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Conserved domains on  [gi|12652991|gb|AAH00256|]
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Similar to somatostatin receptor 2, partial [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
1-226 8.53e-138

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15971:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 279  Bit Score: 389.20  E-value: 8.53e-138
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd15971  55 FLAIQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPI 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLRSnQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRM 160
Cdd:cd15971 135 MIYAGVQT-KHGRSSCTIIWPGESSAWYTGFIIYTFILGFFVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRM 213
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 161 VSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15971 214 VSIVVAVFVFCWLPFYIFNVSSVSVSISPTPGLKGMFDFVVVLSYANSCANPILYAFLSDNFKKSF 279
 
Name Accession Description Interval E-value
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
1-226 8.53e-138

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 389.20  E-value: 8.53e-138
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd15971  55 FLAIQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPI 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLRSnQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRM 160
Cdd:cd15971 135 MIYAGVQT-KHGRSSCTIIWPGESSAWYTGFIIYTFILGFFVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRM 213
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 161 VSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15971 214 VSIVVAVFVFCWLPFYIFNVSSVSVSISPTPGLKGMFDFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
1-215 5.30e-51

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 167.86  E-value: 5.30e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991     1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:pfam00001  41 WLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPP 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991    81 MIYAGLR-SNQWGRSSCTINWPGESGAWYTgFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTR 159
Cdd:pfam00001 121 LLFGWTLtVPEGNVTVCFIDFPEDLSKPVS-YTLLISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSSERTQRRRKALK 199
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991   160 MVSIVVAVFIFCWLPFYIFN-VSSVSMAISPTPALKGMFDFVVVLTYANSCANPILY 215
Cdd:pfam00001 200 TLAVVVVVFILCWLPYHIVNlLDSLALDCELSRLLDKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
11-240 1.83e-23

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 97.16  E-value: 1.83e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:PHA03087 104 WSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDH 183
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   91 wGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIrvgsskrKKSEKKVTRMVSIVVAVFIF 170
Cdd:PHA03087 184 -ETLICCMFYNNKTMNWKLFINFEINIIGMLIPLTILLYCYSKILITLKGINK-------SKKNKKAIKLVLIIVILFVI 255
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991  171 CWLPFYIfNVSSVSMAISPTPALKGMFDFVVVLTYA-------NSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDD 240
Cdd:PHA03087 256 FWLPFNV-SVFVYSLHILHFKSGCKAVKYIQYALHVteiislsHCCINPLIYAFVSEFFNKHKKKSLKLMFTSSGKS 331
 
Name Accession Description Interval E-value
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
1-226 8.53e-138

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 389.20  E-value: 8.53e-138
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd15971  55 FLAIQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPI 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLRSnQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRM 160
Cdd:cd15971 135 MIYAGVQT-KHGRSSCTIIWPGESSAWYTGFIIYTFILGFFVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRM 213
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 161 VSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15971 214 VSIVVAVFVFCWLPFYIFNVSSVSVSISPTPGLKGMFDFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
1-226 9.40e-127

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 361.39  E-value: 9.40e-127
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd15093  55 FLAASNALRHWPFGSVLCRLVLSVDGINMFTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPV 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRM 160
Cdd:cd15093 135 VVFAGTRENQDGSSACNMQWPEPAAAWSAGFIIYTFVLGFLLPLLIICLCYLLIVIKVKSAGLRAGWQQRKRSERKVTRM 214
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 161 VSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15093 215 VVMVVVVFVICWLPFYVLQLVNVFVQLPETPALVGVYHFVVILSYANSCANPILYGFLSDNFKKSF 280
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
1-226 6.27e-99

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 290.93  E-value: 6.27e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd15974  55 FLATQNAISYWPFGSFLCRLVMTVDGVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPV 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLrsnQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRM 160
Cdd:cd15974 135 IIFSDV---QPDLNTCNISWPEPVSVWSTAFIIYTAVLGFFGPLLVICLCYLLIVIKVKSSGLRVGSTKRRKSERKVTRM 211
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 161 VSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15974 212 VVIIVVVFVFCWLPFYMLNIVNLIVILPEEPAFVGVYFFVVVLSYANSCANPILYGFLSDNFKQSF 277
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
1-226 3.50e-92

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 273.60  E-value: 3.50e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd15972  55 FLAAQNALSYWPFGSFMCRLVMTVDAINQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPV 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLRSnqwGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEK--KVT 158
Cdd:cd15972 135 VIFSGVPG---GMGTCHIAWPEPAQVWRAGFIIYTATLGFFCPLLVICLCYLLIVVKVRSSGRRVRATSTKRRGSerKVT 211
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12652991 159 RMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15972 212 RMVVIVVAAFVLCWLPFYALNIVNLVCPLPEEPSLFGLYFFVVVLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
1-226 4.47e-91

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 271.09  E-value: 4.47e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd14970  55 FLATSYLLGYWPFGEVMCKIVLSVDAYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPV 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKK--VT 158
Cdd:cd14970 135 IIFARTLQEEGGTISCNLQWPDPPDYWGRVFTIYTFVLGFAVPLLVITVCYSLIIRRLRSSRNLSTSGAREKRRARrkVT 214
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12652991 159 RMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd14970 215 RLVLVVVAVFVVCWLPFHVFQIVRLLIDPPETLTVVGVFLFCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
1-226 4.63e-79

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 240.14  E-value: 4.63e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd15973  55 FLAASAALQHWPFGSAMCRTVLSVDGINMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPI 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLRSNQWGRSSCTINWPGESgaWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRM 160
Cdd:cd15973 135 IIFADTATRKGQAVACNLIWPHPA--WSAAFVIYTFLLGFLLPVLAIGLCYILIIGKMRAVALKAGWQQRRKSEKKITRM 212
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 161 VSIVVAVFIFCWLPFYIFNVSSVSMaisptPALKGMFD-FVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15973 213 VLMVVTVFVICWMPFYVVQLLNLFL-----PRLDATVNhASLILSYANSCANPILYGFLSDNFRRSF 274
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
1-226 2.73e-74

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 227.87  E-value: 2.73e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd15970  55 FLVTSTLLRHWPFGSLLCRLVLSVDAINMFTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPI 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRM 160
Cdd:cd15970 135 IIFSNTAPNSDGSVACNMQMPEPSQRWLAVFVVYTFLMGFLLPVIAICLCYILIIVKMRVVALKAGWQQRKRSERKITLM 214
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 161 VSIVVAVFIFCWLPFYIFNVSSVSMAISPTPalkgMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15970 215 VMMVVTVFVICWMPFYVVQLVSVFVGQHDAT----VSQLSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
1-226 1.39e-61

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 195.77  E-value: 1.39e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd15094  55 FLIVTMILKYWPFGAAMCKIYMVLTSINQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPI 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLRSNQwGRSSCTINWP-GESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTR 159
Cdd:cd15094 135 ILYASTVPDS-GRYSCTIVWPdSSAVNGQKAFTLYTFLLGFAIPLLLISVFYTLVILRLRTVGPKNKSKEKRRSHRKVTR 213
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 160 MVSIVVAVFIFCWLPFYIFNVSSVSM--AISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15094 214 LVLTVISVYIICWLPYWAFQVHLIFLppGTDMPKWEILMFLLLTVLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
8-226 4.98e-57

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 184.17  E-value: 4.98e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   8 LVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAK--WRRPRTAKMITMAVWGVSLLVILPIMIYAG 85
Cdd:cd15087  62 LQQWPFGELLCKLILSIDHYNIFSSIYFLTVMSVDRYLVVLATVRSRRmpYRTYRAAKIVSLCVWLLVTIIVLPFTVFAG 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  86 LRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVV 165
Cdd:cd15087 142 VYSNELGRKSCVLSFPSPESLWFKASRIYTLVLGFAIPVSTICILYTMMLYKLRNMRLNSNAKALDKAKKKVTLMVLVVL 221
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 166 AVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15087 222 AVCLFCWTPFHLSTVVALTTDLPQTPLVIGISYFITSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
1-224 7.75e-57

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 183.42  E-value: 7.75e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVAL-VHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILP 79
Cdd:cd15088  55 FLIHQFAIdGQWYFGEVMCKIITALDANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILP 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  80 IMIYAGLRSNQWGRSSCTINWP-GESGAWYTgfiIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVT 158
Cdd:cd15088 135 VWVYSSLIYFPDGTTFCYVSLPsPDDLYWFT---IYHFILGFAVPLVVITVCYILILHRLARGVAPGNQSHGSSRTKRVT 211
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 159 RMVSIVVAVFIFCWLPFYIFNVSSVSMAiSPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15088 212 KMVILIVVVFIVCWLPFHVVQLVNLAMN-RPTLAFEVAYFLSICLGYANSCLNPFVYILVSENFRK 276
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
11-226 4.74e-51

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 168.63  E-value: 4.74e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd15090  65 WPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQ 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 wGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIF 170
Cdd:cd15090 145 -GSIDCTLTFSHPSWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIV 223
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 171 CWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15090 224 CWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 279
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
1-215 5.30e-51

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 167.86  E-value: 5.30e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991     1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:pfam00001  41 WLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPP 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991    81 MIYAGLR-SNQWGRSSCTINWPGESGAWYTgFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTR 159
Cdd:pfam00001 121 LLFGWTLtVPEGNVTVCFIDFPEDLSKPVS-YTLLISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSSERTQRRRKALK 199
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991   160 MVSIVVAVFIFCWLPFYIFN-VSSVSMAISPTPALKGMFDFVVVLTYANSCANPILY 215
Cdd:pfam00001 200 TLAVVVVVFILCWLPYHIVNlLDSLALDCELSRLLDKALSVTLWLAYVNSCLNPIIY 256
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
11-226 1.09e-50

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 167.82  E-value: 1.09e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd15089  65 WPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKTPR 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIF 170
Cdd:cd15089 145 DGAVVCMLQFPSPSWYWDTVTKICVFIFAFVVPILVITVCYGLMILRLRSVRLLSGSKEKDRNLRRITRMVLVVVAAFII 224
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 171 CWLPFYIFNVSSVSMAISP-TPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15089 225 CWTPIHIFVIVWTLVDIDRrNPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 281
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
11-226 1.28e-48

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 162.43  E-value: 1.28e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd15091  65 WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVRE 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 -WGRSSCTINWPGESGAWYTGFI-IYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVF 168
Cdd:cd15091 145 dVDSTECSLQFPDDDYSWWDTFMkICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVF 224
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 12652991 169 IFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15091 225 VVCWTPIHIFILVEALGSVSHSTAAVSSYYFCIALGYTNSSLNPILYAFLDENFKRCF 282
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
1-226 2.46e-46

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 156.67  E-value: 2.46e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVM-----TVdginQFTSIfCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLL 75
Cdd:cd15095  56 FTAALYATPSWVFGDFMCKFVNymmqvTV----QATCL-TLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFL 130
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  76 VILPIMIYAGLRSNQWG--RSSCTINWPgeSGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGI------RVGS 147
Cdd:cd15095 131 LSIPVAIYYRLEEGYWYgpQTYCREVWP--SKAFQKAYMIYTVLLTYVIPLAIIAVCYGLILRRLWRRSVdgnnqsEQLS 208
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 148 SKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNV-SSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15095 209 ERALRQKRKVTRMVIVVVVLFAICWLPNHVLNLwQRFDPNFPETYATYALKIAALCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
1-226 5.33e-46

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 155.41  E-value: 5.33e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd15092  55 FQGTDIFLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPV 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYaGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRM 160
Cdd:cd15092 135 MVM-GSAQVEDEEIECLVEIPTPQDYWDPVFGICVFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSKEKDRNLRRITRL 213
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 161 VSIVVAVFIFCWLPFYIFnVSSVSMAISPTPALK-GMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15092 214 VLVVVAVFVGCWTPIQIF-VLAQGLGVQPSSETAvAILRFCTALGYVNSSLNPVLYAFLDENFKACF 279
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
1-219 6.10e-44

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 150.13  E-value: 6.10e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd00637  54 FSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPP 133
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLRSNQWGRSSCTINWPGESGAWYTgfiIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKK---- 156
Cdd:cd00637 134 LLGWGVYDYGGYCCCCLCWPDLTLSKAYT---IFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRrrrr 210
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 157 ---VTRMVSIVVAVFIFCWLPFYIFNVSSVSmAISPTPALKGMFDFVVVLTYANSCANPILYAFLS 219
Cdd:cd00637 211 erkVTKTLLIVVVVFLLCWLPYFILLLLDVF-GPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
11-226 9.97e-44

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 149.58  E-value: 9.97e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd15338  69 WHFGETMCTLITALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMYAGLMPLP 148
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTINWPGESGAWYTgFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIF 170
Cdd:cd15338 149 DGSVGCALLLPNPETDTYW-FTLYQFFLAFALPLVVICVVYFKILQNMASTVAPLPQRSLRVRTKKVTRMAVAICLAFFI 227
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 171 CWLPFYIFNVSSVSMAiSPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15338 228 CWAPFYILQLAHLSID-RPSLAFLYAYNVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
1-226 1.37e-42

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 146.84  E-value: 1.37e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd14971  56 FTATIYPLPGWVFGDFMCKFVHYFQQVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPV 135
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLRSNQWG-RSSCTINWPgeSGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIR-VGSSKRKKSEKKVT 158
Cdd:cd14971 136 LALHRLRNYTPGnRTVCSEAWP--SRAHRRAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRpVLSEGSRRAKRKVT 213
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12652991 159 RMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd14971 214 RLVLVVVVLFAACWGPIHAILLLVALGPFPLTYATYALRIWAHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
1-226 3.78e-41

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 143.20  E-value: 3.78e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd15096  56 FTATDYVLPTWPFGDVWCKIVQYLVYVTAYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPV 135
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLRSNQW---GRSSCTINWPGESGAwyTGFIIYTFILGFLVPLTIICLCYLFIIIKV---KSSGIRVgSSKRKKSE 154
Cdd:cd15096 136 LFLHGVVSYGFsseAYSYCTFLTEVGTAA--QTFFTSFFLFSYLIPLTLICVLYMLMLRRLrrqKSPGGRR-SAESQRGK 212
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12652991 155 KKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15096 213 RRVTRLVVVVVVVFAICWLPIHIILLLKYYGVLPETVLYVVIQILSNCLAYGNSCVNPILYAFLSQNFRKAF 284
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
1-226 9.68e-41

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 141.16  E-value: 9.68e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILP 79
Cdd:cd14967  55 FSAVYTLLGYWPFGPVLCRFWIALDVLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLIsLPP 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  80 IMiyagLRSNQWGRSSCTINWPGESGAWYtgfIIYTFILGFLVPLTIICLCYlFIIIKVKSSGIRvgsskrkksekkVTR 159
Cdd:cd14967 135 LV----GWRDETQPSVVDCECEFTPNKIY---VLVSSVISFFIPLLIMIVLY-ARIFRVARRELK------------AAK 194
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 160 MVSIVVAVFIFCWLPFYIFNVssVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd14967 195 TLAIIVGAFLLCWLPFFIIYL--VSAFCPPDCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
1-226 1.96e-40

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 141.02  E-value: 1.96e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd15098  58 FQATIYSLPEWVFGAFMCKFVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPV 137
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLRSNQWGRSS--CTINWPgeSGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgIRVGSSKRKKSEKKVT 158
Cdd:cd15098 138 AVHQDLVHHWTASNQtfCWENWP--EKQQKPVYVVCTFVFGYLLPLLLITFCYAKVLNHLHKK-LKNMSKKSERSKKKTA 214
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 159 RMVSIVVAVFIFCWLPFYIfnvssVSMAIS--PTPALKGMFDFVVV---LTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15098 215 QTVLVVVVVFGISWLPHHI-----IHLWVEfgDFPLTQASFVLRITahcLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
10-226 8.81e-40

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 139.32  E-value: 8.81e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd14982  65 WWPFGDFLCRLTGLLFYINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAK 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINWPgESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRvgsSKRKKSEKKVTRMVSIVVAVFI 169
Cdd:cd14982 145 ENNSTTCFEFLS-EWLASAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQ---SQKSVRKRKALRMILIVLAVFL 220
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 170 FCWLPFYIFNV------SSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd14982 221 VCFLPYHVTRIlyllvrLSFIADCSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
11-226 2.71e-39

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 138.50  E-value: 2.71e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd14993  66 WVFGEVLCKAVPYLQGVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEII 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 W------GRSSCTINWPGESGAWYtgFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKK-------- 156
Cdd:cd14993 146 SsepgtiTIYICTEDWPSPELRKA--YNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSSRrilrskkk 223
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 157 VTRMVSIVVAVFIFCWLPFYIFNVSSV---SMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd14993 224 VARMLIVVVVLFALSWLPYYVLSILLDfgpLSSEESDENFLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
7-226 6.92e-39

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 136.96  E-value: 6.92e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   7 ALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGL 86
Cdd:cd14984  60 AADGWVFGSFLCKLVSALYTINFYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQV 139
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  87 rSNQWGRSSCTINWPGESGA-WYTGFIIYTFILGFLVPLTIICLCYLFIIIK-VKSSGIRVGSSKrkksekkvtRMVSIV 164
Cdd:cd14984 140 -SEENGSSICSYDYPEDTATtWKTLLRLLQNILGFLLPLLVMLFCYSRIIRTlLRARNHKKHRAL---------RVIFAV 209
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 165 VAVFIFCWLPFYIFN-VSSVSM--AISPTPALKGMFDFVV----VLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd14984 210 VVVFFLCWLPYNIVLlLDTLQLlgIISRSCELSKSLDYALqvteSLAFSHCCLNPVLYAFVGVKFRKYL 278
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
11-226 1.13e-38

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 136.74  E-value: 1.13e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd14985  66 WPFGAFLCKVSSYVISVNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQAIE 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 W-GRSSCTINWPGEsgAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGssKRKKSEKKVTRMVSIVVAVFI 169
Cdd:cd14985 146 NlNKTACIMLYPHE--AWHFGLSLELNILGFVLPLLIILTCYFHIARSLRKRYERTG--KNGRKRRKSLKIIFALVVAFL 221
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 170 FCWLPFYIF---NVSSVSMAISPTP---ALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd14985 222 VCWLPFHFFkflDFLAQLGAIRPCFwelFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
1-226 5.18e-37

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 132.04  E-value: 5.18e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVAL-VHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILP 79
Cdd:cd14974  54 FLIVYIAMgHHWPFGSVLCKLNSFVISLNMFASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVP 133
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  80 IMIYAGLRSNQWGRSS---CTINWPGESGAWYTGFIIyTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRkksekk 156
Cdd:cd14974 134 YFVFRDTVTHHNGRSCnltCVEDYDLRRSRHKALTVI-RFLCGFLLPLLIIAICYSVIAVKLRRKRLAKSSKPL------ 206
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 157 vtRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd14974 207 --RVLLAVVVAFFLCWLPYHVFALLELVAAAGLPEVVLLGLPLATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
10-224 7.90e-37

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 131.86  E-value: 7.90e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd15339  64 EWVFGSPLCTIITSLDTCNQFACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKF 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINWPG-ESGAWYTgfiIYTFILGFLVPLTIICLCYLFII------IKVKSSGIRVGSSKRKKSEKKVTRMVS 162
Cdd:cd15339 144 RDGLESCAFNLTSpDDVLWYT---LYQTITTFFFPLPLILICYILILcytwemYRKNKKAGRYNTSIPRQRVMRLTKMVL 220
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12652991 163 IVVAVFIFCWLPFYIFNVSSVSMAiSPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15339 221 VLVGVFLVSAAPYHVIQLVNLSVS-QPTLAFYVSYYLSICLSYASSSINPFLYILLSGNFRK 281
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
1-226 1.96e-36

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 131.09  E-value: 1.96e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVAL-VHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILP 79
Cdd:cd14976  57 FWAVEYALdFVWPFGTAMCKVVRYVTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIP 136
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  80 IMIYAGLRSNQWGRSSCTINWPGESGA--WYTGFIIYTF---ILGFLVPLTIICLCYLFIIIKVKSSGIRvgsskRKKSE 154
Cdd:cd14976 137 EAIFSTDTWSSVNHTLCLLRFPKNSSVtrWYNWLGMYQLqkvVLGFFLPLGIITLSYLLLLRFLQRKRGG-----SKRRK 211
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 155 KKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTP-------ALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd14976 212 SRVTKSVFIVVLSFFICWLPNQALSLWSALIKFDDVPfsdaffaFQTYAFPVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
11-224 5.34e-35

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 127.17  E-value: 5.34e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKwRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd14999  64 WYFGDVGCRLLFSLDFLTMHASIFTLTVMSTERYLAVVKPLDTVK-RSKSYRKLLAGVIWLLSLLLTLPMAIMIRLVTVE 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 ---WGRSSCTINWPGESGawYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKK-VTRMVSIVVA 166
Cdd:cd14999 143 dksGGSKRICLPTWSEES--YKVYLTLLFSTSIVIPGLVIGYLYIRLARKYWLSQAAASNSSRKRLPKQkVLKMIFTIVL 220
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 167 VFIFCWLPFYIFNVSSV-SMAISPTPALKGMFDFVVV-LTYANSCANPILYAFLSDNFKK 224
Cdd:cd14999 221 VFWACFLPFWIWQLLYLySPSLSLSPRTTTYVNYLLTcLTYSNSCINPFLYTLLTKNYKE 280
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
10-226 1.23e-34

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 126.18  E-value: 1.23e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAkwRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd15203  65 NWPFGSILCKLVPSLQGVSIFVSTLTLTAIAIDRYQLIVYPTRPR--MSKRHALLIIALIWILSLLLSLPLAIFQELSDV 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSS-----CTINWPGESGAwyTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKK-------- 156
Cdd:cd15203 143 PIEILPycgyfCTESWPSSSSR--LIYTISVLVLQFVIPLLIISFCYFRISLKLRKRVKKKRGKRTLSSRRRrselrrkr 220
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12652991 157 -VTRMVSIVVAVFIFCWLPFYIFNV----SSVSMAISPTPALKGMFDFVVVLTyaNSCANPILYAFLSDNFKKSF 226
Cdd:cd15203 221 rTNRLLIAMVVVFAVCWLPLNLFNLlrdfEPLPQIDGRHFYLIFLICHLIAMS--SACVNPLLYGWLNDNFRKEF 293
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
10-224 7.22e-34

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 124.49  E-value: 7.22e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIY--AGLR 87
Cdd:cd15190  76 HWPFGSFLCKLSSYLVFVNMYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALILrtTSDL 155
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  88 SNQWgRSSCTINWPG-----ESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVkSSGIRVGSSKRKKSEKKVTRMVS 162
Cdd:cd15190 156 EGTN-KVICDMDYSGvvsneSEWAWIAGLGLSSTVLGFLLPFLIMLTCYFFIGRTV-ARHFSKLRRKEDKKKRRLLKIII 233
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 163 IVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVV-------LTYANSCANPILYAFLSDNFKK 224
Cdd:cd15190 234 TLVVTFALCWLPFHLVKTLYALMYLGILPFSCGFDLFLMNahpyatcLAYVNSCLNPFLYAFFDPRFRQ 302
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
10-226 1.32e-33

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 123.31  E-value: 1.32e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRS- 88
Cdd:cd15192  65 HWPFGNFLCKIASALVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDVFFi 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirVGSSKRKKSEKKVTRMVSIVVAVF 168
Cdd:cd15192 145 ENTNITVCAFHYPSQNSTLLVGLGLMKNLLGFLIPFLIILTCYTLIGKALKKA---YEIQRNKPRNDEIFKMIMAVVLFF 221
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12652991 169 IFCWLPFYIFNVSSV--SMAISPTPALKGMFD----FVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15192 222 FFCWIPHQIFTFLDVliQLKVIQDCHIADIVDtampFTICIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
10-224 1.53e-33

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 123.34  E-value: 1.53e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRS- 88
Cdd:cd15381  65 NWPFGEFLCKSVNAVIYMNLYSSIYFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVFRTVMYf 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRSSCTINWPGESgaWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRvgSSKRKKSEKKVTRMVSIVVAVF 168
Cdd:cd15381 145 PEYNITACVLDYPSEG--WHVALNILLNVVGFLIPLSIITFCSTQIIQVLRNNKMQ--KFKEIQTERKATVLVLAVLLMF 220
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12652991 169 IFCWLPFYIFNVSSV--SMAISPTPALKGMFDFVVVLT----YANSCANPILYAFLSDNFKK 224
Cdd:cd15381 221 FICWLPFHIFTFLDTlhKLGLISGCRWEDILDIGTQIAtflaYSNSCLNPLLYVIVGKHFRK 282
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
10-222 1.53e-32

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 120.50  E-value: 1.53e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLrSN 89
Cdd:cd15168  65 HWIFGDFMCKLVRFLFYFNLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFATT-GR 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirVGSSKRKKSEKKVTRMVSIVVAVFI 169
Cdd:cd15168 144 KNNRTTCYDTTSPEELNDYVIYSMVLTGLGFLLPLLIILACYGLIVRALIRK---LGEGVTSALRRKSIRLVIIVLALFA 220
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 170 FCWLPFYIFNVSSVSMAISPTPALKGMFDFVVV-------LTYANSCANPILYAFLSDNF 222
Cdd:cd15168 221 VCFLPFHVTRTINLAARLLSGTASCATLNGIYVaykvtrpLASLNSCLNPLLYFLAGDKF 280
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
11-226 1.61e-32

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 120.63  E-value: 1.61e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKwRRPRTAKMITMAVWGVSLLVILPIMIYAGLRS-N 89
Cdd:cd15191  66 WLFGSVMCKICGSLLTLNLFASIFFITCMSVDRYLAVVYPLRSQR-RRSWQARLVCLLVWVLACLSSLPTFYFRDTYYiE 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINWPGESGA-WYTGFIIYTFILGFLVPLTIICLCYLFI---IIKVKSSGIRVGsskrkkSEKKVTRMVSIVV 165
Cdd:cd15191 145 ELGVNACIMAFPNEKYAqWSAGLALMKNTLGFLIPLIVIATCYFGIgrhLLKTKGFGKNKQ------RRDKVLKMVAAVV 218
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 166 AVFIFCWLPFYI--FNVSSVSMAISPTPALKGMFD----FVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15191 219 LAFLICWFPFHVltFLDALARMGVINNCWVITVIDkalpFAICLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
10-226 6.11e-32

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 119.10  E-value: 6.11e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd15116  64 HWPFGRFMCKLNSFLLFLNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPS 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRS-SCTINW----PGESGAWY-------TGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirvgsskRKKSEKKV 157
Cdd:cd15116 144 QNNNKiICFNNFslsgDNSSPEVNqlrnmrhQVMTITRFLLGFLIPFTIIICCYAAIVLKLKRN--------RLAKSSKP 215
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 158 TRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15116 216 FKIIAAVIVTFFLCWAPYHILNLLEMEATRSPASVFKIGLPITSSLAFINSCLNPILYVFMGQDFKKFK 284
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
8-226 1.70e-31

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 118.11  E-value: 1.70e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   8 LVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSaKWRRPRTAKMITmAVWGVSLLVILPIMIYAGLR 87
Cdd:cd15207  63 LTGWPFGDVMCKLSPLVQGVSVAASVFTLVAIAVDRYRAVVHPTEP-KLTNRQAFVIIV-AIWVLALAIMIPQALVLEVK 140
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  88 SNQWGR----SSCTINWPGESG-AWYTGFIiytFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKK------ 156
Cdd:cd15207 141 EYQFFRgqtvHICVEFWPSDEYrKAYTTSL---FVLCYVAPLLIIAVLYVRIGYRLWFKPVPGGGSASREAQAAvskkkv 217
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12652991 157 -VTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPT---PALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15207 218 rVIKMLIVVVVLFALSWLPLHTVTMLDDFGNLSPNqreVLYVYIYPIAHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
10-224 6.93e-31

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 115.64  E-value: 6.93e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd15115  64 HWPYGRFLCKLLPSIIVLNMFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTVTD 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QwGRSSCTINwpgesgaWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRvgsskrkKSEKKVTRMVSIVVAVFI 169
Cdd:cd15115 144 G-NHTRCGYD-------FLVAITITRAVFGFLLPLLIIAACYSFIAFRMQRGRFA-------KSQSKTFRVIIAVVVAFF 208
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12652991 170 FCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15115 209 VCWAPYHIIGILSLYGDPPLSKVLMSWDHLSIALAYANSCLNPVLYVFMGKDFKK 263
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
1-223 3.37e-30

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 114.07  E-value: 3.37e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALV----HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV 76
Cdd:cd15119  51 FLPLHITYValdfHWPFGVWLCKINSFVAVLNMFASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAI 130
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  77 ILPIMIYAGLRSNQWGRSSCTINWPGESG----AWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIrvgsskrkK 152
Cdd:cd15119 131 SGPALYFRDTMELSINVTICFNNFHKHDGdlivMRHTILVWVRFFFGFLFPLLTMVVCYSLLAIKVKRRTL--------L 202
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 153 SEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPT--PALKGMFDFVVVLTYANSCANPILYAFLSDNFK 223
Cdd:cd15119 203 ISSKFFWTISAVIVAFFVCWTPYHIFSILELSIHHSSYlhNVLRAGIPLATSLAFINSCLNPILYVLIGKKFK 275
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
11-224 4.46e-30

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 114.10  E-value: 4.46e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRS-N 89
Cdd:cd15189  66 WPFGELLCRVVNGVIKVNLYTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAiP 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINWPgeSGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgiRVGSSKRKKSEKKVTRMVSIVVAVFI 169
Cdd:cd15189 146 DLNITACVLLYP--HEAWHFAHIVLLNIVGFLLPLLVITFCNYNILQALRTR--EESTRCEDRNDSKATALVLAVTLLFL 221
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12652991 170 FCWLPFYIFNVSSVsmaISPTPALKGMFD---------FVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15189 222 VCWGPYHFFTFLDF---LFDVGVLDECFWehfidiglqLAVFLAFSNSCLNPVLYVFVGRYFRR 282
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
10-226 8.12e-30

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 112.75  E-value: 8.12e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd15001  64 TWSLGAFLCKAVAYLQLLSFICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRY 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGR----SSCTINWPgeSGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKvkssgirvgsskrkksekKVTRMVSIVV 165
Cdd:cd15001 144 ESENgvtvYHCQKAWP--STLYSRLYVVYLAIVIFFIPLIVMTFAYARDTRK------------------QVIKMLISVV 203
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 166 AVFIFCWLPFYIFNVSSVSMAIS--PTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15001 204 VLFAVCWGPLLIDNLLVSFDVIStlHTQALKYMRIAFHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
1-226 7.95e-29

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 110.57  E-value: 7.95e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALV-HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILP 79
Cdd:cd15114  54 ILAVPIAQDgHWPFGAAACKLLPSLILLNMYASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVP 133
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  80 IMIYAGLRSNQW-GRSSCTINWPGESGAWYTGFIIyTFILGFLVPLTIICLCYLFIIIKVKSSgirvgsskRKKSEKKVT 158
Cdd:cd15114 134 SFIYRRIHQEHFpEKTVCVVDYGGSTGVEWAVAII-RFLLGFLGPLVVIASCHGVLLVRTWSR--------RRQKSRRTL 204
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 159 RMVSIVVAVFIFCWLPFYIFNVS-SVSMAISPTPALKGMFDFVVV-LTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15114 205 KVVTAVVVGFFLCWTPYHVVGLIiAASAPNSRLLANALKADPLTVsLAYINSCLNPIIYVVAGRGFRKSL 274
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
1-226 9.75e-29

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 110.28  E-value: 9.75e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQValvhWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd15122  61 FLTRKT----WPFGQAVCKAVYYLCCLSMYASIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPA 136
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLRSNQWGRSSCTINW---PGESGAWYTgfiiYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGsskrkkseKKV 157
Cdd:cd15122 137 FVYRHVWKDEGMNDRICEPChasRGHAIFHYT----FETLVAFVLPFGVILFSYSVILVRLKGARFRRR--------ARV 204
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 158 TRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDF-------VVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15122 205 EKLIAAIVVAFALLWVPYHVVNLLQVVANLAPGEVLEKLGGAakaaragATALAFFSSSVNPLLYVFAAGDLIKTS 280
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
1-226 9.97e-29

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 110.59  E-value: 9.97e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVAL-VHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILP 79
Cdd:cd15117  54 FSVVYTALgFHWPFGWFLCKLYSTLVVFNLFASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGP 133
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  80 IMIYAGLRSNQwGRSSCTIN---WPGESGAW----------YTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIrvg 146
Cdd:cd15117 134 HLVFRDTRKEN-GCTHCYLNfdpWNETAEDPvlwletvvqrLSAQVITRFVLGFLVPLVIIGGCYGLIAARLWREGW--- 209
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 147 sskrkKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVV----VLTYANSCANPILYAFLSDNF 222
Cdd:cd15117 210 -----VHSSRPFRVLTAVVAAFFLCWFPFHLVSLLELVVILNQKEDLNPLLILLLplssSLACVNSCLNPLLYVFVGRDF 284

                ....
gi 12652991 223 KKSF 226
Cdd:cd15117 285 RERL 288
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
10-226 3.32e-28

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 109.10  E-value: 3.32e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd15120  64 HWAFGTVLCKVLNSTLSVGMFTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPYLAFRETRLD 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINW----------PGESGAW-YTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIrvgsskrkKSEKKVT 158
Cdd:cd15120 144 EKGKTICQNNYalstnwesaeVQASRQWiHVAMFVFRFLLGFLLPFLIITFCYVRMALKMKERGL--------ARSSKPF 215
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12652991 159 RMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPaLKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15120 216 KVMFTAVVSFFVCWLPYHLHSGLVLTRGRPPSL-TDITLLLTVGTTCFNTCFTPVLYLFVGENFKKVL 282
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
5-226 1.25e-27

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 107.90  E-value: 1.25e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   5 QVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYA 84
Cdd:cd14992  60 YVVSLSWEYGHFLCKIVNYLRTVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYA 139
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  85 GL-----RSNQWGRSSCTINWPGeSGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKV---KSSGIRVGSSKRKKSEKK 156
Cdd:cd14992 140 TTevlfsVKNQEKIFCCQIPPVD-NKTYEKVYFLLIFVVIFVLPLIVMTLAYARISRELwfrKVPGFSIKEVERKRLKCK 218
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 157 --VTRMVSIVVAVFIFCWLPFYIFN-VSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd14992 219 rrVIKMLVCVVVLFVICWLPFHLFFlLRDFFPLIMKEKHTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
1-226 1.35e-27

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 107.50  E-value: 1.35e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKsAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd15002  57 FRAAAYSKGSWPLGWFVCKTADWFGHACMAAKSFTIAVLAKACYMYVVNPTK-QVTIKQRRITAVVASIWVPACLLPLPQ 135
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLRSnQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRM 160
Cdd:cd15002 136 WLFRTVKQ-SEGVYLCILCIPPLAHEFMSAFVKLYPLFVFCLPLTFALFYFWRAYGQCQRRGTKTQNLRNQIRSRKLTHM 214
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 161 VSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15002 215 LLSVVLAFTILWLPEWVAWLWLIHIKSSGSSPPQLFNVLAQLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
10-226 1.35e-27

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 107.36  E-value: 1.35e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTaKMITMAVWGVSLLVILPIMIYAG-LRS 88
Cdd:cd15178  63 GWIFGTFMCKLVSLLQEANFYSGILLLACISVDRYLAIVHATRALTQKRHLV-KFVCAGVWLLSLLLSLPALLNRDaFKP 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRSSCTINWPGESGA-WYTGFIIYTFILGFLVPLTIICLCYLFIIIKV-------KSSGIRVgsskrkksekkvtrm 160
Cdd:cd15178 142 PNSGRTVCYENLGNESADkWRVVLRILRHTLGFLLPLVVMLFCYGFTIKTLlqtrsfqKHRAMRV--------------- 206
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 161 VSIVVAVFIFCWLPFYIFNVSSVSM---AISPTPALKGMFDFVV----VLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15178 207 IFAVVLAFLLCWLPYNVTVLIDTLMrtkLITETCELRNHVDVALyvtqILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
11-225 1.65e-27

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 107.21  E-value: 1.65e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYaglRSNQ 90
Cdd:cd15121  65 WEFGSVVCKLCHYVCGVSMYASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMPFY---RTVL 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTINWPGESGAWYTGF-IIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRvgsskrkkSEKKVTRMVSIVVAVFI 169
Cdd:cd15121 142 KKNINMKLCIPYHPSVGHEAFqYLFETITGFLLPFTAIVTCYSTIGRRLRSARFR--------RKRRTNRLVVLIIATFA 213
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 170 FCWLPFYIFNVSSVSMAISPTPALKGMF-------DFVVVLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15121 214 LFWLPYHVVNLIQVAGALQNQAGNASVLkaaklarPNVTALAFLSSSVNPVLYAFAGGSLIRS 276
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
1-226 3.19e-27

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 106.52  E-value: 3.19e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVAL-VHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILP 79
Cdd:cd15926  56 FWAVENALdFTWLFGKAMCKIVSYVTAMNMYASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLP 135
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  80 IMIYAgLRSNQWGRSSCTINWPGESGA---WYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIrvgSSKRKKSEKK 156
Cdd:cd15926 136 NAIFS-TTATVSNEELCLVKFPDNRGNaqfWLGLYHAQKVLLGFLIPLGIISLCYLLLVRFITDKNI---TGSSTKRRSK 211
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 157 VTRMVSIVVAVFIFCWLP---------FYIFNVSSVSMAISPTPALkgMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15926 212 VTKSVTIVVLSFFLCWLPnqalttwgiLIKLNVVHFSYEYFTTQVY--IFPITVCLAHSNSCLNPILYCLMRREFRKAL 288
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
6-226 4.38e-27

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 106.05  E-value: 4.38e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   6 VALVH--WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKsakwrrPRT----AKMITMAVWGVSLLVILP 79
Cdd:cd15202  59 VRAVNntWIFGLFMCHFSNFAQYCSVHVSAYTLTAIAVDRYQAIMHPLK------PRIsktkAKFIIAVIWTLALAFALP 132
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  80 IMIYAGL----RSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEK 155
Cdd:cd15202 133 HAICSKLetfkYSEDIVRSLCLEDWPERADLFWKYYDLALFILQYFLPLLVISFAYARVGIKLWASNMPGDATTERYFAL 212
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 156 K-----VTRMVSIVVAVFIFCWLPFYIFNV---SSVSMAISPTPALKGMFDFvvvLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15202 213 RrkkkkVIKMLMVVVVLFALCWLPFNIYVLllsSKPDYLIKTINAVYFAFHW---LAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
7-226 1.41e-26

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 104.77  E-value: 1.41e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   7 ALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGL 86
Cdd:cd15180  60 AVHGWIFGTGLCKLAGAVFKINFYCGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSIPDFIFLEA 139
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  87 RSN-QWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIK--VKSSGIRVGSSkrkksekkvTRMVSI 163
Cdd:cd15180 140 TKDpRQNKTECVHNFPQSDTYWWLALRLLYHIVGFLLPLAVMVYCYTSILLRllRSSQGFQKQRA---------IRVIVA 210
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 164 VVAVFIFCWLPFYIFNVSSVSMAISPTPALKGM---FDFVVVLT----YANSCANPILYAFLSDNFKKSF 226
Cdd:cd15180 211 VVVVFFLCWTPYNIALLVDTLIDLSVLDRNCGTesrLDIALSVTsslgYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
8-226 2.22e-26

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 104.06  E-value: 2.22e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   8 LVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLR 87
Cdd:cd15181  61 IAGWVFGTFLCKLVGAIHKLNFYCSSLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPNLVFLEVE 140
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  88 SNQWG-RSSCTINWPG--ESGAWYTGFIIYtFILGFLVPLTIICLCYLFIIIKVKSSGIRVgsskrkkSEKKVTRMVSIV 164
Cdd:cd15181 141 TSTNAnRTSCSFHQYGihESNWWLTSRFLY-HVVGFFLPLLIMGYCYATIVVTLCQSSRRL-------QKQKAIRVAILV 212
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 165 VAVFIFCWLPFYI---FNVSSVSMAISPTPALKGMFDFVVVLT----YANSCANPILYAFLSDNFKKSF 226
Cdd:cd15181 213 TLVFCLCWLPYNIvifLDTLDDLKAVVKNCKLNDLLDAAITVTeslgFSHCCLNPILYAFIGVKFRNDL 281
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
10-226 1.05e-25

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 101.92  E-value: 1.05e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAG-LRS 88
Cdd:cd15321  71 YWYFRKTWCEIYLALDVLFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGkQKD 150
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRSSCTINwpgeSGAWYtgfIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRvgsskrkksekkVTRMVSIVVAVF 168
Cdd:cd15321 151 EQGGLPQCKLN----EEAWY---ILSSSIGSFFAPCLIMILVYLRIYLIAKNREKR------------FTFVLAVVIGVF 211
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 169 IFCWLPFYI-FNVSSVSMAISPTPalKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15321 212 VLCWFPFFFsYSLGAICPELCKVP--HSLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
5-226 1.47e-25

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 102.10  E-value: 1.47e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   5 QVALVH-WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKwrRPRTAKMITMAVWGVSLLVILPIMIY 83
Cdd:cd15393  59 QAALLQrWVLPRFMCPFCPFVQVLSVNVSVFTLTVIAVDRYRAVIHPLKARC--SKKSAKIIILIIWILALLVALPVALA 136
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  84 AG-----LRSNQWGRSSCTINWPgeSGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGI-----RVGSSKRKKS 153
Cdd:cd15393 137 LRveeltDKTNNGVKPFCLPVGP--SDDWWKIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTKApgnaqDVRDDEILKN 214
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12652991 154 EKKVTRMVSIVVAVFIFCWLPFYIFNV-SSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15393 215 KKKVIKMLIIVVALFALCWLPLQTYNLlNEIKPEINKYKYINIIWFCSHWLAMSNSCYNPFIYGLYNEKFKREF 288
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
13-226 1.53e-25

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 101.70  E-value: 1.53e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  13 FGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRS-NQW 91
Cdd:cd15206  68 FGEVMCKLIPYFQAVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPmSRP 147
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  92 GRSSCTINWPGESG--AWYtgfIIYTFILgFLVPLTIICLCYLFIIIKVKSSGIRvgsskrkksekkVTRMVSIVVAVFI 169
Cdd:cd15206 148 GGHKCREVWPNEIAeqAWY---VFLDLML-LVIPGLVMSVAYGLISWTLLEAKKR------------VIRMLFVIVVEFF 211
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 170 FCWLPFYIFNV------SSVSMAISPTPalkgmFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15206 212 ICWTPLYVINTwkafdpPSAARYVSSTT-----ISLIQLLAYISSCVNPITYCFMNKRFRQAF 269
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
11-223 1.87e-25

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 101.28  E-value: 1.87e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd15182  64 WIFGEILCKAVTSIFYIGFYSSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTVMKSD 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTInwpgESGAWYTGFiIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVgsskrkksEKKVTRMVSIVVAVFIF 170
Cdd:cd15182 144 EDGSLCEY----SSIKWKLGY-YYQQNLFFLIPLGIIVYCYVRILQTLMRTRTMR--------KHRTVKLIFVIVLVFFL 210
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 171 CWLPFYIfnvssVSMAISPTPALKGMFDFVVVLTYA----------NSCANPILYAFLSDNFK 223
Cdd:cd15182 211 SWAPYNI-----VIFLRSLKDLTIPICECSKQLDYAfyicrniafsHCCLNPVFYVFVGVKFR 268
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
1-226 2.53e-25

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 101.44  E-value: 2.53e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd15097  57 FQATIYSLEGWVFGSFLCKAVHFFIYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPY 136
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLrsNQWGRSscTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKV-KSSGIRVGSSKRKKSEKKVTR 159
Cdd:cd15097 137 LSYYDL--IDYANS--TVCMPGWEEARRKAMDTCTFAFGYLIPVLVVSLSYTRTIKYLwTAVDPLEAMSESKRAKRKVTK 212
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 160 MVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15097 213 MIIIVTALFCLCWLPHHVVILCYLYGDFPFNQATYAFRLLSHCMAYANSCLNPIVYALVSKHFRKGF 279
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
11-226 3.02e-25

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 100.88  E-value: 3.02e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMiyaglrsnq 90
Cdd:cd15053  67 WYLGPILCDIYIAMDVMCSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLL--------- 137
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 wgrssCTINW-----PGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirvgsskrkkseKKVTRMVSIVV 165
Cdd:cd15053 138 -----FGLNNvpyrdPEECRFYNPDFIIYSSISSFYIPCIVMLLLYYRIFRALRRE-------------KKATKTLAIVL 199
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12652991 166 AVFIFCWLPFYIFNVS-SVSMAISPTPALKG--MFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15053 200 GVFLFCWLPFFTLNILnAICPKLQNQSCHVGpaLFSLTTWLGYVNSFLNPIIYTIFNIEFRKAF 263
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
11-224 3.18e-25

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 100.98  E-value: 3.18e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNq 90
Cdd:cd15193  66 WLFGEGLCKLSSFIIAVNRCSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVYRNLINE- 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 wgrSSCtinWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKS---SGIRVGSSKRKKSekkvtRMVSIVVAV 167
Cdd:cd15193 145 ---SVC---VEDSSSRFFQGISLATLFLTFVLPLIVILFCYCSILVRLRRhfhGAKRTGRRRRNSL-----RIVFAIVTA 213
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12652991 168 FIFCWLPFYIFNVSSV---SMAISPTPALKGMFDFVVVLT----YANSCANPILYAFLSDNFKK 224
Cdd:cd15193 214 FVLSWLPFNTLKAVRLlleLGGGVLPCHTTVAIRQGLTITaclaFVNSCVNPLIYSLLDRHFRR 277
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
10-226 3.70e-25

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 100.98  E-value: 3.70e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIY-AGLRS 88
Cdd:cd15162  65 NWIFGEALCRLVTVAFYGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVkQTIFL 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRSSC--TINWPGESGAWYTGFIIYtFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEkkvtRMVSIVVA 166
Cdd:cd15162 145 PALDITTChdVLPEQLLVGDWFYYFLSL-AIVGFLIPFILTASCYVATIRTLAALEDENSEKKKKRAI----KLAATVLA 219
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 167 VFIFCWLPFYIFNVSSVS-MAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15162 220 IFIICFAPSNLLLLAHYSlISSSGTGHLYFAYLLALCLSTLNSCIDPFIYYFVSKEFRDHV 280
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
7-225 3.83e-25

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 100.61  E-value: 3.83e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   7 ALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGL 86
Cdd:cd15179  60 AAANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKV 139
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  87 rSNQWGRSSCTINWPGESGA-WYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirvgsskRKKSEKKVTRMVSIVV 165
Cdd:cd15179 140 -SELDDRYICDRIYPEDTFElWVVAFRFQHILVGLVLPGLVILTCYCIIISKLSHS--------KGHQKRKALKTTVILI 210
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 166 AVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVV-------LTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15179 211 LAFFACWLPYYIGISIDTFMLLEIIKQSCEMEQTVHKwisiteaLAFFHCCLNPILYAFLGAKFKTS 277
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
10-223 4.04e-25

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 101.03  E-value: 4.04e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRS- 88
Cdd:cd15380  65 NWPFGNFLCRVISGVIKANLFISIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRSVKHv 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRSSCTINWPGEsgAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVF 168
Cdd:cd15380 145 PDLNISACILLFPHE--AWHFARRVELNIVGFLLPLAAIVFFNFHIIASLRERTEESRKRCGGLKDTKATRLILTLVLMF 222
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12652991 169 IFCWLPFYIFNVSSVSMAISptpALKGMF---------DFVVVLTYANSCANPILYAFLSDNFK 223
Cdd:cd15380 223 LVCWTPYHFFAFLDFLFQVE---VIQGCFweefidlglQLANFFAFANSCLNPVIYVFAGKLFR 283
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
10-225 4.10e-25

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 100.63  E-value: 4.10e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd14975  64 TWDFGLAACKGCVYVCAVSMYASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVEET 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QwGRSSCTINWPgeSGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRkksekkvtRMVSIVVAVFI 169
Cdd:cd14975 144 V-ENGMCKYRHY--SDGQLVFHLLLETVVGFAVPFTAVVLCYSCLLRRLRRRRFRRRRRTG--------RLIASVVVAFA 212
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12652991 170 FCWLPFYIFNVSSVSMAISPTPALKGMFDFV--------VVLTYANSCANPILYAFLS-DNFKKS 225
Cdd:cd14975 213 ACWLPYHVGNLLEVVSELIGGSKMAGTLGKVaeagrpiaGALAFLSSSINPLLYAFAArGLFRSA 277
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
11-226 4.12e-25

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 101.19  E-value: 4.12e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd15927  66 WPFGEFLCKLSEFLKDTSIGVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVTFT 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 W----GRSSCTINwPGESGAWYTGF-IIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSE------KKVTR 159
Cdd:cd15927 146 LtdnqTIQICYPY-PQELGPNYPKImVLLRFLVYYLIPLLIIGVFYVLMARHLIRSTRNIGSGQNQAAQrqiearKKVAK 224
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 160 MVSIVVAVFIFCWLPFYIFNvssVSMAISPTPALK-GMFDFVV-----VLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15927 225 TVLAFVVLFAVCWLPRHVFM---LWFHFAPNGLVDyNAFWHVLkivgfCLSFINSCVNPVALYLLSGSFRRHF 294
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
10-226 7.22e-25

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 100.17  E-value: 7.22e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIyaglrsn 89
Cdd:cd15161  65 HWPFGEVPCRLAGFLFYLNMYASLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIVTVAMAPLLV------- 137
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 qwGRSSCTINWPGESGAWY----TGFIIYTFILGFLVPLTIICLCYLFIIIKVKSsgirvGSSKRKKSEKKVTRMVSIVV 165
Cdd:cd15161 138 --SPQTVEVNNTTVCLQLYrekaSRGALVSLAVAFTIPFVTTVTCYLLIIRSLRT-----GKREEKPLKDKAIKMIILVL 210
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 166 AVFIFCWLP------FYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15161 211 TIFLICFVPyhisryIYILSHNGAGASCSSRRGLALANRITSCLTCLNGALDPVMYFFVAEKFRETL 277
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
5-224 1.37e-24

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 99.10  E-value: 1.37e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   5 QVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYA 84
Cdd:cd15187  58 YYLLDQWVFGNAMCKIVSGAYYIGFYSSMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVFY 137
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  85 GLRSNQwGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirvgsskRKKSEKKVTRMVSIV 164
Cdd:cd15187 138 QVASED-GRLQCIPFYPGQGNSWKVFTNFEVNILGLLIPFSILIFCYHNILRNLRRC--------HNQNKTKAIKLVFIV 208
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 165 VAVFIFCWLPFYI--FNVSSVSMAISPTPALKGMFDFVV----VLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15187 209 VIVFFLFWTPFNVvlFLDSLHSLHIIDGCQNSQRLTLALhlteTISFTHCCLNPVIYAFVGEKFKK 274
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
2-226 1.39e-24

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 98.95  E-value: 1.39e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   2 LAMQVALV-----HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV 76
Cdd:cd15059  52 LIMPFSLVnelmgYWYFGSVWCEIWLALDVLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVI 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  77 IL-PIMIYAGLRSNQWGRSSCTINwpgeSGAWYtgfIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRvgsskrkksek 155
Cdd:cd15059 132 SLpPLFGWKDEQPWHGAEPQCELS----DDPGY---VLFSSIGSFYIPLLIMIIVYARIYRAAKRKERR----------- 193
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 156 kVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALkgMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15059 194 -FTLVLGVVMGAFVLCWLPFFFTYPLVVVCKTCGVPEL--LFKFFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
10-223 1.94e-24

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 98.67  E-value: 1.94e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIY-AGLRS 88
Cdd:cd15372  64 NWPFGEGLCRVVTAFFYGNMYCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQrQSYPL 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRSSCTINWP--GESGAWYTGFIIYtFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKrkksekkvtRMVSIVVA 166
Cdd:cd15372 144 ERLNITLCHDVLPldEQDTYLFYYFACL-AVLGFLLPLVVILFCYGSVLHTLLRSGQRYGHAM---------KLTVLVLV 213
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 167 VFIFCWLPFYIFNVSSVSmaiSPTPALKGMFDFVVVLTYA----NSCANPILYAFLSDNFK 223
Cdd:cd15372 214 SFVLCFTPSNLLLLLHYS---DPTLDDGGNLYIVYMVSLAistlNSCVDPFIYYYVSEEFR 271
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
10-226 2.02e-24

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 98.91  E-value: 2.02e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKsaKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd15390  65 DWPFGLFYCKFSNFVAITTVAASVFTLMAISIDRYIAIVHPLR--PRLSRRTTKIAIAVIWLASFLLALPQLLYSTTETY 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QW----GRSSCTINWPGESGAWY-TGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKK----VTRM 160
Cdd:cd15390 143 YYytgsERTVCFIAWPDGPNSLQdFVYNIVLFVVTYFLPLIIMAVAYTRVGVELWGSKTIGENTPRQLESVRakrkVVKM 222
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 161 VSIVVAVFIFCWLPFYIFNV-SSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15390 223 MIVVVVIFAICWLPYHLYFIlTYLYPDINSWKYIQQIYLAIYWLAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
10-226 2.80e-24

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 98.61  E-value: 2.80e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd15375  65 SWIFGEFMCKFIRFIFHFNLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVISLAEVSPMTFLITTKEK 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QwGRSSC---TINWPGESGAWYTGFIIytfILGFLVPLTIICLCYLFIIIKVKSsgirvGSSKRKKSEKKVTRMVSIVVA 166
Cdd:cd15375 145 N-NRTICldfTSSDNLNTIWWYNWILT---VLGFLLPLVIVTLCYTRIIYTLAK-----GPHTGSASKQKARRLIILILL 215
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12652991 167 VFIFCWLPFYIFNVSSVSMAISPTPA-----LKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15375 216 VFYVCFLPFHILRVVRIETRLPPVSCclkhqVHAIYIITRPLAALNTFGNLLLYVVSGDNFQQAF 280
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
9-219 3.69e-24

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 98.65  E-value: 3.69e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   9 VHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAK-WRRprtAKMITMAVWGVSLLVILPIMIYAGLR 87
Cdd:cd15197  64 VEWRAGDFACKVIRYLQVVVTYASTYVLVALSIDRYDAICHPMNFSQsGRQ---ARVLICVAWILSALFSIPMLIIFEKT 140
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  88 SNQWGRSSCTINWPGESgAWYTGFIIYTFILgFLVPLTIICLCYLFIIIKV----------KSSGIRVGSSKRKKSEKKV 157
Cdd:cd15197 141 GLSNGEVQCWILWPEPW-YWKVYMTIVAFLV-FFIPATIISICYIIIVRTIwkkskiqvtiNKAGLHDGSSRRSSSRGII 218
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 158 TR-------MVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLS 219
Cdd:cd15197 219 PRakiktikMTFVIVTVFIICWSPYFVFDLLDVFGLLPRSKTKIAAATFIQSLAPLNSAINPLIYCLFS 287
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
11-226 3.94e-24

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 97.43  E-value: 3.94e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIyAGLRSNQ 90
Cdd:cd15061  65 WPLGSHLCDFWISLDVLLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLV-GPSWHGR 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTINWPgesgawyTGFIIYTFILGFLVPLTIICLCYL--FIIIKVKSSGIRVgsskrkksekkvtrmVSIVVAVF 168
Cdd:cd15061 144 RGLGSCYYTYD-------KGYRIYSSMGSFFLPLLLMLFVYLriFRVIAKERKTAKT---------------LAIVVGCF 201
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 12652991 169 IFCWLPFYIFNVSSVSMAISPTPALKgmfDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15061 202 IVCWLPFFIMYLIEPFCDCQFSEALS---TAFTWLGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
11-226 5.23e-24

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 98.17  E-value: 5.23e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGL---- 86
Cdd:cd15134  67 WVFGEVFCKLRAFLSEMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFAIQTRIvyle 146
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  87 -----RSNQWGRSSCTINwpgESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGI-------RVGSSKRKKSE 154
Cdd:cd15134 147 ypptsGEALEESAFCAML---NEIPPITPVFQLSTFLFFIIPMIAIIVLYVLIGLQLRRSTLlrrgqrsVSGGRRSSQSR 223
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 155 KKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAiSPTPALKGMFDFVV----VLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15134 224 RTVLRMLVAVVVAFFICWAPFHAQRLLTVYAK-NMTPPYLFINRILFyisgVLYYVSSTVNPILYNVMSAKYRQAF 298
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
1-225 5.40e-24

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 97.64  E-value: 5.40e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVAL-VHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILP 79
Cdd:cd15925  56 FWAVESALdFHWPFGGAMCKMVLTATVLNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVP 135
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  80 IMIYAgLRSNQWGRSSCTINWPgeSGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSsgiRVGSSKRKKSEKKVTR 159
Cdd:cd15925 136 TAIFA-TEGEVCGVELCLLKFP--SNYWLGAYHLQRVVVAFVVPLGVITTSYLLLLSFLQQ---HKVNQNNRQRQSVIAR 209
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 160 MVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKG-------MFDFVVVLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15925 210 SVRLVVASFFLCWFPNHVVTFWGVLVKFRAVPWNSTfyfihtyVFPVTTCLAHSNSCLNPVLYCLMRREFRQA 282
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
11-222 1.02e-23

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 97.18  E-value: 1.02e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd15118  65 WELGTTFCRIHSSIFFLNMFVSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPYFVFRDVIERK 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTINW----PGES------GAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRvgsskrkkSEKKVTRM 160
Cdd:cd15118 145 DGRKLCYYNFalfsPSPDnnhpicKQRQEGLAISKLLLAFLIPLVIIAVSYAVVSLIIRHRCRR--------RPGRFVRL 216
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12652991 161 VSIVVAVFIFCWLPFYIFNVSSVSMAISPT--PALKGMFDFVVVLTYANSCANPILYAFLSDNF 222
Cdd:cd15118 217 VVSVVVSFALCWAPYHIFSIIEVMAHNQHSlrPLVIQGLPFATTLAFLNSVLNPVLYVFSCPDF 280
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
8-226 1.25e-23

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 97.05  E-value: 1.25e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   8 LVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKsAKWRRPRTAkMITMAVWGVSLLVILPIMIYAGL- 86
Cdd:cd15392  64 LQYWPFGEFMCPVVNYLQAVSVFVSAFTLVAISIDRYVAIMWPLR-PRMTKRQAL-LLIAVIWIFALATALPIAITSRLf 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  87 --RSNQWGRSSCTINWPGESGAWYTGFIIytFILGFLVPLTIICLCYLFIIIKV----------KSSGIRVgsskrKKSE 154
Cdd:cd15392 142 edSNASCGQYICTESWPSDTNRYIYSLVL--MILQYFVPLAVLVFTYTRIGIVVwakrtpgeaeNNRDQRM-----AESK 214
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 155 KKVTRMVSIVVAVFIFCWLPFYIFN-VSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15392 215 RKLVKMMITVVAIFALCWLPLNILNlVGDHDESIYSWPYIPYLWLAAHWLAMSHCCYNPFIYCWMNAKFRNGF 287
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
11-240 1.83e-23

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 97.16  E-value: 1.83e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:PHA03087 104 WSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDH 183
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   91 wGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIrvgsskrKKSEKKVTRMVSIVVAVFIF 170
Cdd:PHA03087 184 -ETLICCMFYNNKTMNWKLFINFEINIIGMLIPLTILLYCYSKILITLKGINK-------SKKNKKAIKLVLIIVILFVI 255
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991  171 CWLPFYIfNVSSVSMAISPTPALKGMFDFVVVLTYA-------NSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDD 240
Cdd:PHA03087 256 FWLPFNV-SVFVYSLHILHFKSGCKAVKYIQYALHVteiislsHCCINPLIYAFVSEFFNKHKKKSLKLMFTSSGKS 331
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
2-226 3.94e-23

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 95.09  E-value: 3.94e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   2 LAMQVALVH-----WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV 76
Cdd:cd15064  52 LVMPLSAVYeltgrWILGQVLCDIWISLDVTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICI 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  77 ILPIMiYAGLRSNQWGRSSCTINwpgesgaWYTGFIIYTFILGFLVPLTIIcLCYLFIIIKVKSSGIRvgsskrkksekk 156
Cdd:cd15064 132 SLPPL-FGWRTPDSEDPSECLIS-------QDIGYTIFSTFGAFYIPLLLM-LILYWKIYRAAARERK------------ 190
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 157 VTRMVSIVVAVFIFCWLPFYIfnVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15064 191 AAKTLGIILGAFIVCWLPFFL--VALIVPLCSHCWIPLALKSFFLWLGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
6-223 6.83e-23

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 95.14  E-value: 6.83e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   6 VALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKwRRPRTAKMITMAvWGVSLLVILPIMIYAG 85
Cdd:cd14986  61 EATGEWVAGDVLCRIVKYLQVVGLFASTYILVSMSLDRYQAIVKPMSSLK-PRKRARLMIVVA-WVLSFLFSIPQLVIFV 138
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  86 LRSNQWGRSSCTINWPGESGawYTGFIIYTFILGFLVPLTIICLCYLFIIIKV--------------------KSSGIRV 145
Cdd:cd14986 139 ERELGDGVHQCWSSFYTPWQ--RKVYITWLATYVFVIPLIILSYCYGRILRTIwirsrqktdrpiaptamscrSVSCVSS 216
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 146 GSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKgmfdFVVVLTYA--NSCANPILYAFLSDNFK 223
Cdd:cd14986 217 RVSLISRAKIKTIKMTLVIILAFILCWTPYFIVQLLDVYAGMQQLENDA----YVVSETLAslNSALNPLIYGFFSSHLS 292
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
11-226 1.27e-22

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 94.16  E-value: 1.27e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIK-SAKWRRPRTAKMITMAvWGVSLLVILPIMIyagLRSN 89
Cdd:cd15055  66 WYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLyPTKITIRRVKICICLC-WFVSALYSSVLLY---DNLN 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRS---SCtinwPGE-----SGAWYTgfiiYTFILGFLVPLTIICLCYL--FIIIKVKSSGIR-VGSSKRKKSEKKVT 158
Cdd:cd15055 142 QPGLIrynSC----YGEcvvvvNFIWGV----VDLVLTFILPCTVMIVLYMriFVVARSQARAIRsHTAQVSLEGSSKKV 213
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 159 RMVS---------IVVAVFIFCWLPFYIFNVSSVSMAISPTPalkgmFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15055 214 SKKSerkaaktlgIVVGVFLLCWLPYYIVSLVDPYISTPSSV-----FDVLIWLGYFNSCLNPLIYALFYPWFRKAL 285
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
1-223 1.71e-22

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 93.70  E-value: 1.71e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALvHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd15188  56 FWAMYVAW-HWVFGSFLCKFVSTLYTINFYSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPD 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFI---IIKVKSSGIRvgsskrkksekKV 157
Cdd:cd15188 135 MVFVQTHHTNNGVWVCHADYGGHHTIWKLVFQFQQNLLGFLFPLLAMVFFYSRIacvLTRLRPPGQG-----------RA 203
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12652991 158 TRMVSIVVAVFIFCWLPFYI--FNVSSVSMAISPTPALKGMFDFVVVLT----YANSCANPILYAFLSDNFK 223
Cdd:cd15188 204 LRFVAALVVVFFVLWFPYNLtlFLHSLQDLHVIGNCERSRHLDYALQVTeslaFVHCCLNPLLYAFVSKRFR 275
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
10-226 1.79e-22

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 93.57  E-value: 1.79e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIyAGLRSN 89
Cdd:cd15159  65 DWPFGDWLCRLTALLFYINTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLPLLF-MPMTKE 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCtINWPGESGAWYTGFI-IYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVF 168
Cdd:cd15159 144 MGGRITC-MEYPNFEKIKRLPLIlLGACVIGFGVPVGIILFCYSQITLKLCRTAKENPLTEKSGHHKKACNVILLVLLVF 222
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12652991 169 IFCWLPFYIFNVSSVSMAISPTP------ALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15159 223 VVCFSPYHLNIIQFMIRKLLYQPscselkAFKISLQITVCLMNLNCCLDPFIYFFACKGYKKKV 286
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
10-226 1.98e-22

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 93.42  E-value: 1.98e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRV---VMTVDGInqfTSIFCLTVMSIDRYLAVVHPIKsAKWRRPRTAKMITMAVWGVSLLVILPIMIyagl 86
Cdd:cd14969  65 RWSFGDPGCVIygfAVTFLGL---VSISTLAALAFERYLVIVRPLK-AFRLSKRRALILIAFIWLYGLFWALPPLF---- 136
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  87 rsnQWGR-------SSCTINWPGESGAWYTgFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKK--- 156
Cdd:cd14969 137 ---GWSSyvpegggTSCSVDWYSKDPNSLS-YIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRtkk 212
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 157 ----VTRMVSIVVAVFIFCWLP-----FY--IFNVSSVSMAISPTPALkgmfdfvvvLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd14969 213 aekkVAKMVLVMIVAFLIAWTPyavvsLYvsFGGESTIPPLLATIPAL---------FAKSSTIYNPIIYVFMNKQFRRA 283

                .
gi 12652991 226 F 226
Cdd:cd14969 284 L 284
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
10-223 1.98e-22

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 93.67  E-value: 1.98e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIY-AGLRS 88
Cdd:cd14987  65 QWPMGEFTCKITHLIFSINLFGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPDTYFlKTVTS 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRSSCTINWPGES-GAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRvgsskrkkSEKKVTRMVSIVVAV 167
Cdd:cd14987 145 PSNNETYCRSFYPEESfKEWLIGMELVSIVLGFVIPFPIIAVFYFLLARAISASSDQ--------ERKSSRKIIFSYVVV 216
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 168 FIFCWLPFY---IFNVSSVSMAISPTPALKGMFDFVVVLTYANS----CANPILYAFLSDNFK 223
Cdd:cd14987 217 FLVCWLPYHtvvLLDILSFLHLIPFSCQLENFLYAALHVTQCFSlvhcCVNPILYSFINRNYR 279
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
5-218 5.77e-22

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 92.23  E-value: 5.77e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   5 QVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYA 84
Cdd:cd15194  60 EVVLGPWRSGSFLCKGSSYIISVNMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSR 139
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  85 GLRSNQwGRSSCTinwPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKvtRMVSIV 164
Cdd:cd15194 140 ELKKYE-EKEYCN---EDAGTPSKVIFSLVSLIVAFFLPLLSILTCYCTIIWKLCHHYQKSGKHQKKLRKSI--KIVFIV 213
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 165 VAVFIFCWLPFYIF-------NVSSVSMAISPTPALKGMfDFVVVLTYANSCANPILYAFL 218
Cdd:cd15194 214 VAAFVFSWMPFNLFkalaiasGLQVEVTCLPYTLAQLGM-EVSAPLAFANSCANPFIYYFF 273
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
10-226 8.45e-22

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 91.74  E-value: 8.45e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd14991  65 HWIFGEAWCRVNLFMLSVNRSASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLPLLLSTLLTVN 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QwGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIIclcyLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFI 169
Cdd:cd14991 145 S-NKSSCHSFSSYTKPSLSIRWHNALFLLEFFLPLGLI----VFCSVRIACNLRIRQSLGKQARVQRAIRLVFLVVIVFV 219
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 170 FCWLPFYIFNVSSV----SMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd14991 220 LCFLPSIIAGLLALvfknLGSCRCLNSVAQLFHISLAFTYLNSALDPVIYCFSSPWFRNSL 280
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
10-225 1.53e-21

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 90.97  E-value: 1.53e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd15012  64 SWPFGEVLCRMYQFVHSLSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEI 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 ------QWGRSSCTINWPGESGAWYTgfiiYTFILGFLVPLTIICLCYLFIIIKV-KSSGIRvgsskrkkSEKKVTRMVS 162
Cdd:cd15012 144 lvtqdgQEEEICVLDREMFNSKLYDT----INFIVWYLIPLLIMTVLYSKISIVLwKSSSIE--------ARRKVVRLLV 211
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 163 IVVAVFIFCWLPFY---IFNVSSVSMAISPTPALKgMFDFVVVLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15012 212 AVVVSFALCNLPYHarkMWQYWSEPYRCDSNWNAL-LTPLTFLVLYFNSAVNPLLYAFLSKRFRQS 276
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
11-226 1.58e-21

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 91.30  E-value: 1.58e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPI--KSAKWRrprtAKMITMAVWGVSLLVILPIMIYAGLRS 88
Cdd:cd15208  66 WFFGQVLCKIIPYLQTVSVSVSVLTLSCIALDRWYAICHPLmfKSTAKR----ARVSILIIWIVSLLIMIPQAIVMECSR 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGR------SSCTINWPGESgaWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKK------ 156
Cdd:cd15208 142 VVPLAnktillTVCDERWSDSI--YQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSVVQRKWNKprksav 219
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 157 ------------VTRMVSIVVAVFIFCWLPFYIFNV--SSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNF 222
Cdd:cd15208 220 aaeekqlrsrrkTAKMLIVVVIMFAICYLPVHLLNIlrYVFGLFTVDRETIYAWFLFSHWLVYANSAINPIIYNFMSGKF 299

                ....
gi 12652991 223 KKSF 226
Cdd:cd15208 300 REEF 303
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
10-226 1.79e-21

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 90.93  E-value: 1.79e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGvsLLVILPIMIYAGLRSN 89
Cdd:cd15157  65 HWVFGDIACRIMSYSLYVNMYCSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWI--FVMAASSPLLSKGTSK 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINWPGESGAWytgFIIYTFIL--GFLVPLTIICLCYLFII-----IKVKSSGIRVgsskrkkSEKKVTRMVS 162
Cdd:cd15157 143 YNSQTKCLDLHPSKIDKL---LILNYIVLvvGFILPFCTLSICYILIIkallkPRVPQSKLRV-------SHKKALLTII 212
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 163 IVVAVFIFCWLPFYIFNVSSVsMAISPTPALKGMFDFVVV---LTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15157 213 ITLILFLLCFLPYHILRTVHL-MQWSEGQCNLRLHKAVVItlcLAAANSCLDPLLYYFAGENFKERL 278
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
10-226 1.84e-21

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 90.38  E-value: 1.84e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd15323  65 YWYFGQVWCNIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDPE 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINwpgeSGAWYtgfIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRvgsskrkksekkVTRMVSIVVAVFI 169
Cdd:cd15323 145 GDVYPQCKLN----DETWY---ILSSCIGSFFAPCLIMILVYIRIYRVAKAREKR------------FTFVLAVVMGVFV 205
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 170 FCWLPFYiFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15323 206 VCWFPFF-FSYSLYGICREACEVPEPLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
11-223 2.62e-21

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 90.52  E-value: 2.62e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd15160  66 WTFGPLSCKVVGFFFYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFLGHDELFRDE 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTINWPgeSGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirvgSSKRKKSEKKVTRMVSIVVAVFIF 170
Cdd:cd15160 146 PNHTLCYEKYP--MEGWQASYNYARFLVGFLIPLSLILFFYRRVLRAVRQS-----PSLEREEKRKIIGLLLSIVVIFLL 218
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 171 CWLPFYI--FNVSSVSMAISPT----PALKGMFDFVVVLTYANSCANPILYAFLSDNFK 223
Cdd:cd15160 219 CFLPYHVvlLVRSVIELVQNGLcgfeKRVFTAYQISLCLTSLNCVADPILYIFVTEDVR 277
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
11-226 2.94e-21

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 90.20  E-value: 2.94e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTA--KMITMAVWGVSLLVILPIMIYAGLRS 88
Cdd:cd15172  64 WIFGNFSCKLLRGIYAINFYSGMLLLACISVDRYIAIVQATKSFRLRSRTLAysKLICAAVWLLAILISLPTFIFSEVYD 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQW-GRSSCTINWPGESGA--WYTGFIIYTFILGFLVPLTIICLCYLFII---IKVKSSgirvgsskrkkSEKKVTRMVS 162
Cdd:cd15172 144 FGLeEQYVCEPKYPKNSTAimWKLLVLSLQVSLGFFIPLLVMIFCYSFIIktlLQAQNS-----------QRHKAVRVVV 212
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 163 IVVAVFIFCWLPFYIFNVSSVS----MAISPTPALKGMFDFVV-VLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15172 213 AVVLVFLVCQVPYNIVLLIEAInlgeQQSCSSEKAVAYAKTITeCLAFFHCCLNPVLYAFIGVKFRNYF 281
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
11-224 3.09e-21

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 90.20  E-value: 3.09e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRT--AKMITMAVWGVSLLVILPIMIYAGLRs 88
Cdd:cd15174  64 WVFGTFLCKVVNSMYKINFYSCMLLLTCISVDRYIAIVQATKAHNSKNKRLlySKLVCFFVWLLSTILSLPEILFSQSK- 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRSSCTIN-WPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFII---IKVKSSgirvgsskrkkSEKKVTRMVSIV 164
Cdd:cd15174 143 EEESVTTCTMVyPSNESNRFKVAVLALKVTVGFFLPFVVMVICYTLIIhtlLQAKRF-----------QKHKALKVIIAV 211
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 165 VAVFIFCWLPFYIFNVSSV----SMAISPTPALKGM---FDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15174 212 VTVFVLSQLPYNSILLIKTinayNITITDCATSQNLdiaGQVTQSIAFLHSCLNPFLYVFVGVRFRK 278
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
1-226 3.10e-21

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 90.57  E-value: 3.10e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKaICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILP 79
Cdd:cd15057  57 WAAVNEVAGYWPFGS-FCDVWVSFDIMCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALIsFIP 135
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  80 IMI---YAGLRSNQWGRSSCTINWPGESGAWYTgfiIYTFILGFLVPLTIICLCY--LFIIIKVK-------------SS 141
Cdd:cd15057 136 VQLgwhRADDTSEALALYADPCQCDSSLNRTYA---ISSSLISFYIPVAIMIVTYtrIYRIARRQirriaaleraaqeST 212
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 142 GIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNV--------SSVSMAISPTpalkgMFDFVVVLTYANSCANPI 213
Cdd:cd15057 213 NPDSSLRSSLRRETKALKTLSIIMGVFVCCWLPFFILNCvlpfcdlrTAQFPCVPDT-----TFIVFVWLGWANSSLNPI 287
                       250
                ....*....|...
gi 12652991 214 LYAFLSDnFKKSF 226
Cdd:cd15057 288 IYAFNAD-FRKAF 299
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
13-226 3.48e-21

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 89.87  E-value: 3.48e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  13 FGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWG 92
Cdd:cd15979  68 FGEVICKAVAYLMGVSVSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVG 147
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  93 RSS----CTINWPGE--SGAWYtgfiIYTFILGFLVPLTIICLCYLFIiikvkSSGIRVGsskrKKSEKKVTRMVSIVVA 166
Cdd:cd15979 148 DRPrghqCRHAWPSAqvRQAWY----VLLLLILFFIPGVVMIVAYGLI-----SRELYRG----LLAKKRVIRMLVVIVA 214
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 167 VFIFCWLPFYIFNVSSVSMAISPTPALKGM-FDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15979 215 MFFLCWLPIFSANTWRAFDPLSAHRALSGApISFIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
13-226 3.97e-21

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 89.93  E-value: 3.97e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  13 FGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGL----RS 88
Cdd:cd15978  68 FGSAVCKTATYFMGISVSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLvpftRI 147
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRSSCTINWPGE--SGAWYtgfiIYTFILGFLVPLTIICLCYLFIIIKVkSSGIRVgsskrKKSEKKVTRMVSIVVA 166
Cdd:cd15978 148 NNSTGNMCRLLWPNDvtQQSWY----IFLLLILFLIPGIVMMTAYGLISLEL-YRGIKF-----LMAKKRVIRMLIVIVI 217
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 167 VFIFCWLPFYIFNVSSVSMAISPTPALKGM-FDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15978 218 LFFLCWTPIFSANAWRAFDTRSADRLLSGApISFIHLLSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
1-225 4.73e-21

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 89.88  E-value: 4.73e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRrpRTAKMITMAVWGVSLLvILPI 80
Cdd:cd15391  56 FTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTNTAIGIDRFFAVIFPLRSRHTK--SRTKCIIASIWAISFS-LSSV 132
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLRSNQW----GRSSCTINWPGESgAWYTGFIIYTFILGFLVPLTIICLCYLFIII-----KVKSSGIRVGSSKRK 151
Cdd:cd15391 133 QLFAGRTQRYGqyseGRVLCGESWPGPD-TSRSAYTVFVMLLTYIIPLLILTSTYGYVGFrlwnrTAPGNADKGRDDMQI 211
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 152 KSEKKVTRMVSIVVAVFIFCWLPFYIFN-VSSVSMAISPTP--ALKGMFDFVVVLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15391 212 KSKRKVIKMLVFVVLMFGICWLPLHLFNlVQDFSTVFRNMPqhTTRLIYGACHWIAMSNSFVNPIIYLFMNDSFRSI 288
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
1-226 5.91e-21

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 89.44  E-value: 5.91e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALvHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKS--AKWRRPRTAKMITMAVWGVSLLVIL 78
Cdd:cd15173  55 FWAYSAAH-EWIFGTVMCKITNGLYTINLYSSMLILTCITVDRFIVIVQATKAhnCHAKKMRWGKVVCTLVWVISLLLSL 133
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  79 PIMIYaglrSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGirvgsskrKKSEKKVT 158
Cdd:cd15173 134 PQFIY----SEVRNLSSKICSMVYPPDAIEVVVNIIQMTVGFFLPLLAMIICYSVIIKTLLHAK--------GFQKHKSL 201
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12652991 159 RMVSIVVAVFIFCWLPfyiFNVSSVSMAISPTPALKGMFDFVVVLT----YANSCANPILYAFLSDNFKKSF 226
Cdd:cd15173 202 KIIFVVVAVFILTQLP---YNIMKLIRTLHIENTDSTNFKYAILITeaiaYLHACLNPILYAFVGVKFRKNF 270
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
10-226 6.01e-21

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 89.44  E-value: 6.01e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIY-AGLRS 88
Cdd:cd15368  65 HWIFGKPLCNVVTVLFYANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSPLERTdLTYYV 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRSSC--TINWPG-ESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEkkvtRMVSIVV 165
Cdd:cd15368 145 KELNITTCfdVLKWTMlPNIAAWAAFLFTLFILLFLIPFIITVYCYVLIILKLVQTSERYGREQKRRAI----YLALIVL 220
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 166 AVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15368 221 LVFITCFAPNNFILLAHMVSRLFYGKSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
14-224 7.99e-21

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 88.83  E-value: 7.99e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  14 GKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAvWGVSLLVILPIMIYAGLRSNQWGR 93
Cdd:cd15196  69 GDLLCRLVKYLQVVGMYASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAIA-WVLSLLLSIPQLFIFSYQEVGSGV 147
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  94 SSCtinWPGESGAW-YTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRvgsskrkksekkVTRMVSIVVAVFIFCW 172
Cdd:cd15196 148 YDC---WATFEPPWgLRAYITWFTVAVFVVPLIILAFCYGRICYVVWRAKIK------------TVKLTLVVVACYIVCW 212
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 12652991 173 LPFYifnVSSVSMAISPTPALKGMFdFVVVLTYA--NSCANPILYAFLSDNFKK 224
Cdd:cd15196 213 TPFF---VVQMWAAWDPTAPIEGPA-FVIIMLLAslNSCTNPWIYLAFSGNLRR 262
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
11-226 8.41e-21

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 89.34  E-value: 8.41e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRS-- 88
Cdd:cd14979  67 WAFGDGGCKLYYFLFEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIQYln 146
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 --NQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKS-----------SGIRVGSSKRKKSEK 155
Cdd:cd14979 147 gpLPGPVPDSAVCTLVVDRSTFKYVFQVSTFIFFVLPMFVISILYFRIGVKLRSmrnikkgtraqGTRNVELSLSQQARR 226
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12652991 156 KVTRMVSIVVAVFIFCWLPF----YIFNVSSvSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd14979 227 QVVKMLGAVVIAFFVCWLPFhaqrLMFSYAS-KEDTFLFDFYQYLYPISGILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
11-226 8.41e-21

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 89.26  E-value: 8.41e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKwrRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd15204  68 WTHGDVLCAVVNYLRTVSLYVSTNALLVIAIDRYLVIVHPLKPRM--KRRTACVVIALVWVVSLLLAIPSAVYSKTTPYA 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSS-CTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKV--------KSSGIRvgssKRKKSEKKVTRMV 161
Cdd:cd15204 146 NQGKIfCGQIWPVDQQAYYKAYYLFLFVLEFVLPVLIMTLCYLRIVRKVwfrrvpgqQTEQIR----RRLRRRRRKVRLL 221
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 162 SIVVAVFIFCWLPFYIFnvsSVSMAISPTPALK-----GMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15204 222 VVILTAFVLCWAPYYGY---AIVRDFFPTLLSKeklntTIFYIVEALAMSNSMINTVVYVAFNNNIRKYL 288
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
10-225 1.12e-20

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 88.66  E-value: 1.12e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSn 89
Cdd:cd15373  65 DWPFSEALCKIVRFLFYTNLYCSILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLYFVTTSD- 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 qwgRSSCTINWPGESGAWYTGFIIY---TFILGFLVPLTIICLCYLFIIIKVKSSgiRVGSSKRKKSEKKVTRMVSIVVA 166
Cdd:cd15373 144 ---KGGNITCHDTSSPELFDQFVVYssvMLVLLFCVPFVVILVCYALMVRKLLKP--SAGTSTNSRSKKKSVKMIIIVLA 218
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12652991 167 VFIFCWLPFYI-----FNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15373 219 VFILCFLPFHVtrtlyYSFRSMDLSCGTLNAINLAYKVTRPLASANSCLDPILYFLAGQSFRSN 282
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
2-226 1.13e-20

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 88.48  E-value: 1.13e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   2 LAMQVALV-----HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRP-RTAKMITmAVWGVSLL 75
Cdd:cd15329  52 LVMPLAIIyelsgYWPFGEILCDVWISFDVLLCTASILNLCAISVDRYLVITRPLTYAVKRTPkRMALMIA-IVWLLSAL 130
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  76 VILPIMIyaGLRSNQWGRSSCTINwpgeSGAWYTgfiIYTFILGFLVPLTIICLCYLFIIIKVKSSGirvgsskrkksek 155
Cdd:cd15329 131 ISIPPLF--GWKNKVNDPGVCQVS----QDFGYQ---IYATFGAFYIPLIVMLVLYYKIYRAAKSER------------- 188
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12652991 156 KVTRMVSIVVAVFIFCWLPFYIFNVS-SVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15329 189 KAIKTLGIIMGAFTLCWLPFFILALLrPFLKPIKCSCIPLWLSRLFLWLGYANSFLNPIIYAKFNREFRTPF 260
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
10-224 1.59e-20

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 88.32  E-value: 1.59e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLrSN 89
Cdd:cd15374  65 HWPFGVVACKIVRFLFYANLYCSILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFVTT-SR 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFI 169
Cdd:cd15374 144 KDNITLCHDTTRPEEFDHYVHYSSAVMVLLFGIPCLVIVVCYGLMARRLCKPRVGSSRQQGPSSKKRSLKTIIMVLTVFA 223
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 170 FCWLPFYIF-NVSSVSMAISPTPALKGMFDFVVVLTY----ANSCANPILYAFLSDNFKK 224
Cdd:cd15374 224 ICFVPFHITrTLYYVARLLKADCDTLNIINVTYKVTRplasANSCLDPILYFLAGDKYRR 283
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
10-226 2.70e-20

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 87.31  E-value: 2.70e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd15322  65 YWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSG 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINwpgeSGAWYtgfIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRvgsskrkksekkVTRMVSIVVAVFI 169
Cdd:cd15322 145 QPEGPICKIN----DEKWY---IISSCIGSFFAPCLIMVLVYIRIYQIAKNREKR------------FTFVLAVVIGVFV 205
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 12652991 170 FCWLPFYI-FNVSSVSMAISPTPalkgMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15322 206 ICWFPFFFtYTLTAVCDCSVPET----LFKFFFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
11-224 2.78e-20

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 88.04  E-value: 2.78e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd15377  66 WIFGDAMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRK 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIF 170
Cdd:cd15377 146 NKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPFILILGCYGLIVRALIYKDMKYTEENNAPLRRKSIYLVIIVLTVFAV 225
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12652991 171 CWLPFYIFNVSSVSMAIS-PTPALKGMFDFVVV-------LTYANSCANPILYAFLSDNFKK 224
Cdd:cd15377 226 SYLPFHVMKTLNLRARLDfQTPAMCAFNDRVYAtyqvtrgLASLNSCVDPILYFLAGDTFRR 287
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
10-226 5.56e-20

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 86.60  E-value: 5.56e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLR-S 88
Cdd:cd15052  66 VWPLPLVLCLLWVTLDVLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGIIDtT 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRSSCTINWPgesgawytGFIIYTFILGFLVPLTIICLCYlFIIIKVKSSGIRvgsskrkksekkVTRMVSIVVAVF 168
Cdd:cd15052 146 NVLNNGTCVLFNP--------NFVIYGSIVAFFIPLLIMVVTY-ALTIRLLSNEQK------------ASKVLGIVFAVF 204
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 12652991 169 IFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15052 205 VICWCPFFITNILTGLCEECNCRISPWLLSVFVWLGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
10-226 6.78e-20

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 86.79  E-value: 6.78e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYaglRSN 89
Cdd:cd15921  65 HWPFGDIACRIILYVLYVNMYSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFA---KSK 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINWPGESGAWYTGFIIY-TFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVtrMVSIVVAVF 168
Cdd:cd15921 142 QHDEGSTRCLELAHDAVDKLLLINYvTLPVGFVVPFMTVIFCYIFIIKNLLKPSPALGRTRPSRRKACA--LIIISLGIF 219
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12652991 169 IFCWLPFYIFNVSSVSMAISPTP------ALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15921 220 LVCFLPYHIVRTIHLITERQIKEscgyilRVRKAAVITLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
10-222 9.01e-20

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 86.37  E-value: 9.01e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYA--GLR 87
Cdd:cd15968  65 RWLFGDFMCRLVRFLFYFNLYGSILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFArtGII 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  88 SNqwgRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgIRVGSSKRKKSEKKVTRMVSIVVAV 167
Cdd:cd15968 145 RN---RTVCYDLAPPALFPHYVPYGMALTVSGFLLPFSIILWCYCLVVRTLCRT-LGPAEPPAQARRRKSIRTIVTVTLL 220
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 168 FIFCWLPFYIfnVSSVSMAISPTPALKGMFDFVVVLTY--------ANSCANPILYAFLSDNF 222
Cdd:cd15968 221 FALCFLPFHI--TRTIYLAVRVTPGVPCHVLEAVAACYkitrplasANSVLNPLLYFLTKKKF 281
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
10-226 9.50e-20

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 86.23  E-value: 9.50e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILPIMIyaGLRS 88
Cdd:cd15051  65 EWPLGPVFCNIYISLDVMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVsFLPIHL--GWNT 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWG------RSSCTINWpgesGAWYTgfIIYTFiLGFLVPLTIICLCYLFI----------IIKV-KSSGIRVGSSKRK 151
Cdd:cd15051 143 PDGRvqngdtPNQCRFEL----NPPYV--LLVAI-GTFYLPLLIMCGVYLRIfriareqakrINALtPASTANSSKSAAT 215
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12652991 152 KSEKKVTRMVSIVVAVFIFCWLPFYIFnvsSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15051 216 AREHKATVTLAAVLGAFIICWFPYFTY---FTYRGLCGDNINETALSVVLWLGYANSALNPILYAFLNRDFRRAF 287
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
11-224 9.96e-20

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 86.17  E-value: 9.96e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITmAVWGVSLLV-ILPImiyAGlrsn 89
Cdd:cd15074  66 WLFGDIGCVFYGFCGFLFGCCSINTLTAISIYRYLKICHPPYGPKLSRRHVCIVIV-AIWLYALFWaVAPL---VG---- 137
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 qWGR-------SSCTINWPG-ESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEK-----K 156
Cdd:cd15074 138 -WGSygpepfgTSCSIDWTGaSASVGGMSYIISIFIFCYLLPVLIIVFSYVKIIRKVKSSRKRVAGFDSRSKRQhkierK 216
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 157 VTRMVSIVVAVFIFCWLPfyiFNVSSVSMAISPTPALKGMFDFVVVLTYANSCA-NPILYAFLSDNFKK 224
Cdd:cd15074 217 VTKVAVLICAGFLIAWTP---YAVVSMWSAFGSPDSVPILASILPALFAKSSCMyNPIIYLLFSSKFRQ 282
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
8-233 1.17e-19

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 86.50  E-value: 1.17e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991    8 LVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKsAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLr 87
Cdd:PHA02834  88 LNEWIFGEFMCKLVLGVYFVGFFSNMFFVTLISIDRYILVVNATK-IKNKSISLSVLLSVAAWVCSVILSMPAMVLYYV- 165
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   88 SNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGsskrkksekkvTRMVSIVVAV 167
Cdd:PHA02834 166 DNTDNLKQCIFNDYHENFSWSAFFNFEINIFGIVIPLIILIYCYSKILYTLKNCKNKNK-----------TRSIKIILTV 234
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991  168 FIFC---WLPFYI-------FNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLV 233
Cdd:PHA02834 235 VTFTvvfWVPFNIvlfinslQSVGLIDIGCYHFKKIVYSIDIAELISFVHCCVNPIIYAFVGKNFKKVFKNMFCRT 310
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
11-226 1.32e-19

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 85.49  E-value: 1.32e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIyaglrsnq 90
Cdd:cd15067  66 WLFGRDWCDVWHSFDVLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAIA-------- 137
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTINwPGESGAWYTGFIIYTFI---LGFLVPLTIICLCYLFI-IIKVKSSgirvgsskrkksekKVTRMVSIVVA 166
Cdd:cd15067 138 WWRAVDPGP-SPPNQCLFTDDSGYLIFsscVSFYIPLVVMLFTYYRIyRAAAKEQ--------------KAAKTLGIVMG 202
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 167 VFIFCWLPFYIFNvssVSMAISPTPALKG---MFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15067 203 VFILCWLPFFVTN---ILIGFCPSNCVSNpdiLFPLVTWLGYINSGMNPIIYACSSRDFRRAF 262
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
10-226 1.49e-19

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 85.92  E-value: 1.49e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYagLRSN 89
Cdd:cd15922  65 HWPFGQFLCQLKVFLLSTHMYGSIYFLMLISIHRYVTVVHYNWKSLWKKKSFMKKLCLGVWLLLFVQGLPFFFV--LKTS 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSS-CTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFI---IIKVKSSGIRvgsskRKKSEKKVTRMVSIVV 165
Cdd:cd15922 143 VIDGKTkCLSIHQSELSLLYFVWNFVLLILGFLLPFGVSLTCYALLgasIAKMNSNNAR-----GRAMKAKSLQMIGISL 217
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 166 AVFIFCWLPFYIFNVSSV------SMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15922 218 VIFIICFVPLHVTRTVGVvvklfyPESCTLLHKVEVAYYISWVLTGVNCCLDPLLYCFASEKFRKSF 284
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
10-226 1.57e-19

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 85.49  E-value: 1.57e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd15201  65 HWKFGDIPCRIVLFMLAMNRAGSIFFLTAVAVDRYFRVVHPHHRINSISVRKAAIIACGLWLLTIAMTVYLLTKKHLFPR 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QwGRSSC----TINWPGESGAWYTGFiiytFILGFLVPLTIICLCYLFIIIKVKSSGIrvgssKRKKSEKKVTRMVSIVV 165
Cdd:cd15201 145 G-NATQCesfnICTGTDSSSNWHEAM----FLLEFFLPLAIILYCSVRIIWQLRGRQL-----DRHAKIKRAVQFIMVVA 214
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 166 AVFIFCWLP-----FYIFNVSSVSMAISPT-PALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15201 215 IVFIICFLPsnvtrIAIWILKHTSNEDCQYyRSVDLAFYITISFTYFNSMLDPVVYYFSSPSFKNFY 281
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
11-226 2.04e-19

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 85.45  E-value: 2.04e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLL-VILPIMiyaglrsn 89
Cdd:cd15337  67 WIWGKVACELYGFAGGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLwSIPPFF-------- 138
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGR-------SSCTINWPGESGAWYTgFIIYTFILGFLVPLTIICLCYLFIIIKVKSSG-------------IRVGSSK 149
Cdd:cd15337 139 GWGRyvpegfqTSCTFDYLSRDLNNRL-FILGLFIFGFLCPLLIIIFCYVNIIRAVRNHEkemtqtaksgmgkDTEKNDA 217
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 150 RKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSV---SMAISPTPA-LKGMFdfvvvlTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15337 218 RKKAEIRIAKVAIILISLFLLSWTPYAVVALLGQfgpAYWITPYVSeLPVMF------AKASAIYNPIIYALSHPKFRAA 291

                .
gi 12652991 226 F 226
Cdd:cd15337 292 L 292
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
11-226 2.26e-19

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 84.98  E-value: 2.26e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGlRSNQ 90
Cdd:cd15335  66 WTLGYFICEIWLSVDMTCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLFWRN-HHDA 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTINWPgesgawYTGFIIYTFILGFLVPLTIICLCYLfiiiKVKSSGIRvgsskrkksEKKVTRMVSIVVAVFIF 170
Cdd:cd15335 145 NIPSQCIIQHD------HVIYTIYSTFGAFYIPLTLILILYY----RIYHAASR---------ERKAARILGLILGAFIL 205
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 171 CWLPFYIFNVSSVSMAISPTPALKgmfDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15335 206 SWLPFFIKELIVGLSVMTVSPEVA---DFLTWLGYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
11-226 3.41e-19

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 84.40  E-value: 3.41e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIM---IYAGLR 87
Cdd:cd15050  66 WILGRPVCLFWLSMDYVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPILgwhHFARGG 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  88 SNQWGRSSCTINWpgesgAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirvgsskrkkseKKVTRMVSIVVAV 167
Cdd:cd15050 146 ERVVLEDKCETDF-----HDVTWFKVLTAILNFYIPSLLMLWFYAKIFKAVNRE-------------RKAAKQLGFIMAA 207
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 168 FIFCWLPFYIFnvsSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15050 208 FILCWIPYFIL---FMVIAFCKNCCNENLHMFTIWLGYINSTLNPFIYPLCNENFKKTF 263
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
9-226 4.38e-19

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 84.76  E-value: 4.38e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   9 VHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRpRTAKMITMAvWGVSLLVILP-IMIYAGLR 87
Cdd:cd15195  64 VEWLAGDLMCRVMMFLKQFGMYLSSFMLVVIALDRVFAILSPLSANQARK-RVKIMLTVA-WVLSALCSIPqSFIFSVLR 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  88 --SNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKV-----------KSSGIRVGSSKRKKSE 154
Cdd:cd15195 142 kmPEQPGFHQCVDFGSAPTKKQERLYYFFTMILSFVIPLIITVTCYLLILFEIskmakrardtpISNRRRSRTNSLERAR 221
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 155 KKVTRMVSIVVAVFIFCWLPFYI----FNVSSVSMAISPTPALKGMFdfvvVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15195 222 MRTLRMTALIVLTFIVCWGPYYVlglwYWFDKESIKNLPPALSHIMF----LLGYLNPCLHPIIYGVFMKEIRNWI 293
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
10-225 5.53e-19

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 83.98  E-value: 5.53e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd15376  66 NWRFGEAACKLERFLFTCNLYGSIFFITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALSAPVLSFSHLEVE 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKV-KSSGIRVgsskrkKSEKKVTRMVSIVVAVF 168
Cdd:cd15376 146 RHNKTECLGTAVDSRLPTYLPYSLFLAVVGCGLPFLLTLASYLAIVWAVlRSPGITT------LEKRKVAALVAVVVALY 219
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12652991 169 IFCWLPFYIF---NVSSVSMAISPTPALKGMFDFVV--VLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15376 220 AVSFVPYHILrnlNLYRRLQWLKAAASLRIYFAYQVtkGLVTLNMCIHPLLYMAVADSIRLC 281
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
11-224 6.17e-19

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 84.02  E-value: 6.17e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKsakwRR--PRTAKMITMAVWGVSLLVILPIMIYA-GLR 87
Cdd:cd15394  67 WVFGRFMCYFVFLMQPVTVYVSVFTLTAIAVDRYYVTVYPLR----RRisRRTCAYIVAAIWLLSCGLALPAAAHTyYVE 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  88 SNQWGRSSCTINWPG--ESGAWYTGFiiyTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVT-----RM 160
Cdd:cd15394 143 FKGLDFSICEEFWFGqeKQRLAYACS---TLLITYVLPLLAISLSYLRISVKLRNRVVPGSMTQSQAEWDRARrrktfRL 219
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12652991 161 VSIVVAVFIFCWLPFYIFNVSSvsmAISPTPALKGMFDFVVVLTY----ANSCANPILYAFLSDNFKK 224
Cdd:cd15394 220 LVVVVVAFAICWLPLHIFNVIR---DIDIDLIDKQYFNLIQLLCHwlamSSACYNPFLYAWLHDSFRG 284
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
30-226 1.10e-18

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 83.44  E-value: 1.10e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  30 FTSIFCLTVMSIDRYLAVVHPIKSAKWRrPRTAKMITMAVWGVSL-LVILPIMIYAGLRSNQWGRSSCTINWPGESG-AW 107
Cdd:cd14980  93 LMSVLMMLLITLDRYICIVYPFSNKRLS-YKSAKIILILGWLFSIiFAAIPILYSINQPGDNRLYGYSSICMPSNVSnPY 171
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 108 YTGFIIYTFILGFLVPLtIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIfCWLPFYIFNVSSV--SM 185
Cdd:cd14980 172 YRGWLIAYLLLTFIAWI-IICILYILIFISVRKSRKSARRSSSKRDKRIAIRLALILITDLI-CWLPYYIVIFSGLltST 249
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 12652991 186 AISPTpALKgmfdFVVVLTYA-NSCANPILYAFLSDNFKKSF 226
Cdd:cd14980 250 EIDIH-VLQ----FIAILALPlNSAINPYLYTLTTPTFKRDF 286
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
10-226 1.42e-18

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 83.05  E-value: 1.42e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWgvslLVILPIMIYAGLRSN 89
Cdd:cd15155  64 HWPFGDSLCKISGTAFLTNIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVW----ILVLSGGISASLFST 139
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINWPGESGAWYTGFI----IYTFILGFLVPLTIICLCYLFIIIKVKSSgirVGSSKRKKSEKKVTRMVSIVV 165
Cdd:cd15155 140 TNVSNTSTTCFEGFSKSIWKTYLskitIFIEVVGFIIPLLLNLTCSSLVLRTLRKP---ATLSQIGTNKEKVLKMILVHV 216
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 166 AVFIFCWLPF------YIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15155 217 AIFVVCFVPYnsilflYALVRSQAIANCGVERFARTMYPITLCLATLNCCFDPFVYYFTSESFQKSF 283
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
10-223 1.59e-18

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 84.29  E-value: 1.59e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI--------M 81
Cdd:PHA02638 160 QWIFGDFMCKVISASYYIGFFSNMFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPAyfifeasnI 239
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   82 IYAGLRSNQW-GRSSCTINWPGESGAWYTGFIIYTF---ILGFLVPLTIICLCYLFIIIKVKSsgirvgssKRKKSEKKV 157
Cdd:PHA02638 240 IFSAQDSNETiSNYQCTLIEDNEKNNISFLGRILQFeinILGMFIPIIIFAFCYIKIILKLKQ--------LKKSKKTKS 311
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991  158 TRMVSIVVAVFIFCWLPFYI-------FNVSSVSMAISPTPALKGMFDFVVVLTYANS----CANPILYAFLSDNFK 223
Cdd:PHA02638 312 IIIVSIIIICSLICWIPLNIvilfatmYSFKGFNSIISEHICGFIKLGYAMMLAEAISlthcCINPLIYTLIGENFR 388
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
11-226 1.79e-18

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 82.95  E-value: 1.79e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRprTAKMITMAVWGVSLLVILPIMIYAGLR--- 87
Cdd:cd15399  66 WKFGAVLCHLVPYAQALAVHVSTVTLTVIALDRHRCIVYHLESKISKK--ISFLIIGLTWAASALLASPLAIFREYSvie 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  88 -SNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVK---SSGirVGSSKRKKSEKKVTRMVSI 163
Cdd:cd15399 144 iSPDFKIQACSEKWPNGTLNDGTIYSVSMLLIQYVLPLAIISYAYIRIWTKLKnhvSPG--GGNDHYHQRRRKTTKMLVC 221
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12652991 164 VVAVFIFCWLPFYIFNVSS-VSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15399 222 VVVVFAVSWLPFHAFQLASdIDSKVLDLKEYKLIYTIFHVIAMCSTFANPLLYGWMNNNYRTAF 285
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
11-226 1.87e-18

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 82.53  E-value: 1.87e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWgvslLVILPIMIYAGLRSNQ 90
Cdd:cd15199  66 WSLGGGTCKALLFMLSLSRGVSIAFLTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVW----LLLVGLTIPTLLASQP 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKvtrMVSIVVAVFIF 170
Cdd:cd15199 142 KNFTECNSFSPKDDEDFSDTWQEAVFFLQFLLPFGLIVFCTVRIIRRLKKRLRDVGKQPKLQRAMA---LVTSVVVVFGF 218
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 171 CWLP-------FYIFNVSSVSMAISptpALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15199 219 CFLPcflarvlMLIFQNKESCNALN---IAVHTYDVTMCLTYLNSVLDPIVYCFSSPTFRSSY 278
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
11-226 1.87e-18

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 82.48  E-value: 1.87e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIyaglrsnQ 90
Cdd:cd15060  66 WLFGIHLCQMWLTCDILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLI-------G 138
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WgrssctINWPGESG-------AWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirvgsskrkkseKKVTRMVSI 163
Cdd:cd15060 139 W------NDWPENFTettpctlTEEKGYVIYSSSGSFFIPLLIMTIVYVKIFIATSKE-------------RRAARTLGI 199
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12652991 164 VVAVFIFCWLPFYIFNVS-SVSMAISPTPALKgmfDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15060 200 IMGVFVVCWLPFFLMYVIlPFCETCSPSAKVV---NFITWLGYVNSALNPVIYTIFNLDFRRAF 260
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
3-226 1.92e-18

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 82.33  E-value: 1.92e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   3 AMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMI 82
Cdd:cd15330  58 ALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPML 137
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  83 YAGLRSNQWGRSSCTINWPgesgawyTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVgsskrkksekkvtRMVS 162
Cdd:cd15330 138 GWRTPEDRSDPDACTISKD-------PGYTIYSTFGAFYIPLILMLVLYGRIFKAAARERKTV-------------KTLG 197
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 163 IVVAVFIFCWLPFYI------FNVSSVSMaisptPALkgMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15330 198 IIMGTFILCWLPFFIvalvlpFCESTCHM-----PEL--LGAIINWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
11-226 1.96e-18

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 82.32  E-value: 1.96e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIK----SAKWRRPRTAKMITmAVWGVSLLVILPIMIYAGL 86
Cdd:cd15310  67 WNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHyqhgTGQSSCRRVSLMIT-AVWVLAFAVSCPLLFGFNT 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  87 RSNQwgrSSCTINWPGesgawytgFIIYTFILGFLVPLTIICLCYLFIIIkvkssgirvgsskRKKSEKKVTRMVSIVVA 166
Cdd:cd15310 146 TGDP---TVCSISNPD--------FVIYSSVVSFYLPFGVTLLVYVRIYV-------------VLLREKKATQMLAIVLG 201
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 167 VFIFCWLPFY---IFNVSSVSMAISPtpalkGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15310 202 AFIVCWLPFFlthILNTHCQACHVPP-----ELYSATTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
11-226 2.65e-18

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 82.29  E-value: 2.65e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKsakwrrPR----TAKMITMAVWGVSLLVILPIMIYAGL 86
Cdd:cd16003  66 WYFGEAYCRFHNFFPITSVFASIYSMTAIAVDRYMAIIDPLK------PRlsatATKVVIGSIWILAFLLAFPQCLYSKT 139
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  87 RSNQwGRSSCTINWPGESGAWYTGFIIyTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSS----KRKKSEKKVTRMVS 162
Cdd:cd16003 140 KVMP-GRTLCFVAWPGGPDQHFTYHII-VIVLVYCLPLLVMGITYTIVGITLWGGEIPGDTSdkyhEQLRAKRKVVKMMI 217
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12652991 163 IVVAVFIFCWLPFYI-FNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd16003 218 IVVLTFAICWLPYHIyFIVTGLYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
1-226 3.28e-18

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 81.50  E-value: 3.28e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILP 79
Cdd:cd15327  56 FSATLEVLGFWAFGRVFCDIWAAVDVLCCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVIsIGP 135
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  80 IMIYAglRSNQWGRSSCTINWPgesgawyTGFIIYTFILGFLVPLTIICLCYLFI-IIKVKSSGIRvgsskrkksekKVT 158
Cdd:cd15327 136 LLGWK--EPPPPDESICSITEE-------PGYALFSSLFSFYLPLMVILVMYFRVyVVALKFSREK-----------KAA 195
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 159 RMVSIVVAVFIFCWLPFY-IFNVSSVSMAISPTpalKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15327 196 KTLAIVVGVFILCWFPFFfVLPLGSFFPALKPS---EMVFKVIFWLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
29-226 4.04e-18

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 81.91  E-value: 4.04e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  29 QFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ-WGRSSCTINWPGESGAW 107
Cdd:cd14978  88 QTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECEnCNNNSYYYVIPTLLRQN 167
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 108 YTGFIIY----TFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKK--------VTRMVSIVVAVFIFCWLPF 175
Cdd:cd14978 168 ETYLLKYyfwlYAIFVVLLPFILLLILNILLIRALRKSKKRRRLLRRRRRLLSrsqrrerrTTIMLIAVVIVFLICNLPA 247
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 12652991 176 YIFNV-SSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd14978 248 GILNIlEAIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
11-224 4.50e-18

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 81.72  E-value: 4.50e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYaGLRSNQ 90
Cdd:cd15158  66 WLFGDFLCRISSYALYVNLYCSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSPFLMS-GSHDTE 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCtINWPGESGAWYTGFIIYTF--ILGFLVPLTIICLCYLFIIIKVKSSGIRVgsSKRKKSEKKVTRMVSIVVAVF 168
Cdd:cd15158 145 TNKTKC-FEPPQSNQQLTKLLVLNYIslVVGFIIPFLVILICYAMIIRTLLKNTMKA--RKQQSSRKKAIRMIIIVLLAF 221
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12652991 169 IFCWLPFYI---FNVSSVSMAISPTPALKGMFDFVVV---LTYANSCANPILYAFLSDNFKK 224
Cdd:cd15158 222 LVSFMPYHIqrtIHLHFLSRKDSTCEEVLYMQKSVVItlcLAAANCCFDPLLYFFSGENFRR 283
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
4-226 6.25e-18

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 81.57  E-value: 6.25e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   4 MQVALVH------WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVI 77
Cdd:cd14997  54 MPVALVEtwarepWLLGEFMCKLVPFVELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTS 133
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  78 LPIMIYAGLRSNQWGRSS----CTINwpgESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKV------KSSGIRVGS 147
Cdd:cd14997 134 SPVLFITEFKEEDFNDGTpvavCRTP---ADTFWKVAYILSTIVVFFVVPLAILSGLYSVICRRLvghpalESRRADAAN 210
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 148 SKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFnvsSVSMAISPTPALKGM--------FDFVVVLTYANSCANPILYAFLS 219
Cdd:cd14997 211 RHTLRSRRQVVYMLITVVVLFFVCLLPFRVV---TLWIIFAPDEDLQALglegylnlLVFCRVMVYLNSALNPILYNLMS 287

                ....*..
gi 12652991 220 DNFKKSF 226
Cdd:cd14997 288 TKFRSAF 294
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
7-225 7.22e-18

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 81.20  E-value: 7.22e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   7 ALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRpRTAKMITMAvWGVSLLVILPIMIYAGL 86
Cdd:cd15382  63 ATVAWLAGDFLCRLMLFFRAFGLYLSSFVLVCISLDRYFAILKPLRLSDARR-RGRIMLAVA-WVISFLCSIPQSFIFHV 140
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  87 RSN---QWGRSSCTINWpGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTR---- 159
Cdd:cd15382 141 ESHpcvTWFSQCVTFNF-FPSHDHELAYNIFNMITMYALPLIIIVFCYSLILCEISRKSKEKKEDVSEKSSSVRLRrssv 219
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 160 ------------MVSIVVAVFIFCWLPFYIFNVSSV---SMAISPTPAL-KGMFDFVVvltyANSCANPILYAFLSDNFK 223
Cdd:cd15382 220 gllerarsrtlkMTIVIVLVFIICWTPYFIMSLWYWfdrESASKVDPRIqKGLFLFAV----SNSCMNPIVYGYFSIDLR 295

                ..
gi 12652991 224 KS 225
Cdd:cd15382 296 RE 297
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
11-226 8.68e-18

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 80.59  E-value: 8.68e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRsnQ 90
Cdd:cd14988  66 WLWGSFLCKFTHYFYFANMYSSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIRRALCAGIWVLSAIIPLPEVVHMQLL--D 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTINWPGES-GAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGirvgsskrKKSEKKVTRMVSIVVAVFI 169
Cdd:cd14988 144 GVEPMCLFLAPFETyDEWALAVSLLTLIIGFLIPFSIIAVFNVLTARYIRTAG--------RPESRRHCLLIYAYILVFV 215
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 170 FCWLPFYI------FNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd14988 216 VCWLPYHVtlllltLHGSHISLHCNLVHFLYFFYDVIDCFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
9-226 9.86e-18

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 80.87  E-value: 9.86e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   9 VHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRpRTAKMITMAvWGVSLLVILPIMIYAGLRS 88
Cdd:cd15383  65 VQWYAGDLACRLLMFLKLFAMYSSAFVTVVISLDRHAAILNPLAIGSARR-RNRIMLCAA-WGLSALLALPQLFLFHTVT 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWG--------RSSCTINWPGesgawyTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVT-- 158
Cdd:cd15383 143 ATPPvnftqcatHGSFPAHWQE------TLYNMFTFFCLFLLPLLIMIFCYTRILLEISRRMKEKKDSAKNEVALRSSsd 216
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 159 ----------RMVSIVVAVFIFCWLPFY---IFNVSSVSMAISPTP-ALKGMFdFVVVLTyaNSCANPILYAFLSDNFKK 224
Cdd:cd15383 217 nipkarmrtlKMTIVIVSSFIVCWTPYYllgLWYWFSPEMLEQTVPeSLSHIL-FLFGLL--NACLDPLIYGLFTISFRR 293

                ..
gi 12652991 225 SF 226
Cdd:cd15383 294 GL 295
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
11-222 1.48e-17

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 80.20  E-value: 1.48e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd15200  66 WRFGATACQVNLFMLSMNRTASIVFLTAIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNIHLLLLDHVQSNS 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTINWPGESGAWYTGFiiytFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSekkvtRMVSIVVAVFIF 170
Cdd:cd15200 146 TCLSYDHGTDPSASDRWHRIL----FFLEFFLPLGIILFCIFSIILTLKQRKLAKQAGPQRAV-----KVLAVIVLVYTV 216
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 171 CWLPFYIFNVSS-VSMAISPTPALKGM---FDFVVVLTYANSCANPILYAFLSDNF 222
Cdd:cd15200 217 CFLPSILFALASlVAFKVSQCRSLDLCtqlFHGSLAFTYLNSALDPVLYCFSSPSF 272
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
1-226 1.63e-17

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 79.94  E-value: 1.63e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILP 79
Cdd:cd15325  56 FSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVIsIGP 135
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  80 imIYAGLRSNQWGRSSCTINWPgesgawyTGFIIYTFILGFLVPLTIICLCYLFI-IIKVKSSGIRvgsskrkksekKVT 158
Cdd:cd15325 136 --LFGWKEPAPEDETICQITEE-------PGYALFSALGSFYLPLAIILVMYCRVyVVALKFSREK-----------KAA 195
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 159 RMVSIVVAVFIFCWLPFY-IFNVSSVSMAISPTPALkgmFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15325 196 KTLGIVVGCFVLCWLPFFlVMPIGSIFPAYKPSDTV---FKITFWLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
10-225 2.00e-17

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 79.90  E-value: 2.00e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILP-IMIYAGLRS 88
Cdd:cd15156  64 NWPFGDLLCKISVTLFYTNMYGSILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPaSFFQSTNNQ 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRSSCTINWPGESGAWY-TGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirVGSSKRKKSEKKVTRMVSIVVAV 167
Cdd:cd15156 144 LNNNSETCFENFSSKTWKTYlSKIVIFIEIVGFFIPLILNVTCSTMVLKTLRRP---NTLSRSKLNKKKVLKMIFVHLFI 220
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12652991 168 FIFCWLP------FYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15156 221 FCFCFIPynvnlvLYSLVRTQTFKNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFTSETIQNS 284
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
11-220 2.22e-17

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 79.80  E-value: 2.22e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd16001  66 WPFGDFLCKLVRFLFYTNLYGSILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTLVYARTGSIN 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 wGRSSC-TINWPGESGAWYTGFIIYTFiLGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKvtRMVSIVVAVFI 169
Cdd:cd16001 146 -NRTVCyDLTSPDNFGNYFPYGMVLTV-TGFLIPFLIILLCYCLMIKSLIRSEEAAGVGKAARAKSI--RTILLVCGLFA 221
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 170 FCWLPFYIFNVSSVSM---AISPTPALKGMFDFVVV---LTYANSCANPILYaFLSD 220
Cdd:cd16001 222 LCFVPFHITRTIYLFVrvyLVQDCPLLQFVSLAYKIwrpLVSFNSCINPLLY-FLSG 277
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
10-224 3.48e-17

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 79.47  E-value: 3.48e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPiksAKWR-RPRTAKMITMAVWGVSLLVILPIMIYAGL-- 86
Cdd:cd15395  65 HWVFGEAMCKLNSMVQCISITVSIFSLVLIAIERHQLIINP---RGWRpNNRHAYVGIAVIWVLAVLTSLPFLIFQVLtd 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  87 -----RSNQW----GRSSCTINWPGESG--AWYTGFiiytFILGFLVPLTIICLCYLFIIIKVKSSG-----IRVGSSKR 150
Cdd:cd15395 142 epfknVNVSLdaykGKYVCLDQFPSDTIrlSYTTCL----LVLQYFGPLCFIFICYLKIYIRLKRRNnmmdkMRDNKYRS 217
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12652991 151 KKSEKKVTRMVSIVVAvFIFCWLPFYIFN-VSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15395 218 SETKRINIMLISIVVA-FAVCWLPLNIFNaVFDWNHEAIATCNHNLLFLICHLTAMISTCVNPIFYGFLNKNFQR 291
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
10-226 3.59e-17

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 78.90  E-value: 3.59e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMI----YAG 85
Cdd:cd15049  65 YWPLGPLLCDLWLALDYVASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAILgwqyFVG 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  86 LRSNQWGRssCTINWPGESgawytGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirvgsskrkkseKKVTRMVSIVV 165
Cdd:cd15049 145 ERTVPDGQ--CYIQFLDDP-----AITFGTAIAAFYLPVLVMTILYWRIYRETARE-------------RKAARTLSAIL 204
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 166 AVFIFCWLPfyiFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15049 205 LAFIITWTP---YNILVLVSTFCAKCIPDTLWSFGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
1-227 3.68e-17

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 78.84  E-value: 3.68e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd15334  56 FSIMYIVKETWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPP 135
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLRSNQwgRSSCTINWPgesgawYTGFIIYTFILGFLVPLTIICLCYlFIIIKVKSSGIRVGSSkrkksekkvtrm 160
Cdd:cd15334 136 LFWRHQTTSR--EDECIIKHD------HIVFTIYSTFGAFYIPLALILILY-YKIYRAATRERKAATT------------ 194
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 161 VSIVVAVFIFCWLPFYIFNVssVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQ 227
Cdd:cd15334 195 LGLILGAFVICWLPFFVKEV--IVNTCDSCYISEEMSNFLTWLGYINSLINPLIYTIFNEDFKKAFQ 259
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
1-226 4.34e-17

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 79.05  E-value: 4.34e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd15205  56 FTLLQNISSNWLGGAFMCKMVPFVQSTAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPM 135
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 M-------IYAGLRSNQWgrSSCTINWPG-ESGAWYTGFIIytfILGFLVPLTIICLCYLFIIIK-----------VKSS 141
Cdd:cd15205 136 LfvqqlevKYDFLYEKRH--VCCLERWYSpTQQKIYTTFIL---VILFLLPLTTMLFLYSRIGYElwikkrvgdasVLQT 210
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 142 GIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVS---SVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFL 218
Cdd:cd15205 211 IHGIEMSKISRKKKRAVKMMVTVVLLFAVCWAPFHVVHMMieySNLENKYDGVTIKLIFAIVQLIGFSNSFNNPIVYAFM 290

                ....*...
gi 12652991 219 SDNFKKSF 226
Cdd:cd15205 291 NENFKKNF 298
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
11-226 6.26e-17

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 78.35  E-value: 6.26e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKsakwrrPR----TAKMITMAVWGVSLLVILPIMIYAGL 86
Cdd:cd16004  66 WYFGLEFCRFQNFFPITAMFVSIYSMTAIAADRYMAIIHPFK------PRlsagSTKVVIAGIWLVALALAFPQCFYSTV 139
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  87 RSNQwGRSSCTINWPGESGAWYT-GFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGI-----RVGSSKRKKSEKKVTRM 160
Cdd:cd16004 140 TMDQ-GRTKCIVAWPGDSGGKHQlTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAVpghqaHGAYHRQLQAKKKFVKT 218
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 161 VSIVVAVFIFCWLPFYI-FNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd16004 219 MVVVVVTFAICWLPYHLyFILGSFNEDIYCQKYIQQVYLAIFWLAMSSTMYNPIIYCCLNQRFRSGF 285
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
30-226 7.02e-17

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 78.66  E-value: 7.02e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  30 FTSIFCLTVMSIDRYLAVVHPIKsAKWRRPRT-AKMITMAVWGVSLLVILPIMIYAGLRSNQ-------WGRSSCTINWP 101
Cdd:cd15358  86 FASILNVTALSVERYIAVVHPLK-AKYVVTRThAKRVIGAVWVVSILCSIPNTSLHGIFQLTvpcrgpvPDSATCMLVKP 164
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 102 gesgAWYTGFII-YTFILGFLVPLTIICLCYLFI-----------IIKVKSSGI-----RVGSSKRKKSEKKVTRMVSIV 164
Cdd:cd15358 165 ----RWMYNLIIqITTLLFFFLPMGTISVLYLLIglqlkrekmllVLEAKGSKAgdsyqHRRIQQEKRRRRQVTKMLFVL 240
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 165 VAVFIFCWLPFYIFNVSSvSMAISPTPALKGMFDFVVVLT----YANSCANPILYAFLSDNFKKSF 226
Cdd:cd15358 241 VVVFGICWAPFHTDRLMW-SFISQWTGELHLAFQYVHIISgvffYLSSAANPVLYNLMSTRFREMF 305
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
10-226 8.54e-17

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 77.98  E-value: 8.54e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSakwRRPRTA-KMITMAVWGVSLLVILPIMIYAGLRS 88
Cdd:cd16002  65 EWYYGLEYCKFHNFFPIAAVFASIYSMTAIALDRYMAIIHPLQP---RLSATAtKVVICVIWVLAFLLAFPQGYYSDTEE 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 nQWGRSSCTINWPGESGAWY-TGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGI------RVGSSKRKKSEkkVTRMV 161
Cdd:cd16002 142 -MPGRVVCYVEWPEHEERKYeTVYHVCVTVLIYFLPLLVIGCAYTVVGITLWASEIpgdssdRYHEQVSAKRK--VVKMM 218
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 162 SIVVAVFIFCWLPFYI-FNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd16002 219 IVVVCTFAICWLPYHIyFLLQYFHPELYEQKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRVGF 284
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
4-226 9.34e-17

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 77.88  E-value: 9.34e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   4 MQVALVH--WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIM 81
Cdd:cd15367  57 LQYVLQHdnWTYSELLCKICGILLYENIYISIGFLCCISVDRYLAVVHPFRFHAFRTMKAATLVSTVIWLKELMTCVFFF 136
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  82 IYAGLRSNQWGRSSCTINWPGEsgAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKV-KSSGIRvgsskrKKSEKKVTRM 160
Cdd:cd15367 137 LHGEISKDKENHSVCFEHYPIK--AWEHNINYYRFYAGFLFPIFLLSFSYCRILRAVrKSHGTQ------KSQKIQIKRL 208
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12652991 161 VSIVVAVFIFCWLPFYIFNV--SSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15367 209 VLSTVVIFLVCFGPYHILLLvrSVFERDCNFAEGIFNYYHFSLLLTSFNCVADPVLYCFASESTYHDF 276
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
10-223 1.02e-16

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 77.91  E-value: 1.02e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRpRTAKMITMAVWGVSLLVILPIMIyagLRS- 88
Cdd:cd15153  64 TWPFGRFLCLLCFYLKYLNMYASICFLTCISIQRCFFLLHPFKARDWKR-RYDVGISAAVWIVVGLACLPFPL---LRSk 139
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 -NQWGRSSCTINWPGE--SGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRvgsSKRKKSEKKVTRMVSIVV 165
Cdd:cd15153 140 sLSNNNRSCFADLGMKklNFGAAIAMMTVAELFGFVIPLFIIAWCTWKTENSLRQRNKQ---QQSTSEKQKALRMVRMCA 216
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12652991 166 AVFIFCWLPFYI---FNVSSVSMAISPTPALKGMFDF---VVVLTYANSCANPILYAFLSDNFK 223
Cdd:cd15153 217 AVFFICFAPYHInflFYLMVSESIITNCEVSQVILQFhpiSLCLASLNCCLDPILYYFMTSEFQ 280
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
30-226 1.08e-16

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 77.95  E-value: 1.08e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  30 FTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQW---GRSSCTINWPgesgA 106
Cdd:cd15133  86 LASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPNTSLHGIKFLGSgvpASAQCTVRKP----Q 161
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 107 WYTGFII-YTFILGFLVPLTIICLCYLFIIIKVK------------SSGIRVGSSKR-KKSEKKVTRMVSIVVAVFIFCW 172
Cdd:cd15133 162 AIYNMIPqHTGHLFFVLPMAVISVLYLLMALRLArergldatgagsKIGTRTGQLLQhPRTRAQVTKMLFILVVVFAICW 241
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 173 LPFYIFNV--SSVSmaiSPTPALKGMFDFVVVLT----YANSCANPILYAFLSDNFKKSF 226
Cdd:cd15133 242 APFHIDRLmwSFIS---DWTDNLHEVFQYVHIISgvffYLSSAVNPILYNLMSTRFREMF 298
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
11-226 1.09e-16

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 77.67  E-value: 1.09e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIK-SAKWRRPRTAKMITMAvWGVSLLVILpIMIYAGLrsN 89
Cdd:cd15314  66 WYFGDLFCKIHSSFDITLCTASILNLCFISIDRYYAVCQPLLyRSKITVRVVLVMILIS-WSVSALVGF-GIIFLEL--N 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINWPGESGAWYTGFI-IYTFILGFLVPLTIICLCYL--FIIIKVKSSGIRVGSSKRKKSEKK----VTRMVS 162
Cdd:cd15314 142 IKGIYYNHVACEGGCLVFFSKVSsVVGSVFSFYIPAVIMLCIYLkiFLVAQRQARSIQSARTKSGASSSKmerkATKTLA 221
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12652991 163 IVVAVFIFCWLPFYIFNVSSVSMAISPTPALkgmFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15314 222 IVMGVFLLCWTPFFLCNIIDPFINYSIPPVL---IEVLNWLGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
2-230 1.18e-16

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 77.64  E-value: 1.18e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   2 LAMQVALVH------WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLL 75
Cdd:cd15305  52 LVMPVSLIAilydyaWPLPRYLCPIWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIG 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  76 VILPIMIyAGLRSNQ--WGRSSCTINWPgesgawytGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirvgssKRKKS 153
Cdd:cd15305 132 ISMPIPV-IGLQDDEkvFVNGTCVLNDE--------NFVLIGSFVAFFIPLIIMVITYCLTIQVLQRQ-------QAINN 195
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12652991 154 EKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPAL-KGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVL 230
Cdd:cd15305 196 ERRASKVLGIVFFLFLIMWCPFFITNILSVLCKEACDQKLmEELLNVFVWVGYVSSGINPLVYTLFNKTYRRAFSNYI 273
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
1-226 1.31e-16

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 77.24  E-value: 1.31e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILP 79
Cdd:cd15326  56 FSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVIsIGP 135
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  80 IMIYAGLRSNQwgRSSCTINwpgeSGAWYTgfiIYTFILGFLVPLTIICLCYLFI-IIKVKSSGIRvgsskrkksekKVT 158
Cdd:cd15326 136 LLGWKEPAPPD--DKVCEIT----EEPFYA---LFSSLGSFYIPLIVILVMYCRVyIVALKFSREK-----------KAA 195
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 159 RMVSIVVAVFIFCWLPFYI-FNVSSVSMAISPTPALkgmFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15326 196 KTLGIVVGMFILCWLPFFIaLPLGSLFSHLKPPETL---FKIIFWLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
1-226 1.31e-16

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 77.28  E-value: 1.31e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALV------HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSL 74
Cdd:cd15304  51 FLVMPVSMLtilygyRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISV 130
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  75 LVILPIMIYaGLR--SNQWGRSSCTINwpgesgawYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirvgsskrKK 152
Cdd:cd15304 131 GISMPIPVF-GLQddSKVFKEGSCLLA--------DENFVLIGSFVAFFIPLTIMVITYFLTIKSLQQS---------IS 192
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12652991 153 SEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKG-MFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15304 193 NEQKASKVLGIVFFLFVVMWCPFFITNVMAVICKESCNEVVIGgLLNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
10-226 1.33e-16

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 77.42  E-value: 1.33e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd15967  65 KWIFGQVFCKITRFCFNLNLYGSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSLPDLFFSKTNSN 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINWPGESGAWYTgfIIYTFIlGFLVPLTIICLCY-LFIIIKVKSSGIRVGSSKRKKsekkvtRMVSIVVAVF 168
Cdd:cd15967 145 GTKCFDTTFNDYLESYLTYS--LGWTVT-GFVIPLLIILGCYgHVVVVLCRNNNVDKGLKQRCL------KLVIILIVLF 215
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 169 IFCWLPFYIF-NVSSVSMAISPTPALKGMFDFVVV-------LTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15967 216 SVCYIPYHVFrNLNLLSRILQKQGSCTQWFRGIYIahqvsrgLVCLNSALNPLVYLMGSEDILSRI 281
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
7-226 1.48e-16

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 77.50  E-value: 1.48e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   7 ALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIY--- 83
Cdd:cd15154  61 ANHYWPFGNFLCQFSGSIFQMNMYGSCLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVPAAIVhss 140
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  84 AGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKV----KSSGIRVGsskrkksekKVTR 159
Cdd:cd15154 141 SDCLLHGEKVYRCFESFSDNDWKGLLPLVVLAEILGFLLPLAAVLYCSCRIFVELcrtqEPQQGRRR---------KTVR 211
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12652991 160 MVSIVVAVFIFCWLPF------YIFNVSSVSMAISPT-PALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15154 212 LLLVNLVIFLICFVPYnttlavYGLLRANLVEDTWNIkDTLRKVLSVTVLLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
11-217 1.53e-16

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 77.53  E-value: 1.53e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd15366  66 WIHGPESCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEIGANSAPLFHDELFRDR 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTINWPGESgaWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirvgSSKRKKSEKKVTRMVSIVVAVFIF 170
Cdd:cd15366 146 YNHTFCFEKYPMED--WVAWMNLYRVFVGFLFPWVLMLFSYRGILRAVRGN-----VSTEQQEKAKIKRLALSLIAIVLL 218
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 12652991 171 CWLPFYIFNVS-SVSMAISPTPALKGMFDFV-----VVLTYANSCANPILYAF 217
Cdd:cd15366 219 CFAPYHVLLLSrSVVYLGKPCDCGFEERVFTayhvsLALTSLNCVADPILYCL 271
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
11-225 1.96e-16

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 77.10  E-value: 1.96e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd15924  65 WQLRTFVCRVTSVLFYFTMYTSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFLLSLPNMILTNQQPRE 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCtINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVgSSKRKKSEKKVTRMVSIVVAVFIF 170
Cdd:cd15924 145 KNVKKC-SFLKSELGLKWHEIVNYICQVIFWIVFLLMIVCYTAITKKVYRSYRRV-FRSSSSRRKKSNVKIFIIVAVFFV 222
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 171 CWLPF------YIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15924 223 CFVPYhfaripYTLSQTRDVFDCTAENILFYVKEATLFLSALNVCLDPIIYFFLCKSFRES 283
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
10-224 2.20e-16

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 76.99  E-value: 2.20e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKwrRPRTAKMITMAVWGVSLLVILPIMIYAGLR-- 87
Cdd:cd15389  65 TWVFGKIMCHLSRFAQYCSVYVSTLTLTAIALDRHRVILHPLKPRI--TPCQGVVVIAIIWIMASCLSLPHAIYQKLVef 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  88 --SNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIrVGSSKRKKSEKKV------TR 159
Cdd:cd15389 143 eySNERTRSRCLPSFPEPSDLFWKYLDLATFILQYVLPLLIIGVAYTRVAKKLWLRNA-IGDVTTEQYVAQRrkkkktIK 221
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12652991 160 MVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALkgmFDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15389 222 MLMLVVLLFAICWLPLNCYHVLLSSHPIRSNSAL---FFAFHWLAMSSTCYNPFIYCWLNDSFRS 283
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
10-224 2.25e-16

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 76.80  E-value: 2.25e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd15186  63 EWGLHNAMCKLTTAFFFIGFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMFTKMKEN 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QwgrssCTINWPGE-SGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRvgsskrkkSEKKVTRMVSIVVAVF 168
Cdd:cd15186 143 E-----CLGDYPEVlQEIWPVLRNVELNFLGFLLPLLIMSYCYFRIIQTLFSCKNH--------KKARAIKLILLVVIVF 209
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12652991 169 IFCWLPF--YIFNVSSVSMAISPTPALKGMFDFVVVLT----YANSCANPILYAFLSDNFKK 224
Cdd:cd15186 210 FLFWTPYnvMIFLETLKLYDFFPSCDMKKDLRLALSVTetiaFSHCCLNPLIYAFAGEKFRR 271
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
9-226 2.64e-16

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 76.15  E-value: 2.64e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   9 VHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIyaglrs 88
Cdd:cd15210  64 QAWIHGETLCRVFPLLRYGLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWL------ 137
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRS-------SCTINwPGESGAWYTGFIiytFILGFLVPLTIICLCYlfiiikVKSSGIRVgsskrkksekkvTRMV 161
Cdd:cd15210 138 GIWGRFgldpkvcSCSIL-RDKKGRSPKTFL---FVFGFVLPCLVIIICY------ARREDRRL------------TRMM 195
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12652991 162 SIVVAVFIFCWLPFYIFNVssvsmaISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15210 196 LVIFLCFLVCYLPITLVNV------FDDEVAPPVLHIIAYVLIWLSSCINPIIYVAMNRQYRQAY 254
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
31-224 2.84e-16

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 76.47  E-value: 2.84e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  31 TSIFCLTVMSIDRYLAVVHPIksaKWRRP--RTAKMITMAVWGVSLLV-ILPIMIYAGLRsNQWGRSS-CT---INWPGE 103
Cdd:cd15137  93 VSVLILTLITLDRFICIVFPF---SGRRLglRRAIIVLACIWLIGLLLaVLPLLPWDYFG-NFYGRSGvCLplhITDERP 168
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 104 SGAWYTGFIiytFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFiFCWLPFYIFNVSSV 183
Cdd:cd15137 169 AGWEYSVFV---FLGLNFLAFVFILLSYIAMFISIRRTRKAAASRKSKRDMAVAKRFFLIVLTDF-LCWIPIIVIGILAL 244
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 12652991 184 S-MAISPTpalkgMFDFVVVLTYA-NSCANPILYAFLSDNFKK 224
Cdd:cd15137 245 SgVPIPGE-----VYAWVAVFVLPiNSALNPILYTLSTPKFRK 282
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
11-226 3.06e-16

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 76.23  E-value: 3.06e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHP-IKSAKWRRPRTAKMITMAVWGVSLLVILPIMIyaGLrsN 89
Cdd:cd15309  66 WRFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPmLYNTRYSSKRRVTVMISVVWVLSFAISCPLLF--GL--N 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINWPGesgawytgFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirvgsskrkkseKKVTRMVSIVVAVFI 169
Cdd:cd15309 142 NTDQNECIIANPA--------FVVYSSIVSFYVPFIVTLLVYVQIYIVLQKE-------------KKATQMLAIVLGVFI 200
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 170 FCWLPFYIFNVSSVSMAISPTPALKGMFDFvvvLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15309 201 ICWLPFFITHILNMHCDCNIPPALYSAFTW---LGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
11-224 3.30e-16

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 76.34  E-value: 3.30e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIY-AGLRSN 89
Cdd:cd15369  66 WLFGEAMCRVVTAAFYCNMYCSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLSeQTIQIP 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINWPGESGAWYTGFIIYTF-ILGFLVPLTIICLCYLFIIIKVKSSGIrvgsskrKKSEKKVTR---MVSIVV 165
Cdd:cd15369 146 DLGITTCHDVLNEQLLMGYYVYYFSIFsCLFFFVPLIITTVCYVSIIRCLSSSSD-------VANSSKKTRalfMAVAVF 218
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 166 AVFIFCWLPF-YIFNVSSVSMAISPTP-ALKGMFDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15369 219 CVFVICFGPTnVLLLAHYVRFAYTSTNdASYFAYLLCVCVGSISCCLDPLIYYYGSSQCQK 279
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
2-226 3.84e-16

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 76.02  E-value: 3.84e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   2 LAMQVALVH------WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLL 75
Cdd:cd15306  52 FVMPIALLTilfeamWPLPLVLCPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIG 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  76 VILPIMIyAGLRSNQWGRSSCTINWPGESgawYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIrvgsskrkKSEK 155
Cdd:cd15306 132 IAIPVPI-KGIETDVDNPNNITCVLTKER---FGDFILFGSLAAFFTPLAIMIVTYFLTIHALRKQTI--------TNEQ 199
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 156 KVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15306 200 RASKVLGIVFFLFLLMWCPFFITNITSVLCDSCNQTTLQMLMEIFVWIGYVSSGVNPLVYTLFNKTFRDAF 270
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
1-226 4.07e-16

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 75.99  E-value: 4.07e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILP 79
Cdd:cd15062  56 FSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVIsIGP 135
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  80 IMIYAGLRSNQwgRSSCTINWPgesgawyTGFIIYTFILGFLVPLTIICLCYLFI-IIKVKSSGIRvgsskrkksekKVT 158
Cdd:cd15062 136 LLGWKEPAPAD--EQACGVNEE-------PGYVLFSSLGSFYLPLAIILVMYCRVyVVAFKFSREK-----------KAA 195
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12652991 159 RMVSIVVAVFIFCWLPFYIfnVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15062 196 KTLGIVVGAFVLCWFPFFV--VLPLGSLFSTLKPPEPVFKVVFWLGYFNSCLNPIIYPCSSREFKRAF 261
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
11-224 4.82e-16

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 75.96  E-value: 4.82e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIkSAKWRRPRT---AKMITMAVWGVSLLVILPIMIYAGLR 87
Cdd:cd15175  64 WVFGEEMCKAVYCLYKMSFFSGMLLLMCISIDRYFAIVQAA-SAHRHRSRAvfiSKVSSLGVWVLAFILSIPELLYSGVN 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  88 SNQwGRSSCTINwPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKV-------KSSGIRVgsskrkksekkvtrm 160
Cdd:cd15175 143 NND-GNGTCSIF-TNNKQTLSVKIQISQMVLGFLVPLVVMSFCYSVIIKTLlqarnfeKNKAIKV--------------- 205
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 161 VSIVVAVFIFCWLPF-YIFNVSSVSMAISPTPA------LKGMFDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15175 206 IIAVVVVFVVFQLPYnSVMLVSTLSSFKGNTTDcdysknLDFALDVTYSLACFRCCLNPFLYAFIGVKFRN 276
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
32-226 5.92e-16

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 75.75  E-value: 5.92e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTG 110
Cdd:cd14968  85 SIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVgLTPMFGWNNGAPLESGCGEGGIQCLFEEVIPMDY 164
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 111 FIIYTFILGFLVPLTIICLCYLFI-------IIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSV 183
Cdd:cd14968 165 MVYFNFFACVLVPLLIMLVIYLRIfrvirkqLRQIESLLRSRRSRSTLQKEVKAAKSLAIILFLFALCWLPLHIINCITL 244
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 12652991 184 SMAISPTPALkgMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd14968 245 FCPECKVPKI--LTYIAILLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
11-226 7.44e-16

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 75.54  E-value: 7.44e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRS-N 89
Cdd:cd14977  66 WLFGDVMCKLVPFIQVTSLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLSTVAReS 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINWPGESGA----WYTGFIIYTFILGFLVPLTIICLCYLFI--IIKVKSSGIRVGSSKRKKSEKKVTRMVSI 163
Cdd:cd14977 146 SLDNSSLTVCIMKPSTPfaetYPKARSWWLFGCYFCLPLAFTAVCYLLMarTLIRAAKEYTRGTKKHMKQRRQLAKTVLC 225
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 164 VVAVFIFCWLPFYIFN----VSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd14977 226 LVLVFAFCWLPEHISNilraTLYNEVLIDTRSTLDILDLIGQFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
11-223 9.04e-16

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 75.22  E-value: 9.04e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd15928  66 WRFGDLLCRLMYFFSETCTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQ 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRS----SCTInWPGESGAWYTGFIIYTFIlgFLVPLTIICLCYLFIIIKVKSSGIR---VGSSKRKKSEKKVTRMVSI 163
Cdd:cd15928 146 GQQTprgfECTV-VNVSSGLLSVMLWVSTSF--FFVPMVCLSLLYGLIGRALWDRRQRsrtAGASRRDNNHRQTVRMLAV 222
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 164 VVAVFIFCWLPFYifnVSSVSMAISPTPALKGM-----FDFV-VVLTYANSCANPILYAFLSDNFK 223
Cdd:cd15928 223 IVLAFVLCWLPFH---VGRVIFNHSRASTKHLHyvsqyFNLVsFVLFYLSAAINPILYNLMSKRYR 285
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
30-226 9.68e-16

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 75.28  E-value: 9.68e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  30 FTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQW-------GRSSCTINWPg 102
Cdd:cd15357  86 FASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIPNTSIHGIKLQYFpngtlipDSATCTVVKP- 164
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 103 esgAWYTGFII-YTFILGFLVPLTIICLCYLFIIIKVK----SSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYI 177
Cdd:cd15357 165 ---LWIYNLIIqITSLLFYVLPMGVISVLYYLMGLKLRgdksLEADEMNVNIQRPSRKSVTKMLFVLVLVFAICWAPFHV 241
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 12652991 178 FNVsSVSMAISPTPALKGMFDFVVVLT----YANSCANPILYAFLSDNFKKSF 226
Cdd:cd15357 242 DRL-FFSFVVEWTEPLANVFNLIHVVSgvffYLSSAVNPIIYNLLSRRFRTAF 293
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
1-226 9.76e-16

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 75.47  E-value: 9.76e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALV-----HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLL 75
Cdd:cd15065  50 LLVMTFAVVndllgYWLFGETFCNIWISFDVMCSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSAL 129
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  76 V-ILPIMI---------YAGLRSNQWGRSSCTINWPgesgawYTGFIIYTFIlGFLVPLTIICLCY--LFIIIKVKSSGI 143
Cdd:cd15065 130 IsFLPIHLgwhrlsqdeIKGLNHASNPKPSCALDLN------PTYAVVSSLI-SFYIPCLVMLLIYsrLYLYARKHVVNI 202
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 144 RVGSSKRKKSEKKVT------------------RMVSIVVAVFIFCWLPFYIFNVSSvsmAISPTPALKGMFDFVVVLTY 205
Cdd:cd15065 203 KSQKLPSESGSKFQVpslsskhnnqgvsdhkaaVTLGIIMGVFLICWLPFFIINIIA---AFCKTCIPPKCFKILTWLGY 279
                       250       260
                ....*....|....*....|.
gi 12652991 206 ANSCANPILYAFLSDNFKKSF 226
Cdd:cd15065 280 FNSCLNPIIYSIFNSEFRRAF 300
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
7-224 1.36e-15

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 74.81  E-value: 1.36e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   7 ALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHpIKSAKWRRPRT---AKMITMAVWGVSLLVILPIMIY 83
Cdd:cd15177  60 TLQGWIFGNAMCKLIQGLYAINFYSGFLFLTCISVDRYVVIVR-ATSAHRLRPKTlfySVLTSLIVWLLSILFALPQLIY 138
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  84 AGLRSNQwGRSSCTINWP-GESGAWYTGFIIYTFILGFLVPLTIICLCYLFIiikvkssgIRVGSSKRKKSEKKVTRMVS 162
Cdd:cd15177 139 SRVENRS-ELSSCRMIFPeVVSRTVKGATALTQVVLGFAIPLIVMAVCYAAI--------GRTLLAARGWERHRALRVIA 209
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 163 IVVAVFIFCWLPFYI---------FNVSSVSMAISPTPALkgMFDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15177 210 ALVVAFVLFQLPYSVvllldtadlLATLELSCSQSKRKDI--ALLVTSGLAYVRCCLNPLLYAFVGVRFRR 278
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
11-220 1.53e-15

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 74.43  E-value: 1.53e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd15365  66 WTLSGFVCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICFNAVILTWEDSFHES 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTINWPGESgaWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGsskrkKSEKKVTRMVSIVVAVFIF 170
Cdd:cd15365 146 SSHTLCYDKFPLED--WQARLNLFRICLGYLLPLLIILFCYWKIYQAVRSNQATED-----QEKKKIFKLLLLITVTFVI 218
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 12652991 171 CWLPFYIFNVSSVSMAISPTPALKGMF---DFVVVLTYANSCANPILYAFLSD 220
Cdd:cd15365 219 CFTPYHVVLLIRSIVEPCDCRNAKWLYtlyKITVALTSLNCIADPFLYCFVTE 271
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
2-226 1.53e-15

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 74.45  E-value: 1.53e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   2 LAMQVALVH-----WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV 76
Cdd:cd15333  56 LVMPISIVYtvtgtWTLGQVVCDIWLSSDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISI 135
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  77 ILPIMIYAGLRSNQwGRSSCTINwpgESGAWYTgfiIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVgsskrkksekk 156
Cdd:cd15333 136 SLPPFFWRQAKAEE-EVSECVVN---TDHILYT---VYSTVGAFYIPTLLLIALYGRIYVEARARERKA----------- 197
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12652991 157 vTRMVSIVVAVFIFCWLPFYIFnvsSVSMAISPT--PALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15333 198 -TKTLGIILGAFIVCWLPFFII---SLVLPICKDacWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
10-230 2.17e-15

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 74.22  E-value: 2.17e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI-MIYAGLRS 88
Cdd:cd15307  65 HFPLSSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLsLMYSKDHA 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRSSCTINWPgesgawytGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGssKRKKSEKKVTRMVSIVVAVF 168
Cdd:cd15307 145 SVLVNGTCQIPDP--------VYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRSRHG--RIIRLEQKATKVLGVVFFTF 214
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12652991 169 IFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVL 230
Cdd:cd15307 215 VILWSPFFVLNLLPTVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVL 276
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
11-226 2.29e-15

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 73.68  E-value: 2.29e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYA----GL 86
Cdd:cd15063  66 WIFGHTWCQIWLAVDVWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWndgkDG 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  87 RSNQWGRSSCTINWPGESGawyTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirvgsskrkkseKKVTRMVSIVVA 166
Cdd:cd15063 146 IMDYSGSSSLPCTCELTNG---RGYVIYSALGSFYIPMLVMLFFYFRIYRAARME-------------TKAAKTVAIIVG 209
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 167 VFIFCWLPFYIFNVSSVSMAISPTPALkgmFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15063 210 CFIFCWLPFFTVYLVRAFCEDCIPPLL---FSVFFWLGYCNSALNPCIYALFSRDFRFAF 266
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
11-226 5.11e-15

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 73.42  E-value: 5.11e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKsakwRRPRTAKMITMA----VWGVSLLVILPIMIYAGL 86
Cdd:cd15123  66 WLFGRIGCKLLSFIQLTSVGVSVFTLTVLSADRYRAIVKPLE----LQTSDAVLKTCCkagcVWIVSMLFAIPEAVFSDL 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  87 RSNQWGRSSCTIN----WPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRV------GSSKRKKSEKK 156
Cdd:cd15123 142 YSFRDPEKNTTFEacapYPVSEKILQEIHSLLCFLVFYIIPLSIISVYYFLIARTLYKSTFNMpaeehsHARKQIESRKR 221
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 157 VTRMVSIVVAVFIFCWLP---FYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15123 222 VAKTVLVLVALFAFCWLPnhiLYLYRSFTYHTSVDSSAFHLIATIFSRVLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
11-224 5.18e-15

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 72.98  E-value: 5.18e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAglrSNQ 90
Cdd:cd15183  65 WIFGDAMCKFLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCLYFF---KSQ 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 W--GRSSCTINWPGESGAWYTGFIIYTF-ILGFLVPLTIICLCYLFIiikvkssgIRVGSSKRKKSEKKVTRMVSIVVAV 167
Cdd:cd15183 142 WefTHHTCSAHFPRKSLIRWKRFQALKLnLLGLILPLLVMIICYTGI--------INILLRRPNEKKAKAVRLIFVITLL 213
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 168 FIFCWLPFYIFNVSSVSMAISPTPA------LKGMFDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15183 214 FFLLWTPYNLAAFVSAFQDVLFTPSceqsqqLDLALQVTEVIAYTHCCVNPVIYVFVGERFRK 276
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
18-226 6.20e-15

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 72.68  E-value: 6.20e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  18 CRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWgvsLLVIlpIMIYAGLRSNQWGRSSCT 97
Cdd:cd15164  70 CLVLQSIYFINRYMSIYIITAIAVDRYIAIKYPLKAKSLRSPRKAALTCGLLW---VLVI--ISVSLRLAWEEQEENFCF 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  98 INWPGESGAWytgfIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRvgSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYI 177
Cdd:cd15164 145 GKTSTRPSKR----TLIFSLLGFFIPLIILSFCSIQVIRSLKKKKKT--NPHEEKLIQKAIYIVSANLIVFIVCFLPLHI 218
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 12652991 178 FNVSSVSM--AISPTPALKGMFDFVVV---LTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15164 219 GLLVRFVMesNKASCSLIQNIRNFIYVascLANANCCLDAICYYFVAKEFQEAS 272
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
11-226 6.95e-15

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 73.00  E-value: 6.95e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAkwRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd15980  66 WPFGSTVCKMSGMVQGISVSASVFTLVAIAVDRFRCIVYPFKQK--LTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEEK 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSS------------CTINWPGESGAwytgfIIYTFILG---FLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEK 155
Cdd:cd15980 144 NYRVVlgsqnktspvywCREDWPNQEMR-----KIYTTVLFaniYLAPLSLIVIMYARIGITLFKTAMPHTGKHNQEQRH 218
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 156 KVTR-------MVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALK---GMFDFVVVLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15980 219 VVSRkkqkvikMLLIVALLFILSWLPLWTLMMLSDYANLSPNQLQIiniYIYPFAHWLAFFNSSVNPIIYGFFNENFRRG 298

                .
gi 12652991 226 F 226
Cdd:cd15980 299 F 299
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
9-225 8.03e-15

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 72.46  E-value: 8.03e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   9 VHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRS 88
Cdd:cd15073  64 GSWKFGYAGCQWYAFLNIFFGMASIGLLTVVAVDRYLTICRPDLGRKMTTNTYTVMILLAWTNAFFWAAMPLVGWASYAL 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGrSSCTINWPgESGAWYTGFIIYTFILGFLVPLTIICLCYLFI---IIKVKSSGIRVGSSKRKKSEKKVTRMVSIVV 165
Cdd:cd15073 144 DPTG-ATCTINWR-KNDSSFVSYTMSVIVVNFIVPLAVMFYCYYNVsrfVKKVLASDCLESVNIDWTDQNDVTKMSVIMI 221
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 166 AVFIFCWLPFYIF-------NVSSVSMAISPTPALkgmfdfvvvLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15073 222 VMFLVAWSPYSIVclwasfgEPKKIPPWMAIIPPL---------FAKSSTFYNPCIYVIANKKFRRA 279
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
11-224 8.40e-15

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 72.48  E-value: 8.40e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAglRSNQ 90
Cdd:cd15184  64 WVFGNAMCKLLTGLYHIGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLPGIIFT--KSQK 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WG-RSSCTINWPGESGAWYTGFI-IYTFILGFLVPLTIICLCYLFIIIKVKSsgirvgsSKRKKSEKKVTRMVSIVVAVF 168
Cdd:cd15184 142 EGsHYTCSPHFPPSQYQFWKNFQtLKMNILGLVLPLLVMIICYSGILKTLLR-------CRNEKKRHKAVRLIFTIMIVY 214
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12652991 169 IFCWLPFYI------FNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15184 215 FLFWAPYNIvlllntFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPVIYAFVGEKFRS 276
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
11-224 1.01e-14

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 72.17  E-value: 1.01e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRsNQ 90
Cdd:cd15185  65 WVFGHGMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYETQ-EL 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTINWP-GESGAWYTGFIIYTFILGFLVPLTIICLCYLFIiikvkssgIRVGSSKRKKSEKKVTRMVSIVVAVFI 169
Cdd:cd15185 144 FEEFLCSPLYPeDTEDSWKRFHALRMNIFGLALPLLIMVICYTGI--------IKTLLRCPSKKKYKAIRLIFVIMVVFF 215
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 170 FCWLPFYI------FNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15185 216 IFWTPYNLvlllsaFQSIFFETDCERSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRK 276
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
10-225 1.18e-14

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 72.21  E-value: 1.18e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIksAKWRRPRTAKM---ITMAVWGVSLLVILPIMIYAGl 86
Cdd:cd15379  65 YWPFGDFTCRLVRFQFYTNLHGSILFLTCISVQRYLGICHPL--ASWHKKKGKKLtwlVCGAVWLVVIAQCLPTFVFAS- 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  87 RSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTII--CLCYLFIIIKVKSSGIRVGSSKRKKSEKKVtRMVSIV 164
Cdd:cd15379 142 TGTQRNRTVCYDLSPPARSTAYFPYGITLTRTGFLLPFAARlaCYCSMATILCRVVIAVAVVAAPGEKRGKAA-RMIIVV 220
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 165 VAVFIFCWLPF------YIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15379 221 AAVFLISFLPFhytktrYLQVRSWDGGPCTTRQAFAEAYKRTRPFASMNSVLDPILFYFTQSKFRPR 287
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
11-226 1.18e-14

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 72.12  E-value: 1.18e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMiYAGLRSNQ 90
Cdd:cd15209  66 WTLGQLHCQASGFIMGLSVIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVLPNF-FIGSLQYD 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTINWPGEsgawyTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTR---MVSIVVAV 167
Cdd:cd15209 145 PRIYSCTFAQTVS-----TVYTITVVVIHFLLPLLIVSFCYLRIWVLVLQVRQRVKPDQRPKLKPADVRnflTMFVVFVL 219
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 168 FIFCWLPfyiFNVSSVSMAISPTPAL----KGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15209 220 FAVCWAP---LNFIGLAVAINPKEMApkipEWLFVASYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
11-226 1.24e-14

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 72.29  E-value: 1.24e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPI----KSAKWRRPRTAkmitMAVWGVSLLVILPIMIYAGL 86
Cdd:cd15125  66 WMFGTVGCKLIPVIQLTSVGVSVFTLTALSADRYKAIVNPMdiqtSSAVLRTCLKA----IAIWVVSVLLAVPEAVFSEV 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  87 -RSNQWGRSSCT--INWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIK-VKSSGIRVGSSKRKKSEKKVTR--- 159
Cdd:cd15125 142 aHIMPDDNTTFTacIPYPQTDEMHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTlIKSAHNIPGEYSEHSKRQMETRkrl 221
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 160 --MVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVV--VLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15125 222 akIVLVFVGLFAFCWFPNHVLYMYRSFNYNEIDSSLGHMIVTLVarVLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
10-224 1.41e-14

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 72.08  E-value: 1.41e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPiksAKWR-RPRTAKMITMAVWGVSLLVILPIMIYAGLRS 88
Cdd:cd15397  65 YWIFGEVLCKMTPFIQCMSVTVSILSLVLIALERHQLIINP---TGWKpSVSQAYLAVVVIWMLACFISLPFLAFHILTD 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRSS-----------CTINWPGESGAwytgfIIYT---FILGFLVPLTIICLCYLFIIIKVKSSG----IRVGSSKR 150
Cdd:cd15397 142 EPYKNLShffapladkavCTESWPSEHHK-----LAYTtwlLLFQYCLPLLFILVCYLRIYLRLRRRKdmleRRGEYNRR 216
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12652991 151 KKSEKKVTRMVSIVVAVFIFCWLPFYIFN-VSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15397 217 AGHSKRINVMLVSLVAAFALCWLPLNVFNaIADWNHEAIPHCQHNLIFSLCHLAAMASTCVNPIIYGFLNSNFKK 291
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
10-225 2.13e-14

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 71.60  E-value: 2.13e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd15083  65 RWIFGKTGCDMYGFSGGLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRYVL 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINWPGESGA--WYtgfIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVT--------- 158
Cdd:cd15083 145 EGLLTSCSFDYLSRDDAnrSY---VICLLIFGFVLPLLIIIYCYSFIFRAVRRHEKAMKEMAKRFSKSELSspkarrqae 221
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12652991 159 ----RMVSIVVAVFIFCWLPFYIFNVSSVSmaiSPTPALKGMFDFV-VVLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15083 222 vktaKIALLLVLLFCLAWTPYAVVALIGQF---GYLEVLTPLATAIpAAFAKTSAIYNPVIYAFSHPKFRRA 290
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
10-226 2.73e-14

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 70.88  E-value: 2.73e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVD--GINqfTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLR 87
Cdd:cd14995  67 SWIYGYAGCLLITYLQylGIN--ASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFLLDLS 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  88 SNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirvgsskrkksEKKVTRMVSIVVAV 167
Cdd:cd14995 145 IKHYGDDIVVRCGYKVSRHYYLPIYLADFVLFYVIPLLLAIVLYGLIGRILFSS------------RKQVTKMLAVVVVL 212
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 168 FIFCWLPFYIFNVssVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd14995 213 FALLWMPYRTLVV--YNSFASPPYLDLWFLLFCRTCIYLNSAINPILYNLMSQKFRAAF 269
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
27-223 3.05e-14

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 71.01  E-value: 3.05e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  27 INQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVIL-------------PIMIYAGLRSNQWgr 93
Cdd:cd14989  80 INMYSSIFFLTWMSFDRYIALAKVMKSSPLRTMQHARLSCGLIWMASISATLlpftavqaqhtgeVHFCFADVREIQW-- 157
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  94 ssctinwpgesgawytgfiiYTFILGFLVPLTIICLCYLFII-IKVKSSGIRvgssKRKKSEKKVTRMVSIVVAVFIFCW 172
Cdd:cd14989 158 --------------------LEVTLGFIIPFSIIGLCYSLIVrVLVRAQKHR----RLRPRRQKALRMILVVVLVFFICW 213
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12652991 173 LPFYIFnvSSVSMAISPTPALKG-----------MFDFVVVLTYANSCANPILYAFLSDNFK 223
Cdd:cd14989 214 LPENVF--ISIQLLQGTQEPSESydesfrhnhplTGHIVNLAAFSNSCLNPLIYSFLGETFR 273
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
10-226 3.21e-14

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 71.09  E-value: 3.21e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILPIMiyaglrs 88
Cdd:cd15959  65 HWPLGTTVCELWTSVDVLCVTASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAIsFLPIM------- 137
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGR-------SSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIII------------KVKSSGIRVGSSK 149
Cdd:cd15959 138 NQWWRdgadeeaQRCYDNPRCCDFVTNMPYAIVSSTVSFYVPLLVMIFVYVRVFVvatrqvrlirkdKVRFPPEESPPAE 217
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 150 RKKSEK------------KVTRMVSIVVAVFIFCWLPFYIFNVSSV-SMAISPTPAlkgmFDFVVVLTYANSCANPILYA 216
Cdd:cd15959 218 SRPACGrrpsrllaikehKALKTLGIIMGTFTLCWLPFFVANIIKVfCRSLVPDPA----FLFLNWLGYANSAFNPIIYC 293
                       250
                ....*....|
gi 12652991 217 fLSDNFKKSF 226
Cdd:cd15959 294 -RSPDFRSAF 302
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
16-222 3.70e-14

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 70.98  E-value: 3.70e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  16 AICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSakWRRP-RTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGrs 94
Cdd:cd15386  71 LLCRAVKYLQVLSMFASTYMLIMMTVDRYIAVCHPLRT--LQQPsRQAYLMIGATWLLSCILSLPQVFIFSLREVDQG-- 146
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  95 SCTIN-WPGESGAW-YTGFIIYTFILGFLVPLTIICLCYLFII------IKVKSSGIRV--------GSSKRKKSEKKVT 158
Cdd:cd15386 147 SGVLDcWADFGFPWgAKAYITWTTLSIFVLPVAILIVCYSLICyeicknLKGKTQTSRSegggwrtqGMPSRVSSVRTIS 226
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12652991 159 R-------MVSIVVAVFIFCWLPFYIFNVSSVSMAISPTP-ALKGMFDFVVVLTYANSCANPILYAFLSDNF 222
Cdd:cd15386 227 RakirtvkMTFVIVLAYIACWAPFFSVQMWSVWDENAPDEdSSDFAFTITMLLASLSSCCNPWIYMFFSGHL 298
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
11-226 3.81e-14

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 70.58  E-value: 3.81e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAglRSNQ 90
Cdd:cd15364  66 WPWGSLACKITGYIFFCNIYISILLLCCISIDRFVAVVYALESRGRRRQRIAAFISFLIFIVVGLVHSPVFIMR--EGQT 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTinWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirvgSSKRKKSEKKVTRMVSIVVAVFIF 170
Cdd:cd15364 144 EGSHTCF--ETLQMDTQVAGFYYARFCIGFAIPLAILIFTNYRIFRSIQTS-----TSLTPHQKAKVKYLAIAVIVIFLI 216
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 171 CWLPFY-IFNVSSVSMAISPtpalKGMFDF----------VVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15364 217 CFAPYHlVLLVRAIAFSLYP----NGMCGFeeriytpsviFLCLSTVNSVADPIIYVLVSENVRQDI 279
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
1-215 4.09e-14

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 70.09  E-value: 4.09e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHpiksakwRR----PRTAKMITMAVWGVSLLV 76
Cdd:cd15213  56 FAAVTIITGRWIFGDIFCRISAMLYWFFVLEGVAILLIISVDRYLIIVQ-------RQdklnPHRAKILIAVSWVLSFCV 128
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  77 ILPIMIYAGLRSNQWGRSSCTINWPGESGawYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVgsskrkksekk 156
Cdd:cd15213 129 SFPPLVGWGKYEFPPRAPQCVLGYTESPA--DRIYVVLLLVAVFFIPFLIMLYSYFCILNTVRSFKTRA----------- 195
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 157 vTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMfdFVVVLTYANSCANPILY 215
Cdd:cd15213 196 -FTTILILFIGFSVCWLPYTVYSLLSVFSRYSSSFYVIST--CLLWLSYLKSAFNPVIY 251
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
2-226 4.28e-14

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 70.24  E-value: 4.28e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   2 LAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIK-SAKWRRPRTAKMITMAvWGVSLLvILPI 80
Cdd:cd15301  57 FTVYTALGYWPLGYEVCDTWLAIDYLASNASVLNLLIISFDRYFSVTRPLTyRARRTTKKAAVMIASA-WIISLL-LWPP 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAglrsnqwgrssctinWP-------GESGAWYTGFIIY-------TFILGFLVPLTIICLCYLFIIIKVKSSGIRvg 146
Cdd:cd15301 135 WIYS---------------WPyiegkrtVPAGTCYIQFLETnpyvtfgTALAAFYVPVTIMCILYWRIWRETKKRQKK-- 197
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 147 sskrkkSEKKVTRMVSIVVAVFIFCWLPfyiFNVSSVSMAISPTPAL--KGMFDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15301 198 ------QESKAAKTLSAILLAFIVTWTP---YNVLVLIKAFFPCSDTipTELWDFSYYLCYINSTINPLCYALCNAAFRR 268

                ..
gi 12652991 225 SF 226
Cdd:cd15301 269 TY 270
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
1-224 5.91e-14

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 70.25  E-value: 5.91e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPiksaKWRRPRTAKMI--TMAVWGVSLLVIL 78
Cdd:cd15396  56 FTAVYTLMDHWIFGETMCKLTSFVQSVSVSVSIFSLVLIAIERYQLIVNP----RGWKPSASHAYwgIVLIWLFSLMISI 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  79 PIMIYAGLRSNQWGRSS-----------CTINWPGEsgawyTGFIIYT---FILGFLVPLTIICLCYL--FIIIKVKSSG 142
Cdd:cd15396 132 PFLIFHQLTDEPFRNLSshsdfykdkvvCIEAWPSE-----TERLIFTtslLVFQYFVPLGFIFICYLkiFVCLKKRNSK 206
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 143 I---RVGSSKRKKSEKKVTRMVSIVVAvFIFCWLPFYIFNV-----SSVSMAISPTPAlkgmFDFVVVLTYANSCANPIL 214
Cdd:cd15396 207 IdrmRENESRLSENKRINTMLISIVVT-FAACWLPLNIFNVvfdwnHEVLMSCHHNLV----FTLCHLVAMVSTCINPIF 281
                       250
                ....*....|
gi 12652991 215 YAFLSDNFKK 224
Cdd:cd15396 282 YGFLNKNFQK 291
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
6-226 6.19e-14

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 69.88  E-value: 6.19e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   6 VALVH--WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIY 83
Cdd:cd15400  59 VAIFHngWALGEMHCKVSGFVMGLSVIGSIFNITGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIWALTVVAIVPNFFV 138
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  84 AGLRSNQwGRSSCTINWPGESgaWYTgfiIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTR---M 160
Cdd:cd15400 139 GSLEYDP-RIYSCTFVQTASS--SYT---IAVVVIHFIVPITVVSFCYLRIWVLVIQVRRKVKSESKPRLKPSDFRnflT 212
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 161 VSIVVAVFIFCWLPfyiFNVSSVSMAISPT---PAL-KGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15400 213 MFVVFVIFAICWAP---LNLIGLAVAINPQemaPKVpEWLFVVSYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
11-223 8.26e-14

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 69.91  E-value: 8.26e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGL---- 86
Cdd:cd15131  66 WNFGDLLCKLFQFVSESCTYSTILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPIFVLVGVehen 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  87 RSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFlvpLTIICLCYLFIII-----KVKSSGIRVGSSKRKKSEKKVTRMV 161
Cdd:cd15131 146 GTNPIDTNECKATEYAVRSGLLTIMVWVSSVFFF---LPVFCLTVLYSLIgrklwRRRRENIGPNASHRDKNNRQTVKML 222
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 162 SIVVAVFIFCWLPFYI--FNVSSVSMAISPTPALKGMFDFVV--VLTYANSCANPILYAFLSDNFK 223
Cdd:cd15131 223 AVVVFAFVLCWLPFHVgrYLFSKSFEAGSLEIALISQYCNLVsfVLFYLSAAINPILYNIMSKKYR 288
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
10-226 8.94e-14

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 69.64  E-value: 8.94e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd15048  65 KWPFGKVFCKAWLVVDYTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGPAIIGWDLWTG 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWgrssctINWPGESGAWYTGFIIYTFI---LGFLVPLTII----CLCYLFIIIKVKSSGIRVGSSKRKKSEKK------ 156
Cdd:cd15048 145 YS------IVPTGDCEVEFFDHFYFTFItsvLEFFIPFISVsffnLLIYLNIRKRSRRRPLRSVPILPASQNPSrarsqr 218
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 157 ----------VTRMVSIVVAVFIFCWLPFYIFnvSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15048 219 eqvklrrdrkAAKSLAILVLVFLICWAPYTIL--TIIRSFCSGSCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
1-226 1.07e-13

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 69.79  E-value: 1.07e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILP 79
Cdd:cd15058  56 LGATIVVTGKWQLGNFWCELWTSVDVLCVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVsFVP 135
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  80 IMiyaglrsNQWGRSSCTINWPGESGAWYTGFI------IYTFILGFLVPLTIICLCYL--FIIIKVKSSGIR------- 144
Cdd:cd15058 136 IM-------NQWWRANDPEANDCYQDPTCCDFRtnmayaIASSVVSFYIPLLIMIFVYArvFLIATRQLQLIDkrrlrfq 208
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 145 -VGSSKRKKSEKKVTRM------------------VSIVVAVFIFCWLPFYIFNVSSVSmaispTPALKGMFDFVVV--L 203
Cdd:cd15058 209 sECPAPQTTSPEGKRSSgrrpsrltvvkehkalktLGIIMGTFTLCWLPFFIANIINVF-----NRNLPPGEVFLLLnwL 283
                       250       260
                ....*....|....*....|...
gi 12652991 204 TYANSCANPILYAFlSDNFKKSF 226
Cdd:cd15058 284 GYINSGLNPIIYCR-SPEFRTAF 305
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
10-226 1.38e-13

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 68.74  E-value: 1.38e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAglRSN 89
Cdd:cd15324  65 YWYFGSTWCAFYLALDVLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMT--KHD 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWgrsSCTINwpgeSGAWYtgfIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRvgsskrkksekkVTRMVSIVVAVFI 169
Cdd:cd15324 143 EW---ECLLN----DETWY---ILSSCTVSFFAPGLIMILVYCKIYRVAKMREKR------------FTFVLAVVMGVFV 200
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 170 FCWLPFYiFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15324 201 LCWFPFF-FTYSLHAVCRKRCGIPDALFNLFFWIGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
11-226 1.83e-13

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 68.77  E-value: 1.83e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILPIMIYAGlRSN 89
Cdd:cd15958  66 WLYGSFFCELWTSVDVLCVTASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVsFLPIMMHWW-RDE 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVK---------------------SSGIRVGSS 148
Cdd:cd15958 145 DDQALKCYEDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKkqikkidkcegrfhntltglgRKCKRRPSR 224
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 149 KRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMA-ISPtpalKGMFDFVVVLTYANSCANPILYAfLSDNFKKSF 226
Cdd:cd15958 225 ILALREQKALKTLGIIMGVFTLCWLPFFLVNVVNVFNReLVP----DWLFVFFNWLGYANSAFNPIIYC-RSPDFRKAF 298
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
11-226 2.22e-13

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 68.39  E-value: 2.22e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd15402  66 WNLGYLHCQISGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPNLFVGSLQYDP 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 wGRSSCTINWPGESgawytGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTR---MVSIVVAV 167
Cdd:cd15402 146 -RIYSCTFAQSVSS-----AYTIAVVFFHFILPIIIVTFCYLRIWILVIQVRRRVKPDNKPKLKPHDFRnfvTMFVVFVL 219
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 168 FIFCWLPfyiFNVSSVSMAISPTPALKGMFDFVVV----LTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15402 220 FAVCWAP---LNFIGLAVAVDPETIVPRIPEWLFVasyyMAYFNSCLNAIIYGLLNQNFRREY 279
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
1-223 2.87e-13

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 68.23  E-value: 2.87e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQvALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVvhpikSAKWRRPRTAKM---ITMAVWGVSLLVI 77
Cdd:cd15176  55 FWAAD-AVNGWVLGTAMCKITSALYTMNFSCGMQFLACISVDRYVAI-----TKATSRQFTGKHcwiVCLCVWLLAILLS 128
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  78 LPIMIYAGLRSNQwGRSSCTINWPGESGAWYTGFI-IYTFILGFLVPLTIICLCYLFIIIKV-KSSGIRvgsskrkksEK 155
Cdd:cd15176 129 IPDLVFSTVRENS-DRYRCLPVFPPSLVTSAKATIqILEVLLGFVLPFLVMVFCYSRVARALsRTPNVK---------KS 198
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12652991 156 KVTRMVSIVVAVFIFCWLPFYIF-------NVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFK 223
Cdd:cd15176 199 RALKVLLAVVGVFIVTQLPYNVVkfyraidVIYLLITDCSMSKTLDIAIQVTESIALFHSCLNPVLYVFMGASFK 273
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
2-226 4.11e-13

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 67.28  E-value: 4.11e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   2 LAMQVALVH------WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLL 75
Cdd:cd15328  52 LVMPLSLVHelsgrrWQLGRSLCQVWISFDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWALSAV 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  76 VILPIMIYAGLRSNQWGRSSCTINWPgesgawyTGFIIYTFILGFLVPLTIICLCYlFIIIKVKSSGIRVGSskrkksek 155
Cdd:cd15328 132 ISLAPLLFGWGETYSEDSEECQVSQE-------PSYTVFSTFGAFYLPLCVVLFVY-WKIYKAAQKEKRAAL-------- 195
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 156 kvtrMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFdfvVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15328 196 ----MVGILIGVFVLCWIPFFLTELISPLCSCDIPPIWKSIF---LWLGYSNSFFNPLIYTAFNKNYNNAF 259
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
10-226 4.54e-13

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 67.30  E-value: 4.54e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAglrsn 89
Cdd:cd17790  65 HWALGTVACDLWLALDYVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILFW----- 139
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTInwpgESGAWYTGFI---IYTF---ILGFLVPLTIICLCYLFI---IIKVKSSGirvgsskrkksekkvtRM 160
Cdd:cd17790 140 QYLVGERTV----LAGQCYIQFLsqpIITFgtaIAAFYLPVTIMIILYWRIyreTIKEKKAA----------------RT 199
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 161 VSIVVAVFIFCWLPFYIFNVSSvsmAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd17790 200 LSAILLAFILTWTPYNIMVLVS---TFCKDCVPKTLWELGYWLCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
32-226 5.16e-13

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 67.11  E-value: 5.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITmAVWGVSLLV-ILPIMIYaglrsNQWGR-SSCTINWPgesgaWYT 109
Cdd:cd15102  86 SVFSLLAIAIERHLTMAKMKPYGASKTSRVLLLIG-ACWLISLLLgGLPILGW-----NCLGAlDACSTVLP-----LYS 154
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 110 GFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISP 189
Cdd:cd15102 155 KHYVLFCVTIFAGILAAIVALYARIYCLVRASGRKATRASASPRSLALLKTVLIVLLVFIACWGPLFILLLLDVACPVKT 234
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 12652991 190 TPALKGMfDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15102 235 CPILYKA-DWFLALAVLNSALNPIIYTLRSRELRRAV 270
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
10-226 5.50e-13

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 67.67  E-value: 5.50e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGkAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILPIMIyaglrs 88
Cdd:cd15319  66 YWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLIsFIPVQL------ 138
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 nQWGRSSCTiNWPGESGAWYTG-------------FIIYTFILGFLVPLTIICLCYLFII------IKVKSSGIRVG--- 146
Cdd:cd15319 139 -NWHKDSGD-DWVGLHNSSISRqveencdsslnrtYAISSSLISFYIPVAIMIVTYTRIYriaqiqIRRISSLERAAeha 216
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 147 ---------------SSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGM-------FDFVVVLT 204
Cdd:cd15319 217 qscrsnridchhhtsLRTSIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCDRPPADPDAGLpcvsettFDVFVWFG 296
                       250       260
                ....*....|....*....|..
gi 12652991 205 YANSCANPILYAFLSDnFKKSF 226
Cdd:cd15319 297 WANSSLNPIIYAFNAD-FRKVF 317
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
10-226 6.64e-13

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 66.75  E-value: 6.64e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILPIMIyaGLRS 88
Cdd:cd15054  65 RWVLARDFCPIWYAFDVMCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALAsFLPIEL--GWHE 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRSSCTINWPGESGAWY----TGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirvgsskrkkseKKVTRMVSIV 164
Cdd:cd15054 143 LGHERTLPNLTSGTVEGQCRllvsLPYALVASCLTFFLPSGAICFTYCRILLAARKA-------------LKASLTLGIL 209
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 165 VAVFIFCWLPFYIFNVS-SVSMAISPtpalkGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15054 210 LGMFFVTWLPFFVANVVqAVCDCVSP-----GLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 267
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
11-226 8.26e-13

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 66.99  E-value: 8.26e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIksakwrrpRTAKMITMAVWGVSLLV--ILPIMIYAGL-- 86
Cdd:cd15312  66 WYFGDLFCKIHSSLDMMLSTTSIFHLCFIAVDRYYAVCDPL--------HYRTKITTPVIKVFLVIswSVPCLFAFGVvf 137
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  87 -RSNQWG----------RSSCTINWPGESGAwytgfiiYTFILGFLVPLTIICLCYLFIII------KVKSSGIRVGSSK 149
Cdd:cd15312 138 sEVNLEGiedyvalvscTGSCVLIFNKLWGV-------IASLIAFFIPGTVMIGIYIKIFFvarkhaKVINNRPSVTKGD 210
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 150 RKKSEKK-----VTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISpTPAlkGMFDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15312 211 SKNKLSKkkerkAAKTLSIVMGVFLLCWLPFFVATLIDPFLNFS-TPV--DLFDALVWLGYFNSTCNPLIYGFFYPWFQK 287

                ..
gi 12652991 225 SF 226
Cdd:cd15312 288 AF 289
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
11-226 8.85e-13

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 66.89  E-value: 8.85e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd15130  71 WAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNES 150
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSS-----CTinwPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgIRVGsskrkksekkvTRMVSIVV 165
Cdd:cd15130 151 DDGTHpgglvCT---PIVDTATLKVVIQVNTFMSFLFPMLVTSILNTVIANKLVQA-LRRG-----------VLVLRAVV 215
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12652991 166 AVFIFCWLPFYIFNVssVSMAISPTPALKGMFDF-------VVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15130 216 IAFVVCWLPYHVRRL--MFCYISDEQWTTFLFDFyhyfymlTNALFYVSSAINPILYNLVSANFRQVF 281
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
11-226 8.89e-13

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 66.77  E-value: 8.89e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAkwRRPRTAKMITMAVWGVSLLVILPIMIYAGL---- 86
Cdd:cd15981  66 WPFDNAMCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPFRQK--LTLRKAIVTIVIIWVLALIIMCPSAVTLTVtree 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  87 -------RSNQWGRSSCTINWPGESGAWYTGFIIYTFIlgFLVPLTIICLCYLFIIIKV-KSSGIRVGSSKRKKSEKKVT 158
Cdd:cd15981 144 hhfmvddYNNSYPLYSCWEAWPDTEMRKIYTTVLFSHI--YLAPLTLIVIMYARIAFKLfKSSAPIRGSQGEEEEGRRVS 221
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 159 R-------MVSIVVAVFIFCWLPFYIFNVSSVSMAISpTPALKGM----FDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15981 222 KrkikvinMLIIVALFFTLSWLPLWTLMLLTDYGHLS-EDQLNLVtvyvFPFAHWLAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
11-226 1.46e-12

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 65.92  E-value: 1.46e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILpIMIYAGLRSNQ 90
Cdd:cd15302  67 WPLGWVLCDLWLSVDYTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWIIPALLFF-ISIFGWQYFTG 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCtinwPGESGAWYTGFIIytFILGFLVPLTIICLCYLFIIIKvkssgirvGSSKRKKSEKKVTRMVSIVVAVFIF 170
Cdd:cd15302 146 QGRSLP----EGECYVQFMTDPY--FNMGMYIGYYWTTLIVMLILYA--------GIYRAANRARKALRTITFILGAFVI 211
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 171 CWLPFYIFnVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15302 212 CWTPYHIL-ATIYGFCEAPPCVNETLYTISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
17-226 1.61e-12

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 66.00  E-value: 1.61e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  17 ICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAvWGVSLLVILPIMIYAGLRSNQWGrSSC 96
Cdd:cd15385  72 LCRIVKHLQVLGMFASTYMLVMMTADRYIAICHPLKTLQQPTKRSYLMIGSA-WALSFILSTPQYFIFSLSEIENG-SGV 149
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  97 TINWPGESGAWYT-GFIIYTFILGFLVPLTIICLCYLFII------IKVKS-SGIRVGSSKRKKSEKKVT---------- 158
Cdd:cd15385 150 YDCWANFIVPWGIkAYITWITISIFVVPVIILLTCYGFICyniwrnIKCKTrRGLSDNALKNILLAVCVSsvktisraki 229
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12652991 159 ---RMVSIVVAVFIFCWLPFYIFNVSSVSMAISP-TPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15385 230 rtvKMTFVIVLAYIVCWAPFFTIQMWSVWDQNFPwDESENTAVTITALLASLNSCCNPWIYMFFSGHLLQDF 301
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
11-226 1.69e-12

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 65.93  E-value: 1.69e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILpIMIYAGLRSNQ 90
Cdd:cd15317  66 WYFGDLFCKFHTGLDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTF-GLIYTGANDEG 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCY--LFII-------IKVKSSGIRVGSSKRKKSEKKVTR-- 159
Cdd:cd15317 145 LEEYSSEISCVGGCQLLFNKIWVLLDFLTFFIPCLIMIGLYakIFLVarrqarkIQNMEDKFRSSEENSSKASASRERka 224
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 160 --MVSIVVAVFIFCWLPFYIFNVSSVSMAISpTPALkgMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15317 225 akTLAIVMGIFLFCWLPYFIDTIVDEYSNFI-TPAI--VFDAVIWLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
31-226 1.77e-12

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 65.91  E-value: 1.77e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  31 TSIFCLTVMSIDRYLAVVHPIKSAKWRRprTAKMITMAVWGVSLLVILPIMIYAGLRSNQWG---RSSCTINWPGESGAW 107
Cdd:cd15000  85 ASVLALCAVSYDRLTAIVLPSEARLTKR--GAKIVIVITWIVGLLLALPLAIYRSYRERQWKnflETYCAENTQVLPIYW 162
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 108 YtgfiiytFILGFLV--PLTIICLCYLFIIIKVKSSGIRV---GSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIF---- 178
Cdd:cd15000 163 H-------VIITVLVwlPLGIMLICYSAIFWKLDKYERRVlrrEHPSVVRYKKKAAKTLFIVLITFVVCRIPFTALifyr 235
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 12652991 179 --NVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15000 236 ykLVPNDNTQNSVSGSFHILWFASKYLMFLNAAVNPLIYGFTNENFRKAF 285
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
11-226 1.84e-12

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 66.18  E-value: 1.84e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGkAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILPIMI------- 82
Cdd:cd15320  68 WPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLIsFIPVQLnwhkakp 146
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  83 YAGLRSNQWGRSSCTINWPGESGAWYTgfiIYTFILGFLVPLTIICLCYLFIIiKVKSSGIR------------------ 144
Cdd:cd15320 147 TSFLDLNASLRDLTMDNCDSSLNRTYA---ISSSLISFYIPVAIMIVTYTRIY-RIAQKQIRrisaleraavhakncqns 222
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 145 -------------VGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNV--------SSVSMAISPTpalkgMFDFVVVL 203
Cdd:cd15320 223 tgnrgsgdcqqpeSSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCmvpfckptSTEPFCISST-----TFDVFVWF 297
                       250       260
                ....*....|....*....|...
gi 12652991 204 TYANSCANPILYAFLSDnFKKSF 226
Cdd:cd15320 298 GWANSSLNPIIYAFNAD-FRKAF 319
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
11-226 1.95e-12

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 65.70  E-value: 1.95e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPiMIYAGLRSNQ 90
Cdd:cd15401  66 WTLGNIHCQISGFLMGLSVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTLAAIVP-NFFVGSLQYD 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTInwpgeSGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTR---MVSIVVAV 167
Cdd:cd15401 145 PRIYSCTF-----AQTVSSSYTITVVVVHFIVPLSIVTFCYLRIWVLVIQVKHRVRQDSKQKLKANDIRnflTMFVVFVL 219
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 168 FIFCWLPfyiFNVSSVSMAISPTPALKGMFDFVVVLT----YANSCANPILYAFLSDNFKKSF 226
Cdd:cd15401 220 FAVCWGP---LNFIGLAVAINPLKVAPKIPEWLFVLSyfmaYFNSCLNAVIYGVLNQNFRKEY 279
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
2-226 2.11e-12

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 66.02  E-value: 2.11e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   2 LAMQVAL-----VH--WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAK-WRRPRTAKMITmAVWGVS 73
Cdd:cd15355  55 LAMPVELynfiwVHhpWAFGDAACRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKSlMSRSRTKKFIS-AIWLAS 133
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  74 LLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLC------YLFIIIKVKSSGIRVGS 147
Cdd:cd15355 134 ALLAIPMLFTMGEQNRSGTHPGGLICTPIVDTSTLKVVIQVNAFLSFLFPMLVISVLntlianQLTVMVNQAEQENQVCT 213
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 148 SKRKKSEKKVT-------------RMVSIVVAVFIFCWLPFYIFNVssVSMAISPTPALKGMFDF-------VVVLTYAN 207
Cdd:cd15355 214 IGGQRTVLSVSmepgrvqslrhgvLVLRAVVIAFVVCWLPYHVRRL--MFCYVSDEQWTTFLYDFyhyfymlTNVLFYVS 291
                       250
                ....*....|....*....
gi 12652991 208 SCANPILYAFLSDNFKKSF 226
Cdd:cd15355 292 SAINPILYNLVSANFRQIF 310
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
32-217 2.49e-12

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 65.39  E-value: 2.49e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILPIMIYAGLRSNQwgrSSCTINWPGESgawyTG 110
Cdd:cd14972  84 SAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLaLLPVLGWNCVLCDQ---ESCSPLGPGLP----KS 156
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 111 FIIYTFILgFLVPLTIICLCYLFIIIKVKS--SGIRVGSSKRKKSEKKVTR----MVSIVVAVFIFCWLPFYIFNVSSVS 184
Cdd:cd14972 157 YLVLILVF-FFIALVIIVFLYVRIFWCLWRhaNAIAARQEAAVPAQPSTSRklakTVVIVLGVFLVCWLPLLILLVLDVL 235
                       170       180       190
                ....*....|....*....|....*....|...
gi 12652991 185 MaiSPTPALKGMFDFVVVLTYANSCANPILYAF 217
Cdd:cd14972 236 C--PSVCDIQAVFYYFLVLALLNSAINPIIYAF 266
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
13-231 3.67e-12

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 65.27  E-value: 3.67e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  13 FGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRpRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWG 92
Cdd:cd15084  78 FGKTMCEFEGFMVSLTGIVGLWSLAILAFERYLVICKPMGDFRFQQ-RHAVSGCAFTWGWSLLWTSPPLFGWSSYVPEGL 156
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  93 RSSCTINWpgesgawYTG------FIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSS-KRKKSEKKVTRMVSIVV 165
Cdd:cd15084 157 RTSCGPNW-------YTGgtnnnsYILALFVTCFALPLSTIIFSYSNLLLTLRAVAAQQKESeTTQRAEKEVTRMVIAMV 229
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 166 AVFIFCWLPFYIFN-VSSVSMAISPTPALKGMFDFvvvLTYANSCANPILYAFLSDNFKKSFQNVLC 231
Cdd:cd15084 230 MAFLICWLPYATFAmVVATNKDVVIQPTLASLPSY---FSKTATVYNPIIYVFMNKQFRSCLLELLC 293
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
17-219 4.66e-12

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 64.84  E-value: 4.66e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  17 ICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAkwrRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSC 96
Cdd:cd15387  72 LCRLVKYLQVVGMFASTYMLLLMSIDRCLAICQPLRSL---HRRSDRVYVLFSWLLSLVFSIPQVHIFSLREVGNGVYDC 148
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  97 tinWPGESGAW-YTGFIIYTFILGFLVPLTIICLCYLFIIIKV------------------KSSG----IRVGSSKRKKS 153
Cdd:cd15387 149 ---WADFIQPWgPKAYITWITLSVYIIPVLILSVCYGLISFKIwqnvklktrretktplssAASGgaalARVSSVKLISK 225
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 154 EKKVT-RMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALkgMFDFVVVLTYANSCANPILYAFLS 219
Cdd:cd15387 226 AKIRTvKMTFVIVLAYIVCWTPFFFVQMWSVWDPNAPKEAS--PFIIAMLLASLNSCCNPWIYMFFT 290
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
11-225 4.69e-12

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 64.50  E-value: 4.69e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSlLVILPIMIYAGLRSNQ 90
Cdd:cd15318  66 WYFGDSFCRLHTCLDTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVP-TVYTSVFLYTKAVEEG 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCY--LFIIIKVKSSGIRVGSSKRKKSEKK---VTRMVSIVV 165
Cdd:cd15318 145 LAELLTSVPCVGSCQLLYNKLWGWLNFPVFFIPCLIMIGLYvkIFIVAKRQARAIASLLSDTNGASKRerkAAKTLGIAV 224
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 166 AVFIFCWLPFYIFNVSSVSMAISPTPALkgmFDFVVVLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15318 225 GVYLLCWLPFTIDTMVDSLLNFITPPLL---FDIIIWFAYFNSACNPLIYVFSYPWFRKA 281
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
11-216 7.24e-12

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 64.13  E-value: 7.24e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRtAKMITMAVWGVSLL-VILPIMIyaglrsn 89
Cdd:cd15079  65 WALGPLGCQIYAFLGSLSGIGSIWTNAAIAYDRYNVIVKPLNGNPLTRGK-ALLLILFIWLYALPwALLPLLF------- 136
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGR-------SSCTI-----NWPGESgawytgFIIYTFILGFLVPLTIICLCYLFIIIKVKS---------------SG 142
Cdd:cd15079 137 GWGRyvpegflTSCSFdyltrDWNTRS------FVATIFVFAYVIPLIIIIYCYSFIVKAVFAhekalreqakkmnvvSL 210
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 143 IRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVS---MAISPtpalkGMFDFVVVLTYANSCANPILYA 216
Cdd:cd15079 211 RSNADANKQSAEIRIAKVALTNVFLWFIAWTPYAVVALIGAFgnqSLLTP-----LVSMIPALFAKTAACYNPIVYA 282
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
8-225 8.40e-12

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 64.07  E-value: 8.40e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   8 LVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLR 87
Cdd:cd15150  62 LGSWPLRGFVCQVTSVIFYFTMYISILFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSTVIWASMFALSLPNMILTNRQ 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  88 SNQWGRSSCTInWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVgSSKRKKSEKKVTRMVSIVVAV 167
Cdd:cd15150 142 PTPKNVKKCSL-LKSEFGLVWHEIVNYICQVIFWVNFLIVIVCYTLITKELYKSYKRT-RGVGKVSRKKVNVKVFIIIAV 219
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12652991 168 FIFCWLPFYIFNVS---SVSMAISPTPALKGMF---DFVVVLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15150 220 FFICFVPFHFARIPytlSQTRDVFDCTAKNTLFyvkESTLWLTSLNACLDPFIYFFLCKSFRNS 283
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
9-177 1.02e-11

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 63.63  E-value: 1.02e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   9 VHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRS 88
Cdd:cd15923  62 RESAGLQKLCNFVLSLYYINMYVSIFTITAISVDRYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISIPYFLLDSSNE 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRSSCTINWPGEsgawytgFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGsskRKKSEKKVTRMVSIVVAVF 168
Cdd:cd15923 142 KTMCFQRTKQTESLK-------VFLLLEIFGFLLPLIIMTFCSARVIHTLQKRLDDVG---SRSETKQCIRVIMANLIVF 211

                ....*....
gi 12652991 169 IFCWLPFYI 177
Cdd:cd15923 212 IVCFLPVHV 220
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
11-226 1.13e-11

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 63.77  E-value: 1.13e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGL---- 86
Cdd:cd15124  66 WLFGRVGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPEAVFSDLhpfy 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  87 -RSNQWGRSSCTiNWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIR------VGSSKRKKSEKKVTR 159
Cdd:cd15124 146 dKSTNKTFVSCA-PYPHSNELHPKIHSMASFLIFYVIPLSIISVYYYFIAKNLIRSAYNlpvegnVHVRRQIESRKRLAK 224
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12652991 160 MVSIVVAVFIFCWLPFYI------FNVSSVSMAisptpalkgMFDFVV-----VLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15124 225 TVLVFVGLFAFCWLPNHIiylyrsYHYSEVDTS---------MLHFVSsicarILAFTNSCVNPFALYLLSKSFRKQF 293
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
13-219 1.17e-11

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 63.22  E-value: 1.17e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  13 FGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWG 92
Cdd:cd14964  66 RPQALCYLIYLLWYGANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNT 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  93 RSSCTINWPGESGAWytgfiIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIF-- 170
Cdd:cd14964 146 LTGSCYLICTTIYLT-----WGFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNTDKNLKATKSLLILVITFll 220
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 12652991 171 CWLPFYIFNVSSVSMAISptPALKGMFDFVVVLTYANSCANPILYAFLS 219
Cdd:cd14964 221 CWLPFSIVFILHALVAAG--QGLNLLSILANLLAVLASTLNPFIYCLGN 267
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
11-177 1.24e-11

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 63.51  E-value: 1.24e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMiyaGLRSNQ 90
Cdd:cd15165  64 WPLGRTLCSFLESLYFVNMYGSILIIVCISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIPIY---SFHDKP 140
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTINWPGESgaWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirvgsSKRKKSEKKVTRMVSIVVA---V 167
Cdd:cd15165 141 TNNTRCFHGFSNKT--WSKKVIVVVEEFGFLIPMAVMVFCSVQIIRTLLDM------RRPEQPKVKQNKSVKIVLSnlvV 212
                       170
                ....*....|
gi 12652991 168 FIFCWLPFYI 177
Cdd:cd15165 213 FLVCFTPYHL 222
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
11-231 1.43e-11

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 62.92  E-value: 1.43e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIkSAKWRRPRTAKMIT--MAVWGVSLLVILPIMIYAglRS 88
Cdd:cd15295  66 WDFGRGLCVFWLVIDYLLCTASVYNIVLISYDRYQSVSNAV-SYRNQQTATLRIVTqmVAVWVLAFLVHGPAILVS--DS 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRSSCTinwPGESGAWYtgFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirvgsskrkKSEKKVTRMVSIVVAVF 168
Cdd:cd15295 143 WKTEDGECE---PEFFSNWY--ILAITSVLEFLVPVILVAYFNTQIYWSLWKR----------LRDRKLAKSLAIILGTF 207
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 169 IFCWLPFYIFNVSSVSMAISPTPALkgmFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLC 231
Cdd:cd15295 208 AICWAPYSLFTIIRAACEKHRGSPW---YNFAFWLQWFNSFINPFLYPLCHKRFRKAFLKIFC 267
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
11-223 1.61e-11

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 63.28  E-value: 1.61e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGL---- 86
Cdd:cd15132  66 WIFGEFLCRLYHYISEGCTYATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAGPFLFLVGVeqdn 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  87 --RSNQWGRSSCTINWPGESGAwyTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRV---GSSKRKKSEKKVTRMV 161
Cdd:cd15132 146 niHPDDFSRECKHTPYAVSSGL--LGIMIWVTTTYFFLPMLCLSFLYGFIGRKLWKSKNDLrgpNAAARERSHRQTVRIL 223
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 162 SIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFV-VVLTYANSCANPILYAFLSDNFK 223
Cdd:cd15132 224 AVVVLAFIICWLPFHIGRILFANTEDYRTMMFSQYFNIVaMQLFYLSASINPILYNLISRKYR 286
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
11-226 1.72e-11

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 62.78  E-value: 1.72e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIK-SAKWRRPRTAKMITMaVWGVSLLV-ILPIMIyaglrs 88
Cdd:cd15066  65 WMFGYFMCDVWNSLDVYFSTASILHLCCISVDRYYAIVQPLEyPSKMTKRRVAIMLAN-VWISPALIsFLPIFL------ 137
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 nqwgrssctinwpgesgAWYTG---------------FI---IYTFI---LGFLVPLTIICLCYLFIIIKVKSSgirvgs 147
Cdd:cd15066 138 -----------------GWYTTeehlqyrkthpdqceFVvnkIYALIsssVSFWIPCIVMIFTYYRIYLEAKRE------ 194
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 148 skrkkseKKVTRMVSIVVAVFIFCWLPFYIFNVS-SVSMAISPTPALKGMFDFVVvlTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15066 195 -------HKAAKTLGIIMGAFILCWLPFFLWYVTtTLCGDACPYPPILVSILFWI--GYFNSTLNPLIYAYFNRDFREAF 265
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
11-219 1.97e-11

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 62.89  E-value: 1.97e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIY-AGLRSN 89
Cdd:cd15371  65 WVFGETMCRIITITFYGNMYCSILLLTCISINRYLAIVHPFIYRSLPKKTYAVLICALVWTIVFLYMLPFFILkQTYYLK 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINWPGESGAWYTGFIIYTF--ILGFLVPLTIICLCYLFIIIKVKSSGIRvgsskrkksEKKVTRMVSIVVAV 167
Cdd:cd15371 145 ELNITTCHDVLPECEQNSNFQFYYFISmaVFGFLIPLVITIFCYISIIRTLNAYEHK---------WFWYVKITALVLII 215
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 12652991 168 FIFCWLPF-YIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLS 219
Cdd:cd15371 216 FTICFAPSnVILIIHHFNYYYFNNDNLYSIYLIALCLGSLNSCLDPFLYFLMS 268
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
2-225 2.76e-11

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 62.51  E-value: 2.76e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   2 LAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIM 81
Cdd:cd15920  53 LPFRVAYQNTAGPLSFCKIVGAFFYLNMYASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSAASGGVWLLLLACMIPFL 132
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  82 IYAGlrsnqwGRSSCT-INWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRM 160
Cdd:cd15920 133 FESR------NEGPCDnKCFHFRSKGLTAGGINLTAVVIFYILSLLFLYFYAKISHKLYKVSLGNAQQQIKKASKRAIIK 206
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 161 VSIVVAVFIFCWLPFYIFNVSSVSM---AISPTPALKG---MFDFVVVLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15920 207 TFIVLAIFIVCFVPYHIVRVPYVLAqidVISSLPWKQTlhiANELVLCLSALNSCLDPIIYFFLSSSFRRA 277
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
11-223 3.03e-11

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 62.43  E-value: 3.03e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIM--IYAGLRS 88
Cdd:cd15378  65 WLFGDFLCKSNRYLLHANLYSSILFLTFISIDRYLLIKYPFREHILQKKRSAVAISLAIWVLVTLELLPILtfIGPNLKD 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQwgrSSCtINWPGESGAwyTGFIIYTFIL---GFLVPLTIICLCYLFIIIKVKSsgiRVGSSKRKKSEKKVTRMVSIVV 165
Cdd:cd15378 145 NV---TKC-KDYASSGDA--TNSLIYSLFLtvtGFLIPLCVMCFFYYKIALFLKN---RNRQLANATSFEKPLTLVILAV 215
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12652991 166 AVFIFCWLPFYIF-NVSSVSMAISPTPA------LKGMFDFVVVLTYANSCANPILYAFLSDNFK 223
Cdd:cd15378 216 VIFSVLFTPYHVMrNVRIASRLDSIGVSectliiIKSLYIVTRPIAFLNSVINPVFYFLMGDHFR 280
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
31-226 3.29e-11

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 62.26  E-value: 3.29e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  31 TSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVIL-PIMIYAGLRSNQWGRSSCTINWPGESGAWYT 109
Cdd:cd15068  84 SSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLtPMLGWNNCGQPKEGKNHSQGCGEGQVACLFE 163
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 110 GFII------YTFILGFLVPLTIICLCYLFII------IKVKSSGIRVGSSKRKKSEKKV--TRMVSIVVAVFIFCWLPF 175
Cdd:cd15068 164 DVVPmnymvyFNFFACVLVPLLLMLGVYLRIFlaarrqLKQMESQPLPGERARSTLQKEVhaAKSLAIIVGLFALCWLPL 243
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 12652991 176 YIFNVSSVSMAISPTPALKGMFdFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15068 244 HIINCFTFFCPDCSHAPLWLMY-LAIVLSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
1-224 3.63e-11

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 62.16  E-value: 3.63e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIkSAKWRRPRTAKMItMAVWGVSLLVILPI 80
Cdd:cd15008  55 FVLLQFTSGRWTLGSAMCKLVRYFQYLTPGVQIYVLLSICVDRFYTIVYPL-SFKVSREKAKKMI-AASWLFDAAFVSPA 132
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGlrsNQWGRSSCTINWPGESGAWYTgfiIYTFILGFLVPLTIICLCYLFII-----IKVKSSGIRVGSSKRKKSEK 155
Cdd:cd15008 133 LFFYG---SNWGPHCNFFLPDSWDGAAYA---IIHLLVGFLVPSILIILFYQKVIkyiwrIGTDGRTVRRTMNIVPRTKV 206
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 156 KVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALkgMFDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15008 207 KTIKMFLMLNSMFLLSWLPFYVVQLWHPRESDYRQSSL--VFLAVTWISFSSSASKPTLYSVYNANFRR 273
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
9-215 4.29e-11

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 62.07  E-value: 4.29e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   9 VHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRpRTAKMITMAvWGVSLLVILP-IMIYAGLR 87
Cdd:cd15384  64 VAWLAGNTMCKLVKYLQVFGLYLSTYITVLISLDRCVAILYPMKRNQAPE-RVRRMVTVA-WILSPIFSIPqAVIFHVER 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  88 SNQWGRSSCTINWPGESGAW----YTGFiiyTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTR---- 159
Cdd:cd15384 142 GPFVEDFHQCVTYGFYTAEWqeqlYNML---SLVFMFPIPLVIMVTCYVLIFITLSKSSRDFQGLEIYTRNRGPNRqrlf 218
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12652991 160 ---------MVSIVVAVFIFCWLPFYIFNVssVSMAISPTPALKGMFDFVVVLTYANSCANPILY 215
Cdd:cd15384 219 hkakvkslrMSAVIVTAFILCWTPYYVIMI--WFLFFNPYPLNDILFDVIFFFGMSNSCVNPLIY 281
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
10-223 5.41e-11

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 61.35  E-value: 5.41e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKwRRPRTAKMITMAVWGVSLLVILPIMIY-AGLRS 88
Cdd:cd15370  65 NWIYGEALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMSHSR-KKANIAIGISLAIWLLILLVTIPLYLVkQTVFI 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRSSCTINWPGESGAWYT-GFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirVGSSKRKKSEKKVTRMVSIVVAV 167
Cdd:cd15370 144 PALDITTCHDVLPEQLLVGDMfNYFLSLAIGVFLFPAFLTAVAYVLMIRALKSS---INDESIEKKRKRAIKLIVTVLVM 220
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 168 FIFCWLPFYIF-NVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFK 223
Cdd:cd15370 221 YLICFTPSNLLlVVHYFLLKNQGQSSVYAFYITALCLSTLNSCIDPFVYYFVSHDFR 277
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
27-225 5.68e-11

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 61.35  E-value: 5.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  27 INQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSnqwgrSSCTINwpgesga 106
Cdd:cd15163  79 VNMYCSILFLTCICVDRYLAIVQVEASRRWRNPNYAKGICVFIWLFAIVVTFSILTTAIKFA-----SCCLSK------- 146
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 107 wytgfIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIrvgSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYifnVSSVSMA 186
Cdd:cd15163 147 -----LFALTVFEFFLPLLIITFFTIRIMCALSRPGL---MHQSRERRMRAVQLLITVLIIFMICFTPFH---VRQVAVA 215
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 12652991 187 ISPTPALKG---MFDFVVVLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15163 216 FNPDIPHHTsliVYHVTVTLSSLNSCMDPIVYCFVTNNFQST 257
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
11-224 5.94e-11

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 61.34  E-value: 5.94e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd15969  65 WNFNFFLCRYTSVLFYASMYTSIVFLGLISLDRYLKVVKPFGDSRMYSITFTKVLSACVWLIMAFLSLPNIILTNGQPTE 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCtINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRvgSSKRKKSEKKVTRMVSIVVAVFIF 170
Cdd:cd15969 145 DNIHDC-SKLKSPLGVKWHTAVSYINICIFVAVLVILIVCYISISRYIYKSSKQ--FISSSSRTRKHNQSIRVVVAVFFV 221
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 171 CWLPFYI----FNVSSVSMAISPT--PALKGMFDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15969 222 CFLPYHLcripFTFSQLDKILDCTikTILYYCKEATLFLSACNVCLDPIIYFFMCRSFSQ 281
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
32-226 6.73e-11

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 61.08  E-value: 6.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILPImiyAGLRSnqwgRSSCTINWPGESGAWY-T 109
Cdd:cd15136  94 SVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMaLLPL---VGVSS----YSKTSICLPFETETPVsK 166
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 110 GFIIYTFILGFLVPLtIICLCYLFIIIKVKSSgirvGSSKRKKSEKKVTRMVSIVVAVFIfCWLPFYIFNVSSVS--MAI 187
Cdd:cd15136 167 AYVIFLLLFNGLAFL-IICGCYIKIYLSVRGS----GRAANSNDTRIAKRMALLVFTDFL-CWAPIAFFGLTAAFglPLI 240
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 12652991 188 SPTPAlkgmfDFVVVLTYA-NSCANPILYAFLSDNFKKSF 226
Cdd:cd15136 241 SVSNA-----KILLVFFYPlNSCANPFLYAIFTKQFRRDC 275
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
32-226 6.81e-11

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 61.35  E-value: 6.81e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIKSAKWRrPRTAKMITMAVWGVSLL-VILPIMIYAGLRSNQWGrSSCTINWpgESGAWYT- 109
Cdd:cd15082 100 ALWSLAVLAFERFFVICRPLGNIRLQ-GKHAALGLLFVWTFSFIwTIPPVLGWSSYTVSKIG-TTCEPNW--YSGNMHDh 175
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 110 GFIIYTFILGFLVPLTIICLCYLFIIIKV-KSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSM-AI 187
Cdd:cd15082 176 TYIITFFTTCFILPLGVIFVSYGKLLQKLrKVSNTQGRLGNARKPERQVTRMVVVMIVAFMVCWTPYAAFSILVTAHpTI 255
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 12652991 188 SPTPALKGMFDFvvvLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15082 256 HLDPRLAAIPAF---FSKTAAVYNPIIYVFMNKQFRKCL 291
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
10-226 9.06e-11

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 60.74  E-value: 9.06e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGV-----SLLVILPIMIYA 84
Cdd:cd15170  66 IWPLPYFLCPLSSFIFFSTIYISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVFFWVLafshcSIVYIVEYHIDS 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  85 GLRSNQWGrSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYlFIIIKVKSSGIRVGSSKRKksekkvtRMVSIV 164
Cdd:cd15170 146 ENTSVTNN-SRCYDNFTPEQLKILLPVRLELFLVLFCIPFLITCFCY-INFIRILSSLPHISRQRKQ-------RAIGLA 216
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 165 VA---VFIFCWLPfyiFNVSSVSMAIS-PTPALKgmfDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15170 217 VAtllNFIVCFAP---YNISHVVGFIQrKSPEWR---MYALLLSTLNACLDPIIFYFSSSAVRRAF 276
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
2-226 1.06e-10

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 60.45  E-value: 1.06e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   2 LAMQVALV-----HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVhpikSAKWRRPRTAKMITM---AVWGVS 73
Cdd:cd15331  52 LVMPLSAVyevsqHWFLGPEVCDMWISMDVLCCTASILHLVAIALDRYWAVT----NIDYIRRRTAKRILImiaVVWFVS 127
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  74 LLVILPiMIYAGLRSNQWGR----SSCTINWPgesgawyTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirvgssk 149
Cdd:cd15331 128 LIISIA-PLFGWKDEDDLDRvlktGVCLISQD-------YGYTIFSTVGAFYVPLLLMIIIYWKIYQAAKRE-------- 191
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12652991 150 rkkseKKVTRMVSIVVAVFIFCWLPFYIFnvsSVSMAISPTPAL-KGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15331 192 -----RKAARTLAIITGAFVVCWLPFFLV---ALVMPFCGAWQIsRFLESFFLWLGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
16-224 1.20e-10

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 60.56  E-value: 1.20e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  16 AICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAvWGVSLLVILP-IMIYaglrSNQWGRS 94
Cdd:cd15388  71 VLCRLVKYLQVVGMFASSYMIVAMTFDRHQAICRPMVTFQKGRARWNGPVCVA-WAISLILSLPqVFIF----SKVEVAP 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  95 SCTINWPGESGAWYT-GFIIYTFILGFLVPLTIICLCYLFII------IKVKSSGIRVGSSKRKKSEKKVT--------- 158
Cdd:cd15388 146 GVYECWACFIEPWGLkAYVTWITLVVFVLPTLIITVCQVLIFkeihinIYLKSQIIVAVVKKKQLLSSRASsvaevskam 225
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 159 ----RMVSIVVAVFIFCWLPFYIFNVSSVsmaISPTPALKG-MFDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15388 226 iktvKMTLVIVLVYVLCWAPFFLVQLWSV---WDPKAPTEGaTFTILMLLASLNSCTNPWIYMAFSSSVSK 293
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
31-226 1.32e-10

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 60.72  E-value: 1.32e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  31 TSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVIL-PIMIYAGLRS------NQW----GRSSCTIN 99
Cdd:cd15069  84 SSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLtPFLGWNKAMSatnnstNPAdhgtNHSCCLIS 163
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 100 WPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIII----KVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPF 175
Cdd:cd15069 164 CLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLvacrQLQRTELMDHSRTTLQREIHAAKSLAIIVGIFALCWLPV 243
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 12652991 176 YIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15069 244 HILNCITLFQPEFSKSKPKWAMNVAILLSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
10-224 1.33e-10

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 60.54  E-value: 1.33e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd15147  67 NWILPKFLCNVAGCLFFINTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVASASYFLFMDSTNTV 146
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINWPG-ESGAWYTGFIIYTFILG-FLVPLTIICLCYLFIIIKVKSSGIRvgSSKRKKSEKKVTRMVSIVVAV 167
Cdd:cd15147 147 KIDSGNFTRCFEGyEKDNSKPVLIIHFIIIGlFFLVFLLILVCNLVIARTLLSQPVQ--GQRNAGVKRRALWMVCTVLAV 224
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12652991 168 FIFCWLPFYIFNVSSVSMAISPTP--------ALKGMFDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15147 225 FVICFVPHHVVQGPWTLAVLQQWRywdcqfrqALNDAHQITLCLMSTNCVLDPVIYCFLTKKFRK 289
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
11-226 1.71e-10

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 60.30  E-value: 1.71e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVvhpiksAKWRR------PRTAKMITMAVWGVSLLVILPIMI-Y 83
Cdd:cd15977  66 WPFGVHVCKLYPFIQKASVGITVLSLCALSIDRYRAV------ASWSRirgigiPVWKAVEVTLIWAVAIIVAVPEAIaF 139
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  84 AGLRSNQWGRSSCTINWPGESGAWYTGF---IIYTFILGFLVPLTIICLCYLFIIIKV----KSSGIRVGSSKRKKSEKK 156
Cdd:cd15977 140 DMVEIDYRGQTLLVCMLPMEQTSSFMRFyqdVKDWWLFGFYFCLPLACTGVFYTLMSCemlsIKNGMRIALNDHMKQRRE 219
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 157 VTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYA-------NSCANPILYAFLSDNFKKSF 226
Cdd:cd15977 220 VAKTVFCLVVIFALCWLPLHLSRILKKTIYDVKDPQRCELLSFLLVMDYTginmaslNSCINPVALYFVSRKFKNCF 296
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
11-226 1.95e-10

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 59.87  E-value: 1.95e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAV-----VHPIKSAKWrrprTAKMITMaVWGVSLLVILPIMI-YA 84
Cdd:cd15976  66 WPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVaswsrIKGIGVPKW----TAVEIVL-IWVVSIILAVPEAIgFD 140
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  85 GLRSNQWGR--SSCTINwPGESGAWYTGFIIYT----FILGFLVPLTIICLCYLFIIIKV--KSSGIRVGSSKRKKSEKK 156
Cdd:cd15976 141 MITMDYKGEllRICLLH-PIQKTAFMQFYKTAKdwwlFSFYFCLPLACTAVFYTLMTCEMlrKKNGMQIALNDHLKQRRE 219
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 157 VTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTY-------ANSCANPILYAFLSDNFKKSF 226
Cdd:cd15976 220 VAKTVFCLVLVFALCWLPLHLSRILKLTIYDEKDPNRCELLSFFLVLDYiginmasLNSCINPIALYLVSKRFKNCF 296
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
12-225 2.05e-10

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 59.78  E-value: 2.05e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  12 PFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQw 91
Cdd:cd15219  67 PFGDGFCQAVGFLETFLTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLVALFLSWLGYSS- 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  92 GRSSCTINWPGES-GAWYTGFIIYTFILGFLVPLTIICLCYLfIIIKVKSSgirvgsskrkkseKKVTRMVSIVVAVFIF 170
Cdd:cd15219 146 LYASCTLHLPREEeRRRFAVFTAFFHAFTFLLSLLVLCVTYL-KVLKVRRR-------------QRATKKISIFIGTFVL 211
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12652991 171 CWLPfYIFNVSSVSMAISPTPALKGMFDfvVVLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15219 212 CFAP-YVITRLVELLPFVTINRYWGIVS--KCLTYSKAASDPFVYSLLRQQYRKV 263
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
11-216 2.95e-10

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 59.35  E-value: 2.95e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIM------IYA 84
Cdd:cd15336  66 WIFGEKGCELYAFCGALFGITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLfgwsayVPE 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  85 GLrsnqwgRSSCTINWPGESGAwYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKK-------- 156
Cdd:cd15336 146 GL------LTSCTWDYMTFTPS-VRAYTMLLFCFVFFIPLGIIIYCYLFIFLAIRSTGREVQKLGSQDRKEKakqyqrmk 218
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12652991 157 ----VTRMVSIVVAVFIFCWLPFYIFN-VSSVSMAISPTPALKGMfdfVVVLTYANSCANPILYA 216
Cdd:cd15336 219 newkMAKIAFVVILLFVLSWSPYACVAlIAWAGYAHLLTPYMKSV---PAVIAKASAIYNPIIYA 280
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
11-218 3.80e-10

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 59.18  E-value: 3.80e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICR---VVMTVDGinqFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILPIMiyaGL 86
Cdd:cd14981  69 WDGGQPLCDyfgFMMSFFG---LSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIaSLPLL---GL 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  87 RSN--QWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIIC-------LCYLFIIIKVKSSGIRVGSSKRKKSEKKV 157
Cdd:cd14981 143 GSYvlQYPGTWCFLDFYSKNTGDAAYAYLYSILGLLILLVTLLCnllviitLLRMRRRKKRHRRSRRSARRQKRNEIQMV 222
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12652991 158 TRMVSIVVaVFIFCWLPFYIFnvssVSMAISPTPALKGMFDFVVV-LTYANSCANPILYAFL 218
Cdd:cd14981 223 VLLLAITV-VFSVCWLPLMIR----VLINATGDSEKNGKTDLLAVrMASWNQILDPWVYILL 279
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
11-226 4.34e-10

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 59.04  E-value: 4.34e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMItMAVWGVSLLVILPIMIYAGL---- 86
Cdd:cd15135  71 TPSGNIACKIYNFLFEACSYATILNVATLSFERYIAICHPFKYKALSGSRVRLLI-CFVWLTSALVALPLLFAMGTedpl 149
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  87 ----------------RSNQWGRSSCTINWPGESGAWYTGFIIYtfiLGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKR 150
Cdd:cd15135 150 eafpsyrgtrhhcqdqKSNLTICTSLSSKWTVFQASIFSAFVLY---LLVLASVAFMCRRMMRALMGSKKGAVAVKGPGG 226
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 151 KKSEKK-------------VTRMVSIVVAVFIFCWLPFYIFNVSSVsmAISPTPALKGMFDFVVVLT-------YANSCA 210
Cdd:cd15135 227 SVQLLRkhesaegktarkqTILFLGLIVGTLAVCWMPNQIRRIMAA--AKPKDDWTRSYFRAYIILLpiadtffYLSSVL 304
                       250
                ....*....|....*.
gi 12652991 211 NPILYAFLSDNFKKSF 226
Cdd:cd15135 305 NPLLYNLSSQQFRSVF 320
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
11-221 4.60e-10

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 59.01  E-value: 4.60e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKsAKWRRPRTAKMItMAVWGVSLLVILPIMIYAGLRS-- 88
Cdd:cd15212  67 WLFGDRLCLANGFFNACFGIVSTLTMTLISFDRYYAIVRQPQ-GKIGRRRALQLL-AAAWLTALGFSLPWYLLASAPEyy 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRV------GSSKRKKSEKKVTRMVS 162
Cdd:cd15212 145 EKLGFYHCLYVLHSGPSRLGAAYSSVLIVLCYLLPFALMCFCHYNICKTVRLSESRVrpvttyAHLLRFYSEMRTATTVL 224
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 163 IVVAVFIFCWLPFYIFNVSSVSMAISPTPALkgmfDFVVV-LTYANSCANPILYAFLSDN 221
Cdd:cd15212 225 IMIVFIICCWGPYCLLGLVAAAGGYQFPPLM----DTVAIwMAWANGAINPLIYAIRNPN 280
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
11-226 5.05e-10

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 58.72  E-value: 5.05e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLR--- 87
Cdd:cd15356  71 WVFGDLVCRGYYFVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALPMAFIMGQKyel 150
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  88 --SNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCylfiiikvksSGIRVGSSKRKKSEKKVTRMVSIVV 165
Cdd:cd15356 151 etADGEPEPSSRVCTVLVSRATLKVFIQVNAFVSFVLPLALIAFL----------NGVTVSHLRIQSLQHSVQVLRAIVI 220
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 166 AvFIFCWLPFYIFNVSSVSMAISP-TPALKGMFDFVVVLT----YANSCANPILYAFLSDNFKKSF 226
Cdd:cd15356 221 A-YVICWLPYHARRLMFCYVPDDAwTDSLYNFYHYFYMLTntlfYVSSAVNPLLYNVVSSSFRKLF 285
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
10-226 5.50e-10

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 58.44  E-value: 5.50e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIY----AG 85
Cdd:cd15297  65 YWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFwqfiVG 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  86 LRSNQWGRssCTINWPGESGAWYTgfiiyTFILGFLVPLTIICLCYlFIIIKVKSSGIRvgsskrkksekkVTRMVSIVV 165
Cdd:cd15297 145 GRTVPEGE--CYIQFFSNAAVTFG-----TAIAAFYLPVIIMTVLY-WQISRASSREKK------------VTRTILAIL 204
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 166 AVFIFCWLPfyiFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15297 205 LAFIITWTP---YNVMVLINTFCASCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTF 262
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
11-226 6.29e-10

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 58.31  E-value: 6.29e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIyaGLrSNQ 90
Cdd:cd15308  67 WTLSPVLCDALMTMDVMLCTASIFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVASPVIF--GL-NNV 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSsctinwPGESGAWYTGFIIYTFILGFLVPLTIICL--CYLFIIIKVKSSGIRVgsskrkksekkvtrmVSIVVAVF 168
Cdd:cd15308 144 PNRD------PAVCKLEDNNYVVYSSVCSFFIPCPVMLVlyCAMFRGLGRERKAMRV---------------LPVVVGAF 202
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 169 IFCWLPFYIFNVSSV---SMAISPTpalkgMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15308 203 LFCWTPFFVVHITRAlceSCSIPPQ-----LISIVTWLGYVNSALNPVIYTVFNAEFRNVF 258
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
32-225 6.79e-10

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 58.30  E-value: 6.79e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITmAVWGVSLLV-ILPIMIYAGLRSNQwgrsSCTINWPgesgaWYTG 110
Cdd:cd15348  86 SVFSLLAIAIERHITMVRMKPYPGDKRGRMFLLIG-AAWLVSILLgVLPILGWNCLGNLD----ACSTVLP-----LYAK 155
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 111 FIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEK-------KVTRMVSIVVAVFIFCWLPFYIFNVSSV 183
Cdd:cd15348 156 SYILFCITVFLAILAAIVVLYARIYRIVKANSQRLGALPTRKGRArrsqkylALLKTVTIVLGTFVACWLPLFLLLLLDV 235
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 12652991 184 SMAISPTPALKGMfDFVVVLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15348 236 SCPAQACPVLLKA-DYFLGLAMINSLLNPIIYTLTSRDMRRA 276
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
10-224 7.81e-10

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 58.20  E-value: 7.81e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRpRTAKMITMAVWGVSLLVILPIMIyagLRSN 89
Cdd:cd15152  64 SWPFGKFLCMFCFYLKYVNMYASIYFLVCISVRRCLYLIYPFRYNDCKR-KCDVYISIAGWLVVCVGCLPFPL---LRQS 139
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWG-RSSCTINWPGESGAWYTGFIIYTF--ILGFLVPLTIICLCYLFIIIKVKSsgiRVGSSKRKKSEKKVTRMVSIVVA 166
Cdd:cd15152 140 QDTnPTCCFADLPLRNVGLTTSVIMLTIaeLTGFVTPLLIVLYCSWKTVMSLRE---KTPVLQDLGEKKKALKMILTCAV 216
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12652991 167 VFIFCWLPFYI---FNVSSVSMAISPTPALKGMFDFVVV---LTYANSCANPILYAFLSDNFKK 224
Cdd:cd15152 217 VFLICFAPYHIsfpLDFLVKSNKIKSCTARKVILIFHPValcLASLNSCLDPVIYYFTTDEFKR 280
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
11-224 7.97e-10

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 58.25  E-value: 7.97e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd15151  65 WQLRAFVCRFSAVVFYITMYISIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFLLSVPNMILSNKPATP 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTiNWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRmVSIVVAVFIF 170
Cdd:cd15151 145 ISVKKCA-SLKSPLGLKWHEVVNYICQFIFWGVFALMVLFYTIISKKVYESYKKSRSKDNKASKKTKAK-VFIIVAVFFV 222
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 171 CWLPF------YIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15151 223 CFAPFhfvrvpYTLSQTGKITDCQLQNLLYIAKEITLWLAATNVCLDPLIYIFLCKSFRQ 282
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
11-224 9.72e-10

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 57.94  E-value: 9.72e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd15149  65 WQLNVIVCRYSAVIFYLNMYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVGYSKALSVVVWMLMAVLSVPNIILTNQSFHE 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCtINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVaVFIF 170
Cdd:cd15149 145 ANYTKC-ARLKSELGIQWHKASNYICVSIFWVVFLLLIIFYVAISRKIYKSNQKFRRNSTNMKAKSSRNIFSILF-VFFV 222
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 171 CWLPFYIFNV------SSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15149 223 CFVPYHALRIpytlsqTGADYSCQSKTILYYMKEFTLLLSAANVCLDPIIYFFLCQPFRE 282
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
32-225 1.18e-09

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 57.56  E-value: 1.18e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMaVWGVSLL-VILPIMIYAGLrSNQWGRSSCTINWPGESGAWYTG 110
Cdd:cd15085  87 SLWSLTLLAYERYNVVCKPMGGLKLSTKRGYQGLLF-IWLFCLFwAVAPLFGWSSY-GPEGVQTSCSIGWEERSWSNYSY 164
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 111 FIIYtFILGFLVPLTIICLCYLFIIIKVKSSGIRV---GSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSV---S 184
Cdd:cd15085 165 LILY-FLMCFVIPVAIIGFSYGNVLRSLHKLNKKIeqqGGKNCPEEEERAVIMVLAMVIAFLICWLPYTVFALIVVvnpE 243
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 12652991 185 MAISPTPALKGMFdfvvvLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15085 244 LSISPLAATMPTY-----FAKTSPVYNPIIYIFLNKQFRES 279
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
32-226 1.56e-09

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 57.14  E-value: 1.56e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAvWGVS-LLVILPIMIYAGLRSnqwgRSSCTINWPGESGAwYTG 110
Cdd:cd15345  86 STFSLLAIAIERHLTMIKMRPYDANKRYRVFLLIGTC-WLISvLLGALPILGWNCLDN----LPDCSTILPLYSKK-YVA 159
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 111 FIIYTFIlgflVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPT 190
Cdd:cd15345 160 FCISIFI----AILVAIVILYARIYILVKSSSRRVTNHRNSERSMALLRTVVIVVGVFIACWSPLFILLLIDVACEVKQC 235
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 12652991 191 PALKGMfDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15345 236 PILYKA-DWFIALAVLNSAMNPIIYTLASKEMRRAF 270
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
1-226 1.98e-09

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 57.18  E-value: 1.98e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILP 79
Cdd:cd15957  56 FGAAHILLKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTsFLP 135
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  80 IMIYaGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFI-------IIKVKSSGIRVGSSKRKK 152
Cdd:cd15957 136 IQMH-WYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVfqeakrqLQKIDKSEGRFHNQNIDQ 214
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 153 SEKK-----------------VTRMVSIVVAVFIFCWLPFYIFNVSSVsmaISPTPALKGMFDFVVVLTYANSCANPILY 215
Cdd:cd15957 215 NGSGggggnrrrskfclkehkALKTLGIIMGTFTLCWLPFFIVNIVHV---IQDNLIRKEVYILLNWIGYVNSGFNPLIY 291
                       250
                ....*....|.
gi 12652991 216 AfLSDNFKKSF 226
Cdd:cd15957 292 C-RSPDFRIAF 301
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
10-226 2.14e-09

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 57.11  E-value: 2.14e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMI-YAGLRS 88
Cdd:cd15056  65 RWIYGETFCLVRTSLDVLLTTASIMHLCCIALDRYYAICCQPLVYKMTPLRVAVMLGGCWVIPTFISFLPIMQgWNHIGI 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVK------SSGIRVGSSKRKKSEKKVTRM-- 160
Cdd:cd15056 145 EDLIAFNCASGSTSCVFMVNKPFAIICSTVAFYIPALLMVLAYYRIYVAAReqahqiRSLQRAGSSNHEADQHRNSRMrt 224
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12652991 161 -------VSIVVAVFIFCWLPFYIFNVssVSMAISPTPALKgMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15056 225 etkaaktLGIIMGCFCVCWAPFFVTNI--VDPFIGYRVPYL-LWTAFLWLGYINSGLNPFLYAFFNKSFRRAF 294
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
10-226 2.89e-09

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 56.28  E-value: 2.89e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKsAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd15086  65 RWLIGEHGCRWYGFANSLFGIVSLISLAVLSYERYCTLLRPTE-ADVSDYRKAWLGVGGSWLYSLLWTLPPLLGWSSYGP 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINWPGESGAwYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGiRVGSSKRKKSEKKVTRMVSIVVAVFI 169
Cdd:cd15086 144 EGPGTTCSVQWTSRSAN-SISYIICLFIFCLLLPFLVMVYCYGRLLYAIKQVG-KINKSTARKREQHVLLMVVTMVICYL 221
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12652991 170 FCWLPFYIfnvssvsMAISPTPALKGMFDFVV-----VLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15086 222 LCWLPYGV-------MALLATFGKPGLVTPVAsivpsILAKSSTVVNPIIYVFMNKQFYRCF 276
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
5-219 6.81e-09

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 55.34  E-value: 6.81e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   5 QVALVHWPfGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIksakW---RRPRTAKMITMA-VWGVSLLVILPI 80
Cdd:cd14973  59 DLLGGSLP-GFALCRLLATLMFFSYTVGLSLLAAISTERCLSVLFPI----WyrcHRPKHLSAVVCAlLWALSLLLSVLE 133
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLrsnqwgrsscTINWPGESGAWYTGFIIYTFilgFLVPLTIICLCYLFIIIKVKSSGIRvgsskrkKSEKKVTRM 160
Cdd:cd14973 134 SYFCGF----------LFWKFNESACRTFNFLSALL---FLLLFLVMCVSSLTLLIRVQCSSQR-------RPPTRLYVV 193
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12652991 161 VSIVVAVFIFCWLPFYIfnvssvsmAISPTPALKGM--FDFVVVLTY---ANSCANPILYAFLS 219
Cdd:cd14973 194 ILLTVLVFLLCGLPLGI--------YWFLLLWFSNYlfHTFHPISDLlscVNSSANPIIYFFVG 249
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
32-223 7.99e-09

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 55.22  E-value: 7.99e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIKSAKWRRPRtAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYT-G 110
Cdd:cd15080  87 ALWSLVVLAIERYVVVCKPMSNFRFGENH-AIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNeS 165
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 111 FIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKK-VTRMVSIVVAVFIFCWLP-----FYIF-----N 179
Cdd:cd15080 166 FVIYMFVVHFTIPLIVIFFCYGRLVCTVKEAAAQQQESATTQKAEKeVTRMVIIMVIAFLICWVPyasvaFYIFthqgsD 245
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 12652991 180 VSSVSMAIsptPALkgmfdfvvvltYANSCA--NPILYAFLSDNFK 223
Cdd:cd15080 246 FGPIFMTI---PAF-----------FAKSSAvyNPVIYILMNKQFR 277
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
13-223 1.33e-08

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 54.45  E-value: 1.33e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  13 FGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRtAKMITMAVWGVSLLVILPIMIYAGLRSNQWG 92
Cdd:cd15077  68 LGPLACKIEGFTATLGGMVSLWSLAVVAFERFLVICKPLGNFTFRGTH-AIIGCIATWVFGLAASLPPLFGWSRYIPEGL 146
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  93 RSSCTINWPGESGAWYT-GFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGI-RVGSSKRKKSEKKVTRMVSIVVAVFIF 170
Cdd:cd15077 147 QCSCGPDWYTTNNKWNNeSYVMFLFCFCFGVPLSIIVFSYGRLLLTLRAVAKqQEQSASTQKAEREVTKMVVVMVLGFLV 226
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 12652991 171 CWLPFYIFNVSSVSMAISPTPAlkGMFDFVVVLTYANSCANPILYAFLSDNFK 223
Cdd:cd15077 227 CWLPYASFALWVVTNRGEPFDL--RLASIPSVFSKASTVYNPVIYVFMNKQFR 277
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
10-226 1.51e-08

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 54.26  E-value: 1.51e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIY----AG 85
Cdd:cd15298  65 YWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFwqfvVG 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  86 LRSNQWGRssCTINWPGESGAWYTgfiiyTFILGFLVPLTIICLCYLFIIIKVKSSgirvgsskrkkseKKVTRMVSIVV 165
Cdd:cd15298 145 KRTVPDNQ--CFIQFLSNPAVTFG-----TAIAAFYLPVVIMTVLYIHISLASARE-------------RKVTRTIFAIL 204
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 166 AVFIFCWLPfyiFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15298 205 LAFILTWTP---YNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTF 262
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
11-225 1.93e-08

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 53.93  E-value: 1.93e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYA--GLRS 88
Cdd:cd15148  66 WTLGPLLCKVVGNLFYMNMYISIILLGFISLDRYLKINRSSRRQKFLTRKWSIVACGVLWAVALVGFVPMIVLTekNEES 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  89 NQWGRSSCTINWPGEsgAWYTGFIIYTFILGFLVpltiICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVF 168
Cdd:cd15148 146 TKCFQYKDRKNAKGK--AIFNFLIVAMFWLVFLL----LILSYGKIAKKLLRISRDKPDFPNAAKYNRTARKSFFVLFIF 219
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12652991 169 IFCWLPFYIFNVSSVSMAISPTPA-LKGMFD----FVVVLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15148 220 TVCFVPYHAFRIFYITSQLQNNSCyWKEILHktneIMLLLSAFNSCLDPVMYFLLSSSIRKV 281
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
32-226 2.09e-08

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 54.01  E-value: 2.09e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIKsakWRRPRTAKMITMAV---WGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWY 108
Cdd:cd15070  85 SIMSLLAIAVDRYLRVKLTVR---YRIVTTQRRIWLALglcWLVSFLVGLTPMFGWNRKPSLESVNTTPLQCQFTSVMRM 161
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 109 TGFIIYTFILGFLVPLTIICLCYL--FIIIKVK----SSGIRvGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSS 182
Cdd:cd15070 162 DYMVYFSFFTWILIPLVIMCALYVdiFYIIRNKlsqnATGFR-ETGAFYGREFKTAKSLALVLFLFAVCWLPLSIINCVV 240
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 12652991 183 VSMAISPTPALKgmfdFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15070 241 YFNPKVPKIALY----LGILLSHANSMMNPIVYACKIKKFKETY 280
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
2-226 2.31e-08

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 54.06  E-value: 2.31e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   2 LAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVvhpiksAKWRRPR-------TAKMITMaVWGVSL 74
Cdd:cd15128  62 LAMDWPFGDQPFGQFLCKLVPFIQKASVGITVLNLCALSVDRYRAV------ASWSRIQgigipmwTAVEIVM-IWMLSA 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  75 LVILPIMI-YAGLRSNQWGR--SSCTINWPGESGAWYTGFI-IYTFILGFLVPLTIICLCYLFI---IIKVKSSGIRVGS 147
Cdd:cd15128 135 VLAVPEAIgFDMVRFNYKGVtlRTCLLRPETSFMKFYIDVKdWWLFGFYFCLPLVCTAIFYTLMtceMLRKRNGMLRIAL 214
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 148 SKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTY-------ANSCANPILYAFLSD 220
Cdd:cd15128 215 NEHLKQRREVAKTVFCLVVIFALCWLPLHLSRILKLTVYDQNDPNRCELLSFLLVLDYfginlatLNSCINPIALYFVSR 294

                ....*.
gi 12652991 221 NFKKSF 226
Cdd:cd15128 295 KFKNCF 300
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
11-226 2.90e-08

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 53.31  E-value: 2.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQ 90
Cdd:cd15215  65 WPLDSHLCTALVVLMHLFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYGWGQAAFD 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTINWpgesGAWYTgFIIYTFILGFLVPLTIICLCYLFIIIKVKSsgirvgsskrkKSEKKVTRMVSIVVAVFIF 170
Cdd:cd15215 145 ERNALCSVIW----GSSYS-YTILSVVSSFVLPVIIMLACYSMVFRAARR-----------CYHCKAAKVIFIIIFSYVL 208
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 171 CWLPFYIFNVSSVSMAISPTPALKGMfdfVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15215 209 SMGPYSFLSVLAVWVDTQVPQWVISI---ILWLFFLQCCIHPYIYGYMHKSIKKEF 261
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
11-226 4.81e-08

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 52.88  E-value: 4.81e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMT----VDGINQFTSIFCLTVMSIDRYLAVVHPIKS----------------AKWRRPRTAKMITMAVW 70
Cdd:cd14996  66 WKYQSTQCRIANFfgtlVIHVSMCVSILILSWIAISRYATLMKHDSAtqkqscyekifyghflKRFRQPKFARYLCIYIW 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  71 GVSLLVILPIMIYAGLRSNQWGRSSCTINWP---GESGAWYTGFIIYTFIlgFLVPLTIICLcYLFIIIKVKSSGIRVGS 147
Cdd:cd14996 146 GVVLCIIIPVVVYYSVREADEDGESLCYNRQvelGAKGSQIAGLIATTFF--FLFFLVVLLS-YYSFVNHLRRIQKNTCI 222
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 148 SKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMF----DFVVVLTYANSCANPILYAFLSDNFK 223
Cdd:cd14996 223 SEKDLIYRSVKRNILIIQALLVVCFLPYHIFKPVFYVLHQREDCQQLNYLietkNILTCLASARSSTDPIMYLLLDKTFK 302

                ...
gi 12652991 224 KSF 226
Cdd:cd14996 303 KTL 305
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
11-223 6.65e-08

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 52.50  E-value: 6.65e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKsakwrRPRTAKMITMAVWGVSLLVILPIMIYagLRSNQ 90
Cdd:cd15198  67 WMAGDVACRLLKLLQASARGASANLVVLLALDRHQAIRAPLG-----QPLRAWKLAALGWLLALLLALPQAYV--FRVDF 139
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 wgRSSCTINWPGES---------GAWY-TGFIIYTFILGFLVPLTIICLCYLFIIIKV-----KSSGIRVGSSKRKKSEK 155
Cdd:cd15198 140 --PDDPASAWPGHTlcrgifaplPRWHlQVYATYEAVVGFVAPVVILGVCYGRLLLKWweranQAPGAKKPWKKPSKSHL 217
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 156 KVT-------------RMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPalKGMFDFVVVLTYANSCANPILYAFLSDNF 222
Cdd:cd15198 218 RATapsalprakvktlKMTLVIALLFVGCSLPYFIAELAAAFGSGDWEP--EKVAAALGVMAVANSATNPFVFLFFNAGD 295

                .
gi 12652991 223 K 223
Cdd:cd15198 296 C 296
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
32-226 6.69e-08

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 52.38  E-value: 6.69e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGrSSCtinwpGESGAWYTGF 111
Cdd:cd15104  87 SVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLISPQFQQTSYK-GKC-----SFFAAFHPRV 160
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 112 IIYTFILGFLVPLTIICLCYLFI----------IIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIfnVS 181
Cdd:cd15104 161 LLVLSCMVFFPALLLFVFCYCDIlkiarvhsraIYKVEHALARQIHPRRTLSDFKAARTVAVLIGCFLLSWLPFQI--TG 238
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 12652991 182 SVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15104 239 LVQALCDECKLYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
1-225 7.35e-08

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 52.54  E-value: 7.35e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVhpiKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd15403  56 FTAVTIITVDWHFGAHFCRISAMLYWFFVLEGVAILLIISVDRFLIIV---QRQDKLNPHRAKVMIAISWVLSFCISFPS 132
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLRSNQWGRSSCTINWPgESGAwYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRM 160
Cdd:cd15403 133 VVGWTLVEVPARAPQCVLGYT-ESPA-DRVYAVLLVVAVFFVPFSIMLYSYLCILNTVRRNAVRIHNHADSLCLSQVSKL 210
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 161 ------------------------VSIVVAVFIFCWLPFYIFNVSSV-SMAISPTPALKGMFDFVVVLTYANSCANPILY 215
Cdd:cd15403 211 glmglqrphqmnvdmsfktrafttILILFVGFSLCWLPHTVFSLLSVfSRRFYYSSSFYPISTCVLWLSYLKSVFNPVIY 290
                       250
                ....*....|
gi 12652991 216 AFLSDNFKKS 225
Cdd:cd15403 291 CWRIKKFREA 300
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
13-218 9.45e-08

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 51.68  E-value: 9.45e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  13 FGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILPIMIY-AGLRSNQ 90
Cdd:cd15220  67 FGEAECRVYIFLSVCLVSASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLgLLPVLGWpSYGGPAP 146
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  91 WGRSSCTINWPGesGAWYTGFIIYTFILGFLVPLTIICLCYLFIIiKVKSSGirvgsskrkksekKVTRMVSIVVAVFIF 170
Cdd:cd15220 147 IAARHCSLHWSH--SGHRGVFVVLFALVCFLLPLLLILVVYCGVF-KVFGGG-------------KAALTLAAIVGQFLC 210
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 12652991 171 CWLPFYIFNvssVSMAISPTPALKGMFDFVVV-LTYANSCANPILYAFL 218
Cdd:cd15220 211 CWLPYFAFH---LYSALAASPVSGGEAEEVVTwLAYSCFAVNPFFYGLL 256
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
32-225 1.22e-07

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 51.71  E-value: 1.22e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILPIMIYAGLRSNQwgrsSCTINWPGESgawyTG 110
Cdd:cd15349  86 STFSLLVTAVERYATMVRPVAENTATKTYRVYGMIVLCWILAFLIgFLPLLGWNCLCDFR----SCSSLLPLYS----KS 157
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 111 FIIYTFILGFLVPLTIICLcYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPT 190
Cdd:cd15349 158 YILFCLVIFFIILLTIIGL-YFAIYCLVRASGQRVISARSRRRSLRLLKTVLMILGAFMVCWGPLFILLLVDFFCSSRSC 236
                       170       180       190
                ....*....|....*....|....*....|....*
gi 12652991 191 PALKGMfDFVVVLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15349 237 KPLFGM-EWVLALAVLNSAINPLIYSFRSLEVRRA 270
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
11-226 1.37e-07

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 51.33  E-value: 1.37e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIK-SAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd15296  66 WKFGRGLCKLWLVVDYLLCTASVFNIVLISYDRFLSVTRAVSyRAQKGMTRQAVLKMVLVWVLAFLLYGPAIISWEYIAG 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QwgrsscTINWPGESGA-----WYtgFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGsskrkkSEKKVTRMVSIV 164
Cdd:cd15296 146 G------SIIPEGECYAeffynWY--FLMTASTLEFFTPFISVTYFNLSIYLNIQKRRFRLS------RDKKVAKSLAII 211
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12652991 165 VAVFIFCWLPFYIFNVssVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15296 212 VCVFGLCWAPYTLLMI--IRAACHGHCVPDYWYETSFWLLWVNSAINPVLYPLCHMSFRRAF 271
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
18-223 2.37e-07

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 50.91  E-value: 2.37e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  18 CRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCt 97
Cdd:cd15167  73 CQVTACLIYINMYLSIIFLGFVSIDRYLQLTHSSKLYRIQEPGFAKMISAVVWTLVLFIMVPNMAIPIKTIEEKPGVGC- 151
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  98 INWPGESGA-WY--TGFIIYTFILGFlvplTIICLCYLFIIIKvksSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLP 174
Cdd:cd15167 152 ADFKTEFGRhWHvlTNFICMAIFLNF----SAIILISNFLVIR---KLYRNKDSEEYRNARQALVNILLVTAGYVICFVP 224
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12652991 175 FYIFNVS---SVSMAISPTPALKGMF---DFVVVLTYANSCANPILYAFLSDNFK 223
Cdd:cd15167 225 YHIVRIPytlSQSEVITDCSLKRSLFlakESTLLLAVLNLCFDPILYFHLSKAFR 279
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
1-225 3.00e-07

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 50.54  E-value: 3.00e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIksAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd15398  56 FTLTCVLLDQWIFGEVMCHIVPFLQCVSVMVSTLMLMSIAIVRYHMIKHPL--SNHLTANHGYFLLGTVWTLGFTICSPL 133
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGL--------RSNQWGRSSCTINWPgeSGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSgirvgsskrkk 152
Cdd:cd15398 134 PVFHKIvdlsetfnLESLKNKYLCIESWP--SDSYRIAFTISLLFVQYILPLVCLTVSHTSVCRSVKRS----------- 200
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12652991 153 seKKVTRMVSIVVAVFIFCWLPFYIFN-VSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15398 201 --RSVFYRLTIVILAFAVSWMPLHLFHlVTDFNANLISNRHFKLVYCICHLLGMLSCCLNPILYGFLNNGIKSD 272
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
10-226 3.19e-07

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 50.41  E-value: 3.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMI----YAG 85
Cdd:cd15300  65 YWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPILcwqyFVG 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  86 LRSNQwgRSSCTINWPGESGAWYTgfiiyTFILGFLVPLTIICLCYLFI---IIKVKSSGirvgsskrkksekkvtRMVS 162
Cdd:cd15300 145 KRTVP--ERECQIQFLSEPTITFG-----TAIAAFYIPVSVMTILYCRIykeTIKERKAA----------------QTLS 201
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12652991 163 IVVAVFIFCWLPFYIFNVssVSMAISPTPALKgMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15300 202 AILLAFIITWTPYNIMVL--VSTFCSDCIPLT-LWHLGYWLCYVNSTVNPMCYALCNKTFRKTF 262
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
1-215 4.88e-07

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 49.84  E-value: 4.88e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHpiKSAKWRrPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd15404  56 FALVTIITTRWIFGDAFCRVSAMFFWLFVMEGVAILLIISIDRFLIIVQ--KQDKLN-PYRAKVLIAVSWAVSFCVAFPL 132
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLRSNQWGRSSCTINWPGESGawYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSkrkksekkvtrm 160
Cdd:cd15404 133 AVGSPDLQIPSRAPQCVFGYTTNPG--YQAYVILIMLIFFFIPFMVMLYSFMGILNTVRSFKTRAFTT------------ 198
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 161 VSIVVAVFIFCWLPFYIFN-VSSVSMAISPTPALKGMFDFVVVLTYANSCANPILY 215
Cdd:cd15404 199 ILILFIVFTVCWAPFTTYSlVATFNSHFYHKHNFFEISTWLLWLCYLKSALNPLIY 254
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
10-230 6.19e-07

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 49.56  E-value: 6.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAglrsn 89
Cdd:cd15299  68 RWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFW----- 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINwPGESGAWYTGFIIYTF---ILGFLVPLTIICLCYLFI---IIKVKSSGirvgsskrkksekkvtRMVSI 163
Cdd:cd15299 143 QYFVGKRTVP-PDECFIQFLSEPIITFgtaIAAFYLPVTIMTILYWRIykeTIKEKKAA----------------QTLSA 205
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 164 VVAVFIFCWLPFYIFnVSSVSMAISPTPalKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVL 230
Cdd:cd15299 206 ILLAFIITWTPYNIM-VLVNTFCDSCIP--KTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLL 269
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
32-226 8.53e-07

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 49.07  E-value: 8.53e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIK-SAKWRRPRtAKMITMAVWGVSLLV-ILPIMiyaGLRSNQWgRSSCTINWPGESGAWYT 109
Cdd:cd15099  87 SVGSLLLTALDRYLCIYQPSNyKLLVTRTR-AKVAILLMWCVTIIIsFLPLM---GWRCKTW-DSPCSRLFPYIDRHYLA 161
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 110 GFIIYTFILgflvpLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKK----------VTRMVSIVVAVFIFCWLPFYIFN 179
Cdd:cd15099 162 SWTGLQLVL-----LFLIIYAYPYILWKAHRHEANMGGPKLGRQQVKgqarmrmdirLAKTLSLILLVLAICWLPVLAFM 236
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 12652991 180 VSSVSMAIspTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15099 237 LVDVRVTL--TNKQKRMFAFCSMLCLVNSCVNPIIYALRSRELRGAM 281
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
38-223 1.08e-06

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 48.62  E-value: 1.08e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  38 VMSIDRYLAVVHPIKSAKWRrPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAwYTGFIIYTFI 117
Cdd:cd15075  93 VIAVDRLFVVCKPLGTLTFQ-TRHALAGIASSWLWSLIWNTPPLFGWGSYQLEGVMTSCAPDWYSRDPV-NVSYILCYFS 170
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 118 LGFLVPLTIICLCY---LFIIIKVKSSGIRVGSSKRKKSEKkVTRMVSIVVAVFIFCWLPFYIFNVSSVS---MAISPTP 191
Cdd:cd15075 171 FCFAIPFAIILVSYgylLWTLRQVAKLGVAEGGSTAKAEVQ-VARMVVVMVMAFLLCWLPYAAFALTVVSkpdVYINPLI 249
                       170       180       190
                ....*....|....*....|....*....|..
gi 12652991 192 ALKGMFdfvvvLTYANSCANPILYAFLSDNFK 223
Cdd:cd15075 250 ATVPMY-----LAKSSTVYNPIIYIFMNKQFR 276
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
11-79 1.79e-06

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 48.22  E-value: 1.79e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILP 79
Cdd:cd15005  67 WIYGALSCKVIAFLAVLFCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFP 135
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
32-224 2.35e-06

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 47.59  E-value: 2.35e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVS-LLVILPImiyagLRSNQWGRSSCTINWPGESGAwYTG 110
Cdd:cd15964  94 SVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCfLLALLPL-----VGVSSYAKVSICLPMDTETPL-AQA 167
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 111 FIIYTFILGfLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKsekkVTRMVSIVVAVFIfCWLPFYIFNVSSVSMaiSPT 190
Cdd:cd15964 168 YIVFVLMLN-IIAFVIICACYIKIYITVRNPQYKSGDKDTKI----AKRMAVLIFTDFI-CMAPISFYALSAILN--KPL 239
                       170       180       190
                ....*....|....*....|....*....|....
gi 12652991 191 PALKGMFDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15964 240 ITVSNSKILLVLFYPLNSCANPFLYAIFTKAFRR 273
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
1-226 3.29e-06

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 47.55  E-value: 3.29e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVvhpiksAKWRR------PRTAKMITMAVWGVSL 74
Cdd:cd15975  61 LLAQKWPFDDSSFGVFLCKLVPFLQKASVGITVLNLCALSVDRYRAV------ASWSRvqgigiPLITAIEIFSIWVLSF 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  75 LVILP---IMIYAGLRSNQWGRSSCTINWPGESGAWYTGFI-IYTFILGFLVPLTIICLCYLFI---IIKVKSSGIRVGS 147
Cdd:cd15975 135 ILAIPeaiGFVMVPFEYNGEQYRTCMLNATTKFMNFYVDAKdWWLFGFYFCVPLACTAIFYTLMtceMLNRRKGSLRIAL 214
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 148 SKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTY-------ANSCANPILYAFLSD 220
Cdd:cd15975 215 SEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNENDPRRCELLSFLLVMDYisinlatMNSCINPIALYFVSK 294

                ....*.
gi 12652991 221 NFKKSF 226
Cdd:cd15975 295 KFKNCF 300
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
32-226 3.54e-06

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 47.16  E-value: 3.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILPImiyAGLRSNQWGRSSCTINWPGESGAWYTG 110
Cdd:cd15360  94 SVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVaLLPI---FGISSYMKVSICLPMDIESPLSQAYII 170
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 111 FIIYTFILGFLvpltIICLCYLFIIIKVKSSGIrvgsSKRKKSEKKVTRMVSIVVAVFIfCWLPFYIFNVSSvSMAISPT 190
Cdd:cd15360 171 FILVLNVLAFL----IICACYIKIYLTVRNPNF----VSSNSDTKIAKRMAVLIFTDFL-CMAPISFFAISA-SLKVPLI 240
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 12652991 191 PALKGmfDFVVVLTYA-NSCANPILYAFLSDNFKKSF 226
Cdd:cd15360 241 TVSKS--KILLVLFYPiNSCANPFLYAIFTKTFRRDF 275
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
13-223 3.55e-06

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 47.12  E-value: 3.55e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  13 FGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRpRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWG 92
Cdd:cd15076  68 FGRTVCALEAFVGSLAGLVTGWSLAFLAFERYIVICKPFGNFRFGS-KHALGAVVATWIIGIGVSLPPFFGWSRYIPEGL 146
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  93 RSSCTINWPGES----GAWYTGFIiytFILGFLVPLTIICLCYLFIIIKVKS-SGIRVGSSKRKKSEKKVTRMVSIVVAV 167
Cdd:cd15076 147 QCSCGPDWYTVGtkyrSEYYTWFL---FIFCFIVPLSIIIFSYSQLLGALRAvAAQQQESASTQKAEREVSRMVVVMVGS 223
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 168 FIFCWLPFYIFnvsSVSMAISPTPALKGMFDFVVVLTYANSCA-NPILYAFLSDNFK 223
Cdd:cd15076 224 FCLCYVPYAAL---AMYMVNNRDHGLDLRLVTIPAFFSKSSCVyNPIIYCFMNKQFR 277
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
8-223 3.95e-06

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 46.97  E-value: 3.95e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   8 LVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAkWRrprTAKMITMAVWGVSLLvilpimiYAGLR 87
Cdd:cd15072  62 LRRWPYGSEGCQAHGFQGFFTALASICSSAAIAWDRYHHYCTRSKLQ-WS---TAISLVLFVWLFSAF-------WAAMP 130
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  88 SNQWG-------RSSCTINWP-GESGawYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRvgsskrkksekkvTR 159
Cdd:cd15072 131 LLGWGeydyeplGTCCTLDYSkGDRN--YVSYLFTMAFFNFILPLFILLTSYSSIEQKLKKEGHL-------------RF 195
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12652991 160 MVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTyanSCA-NPILYAFLSDNFK 223
Cdd:cd15072 196 NTGLPLLTLLICWGPYAILALYAAITDVTSISPKLRMVPALLAKT---SPTiNAILYALGNENYR 257
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
32-225 4.31e-06

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 47.08  E-value: 4.31e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILPIMIYAGLRsnqwGRSSCTINWPgesgawYTG 110
Cdd:cd15100  83 SVCSLLAITVDRYLSLYNALTYYSERTLTFTYVMLALLWTLALGLgLLPVLGWNCLR----EGSSCSVVRP------LTK 152
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 111 FIIYTFILGFLVPLTIICLCYLFI--IIKVKSSGIRVGSSKRKKSEKKVTR----MVSIVVAVFIFCWLPFYIFNVssvs 184
Cdd:cd15100 153 NHLAVLAVAFLLVFALMLQLYAQIcrIVLRHAHQIALQRHFLAPSHYVATRkgvsTLALILGTFAACWIPFAVYCL---- 228
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 12652991 185 MAISPTPALKgMFDFVVVLTYaNSCANPILYAFLSDNFKKS 225
Cdd:cd15100 229 LGDGSSPALY-TYATLLPATY-NSMINPIIYAFRNQDIQKV 267
7tmA_MrgprB cd15107
mas-related G protein-coupled receptor subtype B, member of the class A family of ...
36-217 6.99e-06

mas-related G protein-coupled receptor subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320235  Cd Length: 276  Bit Score: 46.24  E-value: 6.99e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  36 LTVMSIDRYLAVVHPIksakW---RRPR-TAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCtinwpgesgaWYTGF 111
Cdd:cd15107  89 ITAISIERCLSVMWPI----WyhcQRPRhTSAVICTLLWVLSLLLSLLEGKGCGFLFSTYDYYWC----------WTLDL 154
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 112 IIYTFILGFLVPLTIICLCYLFIIIkvkssgirvgsskRKKSEKKVTRM-VSIV--VAVFIFCWLPFYIFNVSSVSMAIS 188
Cdd:cd15107 155 ITTAWLIVLFVVLSGSSLALLVRIF-------------CGSHRIPVTRLyVTIAltVLVFLIFGLPFGIYWFLLKWIEEF 221
                       170       180
                ....*....|....*....|....*....
gi 12652991 189 PTPALKGMFDFVVVLTYANSCANPILYAF 217
Cdd:cd15107 222 YIVPCCGFYEVILFLSCVNSCANPIIYFL 250
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
32-226 7.80e-06

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 46.17  E-value: 7.80e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSL-LVILPIMIYAGLRSnqwgRSSCTINWPGESGAWYTG 110
Cdd:cd15961  83 SVCSLLAITVDRYLSLYYALTYNSERTVTFTYVMLVLLWGASIcLGLLPVMGWNCLAD----ESTCSVVRPLTKNNAAIL 158
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 111 FIIYTFILGFLVPLTI-ICLcylfiIIKVKSSGIRVGSSKRKKSEKKVTR----MVSIVVAVFIFCWLPFYIFNVssvsM 185
Cdd:cd15961 159 SVSFLLMFALMLQLYIqICK-----IVMRHAHQIALQHHFLATSHYVTTRkgvsTLAIILGTFAACWMPFTLYSL----I 229
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 12652991 186 AISPTPALKgMFDFVVVLTYaNSCANPILYAFLSDNFKKSF 226
Cdd:cd15961 230 ADYTYPSIY-TYATLLPATY-NSIINPVIYAFRNQEIQKAL 268
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
32-226 1.31e-05

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 45.57  E-value: 1.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVhpiKSAKWRRPRTAKMITM--AVWGVSLLVI-LPIMIYAGLRSNQwgrsSCTINWPgesgaWY 108
Cdd:cd15347  86 SVFSLLAIAIERHVAIT---KVKLYGSDKNCRMVLLigACWVISIVLGgLPILGWNCIGNLE----DCSTVLP-----LY 153
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 109 TGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTrmvsIVVAVFIFCWLPFYIFNVSSVSMAIS 188
Cdd:cd15347 154 SKHYILFVVTIFSIILLSIVILYVRIYCIVRSSHAEMAAPQTLALLKTVT----IVLGVFIVCWLPAFIILLLDTSCKVK 229
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 12652991 189 PTPALKGMFDFVVVLTYaNSCANPILYAFLSDNFKKSF 226
Cdd:cd15347 230 SCPILYKADYFFSVATL-NSALNPVIYTLRSKDMRKEF 266
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
11-225 1.34e-05

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 45.62  E-value: 1.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHP-IKSAKWRRPRTAKMITMAvWGVSLLVILPImIYAGLRSN 89
Cdd:cd15316  66 WYFGESFCTFHTCCDVSFCYASLFHLCFISVDRYIAVTDPlVYPTKFTVSVSGICISVS-WIFSLTYSFSV-FYTGVNDD 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKK------------- 156
Cdd:cd15316 144 GLEELVNALNCVGGCQIILNQNWVLVDFLLFFIPTFAMIILYGKIFLVAKQQARKIEMTSSKAESSSesykdrvarrerk 223
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 157 VTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISpTPALkgMFDFVVVLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15316 224 AAKTLGITVIAFLVSWLPYLIDVLIDAFMNFI-TPPY--IYEICCWCAYYNSAMNPLIYALFYPWFRKA 289
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
32-226 2.01e-05

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 44.87  E-value: 2.01e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHpIKSAKWRRPRTAKMITMAVWGVSLLVI-LPIMIYAGLRSnqwgRSSCTINWPgesgAWYTG 110
Cdd:cd15346  86 SVFSLLAIAIERYITMLK-MKLHNGSNSFRSFLLISACWVISLILGgLPIMGWNCISA----LSSCSTVLP----LYHKH 156
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 111 FIIY-TFILGFLVPLTIICLCYLFIIIKVKSSGIRV-----GSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVS 184
Cdd:cd15346 157 YILFcTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFrknirKASRSSEKSMALLKTVIIVLSVFIACWAPLFILLLLDVG 236
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 12652991 185 MAISPTPALKGMfDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15346 237 CKVKTCSILFKA-EYFLVLAVLNSATNPIIYTLTNKEMRRAF 277
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
31-226 2.21e-05

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 44.84  E-value: 2.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  31 TSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMI----YAGLRSNQWGRSS---CTINWPGE 103
Cdd:cd15071  84 SSILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMFgwnnLNAVERAWAANSSmgeLVIKCQFE 163
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 104 SGAWYTGFIIYTFILGFLVPLTIICLCYL--FIIIKV----KSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYI 177
Cdd:cd15071 164 TVISMEYMVYFNFFVWVLPPLLLMLLIYLevFYLIRKqlnkKVSSSSSDPQKYYGKELKIAKSLALILFLFALSWLPLHI 243
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 12652991 178 FNVSSVSMAISPTPALkgMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15071 244 LNCITLFCPSCKKPMI--LTYIAIFLTHGNSAMNPIVYAFRIKKFRTTF 290
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
10-223 2.40e-05

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 44.81  E-value: 2.40e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIyagLRSN 89
Cdd:cd15166  64 EWPFGDYFCRILGALTVFYPSIALWLLAFISADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLASTFPLLF---LYED 140
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCTINWPGESGAWYTGFIIYTF---ILGFLVPLTIICLCYLFIII------------KVKSSGIRVgsskrkkse 154
Cdd:cd15166 141 PDKASNFTTCLKMLDIIHLKEVNVLNFtrlIFFFLIPLFIMIGCYLVIIHnlvhgrtsklkpKVKEKSIRI--------- 211
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12652991 155 kkvtrMVSIVVAVFIfCWLPFYIFNVssVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFK 223
Cdd:cd15166 212 -----IITLIVQVLV-CFVPFHICFA--FLMLQNGDNSYNPWAAFTTFLMNLSTCLDVILYYIVSKQFQ 272
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
32-226 2.42e-05

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 44.85  E-value: 2.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILPImiyAGLrSNQWGRSSCtinWPGESGAWYTG 110
Cdd:cd15359  94 SVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIaVLPL---VGV-SNYMKVSIC---LPMDIETLLSQ 166
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 111 FIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIrvgssKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAisPT 190
Cdd:cd15359 167 AYILLILVLNVIAFLVICACYIKIYLAVQNPEL-----VAKNKDTKIAKRMAILIFTDFTCMAPISFFAISAAFKV--PL 239
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 12652991 191 PALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15359 240 ITVTNSKILLVLFYPINSCANPFLYAIFTKAFRRDF 275
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
32-225 2.43e-05

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 44.82  E-value: 2.43e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHpiksAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESgAWYTGF 111
Cdd:cd15078  87 SIMTLTVLAYERYIRVVH----AKVVNFSWSWRAITYIWLYSLAWTGAPLLGWNRYTLEVHGLGCSFDWKSKD-PNDTSF 161
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 112 IIYTFILGFLVPLTIICLCYLFIIIKVK-----SSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFN---VSSV 183
Cdd:cd15078 162 VLLFFLGCLVVPLGIMAYCYGHILYEIRmlrsvEDLQTFQVIKILKYEKKVAKMCLLMISTFLICWMPYAVVSllvTSGY 241
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 12652991 184 SMAISPTPALKGMFdfvvvLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15078 242 SKLVTPTIAIIPSL-----FAKSSTAYNPVIYIFMIRKFRQC 278
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
32-225 5.63e-05

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 43.67  E-value: 5.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPiKSAKWRRPRTAKMITMAV-WGVSLLV-ILPIMIYAGLRSNqwgrSSCTINWPGESGAWYT 109
Cdd:cd15341  87 SLGSLLLMAFDRYVCIYYP-SEYKALVTRKRALVALAVmWVLTALIaYLPLMGWNCCPLN----SPCSELFPLIPNDYLL 161
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 110 GFIIYTFILgflvpLTIICLCYLFIIIKV--------KSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVS 181
Cdd:cd15341 162 SWLLLVAIL-----LSGIIYTYGHVLWKAhkhvvymeKHQDQQGPGNARMRLDVRLAKTLGLVLAVLLICWSPVLALMMH 236
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 12652991 182 SvsMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKS 225
Cdd:cd15341 237 S--LFTSLSDHIKKAFAFCSTLCLVNSMVNPIIYALRSRELRSS 278
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
32-226 6.45e-05

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 43.23  E-value: 6.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIksakwrrpRTAKMITMAVWGVSLLVIlpimiyaglrsnqWgrSSCtinwpGESGAWYTGF 111
Cdd:cd15350  93 SIFSILAIAADRYITIFHAL--------RYHNIMTMRRTLVILAII-------------W--TFC-----GGSGILMILF 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 112 -----IIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRM-----VSIVVAVFIFCWLPFYIFNVS 181
Cdd:cd15350 145 fhfvaTVICFTVLFFLMLVLILCLYVHMFLLARSHARKIASLPNHHAQHQRSNMrgaitLTILLGVFVCCWAPFVLHLLL 224
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 12652991 182 SVSMAISPTPA-LKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15350 225 MMFCPMNPYCAcYRSLFQVNGTLIMSHAVIDPAIYAFRSPELRNTF 270
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
31-223 9.24e-05

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 42.97  E-value: 9.24e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  31 TSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYaglrSNQWG---RSSCTIN-WPGESGA 106
Cdd:cd15081  98 TGLWSLTIISWERWVVVCKPFGNIKFDGKLAIVGIIFSWVWSAVWCAPPIFGW----SRYWPhglKTSCGPDvFSGSSDP 173
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 107 WYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKS-SGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLP---FYIFNVSS 182
Cdd:cd15081 174 GVQSYMIVLMITCCIIPLAIIILCYLQVWLAIRAvAQQQKESESTQKAEKEVSRMVVVMIFAYCFCWGPytfFACFAAAN 253
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 12652991 183 VSMAISP-TPALKGMFdfvvvlTYANSCANPILYAFLSDNFK 223
Cdd:cd15081 254 PGYAFHPlAAALPAYF------AKSATIYNPIIYVFMNRQFR 289
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
32-226 1.49e-04

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 42.09  E-value: 1.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAglrsnqwgrssctinwpgesgawYTGF 111
Cdd:cd15103  93 SICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFIIYS-----------------------DSVP 149
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 112 IIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRM-----VSIVVAVFIFCWLPFYIFNVSSVSMA 186
Cdd:cd15103 150 VIICLISMFFAMLVLMASLYVHMFLLARSHVKKIAALPGQRSTRQRANMkgavtLTILLGVFIFCWAPFFLHLTLMISCP 229
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 12652991 187 ISPTPA-LKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15103 230 SNPYCAcYMSHFNVYLILIMCNSVIDPLIYAFRSQELRKTF 270
7tmA_MrgprA cd15105
mas-related G protein-coupled receptor subtype A, member of the class A family of ...
31-217 1.51e-04

mas-related G protein-coupled receptor subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320233  Cd Length: 276  Bit Score: 42.42  E-value: 1.51e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  31 TSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRssctinwpgESGAWYTG 110
Cdd:cd15105  84 TGLSMLSAISTERCLSVLCPIWYRCRRPEHTSTVMCAVIWVLSLLICILNRYFCGFLDTKYEN---------DSVCLASN 154
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 111 FIIYTFiLGFLVplTIICLCYLFIIIKVKSsgirvGSSKRKKSEKKVTRMVSIVVavFIFCWLPFYIFNVSSVSMAISPT 190
Cdd:cd15105 155 FFTAAY-LMFLF--VVLCLSSLALLARLFC-----GAGQMKLTRLYVTIMLTVLV--FLLCGLPFGIYWFLLFWIKDDFH 224
                       170       180
                ....*....|....*....|....*..
gi 12652991 191 PALKGMFDFVVVLTYANSCANPILYAF 217
Cdd:cd15105 225 VLDYGLYLASVVLTAVNSCANPIIYFF 251
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
32-226 2.52e-04

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 41.42  E-value: 2.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLV-ILPIMIYAGLRSnqwgRSSCTINWPGESGAWYTG 110
Cdd:cd15960  83 SVCSLLAITVDRYLSLYNALTYHTERTLTFTYGLLALLWLTCIGIgLLPAMGWNCLRA----PASCSVLRPVTKNNAAVL 158
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 111 FIIYTFILGFLVPLtiiclcYLFI--IIKVKSSGIRVGSSKRKKSEKKVTR----MVSIVVAVFIFCWLPFYIFnvssvs 184
Cdd:cd15960 159 AVSFLLLFALMMQL------YLQIcrIAFRHAQQIAVQHQFVNFCLASSTRkgvsTLSLILATFAFCWVPFAVY------ 226
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 12652991 185 mAISPTPALKGMFDFVVVLTYA-NSCANPILYAFLSDNFKKSF 226
Cdd:cd15960 227 -SMVADSSYPMIYTYYLVLPAAcNSVINPIIYAFRNPDIQKSL 268
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
32-225 3.64e-04

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 41.07  E-value: 3.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSL-LVILPIMIYAGLRSnqwgRSSCTINWPGESGAWYTG 110
Cdd:cd15962  83 SVSSLLAITVDRYLSLYNALTYYSEKTVLGVHLMLAATWGVSLcLGLLPVLGWNCLEE----RASCSIVRPLTKSNVTLL 158
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 111 FIIYTFILGFLVPLTI-ICLcylfiIIKVKSSGIRVGSSKRKKSEKKVTR----MVSIVVAVFIFCWLPFYIFNVSsvsm 185
Cdd:cd15962 159 SASFFFIFILMLHLYIkICK-----IVCRHAHQIALQQHFLTASHYVATKkgvsTLAIILGTFGASWLPFAIYCVV---- 229
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 12652991 186 aisptpalkGMFDFVVVLTYA-------NSCANPILYAFLSDNFKKS 225
Cdd:cd15962 230 ---------GDHEYPAVYTYAtllpatyNSMINPIIYAYRNQEIQRS 267
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
11-219 4.14e-04

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 40.88  E-value: 4.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICRVVmtvdGINQFTSIFC----LTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSL----LVIL--PI 80
Cdd:cd14983  66 WTLPAVLCPLY----NLAHFSTLYAstcfLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWALVIfhvtLVFIleTS 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYL-FIIIKVKSSgirvgssKRKKSEKKVTR 159
Cdd:cd14983 142 GGTLDINTPVGNSSTCYENFTPEQLALLAPVRLELSLVLFFLPLAITAFCYVrCIRILVRSR-------LHERRKRRAVR 214
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 160 MVSIVVAVFIFCWLPFYIFNVssVSMAISPTPALKGMfdfVVVLTYANSCANPILYAFLS 219
Cdd:cd14983 215 VAVSTLLTFVVCFGPYNISHV--VGFVRHESVWWRKL---ALLTSTCNAFLDPLIFYFLS 269
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
161-226 4.79e-04

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 40.66  E-value: 4.79e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 161 VSIVVAVFIFCWLPFYIFNVSSVSMAISP-TPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15353 203 LTILLGVFVVCWAPFFLHLIFYISCPRNPyCVCFMSHFNMYLILIMCNSVIDPLIYAFRSQELRKTF 269
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
1-224 5.22e-04

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 40.69  E-value: 5.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   1 FLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPI 80
Cdd:cd15214  55 FVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLPP 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  81 MI-YAGLRSNQWgRSSCTINWPGESGawYTGFIIytfILGFLVPLTIICLCYLFIIIKVKSSGIRVgsskrkksekKVTR 159
Cdd:cd15214 135 LFgWSSLEFDRF-KWMCVAAWHKEAG--YTAFWQ---VWCALLPFVVMLVCYGFIFRVARANQCKA----------FITI 198
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12652991 160 MVsiVVAVFIFCWLPFYIFNVSSVSMAI-SPTPALKGMfdfVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15214 199 LV--VLGAFVTTWGPYMVVISTEALWGKnSVSPQLETL---ATWLSFTSAVCHPLIYGLWNKTVRK 259
7tmA_GPR3 cd15963
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G ...
32-224 5.27e-04

G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320629 [Multi-domain]  Cd Length: 268  Bit Score: 40.64  E-value: 5.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSL-LVILPIMIYAGLRsnqwGRSSCTINWPGESGAWYTG 110
Cdd:cd15963  83 SVSSLLAITIDRYLSLYNALTYYSERTVTRTYIMLILTWGASLcLGLLPVVGWNCLK----DPSTCSVVKPLTKNHLVIL 158
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 111 FIIYTFILGFLVPL-TIICLcylfiIIKVKSSGIRVGSSKRKKSEKKVTR----MVSIVVAVFIFCWLPFYIFNVssvsM 185
Cdd:cd15963 159 SISFFMVFALMLQLyAQICR-----IVCRHAHQIALQRHFLPTSHYVTTRkgiaTLAVILGTFASCWLPFAVYCL----L 229
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 12652991 186 AISPTPALkgmFDFVVVL--TYaNSCANPILYAFLSDNFKK 224
Cdd:cd15963 230 GDYTYPAL---YTYATLLpaTY-NSMINPIIYAFRNQEIQK 266
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
18-224 5.34e-04

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 40.62  E-value: 5.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  18 CRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKmITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCT 97
Cdd:cd15965  80 CQLVGSLAILSTEVSVLLLTYLTLEKYICIVYPFRCLTPGKCRTIT-ILILIWIIGFIIAFIPLSNKEFFRNYYGTNGVC 158
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  98 INWPGESGAwYTGFIIYTFILGF---LVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSE-KKVTRMVSIVVAVFIFCWL 173
Cdd:cd15965 159 FPLHSEQPE-STGAQIYSVVIFLglnLAAFIIIVFSYGSMFYSIHQTAIMATEISNHIKKeMTLAKRFFFIVFTDALCWI 237
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 12652991 174 PFYIFNVSSVSMAISPTPALKGMFDFVVVLtyaNSCANPILYAFLSDNFKK 224
Cdd:cd15965 238 PIFILKLLSLLQVEIPGTISSWVVIFILPI---NSALNPILYTLTTRPFKE 285
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
10-217 9.12e-04

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 39.78  E-value: 9.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  10 HWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSN 89
Cdd:cd14994  64 TWKFGMPLCKMVSAMIHIHMHLTFLFYVIILVIRYLIFFQRKDKMEFYRKLHAVAASAVVWVLVLLIVVPVFVKEYGSSS 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  90 QWGRSSCtINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVkssgIRVGSSKRKKSEKKVTRMVS-IVVAVF 168
Cdd:cd14994 144 SYNSDQC-FKFHKELEVHYVKVLNYIIICIVLIVTLALLGFQVFILGHV----YRKLRASLLSHQEFWAQMKSlFFIVVI 218
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 12652991 169 IFCWLPFYIFNVSSVSMaISPTPALKGMFDFVVVLTyANSCANPILYAF 217
Cdd:cd14994 219 IVCFVPYNLFRIYYLSQ-VIQNEKLDPYNEIFLAVT-ALSCLDLLTFVG 265
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
161-226 1.14e-03

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 39.49  E-value: 1.14e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12652991 161 VSIVVAVFIFCWLPFYIFNVSSVSMAISPTPA-LKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15352 206 ITILLGVFIVCWAPFFLHLILIISCPHNPYCLcYTSHFNTYLVLIMCNSVIDPLIYAFRSLEMRKTF 272
7tmA_GPR142 cd15129
G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G ...
4-223 1.18e-03

G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR142, a vertebrate orphan receptor, is very closely related to GPR139, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating enhancement of glucose-stimulated insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320257 [Multi-domain]  Cd Length: 270  Bit Score: 39.37  E-value: 1.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991   4 MQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIY 83
Cdd:cd15129  61 LQTAILAREVPHALIHTVSVLEFAANHASIWITVLLTVDRYVALCHPLRYRAVSYPERTRRIIAAVFVAALATGIPFYWW 140
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  84 aglrSNQWgRSSCTINWPGESGAWYTGFIIYtfilgfLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEkkvTRMVSI 163
Cdd:cd15129 141 ----SDMW-RDSHPPTTLDKVLKWTHCFIIY------FIPCTIFLVTNSVIIHKLRRRKGRSGPQRRSGKT---TAILLA 206
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12652991 164 VVAVFIFCWLP-----FYIFNVSSVSMAISPTPAlkgmFDFVVVLTYANSCANPILYAFLSDNFK 223
Cdd:cd15129 207 ITTVFAVLWAPrtvviIYHLYVSSVNRDWRVHLA----LDLANMLAMLNTAVNFFLYCFVSKRFR 267
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
11-128 1.28e-03

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 39.41  E-value: 1.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  11 WPFGKAICR---VVMTVDGINQFtSIFCltVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVS-LLVILPIMIYaGL 86
Cdd:cd15142  68 WPGGQPLCEyfsFILLFFSLSGL-SIIC--AMSIERYLAINHAYFYNHYVDKRLAGLTLFAIYASNiLFCALPSMGL-GK 143
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 12652991  87 RSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIIC 128
Cdd:cd15142 144 SKLQYPKTWCFIDWRTNVSVHAAYSYMYAGFSSLLILVTVLC 185
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
14-224 1.32e-03

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 39.43  E-value: 1.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  14 GKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAV-WGVSLLVILP-IMIYAGLRSNQW 91
Cdd:cd15171  67 GNPTCKVLVALSSVGLHSEALFNVLLTVQASRVFFHGRLASSARRVAPCGIIASVLaWLTAFLVTLPeFVFYKPQMDSQK 146
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  92 GRSSCTINW--PGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRvgsskrkkseKKVTRMVSIVVAVFI 169
Cdd:cd15171 147 SKCAFSRPHflPAEETFWKYFLTLKMNIVVLVFPLLVFIICCVQLRKTQRFRERQ----------RDLSKLVFAIMVVFL 216
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12652991 170 FCWLPFYI-FNVSSVSMAIS-----PTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKK 224
Cdd:cd15171 217 LMWAPYNIaLFLSAFKEHFSlrdckSSYHLDASVQVTKLIATTHCCVNPLLYALLDPAFRR 277
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
31-138 3.89e-03

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 37.85  E-value: 3.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  31 TSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVIL-PIMIYAGL---RSNQWG----------RSSC 96
Cdd:cd15912  86 TEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILpPTILVFQLpfcGPNVINhffcdsgpllKLSC 165
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 12652991  97 TINWPGESgawyTGFIIYTFILgfLVPLTIICLCYLFIIIKV 138
Cdd:cd15912 166 SDTRLIEL----LDFILASVVL--LGSLLLTIVSYIYIISTI 201
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
36-75 5.23e-03

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 37.62  E-value: 5.23e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 12652991  36 LTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLL 75
Cdd:cd15232  91 LTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGML 130
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
28-226 5.45e-03

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 37.61  E-value: 5.45e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  28 NQFTSIFCLTV---------MSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGlrsnqwgrsscti 98
Cdd:cd15354  80 NVFDSLICISVvasmcsllaIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCTGCGIIFILYSE------------- 146
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  99 nwpgesgawyTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRM-----VSIVVAVFIFCWL 173
Cdd:cd15354 147 ----------STYVIICLITMFFAMLFLMVSLYIHMFLLARTHVKRIAALPGYNSVRQRTSMkgavtLTILLGIFIVCWA 216
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 12652991 174 PFYIFNVSSVSMAISP-TPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15354 217 PFFLHLILMISCPQNLyCVCFMSHFNMYLILIMCNSVIDPLIYAFRSQEMRKTF 270
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
32-226 5.73e-03

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 37.58  E-value: 5.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  32 SIFCLTVMSIDRYLAVVHPIkSAKWRRPRTAKMITMAV-WGVSLLV-ILPIMIYAGLRSNqwgrSSCTINWPGESGAWYT 109
Cdd:cd15340  87 SVGSLFLTAIDRYISIHRPL-AYKRIVTRTKAVIAFCVmWTIAIVIaVLPLLGWNCKKLN----SVCSDIFPLIDETYLM 161
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991 110 GFIIYTFILgflvpLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVT---------------------RMVSIVVAVF 168
Cdd:cd15340 162 FWIGVTSVL-----LLFIVYAYMYILWKAHHHAVRMLQRGTQKSIIVYTsedgkvqttrpdqtrmdirlaKTLVLILVVL 236
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 12652991 169 IFCWLPFYIFNVSSVSMAISPTpaLKGMFDFVVVLTYANSCANPILYAFLSDNFKKSF 226
Cdd:cd15340 237 IICWGPLLAIMVYDVFGKMNKL--IKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAF 292
7tmA_PGE2_EP3 cd15146
prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G ...
20-188 8.37e-03

prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP3, also called prostanoid EP3 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Stimulation of the EP3 receptor by PGE2 preferentially couples to G(i) protein. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels, which subsequently produces smooth muscle contraction. Knockout mice studies suggest that the EP3 receptor may act as a systemic vasopressor. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320274 [Multi-domain]  Cd Length: 308  Bit Score: 37.16  E-value: 8.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  20 VVMTVDGInqfTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVW-GVSLLVILPIMiYAGLRSNQWGRSSCTI 98
Cdd:cd15146  87 LCMTVFGL---CPLFIASAMAIERALAIRAPHWYSSHMKTRVTKAVLLGIWlAVLAFALLPIA-GVGQYTLQWPGTWCFI 162
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  99 NwpGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIII------KVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIfCW 172
Cdd:cd15146 163 S--TGDGEPGNNFFASTFASLGLFSLCVTFSCNLATIRalvsrcKTKAGASVSSKQWERITTETLIQLLGIMCVLSA-CW 239
                       170
                ....*....|....*.
gi 12652991 173 LPFYIFNVSSVSMAIS 188
Cdd:cd15146 240 SPLLVLMLKMISNHTS 255
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
31-144 9.97e-03

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 36.69  E-value: 9.97e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12652991  31 TSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVIL-PIMIYAGL---RSNQ----------WGRSSC 96
Cdd:cd13954  86 TECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLiHTVLISQLpfcGSNVinhffcdippLLKLSC 165
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 12652991  97 TINWPGEsgawYTGFIIYTFILgfLVPLTIICLCYLFI---IIKVKSSGIR 144
Cdd:cd13954 166 SDTSLNE----LVIFILAGFVG--LGSFLLTLVSYIYIistILKIPSAEGR 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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