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Conserved domains on  [gi|39992338|gb|AAH64409|]
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HIAT1 protein, partial [Homo sapiens]

Protein Classification

MFSD14 family MFS transporter( domain architecture ID 13024393)

MFSD14 family major facilitator superfamily (MFS) transporter such as MFS domain-containing 14A and 14B, also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively; MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26098515|26758938
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 1-334 0e+00

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 547.02  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   1 IPLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLAT 80
Cdd:cd17387  80 IPLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVAT 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  81 AIALLDICFILVAVPESLPEKMRPASWGAPISWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIM 160
Cdd:cd17387 160 IVALLDICFILLAVPESLPEKMRPASWGAPISWEQADPFASLRKVGKDKTVLLICITVFLSYLPEAGQYSSFFVYLKQVM 239

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 161 KFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVS 240
Cdd:cd17387 240 GFEYEEVAAFIAVVGILSITAQTLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAIS 319

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 241 ALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHVELKELPITGTDLGTNTSPQhhfEQNSIIPGPPFLFGA 320
Cdd:cd17387 320 ALVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVFYLFHVDLNEIKPVQSSKQRMQNPS---LEGAIIPGPPFLFGA 396

                       330
                ....*....|....
gi 39992338 321 CSVLLALLVALFIP 334
Cdd:cd17387 397 ISVLLAILVASFIP 410
 
Name Accession Description Interval E-value
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 1-334 0e+00

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 547.02  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   1 IPLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLAT 80
Cdd:cd17387  80 IPLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVAT 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  81 AIALLDICFILVAVPESLPEKMRPASWGAPISWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIM 160
Cdd:cd17387 160 IVALLDICFILLAVPESLPEKMRPASWGAPISWEQADPFASLRKVGKDKTVLLICITVFLSYLPEAGQYSSFFVYLKQVM 239

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 161 KFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVS 240
Cdd:cd17387 240 GFEYEEVAAFIAVVGILSITAQTLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAIS 319

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 241 ALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHVELKELPITGTDLGTNTSPQhhfEQNSIIPGPPFLFGA 320
Cdd:cd17387 320 ALVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVFYLFHVDLNEIKPVQSSKQRMQNPS---LEGAIIPGPPFLFGA 396

                       330
                ....*....|....
gi 39992338 321 CSVLLALLVALFIP 334
Cdd:cd17387 397 ISVLLAILVASFIP 410
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
7-269 4.17e-23

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 98.89  E-value: 4.17e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   7 SPWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALL 85
Cdd:COG2814  97 SLWLLLAARFLQGLGaGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALL 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  86 DICFILVAVPESLPEKMRPASwgapisweqadpfASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPE 165
Cdd:COG2814 177 ALLLLLRLLPESRPAARARLR-------------GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSAS 243

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 166 SVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSALVS 244
Cdd:COG2814 244 AAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQALVA 322

                       250       260
                ....*....|....*....|....*
gi 39992338 245 RTADADQQGVVQGMITGIRGLCNGL 269
Cdd:COG2814 323 ELAPPEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
1-271 2.78e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 82.08  E-value: 2.78e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338     1 IPLMKISPWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLA 79
Cdd:pfam07690  78 LLLFASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338    80 TAIALldICFILVAVPESLPEKMRPASWGApISWEQADPFASLKKVGQDSIVLLICITVFLSYLpeagqYSSFFLYLRQI 159
Cdd:pfam07690 158 AILSL--LAAVLLLLPRPPPESKRPKPAEE-ARLSLIVAWKALLRDPVLWLLLALLLFGFAFFG-----LLTYLPLYQEV 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   160 MKFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQIL---QLAWYGFGSEPWMMWAAGAVAAMS-SIT 235
Cdd:pfam07690 230 LGLSALLAGLLLGLGGLLGAIGR-LLLGRLSDRLGRRRRLLLALLLLILaalGLLLLSLTLSSLWLLLALLLLGFGfGLV 308

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 39992338   236 FPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGP 271
Cdd:pfam07690 309 FPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 1-334 0e+00

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 547.02  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   1 IPLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLAT 80
Cdd:cd17387  80 IPLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVAT 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  81 AIALLDICFILVAVPESLPEKMRPASWGAPISWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIM 160
Cdd:cd17387 160 IVALLDICFILLAVPESLPEKMRPASWGAPISWEQADPFASLRKVGKDKTVLLICITVFLSYLPEAGQYSSFFVYLKQVM 239

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 161 KFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVS 240
Cdd:cd17387 240 GFEYEEVAAFIAVVGILSITAQTLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAIS 319

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 241 ALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHVELKELPITGTDLGTNTSPQhhfEQNSIIPGPPFLFGA 320
Cdd:cd17387 320 ALVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVFYLFHVDLNEIKPVQSSKQRMQNPS---LEGAIIPGPPFLFGA 396

                       330
                ....*....|....
gi 39992338 321 CSVLLALLVALFIP 334
Cdd:cd17387 397 ISVLLAILVASFIP 410
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 6-281 5.33e-47

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 163.52  E-value: 5.33e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   6 ISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALL 85
Cdd:cd17330  85 RNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALL 164

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  86 DICFILVAVPeslpekmrpaswgapisweqadpfaslkkvgqdsIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPE 165
Cdd:cd17330 165 NLVLVLFFLP----------------------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPS 210

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 166 SVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSE-PWMMWAAGAVAAMSSITFPAVSALVS 244
Cdd:cd17330 211 QIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSvPLLVLAAAILAFGTGIVFPALSALLS 290

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 39992338 245 RTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 281
Cdd:cd17330 291 KSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFL 327
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 3-281 1.39e-36

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 136.61  E-value: 1.39e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   3 LMKISP--WWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGrVYGDSLVVVLAT 80
Cdd:cd17388  84 LMAFAPtlWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLG-EISPRAPFLVAA 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  81 AIALLDICFILVAVPESLPEKMRPASwgapiSWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIM 160
Cdd:cd17388 163 GLNGLNFLLGLFVLPESLPPERRRAF-----RWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRF 237

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 161 KFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVS 240
Cdd:cd17388 238 DWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQ 317

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 39992338 241 ALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 281
Cdd:cd17388 318 GLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAAS 358
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 7-282 8.95e-24

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 101.11  E-value: 8.95e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   7 SPWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALL 85
Cdd:cd17325  83 SYWQLLLARFLQGLAsAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  86 DICFILVAVPESLPEKmrpaswgAPISWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPE 165
Cdd:cd17325 163 ALVLALLLLPEPRPPP-------NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPA 235

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 166 SVAAFIAVLGILSIIAQTIVLSLLMRsIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVA-AMSSITFPAVSALVS 244
Cdd:cd17325 236 QIGLLFGAQGLASALSQPPAGKLSDR-IGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLgLGLGLVFPATLALLA 314

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 39992338 245 RTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFH 282
Cdd:cd17325 315 DIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG 352
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
7-269 4.17e-23

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 98.89  E-value: 4.17e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   7 SPWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALL 85
Cdd:COG2814  97 SLWLLLAARFLQGLGaGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALL 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  86 DICFILVAVPESLPEKMRPASwgapisweqadpfASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPE 165
Cdd:COG2814 177 ALLLLLRLLPESRPAARARLR-------------GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSAS 243

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 166 SVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSALVS 244
Cdd:COG2814 244 AAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQALVA 322

                       250       260
                ....*....|....*....|....*
gi 39992338 245 RTADADQQGVVQGMITGIRGLCNGL 269
Cdd:COG2814 323 ELAPPEARGRASGLYNSAFFLGGPL 347
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 7-281 6.64e-21

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 92.68  E-value: 6.64e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   7 SPWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGrVYGDSLVVVLATAIALL 85
Cdd:cd17329  87 SPWLFAIALVLTGFGgGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLFLAAAVLFLL 165

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  86 DICFILVAVPESLPEKMRPaswgapiswEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPE 165
Cdd:cd17329 166 AALVLLFLLPETRPKRRAA---------EKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGES 236

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 166 SVAAFIAVLGILSIIAQTIVlSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAM-SSITFPAVSALVS 244
Cdd:cd17329 237 LLGLLLALNALLIVLLQFPV-ARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLgEMLVFPAVQTLVA 315

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 39992338 245 RTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 281
Cdd:cd17329 316 ALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLL 352
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 7-282 7.46e-18

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 84.02  E-value: 7.46e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   7 SPWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALL 85
Cdd:cd06174  83 SFWLLLLGRFLLGLGsGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALA 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  86 DICFIL-VAVPESLPEKMRPaswgAPISWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSP 164
Cdd:cd06174 163 LLAAILlLLVVPDPPESARA----KNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSV 238

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 165 ESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGA-VAAMSSITFPAVSALV 243
Cdd:cd06174 239 AVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLlLGFGLGGLLPLSFALI 318

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 39992338 244 SRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFH 282
Cdd:cd06174 319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
MFS_1 pfam07690
Major Facilitator Superfamily;
1-271 2.78e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 82.08  E-value: 2.78e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338     1 IPLMKISPWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLA 79
Cdd:pfam07690  78 LLLFASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338    80 TAIALldICFILVAVPESLPEKMRPASWGApISWEQADPFASLKKVGQDSIVLLICITVFLSYLpeagqYSSFFLYLRQI 159
Cdd:pfam07690 158 AILSL--LAAVLLLLPRPPPESKRPKPAEE-ARLSLIVAWKALLRDPVLWLLLALLLFGFAFFG-----LLTYLPLYQEV 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   160 MKFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQIL---QLAWYGFGSEPWMMWAAGAVAAMS-SIT 235
Cdd:pfam07690 230 LGLSALLAGLLLGLGGLLGAIGR-LLLGRLSDRLGRRRRLLLALLLLILaalGLLLLSLTLSSLWLLLALLLLGFGfGLV 308

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 39992338   236 FPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGP 271
Cdd:pfam07690 309 FPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 7-278 2.74e-16

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 79.57  E-value: 2.74e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   7 SPWWYFavIS-VSGVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALL 85
Cdd:cd17331  87 SVPMLF--LSrLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLL 164

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  86 DICfILVAVPESLPEKMRPASWGAPISWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPE 165
Cdd:cd17331 165 SIV-LVILLIPSNTKSKREKEAKESASPPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPE 243

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 166 SVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGF-GSEPWMMWAAGAVAAMSSITFPAVSALVS 244
Cdd:cd17331 244 ENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFvTTVWQLLVLLLPLVIGGSVLYTVITSLLT 323

                       250       260       270
                ....*....|....*....|....*....|....
gi 39992338 245 RTADADQQGVVQGMITGIRGLCNGLGPALYGFIF 278
Cdd:cd17331 324 KAVPPEDTGTALGLSHALFSLVRTVSPTIGGALL 357
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
8-277 5.12e-16

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 79.18  E-value: 5.12e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   8 PWWYFAVISVsgVFAVTFSVVF----AYVADITQE-HERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDS-----LVVV 77
Cdd:COG2211 109 KLIYALVTYL--LLGLAYTLVNipysALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDaalgyRLTA 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  78 LATAIALLdICFILVAVpeSLPEKMRPASwgapiswEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLR 157
Cdd:COG2211 187 LIFAVLGL-LAFLLTFF--GTKERPVPEE-------EKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFK 256

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 158 QIMKFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGF--GSEPWMMWAAGAVAAM-SSI 234
Cdd:COG2211 257 YVLGLSAALVGLLLALYFLAALLG-APLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlgPGNLWLLLVLAALAGIgLGA 335

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 39992338 235 TFPAVSALVSRTADADQQ-------GVVQGMITGIRGLCNGLGPALYGFI 277
Cdd:COG2211 336 ILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLL 385
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 6-283 1.04e-12

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 68.80  E-value: 1.04e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   6 ISPWWYFAVISVSGVFAVTFSVVF-AYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATaial 84
Cdd:cd06173  90 LSLWLLLVLAFLLGIASAFFGPARqALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA---- 165

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  85 ldICFILVAVPESLPEKMRPASWGAPISWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSP 164
Cdd:cd06173 166 --LSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGA 243

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 165 ESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITF-PAVSALV 243
Cdd:cd06173 244 AGYGLLLAAFGVGALLG-ALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFnVPLNTLL 322

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 39992338 244 SRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHV 283
Cdd:cd06173 323 QLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGL 362
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 7-278 1.35e-12

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 68.34  E-value: 1.35e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   7 SPWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALL 85
Cdd:cd17324  86 SFALLLLARALAGLAhGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALL 165

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  86 DICFILVAVPESLPEKMRPASwgapisweqadPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPE 165
Cdd:cd17324 166 AALLLWRLLPSLPPKKPGSLG-----------LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSS 234

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 166 SVAAFIAVLGILSIIAQTIVLSLLMRsIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAV-AAMSSITFPAVSALVS 244
Cdd:cd17324 235 AIIGLLLLFGVAGVVGSPLAGRLADR-GGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLwGLGFFAAHSALQTRVL 313

                       250       260       270
                ....*....|....*....|....*....|....
gi 39992338 245 RTAdADQQGVVQGMITGIRGLCNGLGPALYGFIF 278
Cdd:cd17324 314 RLA-PEARGLASSLYLAAYNLGGALGAALGGLVL 346
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 6-278 2.36e-12

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 67.30  E-value: 2.36e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   6 ISPWWYF---AVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAI 82
Cdd:cd17386  87 PSVWWFYlsaIPLALFGGFTAFLSASFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAAL 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  83 ALLDICFILVAVpeslpekmrpaswgapisweqadpfaslkkvgqdSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKF 162
Cdd:cd17386 167 LLIALLYILFFL----------------------------------TLLILLLLAAFLTIFVLSGESDVLYLFVLEKFAW 212

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 163 SPESVAAFIAvLGILSIIAQTIVLSLLMRSIGNKN---TILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAV 239
Cdd:cd17386 213 NVKDFSYFST-LGSLIYLTGMLGGVLLLRCLLKMSdstLAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNGIVGPMI 291

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 39992338 240 SALVSRTADADQqgvvQGMITGIRGLCNGLGPALYGFIF 278
Cdd:cd17386 292 RSILSKLVPKSE----QGKIFSLLSVLESLSPLVASPIY 326
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
7-277 7.96e-12

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 66.03  E-value: 7.96e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   7 SPWWYFAVISVSGV-FAVTFSVVFAYVADITQEHERSMaYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALL 85
Cdd:COG0738  95 SYPLLLLALFLLGLgLGLLDVAANPYVAALGPETAASR-LNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVL 173

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  86 DICFILVAVPESLPEKMRPASwgapiswEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPE 165
Cdd:COG0738 174 LLLLALLFLRSKLPEIEEEEE-------EAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEA 246

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 166 SVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWM-MWAAGAVAAMSSITFPAVSALVS 244
Cdd:COG0738 247 TAALGLSLFWGGMTIGR-FLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLaLIGLALVGLGLSLMFPTIFSLAL 325

                       250       260       270
                ....*....|....*....|....*....|...
gi 39992338 245 RTADADQQGVVqGMITGIRGLCNGLGPALYGFI 277
Cdd:COG0738 326 DGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFL 357
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 7-278 8.92e-10

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 59.59  E-value: 8.92e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   7 SPWWYFAVISVSGVF--AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYG-DSLVVVLATAIA 83
Cdd:cd17355  90 SLWQLYLLWGLLGGGgaGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGwRTALLVLALLAL 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  84 LLDICFILVAVPESLPEKMRPASWGAPisweqADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQImKFS 163
Cdd:cd17355 170 LVLVPVLLLLRRRPADLALRAYDDASP-----ASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR-GIS 243

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 164 PESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEP-WMMWAAGAVAAMSSI-TFPAVSA 241
Cdd:cd17355 244 PAAAAVALALIGLFNIVG-RLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPpLALLLFAALFGLGWGaTVPLTAA 322

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 39992338 242 LVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIF 278
Cdd:cd17355 323 LAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLY 359
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
6-278 4.11e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 57.58  E-value: 4.11e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   6 ISPWWYFAVISVSGVFA-VTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIAL 84
Cdd:COG2223  91 VSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLL 170

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  85 LDICFILVAVPEsLPEKMRPASwgapisweqADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSP 164
Cdd:COG2223 171 VVAVLAWLFLRD-PPAGAAAAA---------KASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSA 240

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 165 ESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQILQLAW--YGFGSEPWMMWAAGAVAAMSSITFPAVSAL 242
Cdd:COG2223 241 ATAGLLAALFALLGALG-RPLGGWLSDRIGGRRVLLIVFALMALGLLLlaLALGSLWLFLVLFLLLGLALGGGNGAVFAL 319

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 39992338 243 VSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIF 278
Cdd:COG2223 320 VPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 21-281 4.16e-09

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 57.58  E-value: 4.16e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  21 FAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRV--YGDSLVVVLATAIALLDICFILvavpESL 98
Cdd:cd17474 101 AAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAIswRYPFFLLAALIPVAFLAILFLL----PEP 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  99 PEKMRPASWGAPISWEQADPFASLKKVGQDSIVLLICITVFLSYLPeagqyssffLYLRQIMKFSPESVAAFIAVLGILS 178
Cdd:cd17474 177 KEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLP---------FLLELLYGISPIIIGLLFAGWSVLL 247

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 179 IIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSS-ITFPAVSALVSRTADADQQGVVQG 257
Cdd:cd17474 248 ALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLgLNLPLLTTLVTELAPEEERGTASS 327

                       250       260
                ....*....|....*....|....
gi 39992338 258 MITGIRGLCNGLGPALYGFIFYIF 281
Cdd:cd17474 328 LYNFVRFLGQAVGPLLFGLLLEIF 351
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 22-279 2.54e-08

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 55.26  E-value: 2.54e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  22 AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALldICFILVavpeslpek 101
Cdd:cd17321  99 AAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGL--VALLLA--------- 167

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 102 mrPASWGApisweqadpfaslkkvgqdsivlliCITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIA 181
Cdd:cd17321 168 --RTFSGA-------------------------VLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVA 220

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 182 qTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSI----TFPAVSALVSRTADADQQGVVQG 257
Cdd:cd17321 221 -APLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLglglFATPLTNAALSSVPKEKAGAASG 299

                       250       260
                ....*....|....*....|..
gi 39992338 258 MITGIRGLCNGLGPALYGFIFY 279
Cdd:cd17321 300 ILNTARQLGGALGVALLGALLT 321
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
7-282 3.04e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 54.88  E-value: 3.04e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   7 SPWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALL 85
Cdd:COG2271  97 SFWQLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLL 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  86 dicfilvavpeslpekmrpasWGAPISWeqadpfaslkkvgqdsivlLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPE 165
Cdd:COG2271 177 ---------------------LALLRFW-------------------LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLA 216

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 166 SVAAFIAVLGILSIIAqTIVLSLLMRSIG--NKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSI-TFPAVSAL 242
Cdd:COG2271 217 QAGLLLSLPFLAGIVG-SLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGgAFGLLWAL 295

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 39992338 243 VSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFH 282
Cdd:COG2271 296 AAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG 335
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 17-278 5.97e-08

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 54.12  E-value: 5.97e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  17 VSGVFAVTFSVV-FAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVP 95
Cdd:cd17320  96 LQGLGAAAGSVVaRAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLP 175

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  96 ESLPEKMRPASWGApisweqadPFASLKKVGQDSIVLLICITVFLSYLPEAGQYS-SFFLYLrQIMKFSPESVAAFIAVL 174
Cdd:cd17320 176 ETLPEEKRKPLLSS--------LLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAaAPFIYI-EQLGLSPAQFGLLFALN 246

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 175 GILSIIAqTIVLSLLMRSIGNKNTILLGLGFQI------LQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRtAD 248
Cdd:cd17320 247 AIALILG-SLLNGRLVRRFGPRRLLRLGLLLLLaaalvlLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALE-PF 324

                       250       260       270
                ....*....|....*....|....*....|
gi 39992338 249 ADQQGVVQGMITGIRGLCNGLGPALYGFIF 278
Cdd:cd17320 325 PHVAGTASALLGFLQFLIGALAGALVGLLP 354
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 24-283 1.34e-07

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 52.97  E-value: 1.34e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  24 TFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLdicfILVAVPESLPEKMR 103
Cdd:cd17504 100 VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVL----LAALVPLIDLRLLR 175

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 104 PASWGAPISweqadpfaslkkvgqdsIVLLICITVFLSY--LPEAGQYSSFFLYLRQIMkfspesVAAFIAVLGILSIIA 181
Cdd:cd17504 176 RRNVLLANI-----------------TALLAGFGMFMVFqlLPQLLQLPTPTGFGLGIT------EAGLLLLPGALVMLI 232

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 182 QTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGF-GSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMI 259
Cdd:cd17504 233 AGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALlHSSLWALVVALLLIGIgLGLAFASLPNIVVESVPPDRTGIATGMN 312

                       250       260
                ....*....|....*....|....
gi 39992338 260 TGIRGLCNGLGPALYGFIFYIFHV 283
Cdd:cd17504 313 TVLRTIGSAIGPAIAGAILTTYTV 336
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 30-281 1.97e-07

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 52.28  E-value: 1.97e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  30 AYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVV------LATAIALLDICFILVAVPESLPEKMR 103
Cdd:cd17389 139 AIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFASFTRSLGEVFfsmpalFALVLALADLLFIFFFLPETLPSNLR 218

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 104 PASWGapisweqadpfaslkkvgqdsivllicitVFLSYLPEAG-QYSSFFLyLRQIMKFSPESVAAFIAVLGILSIIAQ 182
Cdd:cd17389 219 RLGLV-----------------------------YFLYLFLFSGlEFTLTFL-THQRFQYTSMQQGKMFFFIGIIMALVQ 268

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 183 TIVLSLLmRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMITG 261
Cdd:cd17389 269 GGYVRRI-KPGKEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFaAATVVPCLTTLVSGYGSDDQKGTVMGIFRS 347

                       250       260
                ....*....|....*....|
gi 39992338 262 IRGLCNGLGPALYGFIFYIF 281
Cdd:cd17389 348 LGALARALGPIVACTVYWLA 367
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 19-277 4.70e-07

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 51.07  E-value: 4.70e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  19 GVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLdICFILVAVpesl 98
Cdd:cd17390  95 GIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAIFI-LNAGLVWF---- 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  99 pekMRPASWgapisweqaDPFaslkkvgqdSIVLLICITVFLSylpeagqYSSFFLYLRQIMKFSPESVAAFIAVLGILS 178
Cdd:cd17390 170 ---LLSKLW---------DLL---------LVRFLMGFSVLLF-------RSNFSLYLEERFDLSPKTIGYLISYSGVLG 221

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 179 IIAQTIVLSLLmrSIGNKNTILLGLGFQILQ---LAWYGFGSEPWMMWAAGA-VAAMSSITFPAVSALVSRTADADQQGV 254
Cdd:cd17390 222 ALSGFLVGRIL--KLYKNNEYLLLLHSFILLalsLLGLALAPSIWLLVLCLTpLSISSAVLRTCSTSLLLSRGKSKERGT 299

                       250       260
                ....*....|....*....|...
gi 39992338 255 VQGMITGIRGLCNGLGPALYGFI 277
Cdd:cd17390 300 LLGVGQSVTSLARILAPLLSGLL 322
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 22-260 6.23e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 50.65  E-value: 6.23e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  22 AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGR--------VYGDSLVVVLATAIAlldicfilva 93
Cdd:cd17473 103 AGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEigwrapflVYLLALPVLILVLLF---------- 172

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  94 vpesLPEKMRPASwgapiswEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAV 173
Cdd:cd17473 173 ----LPEPARKSK-------SAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAI 241

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 174 LGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQ 252
Cdd:cd17473 242 ASLAGAIG-ALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLgFGLLLPTLNSWAMSLVPPELR 320


                ....*...
gi 39992338 253 GVVQGMIT 260
Cdd:cd17473 321 GRAMGIVT 328
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 7-281 9.17e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 50.29  E-value: 9.17e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   7 SPWWYFAVISVSGV-FAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALL 85
Cdd:cd17489  83 SVALLLVLRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  86 DI--CFILVAVPESLPEKMRPASWGapisweqadPFASLKKVgqdsiVLLICITVFLSYLPEAGQYSSFFLYLRQImkfS 163
Cdd:cd17489 163 ALllVFLVKDPPPVAAEEAEAGTRA---------FRRLVEKK-----VLPPALILFLASIAYGAISTFLPLYAAER---G 225

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 164 PESVAAFIAVLGILSIIAQTIVLSLLMRsIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSAL 242
Cdd:cd17489 226 ISNAGLFFTVYAIALLLSRPFSGKLSDR-KGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfGLLFPALQAL 304

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 39992338 243 VSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 281
Cdd:cd17489 305 AVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELF 343
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 7-278 1.07e-06

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 49.91  E-value: 1.07e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   7 SPWWYFAVISVSGVFAVTfSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLD 86
Cdd:cd17472  84 SIYGLILGRALQGSGAIS-SVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVS 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  87 ICFILVAVPESLPEKMRPASWGapisweqadpfASLKKVGQDSIVLLICITVFLSYLpeagQYSSFF----LYLRQIMKF 162
Cdd:cd17472 163 LLILLFFVPDPPKIVQISEKEK-----------KKLKKLLKNKRLLRLDFSIFILHF----VLMAFFyilpLLLTQLGGG 227

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 163 SPESVAAFIAVLgILSIIAqtIVLSLLMRSIGN--KNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITF--PA 238
Cdd:cd17472 228 KGQLWKVYLPAI-LIGFIL--MVPFVIYAEKKGkmKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLleAL 304

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 39992338 239 VSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIF 278
Cdd:cd17472 305 LPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLW 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 134-281 1.38e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 49.73  E-value: 1.38e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 134 ICITVFLSYLPEAGqYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQLAWY 213
Cdd:cd06174   1 LLLGFFLTGLARGL-ISPLLPALLQSFGLSASQLGLLFALFSLGYALLQ-PLAGLLADRFGRRPVLLLGLLLFALGALLF 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 39992338 214 GFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 281
Cdd:cd06174  79 AFAPSFWLLLLGRFLLGLgSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL 147
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 7-277 2.03e-06

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 49.12  E-value: 2.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   7 SPWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSmaYGLV----SATFAAslvTSPAIGAYLGRVYGD-SLVVVLAT 80
Cdd:cd17335  86 IFWLLLLLVILGAFFsAPVVPLVDSITLQYLGEERER--YGKQrlwgSIGFGI---AALLVGILIDRSSTYkNYTIAFYV 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  81 AIALLDICFILVAvpeslpeKMRPASWGAPISWEQADPFASLKKVGqdsiVLLICITVFLSYLPEAGQYSSFFLYLRQIM 160
Cdd:cd17335 161 FAVLMLLALLLAL-------KFPFRPKHPEPNENTGGLLALLRNPR----VLAFLLVAFLMGFGHGLIYSFLFWHLQDLG 229

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 161 kfSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMwaaGAVAAMSSITFPAV- 239
Cdd:cd17335 230 --GSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLV---LPIELLHGLTFALVw 304

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 39992338 240 ---SALVSRTADADQQGVVQGMITgirGLCNGLGPALYGFI 277
Cdd:cd17335 305 aaaVSYASAAAPPGLRATAQGLLQ---GLYFGLGGGLGSLI 342
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 30-284 2.05e-06

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 49.08  E-value: 2.05e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  30 AYVADITQEHERSMAYGLVSA--TFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESlPEKMRPasw 107
Cdd:cd17370 111 ALLADATPPSGRGKAFGLHRAldTLGAVLGPLLAALLLYLLGGNYRTIFLLAAIPALLALLILLFVVKEY-PRPPKL--- 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 108 gapiswEQADPFASLKKVGQDSIVLLICITVFlsylpEAGQYS-SFFLYLRQIMKFSPESVAAFIAVLGILSIIAqTIVL 186
Cdd:cd17370 187 ------RKKSKKTSLKKLPKAFWLYLLAVALF-----ALGNFSfAFLILRAQELGLSAALIPLLYALFNLVYALA-AYPA 254

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 187 SLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSALVSRTADADQQGVVQGMITGIRGL 265
Cdd:cd17370 255 GRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTAYGLFNTVVGI 334

                       250
                ....*....|....*....
gi 39992338 266 CNGLGPALYGFIFYIFHVE 284
Cdd:cd17370 335 GWLLASLIAGYLWDLISPS 353
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
130-282 2.53e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 48.82  E-value: 2.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 130 IVLLICITVFLSYLpEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQ 209
Cdd:COG2814  11 ALLALALGAFLSGL-GIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGA-PLAGRLADRFGRRRVLLLGLLLFALG 88

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 39992338 210 LAWYGFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFH 282
Cdd:COG2814  89 SLLCALAPSLWLLLAARFLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 9-278 3.39e-06

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 48.76  E-value: 3.39e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   9 WWYFAVISVSGVFAVTFSVVF-AYVADITQE-HERS--MAYGLVSATFAASLVTS--PAIGAYLGRVYGDSLVVVLATAI 82
Cdd:cd17332 100 IYALITYILLDLLYTLVNIPYtALIPELTDDpEERTslTSWRMFFATIGGLLVTVlpPPLVAYFGGGNASRGYFLTALII 179

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  83 ALLDICFILVAVPESlpEKMRPASWGAPISWEQADPFASLKKvgQDSIVLLICITVFLSYLPEAGQySSFFLYLRQIMKF 162
Cdd:cd17332 180 GIIGIILLLICFFGT--RERVVPPEEEKSKLPLLKSLKALLK--NRPFLILLLAYLLYFLAFNIVN-TVLVYYFKYVLGG 254

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 163 SPESVAAFIAVLGILSIIaqTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEP--WMMWAAGAVAAM-SSITFPAV 239
Cdd:cd17332 255 RAELVLLLLLILSGALLA--LLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGnlVLILVLAVLAGIgYGGANLLP 332

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 39992338 240 SALVSRTADADQ--QGV-VQGMITGIRGLCNGLGPALYGFIF 278
Cdd:cd17332 333 WAMLADVIDYGElkTGKrREGIFYSVMTFFRKLGLALAGALV 374
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
130-281 4.95e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 44.86  E-value: 4.95e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 130 IVLLICITVFLSYLPEAGqYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQ 209
Cdd:COG2271  11 ILALLFLAYFLNYLDRSN-LSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQ-IPAGLLADRFGRRRVLAIGLLLWGLA 88

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 39992338 210 LAWYGFGSEPWMMWAA-GAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 281
Cdd:COG2271  89 TLLFGFATSFWQLLLLrFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 7-282 5.17e-05

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 44.76  E-value: 5.17e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   7 SPWWYFAVISVSGVFAVTFSVVF--AYVADITQEHER--------SMAY--GLVSATFAASLVTSPAIGAYLGRVYGDSL 74
Cdd:COG2270 106 GGLWLGLLLFVLANIGFEGSLVFynAFLPDIATPEEIgrvsglgwALGYlgGVLLLLINLALFLKPEAFGLPDAGEAVRI 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  75 VVVLATAIALLDICFILVAVPESLPEKMRPASWGAPISWEQAdpFASLKKVGQDSIVL--LICITVFLSYLpeAGQYSSF 152
Cdd:COG2270 186 SFLLTALWWLLFALPLFLFLPERPRPGPAPPRGAVRAGFREL--RRTLRELRRYRDLLrfLLAYFFYRDGV--QTVIAFA 261

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 153 FLYLRQIMKFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS 232
Cdd:COG2270 262 GIYAAGVLGFSTTELIVFGLLVQIVAALG-ALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLV 340

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 39992338 233 SITFPAVS-ALVSRTADADQQGV------VQGMITGIrglcngLGPALYGFIFYIFH 282
Cdd:COG2270 341 MGGIQALSrSLLARLIPPGREAEffglyaLSGKAASF------LGPLLFGLVTQLTG 391
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 7-94 1.37e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 43.33  E-value: 1.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   7 SPWWYFAVISVSGV-FAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALL 85
Cdd:cd17325 287 SFWLLLLLLALLGLgLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLL 366


                ....*....
gi 39992338  86 DICFILVAV 94
Cdd:cd17325 367 AAVLFLLLR 375
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
162-278 5.14e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 41.78  E-value: 5.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 162 FSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSA 241
Cdd:COG2807 247 LSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALT 326

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 39992338 242 LVS-RTADADQQGVVQGMITGIRGLCNGLGPALYGFIF 278
Cdd:COG2807 327 LIGlRARTPAEAAALSGMAQSVGYLLAALGPLLVGALH 364
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 7-236 6.67e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 41.39  E-value: 6.67e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   7 SPWWYFAVISVSGVFAVTFSVVF-AYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGrVYGDS--LVVVLATAIA 83
Cdd:cd17477  83 SPWVWFLLRFVMGIGLAGLFVVSeSWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVG-TAGALpfLIAAVLLLLA 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  84 LLDICFILVAVPESlpekmrpaswgapiswEQADPFASLKKVgqdSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMkFS 163
Cdd:cd17477 162 LVPLLLTRRAAPEI----------------EEAESISLRRLL---RIAPLALLGAFVAGFLEGAFYSLLPLYGLRLG-LS 221

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 39992338 164 PESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITF 236
Cdd:cd17477 222 VAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPL 294
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 11-282 1.07e-03

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 40.76  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338    11 YFAVISVSGVFAVTFSVV--FAYVADITQE-HERS---------MAYGLVSATFAASLVTSPAIGAYLGRVyGDSLVVVL 78
Cdd:pfam13347  99 WLLATYILLRIAYTFFEIpyWSLGPELTRDyDERTsltsyrsffSVGGGLLAAALAFPLVLILGGTGLERK-GYRIFALI 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338    79 ATAIALLDICFILVAVPESLPEKMRPASWGApiswEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQ 158
Cdd:pfam13347 178 GAVLMLLGVIITAAGTKERVSMRSKEDTGQK----EAGSLLDMLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRY 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   159 IMKFspESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQI--LQLAWYGFGSEPWMMWAAGAVAAMSSIT- 235
Cdd:pfam13347 254 VLGN--GFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIagFALALLLGPNNTLLFLVLYIIIGFGYGSs 331

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 39992338   236 FPAVSALVSRTADADQ---QGVVQGMITGIRGLCN----GLGPALYGFIFYIFH 282
Cdd:pfam13347 332 FFLPWSMLADVVDYGElrtGKRREGTFFAMWSFISklatGVGLGVSGLLLSAFG 385
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
130-278 1.42e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 40.25  E-value: 1.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 130 IVLLICITVFLSYLPEAGqYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQ 209
Cdd:COG2223   6 VLLLATLAFFLAFGVWYL-WSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLR-IPLGFLVDRFGPRRVLLIGLLLLGIG 83

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 210 LAWYGFGSEPWMMWAAGAVAAMSS-ITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIF 278
Cdd:COG2223  84 LLLLALAVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI 153
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 22-194 3.69e-03

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 38.64  E-value: 3.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  22 AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDIcFILVAVPESLPEK 101
Cdd:COG0477 117 GGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLAL-VLRLRLPESRGLL 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 102 MRPASWGAPISWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIA 181
Cdd:COG0477 196 LALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALL 275

                       170
                ....*....|...
gi 39992338 182 QTIVLSLLMRSIG 194
Cdd:COG0477 276 LALLLLLLLLLLL 288
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 6-85 3.84e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 39.06  E-value: 3.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   6 ISPWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIAL 84
Cdd:cd17370 285 SSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLAL 364


                .
gi 39992338  85 L 85
Cdd:cd17370 365 I 365
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 133-276 4.35e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 38.71  E-value: 4.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 133 LICITVFLSYLPeagqyssFFLYLRQIMKFSPESVAAFIAVLGILSIIAQTIVLSLLMRsIGNKNTILLGLGFQILQLAW 212
Cdd:cd17330   9 ALGFGIVFPVLP-------FYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDR-YGRKPVLLLSLAGSAVSYVL 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 39992338 213 YGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGF 276
Cdd:cd17330  81 LGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGF 144
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 7-222 4.86e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 38.68  E-value: 4.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   7 SPWWYFAV-ISVSGVFAVTFSVVFAYVADITQEH---ERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAI 82
Cdd:cd17471  85 NYWVLLLVgVVLLSLGAAAFPQLFALAREYADRSsgrDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALL 164

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  83 ALLdicfILVAVPESLPEKMRPAswgapiswEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKF 162
Cdd:cd17471 165 YLV----VALLVLFLLPSVKPPA--------QKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGG 232

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 163 sPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMM 222
Cdd:cd17471 233 -SESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQL 291
MFS_BCD_PucC-like cd06176
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ...
 7-235 8.26e-03

Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 349950 [Multi-domain]  Cd Length: 409  Bit Score: 37.86  E-value: 8.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338   7 SPWWYFAVISVSGVFAVTFSVV----FAYVADITQEHERSMAYGLV-SATFAASLVTSPAIGAYLGRVYGDSL--VVVLA 79
Cdd:cd06176  99 FWLGLALAVLAFLLYGIGVGAAgtafLALLADLTPEERRPRAVTVVwTMLILGIIVTAIVFGRLLDPYSPERLiqVFQIV 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  80 TAIALLDICFILVAVpeslpEKMRPASWGAPISWEQADPFASLKKVGQDSIVLLICITVFLSYLpeagqysSFFL----- 154
Cdd:cd06176 179 ALVALLLALLALWGV-----ERRRSRAALAAEEAPPETFREALRLLWASPQARRFFIFLFLSTL-------ALFMqdvil 246

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 155 --YLRQIMKFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQ---LAWYGFGSEPWM-------- 221
Cdd:cd06176 247 epFGGEVFGMSVGETTRLTAIWGGGTLLGMLLAGFLLSRRLGKKRTAALGCLLSALGfllLALAGLLGNPWLfrpgvfll 326

                       250
                ....*....|....*....
gi 39992338 222 -----MWAAGAVAAMSSIT 235
Cdd:cd06176 327 glgngLFTVGALTLMMDLT 345
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 17-281 8.83e-03

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 37.96  E-value: 8.83e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  17 VSGVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGA------YLGRVYGDSLVVVLATAIALLDICFI 90
Cdd:cd17326 104 LIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAaftpigYPGYVIGIKLRFNMYTAPAWLMAILG 183

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338  91 LVAVpeslpekmrpaswgapisweqadpfaslkkvgqdsIVLLICITVFLSYLPEAGQYSSFFLY------LRQIM---- 160
Cdd:cd17326 184 IINI-----------------------------------ILILFFFKEVVCIFLFFVVLFIFANLetigtpLTMDMygwt 228

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39992338 161 -KFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYgfgsepwMMWAAGAVAAMsSITFPAV 239
Cdd:cd17326 229 rEEAVLYNGIILAVSGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFVVT-------LPWGITGVILF-GLGYPIG 300

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 39992338 240 S----ALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 281
Cdd:cd17326 301 NvmlyTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHF 346
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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