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Conserved domains on  [gi|9230804|gb|AAF82181|]
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ComX [Bacillus subtilis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ComX super family cl05488
Bacillus competence pheromone ComX; Natural genetic competence in Bacillus subtilis is ...
 1-54 6.08e-08

Bacillus competence pheromone ComX; Natural genetic competence in Bacillus subtilis is controlled by quorum-sensing (QS). The ComP- ComA two-component system detects the signalling molecule ComX, and this signal is transduced by a conserved phosphotransfer mechanism. ComX is synthesized as an inactive precursor and is then cleaved and modified by ComQ before export to the extracellular environment. This family includes ComX phermones involved in quorum sensing. Amino acid sequence alignments between the two ComX precursor proteins in B. licheniformis, showed that their conservation is only restricted to the N-terminal ends. Moreover, high diversity in the amino acid sequence in C-terminus marked the pheromone-forming region, where, interestingly, the tryptophan residue is located.


The actual alignment was detected with superfamily member pfam05952:

Pssm-ID: 368681  Cd Length: 55  Bit Score: 43.50  E-value: 6.08e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 9230804     1 MQELISYLLKYPEVLKKLKSNEASLIGFSSDETQLIIEGFEGIEEVKRGNAGKW 54
Cdd:pfam05952  2 LQEVVEYLVENPDVLEQLQNGNASLIGLSEEEQKAILDVFQEEDSIELRPMSYW 55
 
Name Accession Description Interval E-value
ComX pfam05952
Bacillus competence pheromone ComX; Natural genetic competence in Bacillus subtilis is ...
 1-54 6.08e-08

Bacillus competence pheromone ComX; Natural genetic competence in Bacillus subtilis is controlled by quorum-sensing (QS). The ComP- ComA two-component system detects the signalling molecule ComX, and this signal is transduced by a conserved phosphotransfer mechanism. ComX is synthesized as an inactive precursor and is then cleaved and modified by ComQ before export to the extracellular environment. This family includes ComX phermones involved in quorum sensing. Amino acid sequence alignments between the two ComX precursor proteins in B. licheniformis, showed that their conservation is only restricted to the N-terminal ends. Moreover, high diversity in the amino acid sequence in C-terminus marked the pheromone-forming region, where, interestingly, the tryptophan residue is located.


Pssm-ID: 368681  Cd Length: 55  Bit Score: 43.50  E-value: 6.08e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 9230804     1 MQELISYLLKYPEVLKKLKSNEASLIGFSSDETQLIIEGFEGIEEVKRGNAGKW 54
Cdd:pfam05952  2 LQEVVEYLVENPDVLEQLQNGNASLIGLSEEEQKAILDVFQEEDSIELRPMSYW 55
 
Name Accession Description Interval E-value
ComX pfam05952
Bacillus competence pheromone ComX; Natural genetic competence in Bacillus subtilis is ...
 1-54 6.08e-08

Bacillus competence pheromone ComX; Natural genetic competence in Bacillus subtilis is controlled by quorum-sensing (QS). The ComP- ComA two-component system detects the signalling molecule ComX, and this signal is transduced by a conserved phosphotransfer mechanism. ComX is synthesized as an inactive precursor and is then cleaved and modified by ComQ before export to the extracellular environment. This family includes ComX phermones involved in quorum sensing. Amino acid sequence alignments between the two ComX precursor proteins in B. licheniformis, showed that their conservation is only restricted to the N-terminal ends. Moreover, high diversity in the amino acid sequence in C-terminus marked the pheromone-forming region, where, interestingly, the tryptophan residue is located.


Pssm-ID: 368681  Cd Length: 55  Bit Score: 43.50  E-value: 6.08e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 9230804     1 MQELISYLLKYPEVLKKLKSNEASLIGFSSDETQLIIEGFEGIEEVKRGNAGKW 54
Cdd:pfam05952  2 LQEVVEYLVENPDVLEQLQNGNASLIGLSEEEQKAILDVFQEEDSIELRPMSYW 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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