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Conserved domains on  [gi|5281121|gb|AAD41465|]
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dolichyl-phosphate beta-glucosyltransferase [Homo sapiens]

Protein Classification

dolichyl-phosphate beta-glucosyltransferase( domain architecture ID 10135784)

dolichyl-phosphate beta-glucosyltransferase is a glycosyltransferase family 2 protein that catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate

CAZY:  GT2
EC:  2.4.1.117
Gene Ontology:  GO:0004581|GO:0006486
PubMed:  12200473|10521532|12691742|9445404
SCOP:  3000077

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 69-289 2.29e-124

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


:

Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 354.95  E-value: 2.29e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   69 VVVPSYNEEKRLPVMMDEALSYLEKRqkrdPAFTYEVIVVDDGSKDQTSKVAFKYCQKYGSDkVRVITLVKNRGKGGAIR 148
Cdd:cd04188   1 VVIPAYNEEKRLPPTLEEAVEYLEER----PSFSYEIIVVDDGSKDGTAEVARKLARKNPAL-IRVLTLPKNRGKGGAVR 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121  149 MGIFSSRGEKILMADADGATKFPDVEKLEKglndlQPWPNQMAIACGSRAHLEKESIAQRSYFRTLLMYGFHFLVWFLCV 228
Cdd:cd04188  76 AGMLAARGDYILFADADLATPFEELEKLEE-----ALKTSGYDIAIGSRAHLASAAVVKRSWLRNLLGRGFNFLVRLLLG 150

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 5281121  229 KGIRDTQCGFKLFTREAASRTFSSLHVERWAFDVELLYIAQFFKIPIAEIAVNWTEIEGSK 289
Cdd:cd04188 151 LGIKDTQCGFKLFTRDAARRLFPRLHLERWAFDVELLVLARRLGYPIEEVPVRWVEIPGSK 211
 
Name Accession Description Interval E-value
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 69-289 2.29e-124

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 354.95  E-value: 2.29e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   69 VVVPSYNEEKRLPVMMDEALSYLEKRqkrdPAFTYEVIVVDDGSKDQTSKVAFKYCQKYGSDkVRVITLVKNRGKGGAIR 148
Cdd:cd04188   1 VVIPAYNEEKRLPPTLEEAVEYLEER----PSFSYEIIVVDDGSKDGTAEVARKLARKNPAL-IRVLTLPKNRGKGGAVR 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121  149 MGIFSSRGEKILMADADGATKFPDVEKLEKglndlQPWPNQMAIACGSRAHLEKESIAQRSYFRTLLMYGFHFLVWFLCV 228
Cdd:cd04188  76 AGMLAARGDYILFADADLATPFEELEKLEE-----ALKTSGYDIAIGSRAHLASAAVVKRSWLRNLLGRGFNFLVRLLLG 150

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 5281121  229 KGIRDTQCGFKLFTREAASRTFSSLHVERWAFDVELLYIAQFFKIPIAEIAVNWTEIEGSK 289
Cdd:cd04188 151 LGIKDTQCGFKLFTRDAARRLFPRLHLERWAFDVELLVLARRLGYPIEEVPVRWVEIPGSK 211
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 66-318 2.60e-119

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 346.75  E-value: 2.60e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121    66 QLSVVVPSYNEEKRLPVMMDEALSYLEKRQKRDPAFTYEVIVVDDGSKDQTSKVAFKYCQKYGSDKV--RVITLVKNRGK 143
Cdd:PTZ00260  71 DLSIVIPAYNEEDRLPKMLKETIKYLESRSRKDPKFKYEIIIVNDGSKDKTLKVAKDFWRQNINPNIdiRLLSLLRNKGK 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   144 GGAIRMGIFSSRGEKILMADADGATKFPDVEKLEKGLNDLQPwpNQMAIACGSRAHLEK-ESIAQRSYFRTLLMYGFHFL 222
Cdd:PTZ00260 151 GGAVRIGMLASRGKYILMVDADGATDIDDFDKLEDIMLKIEQ--NGLGIVFGSRNHLVDsDVVAKRKWYRNILMYGFHFI 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   223 VWFLCVKGIRDTQCGFKLFTREAASRTFSSLHVERWAFDVELLYIAQFFKIPIAEIAVNWTEIEGSKLVPFWSWLQMGKD 302
Cdd:PTZ00260 229 VNTICGTNLKDTQCGFKLFTRETARIIFPSLHLERWAFDIEIVMIAQKLNLPIAEVPVNWTEVEGSKLNVISASIQMARD 308

                        250
                 ....*....|....*.
gi 5281121   303 LLFIRLRYLTGAWRLE 318
Cdd:PTZ00260 309 ILLVRSFYLLGIWKVK 324
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 64-288 2.99e-32

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 119.04  E-value: 2.99e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   64 TKQLSVVVPSYNEEKRLPvmmdEALSYLEKRQKRDpaftYEVIVVDDGSKDQTSKVAFKYCQKYgsDKVRVITLVKNRGK 143
Cdd:COG0463   1 MPLVSVVIPTYNEEEYLE----EALESLLAQTYPD----FEIIVVDDGSTDGTAEILRELAAKD--PRIRVIRLERNRGK 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121  144 GGAIRMGIFSSRGEKILMADADGatkFPDVEKLEKGLNDLQPWPNqmAIACGSRAHLEKESIaqrsyFRTLLMYGFHFLV 223
Cdd:COG0463  71 GAARNAGLAAARGDYIAFLDADD---QLDPEKLEELVAALEEGPA--DLVYGSRLIREGESD-----LRRLGSRLFNLVR 140

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 5281121  224 WFLCvkgIRDTQCGFKLFTREAASRTFSSlhvERWAFDVELLYIAQfFKIPIAEIAVNWTEIEGS 288
Cdd:COG0463 141 LLTN---LPDSTSGFRLFRREVLEELGFD---EGFLEDTELLRALR-HGFRIAEVPVRYRAGESK 198
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 68-248 1.25e-25

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 100.55  E-value: 1.25e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121     68 SVVVPSYNEEKRLPVMMDEALsylekRQKRDPaftYEVIVVDDGSKDQTSKVAFKYCQKYgsDKVRVITLVKNRGKGGAI 147
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLL-----NQTYPN---FEIIVVDDGSTDGTVEIAEEYAKKD--PRVRVIRLPENRGKAGAR 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121    148 RMGIFSSRGEKILMADADGATKFPDVEKLEKGLNDLQPwpnqmAIACGSRAHLEKESIAQRSYFRTLLMYGFHFLVWFLC 227
Cdd:pfam00535  71 NAGLRAATGDYIAFLDADDEVPPDWLEKLVEALEEDGA-----DVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLL 145

                         170       180
                  ....*....|....*....|.
gi 5281121    228 VKGIRDTQCGFKLFTREAASR 248
Cdd:pfam00535 146 GLNLPFLIGGFALYRREALEE 166
glyco_like_mftF TIGR04283
transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it ...
 67-172 3.20e-08

transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it sugar moiety, as part of a biosynthetic pathway. Other proposed members of the pathway include another transferase (TIGR04282), a phosphoesterase, and a radical SAM enzyme (TIGR04167) whose C-terminal domain (pfam12345) frequently contains a selenocysteine. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 275103 [Multi-domain]  Cd Length: 220  Bit Score: 53.28  E-value: 3.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121     67 LSVVVPSYNEEKRLPVMMDeALSYLekrqkRDPAftyEVIVVDDGSKDQTSKVAfkycqkyGSDKVRVITLVKNRGKggA 146
Cdd:TIGR04283   1 LSIIIPVLNEAATLPELLA-DLQAL-----RGDA---EVIVVDGGSTDGTVEIA-------RSLGAKVIHSPKGRAR--Q 62

                          90       100
                  ....*....|....*....|....*.
gi 5281121    147 IRMGIFSSRGEKILMADADgaTKFPD 172
Cdd:TIGR04283  63 MNAGAALAKGDILLFLHAD--TRLPK 86
EPS_HpsE NF038302
hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;
67-127 8.28e-06

hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;


Pssm-ID: 439602 [Multi-domain]  Cd Length: 307  Bit Score: 46.71  E-value: 8.28e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 5281121    67 LSVVVPSYNEEKRLPVMMDeALsyleKRQKRDPAFTYEVIVVDDGSKDQTSKVAFKYCQKY 127
Cdd:NF038302   3 FTVAIPTYNGANRLPEVLE-RL----RSQIGTESLSWEIIVVDNNSTDNTAQVVQEYQKNW 58
 
Name Accession Description Interval E-value
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 69-289 2.29e-124

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 354.95  E-value: 2.29e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   69 VVVPSYNEEKRLPVMMDEALSYLEKRqkrdPAFTYEVIVVDDGSKDQTSKVAFKYCQKYGSDkVRVITLVKNRGKGGAIR 148
Cdd:cd04188   1 VVIPAYNEEKRLPPTLEEAVEYLEER----PSFSYEIIVVDDGSKDGTAEVARKLARKNPAL-IRVLTLPKNRGKGGAVR 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121  149 MGIFSSRGEKILMADADGATKFPDVEKLEKglndlQPWPNQMAIACGSRAHLEKESIAQRSYFRTLLMYGFHFLVWFLCV 228
Cdd:cd04188  76 AGMLAARGDYILFADADLATPFEELEKLEE-----ALKTSGYDIAIGSRAHLASAAVVKRSWLRNLLGRGFNFLVRLLLG 150

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 5281121  229 KGIRDTQCGFKLFTREAASRTFSSLHVERWAFDVELLYIAQFFKIPIAEIAVNWTEIEGSK 289
Cdd:cd04188 151 LGIKDTQCGFKLFTRDAARRLFPRLHLERWAFDVELLVLARRLGYPIEEVPVRWVEIPGSK 211
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 66-318 2.60e-119

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 346.75  E-value: 2.60e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121    66 QLSVVVPSYNEEKRLPVMMDEALSYLEKRQKRDPAFTYEVIVVDDGSKDQTSKVAFKYCQKYGSDKV--RVITLVKNRGK 143
Cdd:PTZ00260  71 DLSIVIPAYNEEDRLPKMLKETIKYLESRSRKDPKFKYEIIIVNDGSKDKTLKVAKDFWRQNINPNIdiRLLSLLRNKGK 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   144 GGAIRMGIFSSRGEKILMADADGATKFPDVEKLEKGLNDLQPwpNQMAIACGSRAHLEK-ESIAQRSYFRTLLMYGFHFL 222
Cdd:PTZ00260 151 GGAVRIGMLASRGKYILMVDADGATDIDDFDKLEDIMLKIEQ--NGLGIVFGSRNHLVDsDVVAKRKWYRNILMYGFHFI 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   223 VWFLCVKGIRDTQCGFKLFTREAASRTFSSLHVERWAFDVELLYIAQFFKIPIAEIAVNWTEIEGSKLVPFWSWLQMGKD 302
Cdd:PTZ00260 229 VNTICGTNLKDTQCGFKLFTRETARIIFPSLHLERWAFDIEIVMIAQKLNLPIAEVPVNWTEVEGSKLNVISASIQMARD 308

                        250
                 ....*....|....*.
gi 5281121   303 LLFIRLRYLTGAWRLE 318
Cdd:PTZ00260 309 ILLVRSFYLLGIWKVK 324
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 69-268 1.58e-59

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 188.94  E-value: 1.58e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   69 VVVPSYNEEKRLPVMMDEALSYLEKRqkrdpaFTYEVIVVDDGSKDQTSKVAFKYCQKYGsdKVRVITLVKNRGKGGAIR 148
Cdd:cd04179   1 VVIPAYNEEENIPELVERLLAVLEEG------YDYEIIVVDDGSTDGTAEIARELAARVP--RVRVIRLSRNFGKGAAVR 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121  149 MGIFSSRGEKILMADADGATKFPDVEKLEKGLndlqpWPNQMAIACGSRAHleKESIAQRSYFRTLLMYGFHFLVWFLCV 228
Cdd:cd04179  73 AGFKAARGDIVVTMDADLQHPPEDIPKLLEKL-----LEGGADVVIGSRFV--RGGGAGMPLLRRLGSRLFNFLIRLLLG 145

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 5281121  229 KGIRDTQCGFKLFTREAASRTFSSLHVERWAFDVELLYIA 268
Cdd:cd04179 146 VRISDTQSGFRLFRREVLEALLSLLESNGFEFGLELLVGA 185
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 64-288 2.99e-32

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 119.04  E-value: 2.99e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   64 TKQLSVVVPSYNEEKRLPvmmdEALSYLEKRQKRDpaftYEVIVVDDGSKDQTSKVAFKYCQKYgsDKVRVITLVKNRGK 143
Cdd:COG0463   1 MPLVSVVIPTYNEEEYLE----EALESLLAQTYPD----FEIIVVDDGSTDGTAEILRELAAKD--PRIRVIRLERNRGK 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121  144 GGAIRMGIFSSRGEKILMADADGatkFPDVEKLEKGLNDLQPWPNqmAIACGSRAHLEKESIaqrsyFRTLLMYGFHFLV 223
Cdd:COG0463  71 GAARNAGLAAARGDYIAFLDADD---QLDPEKLEELVAALEEGPA--DLVYGSRLIREGESD-----LRRLGSRLFNLVR 140

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 5281121  224 WFLCvkgIRDTQCGFKLFTREAASRTFSSlhvERWAFDVELLYIAQfFKIPIAEIAVNWTEIEGS 288
Cdd:COG0463 141 LLTN---LPDSTSGFRLFRREVLEELGFD---EGFLEDTELLRALR-HGFRIAEVPVRYRAGESK 198
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 68-248 1.25e-25

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 100.55  E-value: 1.25e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121     68 SVVVPSYNEEKRLPVMMDEALsylekRQKRDPaftYEVIVVDDGSKDQTSKVAFKYCQKYgsDKVRVITLVKNRGKGGAI 147
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLL-----NQTYPN---FEIIVVDDGSTDGTVEIAEEYAKKD--PRVRVIRLPENRGKAGAR 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121    148 RMGIFSSRGEKILMADADGATKFPDVEKLEKGLNDLQPwpnqmAIACGSRAHLEKESIAQRSYFRTLLMYGFHFLVWFLC 227
Cdd:pfam00535  71 NAGLRAATGDYIAFLDADDEVPPDWLEKLVEALEEDGA-----DVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLL 145

                         170       180
                  ....*....|....*....|.
gi 5281121    228 VKGIRDTQCGFKLFTREAASR 248
Cdd:pfam00535 146 GLNLPFLIGGFALYRREALEE 166
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 69-317 1.48e-21

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 91.06  E-value: 1.48e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   69 VVVPSYNEEKRLPVMMDEALSYLEKrqkrdpaFTYEVIVVDDGSKDQTSKVAFKYCQKYGsdKVRVITLVKNRGKGGAIR 148
Cdd:cd06442   1 IIIPTYNERENIPELIERLDAALKG-------IDYEIIVVDDNSPDGTAEIVRELAKEYP--RVRLIVRPGKRGLGSAYI 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121  149 MGIFSSRGEKILMADADG--ATKF-PD-VEKLEKGLNDlqpwpnqmaIACGSRaHLEKESIAQRSYFRTLLMYGFHFLVW 224
Cdd:cd06442  72 EGFKAARGDVIVVMDADLshPPEYiPElLEAQLEGGAD---------LVIGSR-YVEGGGVEGWGLKRKLISRGANLLAR 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121  225 FLCVKGIRDTQCGFKLFTREAASRTFSSLHVERWAFDVELLYIAQFFKIPIAEIAVNWTE-IEG-SKLvpfwSWLQMgkd 302
Cdd:cd06442 142 LLLGRKVSDPTSGFRAYRREVLEKLIDSLVSKGYKFQLELLVRARRLGYRIVEVPITFVDrEHGeSKL----GGKEI--- 214

                       250
                ....*....|....*
gi 5281121  303 llfirLRYLTGAWRL 317
Cdd:cd06442 215 -----VEYLKGLLRL 224
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 69-165 1.27e-18

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 81.40  E-value: 1.27e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   69 VVVPSYNEEKRLPvmmdEALSYLeKRQKRDPaftYEVIVVDDGSKDQTSKVAFKYCQKYgsDKVRVITLVKNRGKGGAIR 148
Cdd:cd00761   1 VIIPAYNEEPYLE----RCLESL-LAQTYPN---FEVIVVDDGSTDGTLEILEEYAKKD--PRVIRVINEENQGLAAARN 70

                        90
                ....*....|....*..
gi 5281121  149 MGIFSSRGEKILMADAD 165
Cdd:cd00761  71 AGLKAARGEYILFLDAD 87
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 61-165 2.67e-18

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 83.64  E-value: 2.67e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   61 DSPTKQLSVVVPSYNEEKRLPvmmdEALSYLeKRQKRdPAFTYEVIVVDDGSKDQTSKVAFKYCQKYgsDKVRVITLVKN 140
Cdd:COG1215  25 PADLPRVSVIIPAYNEEAVIE----ETLRSL-LAQDY-PKEKLEVIVVDDGSTDETAEIARELAAEY--PRVRVIERPEN 96

                        90       100
                ....*....|....*....|....*
gi 5281121  141 RGKGGAIRMGIFSSRGEKILMADAD 165
Cdd:COG1215  97 GGKAAALNAGLKAARGDIVVFLDAD 121
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 69-246 3.76e-18

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 80.60  E-value: 3.76e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   69 VVVPSYNEEKRLPVMMDEALSYLEkrqkrDPAFTYEVIVVDDGSKDQTSKVAFKYCQKYgsDKVRVITLVKNRGKGGAIR 148
Cdd:cd04187   1 IVVPVYNEEENLPELYERLKAVLE-----SLGYDYEIIFVDDGSTDRTLEILRELAARD--PRVKVIRLSRNFGQQAALL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121  149 MGIFSSRGEKILMADADG---ATKFPD-VEKLEKGlNDlqpwpnqmaIACGSRAHlEKESIaqrsyFRTLLMYGFHFLVW 224
Cdd:cd04187  74 AGLDHARGDAVITMDADLqdpPELIPEmLAKWEEG-YD---------VVYGVRKN-RKESW-----LKRLTSKLFYRLIN 137

                       170       180
                ....*....|....*....|..
gi 5281121  225 FLCVKGIRDTQCGFKLFTREAA 246
Cdd:cd04187 138 KLSGVDIPDNGGDFRLMDRKVV 159
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 68-278 8.60e-16

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 75.50  E-value: 8.60e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121    68 SVVVPSYNEEKRLPVMMdealsYLEKRQKRDPAfTYEVIVVDDGSKDQTSKVAFKYCQKYGSDKVRVITLVKNRGKGGAI 147
Cdd:PLN02726  12 SIIVPTYNERLNIALIV-----YLIFKALQDVK-DFEIIVVDDGSPDGTQDVVKQLQKVYGEDRILLRPRPGKLGLGTAY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   148 RMGIFSSRGEKILMADADGA--TKF-PDV--EKLEKGLNdlqpwpnqmaIACGSRaHLEKESIAQRSYFRTLLMYGFHFL 222
Cdd:PLN02726  86 IHGLKHASGDFVVIMDADLShhPKYlPSFikKQRETGAD----------IVTGTR-YVKGGGVHGWDLRRKLTSRGANVL 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 5281121   223 VWFLCVKGIRDTQCGFKLFTREAASRTFSSLHVERWAFDVELLYIAQFFKIPIAEI 278
Cdd:PLN02726 155 AQTLLWPGVSDLTGSFRLYKRSALEDLVSSVVSKGYVFQMEIIVRASRKGYRIEEV 210
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 69-165 5.69e-15

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 71.87  E-value: 5.69e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   69 VVVPSYNEEKRLPvmmdEALSYLeKRQKRDPaftYEVIVVDDGSKDQTSKVAFKYCQKYGSDKVRVITLvKNRGKGGAIR 148
Cdd:cd06423   1 IIVPAYNEEAVIE----RTIESL-LALDYPK---LEVIVVDDGSTDDTLEILEELAALYIRRVLVVRDK-ENGGKAGALN 71

                        90
                ....*....|....*..
gi 5281121  149 MGIFSSRGEKILMADAD 165
Cdd:cd06423  72 AGLRHAKGDIVVVLDAD 88
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
63-165 2.55e-12

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 65.01  E-value: 2.55e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   63 PTKQLSVVVPSYNEEKRLpvmmDEALSYLeKRQKRDPaftYEVIVVDDGSKDQTSKvafkYCQKYGSDKVRVITLVKNRG 142
Cdd:COG1216   1 MRPKVSVVIPTYNRPELL----RRCLESL-LAQTYPP---FEVIVVDNGSTDGTAE----LLAALAFPRVRVIRNPENLG 68

                        90       100
                ....*....|....*....|...
gi 5281121  143 KGGAIRMGIFSSRGEKILMADAD 165
Cdd:COG1216  69 FAAARNLGLRAAGGDYLLFLDDD 91
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 49-165 1.30e-11

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 63.76  E-value: 1.30e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   49 AKGQKETLPSIwdsptkqlSVVVPSYNEEKRLPVMMDE--ALSYlekrqkrdPAFTYEVIVVDDGSKDQTSKVAfkycQK 126
Cdd:cd06439  21 SLPDPAYLPTV--------TIIIPAYNEEAVIEAKLENllALDY--------PRDRLEIIVVSDGSTDGTAEIA----RE 80

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 5281121  127 YGSDKVRVITLVKNRGKGGAIRMGIFSSRGEKILMADAD 165
Cdd:cd06439  81 YADKGVKLLRFPERRGKAAALNRALALATGEIVVFTDAN 119
PRK10714 PRK10714
undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional
 63-165 5.15e-11

undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional


Pssm-ID: 182669 [Multi-domain]  Cd Length: 325  Bit Score: 62.83  E-value: 5.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121    63 PTKQLSVVVPSYNEEKRLPVMMDEALSYLEKRQKRdpaftYEVIVVDDGSKDQTSKVAFKYCQKYGSDKVRVItLVKNRG 142
Cdd:PRK10714   4 PIKKVSVVIPVYNEQESLPELIRRTTAACESLGKE-----YEILLIDDGSSDNSAEMLVEAAQAPDSHIVAIL-LNRNYG 77

                         90       100
                 ....*....|....*....|...
gi 5281121   143 KGGAIRMGIFSSRGEKILMADAD 165
Cdd:PRK10714  78 QHSAIMAGFSHVTGDLIITLDAD 100
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 69-165 1.55e-10

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 59.99  E-value: 1.55e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   69 VVVPSYNEEKRLPVMMD--EALSYlekrqkrdPAFTYEVIVVDDGSKDQTSKVAFKYCQKyGSDKVRVIT--LVKNRGKG 144
Cdd:cd04192   1 VVIAARNEAENLPRLLQslSALDY--------PKEKFEVILVDDHSTDGTVQILEFAAAK-PNFQLKILNnsRVSISGKK 71

                        90       100
                ....*....|....*....|.
gi 5281121  145 GAIRMGIFSSRGEKILMADAD 165
Cdd:cd04192  72 NALTTAIKAAKGDWIVTTDAD 92
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 61-165 1.00e-09

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 58.90  E-value: 1.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121    61 DSPTKQLSVVVPSYNEEKRLPVMMDEALsylekRQKRDpafTYEVIVVDDGSKDQTSKVAFKYCQKYGsdKVRVITLvKN 140
Cdd:PRK10073   2 MNSTPKLSIIIPLYNAGKDFRAFMESLI-----AQTWT---ALEIIIVNDGSTDNSVEIAKHYAENYP--HVRLLHQ-AN 70

                         90       100
                 ....*....|....*....|....*
gi 5281121   141 RGKGGAIRMGIFSSRGEKILMADAD 165
Cdd:PRK10073  71 AGVSVARNTGLAVATGKYVAFPDAD 95
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 68-166 1.27e-09

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 57.63  E-value: 1.27e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   68 SVVVPSYNEEKrlpvmmdealsYLEK-----RQKRDPAFTYEVIVVDDGSKDQTSKVAFKYCQKYGSdkvrvITLVKNRG 142
Cdd:cd02525   3 SIIIPVRNEEK-----------YIEElleslLNQSYPKDLIEIIVVDGGSTDGTREIVQEYAAKDPR-----IRLIDNPK 66

                        90       100
                ....*....|....*....|....*.
gi 5281121  143 K--GGAIRMGIFSSRGEKILMADADG 166
Cdd:cd02525  67 RiqSAGLNIGIRNSRGDIIIRVDAHA 92
glyco_like_mftF TIGR04283
transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it ...
 67-172 3.20e-08

transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it sugar moiety, as part of a biosynthetic pathway. Other proposed members of the pathway include another transferase (TIGR04282), a phosphoesterase, and a radical SAM enzyme (TIGR04167) whose C-terminal domain (pfam12345) frequently contains a selenocysteine. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 275103 [Multi-domain]  Cd Length: 220  Bit Score: 53.28  E-value: 3.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121     67 LSVVVPSYNEEKRLPVMMDeALSYLekrqkRDPAftyEVIVVDDGSKDQTSKVAfkycqkyGSDKVRVITLVKNRGKggA 146
Cdd:TIGR04283   1 LSIIIPVLNEAATLPELLA-DLQAL-----RGDA---EVIVVDGGSTDGTVEIA-------RSLGAKVIHSPKGRAR--Q 62

                          90       100
                  ....*....|....*....|....*.
gi 5281121    147 IRMGIFSSRGEKILMADADgaTKFPD 172
Cdd:TIGR04283  63 MNAGAALAKGDILLFLHAD--TRLPK 86
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 67-143 1.02e-07

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 51.80  E-value: 1.02e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 5281121   67 LSVVVPSYNEEKRLPvmmdEALSYLekRQKRDPAFtyEVIVVDDGSKDQTSKVAfkycQKYGsdkVRVITLVKNRGK 143
Cdd:cd02522   1 LSIIIPTLNEAENLP----RLLASL--RRLNPLPL--EIIVVDGGSTDGTVAIA----RSAG---VVVISSPKGRAR 62
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 67-165 8.76e-07

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 49.29  E-value: 8.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121     67 LSVVVPSYNEEKRLPVMMDEALsylekrqkRDPAFTYEVIVVDDGSKDQTSKVAFKYCQKYGSDKVRVITLVKNRGKGGA 146
Cdd:pfam13641   4 VSVVVPAFNEDSVLGRVLEAIL--------AQPYPPVEVVVVVNPSDAETLDVAEEIAARFPDVRLRVIRNARLLGPTGK 75

                          90       100
                  ....*....|....*....|..
gi 5281121    147 IRM---GIFSSRGEKILMADAD 165
Cdd:pfam13641  76 SRGlnhGFRAVKSDLVVLHDDD 97
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 68-181 3.08e-06

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 47.24  E-value: 3.08e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   68 SVVVPSYNEEKRLpvmmDEAL-SYLEkrQKRDPAftyEVIVVDDGSKDQTSKVAFKYCQKYGsdkvRVITLVKNRGKGGA 146
Cdd:cd04196   1 AVLMATYNGEKYL----REQLdSILA--QTYKND---ELIISDDGSTDGTVEIIKEYIDKDP----FIIILIRNGKNLGV 67

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 5281121  147 IR---MGIFSSRGEKILMADADgatkfpDV---EKLEKGLN 181
Cdd:cd04196  68 ARnfeSLLQAADGDYVFFCDQD------DIwlpDKLERLLK 102
EPS_HpsE NF038302
hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;
67-127 8.28e-06

hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;


Pssm-ID: 439602 [Multi-domain]  Cd Length: 307  Bit Score: 46.71  E-value: 8.28e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 5281121    67 LSVVVPSYNEEKRLPVMMDeALsyleKRQKRDPAFTYEVIVVDDGSKDQTSKVAFKYCQKY 127
Cdd:NF038302   3 FTVAIPTYNGANRLPEVLE-RL----RSQIGTESLSWEIIVVDNNSTDNTAQVVQEYQKNW 58
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 69-160 3.15e-04

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 40.62  E-value: 3.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   69 VVVPSYNEEKRLPvmmdEALSYLEKRQKRDpaftYEVIVVDDGSKDQTSKVAFKYcqkygSDKVRVITLVKNRGKGGAIR 148
Cdd:cd04186   1 IIIVNYNSLEYLK----ACLDSLLAQTYPD----FEVIVVDNASTDGSVELLREL-----FPEVRLIRNGENLGFGAGNN 67

                        90
                ....*....|..
gi 5281121  149 MGIFSSRGEKIL 160
Cdd:cd04186  68 QGIREAKGDYVL 79
GT2_AmsE_like cd04195
GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a ...
 68-165 1.01e-03

GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133038 [Multi-domain]  Cd Length: 201  Bit Score: 39.61  E-value: 1.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   68 SVVVPSYNEEKrlPVMMDEALSYLEKrQKRDPAftyEVIVVDDGSKDQT-SKVAFKYCQKYGsdkVRVITLVKNRGKGGA 146
Cdd:cd04195   1 SVLMSVYIKEK--PEFLREALESILK-QTLPPD---EVVLVKDGPVTQSlNEVLEEFKRKLP---LKVVPLEKNRGLGKA 71

                        90
                ....*....|....*....
gi 5281121  147 IRMGIFSSRGEKILMADAD 165
Cdd:cd04195  72 LNEGLKHCTYDWVARMDTD 90
GT2_HAS cd06434
Hyaluronan synthases catalyze polymerization of hyaluronan; Hyaluronan synthases (HASs) are ...
 67-165 1.49e-03

Hyaluronan synthases catalyze polymerization of hyaluronan; Hyaluronan synthases (HASs) are bi-functional glycosyltransferases that catalyze polymerization of hyaluronan. HASs transfer both GlcUA and GlcNAc in beta-(1,3) and beta-(1,4) linkages, respectively to the hyaluronan chain using UDP-GlcNAc and UDP-GlcUA as substrates. HA is made as a free glycan, not attached to a protein or lipid. HASs do not need a primer for HA synthesis; they initiate HA biosynthesis de novo with only UDP-GlcNAc, UDP-GlcUA, and Mg2+. Hyaluronan (HA) is a linear heteropolysaccharide composed of (1-3)-linked beta-D-GlcUA-beta-D-GlcNAc disaccharide repeats. It can be found in vertebrates and a few microbes and is typically on the cell surface or in the extracellular space, but is also found inside mammalian cells. Hyaluronan has several physiochemical and biological functions such as space filling, lubrication, and providing a hydrated matrix through which cells can migrate.


Pssm-ID: 133056 [Multi-domain]  Cd Length: 235  Bit Score: 39.54  E-value: 1.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   67 LSVVVPSYneekrlpvmmDEALSYLEK------RQKRDpaftyEVIVVDDGSKDqtsKVAFKYCQKYGSDKVRVITlVKN 140
Cdd:cd06434   2 VTVIIPVY----------DEDPDVFREclrsilRQKPL-----EIIVVTDGDDE---PYLSILSQTVKYGGIFVIT-VPH 62

                        90       100
                ....*....|....*....|....*
gi 5281121  141 RGKGGAIRMGIFSSRGEKILMADAD 165
Cdd:cd06434  63 PGKRRALAEGIRHVTTDIVVLLDSD 87
Glyco_tranf_2_2 pfam10111
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 68-204 2.75e-03

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 313356 [Multi-domain]  Cd Length: 276  Bit Score: 38.80  E-value: 2.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121     68 SVVVPSYNEEKRLPVMmdEALsyLEKRQKRDPAFtyEVIVVDDGSKDQTSKVAFKYCQKYGSDKVRVITlVKNRGKGGAI 147
Cdd:pfam10111   1 SVVIPVYNGEKTHWIQ--ERI--LNQTFQYDPEF--ELIIINDGSTDKTLEEVSSIKDHNLQVYYPNAP-DTTYSLAASR 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 5281121    148 RMGIFSSRGEKILMADADGATKFPDVEKLEKGLNDLQPWPNQMAIACGSRAHLEKES 204
Cdd:pfam10111  74 NRGTSHAIGEYISFIDGDCLWSPDKFEKQLKIATSLALQENIQAAVVLPVTDLNDES 130
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 68-168 2.80e-03

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 38.30  E-value: 2.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   68 SVVVPSYNEEKRLPvmmdEAL-SYLEkrQKRDpafTYEVIVVDDGSKDQTSKVAfkycQKYGSDKVRVITlVKNRGKGGA 146
Cdd:cd06433   1 SIITPTYNQAETLE----ETIdSVLS--QTYP---NIEYIVIDGGSTDGTVDII----KKYEDKITYWIS-EPDKGIYDA 66

                        90       100
                ....*....|....*....|....*..
gi 5281121  147 IRMGIFSSRGEKI--LMAD---ADGAT 168
Cdd:cd06433  67 MNKGIALATGDIIgfLNSDdtlLPGAL 93
CESA_NdvC_like cd06435
NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; ...
 68-165 3.00e-03

NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase. Bradyrhizobium japonicum synthesizes periplasmic cyclic beta-(1,3),beta-(1,6)-D-glucans during growth under hypoosmotic conditions. Two genes (ndvB, ndvC) are involved in the beta-(1, 3), beta-(1,6)-glucan synthesis. The ndvC mutant strain resulted in synthesis of altered cyclic beta-glucans composed almost entirely of beta-(1, 3)-glycosyl linkages. The periplasmic cyclic beta-(1,3),beta-(1,6)-D-glucans function for osmoregulation. The ndvC mutation also affects the ability of the bacteria to establish a successful symbiotic interaction with host plant. Thus, the beta-glucans may function as suppressors of a host defense response.


Pssm-ID: 133057 [Multi-domain]  Cd Length: 236  Bit Score: 38.54  E-value: 3.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   68 SVVVPSYNEEkrlPVMMDEALSYLekRQKRDPAFtyEVIVVDDGSKDQT-SKVAFKYCQKYGsDKVRVITLVKNRG-KGG 145
Cdd:cd06435   1 SIHVPCYEEP---PEMVKETLDSL--AALDYPNF--EVIVIDNNTKDEAlWKPVEAHCAQLG-ERFRFFHVEPLPGaKAG 72

                        90       100
                ....*....|....*....|..
gi 5281121  146 AIR--MGIFSSRGEKILMADAD 165
Cdd:cd06435  73 ALNyaLERTAPDAEIIAVIDAD 94
pp-GalNAc-T cd02510
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide ...
 68-142 4.03e-03

pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferases (pp-GalNAc-T) initiate the formation of mucin-type, O-linked glycans by catalyzing the transfer of alpha-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to hydroxyl groups of Ser or Thr residues of core proteins to form the Tn antigen (GalNAc-a-1-O-Ser/Thr). These enzymes are type II membrane proteins with a GT-A type catalytic domain and a lectin domain located on the lumen side of the Golgi apparatus. In human, there are 15 isozymes of pp-GalNAc-Ts, representing the largest of all glycosyltransferase families. Each isozyme has unique but partially redundant substrate specificity for glycosylation sites on acceptor proteins.


Pssm-ID: 133004 [Multi-domain]  Cd Length: 299  Bit Score: 38.34  E-value: 4.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   68 SVVVPSYNEekrlpvmmdeALSYLEK-----RQKRDPAFTYEVIVVDDGSKDQTSKVAFKYCQKYGSDKVRVITLVKNRG 142
Cdd:cd02510   1 SVIIIFHNE----------ALSTLLRtvhsvINRTPPELLKEIILVDDFSDKPELKLLLEEYYKKYLPKVKVLRLKKREG 70
CESA_CelA_like cd06421
CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Family of ...
 69-165 5.59e-03

CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Family of proteins related to Agrobacterium tumefaciens CelA and Gluconacetobacter xylinus BscA. These proteins are involved in the elongation of the glucan chain of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues. They are putative catalytic subunit of cellulose synthase, which is a glycosyltransferase using UDP-glucose as the substrate. The catalytic subunit is an integral membrane protein with 6 transmembrane segments and it is postulated that the protein is anchored in the membrane at the N-terminal end.


Pssm-ID: 133043 [Multi-domain]  Cd Length: 234  Bit Score: 37.55  E-value: 5.59e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   69 VVVPSYNEEkrlpvmmdeaLSYLEK-----RQKRDPAFTYEVIVVDDGSKDQTSKVAFKYCQKYGsdkVRVITLVKNRG- 142
Cdd:cd06421   5 VFIPTYNEP----------LEIVRKtlraaLAIDYPHDKLRVYVLDDGRRPELRALAAELGVEYG---YRYLTRPDNRHa 71

                        90       100
                ....*....|....*....|...
gi 5281121  143 KGGAIRMGIFSSRGEKILMADAD 165
Cdd:cd06421  72 KAGNLNNALAHTTGDFVAILDAD 94
GT2_Chondriotin_Pol_N cd06420
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin ...
 69-126 7.16e-03

N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.


Pssm-ID: 133042 [Multi-domain]  Cd Length: 182  Bit Score: 36.79  E-value: 7.16e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 5281121   69 VVVPSYNEEKRLPVMMDealSYLekRQKRDPaftYEVIVVDDGSKDQTSKVAFKYCQK 126
Cdd:cd06420   1 LIITTYNRPEALELVLK---SVL--NQSILP---FEVIIADDGSTEETKELIEEFKSQ 50
GT2_RfbC_Mx_like cd04184
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene ...
 67-165 9.95e-03

Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133027 [Multi-domain]  Cd Length: 202  Bit Score: 36.80  E-value: 9.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5281121   67 LSVVVPSYN-EEKRLpvmmDEALSYLeKRQkrdpafTY---EVIVVDDGS-KDQTSKVAFKYCQKygSDKVRVITLVKNR 141
Cdd:cd04184   3 ISIVMPVYNtPEKYL----REAIESV-RAQ------TYpnwELCIADDAStDPEVKRVLKKYAAQ--DPRIKVVFREENG 69

                        90       100
                ....*....|....*....|....
gi 5281121  142 GKGGAIRMGIFSSRGEKILMADAD 165
Cdd:cd04184  70 GISAATNSALELATGEFVALLDHD 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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