPTRELAQQ---IEEETVKFahYLGFRVTSIVGGQSIeEQGLKITQgcEIVIATPGRLID-CLERRYAVLNQCNY 466
Cdd:cd18047 74 -CLCLSPTYELALQtgkVIEQMGKF--YPELKLAYAVRGNKL-ERGQKISE--QIVIGTPGTVLDwCSKLKFIDPKKIKV 147
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1707017 467 VVLDEADRMI-DMGFEPQVAGVLDAMPSSNlkpeneeeeldekkiyrTTYMFSATMPPGVERLARKYLRNPVVV 539
Cdd:cd18047 148 FVLDEADVMIaTQGHQDQSIRIQRMLPRNC-----------------QMLLFSATFEDSVWKFAQKVVPDPNVI 204
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
559-672 |
2.40e-17 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 78.79 E-value: 2.40e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 559 KESEKFFRLQKLLDELGEKTAIVFVNTKKNCDSIAKNLDKAGYRVTTLHGGKSQEQREISLEGFRAKRYNVLVATDVVGR 638
Cdd:cd18794 13 KKDEKLDLLKRIKVEHLGGSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGM 92
|
90 100 110
....*....|....*....|....*....|....
gi 1707017 639 GIDIPDVAHVINYDMPKHIEMYTHRIGRTGRAGK 672
Cdd:cd18794 93 GIDKPDVRFVIHYSLPKSMESYYQESGRAGRDGL 126
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
561-673 |
3.97e-15 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 73.01 E-value: 3.97e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 561 SEKFFRLQKLLDE----LGEKTAIVFVNTKKNCDSIAK-----NLDKAGYRVTTLHGGKS-----------QEQREIsLE 620
Cdd:cd18802 6 IPKLQKLIEILREyfpkTPDFRGIIFVERRATAVVLSRllkehPSTLAFIRCGFLIGRGNssqrkrslmtqRKQKET-LD 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1707017 621 GFRAKRYNVLVATDVVGRGIDIPDVAHVINYDMPKHIEMYTHRIGRtGRAGKS 673
Cdd:cd18802 85 KFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR-ARAPNS 136
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
560-672 |
6.77e-14 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 75.54 E-value: 6.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 560 ESEKFFRLQKLLDE-LGEKT---AIVFVNTKKNCDSIAKNLDKAGYRVTTLHG--------GKSQ-EQREIsLEGFRAKR 626
Cdd:COG1111 333 EHPKLSKLREILKEqLGTNPdsrIIVFTQYRDTAEMIVEFLSEPGIKAGRFVGqaskegdkGLTQkEQIEI-LERFRAGE 411
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1707017 627 YNVLVATDVVGRGIDIPDVAHVINYD-MPKHIEmYTHRIGRTGRAGK 672
Cdd:COG1111 412 FNVLVATSVAEEGLDIPEVDLVIFYEpVPSEIR-SIQRKGRTGRKRE 457
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
352-475 |
2.44e-13 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 67.81 E-value: 2.44e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 352 DVIGIAETGSGKTAAFVLPMLayisrlppmsEENETEGPYAVVMAPTRELAQQIEEEtVKFAHYLGFRVTSIVGGQSIEE 431
Cdd:cd00046 3 NVLITAPTGSGKTLAALLAAL----------LLLLKKGKKVLVLVPTKALALQTAER-LRELFGPGIRVAVLVGGSSAEE 71
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1707017 432 QGLKITQGCEIVIATPGRLIDCLERRYA-VLNQCNYVVLDEADRM 475
Cdd:cd00046 72 REKNKLGDADIIIATPDMLLNLLLREDRlFLKDLKLIIVDEAHAL 116
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
323-700 |
4.52e-13 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 72.24 E-value: 4.52e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 323 ELLKAVERAGYKKPSPIQMAAIPLGLQQRD-VIGIAETGSGKTAAFVLPMLAYISRlppmseeneteGPYAVVMAPTREL 401
Cdd:COG1204 10 KVIEFLKERGIEELYPPQAEALEAGLLEGKnLVVSAPTASGKTLIAELAILKALLN-----------GGKALYIVPLRAL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 402 AQQIEEETVKFAHYLGFRVTSIVGGqsIEEQGLKITQgCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEA--------- 472
Cdd:COG1204 79 ASEKYREFKRDFEELGIKVGVSTGD--YDSDDEWLGR-YDILVATPEKLDSLLRNGPSWLRDVDLVVVDEAhliddesrg 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 473 -------DRMIDMGFEPQVAGVldampssnlkpeneeeeldekkiyrttymfSATMpPGVERLARkYLRNPVVvtiGTAG 545
Cdd:COG1204 156 ptlevllARLRRLNPEAQIVAL------------------------------SATI-GNAEEIAE-WLDAELV---KSDW 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 546 KTTDL----ISQHVIMMKESEKFFRLQKL---LDELGEKT-AIVFVNTKKNCDSIAKNLDKA------------------ 599
Cdd:COG1204 201 RPVPLnegvLYDGVLRFDDGSRRSKDPTLalaLDLLEEGGqVLVFVSSRRDAESLAKKLADElkrrltpeereeleelae 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 600 -----------GYRVTTL--------HGGKSQEQREISLEGFRAKRYNVLVATDVVGRGIDIPdVAHVI--------NYD 652
Cdd:COG1204 281 ellevseethtNEKLADClekgvafhHAGLPSELRRLVEDAFREGLIKVLVATPTLAAGVNLP-ARRVIirdtkrggMVP 359
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 1707017 653 MPkHIE---MythrIGRTGRAGKSGVATSFLTLHDTEVFYDLKQMLVQSNS 700
Cdd:COG1204 360 IP-VLEfkqM----AGRAGRPGYDPYGEAILVAKSSDEADELFERYILGEP 405
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
577-673 |
2.90e-12 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 64.98 E-value: 2.90e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 577 KTAIVFVNTKKNCDSIAKNL-DKAGYRVTTL-----HGGKSQEQREISLEGFRAKRYNVLVATDVVGRGIDIPDVAHVIN 650
Cdd:cd18796 39 KSTLVFTNTRSQAERLAQRLrELCPDRVPPDfialhHGSLSRELREEVEAALKRGDLKVVVATSSLELGIDIGDVDLVIQ 118
|
90 100
....*....|....*....|...
gi 1707017 651 YDMPKHIEMYTHRIGRTGRAGKS 673
Cdd:cd18796 119 IGSPKSVARLLQRLGRSGHRPGA 141
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
562-684 |
1.90e-11 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 67.43 E-value: 1.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 562 EKFFRLQKLLDELGE---KTAIVFVNTKKNCDSIAKNLDKAGYRVTTLHGGKSQEQREISLEGFRAKRYNVLVATDVVGR 638
Cdd:PRK11057 219 EKFKPLDQLMRYVQEqrgKSGIIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGM 298
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1707017 639 GIDIPDVAHVINYDMPKHIEMYTHrigRTGRAGKSGVATSFLTLHD 684
Cdd:PRK11057 299 GINKPNVRFVVHFDIPRNIESYYQ---ETGRAGRDGLPAEAMLFYD 341
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
569-669 |
1.98e-10 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 59.29 E-value: 1.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 569 KLLDELGEKTAIVFVNTKKNCDSIAKNLDK--AGYRVTTLHG--------GKSQEQREISLEGFRAKRYNVLVATDVVGR 638
Cdd:cd18801 23 KKKQEGSDTRVIIFSEFRDSAEEIVNFLSKirPGIRATRFIGqasgksskGMSQKEQKEVIEQFRKGGYNVLVATSIGEE 102
|
90 100 110
....*....|....*....|....*....|..
gi 1707017 639 GIDIPDVAHVINYD-MPKHIEMyTHRIGRTGR 669
Cdd:cd18801 103 GLDIGEVDLIICYDaSPSPIRM-IQRMGRTGR 133
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
624-675 |
2.24e-10 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 57.33 E-value: 2.24e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1707017 624 AKRYNVLVATDVVGRGIDIPDVAHVINYDMPKHIEMYTHRIGRTGRAGKSGV 675
Cdd:cd18785 20 ASSLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEG 71
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
562-697 |
2.73e-10 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 64.15 E-value: 2.73e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 562 EKFFRlQKLLDELGektaIVFVNTKKNCDSIAKNLDKAGYRVTTLHGGKSQEQREISLEGFRAKRYNVLVATDVVGRGID 641
Cdd:PLN03137 671 DKFIK-ENHFDECG----IIYCLSRMDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQWSKDEINIICATVAFGMGIN 745
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1707017 642 IPDVAHVINYDMPKHIEMYTHRIGRTGRAGKSGVATSFLTLHDtevFYDLKQMLVQ 697
Cdd:PLN03137 746 KPDVRFVIHHSLPKSIEGYHQECGRAGRDGQRSSCVLYYSYSD---YIRVKHMISQ 798
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
567-672 |
4.17e-10 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 63.35 E-value: 4.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 567 LQKLLDELGEKTAIVFVNTKKNCDSIAKNLDKAGYRVTTLHG--------GKSQ-EQREIsLEGFRAKRYNVLVATDVVG 637
Cdd:PRK13766 356 VKEQLGKNPDSRIIVFTQYRDTAEKIVDLLEKEGIKAVRFVGqaskdgdkGMSQkEQIEI-LDKFRAGEFNVLVSTSVAE 434
|
90 100 110
....*....|....*....|....*....|....*.
gi 1707017 638 RGIDIPDVAHVINYD-MPKHIEMyTHRIGRTGRAGK 672
Cdd:PRK13766 435 EGLDIPSVDLVIFYEpVPSEIRS-IQRKGRTGRQEE 469
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
563-654 |
2.15e-09 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 56.33 E-value: 2.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 563 KFFRLQKLLDELGEKT--AIVFVNTKKNCDSIAKNLDKAGYRVTTLHGGKSQEQREISLEGFRA-KRYNV-LVATDVVGR 638
Cdd:cd18793 12 KLEALLELLEELREPGekVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEdPDIRVfLLSTKAGGV 91
|
90
....*....|....*.
gi 1707017 639 GIDIPDVAHVINYDMP 654
Cdd:cd18793 92 GLNLTAANRVILYDPW 107
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
309-676 |
3.38e-09 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 60.23 E-value: 3.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 309 PRPMR--SWEESkLTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLayiSRLppMSEENE 386
Cdd:COG1205 29 AREARyaPWPDW-LPPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVL---EAL--LEDPGA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 387 TegpyAVVMAPTRELAQQIEEETVKFAHYLGFRVT-SIVGGQSIEEQGLKITQGCEIVIATPgrliDCL-------ERRY 458
Cdd:COG1205 103 T----ALYLYPTKALARDQLRRLRELAEALGLGVRvATYDGDTPPEERRWIREHPDIVLTNP----DMLhygllphHTRW 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 459 A-VLNQCNYVVLDEAD--RMIdmgFEPQVAGVLDAMpssnlkpeneeeeldekkiyrttymfsatmppgvERLARKYLRN 535
Cdd:COG1205 175 ArFFRNLRYVVIDEAHtyRGV---FGSHVANVLRRL----------------------------------RRICRHYGSD 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 536 PVVV----TIGTA--------GKTTDLISQ--------HVIMMK--ESEKFFR----------LQKLLDElGEKTaIVFV 583
Cdd:COG1205 218 PQFIlasaTIGNPaehaerltGRPVTVVDEdgsprgerTFVLWNppLVDDGIRrsalaeaarlLADLVRE-GLRT-LVFT 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 584 NTKKNCDSIAKNLDKA------GYRVTTLHGG-KSQEQREISlEGFRAKRYNVLVATDVVGRGIDIPDVAHVINYDMPKH 656
Cdd:COG1205 296 RSRRGAELLARYARRAlrepdlADRVAAYRAGyLPEERREIE-RGLRSGELLGVVSTNALELGIDIGGLDAVVLAGYPGT 374
|
410 420
....*....|....*....|
gi 1707017 657 IEMYTHRIGRTGRAGKSGVA 676
Cdd:COG1205 375 RASFWQQAGRAGRRGQDSLV 394
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
557-676 |
4.23e-09 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 56.02 E-value: 4.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 557 MMKESEKFFRLQKLLDELGEKTAIVFVNTKKNCDSIAKNLDKAGYrvttLHGGKSQEQREISLEGFRAKRYNVLVATDVV 636
Cdd:cd18795 24 MNKFDSDIIVLLKIETVSEGKPVLVFCSSRKECEKTAKDLAGIAF----HHAGLTREDRELVEELFREGLIKVLVATSTL 99
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1707017 637 GRGIDIPdvAH--VIN----YDMPKHIEM----YTHRIGRTGRAG--KSGVA 676
Cdd:cd18795 100 AAGVNLP--ARtvIIKgtqrYDGKGYRELspleYLQMIGRAGRPGfdTRGEA 149
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
350-472 |
4.29e-09 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 56.89 E-value: 4.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 350 QRDVIGIAETGSGKTaaFVLPMLAYIsrlppMSEEN---ETEGPYAVVMAPTRELA-QQIEEetvkFAHYLGFRVTSIVG 425
Cdd:cd18034 16 KRNTIVVLPTGSGKT--LIAVMLIKE-----MGELNrkeKNPKKRAVFLVPTVPLVaQQAEA----IRSHTDLKVGEYSG 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1707017 426 GQSIEEQGLKITQGC----EIVIATPGRLIDCLERRYAVLNQCNYVVLDEA 472
Cdd:cd18034 85 EMGVDKWTKERWKEElekyDVLVMTAQILLDALRHGFLSLSDINLLIFDEC 135
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
340-472 |
8.72e-09 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 55.67 E-value: 8.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 340 QMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYIsrlppMSEENETegpyAVVMAPTRELAQQIEEETVKFAHYLGF- 418
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEAL-----LRDPGSR----ALYLYPTKALAQDQLRSLRELLEQLGLg 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1707017 419 -RVTSIVGGQSIEEQGLKITQGCEIVIATPgrliDCLE--------RRYAVLNQCNYVVLDEA 472
Cdd:cd17923 76 iRVATYDGDTPREERRAIIRNPPRILLTNP----DMLHyallphhdRWARFLRNLRYVVLDEA 134
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
560-667 |
9.01e-09 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 58.70 E-value: 9.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 560 ESEKFFRLQKLLDEL---GEKtAIVFVNTKKNCDSIAKNLDKAGYRVTTLHGGKSQEQREISLEGFRAKRYN--VLVATD 634
Cdd:COG0553 531 RSAKLEALLELLEELlaeGEK-VLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEApvFLISLK 609
|
90 100 110
....*....|....*....|....*....|....*....
gi 1707017 635 VVGRGIDIPDVAHVINYDM---PKHIEMYT---HRIGRT 667
Cdd:COG0553 610 AGGEGLNLTAADHVIHYDLwwnPAVEEQAIdraHRIGQT 648
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
339-459 |
9.59e-09 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 56.21 E-value: 9.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 339 IQMAAIPLGLQ-QRDVIGIAETGSGKTAAFVLPMLAYISRLPPMSEENetegPYAVVMAPTRELAQQIEEE-TVKFAHyL 416
Cdd:cd18023 5 IQSEVFPDLLYsDKNFVVSAPTGSGKTVLFELAILRLLKERNPLPWGN----RKVVYIAPIKALCSEKYDDwKEKFGP-L 79
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1707017 417 GFRVTSIVGGQSIEEqgLKITQGCEIVIATPGRLiDCLERRYA 459
Cdd:cd18023 80 GLSCAELTGDTEMDD--TFEIQDADIILTTPEKW-DSMTRRWR 119
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
563-680 |
6.57e-08 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 52.25 E-value: 6.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 563 KFFRLQKLLD--ELGEKTaIVFVNTKKNCDSIAKNLDKAGyrvttLHGGKSQEQREISLEGFRAKRYNVLVATDVVGRGI 640
Cdd:cd18789 35 KLRALEELLKrhEQGDKI-IVFTDNVEALYRYAKRLLKPF-----ITGETPQSEREEILQNFREGEYNTLVVSKVGDEGI 108
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1707017 641 DIPDvAHVInydmpkhIEM---------YTHRIGRTGRAGKSGVATSFL 680
Cdd:cd18789 109 DLPE-ANVA-------IQIsghggsrrqEAQRLGRILRPKKGGGKNAFF 149
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
359-472 |
2.08e-07 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 50.77 E-value: 2.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 359 TGSGKTaafvLPMLAYISRLPpmseenetEGPYAVVmAPTRELAQQIEEETVKFahyLGFRVTSIVGGQSIEEQGlkitq 438
Cdd:cd17926 27 TGSGKT----LTALALIAYLK--------ELRTLIV-VPTDALLDQWKERFEDF---LGDSSIGLIGGGKKKDFD----- 85
|
90 100 110
....*....|....*....|....*....|....
gi 1707017 439 GCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEA 472
Cdd:cd17926 86 DANVVVATYQSLSNLAEEEKDLFDQFGLLIVDEA 119
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
338-472 |
3.74e-07 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 50.72 E-value: 3.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 338 PIQMAAIPLGLQQRD--VIGiAETGSGKTAAFVLPMLAYIsrlppmseenETEGPYAVVMAPTRELAQQIEEETVKFAHY 415
Cdd:cd17921 4 PIQREALRALYLSGDsvLVS-APTSSGKTLIAELAILRAL----------ATSGGKAVYIAPTRALVNQKEADLRERFGP 72
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1707017 416 LGFRVTSIVGGQSIEEQGLkitQGCEIVIATPGRL-IDCLERRYAVLNQCNYVVLDEA 472
Cdd:cd17921 73 LGKNVGLLTGDPSVNKLLL---AEADILVATPEKLdLLLRNGGERLIQDVRLVVVDEA 127
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
334-474 |
4.69e-07 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 50.89 E-value: 4.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 334 KKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRLPpmseenETEGPYAVVMAPTRELAQQIEEetvKFA 413
Cdd:cd17927 1 FKPRNYQLELAQPALKGKNTIICLPTGSGKTFVAVLICEHHLKKFP------AGRKGKVVFLANKVPLVEQQKE---VFR 71
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1707017 414 HYL---GFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAV-LNQCNYVVLDEADR 474
Cdd:cd17927 72 KHFerpGYKVTGLSGDTSENVSVEQIVESSDVIIVTPQILVNDLKSGTIVsLSDFSLLVFDECHN 136
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
566-677 |
5.02e-07 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 49.56 E-value: 5.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 566 RLQKLLDELGEKTaIVFVNTKKNCDSIAKNL-------DKAGYRVTTLHGG-KSQEQREISlEGFRAKRYNVLVATDVVG 637
Cdd:cd18797 26 RLFADLVRAGVKT-IVFCRSRKLAELLLRYLkarlveeGPLASKVASYRAGyLAEDRREIE-AELFNGELLGVVATNALE 103
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1707017 638 RGIDIPDVAHVINYDMPKHIEMYTHRIGRTGRAGKSGVAT 677
Cdd:cd18797 104 LGIDIGGLDAVVLAGYPGSLASLWQQAGRAGRRGKDSLVI 143
|
|
| DEXHc_RLR |
cd18036 |
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense ... |
335-454 |
1.80e-06 |
|
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprise RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). RIG-I-like receptors (RLRs) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350794 [Multi-domain] Cd Length: 204 Bit Score: 49.40 E-value: 1.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 335 KPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRLPPMSEENETegpyaVVMAPTRELAQQieeETVKFAH 414
Cdd:cd18036 2 ELRNYQLELVLPALRGKNTIICAPTGSGKTRVAVYICRHHLEKRRSAGEKGRV-----VVLVNKVPLVEQ---QLEKFFK 73
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1707017 415 YL--GFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCL 454
Cdd:cd18036 74 YFrkGYKVTGLSGDSSHKVSFGQIVKASDVIICTPQILINNL 115
|
|
| SF2_C_EcoAI-like |
cd18799 |
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ... |
579-649 |
5.48e-06 |
|
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350186 [Multi-domain] Cd Length: 116 Bit Score: 46.01 E-value: 5.48e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1707017 579 AIVFVNTKKNCDSIAKNLDKAGYRVTTLHGGKSQEQRE---ISLEGFRAKRYNVLVATDVVGRGIDIPDVAHVI 649
Cdd:cd18799 9 TLIFCVSIEHAEFMAEAFNEAGIDAVALNSDYSDRERGdeaLILLFFGELKPPILVTVDLLTTGVDIPEVDNVV 82
|
|
| SF2_C_RecG |
cd18811 |
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a ... |
594-695 |
5.51e-06 |
|
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. RecG helps process Holliday junction intermediates to mature products by catalyzing branch migration. It is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350198 [Multi-domain] Cd Length: 159 Bit Score: 46.95 E-value: 5.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 594 KNLDKAGYRVTTLHGGKSQEQREISLEGFRAKRYNVLVATDVVGRGIDIPDvAHVInydmpkhIEMYTHRIGRT------ 667
Cdd:cd18811 55 KERFRPELNVGLLHGRLKSDEKDAVMAEFREGEVDILVSTTVIEVGVDVPN-ATVM-------VIEDAERFGLSqlhqlr 126
|
90 100
....*....|....*....|....*...
gi 1707017 668 GRAGKSGVATSFLTLHDTEVFYDLKQML 695
Cdd:cd18811 127 GRVGRGDHQSYCLLVYKDPLTETAKQRL 154
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
357-475 |
1.64e-05 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 45.87 E-value: 1.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 357 AETGSGKTAAFVLPMLAYISRlppmseeneteGPYAVVMAPTRELAQQIEEETVKFahYLGFRVTSIVGGQSieeqgLKI 436
Cdd:cd17918 43 GDVGSGKTLVALGAALLAYKN-----------GKQVAILVPTEILAHQHYEEARKF--LPFINVELVTGGTK-----AQI 104
|
90 100 110
....*....|....*....|....*....|....*....
gi 1707017 437 TQGCEIVIATPGrLIDCLERRYAVlnqcNYVVLDEADRM 475
Cdd:cd17918 105 LSGISLLVGTHA-LLHLDVKFKNL----DLVIVDEQHRF 138
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
333-406 |
4.71e-05 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 46.80 E-value: 4.71e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1707017 333 YKKPSPIQMAAIPLGLQQRDVIGIAETGSGKT-AAFvlpmLAYISRLPPMSEENETE-GPYAVVMAPTRELAQQIE 406
Cdd:PRK13767 30 FGTFTPPQRYAIPLIHEGKNVLISSPTGSGKTlAAF----LAIIDELFRLGREGELEdKVYCLYVSPLRALNNDIH 101
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
508-669 |
5.95e-05 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 46.51 E-value: 5.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 508 KKIYRTTYMF--SATMPPGVERLaRKYLRNPVVVTIgtAGKTTDLISQhvIMMKESEKFFRLQKLLDE------------ 573
Cdd:PHA02653 316 KHIDKIRSLFlmTATLEDDRDRI-KEFFPNPAFVHI--PGGTLFPISE--VYVKNKYNPKNKRAYIEEekknivtalkky 390
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 574 --LGEKTAIVFVNTKKNCDSIAKNLDKA--GYRVTTLHGgKSQEQREISLEGFRAKRYNVLVATDVVGRGIDIPDVAHVi 649
Cdd:PHA02653 391 tpPKGSSGIVFVASVSQCEEYKKYLEKRlpIYDFYIIHG-KVPNIDEILEKVYSSKNPSIIISTPYLESSVTIRNATHV- 468
|
170 180 190
....*....|....*....|....*....|....
gi 1707017 650 nYDM-----PKHI---------EMYTHRIGRTGR 669
Cdd:PHA02653 469 -YDTgrvyvPEPFggkemfiskSMRTQRKGRVGR 501
|
|
| SF2_C_TRCF |
cd18810 |
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair ... |
602-676 |
6.67e-05 |
|
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350197 [Multi-domain] Cd Length: 151 Bit Score: 43.49 E-value: 6.67e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1707017 602 RVTTLHGGKSQEQREISLEGFRAKRYNVLVATDVVGRGIDIPDVAHVI--NYDMPKHIEMYTHRiGRTGRAGKSGVA 676
Cdd:cd18810 53 RIAIAHGQMTENELEEVMLEFAKGEYDILVCTTIIESGIDIPNANTIIieRADKFGLAQLYQLR-GRVGRSKERAYA 128
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
329-472 |
3.26e-04 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 42.52 E-value: 3.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 329 ERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPmlAYISrlppmseenetEGPyAVVMAPTRELAQ-QIEE 407
Cdd:cd17920 6 EVFGYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLP--ALLL-----------DGV-TLVVSPLISLMQdQVDR 71
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1707017 408 etvkfAHYLGFRVTSIVGGQSIEEQ---GLKITQG-CEIVIATPGRL-----IDCLERRYAvLNQCNYVVLDEA 472
Cdd:cd17920 72 -----LQQLGIRAAALNSTLSPEEKrevLLRIKNGqYKLLYVTPERLlspdfLELLQRLPE-RKRLALIVVDEA 139
|
|
| DEXHc_Brr2_2 |
cd18021 |
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type ... |
357-458 |
3.36e-04 |
|
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350779 [Multi-domain] Cd Length: 191 Bit Score: 42.25 E-value: 3.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 357 AETGSGKTAAFVLPMLAYISRLPPMSeenetegpyAVVMAPTRELAQQIEEETV-KFAHYLGFRVTSIVGGQSieeQGLK 435
Cdd:cd18021 26 APTGSGKTVCAELALLRHWRQNPKGR---------AVYIAPMQELVDARYKDWRaKFGPLLGKKVVKLTGETS---TDLK 93
|
90 100
....*....|....*....|...
gi 1707017 436 ITQGCEIVIATPGRLiDCLERRY 458
Cdd:cd18021 94 LLAKSDVILATPEQW-DVLSRRW 115
|
|
| SF2_C_RecG_TRCF |
cd18792 |
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family ... |
601-676 |
3.81e-04 |
|
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family contains recombination factor RecG and transcription-repair coupling factor TrcF. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350179 [Multi-domain] Cd Length: 160 Bit Score: 41.48 E-value: 3.81e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1707017 601 YRVTTLHGGKSQEQREISLEGFRAKRYNVLVATDVVGRGIDIPDVAHVINYDMPKHIEMYTHRI-GRTGRAGKSGVA 676
Cdd:cd18792 61 ARVALLHGKMTEDEKEAVMLEFREGEYDILVSTTVIEVGIDVPNANTMIIEDADRFGLSQLHQLrGRVGRGKHQSYC 137
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
333-406 |
4.59e-04 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 43.55 E-value: 4.59e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1707017 333 YKKPSPIQMAAIPLGLQQRDVIGIAETGSGKT-AAFvlpmLAYISRLPPMSEENETE-GPYAVVMAPTRELAQQIE 406
Cdd:COG1201 22 FGAPTPPQREAWPAIAAGESTLLIAPTGSGKTlAAF----LPALDELARRPRPGELPdGLRVLYISPLKALANDIE 93
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
338-498 |
5.74e-04 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 41.55 E-value: 5.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 338 PIQMAAIPLGLQQ-RDVIGIAETGSGKTaafVLPMLAYISRLppmseeneTEGPYAVVMAPTRELAqqiEEETVKFAHY- 415
Cdd:cd18028 4 PPQAEAVRAGLLKgENLLISIPTASGKT---LIAEMAMVNTL--------LEGGKALYLVPLRALA---SEKYEEFKKLe 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 416 -LGFRVTSIVGGQSIEEQGLKItqgCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEADRMIDMGFEPQVAGVLDAMPSS 494
Cdd:cd18028 70 eIGLKVGISTGDYDEDDEWLGD---YDIIVATYEKFDSLLRHSPSWLRDVGVVVVDEIHLISDEERGPTLESIVARLRRL 146
|
....
gi 1707017 495 NLKP 498
Cdd:cd18028 147 NPNT 150
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
351-471 |
4.79e-03 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 38.33 E-value: 4.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 351 RDVIGIAETGSGKTAAFVLPMLAYISRLPPmseenetEGPYAVVMAPTRELAQQIEE--ETVKFAHYLGFRVTSIVG--G 426
Cdd:cd17922 2 RNVLIAAPTGSGKTEAAFLPALSSLADEPE-------KGVQVLYISPLKALINDQERrlEEPLDEIDLEIPVAVRHGdtS 74
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1707017 427 QSIEEQGLKITQGceIVIATPGRLIDCL--ERRYAVLNQCNYVVLDE 471
Cdd:cd17922 75 QSEKAKQLKNPPG--ILITTPESLELLLvnKKLRELFAGLRYVVVDE 119
|
|
| RecG |
COG1200 |
RecG-like helicase [Replication, recombination and repair]; |
599-643 |
4.92e-03 |
|
RecG-like helicase [Replication, recombination and repair];
Pssm-ID: 440813 [Multi-domain] Cd Length: 684 Bit Score: 40.42 E-value: 4.92e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1707017 599 AGYRVTTLHGG-KSQEQREIsLEGFRAKRYNVLVATDVVGRGIDIP 643
Cdd:COG1200 502 PGLRVGLLHGRmKPAEKDAV-MAAFKAGEIDVLVATTVIEVGVDVP 546
|
|
| PRK10917 |
PRK10917 |
ATP-dependent DNA helicase RecG; Provisional |
587-643 |
4.99e-03 |
|
ATP-dependent DNA helicase RecG; Provisional
Pssm-ID: 236794 [Multi-domain] Cd Length: 681 Bit Score: 40.13 E-value: 4.99e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 587 KNCDSIAKNLDKA--GYRVTTLHG-GKSQEQREIsLEGFRAKRYNVLVATDVVGRGIDIP 643
Cdd:PRK10917 490 QSAEETYEELQEAfpELRVGLLHGrMKPAEKDAV-MAAFKAGEIDILVATTVIEVGVDVP 548
|
|
| SF2_C_suv3 |
cd18805 |
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ... |
580-679 |
7.39e-03 |
|
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350192 [Multi-domain] Cd Length: 135 Bit Score: 37.54 E-value: 7.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 580 IVFvnTKKNCDSIAKNLDKA-GYRVTTLHGGKSQEQREISLEGFRAKR--YNVLVATDVVGRGIDIPdVAHVINYDMPKH 656
Cdd:cd18805 23 VAF--SRKDIFSLKREIEKRtGLKCAVIYGALPPETRRQQARLFNDPEsgYDVLVASDAIGMGLNLN-IRRVIFSSLSKF 99
|
90 100 110
....*....|....*....|....*....|....*
gi 1707017 657 -----IEMYTHRI----GRTGRAG---KSGVATSF 679
Cdd:cd18805 100 dgnemRPLSPSEVkqiaGRAGRFGshfPEGEVTTL 134
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
551-643 |
9.16e-03 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 39.49 E-value: 9.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 551 ISQHVIMMKESEKFFRLQKLLDELGEKTA--------IVFVNTKKNCDSIAknlDKAGYRVTTLHGGKSQEQREISLEGF 622
Cdd:COG1202 394 LERHLTFADGREKIRIINKLVKREFDTKSskgyrgqtIIFTNSRRRCHEIA---RALGYKAAPYHAGLDYGERKKVERRF 470
|
90 100
....*....|....*....|.
gi 1707017 623 RAKRYNVLVATDVVGRGIDIP 643
Cdd:COG1202 471 ADQELAAVVTTAALAAGVDFP 491
|
|
| SF2_C_UvrB |
cd18790 |
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) ... |
573-655 |
9.82e-03 |
|
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) plays a central role in nucleotide excision repair (NER). Together with other components of the NER system, like UvrA, UvrC, UvrD (helicase II), and DNA polymerase I, it recognizes and cleaves damaged DNA in a multistep ATP-dependent reaction. UvrB is critical for the second phase of damage recognition by verifying the nature of the damage and forming the pre-incision complex. Its ATPase site becomes activated in the presence of UvrA and damaged DNA. Its activity is strand destabilization via distortion of the DNA at lesion site, with very limited DNA unwinding. UvrB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350177 [Multi-domain] Cd Length: 171 Bit Score: 37.61 E-value: 9.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707017 573 ELGEKTaIVFVNTKKNCDSIAKNLDKAGYRVTTLHGG-KSQEQREIsLEGFRAKRYNVLVATDVVGRGIDIPDVAHVINY 651
Cdd:cd18790 25 ARGERV-LVTTLTKRMAEDLTEYLQELGVKVRYLHSEiDTLERVEI-IRDLRLGEFDVLVGINLLREGLDLPEVSLVAIL 102
|
....
gi 1707017 652 DMPK 655
Cdd:cd18790 103 DADK 106
|
|
| |
