NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|21619971|gb|AAH33205|]
View 

Procollagen C-endopeptidase enhancer [Homo sapiens]

Protein Classification

CUB domain-containing protein( domain architecture ID 10035952)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NTR_PCOLCE cd03576
NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are ...
 313-437 2.70e-62

NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which have been suggested to possess inhibitory functions towards specific serine proteases but not towards metzincins, which are inhibited by the related TIMPs.


:

Pssm-ID: 239631  Cd Length: 124  Bit Score: 197.61  E-value: 2.70e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971 313 PDAPTCPKQCRRTGTLQSNFCASSLVVTATVKSMVREPGeGLAVTVSLIGAYKTGGLDLPSPPTGASLKFYVPCKQCPPM 392
Cdd:cd03576   1 PTAALCQQKCRRTGTLESNYCSSEFVITGTVISMTRGPG-SLHATVSIIKLYKEGRLAITQAGKTMSVKITVVCKQCPLL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 21619971 393 KKGVSYLLMGQVEENRGPVLPPESFVVLHRPNQDQILTNLSKRKC 437
Cdd:cd03576  80 RRGLNYILMGQVDEEGRGVIPPESFVMLYKTKHQKLLAALSNKKC 124
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 37-147 6.37e-41

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 141.78  E-value: 6.37e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971  37 CGGDVKGE-SGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTF 115
Cdd:cd00041   1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 21619971 116 RPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYS 147
Cdd:cd00041  81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 159-270 2.22e-40

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 140.24  E-value: 2.22e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971 159 CGGRL-EKAQGTLTTPNWPESdYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAvSDDSRRLGKFCG 237
Cdd:cd00041   1 CGGTLtASTSGTISSPNYPNN-YPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGP-STSSPLLGRFCG 78

                        90       100       110
                ....*....|....*....|....*....|...
gi 21619971 238 DAVPGSISSEGNELLVQFVSDLSVTADGFSASY 270
Cdd:cd00041  79 STLPPPIISSGNSLTVRFRSDSSVTGRGFKATY 111
 
Name Accession Description Interval E-value
NTR_PCOLCE cd03576
NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are ...
 313-437 2.70e-62

NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which have been suggested to possess inhibitory functions towards specific serine proteases but not towards metzincins, which are inhibited by the related TIMPs.


Pssm-ID: 239631  Cd Length: 124  Bit Score: 197.61  E-value: 2.70e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971 313 PDAPTCPKQCRRTGTLQSNFCASSLVVTATVKSMVREPGeGLAVTVSLIGAYKTGGLDLPSPPTGASLKFYVPCKQCPPM 392
Cdd:cd03576   1 PTAALCQQKCRRTGTLESNYCSSEFVITGTVISMTRGPG-SLHATVSIIKLYKEGRLAITQAGKTMSVKITVVCKQCPLL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 21619971 393 KKGVSYLLMGQVEENRGPVLPPESFVVLHRPNQDQILTNLSKRKC 437
Cdd:cd03576  80 RRGLNYILMGQVDEEGRGVIPPESFVMLYKTKHQKLLAALSNKKC 124
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 37-147 6.37e-41

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 141.78  E-value: 6.37e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971  37 CGGDVKGE-SGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTF 115
Cdd:cd00041   1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 21619971 116 RPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYS 147
Cdd:cd00041  81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 159-270 2.22e-40

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 140.24  E-value: 2.22e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971 159 CGGRL-EKAQGTLTTPNWPESdYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAvSDDSRRLGKFCG 237
Cdd:cd00041   1 CGGTLtASTSGTISSPNYPNN-YPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGP-STSSPLLGRFCG 78

                        90       100       110
                ....*....|....*....|....*....|...
gi 21619971 238 DAVPGSISSEGNELLVQFVSDLSVTADGFSASY 270
Cdd:cd00041  79 STLPPPIISSGNSLTVRFRSDSSVTGRGFKATY 111
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 168-270 1.78e-38

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 134.83  E-value: 1.78e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971    168 GTLTTPNWPESdYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAvSDDSRRLGKFCGDAVPGS-ISS 246
Cdd:smart00042   1 GTITSPNYPQS-YPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGP-SASSPLLGRFCGSEAPPPvISS 78

                           90       100
                   ....*....|....*....|....
gi 21619971    247 EGNELLVQFVSDLSVTADGFSASY 270
Cdd:smart00042  79 SSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
37-146 2.34e-38

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 134.73  E-value: 2.34e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971    37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFR 116
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 21619971   117 PAPLVAPGNQVTLRMTTDEGTGGRGFLLWY 146
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 46-146 1.34e-36

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 129.82  E-value: 1.34e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971     46 GYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVA-PG 124
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISsSS 80

                           90       100
                   ....*....|....*....|..
gi 21619971    125 NQVTLRMTTDEGTGGRGFLLWY 146
Cdd:smart00042  81 NSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
159-270 9.71e-35

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 125.10  E-value: 9.71e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971   159 CGGRLEKAQGTLTTPNWPeSDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGaVSDDSRRLGKFCGD 238
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYP-NPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDG-PSASSPLLGRFCGS 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 21619971   239 AVPGSISSEGNELLVQFVSDLSVTADGFSASY 270
Cdd:pfam00431  79 GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
NTR pfam01759
UNC-6/NTR/C345C module; Sequence similarity between netrin UNC-6 and C345C complement protein ...
 330-434 5.71e-17

UNC-6/NTR/C345C module; Sequence similarity between netrin UNC-6 and C345C complement protein family members, and hence the existence of the UNC-6 module, was first reported in. Subsequently, many additional members of the family were identified on the basis of sequence similarity between the C-terminal domains of netrins, complement proteins C3, C4, C5, secreted frizzled-related proteins, and type I pro-collagen C-proteinase enhancer proteins (PCOLCEs), which are homologous with the N-terminal domains of tissue inhibitors of metalloproteinases (TIMPs). The TIMPs are classified as a separate family in Pfam (pfam00965). This expanded domain family has been named as the NTR module.


Pssm-ID: 396359  Cd Length: 106  Bit Score: 76.23  E-value: 5.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971   330 SNFCA-SSLVVTATVKSMVREpGEGLAVTVSLIGAYKTGGLDLPSPPTGASLKFYVpCKqCPPMKKGVSYLLMGQVEENR 408
Cdd:pfam01759   1 KKACKgSDYVYKVKVLSVEEE-GSFDKYTVKVKEVLKEGTDKIQRGKVRLFLKRGD-CR-CPQLRLGKEYLIMGKVGDLE 77

                          90       100
                  ....*....|....*....|....*....
gi 21619971   409 GP---VLPPESFVVLHRPNQDQILTNLSK 434
Cdd:pfam01759  78 GRgryVLDKNSWVEPWPTKWECKLRELQK 106
C345C smart00643
Netrin C-terminal Domain;
329-434 6.09e-13

Netrin C-terminal Domain;


Pssm-ID: 214759  Cd Length: 114  Bit Score: 65.08  E-value: 6.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971    329 QSNFCASSL--VVTATVKSMVREpGEGLAVTVSLIGAYKTGGLDLPSPPTGASLKFYVP-CKQCPPMKKGVSYLLMGQ-- 403
Cdd:smart00643   1 LEKACKSDVdyVYKVKVLSVEEE-GGFDKYTVKILEVIKSGTDELVRGKNKLRVFISRAsCRCPLLLKLGKSYLIMGKsg 79

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 21619971    404 ----VEENRGPVLPPESFVVLHRPNQDQILTNLSK 434
Cdd:smart00643  80 dlwdAKGRGQYVLGKNSWVEEWPTEEECRLRRLQK 114
 
Name Accession Description Interval E-value
NTR_PCOLCE cd03576
NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are ...
 313-437 2.70e-62

NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which have been suggested to possess inhibitory functions towards specific serine proteases but not towards metzincins, which are inhibited by the related TIMPs.


Pssm-ID: 239631  Cd Length: 124  Bit Score: 197.61  E-value: 2.70e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971 313 PDAPTCPKQCRRTGTLQSNFCASSLVVTATVKSMVREPGeGLAVTVSLIGAYKTGGLDLPSPPTGASLKFYVPCKQCPPM 392
Cdd:cd03576   1 PTAALCQQKCRRTGTLESNYCSSEFVITGTVISMTRGPG-SLHATVSIIKLYKEGRLAITQAGKTMSVKITVVCKQCPLL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 21619971 393 KKGVSYLLMGQVEENRGPVLPPESFVVLHRPNQDQILTNLSKRKC 437
Cdd:cd03576  80 RRGLNYILMGQVDEEGRGVIPPESFVMLYKTKHQKLLAALSNKKC 124
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 37-147 6.37e-41

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 141.78  E-value: 6.37e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971  37 CGGDVKGE-SGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTF 115
Cdd:cd00041   1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 21619971 116 RPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYS 147
Cdd:cd00041  81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 159-270 2.22e-40

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 140.24  E-value: 2.22e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971 159 CGGRL-EKAQGTLTTPNWPESdYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAvSDDSRRLGKFCG 237
Cdd:cd00041   1 CGGTLtASTSGTISSPNYPNN-YPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGP-STSSPLLGRFCG 78

                        90       100       110
                ....*....|....*....|....*....|...
gi 21619971 238 DAVPGSISSEGNELLVQFVSDLSVTADGFSASY 270
Cdd:cd00041  79 STLPPPIISSGNSLTVRFRSDSSVTGRGFKATY 111
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 168-270 1.78e-38

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 134.83  E-value: 1.78e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971    168 GTLTTPNWPESdYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAvSDDSRRLGKFCGDAVPGS-ISS 246
Cdd:smart00042   1 GTITSPNYPQS-YPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGP-SASSPLLGRFCGSEAPPPvISS 78

                           90       100
                   ....*....|....*....|....
gi 21619971    247 EGNELLVQFVSDLSVTADGFSASY 270
Cdd:smart00042  79 SSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
37-146 2.34e-38

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 134.73  E-value: 2.34e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971    37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFR 116
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 21619971   117 PAPLVAPGNQVTLRMTTDEGTGGRGFLLWY 146
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 46-146 1.34e-36

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 129.82  E-value: 1.34e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971     46 GYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVA-PG 124
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISsSS 80

                           90       100
                   ....*....|....*....|..
gi 21619971    125 NQVTLRMTTDEGTGGRGFLLWY 146
Cdd:smart00042  81 NSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
159-270 9.71e-35

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 125.10  E-value: 9.71e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971   159 CGGRLEKAQGTLTTPNWPeSDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGaVSDDSRRLGKFCGD 238
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYP-NPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDG-PSASSPLLGRFCGS 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 21619971   239 AVPGSISSEGNELLVQFVSDLSVTADGFSASY 270
Cdd:pfam00431  79 GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
NTR_like cd03523
NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in ...
 330-431 1.53e-26

NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the domain plays a role in controlling axon branching in neural development, while the common function of these modules in TIMPs appears to be binding to metzincins. A subset of this family is also known as the C345C domain because it occurs as a C-terminal domain in complement C3, C4 and C5. In C5, the domain interacts with various partners during the formation of the membrane attack complex.


Pssm-ID: 239600  Cd Length: 105  Bit Score: 102.93  E-value: 1.53e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971 330 SNFCASSLVVTATVKSMVREpGEGLAVTVSLIGAYKTGGLDLpsppTGASLKFYVPCKQC----PPMKKGVSYLLMGQVE 405
Cdd:cd03523   1 KAFCKSDYVVRAKIKEIKEE-NDDVKYEVKIIKIYKTGKAKA----DKADLRFYYTAPACcpchPILNPGREYLIMGKEE 75

                        90       100       110
                ....*....|....*....|....*....|
gi 21619971 406 ENRG-PVLPPESFVVLHRP---NQDQILTN 431
Cdd:cd03523  76 DSQGgLVLDPLSFVEPWSPlslRQDRRLRE 105
NTR pfam01759
UNC-6/NTR/C345C module; Sequence similarity between netrin UNC-6 and C345C complement protein ...
 330-434 5.71e-17

UNC-6/NTR/C345C module; Sequence similarity between netrin UNC-6 and C345C complement protein family members, and hence the existence of the UNC-6 module, was first reported in. Subsequently, many additional members of the family were identified on the basis of sequence similarity between the C-terminal domains of netrins, complement proteins C3, C4, C5, secreted frizzled-related proteins, and type I pro-collagen C-proteinase enhancer proteins (PCOLCEs), which are homologous with the N-terminal domains of tissue inhibitors of metalloproteinases (TIMPs). The TIMPs are classified as a separate family in Pfam (pfam00965). This expanded domain family has been named as the NTR module.


Pssm-ID: 396359  Cd Length: 106  Bit Score: 76.23  E-value: 5.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971   330 SNFCA-SSLVVTATVKSMVREpGEGLAVTVSLIGAYKTGGLDLPSPPTGASLKFYVpCKqCPPMKKGVSYLLMGQVEENR 408
Cdd:pfam01759   1 KKACKgSDYVYKVKVLSVEEE-GSFDKYTVKVKEVLKEGTDKIQRGKVRLFLKRGD-CR-CPQLRLGKEYLIMGKVGDLE 77

                          90       100
                  ....*....|....*....|....*....
gi 21619971   409 GP---VLPPESFVVLHRPNQDQILTNLSK 434
Cdd:pfam01759  78 GRgryVLDKNSWVEPWPTKWECKLRELQK 106
C345C smart00643
Netrin C-terminal Domain;
329-434 6.09e-13

Netrin C-terminal Domain;


Pssm-ID: 214759  Cd Length: 114  Bit Score: 65.08  E-value: 6.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971    329 QSNFCASSL--VVTATVKSMVREpGEGLAVTVSLIGAYKTGGLDLPSPPTGASLKFYVP-CKQCPPMKKGVSYLLMGQ-- 403
Cdd:smart00643   1 LEKACKSDVdyVYKVKVLSVEEE-GGFDKYTVKILEVIKSGTDELVRGKNKLRVFISRAsCRCPLLLKLGKSYLIMGKsg 79

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 21619971    404 ----VEENRGPVLPPESFVVLHRPNQDQILTNLSK 434
Cdd:smart00643  80 dlwdAKGRGQYVLGKNSWVEEWPTEEECRLRRLQK 114
NTR_Sfrp1_like cd03580
NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins ...
 316-408 2.47e-03

NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse functions and are thought to work in Wnt signaling indirectly, as modulators or antagonists by binding Wnt ligands, and directly, via the Wnt receptor, Frizzled. They participate in regulating the patterning along the anteroposterior axis in vertebrates. Human Sfrp1 has been found frequently to be downregulated in breast cancer and is associated with disease progression and poor prognosis.


Pssm-ID: 239635  Cd Length: 126  Bit Score: 38.04  E-value: 2.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971 316 PTCPkQCRRTG----TLQSNFCASSLVVTATVKSMVREPGEGLAVTVSLIGAYKTGGL---DLPSpptgasLKFYVP--- 385
Cdd:cd03580   2 KVCP-PCENEEesakTLLDNFCASDFALKVKIKEISYENGDRKVIGEKKKEILKQGPLkkkDLKK------LVLWLKnga 74

                        90       100
                ....*....|....*....|....*
gi 21619971 386 -CkQCPPM-KKGVSYLLMGQVEENR 408
Cdd:cd03580  75 nC-PCPQLdNLNGVYLVMGRKVDGK 98
NTR_netrin-1_like cd03579
NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called ...
 329-437 7.81e-03

NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration during neural development. These proteins may be chemoattractive to some neurons and chemorepellant for others. In the case of netrin-1, attraction and repulsion responses are mediated by the DCC and UNC-5 receptor families. The biological activities of C. elegans UNC-6, which may either attract or repel migrating cells or axons, are mediated by its different domains. The C-terminal NTR domain of UNC-6 has been shown to inhibit axon branching activity.


Pssm-ID: 239634  Cd Length: 115  Bit Score: 36.07  E-value: 7.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21619971 329 QSNFCASSLVVTATVKSMVREpGEGLAVTVSLIGAYKTGGLDLPSPPTGAslkfYVP-----CKqCPPMKKGVSYLLMGQ 403
Cdd:cd03579   1 LKKYCKKDYAVQAQVLSRETA-GEWAKFTVNVQTVYKRGTSRLRRGDQPL----WVPrkdlaCK-CPKLKVGKSYLLLGK 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 21619971 404 VEENRGP---VLPPESFVVLHRPNQDQILTNLSKR----KC 437
Cdd:cd03579  75 DEDSPERgglILDKRSLVIEWRDEWARRLRRFQRRerrgKC 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH