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Conserved domains on  [gi|23273080|gb|AAH32875|]
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Pbx4 protein [Mus musculus]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10052840)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

Gene Ontology:  GO:0003677|GO:0006357|GO:0043565
PubMed:  1357790|26464018|21557080

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PBC super family cl04264
PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) ...
 1-36 5.65e-18

PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins.


The actual alignment was detected with superfamily member pfam03792:

Pssm-ID: 461052  Cd Length: 181  Bit Score: 77.42  E-value: 5.65e-18
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 23273080     1 MEHMVNTIQSKFSAIQRQLKQSTCEAVMTLRSRFLD 36
Cdd:pfam03792 146 IERMVSIISKKFNKIQEQLKQSTCEAVMILRSRFLD 181
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 38-98 1.65e-16

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 70.35  E-value: 1.65e-16
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23273080  38 RRKRRNFSKQATDVLNEYFyshLSNPYPSEETKEELARKGGITVSQVSNWFGNKRIRYKKN 98
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEF---EKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
 
Name Accession Description Interval E-value
PBC pfam03792
PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) ...
 1-36 5.65e-18

PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins.


Pssm-ID: 461052  Cd Length: 181  Bit Score: 77.42  E-value: 5.65e-18
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 23273080     1 MEHMVNTIQSKFSAIQRQLKQSTCEAVMTLRSRFLD 36
Cdd:pfam03792 146 IERMVSIISKKFNKIQEQLKQSTCEAVMILRSRFLD 181
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 38-98 1.65e-16

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 70.35  E-value: 1.65e-16
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23273080  38 RRKRRNFSKQATDVLNEYFyshLSNPYPSEETKEELARKGGITVSQVSNWFGNKRIRYKKN 98
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEF---EKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
Homeodomain pfam00046
Homeodomain;
38-97 3.83e-16

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 69.07  E-value: 3.83e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273080    38 RRKRRNFSKQATDVLNEYFyshLSNPYPSEETKEELARKGGITVSQVSNWFGNKRIRYKK 97
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEF---QENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 38-96 6.33e-15

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 66.12  E-value: 6.33e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 23273080     38 RRKRRNFSKQATDVLNEYFyshLSNPYPSEETKEELARKGGITVSQVSNWFGNKRIRYK 96
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEF---QKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
36-133 5.22e-10

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 55.52  E-value: 5.22e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273080  36 DARRKRRNFSKQATDVLNEYFyshLSNPYPSEETKEELARKGGITVSQVSNWFGNKRIRYKKnTGKFQEEATMYTGKAST 115
Cdd:COG5576  50 PPKSKRRRTTDEQLMVLEREF---EINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKK-KRSGKVEQRPGEEEADL 125

                        90
                ....*....|....*...
gi 23273080 116 VTKARRPRGQSSCQSTPS 133
Cdd:COG5576 126 AKIGSLSTGQISIIETLE 143
 
Name Accession Description Interval E-value
PBC pfam03792
PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) ...
 1-36 5.65e-18

PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins.


Pssm-ID: 461052  Cd Length: 181  Bit Score: 77.42  E-value: 5.65e-18
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 23273080     1 MEHMVNTIQSKFSAIQRQLKQSTCEAVMTLRSRFLD 36
Cdd:pfam03792 146 IERMVSIISKKFNKIQEQLKQSTCEAVMILRSRFLD 181
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 38-98 1.65e-16

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 70.35  E-value: 1.65e-16
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23273080  38 RRKRRNFSKQATDVLNEYFyshLSNPYPSEETKEELARKGGITVSQVSNWFGNKRIRYKKN 98
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEF---EKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
Homeodomain pfam00046
Homeodomain;
38-97 3.83e-16

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 69.07  E-value: 3.83e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273080    38 RRKRRNFSKQATDVLNEYFyshLSNPYPSEETKEELARKGGITVSQVSNWFGNKRIRYKK 97
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEF---QENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 56-94 5.98e-16

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 68.31  E-value: 5.98e-16
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 23273080    56 FYSHLSNPYPSEETKEELARKGGITVSQVSNWFGNKRIR 94
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 38-96 6.33e-15

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 66.12  E-value: 6.33e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 23273080     38 RRKRRNFSKQATDVLNEYFyshLSNPYPSEETKEELARKGGITVSQVSNWFGNKRIRYK 96
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEF---QKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
36-133 5.22e-10

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 55.52  E-value: 5.22e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273080  36 DARRKRRNFSKQATDVLNEYFyshLSNPYPSEETKEELARKGGITVSQVSNWFGNKRIRYKKnTGKFQEEATMYTGKAST 115
Cdd:COG5576  50 PPKSKRRRTTDEQLMVLEREF---EINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKK-KRSGKVEQRPGEEEADL 125

                        90
                ....*....|....*...
gi 23273080 116 VTKARRPRGQSSCQSTPS 133
Cdd:COG5576 126 AKIGSLSTGQISIIETLE 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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