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Conserved domains on  [gi|71051436|gb|AAH34045|]
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FBXO21 protein [Homo sapiens]

Protein Classification

transglutaminase-like domain-containing protein( domain architecture ID 10596196)

transglutaminase-like domain-containing protein with C-terminal tetratricopeptide repeats

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
yccV TIGR02097
hemimethylated DNA binding domain; This model describes the small protein from E. coli YccV ...
409-506 7.53e-45

hemimethylated DNA binding domain; This model describes the small protein from E. coli YccV and its homologs in other Proteobacteria. YccV is now described as a hemimethylated DNA binding protein. The model also describes a domain in longer eukaryotic proteins.


:

Pssm-ID: 131152  Cd Length: 101  Bit Score: 153.30  E-value: 7.53e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051436   409 DVCYSIGLIMKHKRYGYNCVIYGWDPTCMMGHEWIRNMNVHSLPHgHHQPFYNVLVEDGSCR----YAAQENLEYNVEPQ 484
Cdd:TIGR02097   1 AAKFRIGQVVRHKLFGYRGVVIDVDPEYSNTEEWLDAIPVEIRPL-RDQPFYHVLAEDDEGLpyvaYVAEQNLLYDDSDE 79
                          90       100
                  ....*....|....*....|..
gi 71051436   485 EISHPDVGRYFSEFTGTHYIPN 506
Cdd:TIGR02097  80 PIEHPQVDELFDGFDEGLQKPR 101
Transglut_core2 pfam13369
Transglutaminase-like superfamily;
131-304 7.74e-44

Transglutaminase-like superfamily;


:

Pssm-ID: 463859  Cd Length: 155  Bit Score: 152.70  E-value: 7.74e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051436   131 KDIQAQIDSIVELVCKTLRGINSrhpslafkagessmimeielQSQVLDAMNYVLYDQLKFKGNRMDYYNALNLYMHQVL 210
Cdd:pfam13369   1 EAVLAELDALAAEVRARLPAELD--------------------PLEKLEALNRLLFGELGFKGNSEDYYDPDNSYLDQVL 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051436   211 IRRTGIPISMSLLYLTIARQLGVPLEPVNFPSHFLLRWCQGAEGatldifdYIYIDAFGKGKQLTVKECEYL----IGQH 286
Cdd:pfam13369  61 ERRRGIPISLGVIYLELARRLGLPLYGVNFPGHFLLRVDDTPDG-------EVYIDPFNGGEILSREDLEELlkgnLGPS 133
                         170       180
                  ....*....|....*....|
gi 71051436   287 V--TAALYGVVNVKKVLQRM 304
Cdd:pfam13369 134 AelDPEFLAPASNREILLRM 153
 
Name Accession Description Interval E-value
yccV TIGR02097
hemimethylated DNA binding domain; This model describes the small protein from E. coli YccV ...
409-506 7.53e-45

hemimethylated DNA binding domain; This model describes the small protein from E. coli YccV and its homologs in other Proteobacteria. YccV is now described as a hemimethylated DNA binding protein. The model also describes a domain in longer eukaryotic proteins.


Pssm-ID: 131152  Cd Length: 101  Bit Score: 153.30  E-value: 7.53e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051436   409 DVCYSIGLIMKHKRYGYNCVIYGWDPTCMMGHEWIRNMNVHSLPHgHHQPFYNVLVEDGSCR----YAAQENLEYNVEPQ 484
Cdd:TIGR02097   1 AAKFRIGQVVRHKLFGYRGVVIDVDPEYSNTEEWLDAIPVEIRPL-RDQPFYHVLAEDDEGLpyvaYVAEQNLLYDDSDE 79
                          90       100
                  ....*....|....*....|..
gi 71051436   485 EISHPDVGRYFSEFTGTHYIPN 506
Cdd:TIGR02097  80 PIEHPQVDELFDGFDEGLQKPR 101
Transglut_core2 pfam13369
Transglutaminase-like superfamily;
131-304 7.74e-44

Transglutaminase-like superfamily;


Pssm-ID: 463859  Cd Length: 155  Bit Score: 152.70  E-value: 7.74e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051436   131 KDIQAQIDSIVELVCKTLRGINSrhpslafkagessmimeielQSQVLDAMNYVLYDQLKFKGNRMDYYNALNLYMHQVL 210
Cdd:pfam13369   1 EAVLAELDALAAEVRARLPAELD--------------------PLEKLEALNRLLFGELGFKGNSEDYYDPDNSYLDQVL 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051436   211 IRRTGIPISMSLLYLTIARQLGVPLEPVNFPSHFLLRWCQGAEGatldifdYIYIDAFGKGKQLTVKECEYL----IGQH 286
Cdd:pfam13369  61 ERRRGIPISLGVIYLELARRLGLPLYGVNFPGHFLLRVDDTPDG-------EVYIDPFNGGEILSREDLEELlkgnLGPS 133
                         170       180
                  ....*....|....*....|
gi 71051436   287 V--TAALYGVVNVKKVLQRM 304
Cdd:pfam13369 134 AelDPEFLAPASNREILLRM 153
SirB1 COG2912
Regulator of sirC expression, contains transglutaminase-like and TPR domains [Signal ...
102-361 3.30e-40

Regulator of sirC expression, contains transglutaminase-like and TPR domains [Signal transduction mechanisms];


Pssm-ID: 442156 [Multi-domain]  Cd Length: 264  Bit Score: 146.51  E-value: 3.30e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051436 102 LQQPDDYESYLEGAVYIDQYCNPlsDISLKDIQAQIDSIVELVCKtlrginsrhpslafkagessMIMEIELQSQVLDAM 181
Cdd:COG2912   4 IALFDEQIDLAEAALLIAQDEYP--DLDIEQYLAQLDALAAELRE--------------------RLPAEADPLERLEAL 61
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051436 182 NYVLYDQLKFKGNRMDYYNALNLYMHQVLIRRTGIPISMSLLYLTIARQLGVPLEPVNFPSHFLLRwCQGAEGatldifd 261
Cdd:COG2912  62 NQLLYGELGFAGNDEDYYDPDNSYLNKVLDRRRGIPISLGILYLELARRLGLPLYGVNFPGHFLLR-VDLPDG------- 133
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051436 262 YIYIDAFGkGKQLTVKECEYL----IGQHV--TAALYGVVNVKKVLQRMVGNLLSLGKREgidQSYQLLRDSLDLYLAMY 335
Cdd:COG2912 134 PVFIDPFN-GEILSEEELEELlkglLGPPAelEPEFLAPASNREILARMLRNLKAAYLRE---KDWERALRVVERLLLLD 209
                       250       260
                ....*....|....*....|....*.
gi 71051436 336 PDQVQLLLLQARLYFHLGIWPEKVLD 361
Cdd:COG2912 210 PDDPYEIRDRGLLYAQLGCYQAALED 235
YccV-like pfam08755
Hemimethylated DNA-binding protein YccV like; YccV is a hemimethylated DNA binding protein ...
410-502 2.57e-37

Hemimethylated DNA-binding protein YccV like; YccV is a hemimethylated DNA binding protein which has been shown to regulate dnaA gene expression. The structure of one of the hypothetical proteins in this family has been solved and it forms a beta sheet structure with a terminating alpha helix.


Pssm-ID: 430193  Cd Length: 96  Bit Score: 132.72  E-value: 2.57e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051436   410 VCYSIGLIMKHKRYGYNCVIYGWDPTCMMGHEWIRNMNVHSLphGHHQPFYNVLVED-----GSCRYAAQENLEYNVEPQ 484
Cdd:pfam08755   1 VKFRIGQVVRHRRYGYRGVIVGWDPECAASEEWIEQMGVDSL--GRDQPFYHVLVDNedgsyVSVRYVAEENLEPDESGE 78
                          90
                  ....*....|....*...
gi 71051436   485 EISHPDVGRYFSEFTGTH 502
Cdd:pfam08755  79 PIDHPEIGKYFKRFDGGR 96
YccV-like smart00992
Hemimethylated DNA-binding protein YccV like; YccV is a hemimethylated DNA binding protein ...
409-504 6.65e-35

Hemimethylated DNA-binding protein YccV like; YccV is a hemimethylated DNA binding protein which has been shown to regulate dnaA gene expression. The structure of one of the hypothetical proteins in this family has been solved and it forms a beta sheet structure with a terminating alpha helix.


Pssm-ID: 214961  Cd Length: 98  Bit Score: 126.58  E-value: 6.65e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051436    409 DVCYSIGLIMKHKRYGYNCVIYGWDPTCMMGHEWIRNMNVHSLPHgHHQPFYNVLVEDG---SCRYAAQENLEYNVEPQE 485
Cdd:smart00992   1 HAKFRIGQVVRHKLFGYRGVVFDWDPEFANTEEWYDEIPEDSRPP-RDQPFYHVLVENDdssYVAYVSEQNLEPDTSGEP 79
                           90
                   ....*....|....*....
gi 71051436    486 ISHPDVGRYFSEFTGTHYI 504
Cdd:smart00992  80 IDHPLLDELFDEFDGGRYV 98
PRK10941 PRK10941
tetratricopeptide repeat-containing protein;
169-247 2.40e-07

tetratricopeptide repeat-containing protein;


Pssm-ID: 182854 [Multi-domain]  Cd Length: 269  Bit Score: 52.32  E-value: 2.40e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71051436  169 MEIELQsqvLDAMNYVLYDQLKFKGNRMDYYNALNLYMHQVLIRRTGIPISMSLLYLTIARQLGVPLEPVNFPSHFLLR 247
Cdd:PRK10941  53 LPQDEQ---LEKLIALFYGEWGFGGASGVYRLSDALWLDKVLKTRQGSAVSLGAILLWIANRLDLPLMPVIFPTQLILR 128
 
Name Accession Description Interval E-value
yccV TIGR02097
hemimethylated DNA binding domain; This model describes the small protein from E. coli YccV ...
409-506 7.53e-45

hemimethylated DNA binding domain; This model describes the small protein from E. coli YccV and its homologs in other Proteobacteria. YccV is now described as a hemimethylated DNA binding protein. The model also describes a domain in longer eukaryotic proteins.


Pssm-ID: 131152  Cd Length: 101  Bit Score: 153.30  E-value: 7.53e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051436   409 DVCYSIGLIMKHKRYGYNCVIYGWDPTCMMGHEWIRNMNVHSLPHgHHQPFYNVLVEDGSCR----YAAQENLEYNVEPQ 484
Cdd:TIGR02097   1 AAKFRIGQVVRHKLFGYRGVVIDVDPEYSNTEEWLDAIPVEIRPL-RDQPFYHVLAEDDEGLpyvaYVAEQNLLYDDSDE 79
                          90       100
                  ....*....|....*....|..
gi 71051436   485 EISHPDVGRYFSEFTGTHYIPN 506
Cdd:TIGR02097  80 PIEHPQVDELFDGFDEGLQKPR 101
Transglut_core2 pfam13369
Transglutaminase-like superfamily;
131-304 7.74e-44

Transglutaminase-like superfamily;


Pssm-ID: 463859  Cd Length: 155  Bit Score: 152.70  E-value: 7.74e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051436   131 KDIQAQIDSIVELVCKTLRGINSrhpslafkagessmimeielQSQVLDAMNYVLYDQLKFKGNRMDYYNALNLYMHQVL 210
Cdd:pfam13369   1 EAVLAELDALAAEVRARLPAELD--------------------PLEKLEALNRLLFGELGFKGNSEDYYDPDNSYLDQVL 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051436   211 IRRTGIPISMSLLYLTIARQLGVPLEPVNFPSHFLLRWCQGAEGatldifdYIYIDAFGKGKQLTVKECEYL----IGQH 286
Cdd:pfam13369  61 ERRRGIPISLGVIYLELARRLGLPLYGVNFPGHFLLRVDDTPDG-------EVYIDPFNGGEILSREDLEELlkgnLGPS 133
                         170       180
                  ....*....|....*....|
gi 71051436   287 V--TAALYGVVNVKKVLQRM 304
Cdd:pfam13369 134 AelDPEFLAPASNREILLRM 153
SirB1 COG2912
Regulator of sirC expression, contains transglutaminase-like and TPR domains [Signal ...
102-361 3.30e-40

Regulator of sirC expression, contains transglutaminase-like and TPR domains [Signal transduction mechanisms];


Pssm-ID: 442156 [Multi-domain]  Cd Length: 264  Bit Score: 146.51  E-value: 3.30e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051436 102 LQQPDDYESYLEGAVYIDQYCNPlsDISLKDIQAQIDSIVELVCKtlrginsrhpslafkagessMIMEIELQSQVLDAM 181
Cdd:COG2912   4 IALFDEQIDLAEAALLIAQDEYP--DLDIEQYLAQLDALAAELRE--------------------RLPAEADPLERLEAL 61
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051436 182 NYVLYDQLKFKGNRMDYYNALNLYMHQVLIRRTGIPISMSLLYLTIARQLGVPLEPVNFPSHFLLRwCQGAEGatldifd 261
Cdd:COG2912  62 NQLLYGELGFAGNDEDYYDPDNSYLNKVLDRRRGIPISLGILYLELARRLGLPLYGVNFPGHFLLR-VDLPDG------- 133
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051436 262 YIYIDAFGkGKQLTVKECEYL----IGQHV--TAALYGVVNVKKVLQRMVGNLLSLGKREgidQSYQLLRDSLDLYLAMY 335
Cdd:COG2912 134 PVFIDPFN-GEILSEEELEELlkglLGPPAelEPEFLAPASNREILARMLRNLKAAYLRE---KDWERALRVVERLLLLD 209
                       250       260
                ....*....|....*....|....*.
gi 71051436 336 PDQVQLLLLQARLYFHLGIWPEKVLD 361
Cdd:COG2912 210 PDDPYEIRDRGLLYAQLGCYQAALED 235
YccV-like pfam08755
Hemimethylated DNA-binding protein YccV like; YccV is a hemimethylated DNA binding protein ...
410-502 2.57e-37

Hemimethylated DNA-binding protein YccV like; YccV is a hemimethylated DNA binding protein which has been shown to regulate dnaA gene expression. The structure of one of the hypothetical proteins in this family has been solved and it forms a beta sheet structure with a terminating alpha helix.


Pssm-ID: 430193  Cd Length: 96  Bit Score: 132.72  E-value: 2.57e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051436   410 VCYSIGLIMKHKRYGYNCVIYGWDPTCMMGHEWIRNMNVHSLphGHHQPFYNVLVED-----GSCRYAAQENLEYNVEPQ 484
Cdd:pfam08755   1 VKFRIGQVVRHRRYGYRGVIVGWDPECAASEEWIEQMGVDSL--GRDQPFYHVLVDNedgsyVSVRYVAEENLEPDESGE 78
                          90
                  ....*....|....*...
gi 71051436   485 EISHPDVGRYFSEFTGTH 502
Cdd:pfam08755  79 PIDHPEIGKYFKRFDGGR 96
YccV-like smart00992
Hemimethylated DNA-binding protein YccV like; YccV is a hemimethylated DNA binding protein ...
409-504 6.65e-35

Hemimethylated DNA-binding protein YccV like; YccV is a hemimethylated DNA binding protein which has been shown to regulate dnaA gene expression. The structure of one of the hypothetical proteins in this family has been solved and it forms a beta sheet structure with a terminating alpha helix.


Pssm-ID: 214961  Cd Length: 98  Bit Score: 126.58  E-value: 6.65e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051436    409 DVCYSIGLIMKHKRYGYNCVIYGWDPTCMMGHEWIRNMNVHSLPHgHHQPFYNVLVEDG---SCRYAAQENLEYNVEPQE 485
Cdd:smart00992   1 HAKFRIGQVVRHKLFGYRGVVFDWDPEFANTEEWYDEIPEDSRPP-RDQPFYHVLVENDdssYVAYVSEQNLEPDTSGEP 79
                           90
                   ....*....|....*....
gi 71051436    486 ISHPDVGRYFSEFTGTHYI 504
Cdd:smart00992  80 IDHPLLDELFDEFDGGRYV 98
PRK10941 PRK10941
tetratricopeptide repeat-containing protein;
169-247 2.40e-07

tetratricopeptide repeat-containing protein;


Pssm-ID: 182854 [Multi-domain]  Cd Length: 269  Bit Score: 52.32  E-value: 2.40e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71051436  169 MEIELQsqvLDAMNYVLYDQLKFKGNRMDYYNALNLYMHQVLIRRTGIPISMSLLYLTIARQLGVPLEPVNFPSHFLLR 247
Cdd:PRK10941  53 LPQDEQ---LEKLIALFYGEWGFGGASGVYRLSDALWLDKVLKTRQGSAVSLGAILLWIANRLDLPLMPVIFPTQLILR 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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