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Conserved domains on  [gi|6671346|gb|AAF23167|]
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BeTX toxin precursor [Conus betulinus]

Protein Classification

Conotoxin_I2 domain-containing protein( domain architecture ID 13880662)

Conotoxin_I2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Conotoxin_I2 pfam17557
I2-superfamily conotoxins; Conotoxins (or conopeptides) are the peptidic components of the ...
 27-64 3.05e-14

I2-superfamily conotoxins; Conotoxins (or conopeptides) are the peptidic components of the venoms of marine cone snails (genus Conus). They are classified in one of three ways: gene superfamily, cysteine framework or pharmacological family. Several distinct cysteine frameworks have been described in conotoxins. Members of this family display a XI cysteine pattern (C-C-CC-CC-C-C) and belong to the I2- superfamily conotoxins. Family members such as Kappa-conotoxin ViTx and Kappa-conotoxin SrXIA inhibit voltage gated potassium channels (Kv).


:

Pssm-ID: 375216  Cd Length: 38  Bit Score: 59.67  E-value: 3.05e-14
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 6671346    27 CRAEGTYCENDSQCCLNECCWGGCGHPCRHPGKRSKLQ 64
Cdd:pfam17557  1 CRPEGSSCTYDSQCCLSSCCSGTCSLPCRIPGKRAKLQ 38
 
Name Accession Description Interval E-value
Conotoxin_I2 pfam17557
I2-superfamily conotoxins; Conotoxins (or conopeptides) are the peptidic components of the ...
 27-64 3.05e-14

I2-superfamily conotoxins; Conotoxins (or conopeptides) are the peptidic components of the venoms of marine cone snails (genus Conus). They are classified in one of three ways: gene superfamily, cysteine framework or pharmacological family. Several distinct cysteine frameworks have been described in conotoxins. Members of this family display a XI cysteine pattern (C-C-CC-CC-C-C) and belong to the I2- superfamily conotoxins. Family members such as Kappa-conotoxin ViTx and Kappa-conotoxin SrXIA inhibit voltage gated potassium channels (Kv).


Pssm-ID: 375216  Cd Length: 38  Bit Score: 59.67  E-value: 3.05e-14
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 6671346    27 CRAEGTYCENDSQCCLNECCWGGCGHPCRHPGKRSKLQ 64
Cdd:pfam17557  1 CRPEGSSCTYDSQCCLSSCCSGTCSLPCRIPGKRAKLQ 38
 
Name Accession Description Interval E-value
Conotoxin_I2 pfam17557
I2-superfamily conotoxins; Conotoxins (or conopeptides) are the peptidic components of the ...
 27-64 3.05e-14

I2-superfamily conotoxins; Conotoxins (or conopeptides) are the peptidic components of the venoms of marine cone snails (genus Conus). They are classified in one of three ways: gene superfamily, cysteine framework or pharmacological family. Several distinct cysteine frameworks have been described in conotoxins. Members of this family display a XI cysteine pattern (C-C-CC-CC-C-C) and belong to the I2- superfamily conotoxins. Family members such as Kappa-conotoxin ViTx and Kappa-conotoxin SrXIA inhibit voltage gated potassium channels (Kv).


Pssm-ID: 375216  Cd Length: 38  Bit Score: 59.67  E-value: 3.05e-14
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 6671346    27 CRAEGTYCENDSQCCLNECCWGGCGHPCRHPGKRSKLQ 64
Cdd:pfam17557  1 CRPEGSSCTYDSQCCLSSCCSGTCSLPCRIPGKRAKLQ 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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