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Conserved domains on  [gi|49116153|gb|AAH73146|]
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ANKMY1 protein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4642 super family cl34799
Uncharacterized conserved protein [Function unknown];
80-156 1.68e-18

Uncharacterized conserved protein [Function unknown];


The actual alignment was detected with superfamily member COG4642:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 86.16  E-value: 1.68e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 49116153  80 QGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMKT 156
Cdd:COG4642 185 QGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYAD 261
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
374-543 1.13e-15

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.07  E-value: 1.13e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49116153 374 RMALSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAalp 452
Cdd:COG0666  88 NTLLHAAARNGDLEIVKLLLEAGADVNARDKDgETPLHLAAYNGNLEIVKLLLEAGADVNAQDN---DGNTPLHLAA--- 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49116153 453 gEEG-VQIVELLLHAITDVDAKASDeddtykpgkldllpsslklsnepgppqayystdtalpeegGRTALHMACEREDDN 531
Cdd:COG0666 162 -ANGnLEIVKLLLEAGADVNARDND----------------------------------------GETPLHLAAENGHLE 200

                       170
                ....*....|..
gi 49116153 532 KIDRLISHGADI 543
Cdd:COG0666 201 IVKLLLEAGADV 212
zf-MYND pfam01753
MYND finger;
659-699 4.19e-09

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 52.42  E-value: 4.19e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 49116153   659 CYQCGRSiGVRLLPCPRCYGILTCSKYCKTKAWtEFHKKDC 699
Cdd:pfam01753   1 CAVCGKE-ALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
162-189 1.63e-03

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.09  E-value: 1.63e-03
                        10        20
                ....*....|....*....|....*...
gi 49116153 162 HCHNDIVNLLLDCGADVNKCSDEGLTAL 189
Cdd:COG0666 130 NGNLEIVKLLLEAGADVNAQDNDGNTPL 157
DUF2857 super family cl12747
Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.
 336-410 7.83e-03

Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.


The actual alignment was detected with superfamily member pfam11198:

Pssm-ID: 431719  Cd Length: 174  Bit Score: 38.02  E-value: 7.83e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 49116153   336 FSIELSQAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLccvpMQVLF 410
Cdd:pfam11198  25 FSPEELDALKSLSLEDLHYLSNARVSFLRVTVDHDVLRRLLAQAREEQERRQLIDRALRLGASIEL----MARLF 95
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
80-156 1.68e-18

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 86.16  E-value: 1.68e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 49116153  80 QGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMKT 156
Cdd:COG4642 185 QGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYAD 261
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
374-543 1.13e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.07  E-value: 1.13e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49116153 374 RMALSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAalp 452
Cdd:COG0666  88 NTLLHAAARNGDLEIVKLLLEAGADVNARDKDgETPLHLAAYNGNLEIVKLLLEAGADVNAQDN---DGNTPLHLAA--- 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49116153 453 gEEG-VQIVELLLHAITDVDAKASDeddtykpgkldllpsslklsnepgppqayystdtalpeegGRTALHMACEREDDN 531
Cdd:COG0666 162 -ANGnLEIVKLLLEAGADVNARDND----------------------------------------GETPLHLAAENGHLE 200

                       170
                ....*....|..
gi 49116153 532 KIDRLISHGADI 543
Cdd:COG0666 201 IVKLLLEAGADV 212
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 85-150 5.30e-15

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 79.11  E-value: 5.30e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 49116153   85 WQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYG 150
Cdd:PLN03185  28 WSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLG 93
Ank_2 pfam12796
Ankyrin repeats (3 copies);
388-473 2.06e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.12  E-value: 2.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49116153   388 TIKLLLRRGADPNLC-CVPMQVLFLAVKAGDVDGVRLLLEHGARTDicfppQLSTLTPLHIAAalpgEEG-VQIVELLLH 465
Cdd:pfam12796  12 LVKLLLENGADANLQdKNGRTALHLAAKNGHLEIVKLLLEHADVNL-----KDNGRTALHYAA----RSGhLEIVKLLLE 82


                  ....*...
gi 49116153   466 AITDVDAK 473
Cdd:pfam12796  83 KGADINVK 90
zf-MYND pfam01753
MYND finger;
659-699 4.19e-09

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 52.42  E-value: 4.19e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 49116153   659 CYQCGRSiGVRLLPCPRCYGILTCSKYCKTKAWtEFHKKDC 699
Cdd:pfam01753   1 CAVCGKE-ALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 387-543 1.26e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.59  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49116153  387 RTIKLLLRRGADPNLC----CVPMQVLfLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAALPGEEgVQIVEL 462
Cdd:PHA03100  87 EIVKLLLEYGANVNAPdnngITPLLYA-ISKKSNSYSIVEYLLDNGANVNIKNS---DGENLLHLYLESNKID-LKILKL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49116153  463 LLHAITDVDAKasdeddtykpGKLDLLPSslklsnepgppqayYSTDTALPEEGGRTALHMACEREDDNKIDRLISHGAD 542
Cdd:PHA03100 162 LIDKGVDINAK----------NRVNYLLS--------------YGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGAN 217


                 .
gi 49116153  543 I 543
Cdd:PHA03100 218 P 218
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 114-136 3.45e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 38.16  E-value: 3.45e-04
                          10        20
                  ....*....|....*....|...
gi 49116153   114 YHGQFYRDHCHGLGTYMWPDGSS 136
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
113-133 7.69e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 37.32  E-value: 7.69e-04
                           10        20
                   ....*....|....*....|.
gi 49116153    113 SYHGQFYRDHCHGLGTYMWPD 133
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 517-543 8.90e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 8.90e-04
                           10        20
                   ....*....|....*....|....*..
gi 49116153    517 GRTALHMACEREDDNKIDRLISHGADI 543
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADI 28
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
162-189 1.63e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.09  E-value: 1.63e-03
                        10        20
                ....*....|....*....|....*...
gi 49116153 162 HCHNDIVNLLLDCGADVNKCSDEGLTAL 189
Cdd:COG0666 130 NGNLEIVKLLLEAGADVNAQDNDGNTPL 157
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 166-198 2.84e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.80  E-value: 2.84e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 49116153  166 DIVNLLLDCGADVNKCSDEGLTALSMCFLLHYP 198
Cdd:PHA03100 206 EFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
DUF2857 pfam11198
Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.
 336-410 7.83e-03

Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.


Pssm-ID: 431719  Cd Length: 174  Bit Score: 38.02  E-value: 7.83e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 49116153   336 FSIELSQAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLccvpMQVLF 410
Cdd:pfam11198  25 FSPEELDALKSLSLEDLHYLSNARVSFLRVTVDHDVLRRLLAQAREEQERRQLIDRALRLGASIEL----MARLF 95
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
80-156 1.68e-18

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 86.16  E-value: 1.68e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 49116153  80 QGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMKT 156
Cdd:COG4642 185 QGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYAD 261
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
374-543 1.13e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.07  E-value: 1.13e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49116153 374 RMALSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAalp 452
Cdd:COG0666  88 NTLLHAAARNGDLEIVKLLLEAGADVNARDKDgETPLHLAAYNGNLEIVKLLLEAGADVNAQDN---DGNTPLHLAA--- 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49116153 453 gEEG-VQIVELLLHAITDVDAKASDeddtykpgkldllpsslklsnepgppqayystdtalpeegGRTALHMACEREDDN 531
Cdd:COG0666 162 -ANGnLEIVKLLLEAGADVNARDND----------------------------------------GETPLHLAAENGHLE 200

                       170
                ....*....|..
gi 49116153 532 KIDRLISHGADI 543
Cdd:COG0666 201 IVKLLLEAGADV 212
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
80-155 2.92e-15

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 76.53  E-value: 2.92e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 49116153  80 QGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMK 155
Cdd:COG4642 139 GGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYA 214
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
80-153 3.49e-15

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 76.53  E-value: 3.49e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 49116153  80 QGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMY 153
Cdd:COG4642 162 QGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLT 235
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 85-150 5.30e-15

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 79.11  E-value: 5.30e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 49116153   85 WQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYG 150
Cdd:PLN03185  28 WSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLG 93
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
376-545 2.33e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 71.14  E-value: 2.33e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49116153 376 ALSMIERRKRWRTIKLLLRRGADPNLCCVPMQ-VLFLAVKAGDVDGVRLLLEHGARTDIcfpPQLSTLTPLHIAAalpgE 454
Cdd:COG0666 123 PLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNtPLHLAAANGNLEIVKLLLEAGADVNA---RDNDGETPLHLAA----E 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49116153 455 EG-VQIVELLLHAITDVDAKASDeddtykpgkldllpsslklsnepgppqayystdtalpeegGRTALHMACEREDDNKI 533
Cdd:COG0666 196 NGhLEIVKLLLEAGADVNAKDND----------------------------------------GKTALDLAAENGNLEIV 235

                       170
                ....*....|..
gi 49116153 534 DRLISHGADILK 545
Cdd:COG0666 236 KLLLEAGADLNA 247
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
80-141 1.50e-12

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 68.44  E-value: 1.50e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 49116153  80 QGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTF 141
Cdd:COG4642 208 QGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYADGSVYEGEW 269
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
80-153 5.14e-11

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 63.82  E-value: 5.14e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 49116153  80 QGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMY 153
Cdd:COG4642 116 GGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLT 189
Ank_2 pfam12796
Ankyrin repeats (3 copies);
388-473 2.06e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.12  E-value: 2.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49116153   388 TIKLLLRRGADPNLC-CVPMQVLFLAVKAGDVDGVRLLLEHGARTDicfppQLSTLTPLHIAAalpgEEG-VQIVELLLH 465
Cdd:pfam12796  12 LVKLLLENGADANLQdKNGRTALHLAAKNGHLEIVKLLLEHADVNL-----KDNGRTALHYAA----RSGhLEIVKLLLE 82


                  ....*...
gi 49116153   466 AITDVDAK 473
Cdd:pfam12796  83 KGADINVK 90
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 79-161 3.95e-09

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 59.85  E-value: 3.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49116153   79 VQGVQE------WQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTM 152
Cdd:PLN03185 108 IQGLQEgpgkytWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGKGVF 187

                         90
                 ....*....|
gi 49116153  153 YMK-TRLFQT 161
Cdd:PLN03185 188 YPAgSRVPAV 197
zf-MYND pfam01753
MYND finger;
659-699 4.19e-09

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 52.42  E-value: 4.19e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 49116153   659 CYQCGRSiGVRLLPCPRCYGILTCSKYCKTKAWtEFHKKDC 699
Cdd:pfam01753   1 CAVCGKE-ALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
Ank_2 pfam12796
Ankyrin repeats (3 copies);
409-543 2.32e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.04  E-value: 2.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49116153   409 LFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAAlpgEEGVQIVELLL-HAITDVDakasdeddtykpgkld 487
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDK---NGRTALHLAAK---NGHLEIVKLLLeHADVNLK---------------- 58

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 49116153   488 llpsslklsnepgppqayystdtalpeEGGRTALHMACEREDDNKIDRLISHGADI 543
Cdd:pfam12796  59 ---------------------------DNGRTALHYAARSGHLEIVKLLLEKGADI 87
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 387-543 1.26e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.59  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49116153  387 RTIKLLLRRGADPNLC----CVPMQVLfLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAALPGEEgVQIVEL 462
Cdd:PHA03100  87 EIVKLLLEYGANVNAPdnngITPLLYA-ISKKSNSYSIVEYLLDNGANVNIKNS---DGENLLHLYLESNKID-LKILKL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49116153  463 LLHAITDVDAKasdeddtykpGKLDLLPSslklsnepgppqayYSTDTALPEEGGRTALHMACEREDDNKIDRLISHGAD 542
Cdd:PHA03100 162 LIDKGVDINAK----------NRVNYLLS--------------YGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGAN 217


                 .
gi 49116153  543 I 543
Cdd:PHA03100 218 P 218
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
77-155 8.57e-06

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 48.03  E-value: 8.57e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 49116153  77 QLVQGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMK 155
Cdd:COG4642  90 DGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYA 168
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 87-156 1.06e-05

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 49.06  E-value: 1.06e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49116153   87 DGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTmYMKT 156
Cdd:PLN03185   7 NGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGT-YTGT 75
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 80-150 8.63e-05

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 45.98  E-value: 8.63e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 49116153   80 QGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYG 150
Cdd:PLN03185  46 NGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPG 116
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 392-541 9.68e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 45.37  E-value: 9.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49116153  392 LLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAalpgEEG-VQIVELLLHAITD 469
Cdd:PHA02875  21 LLDIGINPNFEIYDgISPIKLAMKFRDSEAIKLLMKHGAIPDVKYP---DIESELHDAV----EEGdVKAVEELLDLGKF 93

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 49116153  470 VDakasdeDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACEREDDNKIDRLISHGA 541
Cdd:PHA02875  94 AD------DVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKA 159
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 376-475 2.06e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.49  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49116153  376 ALSMIERRKRWRTIKLLLRRGADPNlccVPMQV----LFLAVKAGDVDGVRLLLEHGARTDIcfpPQLSTLTPLHIAAAL 451
Cdd:PHA02878 171 ALHYATENKDQRLTELLLSYGANVN---IPDKTnnspLHHAVKHYNKPIVHILLENGASTDA---RDKCGNTPLHISVGY 244

                         90       100
                 ....*....|....*....|....
gi 49116153  452 PgeEGVQIVELLLHAITDVDAKAS 475
Cdd:PHA02878 245 C--KDYDILKLLLEHGVDVNAKSY 266
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 377-471 3.24e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.83  E-value: 3.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49116153  377 LSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDI--CFppqlsTLTPLHIAAAlpg 453
Cdd:PHA02875 106 LHLATILKKLDIMKLLIARGADPDIPNTDkFSPLHLAVMMGDIKGIELLIDHKACLDIedCC-----GCTPLIIAMA--- 177

                         90
                 ....*....|....*...
gi 49116153  454 EEGVQIVELLLHAITDVD 471
Cdd:PHA02875 178 KGDIAICKMLLDSGANID 195
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 114-136 3.45e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 38.16  E-value: 3.45e-04
                          10        20
                  ....*....|....*....|...
gi 49116153   114 YHGQFYRDHCHGLGTYMWPDGSS 136
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
113-133 7.69e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 37.32  E-value: 7.69e-04
                           10        20
                   ....*....|....*....|.
gi 49116153    113 SYHGQFYRDHCHGLGTYMWPD 133
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 517-543 7.86e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 7.86e-04
                          10        20
                  ....*....|....*....|....*...
gi 49116153   517 GRTALHMACEREDDNKI-DRLISHGADI 543
Cdd:pfam00023   2 GNTPLHLAAGRRGNLEIvKLLLSKGADV 29
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 517-543 8.90e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 8.90e-04
                           10        20
                   ....*....|....*....|....*..
gi 49116153    517 GRTALHMACEREDDNKIDRLISHGADI 543
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADI 28
PHA03095 PHA03095
ankyrin-like protein; Provisional
 385-543 9.78e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 42.32  E-value: 9.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49116153  385 RWRTIKLLLRRGADPNLCCV----PMQVlFLAVKAGDVDGVRLLLEHGArtDICfPPQLSTLTPLHIAAALPGEEgVQIV 460
Cdd:PHA03095  96 TLDVIKLLIKAGADVNAKDKvgrtPLHV-YLSGFNINPKVIRLLLRKGA--DVN-ALDLYGMTPLAVLLKSRNAN-VELL 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49116153  461 ELLLHAITDVDAKaSDEDDTYkpgkLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMA-----CEReddNKIDR 535
Cdd:PHA03095 171 RLLIDAGADVYAV-DDRFRSL----LHHHLQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMatgssCKR---SLVLP 242


                 ....*...
gi 49116153  536 LISHGADI 543
Cdd:PHA03095 243 LLIAGISI 250
Ank_4 pfam13637
Ankyrin repeats (many copies);
406-464 1.27e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.25  E-value: 1.27e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 49116153   406 MQVLFLAVKAGDVDGVRLLLEHGA---RTDICFppqlstLTPLHIAAAlpgEEGVQIVELLL 464
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGAdinAVDGNG------ETALHFAAS---NGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
162-189 1.63e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.09  E-value: 1.63e-03
                        10        20
                ....*....|....*....|....*...
gi 49116153 162 HCHNDIVNLLLDCGADVNKCSDEGLTAL 189
Cdd:COG0666 130 NGNLEIVKLLLEAGADVNAQDNDGNTPL 157
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 517-543 2.38e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 2.38e-03
                          10        20
                  ....*....|....*....|....*..
gi 49116153   517 GRTALHMACEREDDNKIDRLISHGADI 543
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADI 28
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 166-198 2.84e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.80  E-value: 2.84e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 49116153  166 DIVNLLLDCGADVNKCSDEGLTALSMCFLLHYP 198
Cdd:PHA03100 206 EFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
162-189 6.53e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 39.17  E-value: 6.53e-03
                        10        20
                ....*....|....*....|....*...
gi 49116153 162 HCHNDIVNLLLDCGADVNKCSDEGLTAL 189
Cdd:COG0666 163 NGNLEIVKLLLEAGADVNARDNDGETPL 190
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 443-473 7.06e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.57  E-value: 7.06e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 49116153   443 TPLHIAAALPGeeGVQIVELLLHAITDVDAK 473
Cdd:pfam00023   4 TPLHLAAGRRG--NLEIVKLLLSKGADVNAR 32
DUF2857 pfam11198
Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.
 336-410 7.83e-03

Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.


Pssm-ID: 431719  Cd Length: 174  Bit Score: 38.02  E-value: 7.83e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 49116153   336 FSIELSQAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLccvpMQVLF 410
Cdd:pfam11198  25 FSPEELDALKSLSLEDLHYLSNARVSFLRVTVDHDVLRRLLAQAREEQERRQLIDRALRLGASIEL----MARLF 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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