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Conserved domains on  [gi|52139021|gb|AAH82573|]
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Rho GTPase activating protein 30 [Mus musculus]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 10138166)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

CATH:  1.10.555.10
Gene Ontology:  GO:0007165|GO:0005096
PubMed:  17222083|12480336
SCOP:  4001255

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 16-210 3.79e-105

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 327.54  E-value: 3.79e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   16 RVFGCDLREHLQHSGQEVPQVLRSCAEFVQEYGVVDGIYRLSGVSSNIQKLRQEFETERKPDLRRDVYLQDIHCVSSLCK 95
Cdd:cd04384    1 RVFGCDLTEHLLNSGQDVPQVLKSCTEFIEKHGIVDGIYRLSGIASNIQRLRHEFDSEQIPDLTKDVYIQDIHSVSSLCK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   96 AYFRELPDPLLTYRLYDKFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAP 175
Cdd:cd04384   81 LYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVWAP 160

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 52139021  176 NLLRSKDIEASGFNGTAAFMEVRVQSIVVEFILTH 210
Cdd:cd04384  161 NLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNH 195
PTZ00121 super family cl31754
MAEBL; Provisional
 622-880 8.49e-04

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 8.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   622 EGVGSLEEEAAGCGKQPPTQDEEEQACSETRQEKEAKprstsdnREEAEATPETEMEAGKADaEGGEAERSQKVmdsfke 701
Cdd:PTZ00121 1596 EVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEK-------KKVEQLKKKEAEEKKKAE-ELKKAEEENKI------ 1661

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   702 gsREELEAKEENSEGREVESIKETKDVEKIIGEPGKDEEREIGREEGAEKGDDTPVDSdmdPEHVFQEDLVLEESWEVVH 781
Cdd:PTZ00121 1662 --KAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKK---AEELKKAEEENKIKAEEAK 1736

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   782 KHEAEKGRESEtkELRRKSDLKSREDQGHSEDSGSPEEGDDRKEGVFSKEQKSIDVE--TEVMRGVGDHLEEGA-LSEGP 858
Cdd:PTZ00121 1737 KEAEEDKKKAE--EAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKrrMEVDKKIKDIFDNFAnIIEGG 1814

                         250       260
                  ....*....|....*....|..
gi 52139021   859 GVELLRVDSTEEIneQTSEMKQ 880
Cdd:PTZ00121 1815 KEGNLVINDSKEM--EDSAIKE 1834
 
Name Accession Description Interval E-value
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 16-210 3.79e-105

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 327.54  E-value: 3.79e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   16 RVFGCDLREHLQHSGQEVPQVLRSCAEFVQEYGVVDGIYRLSGVSSNIQKLRQEFETERKPDLRRDVYLQDIHCVSSLCK 95
Cdd:cd04384    1 RVFGCDLTEHLLNSGQDVPQVLKSCTEFIEKHGIVDGIYRLSGIASNIQRLRHEFDSEQIPDLTKDVYIQDIHSVSSLCK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   96 AYFRELPDPLLTYRLYDKFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAP 175
Cdd:cd04384   81 LYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVWAP 160

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 52139021  176 NLLRSKDIEASGFNGTAAFMEVRVQSIVVEFILTH 210
Cdd:cd04384  161 NLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNH 195
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 31-211 1.36e-55

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 190.56  E-value: 1.36e-55
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021      31 QEVPQVLRSCAEFVQEYGV-VDGIYRLSGVSSNIQKLRQEFEteRKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYR 109
Cdd:smart00324    1 KPIPIIVEKCIEYLEKRGLdTEGIYRVSGSKSRVKELRDAFD--SGPDPDLDLSEYDVHDVAGLLKLFLRELPEPLITYE 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021     110 LYDKFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDieasgfN 189
Cdd:smart00324   79 LYEEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPD------G 152

                           170       180
                    ....*....|....*....|..
gi 52139021     190 GTAAFMEVRVQSIVVEFILTHV 211
Cdd:smart00324  153 EVASLKDIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 34-182 1.28e-52

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 180.82  E-value: 1.28e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021     34 PQVLRSCAEFVQEYGV-VDGIYRLSGVSSNIQKLRQEFETERKPDLrrDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYD 112
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLdTEGIFRVSGSASRIKELREAFDRGPDVDL--DLEEEDVHVVASLLKLFLRELPEPLLTFELYE 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021    113 KFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKD 182
Cdd:pfam00620   79 EFIEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
PTZ00121 PTZ00121
MAEBL; Provisional
 622-880 8.49e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 8.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   622 EGVGSLEEEAAGCGKQPPTQDEEEQACSETRQEKEAKprstsdnREEAEATPETEMEAGKADaEGGEAERSQKVmdsfke 701
Cdd:PTZ00121 1596 EVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEK-------KKVEQLKKKEAEEKKKAE-ELKKAEEENKI------ 1661

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   702 gsREELEAKEENSEGREVESIKETKDVEKIIGEPGKDEEREIGREEGAEKGDDTPVDSdmdPEHVFQEDLVLEESWEVVH 781
Cdd:PTZ00121 1662 --KAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKK---AEELKKAEEENKIKAEEAK 1736

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   782 KHEAEKGRESEtkELRRKSDLKSREDQGHSEDSGSPEEGDDRKEGVFSKEQKSIDVE--TEVMRGVGDHLEEGA-LSEGP 858
Cdd:PTZ00121 1737 KEAEEDKKKAE--EAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKrrMEVDKKIKDIFDNFAnIIEGG 1814

                         250       260
                  ....*....|....*....|..
gi 52139021   859 GVELLRVDSTEEIneQTSEMKQ 880
Cdd:PTZ00121 1815 KEGNLVINDSKEM--EDSAIKE 1834
 
Name Accession Description Interval E-value
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 16-210 3.79e-105

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 327.54  E-value: 3.79e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   16 RVFGCDLREHLQHSGQEVPQVLRSCAEFVQEYGVVDGIYRLSGVSSNIQKLRQEFETERKPDLRRDVYLQDIHCVSSLCK 95
Cdd:cd04384    1 RVFGCDLTEHLLNSGQDVPQVLKSCTEFIEKHGIVDGIYRLSGIASNIQRLRHEFDSEQIPDLTKDVYIQDIHSVSSLCK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   96 AYFRELPDPLLTYRLYDKFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAP 175
Cdd:cd04384   81 LYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVWAP 160

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 52139021  176 NLLRSKDIEASGFNGTAAFMEVRVQSIVVEFILTH 210
Cdd:cd04384  161 NLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNH 195
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 31-211 1.36e-55

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 190.56  E-value: 1.36e-55
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021      31 QEVPQVLRSCAEFVQEYGV-VDGIYRLSGVSSNIQKLRQEFEteRKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYR 109
Cdd:smart00324    1 KPIPIIVEKCIEYLEKRGLdTEGIYRVSGSKSRVKELRDAFD--SGPDPDLDLSEYDVHDVAGLLKLFLRELPEPLITYE 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021     110 LYDKFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDieasgfN 189
Cdd:smart00324   79 LYEEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPD------G 152

                           170       180
                    ....*....|....*....|..
gi 52139021     190 GTAAFMEVRVQSIVVEFILTHV 211
Cdd:smart00324  153 EVASLKDIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 34-182 1.28e-52

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 180.82  E-value: 1.28e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021     34 PQVLRSCAEFVQEYGV-VDGIYRLSGVSSNIQKLRQEFETERKPDLrrDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYD 112
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLdTEGIFRVSGSASRIKELREAFDRGPDVDL--DLEEEDVHVVASLLKLFLRELPEPLLTFELYE 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021    113 KFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKD 182
Cdd:pfam00620   79 EFIEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 34-210 5.23e-50

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 174.41  E-value: 5.23e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   34 PQVLRSCAEFVQEYGV-VDGIYRLSGVSSNIQKLRQEFETERKPDLRRDVylqDIHCVSSLCKAYFRELPDPLLTYRLYD 112
Cdd:cd00159    1 PLIIEKCIEYLEKNGLnTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDY---DVHDVASLLKLYLRELPEPLIPFELYD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021  113 KFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASgfngta 192
Cdd:cd00159   78 EFIELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLRPPDSDDE------ 151

                        170
                 ....*....|....*...
gi 52139021  193 AFMEVRVQSIVVEFILTH 210
Cdd:cd00159  152 LLEDIKKLNEIVEFLIEN 169
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 18-215 1.80e-42

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 153.71  E-value: 1.80e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   18 FGCDLREHLQHSGQEVPQVLRSCAEFVQEYGV-VDGIYRLSGVSSNIQKLRQEFETErkPD----LRRDVYLQDIHCVSS 92
Cdd:cd04398    1 FGVPLEDLILREGDNVPNIVYQCIQAIENFGLnLEGIYRLSGNVSRVNKLKELFDKD--PLnvllISPEDYESDIHSVAS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   93 LCKAYFRELPDPLLTYRLYDKFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIV 172
Cdd:cd04398   79 LLKLFFRELPEPLLTKALSREFIEAAKIEDESRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVNRMSVNNLAII 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 52139021  173 WAPNLLR--SKDIEASGFngtaafmevrvQSIVVEFILTHVDQLF 215
Cdd:cd04398  159 WGPTLMNaaPDNAADMSF-----------QSRVIETLLDNAYQIF 192
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 16-218 2.41e-42

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 153.77  E-value: 2.41e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   16 RVFGCDLREHLQHSGQEVPQVLRSCAEFVQEYGVVD-GIYRLSGVSSNIQKLRQEFETER-KPDLrrDVYLQDIHCVSSL 93
Cdd:cd04386    3 PVFGTPLEEHLKRTGREIALPIEACVMCLLETGMNEeGLFRVGGGASKLKRLKAALDAGTfSLPL--DEFYSDPHAVASA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   94 CKAYFRELPDPLLTYRLYDKFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVW 173
Cdd:cd04386   81 LKSYLRELPDPLLTYNLYEDWVQAANKPDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNIAIVL 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 52139021  174 APNLLRSKdIEASGFNGTAAfMEVRVqSIVVEFILTHVDQLFRGD 218
Cdd:cd04386  161 APNLLWAK-NEGSLAEMAAG-TSVHV-VAIVELIISHADWFFPGE 202
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 18-209 1.56e-39

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 144.84  E-value: 1.56e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   18 FGCDLREHLQHSGQEVPQVLRSCAEFVQEYGV-VDGIYRLSGVSSNIQKLRQEFETERKPDLRrDVYLQDIHCVSSLCKA 96
Cdd:cd04403    1 FGCHLEALCQRENSTVPKFVRLCIEAVEKRGLdVDGIYRVSGNLAVIQKLRFAVDHDEKLDLD-DSKWEDIHVITGALKL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   97 YFRELPDPLLTYRLYDKFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPN 176
Cdd:cd04403   80 FFRELPEPLFPYSLFNDFVAAIKLSDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIVFGPT 159

                        170       180       190
                 ....*....|....*....|....*....|...
gi 52139021  177 LLRSKDiEASGFNGTAAFmevrvQSIVVEFILT 209
Cdd:cd04403  160 LLRPEQ-ETGNIAVHMVY-----QNQIVELILL 186
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 18-215 4.30e-35

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 132.64  E-value: 4.30e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   18 FGCDLREHLQHSGQEVPQVLRSCAEFVQEYGVV-DGIYRLSGVSSNIQKLRQEFETE-RKPDLRRDVYlQDIHCVSSLCK 95
Cdd:cd04372    1 YGCDLTTLVKAHNTQRPMVVDMCIREIEARGLQsEGLYRVSGFAEEIEDVKMAFDRDgEKADISATVY-PDINVITGALK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   96 AYFRELPDPLLTYRLYDKFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAP 175
Cdd:cd04372   80 LYFRDLPIPVITYDTYPKFIDAAKISNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIVFGP 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 52139021  176 NLLRSKDIEASgfngtAAFMEVRVQSIVVEFILTHVDQLF 215
Cdd:cd04372  160 TLMRPPEDSAL-----TTLNDMRYQILIVQLLITNEDVLF 194
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 17-215 1.97e-33

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 127.90  E-value: 1.97e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   17 VFGCDLREHL-QHSGQEVPQVLRSCAEFVQEYGV-VDGIYRLSGVSSNIQKLRQEFETERKPDLRRDVYLQDIHCVSSLC 94
Cdd:cd04395    1 TFGVPLDDCPpSSENPYVPLIVEVCCNIVEARGLeTVGIYRVPGNNAAISALQEELNRGGFDIDLQDPRWRDVNVVSSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   95 KAYFRELPDPLLTYRLYDKFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWA 174
Cdd:cd04395   81 KSFFRKLPEPLFTNELYPDFIEANRIEDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNLAIVFG 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 52139021  175 PNLLRSKDIeasgfNGTAAFMEVRVQSIVVEFILTHVDQLF 215
Cdd:cd04395  161 PTLVRTSDD-----NMETMVTHMPDQCKIVETLIQHYDWFF 196
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 18-215 2.23e-32

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 124.76  E-value: 2.23e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   18 FGCDLrEHLQHSGQE---VPQVLRSCAEFVQEYGV-VDGIYRLSGVSSNIQKLRQefeterKPDLRRDVYLQ---DIHCV 90
Cdd:cd04404    6 FGVSL-QFLKEKNPEqepIPPVVRETVEYLQAHALtTEGIFRRSANTQVVKEVQQ------KYNMGEPVDFDqyeDVHLP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   91 SSLCKAYFRELPDPLLTYRLYDKFAEAVAVQLEpERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLA 170
Cdd:cd04404   79 AVILKTFLRELPEPLLTFDLYDDIVGFLNVDKE-ERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLA 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 52139021  171 IVWAPNLLRSKDIEA--SGFNGTAAFmevrvqsivVEFILTHVDQLF 215
Cdd:cd04404  158 VVFGPNLLWAKDASMslSAINPINTF---------TKFLLDHQDEIF 195
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 24-182 4.88e-31

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 120.49  E-value: 4.88e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   24 EHLQHSGQEVPQVLRSCAEFVQEYGV-VDGIYRLSGVSSNIQKLRQEFET-ERKPDLRRDVYlqDIHCVSSLCKAYFREL 101
Cdd:cd04385    6 EDQQLTDNDIPVIVDKCIDFITQHGLmSEGIYRKNGKNSSVKKLLEAFRKdARSVQLREGEY--TVHDVADVLKRFLRDL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021  102 PDPLLTYRLYDKFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSK 181
Cdd:cd04385   84 PDPLLTSELHAEWIEAAELENKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGPTLFQTD 163


                 .
gi 52139021  182 D 182
Cdd:cd04385  164 E 164
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 18-210 2.99e-30

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 119.06  E-value: 2.99e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   18 FGCDLREHLQHSGQEVPQVLRSCAEFVQEYGV-VDGIYRLSGVSSNIQKLRQEFETERkpDLrrdVYLQDI--HCVSSLC 94
Cdd:cd04378    1 FGVDFSQVPRDFPDEVPFIIKKCTSEIENRALgVQGIYRVSGSKARVEKLCQAFENGK--DL---VELSELspHDISSVL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   95 KAYFRELPDPLLTYRLYDKF-------------AEAVAVQLEPER-LVKILEVLQELPIQNYRTLEFLMRHLVHMASFSA 160
Cdd:cd04378   76 KLFLRQLPEPLILFRLYNDFialakeiqrdteeDKAPNTPIEVNRiIRKLKDLLRQLPASNYNTLQHLIAHLYRVAEQFE 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 52139021  161 QTNMHARNLAIVWAPNLLRSKDIEASgfNGTAAFMEVRVQSIVVEFILTH 210
Cdd:cd04378  156 ENKMSPNNLGIVFGPTLIRPRPGDAD--VSLSSLVDYGYQARLVEFLITN 203
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 33-210 1.19e-29

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 116.95  E-value: 1.19e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   33 VPQVLRSCAEFVQEYGVVD-GIYRLSGVSSNIQKLRQEFETERKpDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLY 111
Cdd:cd04387   16 VPYIVRQCVEEVERRGMEEvGIYRISGVATDIQALKAAFDTNNK-DVSVMLSEMDVNAIAGTLKLYFRELPEPLFTDELY 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021  112 DKFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGT 191
Cdd:cd04387   95 PNFAEGIALSDPVAKESCMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLATVFGPTLLRPSEKESKIPTNT 174

                        170       180
                 ....*....|....*....|..
gi 52139021  192 AAF---MEVRVQSIVVEFILTH 210
Cdd:cd04387  175 MTDswsLEVMSQVQVLLYFLQL 196
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 33-182 1.49e-29

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 116.38  E-value: 1.49e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   33 VPQVLRSCAEFVQEYGV-VDGIYRLSGVSSNIQKLRQEFETErkPDlrrDVYLQD--IHCVSSLCKAYFRELPDPLLTYR 109
Cdd:cd04377   15 VPLVLEKLLEHIEMHGLyTEGIYRKSGSANKIKELRQGLDTD--PD---SVNLEDypIHVITSVLKQWLRELPEPLMTFE 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 52139021  110 LYDKFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKD 182
Cdd:cd04377   90 LYENFLRAMELEEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIVFAPCILRCPD 162
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 35-210 8.06e-28

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 112.10  E-value: 8.06e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   35 QVLRSCAEFVQEYGVVD-GIYRLSGVSSNIQKLRQEFETERKP---DLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRL 110
Cdd:cd04374   30 KFVRKCIEAVETRGINEqGLYRVVGVNSKVQKLLSLGLDPKTStpgDVDLDNSEWEIKTITSALKTYLRNLPEPLMTYEL 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021  111 YDKFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDieasgfNG 190
Cdd:cd04374  110 HNDFINAAKSENLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTLLRPQE------ET 183

                        170       180
                 ....*....|....*....|
gi 52139021  191 TAAFMEVRVQSIVVEFILTH 210
Cdd:cd04374  184 VAAIMDIKFQNIVVEILIEN 203
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 33-182 8.81e-27

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 108.54  E-value: 8.81e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   33 VPQVLRSCAEFVQEYGV-VDGIYRLSGVSSNIQKLRQEFETErkPDlrrDVYLQD--IHCVSSLCKAYFRELPDPLLTYR 109
Cdd:cd04407   15 VPIVLEKLLEHVEMHGLyTEGIYRKSGSANRMKELHQLLQAD--PE---NVKLENypIHAITGLLKQWLRELPEPLMTFA 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 52139021  110 LYDKFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKD 182
Cdd:cd04407   90 QYNDFLRAVELPEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAIVFAPCLLRCPD 162
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 28-177 5.59e-26

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 105.98  E-value: 5.59e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   28 HSGQEVPQVLRSCAEFVQEYGV-VDGIYRLSGVSSNIQKLRQEFETERKPDLrrDVYlqDIHCVSSLCKAYFRELPDPLL 106
Cdd:cd04381   15 HDGIDLPLVFRECIDYVEKHGMkCEGIYKVSGIKSKVDELKAAYNRRESPNL--EEY--EPPTVASLLKQYLRELPEPLL 90

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 52139021  107 TYRLYDKFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNL 177
Cdd:cd04381   91 TKELMPRFEEACGRPTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISIVLSPTV 161
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 17-181 8.20e-26

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 105.99  E-value: 8.20e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   17 VFGCDLREHLQHS---GQE-VPQVLRSCAEFVQEYGVVD-GIYRLSGVSSNIQKLRQEFETERKPDLRRDVylqDIHCVS 91
Cdd:cd04390    2 VFGQRLEDTVAYErkfGPRlVPILVEQCVDFIREHGLKEeGLFRLPGQANLVKQLQDAFDAGERPSFDSDT---DVHTVA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   92 SLCKAYFRELPDPLLTYRLYDKFAEAVAVQL--EPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNL 169
Cdd:cd04390   79 SLLKLYLRELPEPVIPWAQYEDFLSCAQLLSkdEEKGLGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNL 158

                        170
                 ....*....|..
gi 52139021  170 AIVWAPNLLRSK 181
Cdd:cd04390  159 ATVFGPNILRPK 170
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 17-177 1.54e-25

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 104.75  E-value: 1.54e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   17 VFGCDLREHLQHSGQE-----VPQVLRSCAEFVQEYGVV--DGIYRLSGVSSNIQKLRQEFETERKPDLRRDVYLQDIHC 89
Cdd:cd04400    1 IFGSPLEEAVELSSHKyngrdLPSVVYRCIEYLDKNRAIyeEGIFRLSGSASVIKQLKERFNTEYDVDLFSSSLYPDVHT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   90 VSSLCKAYFRELPDPLLTYRLYDKFAEAVAVQLEPERLVKIL-EVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARN 168
Cdd:cd04400   81 VAGLLKLYLRELPTLILGGELHNDFKRLVEENHDRSQRALELkDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNLRN 160


                 ....*....
gi 52139021  169 LAIVWAPNL 177
Cdd:cd04400  161 VCIVFSPTL 169
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 29-207 3.88e-25

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 103.69  E-value: 3.88e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   29 SGQEVPQVLRSCAEFVQEYGV-VDGIYRLSGVSSNIQKLRQEFETERKPDL-RRDVylqDIHCVSSLCKAYFRELPDPLL 106
Cdd:cd04373   11 SEKPIPIFLEKCVEFIEATGLeTEGIYRVSGNKTHLDSLQKQFDQDHNLDLvSKDF---TVNAVAGALKSFFSELPDPLI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021  107 TYRLYDKFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEAS 186
Cdd:cd04373   88 PYSMHLELVEAAKINDREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSICFWPTLMRPDFTSME 167

                        170       180
                 ....*....|....*....|.
gi 52139021  187 GFNGTAAFmevrvQSIVVEFI 207
Cdd:cd04373  168 ALSATRIY-----QTIIETFI 183
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 32-215 1.40e-24

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 102.52  E-value: 1.40e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   32 EVPQVLRSCAEFVQEYGV-VDGIYRLSGVSSNIQKLRQEFeterkpDLRRDVYLQDIHC---VSSLCKAYFRELPDPLLT 107
Cdd:cd04376    8 QVPRLVESCCQHLEKHGLqTVGIFRVGSSKKRVRQLREEF------DRGIDVVLDENHSvhdVAALLKEFFRDMPDPLLP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021  108 YRLYDKFAEAVAVQLEpERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQT-----------NMHARNLAIVWAPN 176
Cdd:cd04376   82 RELYTAFIGTALLEPD-EQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSidedgqevsgnKMTSLNLATIFGPN 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 52139021  177 LLRSKDIEASGFNGTAAFMEVRVQSI-VVEFILTHVDQLF 215
Cdd:cd04376  161 LLHKQKSGEREFVQASLRIEESTAIInVVQTMIDNYEELF 200
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 18-210 1.89e-23

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 99.50  E-value: 1.89e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   18 FGCDLREHLQHSGQEVPQVLRSCAEFVQEYGV-VDGIYRLSGVSSNIQKLRQEFETERkpDLrrdVYLQDI--HCVSSLC 94
Cdd:cd04409    1 FGADFAQVAKKSPDGIPFIIKKCTSEIESRALcLKGIYRVNGAKSRVEKLCQAFENGK--DL---VELSELspHDISNVL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   95 KAYFRELPDPLLTYRLYDKF---------------------AEAVAVQLEPER-LVKILEVLQELPIQNYRTLEFLMRHL 152
Cdd:cd04409   76 KLYLRQLPEPLILFRLYNEFiglakesqhvnetqeakknsdKKWPNMCTELNRiLLKSKDLLRQLPAPNYNTLQFLIVHL 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 52139021  153 VHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASgfNGTAAFMEVRVQSIVVEFILTH 210
Cdd:cd04409  156 HRVSEQAEENKMSASNLGIIFGPTLIRPRPTDAT--VSLSSLVDYPHQARLVELLITY 211
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 18-210 2.41e-23

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 99.12  E-value: 2.41e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   18 FGCDLREHLQHSGQEVPQVLRSCAEFVQEYGV-VDGIYRLSGVSSNIQKLRQEFETERkpDLrrdVYLQDI--HCVSSLC 94
Cdd:cd04408    1 FGVDFSQLPRDFPEEVPFVVVRCTAEIENRALgVQGIYRISGSKARVEKLCQAFENGR--DL---VDLSGHspHDITSVL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   95 KAYFRELPDPLLTYRLYDKF-AEAVAVQLEPERLVK-----------ILEVLQELPIQNYRTLEFLMRHLVHMASFSAQT 162
Cdd:cd04408   76 KHFLKELPEPVLPFQLYDDFiALAKELQRDSEKAAEspsiveniirsLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDN 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 52139021  163 NMHARNLAIVWAPNLLR---SKDIEASgfngtaAFMEVRVQSIVVEFILTH 210
Cdd:cd04408  156 KMSPNNLGIVFGPTLLRplvGGDVSMI------CLLDTGYQAQLVEFLISN 200
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 16-208 1.03e-22

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 96.72  E-value: 1.03e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   16 RVFGCDLREHLQHSGQEVPQVLRSCAEFVQEYGVV-DGIYRLSGVSSNIQKLRQEFETERKPdLRRDVYLQDIHCVSSLC 94
Cdd:cd04383    1 KLFNGSLEEYIQDSGQAIPLVVESCIRFINLYGLQhQGIFRVSGSQVEVNDIKNAFERGEDP-LADDQNDHDINSVAGVL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   95 KAYFRELPDPLLTYRLYDKFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWA 174
Cdd:cd04383   80 KLYFRGLENPLFPKERFEDLMSCVKLENPTERVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFG 159

                        170       180       190
                 ....*....|....*....|....*....|....
gi 52139021  175 PNLLRSKDieasgfNGTAAFMEVRVQSIVVEFIL 208
Cdd:cd04383  160 PTLMPVPE------GQDQVSCQAHVNELIKTIII 187
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 16-177 1.04e-22

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 96.76  E-value: 1.04e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   16 RVFGCDLREhLQHSGQ---EVPQVLRSCAEFVQEYGVV-DGIYRLSGVSSNIQKLRQEFETERKPDLRRDvylQDIHCVS 91
Cdd:cd04393    1 KVFGVPLQE-LQQAGQpenGVPAVVRHIVEYLEQHGLEqEGLFRVNGNAETVEWLRQRLDSGEEVDLSKE---ADVCSAA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   92 SLCKAYFRELPDPLLTYRLYDKFAEAVA-VQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLA 170
Cdd:cd04393   77 SLLRLFLQELPEGLIPASLQIRLMQLYQdYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLA 156


                 ....*..
gi 52139021  171 IVWAPNL 177
Cdd:cd04393  157 AVFGPDV 163
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 17-177 1.99e-22

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 96.72  E-value: 1.99e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   17 VFGCDLREHLQHSGQEVPQVLRSCAEFVQEYgVVD--GIYRLSGVSSNIQKLRQEFETERKPDLRRDvylQDIHCVSSLC 94
Cdd:cd04375    4 VFGVPLLVNLQRTGQPLPRSIQQAMRWLRNN-ALDqvGLFRKSGVKSRIQKLRSMIESSTDNVNYDG---QQAYDVADML 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   95 KAYFRELPDPLLTYRLYDKFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWA 174
Cdd:cd04375   80 KQYFRDLPEPLLTNKLSETFIAIFQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTATNLAVCLA 159


                 ...
gi 52139021  175 PNL 177
Cdd:cd04375  160 PSL 162
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 18-182 1.71e-21

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 93.69  E-value: 1.71e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   18 FGCDLREHLQHSGQ--EVPQVLRSCAEFVQEYGV-VDGIYRLSGVSSNIQKLRQEFETE-RKPDLRRDVYlQDIHCVSSL 93
Cdd:cd04379    1 FGVPLSRLVEREGEsrDVPIVLQKCVQEIERRGLdVIGLYRLCGSAAKKKELRDAFERNsAAVELSEELY-PDINVITGV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   94 CKAYFRELPDPLLTYRLYDKFAEAVAVQLePERLVK----ILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNL 169
Cdd:cd04379   80 LKDYLRELPEPLITPQLYEMVLEALAVAL-PNDVQTnthlTLSIIDCLPLSAKATLLLLLDHLSLVLSNSERNKMTPQNL 158

                        170
                 ....*....|...
gi 52139021  170 AIVWAPNLLRSKD 182
Cdd:cd04379  159 AVCFGPVLMFCSQ 171
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 18-182 7.63e-21

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 91.22  E-value: 7.63e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   18 FGCDLrEHLQHSGQEVPQVLRSCAEFVQEYGV-VDGIYRLSGVSSNIQKLRQEFETERKpDLRRDVYlqDIHCVSSLCKA 96
Cdd:cd04406    1 FGVEL-SRLTSEDRSVPLVVEKLINYIEMHGLyTEGIYRKSGSTNKIKELRQGLDTDAN-SVNLDDY--NIHVIASVFKQ 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   97 YFRELPDPLLTYRLYDKFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMaSFSAQTN-MHARNLAIVWAP 175
Cdd:cd04406   77 WLRDLPNPLMTFELYEEFLRAMGLQERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRI-ALQEETNrMSANALAIVFAP 155


                 ....*..
gi 52139021  176 NLLRSKD 182
Cdd:cd04406  156 CILRCPD 162
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 33-182 1.12e-17

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 82.35  E-value: 1.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   33 VPQVLRSCAEFVQEYG-VVDGIYRLSGVSSNIQKLRQEFETERKPDLRRdvylQDIHCVSSLCKAYFRELPDPLLTYRLY 111
Cdd:cd04402   15 LPKPILDMLSLLYQKGpSTEGIFRRSANAKACKELKEKLNSGVEVDLKA----EPVLLLASVLKDFLRNIPGSLLSSDLY 90

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 52139021  112 DKFAEAVAVQLEPERLVKILEVLQELPIQNYrtleFLMRHLV---HMASFSAQTN-MHARNLAIVWAPNLLRSKD 182
Cdd:cd04402   91 EEWMSALDQENEEEKIAELQRLLDKLPRPNV----LLLKHLIcvlHNISQNSETNkMDAFNLAVCIAPSLLWPPA 161
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 18-179 5.93e-17

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 80.13  E-value: 5.93e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   18 FGCDLREHLQ-----HSGQEVPQVLRSCAEFVQEYGV--VDGIYRLSGVSSNIQKLRQEFETERKPDLRrdvyLQDIHCV 90
Cdd:cd04389    1 FGSSLEEIMDrqkekYPELKLPWILTFLSEKVLALGGfqTEGIFRVPGDIDEVNELKLRVDQWDYPLSG----LEDPHVP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   91 SSLCKAYFRELPDPLLTYRLYDkfaEAVAVQLEPErlvKILEVLQELPIQNYRTLEFLMRHLVHMASFS--AQTNMHARN 168
Cdd:cd04389   77 ASLLKLWLRELEEPLIPDALYQ---QCISASEDPD---KAVEIVQKLPIINRLVLCYLINFLQVFAQPEnvAHTKMDVSN 150

                        170
                 ....*....|.
gi 52139021  169 LAIVWAPNLLR 179
Cdd:cd04389  151 LAMVFAPNILR 161
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 52-208 7.50e-17

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 80.03  E-value: 7.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   52 GIYRLSGVSSNIQKLRQEFETERKPDLRRDVylqDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVAVQLEPERLVKIL 131
Cdd:cd04382   37 GLYRVSGSEREVKALKEKFLRGKTVPNLSKV---DIHVICGCLKDFLRSLKEPLITFALWKEFMEAAEILDEDNSRAALY 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 52139021  132 EVLQELPIQNYRTLEFLMRHLVHMASfSAQTNMHARNLAIVWAPNLLRSKDIEASgfnGTAAFMEVRVQSIVVEFIL 208
Cdd:cd04382  114 QAISELPQPNRDTLAFLILHLQRVAQ-SPECKMDINNLARVFGPTIVGYSVPNPD---PMTILQDTVRQPRVVERLL 186
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 50-214 9.55e-17

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 80.10  E-value: 9.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   50 VDGIYRLSGvssNIQKLRQ-EFETERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVAVQLEPERLV 128
Cdd:cd04397   45 VEGVFRKNG---NIRRLKElTEEIDKNPTEVPDLSKENPVQLAALLKKFLRELPDPLLTFKLYRLWISSQKIEDEEERKR 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021  129 KILEVLQELPIQNYRTLEFLMRHLVHMASFS-----AQTNMHARNLAIVWAPNLLRSKDIEASGFNGTaaFMEVRvqsiV 203
Cdd:cd04397  122 VLHLVYCLLPKYHRDTMEVLFSFLKWVSSFShideeTGSKMDIHNLATVITPNILYSKTDNPNTGDEY--FLAIE----A 195

                        170
                 ....*....|.
gi 52139021  204 VEFILTHVDQL 214
Cdd:cd04397  196 VNYLIENNEEF 206
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 30-215 8.52e-15

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 74.69  E-value: 8.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   30 GQEVPQVLRSCAEFVQEYGV-VDGIYRLSGVSSNIQKLRQEFETerkpDLRRDVYLQD---IHCVSSLCKAYFRELPDPL 105
Cdd:cd04391   19 GSKVPLIFQKLINKLEERGLeTEGILRIPGSAQRVKFLCQELEA----KFYEGTFLWDqvkQHDAASLLKLFIRELPQPL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021  106 LTYRLYDKFAE-----AVAVQLEPERLVKILevlqeLPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS 180
Cdd:cd04391   95 LTVEYLPAFYSvqglpSKKDQLQALNLLVLL-----LPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVAMIMAPNLFPP 169

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 52139021  181 KDIEASGFNGTAAFMEVRVQ-SIVVEFILTHVDQLF 215
Cdd:cd04391  170 RGKHSKDNESLQEEVNMAAGcANIMRLLIRYQDLLW 205
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 17-182 1.19e-13

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 70.96  E-value: 1.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   17 VFGCDLR----EHLQHSGqEVPQVLRSCAEFVQEYGVVDGIYRLSGVSSNIQKLRQEFETerKPDLRRDVYLQDihcVSS 92
Cdd:cd04394    1 VFGVPLHslphSTVPEYG-NVPKFLVDACTFLLDHLSTEGLFRKSGSVVRQKELKAKLEG--GEACLSSALPCD---VAG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   93 LCKAYFRELPDPLLTYRLYDKFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIV 172
Cdd:cd04394   75 LLKQFFRELPEPLLPYDLHEALLKAQELPTDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVI 154

                        170
                 ....*....|
gi 52139021  173 WAPNLLRSKD 182
Cdd:cd04394  155 FAPNLFQSEE 164
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 17-214 7.96e-13

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 68.98  E-value: 7.96e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   17 VFGCDLREHLQHSGQEV---------------PQVLRSCAEFVQEYGV-VDGIYRLSGVSSNIQKLRQEFETerKPDLRR 80
Cdd:cd04396    1 VFGVSLEESLKYASVAIsivdedgeqyvygyiPVVVAKCGVYLKENATeVEGIFRVAGSSKRIRELQLIFST--PPDYGK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   81 DVYLQD--IHCVSSLCKAYFRELPDPLLTYRLYDKFAEavaVQLEPERLVKILE--------------------VLQELP 138
Cdd:cd04396   79 SFDWDGytVHDAASVLRRYLNNLPEPLVPLDLYEEFRN---PLRKRPRILQYMKgrineplntdidqaikeyrdLITRLP 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 52139021  139 IQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGfngtaafMEVRVQSIVVEFILTHVDQL 214
Cdd:cd04396  156 NLNRQLLLYLLDLLAVFARNSDKNLMTASNLAAIFQPGILSHPDHEMDP-------KEYKLSRLVVEFLIEHQDKF 224
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 50-216 5.82e-11

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 63.25  E-value: 5.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   50 VDGIYRLSGVSSNIQKLRQEFETERKPDLRRDVYlqDIHCVSSLCKAYFRELPDPLLTYRLY-------------DKFAE 116
Cdd:cd04392   26 VEGLFRKPGNSARQQELRDLLNSGTDLDLESGGF--HAHDCATVLKGFLGELPEPLLTHAHYpahlqiadlcqfdEKGNK 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021  117 AVAVQlePERLVKILEVL-QELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTAAFM 195
Cdd:cd04392  104 TSAPD--KERLLEALQLLlLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLICPRNLTPEDLHENAQKL 181

                        170       180
                 ....*....|....*....|.
gi 52139021  196 evrvqSIVVEFILTHVDQLFR 216
Cdd:cd04392  182 -----NSIVTFMIKHSQKLFK 197
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 21-179 8.77e-07

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 50.64  E-value: 8.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   21 DLREhlQHSGQEV-PQVLRSCAEFVQEYGVVDGIYRLSGVSSNIQKLRQEFETERKPdlrRDVYLQDIHCVSSLCKAYFR 99
Cdd:cd04388    4 DLTE--QFSPPDVaPPLLIKLVEAIEKKGLESSTLYRTQSSSSLTELRQILDCDAAS---VDLEQFDVAALADALKRYLL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021  100 ELPDPLLTYRLYD---KFAEAVAVQLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPN 176
Cdd:cd04388   79 DLPNPVIPAPVYSemiSRAQEVQSSDEYAQLLRKLIRSPNLPHQYWLTLQYLLKHFFRLCQSSSKNLLSARALAEIFSPL 158


                 ...
gi 52139021  177 LLR 179
Cdd:cd04388  159 LFR 161
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 65-216 2.84e-05

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 46.56  E-value: 2.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   65 KLRQEFETERKPDLRRdVYLQDIH--CVSSLCKAYFRELPDPLLTYRLYDKFAEA-VAVQL-----EPERLVKILEVLQE 136
Cdd:cd04399   55 QLRNLLNKPKKPDKEV-IILKKFEpsTVASVLKLYLLELPDSLIPHDIYDLIRSLySAYPPsqedsDTARIQGLQSTLSQ 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021  137 LPIQNYRTLEFLMRH---LVHMASFSAQTNMHARNLAIVWAPNLLRSKdIEASGfngtaaFMEVRVQSIVVEFILTHVDQ 213
Cdd:cd04399  134 LPKSHIATLDAIITHfyrLIEITKMGESEEEYADKLATSLSREILRPI-IESLL------TIGDKHGYKFFRDLLTHKDQ 206


                 ...
gi 52139021  214 LFR 216
Cdd:cd04399  207 IFS 209
PTZ00121 PTZ00121
MAEBL; Provisional
 622-880 8.49e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 8.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   622 EGVGSLEEEAAGCGKQPPTQDEEEQACSETRQEKEAKprstsdnREEAEATPETEMEAGKADaEGGEAERSQKVmdsfke 701
Cdd:PTZ00121 1596 EVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEK-------KKVEQLKKKEAEEKKKAE-ELKKAEEENKI------ 1661

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   702 gsREELEAKEENSEGREVESIKETKDVEKIIGEPGKDEEREIGREEGAEKGDDTPVDSdmdPEHVFQEDLVLEESWEVVH 781
Cdd:PTZ00121 1662 --KAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKK---AEELKKAEEENKIKAEEAK 1736

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   782 KHEAEKGRESEtkELRRKSDLKSREDQGHSEDSGSPEEGDDRKEGVFSKEQKSIDVE--TEVMRGVGDHLEEGA-LSEGP 858
Cdd:PTZ00121 1737 KEAEEDKKKAE--EAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKrrMEVDKKIKDIFDNFAnIIEGG 1814

                         250       260
                  ....*....|....*....|..
gi 52139021   859 GVELLRVDSTEEIneQTSEMKQ 880
Cdd:PTZ00121 1815 KEGNLVINDSKEM--EDSAIKE 1834
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 86-182 2.84e-03

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 40.40  E-value: 2.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   86 DIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVAVQlePERLVKILEVLqeLPIQNYRTLEFLMRHLVHMASFSAQTNMH 165
Cdd:cd04380  103 SAESVAEALLLFLESLPDPIIPYSLYERLLEAVANN--EEDKRQVIRIS--LPPVHRNVFVYLCSFLRELLSESADRGLD 178

                         90
                 ....*....|....*..
gi 52139021  166 ARNLAIVWAPNLLRSKD 182
Cdd:cd04380  179 ENTLATIFGRVLLRDPP 195
PTZ00121 PTZ00121
MAEBL; Provisional
 629-900 9.72e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 9.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   629 EEAAGCGKQPPTQDEEEQACSETRQEKEAKPRS----TSDNREEAEATPETEMEAGKADAEGGEAERSQKVMDSFKEGSR 704
Cdd:PTZ00121 1421 DEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAeeakKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKAD 1500

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   705 EELEAKEENSEGREVESIKETKDVEKIIGEPGKDEEREIGREEGAEKGDDTPVDSDmdpehvfqedlvLEESWEVVHKHE 784
Cdd:PTZ00121 1501 EAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEE------------LKKAEEKKKAEE 1568

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139021   785 AEKGRESETKELRRKSDLKSREDQGHSEDSGSPEEGDDRK-EGVFSKEQKSIDVE----TEVMRGVGDHLEEGALSEGPG 859
Cdd:PTZ00121 1569 AKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKaEEAKKAEEAKIKAEelkkAEEEKKKVEQLKKKEAEEKKK 1648

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 52139021   860 VELLR-------VDSTEEINEQTSEMKQA-PLQPSEPEGMEAEGQLNPE 900
Cdd:PTZ00121 1649 AEELKkaeeenkIKAAEEAKKAEEDKKKAeEAKKAEEDEKKAAEALKKE 1697
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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