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Conserved domains on  [gi|12667566|gb|AAG61187|]
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dissimilatory sulfite reductase subunit A, partial [uncultured sulfate-reducing bacterium UMTRAdsr626-23]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
dsrA super family cl37041
sulfite reductase, dissimilatory-type alpha subunit; Dissimilatory sulfite reductase catalyzes ...
 1-121 1.15e-60

sulfite reductase, dissimilatory-type alpha subunit; Dissimilatory sulfite reductase catalyzes the six-electron reduction of sulfite to sulfide, as the terminal reaction in dissimilatory sulfate reduction. It remains unclear however, whether trithionate and thiosulfate serve as intermediate compounds to sulfide, or as end products of sulfite reduction. Sulfite reductase is a multisubunit enzyme composed of dimers of either alpha/beta or alpha/beta/gamma subunits, each containing a siroheme and iron sulfur cluster prosthetic center. Found in sulfate-reducing bacteria, these genes are commonly located in an unidirectional gene cluster. This model describes the alpha subunit of sulfite reductase. [Central intermediary metabolism, Sulfur metabolism]


The actual alignment was detected with superfamily member TIGR02064:

Pssm-ID: 273948 [Multi-domain]  Cd Length: 402  Bit Score: 190.82  E-value: 1.15e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12667566     1 VIGRYSDQPDMFPGVAQFHTLRVNQPAGKFYKTAFLKKLCDLWEFRGSGLTNMHGSTGDIILLGTTTAQLEEIFYEMThN 80
Cdd:TIGR02064  64 VIGRYSDQGEKFPGVAEFHTVRVAQPSGKFYSTDYLRQLCDVWEKYGSGLTNFHGQTGDIVFLGTQTPQLQEIFEELT-N 142

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 12667566    81 LQQDLGGSGSNLRTPSDCIGQARCEYACYDTQALCHSLTMD 121
Cdd:TIGR02064 143 LGTDLGGSGSNLRTPESCVGPARCEFACYDTLKACYELTME 183
 
Name Accession Description Interval E-value
dsrA TIGR02064
sulfite reductase, dissimilatory-type alpha subunit; Dissimilatory sulfite reductase catalyzes ...
 1-121 1.15e-60

sulfite reductase, dissimilatory-type alpha subunit; Dissimilatory sulfite reductase catalyzes the six-electron reduction of sulfite to sulfide, as the terminal reaction in dissimilatory sulfate reduction. It remains unclear however, whether trithionate and thiosulfate serve as intermediate compounds to sulfide, or as end products of sulfite reduction. Sulfite reductase is a multisubunit enzyme composed of dimers of either alpha/beta or alpha/beta/gamma subunits, each containing a siroheme and iron sulfur cluster prosthetic center. Found in sulfate-reducing bacteria, these genes are commonly located in an unidirectional gene cluster. This model describes the alpha subunit of sulfite reductase. [Central intermediary metabolism, Sulfur metabolism]


Pssm-ID: 273948 [Multi-domain]  Cd Length: 402  Bit Score: 190.82  E-value: 1.15e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12667566     1 VIGRYSDQPDMFPGVAQFHTLRVNQPAGKFYKTAFLKKLCDLWEFRGSGLTNMHGSTGDIILLGTTTAQLEEIFYEMThN 80
Cdd:TIGR02064  64 VIGRYSDQGEKFPGVAEFHTVRVAQPSGKFYSTDYLRQLCDVWEKYGSGLTNFHGQTGDIVFLGTQTPQLQEIFEELT-N 142

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 12667566    81 LQQDLGGSGSNLRTPSDCIGQARCEYACYDTQALCHSLTMD 121
Cdd:TIGR02064 143 LGTDLGGSGSNLRTPESCVGPARCEFACYDTLKACYELTME 183
 
Name Accession Description Interval E-value
dsrA TIGR02064
sulfite reductase, dissimilatory-type alpha subunit; Dissimilatory sulfite reductase catalyzes ...
 1-121 1.15e-60

sulfite reductase, dissimilatory-type alpha subunit; Dissimilatory sulfite reductase catalyzes the six-electron reduction of sulfite to sulfide, as the terminal reaction in dissimilatory sulfate reduction. It remains unclear however, whether trithionate and thiosulfate serve as intermediate compounds to sulfide, or as end products of sulfite reduction. Sulfite reductase is a multisubunit enzyme composed of dimers of either alpha/beta or alpha/beta/gamma subunits, each containing a siroheme and iron sulfur cluster prosthetic center. Found in sulfate-reducing bacteria, these genes are commonly located in an unidirectional gene cluster. This model describes the alpha subunit of sulfite reductase. [Central intermediary metabolism, Sulfur metabolism]


Pssm-ID: 273948 [Multi-domain]  Cd Length: 402  Bit Score: 190.82  E-value: 1.15e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12667566     1 VIGRYSDQPDMFPGVAQFHTLRVNQPAGKFYKTAFLKKLCDLWEFRGSGLTNMHGSTGDIILLGTTTAQLEEIFYEMThN 80
Cdd:TIGR02064  64 VIGRYSDQGEKFPGVAEFHTVRVAQPSGKFYSTDYLRQLCDVWEKYGSGLTNFHGQTGDIVFLGTQTPQLQEIFEELT-N 142

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 12667566    81 LQQDLGGSGSNLRTPSDCIGQARCEYACYDTQALCHSLTMD 121
Cdd:TIGR02064 143 LGTDLGGSGSNLRTPESCVGPARCEFACYDTLKACYELTME 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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