NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|8248449|gb|AAF74203|]
View 

purinoceptor P2X2H [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
P2X_receptor super family cl02993
ATP P2X receptor;
36-286 2.82e-158

ATP P2X receptor;


The actual alignment was detected with superfamily member TIGR00863:

Pssm-ID: 470714  Cd Length: 372  Bit Score: 449.18  E-value: 2.82e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8248449     36 SIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYyQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPK 115
Cdd:TIGR00863 121 HPSVPLAICWSDSDCTAGEAGTHGNGIKTGRCVPF-NGTVKTCEIFAWCPVEVDTVPSPPLLKEAENFTLFIKNSIRFPK 199
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8248449    116 FHFSKGNIADRTDG-YLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFR 194
Cdd:TIGR00863 200 FNFSKRNILETWDAtYLKTCLFDPDSDPYCPIFRLGDIVEEAGQDFQDLALKGGVVGITINWDCDLDKAASHCNPKYSFR 279
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8248449    195 RLDPKHVPASSGYNFRFAKYYKIN-GTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLT 273
Cdd:TIGR00863 280 RLDNKEKNVSPGYNFRFAKYYRDNaGVETRTLLKAYGIRFDILVTGKAGKFDIIPTMITIGSGLASLGVGTFLCDLILLY 359
                         250
                  ....*....|...
gi 8248449    274 FMNKNKVYSHKKF 286
Cdd:TIGR00863 360 FMKKRHFYRDKKF 372
 
Name Accession Description Interval E-value
P2X TIGR00863
cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC ...
36-286 2.82e-158

cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC family (also called P2X receptors) respond to ATP, a functional neurotransmitter released by exocytosis from many types of neurons.These channels, which function at neuron-neuron and neuron-smooth muscle junctions, may play roles in the control of blood pressure and pain sensation. They may also function in lymphocyte and plateletphysiology. They are found only in animals.ACC channels are probably hetero- or homomultimers and transport small monovalent cations (Me+). Some also transport Ca2+; a few also transport small metabolites. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273307  Cd Length: 372  Bit Score: 449.18  E-value: 2.82e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8248449     36 SIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYyQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPK 115
Cdd:TIGR00863 121 HPSVPLAICWSDSDCTAGEAGTHGNGIKTGRCVPF-NGTVKTCEIFAWCPVEVDTVPSPPLLKEAENFTLFIKNSIRFPK 199
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8248449    116 FHFSKGNIADRTDG-YLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFR 194
Cdd:TIGR00863 200 FNFSKRNILETWDAtYLKTCLFDPDSDPYCPIFRLGDIVEEAGQDFQDLALKGGVVGITINWDCDLDKAASHCNPKYSFR 279
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8248449    195 RLDPKHVPASSGYNFRFAKYYKIN-GTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLT 273
Cdd:TIGR00863 280 RLDNKEKNVSPGYNFRFAKYYRDNaGVETRTLLKAYGIRFDILVTGKAGKFDIIPTMITIGSGLASLGVGTFLCDLILLY 359
                         250
                  ....*....|...
gi 8248449    274 FMNKNKVYSHKKF 286
Cdd:TIGR00863 360 FMKKRHFYRDKKF 372
P2X_receptor pfam00864
ATP P2X receptor;
43-288 6.41e-142

ATP P2X receptor;


Pssm-ID: 459968  Cd Length: 362  Bit Score: 407.32  E-value: 6.41e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8248449     43 TCLSDADCVAGELDMLGNGLRTGRCVPYYQGPsKTCEVFGWCPVE-DGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKG 121
Cdd:pfam00864 113 NCTSDQDCGAGEGKPVGNGIQTGRCVPFNWTT-KTCEIFGWCPVElDTAPPFPPLLKNAENFTVFIKNSIRFPKFNFSRR 191
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8248449    122 NIADRTD-GYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKH 200
Cdd:pfam00864 192 NILPQYDkTYLKTCTYHPLTDPYCPIFRLGDIVAEAGENFSELANKGGVIGIKINWDCDLDSDRSHCNPKYSFRRLDGKN 271
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8248449    201 V--PASSGYNFRFAKYYK-INGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNK 277
Cdd:pfam00864 272 FnnAVSPGYNFRFAKYYKeKNGVERRTLIKAYGIRFDIIVFGKAGKFSIIPTIINIGSGLALLGVATVLCDLILLYFLKK 351
                         250
                  ....*....|.
gi 8248449    278 NKVYSHKKFDK 288
Cdd:pfam00864 352 REFYYDKKFEE 362
 
Name Accession Description Interval E-value
P2X TIGR00863
cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC ...
36-286 2.82e-158

cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC family (also called P2X receptors) respond to ATP, a functional neurotransmitter released by exocytosis from many types of neurons.These channels, which function at neuron-neuron and neuron-smooth muscle junctions, may play roles in the control of blood pressure and pain sensation. They may also function in lymphocyte and plateletphysiology. They are found only in animals.ACC channels are probably hetero- or homomultimers and transport small monovalent cations (Me+). Some also transport Ca2+; a few also transport small metabolites. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273307  Cd Length: 372  Bit Score: 449.18  E-value: 2.82e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8248449     36 SIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYyQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPK 115
Cdd:TIGR00863 121 HPSVPLAICWSDSDCTAGEAGTHGNGIKTGRCVPF-NGTVKTCEIFAWCPVEVDTVPSPPLLKEAENFTLFIKNSIRFPK 199
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8248449    116 FHFSKGNIADRTDG-YLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFR 194
Cdd:TIGR00863 200 FNFSKRNILETWDAtYLKTCLFDPDSDPYCPIFRLGDIVEEAGQDFQDLALKGGVVGITINWDCDLDKAASHCNPKYSFR 279
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8248449    195 RLDPKHVPASSGYNFRFAKYYKIN-GTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLT 273
Cdd:TIGR00863 280 RLDNKEKNVSPGYNFRFAKYYRDNaGVETRTLLKAYGIRFDILVTGKAGKFDIIPTMITIGSGLASLGVGTFLCDLILLY 359
                         250
                  ....*....|...
gi 8248449    274 FMNKNKVYSHKKF 286
Cdd:TIGR00863 360 FMKKRHFYRDKKF 372
P2X_receptor pfam00864
ATP P2X receptor;
43-288 6.41e-142

ATP P2X receptor;


Pssm-ID: 459968  Cd Length: 362  Bit Score: 407.32  E-value: 6.41e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8248449     43 TCLSDADCVAGELDMLGNGLRTGRCVPYYQGPsKTCEVFGWCPVE-DGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKG 121
Cdd:pfam00864 113 NCTSDQDCGAGEGKPVGNGIQTGRCVPFNWTT-KTCEIFGWCPVElDTAPPFPPLLKNAENFTVFIKNSIRFPKFNFSRR 191
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8248449    122 NIADRTD-GYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKH 200
Cdd:pfam00864 192 NILPQYDkTYLKTCTYHPLTDPYCPIFRLGDIVAEAGENFSELANKGGVIGIKINWDCDLDSDRSHCNPKYSFRRLDGKN 271
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8248449    201 V--PASSGYNFRFAKYYK-INGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNK 277
Cdd:pfam00864 272 FnnAVSPGYNFRFAKYYKeKNGVERRTLIKAYGIRFDIIVFGKAGKFSIIPTIINIGSGLALLGVATVLCDLILLYFLKK 351
                         250
                  ....*....|.
gi 8248449    278 NKVYSHKKFDK 288
Cdd:pfam00864 352 REFYYDKKFEE 362
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH